psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C274	R:R:C28	7.28	No	No	0	5	9
2	R:R:C28	R:R:E277	10.64	No	No	0	9	2
3	R:R:N35	S:S:F276	6.04	No	No	0	3	1
4	R:R:N35	S:S:T279	2.92	No	No	0	3	2
5	R:R:F36	R:R:F40	5.36	No	No	0	4	5
6	R:R:F36	S:S:W283	10.02	No	No	0	4	6
7	R:R:L41	R:R:N37	6.87	No	No	0	6	3
8	R:R:N37	R:R:S285	2.98	No	No	0	3	5
9	R:R:K38	S:S:Q272	5.42	No	No	0	4	2
10	R:R:K38	S:S:F276	16.13	No	No	0	4	1
11	R:R:I39	S:S:I261	5.89	No	No	9	5	5
12	R:R:I39	S:S:V280	4.61	No	Yes	9	5	5
13	R:R:F40	R:R:I44	7.54	No	No	0	5	5
14	R:R:T43	S:S:I257	4.56	No	Yes	0	4	6
15	R:R:A289	R:R:I44	4.87	No	No	0	4	5
16	R:R:L91	R:R:Y45	4.69	Yes	Yes	0	8	7
17	R:R:W94	R:R:Y45	8.68	Yes	Yes	2	7	7
18	R:R:A95	R:R:Y45	2.67	No	Yes	0	7	7
19	R:R:A289	R:R:Y45	2.67	No	Yes	0	4	7
20	R:R:F292	R:R:Y45	5.16	Yes	Yes	2	7	7
21	R:R:S46	S:S:I257	6.19	No	Yes	0	5	6
22	R:R:I47	S:S:L253	4.28	No	No	0	4	5
23	R:R:I48	R:R:L91	2.85	No	Yes	0	7	8
24	R:R:F49	R:R:I53	5.02	Yes	No	0	6	5
25	R:R:F49	R:R:P92	7.22	Yes	No	0	6	9
26	R:R:C296	R:R:T51	5.07	No	No	0	7	5
27	R:R:V54	S:S:L216	5.96	No	No	0	4	4
28	R:R:G55	R:R:P299	4.06	No	Yes	0	8	9
29	R:R:N56	R:R:S81	5.96	Yes	No	0	9	9
30	R:R:D84	R:R:N56	6.73	Yes	Yes	0	9	9
31	R:R:L85	R:R:N56	2.75	No	Yes	0	7	9
32	R:R:N56	R:R:P299	11.4	Yes	Yes	0	9	9
33	R:R:L58	S:S:C220	3.17	No	No	0	5	3
34	R:R:L58	S:S:I223	8.56	No	No	0	5	4
35	R:R:S81	R:R:V59	6.46	No	No	0	9	8
36	R:R:P299	R:R:V59	3.53	Yes	No	0	9	8
37	R:R:V59	R:R:Y302	5.05	No	Yes	0	8	9
38	R:R:I60	R:R:S81	4.64	No	No	0	7	9
39	R:R:I60	R:R:V82	3.07	No	No	0	7	5
40	R:R:I60	R:R:L85	4.28	No	No	0	7	7
41	R:R:V62	S:S:I223	3.07	No	No	0	7	4
42	R:R:K67	R:R:M63	8.64	No	Yes	6	6	6
43	R:R:M63	R:R:R70	6.2	Yes	Yes	6	6	6
44	R:R:D74	R:R:M63	8.32	Yes	Yes	6	8	6
45	R:R:M63	R:R:Y302	7.18	Yes	Yes	6	6	9
46	R:R:G64	R:R:Y65	4.35	No	No	0	2	5
47	R:R:Q66	S:S:S224	5.78	No	No	0	4	4
48	R:R:D74	R:R:K67	2.77	Yes	No	6	8	6
49	R:R:D74	R:R:R70	3.57	Yes	Yes	6	8	6
50	R:R:K75	R:R:R70	14.85	No	Yes	0	6	6
51	R:R:D74	R:R:S71	5.89	Yes	No	0	8	7
52	R:R:D133	R:R:M72	6.93	Yes	No	3	8	6
53	R:R:M72	R:R:R148	9.93	No	Yes	3	6	6
54	R:R:K149	R:R:M72	2.88	No	No	0	6	6
55	R:R:R134	R:R:T73	3.88	Yes	No	0	9	7
56	R:R:D74	R:R:Y302	6.9	Yes	Yes	6	8	9
57	R:R:F129	R:R:Y76	8.25	Yes	Yes	3	5	7
58	R:R:I130	R:R:Y76	4.84	No	Yes	0	8	7
59	R:R:D133	R:R:Y76	4.6	Yes	Yes	3	8	7
60	R:R:L151	R:R:Y76	3.52	No	Yes	3	4	7
61	R:R:A152	R:R:Y76	5.34	No	Yes	0	3	7
62	R:R:V156	R:R:Y76	3.79	Yes	Yes	3	5	7
63	R:R:R77	R:R:T240	3.88	No	No	0	8	7
64	R:R:N298	R:R:R77	12.05	Yes	No	6	9	8
65	R:R:R77	R:R:Y302	29.84	No	Yes	6	8	9
66	R:R:H79	R:R:V156	6.92	No	Yes	3	9	5
67	R:R:H79	R:R:Y157	13.07	No	No	3	9	7
68	R:R:H79	R:R:W161	9.52	No	No	3	9	9
69	R:R:D84	R:R:L80	4.07	Yes	No	0	9	9
70	R:R:I126	R:R:L80	5.71	No	No	0	7	9
71	R:R:L244	R:R:L80	2.77	Yes	No	0	7	9
72	R:R:D84	R:R:N119	5.39	Yes	No	0	9	8
73	R:R:C295	R:R:D84	9.34	Yes	Yes	0	9	9
74	R:R:F87	R:R:L91	4.87	Yes	Yes	0	7	8
75	R:R:F87	R:R:W94	5.01	Yes	Yes	2	7	7
76	R:R:F87	R:R:Y116	7.22	Yes	Yes	2	7	6
77	R:R:F87	R:R:N119	12.08	Yes	No	0	7	8
78	R:R:F292	R:R:F87	16.08	Yes	Yes	2	7	7
79	R:R:C295	R:R:F87	2.79	Yes	Yes	0	9	7
80	R:R:L91	R:R:V88	2.98	Yes	No	0	8	6
81	R:R:C295	R:R:V88	3.42	Yes	No	0	9	6
82	R:R:T90	R:R:V112	4.76	No	No	0	6	5
83	R:R:I115	R:R:T90	4.56	No	No	0	5	6
84	R:R:F104	R:R:F93	11.79	No	No	0	7	6
85	R:R:F93	R:R:L108	4.87	No	No	0	6	5
86	R:R:F93	R:R:V112	3.93	No	No	0	6	5
87	R:R:W94	R:R:Y116	5.79	Yes	Yes	2	7	6
88	R:R:E288	R:R:W94	5.45	Yes	Yes	2	5	7
89	R:R:F292	R:R:W94	8.02	Yes	Yes	2	7	7
90	R:R:W94	W:W:?1	17.21	Yes	Yes	2	7	0
91	R:R:F104	R:R:V96	6.55	No	No	0	7	5
92	R:R:D97	R:R:W102	6.7	No	Yes	2	5	9
93	R:R:D97	R:R:R183	5.96	No	Yes	2	5	3
94	R:R:D97	W:W:?1	22.56	No	Yes	2	5	0
95	R:R:A100	R:R:Y103	4	No	No	0	5	3
96	R:R:N101	R:R:Y103	10.47	No	No	0	4	3
97	R:R:N101	R:R:R183	9.64	No	Yes	0	4	3
98	R:R:N101	R:R:Y184	3.49	No	No	0	4	5
99	R:R:F104	R:R:W102	11.02	No	Yes	0	7	9
100	R:R:G105	R:R:W102	2.81	No	Yes	0	8	9
101	R:R:C109	R:R:W102	6.53	No	Yes	2	9	9
102	R:R:V177	R:R:W102	8.58	Yes	Yes	2	4	9
103	R:R:C186	R:R:W102	15.67	No	Yes	2	9	9
104	R:R:W102	W:W:?1	5.16	Yes	Yes	2	9	0
105	R:R:N106	R:R:N176	6.81	No	No	0	3	4
106	R:R:N106	R:R:V177	5.91	No	Yes	0	3	4
107	R:R:C109	R:R:V177	3.42	No	Yes	2	9	4
108	R:R:C109	R:R:C186	7.28	No	No	2	9	9
109	R:R:K110	R:R:N176	5.6	No	No	0	7	4
110	R:R:D171	R:R:H113	6.3	No	Yes	2	4	6
111	R:R:A175	R:R:H113	5.85	No	Yes	0	4	6
112	R:R:C186	R:R:H113	2.95	No	Yes	2	9	6
113	R:R:H113	R:R:R188	9.03	Yes	No	2	6	5
114	R:R:H113	W:W:?1	5.83	Yes	Yes	2	6	0
115	R:R:T168	R:R:V114	9.52	Yes	No	10	6	5
116	R:R:F172	R:R:V114	15.73	No	No	10	4	5
117	R:R:L120	R:R:Y116	8.21	No	Yes	0	7	6
118	R:R:E288	R:R:Y116	7.86	Yes	Yes	2	5	6
119	R:R:F292	R:R:Y116	4.13	Yes	Yes	2	7	6
120	R:R:Y116	W:W:?1	10.63	Yes	Yes	2	6	0
121	R:R:T117	R:R:T168	6.28	No	Yes	0	5	6
122	R:R:D171	R:R:T117	13.01	No	No	0	4	5
123	R:R:T168	R:R:V118	4.76	Yes	No	0	6	5
124	R:R:H294	R:R:N119	5.1	Yes	No	0	9	8
125	R:R:H203	R:R:L120	12.86	Yes	No	0	4	7
126	R:R:L120	R:R:W252	3.42	No	Yes	0	7	9
127	R:R:L167	R:R:Y121	10.55	No	Yes	0	5	7
128	R:R:Q202	R:R:Y121	4.51	No	Yes	0	3	7
129	R:R:H203	R:R:Y121	4.36	Yes	Yes	0	4	7
130	R:R:V206	R:R:Y121	5.05	No	Yes	0	4	7
131	R:R:G207	R:R:Y121	2.9	No	Yes	0	5	7
132	R:R:S122	R:R:W161	6.18	No	No	0	7	9
133	R:R:F248	R:R:S123	6.61	Yes	No	2	9	9
134	R:R:H294	R:R:S123	2.79	Yes	No	2	9	9
135	R:R:V124	R:R:W125	3.68	Yes	Yes	2	7	5
136	R:R:P211	R:R:V124	8.84	No	Yes	2	9	7
137	R:R:F248	R:R:V124	3.93	Yes	Yes	2	9	7
138	R:R:F249	R:R:V124	3.93	No	Yes	0	4	7
139	R:R:A128	R:R:W125	3.89	No	Yes	0	7	5
140	R:R:P211	R:R:W125	22.97	No	Yes	2	9	5
141	R:R:V214	R:R:W125	4.9	No	Yes	0	6	5
142	R:R:I126	R:R:V160	3.07	No	No	0	7	7
143	R:R:L127	R:R:L244	2.77	No	Yes	0	8	7
144	R:R:I245	R:R:L127	2.85	No	No	0	7	8
145	R:R:F248	R:R:L127	8.53	Yes	No	0	9	8
146	R:R:A128	R:R:I215	3.25	No	No	0	7	7
147	R:R:F129	R:R:L151	6.09	Yes	No	3	5	4
148	R:R:F129	R:R:V155	5.24	Yes	No	3	5	2
149	R:R:F129	R:R:V156	6.55	Yes	Yes	3	5	5
150	R:R:F129	R:R:V160	5.24	Yes	No	3	5	7
151	R:R:I130	R:R:T241	4.56	No	No	0	8	7
152	R:R:I215	R:R:S131	9.29	No	No	0	7	9
153	R:R:C218	R:R:S131	3.44	No	No	0	6	9
154	R:R:S131	R:R:Y219	5.09	No	Yes	0	9	8
155	R:R:D133	R:R:R134	3.57	Yes	Yes	3	8	9
156	R:R:D133	R:R:R148	19.06	Yes	Yes	3	8	6
157	R:R:R134	R:R:R148	4.26	Yes	Yes	3	9	6
158	R:R:L238	R:R:R134	3.64	No	Yes	0	5	9
159	R:R:R134	R:R:T241	5.17	Yes	No	0	9	7
160	R:R:V139	R:R:Y135	12.62	Yes	Yes	11	7	8
161	R:R:H140	R:R:Y135	8.71	No	Yes	11	6	8
162	R:R:C218	R:R:Y135	2.69	No	Yes	0	6	8
163	R:R:I221	R:R:Y135	3.63	No	Yes	0	4	8
164	R:R:L136	R:R:P147	6.57	No	No	0	5	4
165	R:R:L136	R:R:R148	3.64	No	Yes	0	5	6
166	R:R:A137	R:R:R148	6.91	No	Yes	0	8	6
167	R:R:A137	R:R:K234	3.21	No	No	0	8	7
168	R:R:I138	R:R:V139	3.07	No	Yes	0	8	7
169	R:R:I138	R:R:K234	2.91	No	No	0	8	7
170	R:R:H140	R:R:V139	8.3	No	Yes	11	6	7
171	R:R:K225	R:R:V139	3.04	No	Yes	0	4	7
172	R:R:H140	R:R:N143	3.83	No	No	0	6	5
173	R:R:N143	R:R:T142	5.85	No	No	0	5	5
174	R:R:P147	R:R:S144	5.34	No	No	0	4	5
175	R:R:Q145	R:R:R146	3.5	No	No	0	5	5
176	R:R:E153	R:R:K149	14.85	No	No	0	7	6
177	R:R:K154	R:R:L150	4.23	No	No	0	3	4
178	R:R:L151	R:R:V155	5.96	No	No	3	4	2
179	R:R:V156	R:R:Y157	5.05	Yes	No	3	5	7
180	R:R:V156	R:R:V160	3.21	Yes	No	3	5	7
181	R:R:W161	R:R:Y157	2.89	No	No	3	9	7
182	R:R:G159	R:R:P163	4.06	No	No	0	3	4
183	R:R:I162	R:R:P163	5.08	No	No	0	4	4
184	R:R:F172	R:R:T168	3.89	No	Yes	10	4	6
185	R:R:I169	R:R:P170	3.39	No	No	0	3	8
186	R:R:F199	R:R:P170	7.22	Yes	No	0	5	8
187	R:R:D171	R:R:R188	10.72	No	No	2	4	5
188	R:R:F174	R:R:I173	11.3	Yes	No	0	4	3
189	R:R:F174	R:R:Y190	12.38	Yes	Yes	2	4	4
190	R:R:F174	R:R:P191	2.89	Yes	No	2	4	5
191	R:R:F174	R:R:W195	5.01	Yes	Yes	2	4	5
192	R:R:V177	R:R:Y184	3.79	Yes	No	0	4	5
193	R:R:I185	R:R:S178	3.1	No	No	0	3	1
194	R:R:F189	R:R:S178	6.61	No	No	0	3	1
195	R:R:E179	R:R:Y184	20.2	No	No	0	2	5
196	R:R:A180	R:R:D181	3.09	No	No	0	1	2
197	R:R:A180	R:R:I185	3.25	No	No	0	1	3
198	R:R:D182	S:S:Q272	15.66	No	No	0	6	2
199	R:R:I185	R:R:R183	3.76	No	Yes	0	3	3
200	R:R:R183	W:W:?1	4.59	Yes	Yes	2	3	0
201	R:R:D187	R:R:F189	10.75	No	No	0	3	3
202	R:R:D187	W:W:?1	3.08	No	Yes	0	3	0
203	R:R:R188	R:R:Y190	14.4	No	Yes	2	5	4
204	R:R:W195	R:R:Y190	4.82	Yes	Yes	2	5	4
205	R:R:V196	R:R:Y190	3.79	No	Yes	0	4	4
206	R:R:F199	R:R:Y190	11.35	Yes	Yes	2	5	4
207	R:R:P191	R:R:W195	22.97	No	Yes	2	5	5
208	R:R:L194	R:R:N192	5.49	No	No	0	2	1
209	R:R:N192	R:R:W195	5.65	No	Yes	0	1	5
210	R:R:D193	R:R:L266	4.07	No	Yes	0	1	3
211	R:R:F199	R:R:W195	3.01	Yes	Yes	2	5	5
212	R:R:Q200	R:R:V196	2.87	Yes	No	0	5	4
213	R:R:F201	R:R:V197	5.24	No	No	0	4	3
214	R:R:L266	R:R:V197	4.47	Yes	No	0	3	3
215	R:R:F199	R:R:Q202	5.86	Yes	No	0	5	3
216	R:R:I259	R:R:Q200	9.61	Yes	Yes	0	5	5
217	R:R:D262	R:R:Q200	9.14	No	Yes	0	5	5
218	R:R:Q200	R:R:S263	7.22	Yes	No	0	5	5
219	R:R:F201	R:R:S263	6.61	No	No	0	4	5
220	R:R:H203	R:R:Y255	7.62	Yes	Yes	2	4	7
221	R:R:H203	R:R:Y256	13.07	Yes	Yes	2	4	8
222	R:R:I204	R:R:I209	2.94	Yes	No	0	5	4
223	R:R:I204	R:R:Y256	4.84	Yes	Yes	0	5	8
224	R:R:I204	R:R:I259	2.94	Yes	Yes	0	5	5
225	R:R:I204	R:R:S260	3.1	Yes	No	0	5	5
226	R:R:I209	R:R:M205	5.83	No	No	0	4	4
227	R:R:L210	R:R:M205	7.07	No	No	0	6	4
228	R:R:L208	R:R:L253	2.77	No	No	0	8	5
229	R:R:L208	R:R:Y256	10.55	No	Yes	0	8	8
230	R:R:I215	R:R:I245	4.42	No	No	0	7	7
231	R:R:T241	R:R:Y219	3.75	No	Yes	0	7	8
232	R:R:V242	R:R:Y219	3.79	No	Yes	0	4	8
233	R:R:I245	R:R:Y219	3.63	No	Yes	0	7	8
234	R:R:I222	R:R:L238	2.85	No	No	0	8	5
235	R:R:L226	R:R:R235	8.5	Yes	No	0	8	5
236	R:R:K236	R:R:Q233	8.14	No	No	0	8	5
237	R:R:L305	R:R:T240	7.37	No	No	0	6	7
238	R:R:I243	R:R:L301	4.28	No	No	0	5	7
239	R:R:L244	R:R:N298	2.75	Yes	Yes	0	7	9
240	R:R:L244	R:R:L301	2.77	Yes	No	0	7	7
241	R:R:A247	R:R:L297	4.73	No	No	0	6	6
242	R:R:F248	R:R:W252	10.02	Yes	Yes	2	9	9
243	R:R:F248	R:R:H294	9.05	Yes	Yes	2	9	9
244	R:R:W252	R:R:Y255	7.72	Yes	Yes	2	9	7
245	R:R:W252	R:R:Y256	6.75	Yes	Yes	2	9	8
246	R:R:A291	R:R:W252	9.08	No	Yes	0	8	9
247	R:R:F292	R:R:W252	4.01	Yes	Yes	2	7	9
248	R:R:H294	R:R:W252	12.7	Yes	Yes	2	9	9
249	R:R:P254	R:R:T287	3.5	No	No	0	9	6
250	R:R:Y255	R:R:Y256	2.98	Yes	Yes	2	7	8
251	R:R:I259	R:R:Y255	10.88	Yes	Yes	0	5	7
252	R:R:T287	R:R:Y255	3.75	No	Yes	0	6	7
253	R:R:E288	R:R:Y255	13.47	Yes	Yes	2	5	7
254	R:R:G258	R:R:W283	2.81	No	No	0	4	6
255	R:R:G258	R:R:I284	3.53	No	No	0	4	4
256	R:R:I259	R:R:I284	4.42	Yes	No	0	5	4
257	R:R:I261	R:R:I270	4.42	No	Yes	0	5	5
258	R:R:I261	R:R:V280	6.14	No	No	0	5	5
259	R:R:D262	R:R:L266	2.71	No	Yes	0	5	3
260	R:R:D262	R:R:I284	4.2	No	No	0	5	4
261	R:R:I265	R:R:L266	2.85	No	Yes	0	3	3
262	R:R:I265	R:R:I270	5.89	No	Yes	0	3	5
263	R:R:I270	R:R:Q272	2.74	Yes	Yes	0	5	2
264	R:R:K271	R:R:Q272	5.42	No	Yes	0	3	2
265	R:R:F276	R:R:Q272	10.54	No	Yes	0	1	2
266	R:R:F276	R:R:V280	7.87	No	No	0	1	5
267	R:R:K282	R:R:N278	2.8	No	No	0	2	3
268	R:R:T287	R:R:W283	13.34	No	No	0	6	6
269	R:R:I286	R:R:L290	2.85	No	No	0	6	7
270	R:R:E288	R:R:F292	7	Yes	Yes	2	5	7
271	R:R:E288	W:W:?1	17.02	Yes	Yes	2	5	0
272	R:R:C296	R:R:F293	5.59	No	No	0	7	5
273	R:R:C295	R:R:H294	5.9	Yes	Yes	0	9	9
274	R:R:N298	R:R:P299	3.26	Yes	Yes	0	9	9
275	R:R:N298	R:R:Y302	5.81	Yes	Yes	6	9	9
276	R:R:F304	R:R:I300	3.77	No	No	0	6	6
277	S:S:C274	S:S:C28	7.28	No	No	0	5	9
278	S:S:F36	S:S:N37	3.62	No	Yes	0	5	5
279	S:S:F36	S:S:F40	10.72	No	Yes	0	5	4
280	S:S:L41	S:S:N37	4.12	No	Yes	1	5	5
281	S:S:K282	S:S:N37	5.6	No	Yes	0	2	5
282	S:S:N37	S:S:S285	2.98	Yes	No	1	5	5
283	S:S:I286	S:S:N37	4.25	Yes	Yes	1	6	5
284	S:S:F40	S:S:I44	11.3	Yes	No	0	4	4
285	S:S:F40	S:S:I286	6.28	Yes	Yes	1	4	6
286	S:S:F40	S:S:L290	3.65	Yes	No	1	4	7
287	S:S:L41	S:S:Y45	8.21	No	Yes	1	5	7
288	S:S:L41	S:S:S285	3	No	No	1	5	5
289	S:S:P42	S:S:V99	5.3	No	No	0	7	9
290	S:S:L91	S:S:Y45	4.69	Yes	Yes	1	7	7
291	S:S:W94	S:S:Y45	8.68	Yes	Yes	1	5	7
292	S:S:A95	S:S:Y45	2.67	No	Yes	0	5	7
293	S:S:A289	S:S:Y45	4	No	Yes	0	4	7
294	S:S:F292	S:S:Y45	4.13	Yes	Yes	1	7	7
295	S:S:I48	S:S:L91	2.85	No	Yes	0	5	7
296	S:S:F49	S:S:L50	3.65	No	No	0	8	5
297	S:S:F49	S:S:P92	8.67	No	No	0	8	7
298	S:S:C296	S:S:T51	5.07	No	No	0	7	4
299	S:S:G52	S:S:V88	5.52	No	Yes	0	8	8
300	S:S:G55	S:S:P299	4.06	No	Yes	0	5	9
301	S:S:N56	S:S:S81	5.96	Yes	Yes	0	8	9
302	S:S:D84	S:S:N56	4.04	Yes	Yes	0	7	8
303	S:S:L85	S:S:N56	2.75	No	Yes	0	6	8
304	S:S:N56	S:S:P299	6.52	Yes	Yes	0	8	9
305	S:S:M63	S:S:V59	3.04	Yes	Yes	5	4	7
306	S:S:S81	S:S:V59	8.08	Yes	Yes	5	9	7
307	S:S:N298	S:S:V59	2.96	Yes	Yes	5	9	7
308	S:S:P299	S:S:V59	3.53	Yes	Yes	5	9	7
309	S:S:I60	S:S:S81	3.1	Yes	Yes	0	6	9
310	S:S:I60	S:S:V82	3.07	Yes	No	0	6	7
311	S:S:I60	S:S:L85	5.71	Yes	No	0	6	6
312	S:S:K67	S:S:M63	8.64	No	Yes	0	6	4
313	S:S:M63	S:S:R70	4.96	Yes	No	5	4	7
314	S:S:D74	S:S:M63	2.77	No	Yes	5	8	4
315	S:S:L78	S:S:M63	5.65	No	Yes	5	9	4
316	S:S:M63	S:S:Y302	4.79	Yes	Yes	5	4	9
317	S:S:G64	S:S:Y65	4.35	No	No	0	6	6
318	S:S:K75	S:S:R70	8.66	No	No	0	5	7
319	S:S:L78	S:S:R70	8.5	No	No	5	9	7
320	S:S:S71	S:S:T73	3.2	No	Yes	0	8	7
321	S:S:D74	S:S:S71	5.89	No	No	0	8	8
322	S:S:D133	S:S:M72	9.7	Yes	No	4	5	6
323	S:S:M72	S:S:R148	8.69	No	Yes	4	6	6
324	S:S:A152	S:S:M72	3.22	No	No	0	3	6
325	S:S:I130	S:S:T73	4.56	Yes	Yes	4	8	7
326	S:S:R134	S:S:T73	5.17	No	Yes	0	8	7
327	S:S:T241	S:S:T73	3.14	No	Yes	4	7	7
328	S:S:D74	S:S:Y302	5.75	No	Yes	5	8	9
329	S:S:F129	S:S:Y76	10.32	Yes	Yes	4	6	9
330	S:S:I130	S:S:Y76	6.04	Yes	Yes	4	8	9
331	S:S:D133	S:S:Y76	8.05	Yes	Yes	4	5	9
332	S:S:L151	S:S:Y76	3.52	Yes	Yes	4	4	9
333	S:S:A152	S:S:Y76	5.34	No	Yes	0	3	9
334	S:S:V156	S:S:Y76	3.79	No	Yes	4	5	9
335	S:S:L244	S:S:R77	3.64	No	Yes	0	7	9
336	S:S:N298	S:S:R77	12.05	Yes	Yes	5	9	9
337	S:S:L301	S:S:R77	6.07	No	Yes	0	7	9
338	S:S:R77	S:S:Y302	30.87	Yes	Yes	5	9	9
339	S:S:H79	S:S:V156	6.92	No	No	4	5	5
340	S:S:H79	S:S:Y157	7.62	No	No	4	5	7
341	S:S:H79	S:S:W161	6.35	No	No	0	5	9
342	S:S:D84	S:S:L80	2.71	Yes	No	0	7	8
343	S:S:I126	S:S:L80	7.14	No	No	0	5	8
344	S:S:L80	S:S:N298	5.49	No	Yes	0	8	9
345	S:S:N298	S:S:S81	2.98	Yes	Yes	5	9	9
346	S:S:A83	S:S:S122	3.42	No	No	0	7	5
347	S:S:D84	S:S:N119	6.73	Yes	No	1	7	7
348	S:S:D84	S:S:H294	7.56	Yes	Yes	1	7	9
349	S:S:C295	S:S:D84	9.34	Yes	Yes	1	9	7
350	S:S:I115	S:S:L86	2.85	No	No	0	5	4
351	S:S:F87	S:S:T90	3.89	Yes	No	0	6	6
352	S:S:F87	S:S:L91	6.09	Yes	Yes	1	6	7
353	S:S:F87	S:S:W94	5.01	Yes	Yes	1	6	5
354	S:S:F87	S:S:Y116	8.25	Yes	Yes	1	6	8
355	S:S:F87	S:S:N119	8.46	Yes	No	1	6	7
356	S:S:F292	S:S:F87	13.93	Yes	Yes	1	7	6
357	S:S:C295	S:S:F87	2.79	Yes	Yes	1	9	6
358	S:S:L91	S:S:V88	2.98	Yes	Yes	0	7	8
359	S:S:C295	S:S:V88	3.42	Yes	Yes	0	9	8
360	S:S:T90	S:S:V112	3.17	No	No	0	6	5
361	S:S:I115	S:S:T90	6.08	No	No	0	5	6
362	S:S:L91	S:S:W94	4.56	Yes	Yes	1	7	5
363	S:S:F104	S:S:F93	17.15	No	No	0	1	5
364	S:S:F93	S:S:L108	4.87	No	No	0	5	4
365	S:S:F93	S:S:V112	5.24	No	No	0	5	5
366	S:S:W94	S:S:Y116	9.65	Yes	Yes	1	5	8
367	S:S:E288	S:S:W94	6.54	Yes	Yes	1	5	5
368	S:S:F292	S:S:W94	7.02	Yes	Yes	1	7	5
369	K:K:?1	S:S:W94	12.05	Yes	Yes	1	0	5
370	S:S:F104	S:S:V96	6.55	No	No	0	1	4
371	S:S:D97	S:S:W102	4.47	No	Yes	1	5	8
372	S:S:D97	S:S:R183	7.15	No	Yes	1	5	3
373	K:K:?1	S:S:D97	20.51	Yes	No	1	0	5
374	S:S:A100	S:S:Y103	4	No	No	0	3	3
375	S:S:N101	S:S:Y103	8.14	No	No	0	7	3
376	S:S:N101	S:S:R183	8.44	No	Yes	0	7	3
377	S:S:N101	S:S:Y184	11.63	No	No	0	7	5
378	S:S:F104	S:S:W102	12.03	No	Yes	0	1	8
379	S:S:C109	S:S:W102	3.92	Yes	Yes	1	5	8
380	S:S:V177	S:S:W102	4.9	Yes	Yes	1	4	8
381	S:S:C186	S:S:W102	19.59	No	Yes	1	9	8
382	S:S:K110	S:S:N106	2.8	No	No	1	6	9
383	S:S:N106	S:S:N176	8.17	No	No	1	9	4
384	S:S:N106	S:S:V177	7.39	No	Yes	1	9	4
385	S:S:C109	S:S:H113	2.95	Yes	Yes	1	5	6
386	S:S:C109	S:S:V177	3.42	Yes	Yes	1	5	4
387	S:S:C109	S:S:C186	7.28	Yes	No	1	5	9
388	S:S:K110	S:S:N176	5.6	No	No	1	6	4
389	S:S:A175	S:S:H113	7.32	No	Yes	0	4	6
390	S:S:C186	S:S:H113	2.95	No	Yes	1	9	6
391	S:S:H113	S:S:R188	7.9	Yes	Yes	0	6	5
392	S:S:T168	S:S:V114	9.52	Yes	No	7	6	5
393	S:S:F172	S:S:V114	11.8	No	No	7	4	5
394	S:S:L120	S:S:Y116	15.24	No	Yes	1	9	8
395	S:S:W252	S:S:Y116	3.86	Yes	Yes	1	9	8
396	S:S:E288	S:S:Y116	7.86	Yes	Yes	1	5	8
397	S:S:F292	S:S:Y116	7.22	Yes	Yes	1	7	8
398	K:K:?1	S:S:Y116	4.43	Yes	Yes	1	0	8
399	S:S:T117	S:S:T168	7.85	No	Yes	7	7	6
400	S:S:D171	S:S:T117	13.01	No	No	7	4	7
401	S:S:L165	S:S:V118	2.98	No	No	0	3	7
402	S:S:T168	S:S:V118	3.17	Yes	No	0	6	7
403	S:S:H294	S:S:N119	3.83	Yes	No	1	9	7
404	S:S:L120	S:S:W252	4.56	No	Yes	1	9	9
405	S:S:L167	S:S:Y121	10.55	No	Yes	0	5	7
406	S:S:V206	S:S:Y121	3.79	No	Yes	0	4	7
407	S:S:G207	S:S:Y121	2.9	No	Yes	0	5	7
408	S:S:I126	S:S:S122	3.1	No	No	0	5	5
409	S:S:S122	S:S:W161	4.94	No	No	0	5	9
410	S:S:F248	S:S:S123	5.28	Yes	No	0	9	7
411	S:S:P211	S:S:V124	7.07	No	No	0	9	8
412	S:S:F248	S:S:V124	3.93	Yes	No	0	9	8
413	S:S:L210	S:S:W125	6.83	No	No	0	6	7
414	S:S:P211	S:S:W125	21.62	No	No	0	9	7
415	S:S:I126	S:S:I130	2.94	No	Yes	0	5	8
416	S:S:L127	S:S:L244	2.77	No	No	0	8	7
417	S:S:I245	S:S:L127	4.28	No	No	0	7	8
418	S:S:F248	S:S:L127	8.53	Yes	No	0	9	8
419	S:S:A128	S:S:I215	3.25	No	Yes	0	9	7
420	S:S:F129	S:S:L151	6.09	Yes	Yes	4	6	4
421	S:S:F129	S:S:V155	3.93	Yes	No	4	6	2
422	S:S:F129	S:S:V160	3.93	Yes	No	0	6	7
423	S:S:I130	S:S:T241	6.08	Yes	No	4	8	7
424	S:S:I215	S:S:S131	6.19	Yes	No	0	7	9
425	S:S:S131	S:S:Y219	5.09	No	Yes	0	9	8
426	S:S:L132	S:S:L151	2.77	No	Yes	0	8	4
427	S:S:C218	S:S:L132	4.76	No	No	0	6	8
428	S:S:D133	S:S:R148	20.25	Yes	Yes	4	5	6
429	S:S:D133	S:S:L151	2.71	Yes	Yes	4	5	4
430	S:S:L238	S:S:R134	6.07	No	No	0	5	8
431	S:S:L136	S:S:Y135	4.69	No	Yes	0	7	8
432	S:S:V139	S:S:Y135	11.36	No	Yes	12	5	8
433	S:S:H140	S:S:Y135	10.89	No	Yes	12	5	8
434	S:S:C218	S:S:Y135	2.69	No	Yes	0	6	8
435	S:S:I221	S:S:Y135	9.67	No	Yes	0	4	8
436	S:S:L136	S:S:R148	3.64	No	Yes	0	7	6
437	S:S:A137	S:S:R148	5.53	No	Yes	0	6	6
438	S:S:I138	S:S:K234	5.82	No	No	0	8	7
439	S:S:I138	S:S:L238	5.71	No	No	0	8	5
440	S:S:H140	S:S:V139	11.07	No	No	12	5	5
441	S:S:K225	S:S:V139	12.14	No	No	0	4	5
442	S:S:R146	S:S:R148	3.2	No	Yes	0	5	6
443	S:S:E153	S:S:K149	12.15	No	No	0	7	6
444	S:S:L150	S:S:V155	2.98	No	No	0	4	2
445	S:S:L151	S:S:V155	4.47	Yes	No	4	4	2
446	S:S:V156	S:S:Y157	5.05	No	No	4	5	7
447	S:S:G159	S:S:P163	4.06	No	No	0	3	4
448	S:S:I162	S:S:P163	3.39	No	No	0	4	4
449	S:S:I162	S:S:L166	2.85	No	No	0	4	4
450	S:S:L167	S:S:Q202	5.32	No	No	0	5	3
451	S:S:D171	S:S:T168	4.34	No	Yes	7	4	6
452	S:S:F172	S:S:T168	3.89	No	Yes	7	4	6
453	S:S:F199	S:S:P170	13	Yes	No	0	5	8
454	S:S:D171	S:S:R188	5.96	No	Yes	0	4	5
455	S:S:F174	S:S:I173	7.54	Yes	No	0	4	3
456	S:S:F174	S:S:Y190	15.47	Yes	Yes	8	4	4
457	S:S:F174	S:S:P191	5.78	Yes	No	8	4	5
458	S:S:F174	S:S:W195	6.01	Yes	Yes	8	4	5
459	S:S:F174	S:S:F199	3.22	Yes	Yes	8	4	5
460	S:S:V177	S:S:Y184	3.79	Yes	No	0	4	5
461	S:S:F189	S:S:S178	7.93	No	No	0	3	1
462	S:S:I185	S:S:R183	5.01	No	Yes	1	3	3
463	K:K:?1	S:S:R183	9.18	Yes	Yes	1	0	3
464	K:K:?1	S:S:I185	3.24	Yes	No	1	0	3
465	S:S:D187	S:S:F189	9.55	No	No	0	3	3
466	K:K:?1	S:S:D187	3.08	Yes	No	0	0	3
467	S:S:R188	S:S:Y190	12.35	Yes	Yes	0	5	4
468	K:K:?1	S:S:R188	3.67	Yes	Yes	0	0	5
469	S:S:W195	S:S:Y190	2.89	Yes	Yes	8	5	4
470	S:S:V196	S:S:Y190	5.05	No	Yes	0	4	4
471	S:S:F199	S:S:Y190	6.19	Yes	Yes	8	5	4
472	S:S:P191	S:S:W195	9.46	No	Yes	8	5	5
473	S:S:D193	S:S:N192	2.69	No	No	0	1	1
474	S:S:L194	S:S:N192	9.61	No	No	0	2	1
475	S:S:F199	S:S:W195	4.01	Yes	Yes	8	5	5
476	S:S:F199	S:S:V198	3.93	Yes	No	0	5	3
477	S:S:H203	S:S:I204	3.98	No	No	0	4	5
478	S:S:I204	S:S:I209	2.94	No	No	0	5	4
479	S:S:I209	S:S:M205	7.29	No	No	0	4	4
480	S:S:L208	S:S:Y256	19.93	No	No	0	8	8
481	S:S:F249	S:S:I215	3.77	No	Yes	0	4	7
482	S:S:T241	S:S:Y219	3.75	No	Yes	0	7	8
483	S:S:V242	S:S:Y219	7.57	No	Yes	0	4	8
484	S:S:I245	S:S:Y219	3.63	No	Yes	0	7	8
485	S:S:I221	S:S:K225	4.36	No	No	0	4	4
486	S:S:I222	S:S:L238	2.85	No	No	0	8	5
487	S:S:G231	S:S:H232	3.18	No	No	0	4	4
488	S:S:L246	S:S:V242	2.98	No	No	0	5	4
489	S:S:A247	S:S:L297	4.73	No	No	0	6	6
490	S:S:F248	S:S:W252	6.01	Yes	Yes	1	9	9
491	S:S:F248	S:S:H294	9.05	Yes	Yes	1	9	9
492	S:S:C251	S:S:F293	2.79	No	No	1	8	5
493	S:S:C251	S:S:H294	2.95	No	Yes	1	8	9
494	S:S:C251	S:S:L297	3.17	No	No	1	8	6
495	S:S:W252	S:S:Y255	5.79	Yes	Yes	0	9	7
496	S:S:A291	S:S:W252	9.08	No	Yes	0	8	9
497	S:S:F292	S:S:W252	4.01	Yes	Yes	1	7	9
498	S:S:H294	S:S:W252	12.7	Yes	Yes	1	9	9
499	S:S:L253	S:S:P254	3.28	No	No	0	5	9
500	S:S:P254	S:S:T287	3.5	No	No	0	9	6
501	S:S:I259	S:S:Y255	7.25	No	Yes	0	5	7
502	S:S:T287	S:S:Y255	4.99	No	Yes	0	6	7
503	S:S:E288	S:S:Y255	13.47	Yes	Yes	0	5	7
504	S:S:I257	S:S:I261	2.94	Yes	No	0	6	5
505	S:S:G258	S:S:I284	3.53	No	No	0	4	4
506	S:S:I259	S:S:S260	4.64	No	No	0	5	5
507	S:S:I259	S:S:S263	6.19	No	No	0	5	5
508	S:S:I261	S:S:V280	4.61	No	Yes	9	5	5
509	S:S:D262	S:S:I265	9.8	No	No	0	5	3
510	S:S:D262	S:S:V280	7.3	No	Yes	0	5	5
511	S:S:F264	S:S:S263	5.28	No	No	0	4	5
512	S:S:E277	S:S:I265	5.47	No	No	0	2	3
513	S:S:F276	S:S:V280	7.87	No	Yes	0	1	5
514	S:S:I286	S:S:W283	3.52	Yes	No	0	6	6
515	S:S:I286	S:S:L290	2.85	Yes	No	1	6	7
516	S:S:E288	S:S:F292	5.83	Yes	Yes	1	5	7
517	K:K:?1	S:S:E288	13.02	Yes	Yes	1	0	5
518	S:S:F293	S:S:L297	3.65	No	No	1	5	6
519	S:S:C295	S:S:H294	7.37	Yes	Yes	1	9	9
520	S:S:N298	S:S:P299	3.26	Yes	Yes	5	9	9
521	S:S:N298	S:S:Y302	6.98	Yes	Yes	5	9	9
522	R:R:H228	R:R:K225	2.62	No	No	0	5	4
523	R:R:F40	R:R:I286	2.51	No	No	0	5	6
524	R:R:F264	R:R:I270	2.51	No	Yes	0	4	5
525	S:S:T117	S:S:Y121	2.5	No	Yes	0	7	7
526	S:S:F201	S:S:M205	2.49	No	No	0	4	4
527	S:S:K149	S:S:R146	2.48	No	No	0	6	5
528	R:R:F49	R:R:L50	2.44	Yes	No	0	6	5
529	R:R:F49	R:R:L91	2.44	Yes	Yes	0	6	8
530	R:R:F107	R:R:L108	2.44	No	No	0	1	5
531	S:S:F249	S:S:L208	2.44	No	No	0	4	8
532	R:R:L78	R:R:R70	2.43	No	Yes	0	5	6
533	S:S:I284	S:S:Y255	2.42	No	Yes	0	4	7
534	R:R:L41	R:R:Y45	2.34	No	Yes	0	6	7
535	R:R:L61	R:R:Y65	2.34	No	No	0	4	5
536	R:R:C296	R:R:G52	1.96	No	No	0	7	8
537	S:S:C296	S:S:G52	1.96	No	No	0	7	8
538	R:R:A95	R:R:P42	1.87	No	No	0	7	5
539	R:R:A98	R:R:P42	1.87	No	No	0	5	5
540	S:S:A95	S:S:P42	1.87	No	No	0	5	7
541	R:R:G52	R:R:V88	1.84	No	No	0	8	6
542	R:R:G55	R:R:V54	1.84	No	No	0	8	4
543	R:R:G159	R:R:V158	1.84	No	No	0	3	4
544	S:S:G55	S:S:V54	1.84	No	No	0	5	3
545	R:R:P42	R:R:V99	1.77	No	No	0	5	4
546	S:S:G57	S:S:I60	1.76	No	Yes	0	7	6
547	S:S:G212	S:S:I215	1.76	No	Yes	0	6	7
548	S:S:G258	S:S:I257	1.76	No	Yes	0	4	6
549	R:R:G64	R:R:M63	1.75	No	Yes	0	2	6
550	S:S:G64	S:S:M63	1.75	No	Yes	0	6	4
551	R:R:G57	R:R:L85	1.71	No	No	0	3	7
552	R:R:A83	R:R:S122	1.71	No	No	0	8	7
553	R:R:A164	R:R:S122	1.71	No	No	0	7	7
554	S:S:A128	S:S:V214	1.7	No	No	0	9	6
555	S:S:I169	S:S:P170	1.69	No	No	0	3	8
556	R:R:A141	R:R:T142	1.68	No	No	0	8	5
557	R:R:G273	R:R:Q272	1.64	No	Yes	0	5	2
558	S:S:L91	S:S:P92	1.64	Yes	No	0	7	7
559	S:S:G273	S:S:Q272	1.64	No	No	0	5	2
560	R:R:V62	S:S:S224	1.62	No	No	0	7	4
561	S:S:A180	S:S:I185	1.62	No	No	0	1	3
562	S:S:A98	S:S:K38	1.61	No	No	0	4	6
563	R:R:V155	R:R:V158	1.6	No	No	0	2	4
564	R:R:L61	S:S:C220	1.59	No	No	0	4	3
565	R:R:C218	R:R:L132	1.59	No	No	0	6	6
566	R:R:C251	R:R:L297	1.59	No	No	0	8	6
567	S:S:A34	S:S:N37	1.56	No	Yes	0	3	5
568	R:R:I213	R:R:S217	1.55	No	No	0	3	3
569	S:S:I213	S:S:S217	1.55	No	No	0	3	3
570	S:S:I53	S:S:V54	1.54	No	No	0	9	3
571	S:S:I53	S:S:V88	1.54	No	Yes	0	9	8
572	R:R:I89	R:R:T90	1.52	No	No	0	4	6
573	S:S:I47	S:S:T43	1.52	No	No	0	5	5
574	S:S:I47	S:S:T51	1.52	No	No	0	5	4
575	S:S:C274	S:S:E277	1.52	No	No	0	5	2
576	R:R:F249	R:R:G212	1.51	No	No	0	4	6
577	R:R:L86	R:R:V82	1.49	No	No	0	7	5
578	R:R:L165	R:R:V118	1.49	No	No	0	3	5
579	S:S:L58	S:S:V54	1.49	No	No	0	4	3
580	S:S:L58	S:S:V62	1.49	No	No	0	4	5
581	R:R:I209	R:R:I213	1.47	No	No	0	4	3
582	R:R:C251	R:R:H294	1.47	No	Yes	0	8	9
583	R:R:I257	R:R:I261	1.47	No	No	0	6	5
584	S:S:I209	S:S:I213	1.47	No	No	0	4	3
585	S:S:L301	S:S:T240	1.47	No	No	0	7	7
586	R:R:I286	R:R:K282	1.45	No	No	0	6	2
587	S:S:I243	S:S:K239	1.45	No	No	0	5	6
588	R:R:P147	R:R:R146	1.44	No	No	0	4	5
589	S:S:P147	S:S:R146	1.44	No	No	0	4	5
590	R:R:I138	R:R:L226	1.43	No	Yes	0	8	8
591	R:R:I162	R:R:L166	1.43	No	No	0	4	4
592	R:R:I169	R:R:L166	1.43	No	No	0	3	4
593	R:R:I222	R:R:L226	1.43	No	Yes	0	8	8
594	R:R:I223	R:R:L226	1.43	No	Yes	0	4	8
595	S:S:Q66	S:S:V62	1.43	No	No	0	6	5
596	S:S:I89	S:S:L85	1.43	No	No	0	9	6
597	S:S:I138	S:S:L226	1.43	No	No	0	8	8
598	S:S:I162	S:S:L165	1.43	No	No	0	4	3
599	S:S:Q200	S:S:V196	1.43	No	No	0	5	4
600	S:S:I222	S:S:L226	1.43	No	No	0	8	8
601	S:S:I243	S:S:L301	1.43	No	No	0	5	7
602	S:S:I265	S:S:L266	1.43	No	No	0	3	3
603	S:S:G105	S:S:W102	1.41	No	Yes	0	5	8
604	S:S:K154	S:S:L150	1.41	No	No	0	3	4
605	S:S:L210	S:S:M205	1.41	No	No	0	6	4
606	S:S:K38	S:S:N37	1.4	No	Yes	0	6	5
607	S:S:A111	S:S:F107	1.39	No	No	0	5	7
608	R:R:A237	R:R:R134	1.38	No	Yes	0	7	9
609	S:S:K236	S:S:Q233	1.36	No	No	0	8	5
610	R:R:E153	R:R:K154	1.35	No	No	0	7	3
611	S:S:A164	S:S:Y121	1.33	No	Yes	0	7	7
612	S:S:H281	S:S:I284	1.33	No	No	0	4	4
613	R:R:F264	R:R:I269	1.26	No	No	0	4	1
614	S:S:F36	S:S:I39	1.26	No	No	0	5	5
615	S:S:H232	S:S:Q233	1.24	No	No	0	4	5
616	R:R:F304	R:R:L305	1.22	No	No	0	6	6
617	S:S:F107	S:S:L108	1.22	No	No	0	7	4
618	S:S:N192	S:S:W195	1.13	No	Yes	0	1	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y45	4.36833	6	2	7
2	R:R:F49	4.28	4	0	6
3	R:R:N56	6.71	4	0	9
4	R:R:M63	6.418	5	6	6
5	R:R:R70	6.7625	4	6	6
6	R:R:D74	5.49	5	6	8
7	R:R:Y76	5.05667	6	3	7
8	R:R:D84	6.3825	4	0	9
9	R:R:F87	8.00833	6	2	7
10	R:R:L91	3.566	5	0	8
11	R:R:W94	8.36	6	2	7
12	R:R:W102	8.06714	7	2	9
13	R:R:H113	5.992	5	2	6
14	R:R:Y116	7.30667	6	2	6
15	R:R:Y121	5.474	5	0	7
16	R:R:V124	5.095	4	2	7
17	R:R:W125	8.86	4	2	5
18	R:R:F129	6.274	5	3	5
19	R:R:D133	8.54	4	3	8
20	R:R:R134	3.65	6	3	9
21	R:R:Y135	6.9125	4	11	8
22	R:R:V139	6.7575	4	11	7
23	R:R:R148	8.76	5	3	6
24	R:R:V156	5.104	5	3	5
25	R:R:T168	6.1125	4	10	6
26	R:R:F174	7.895	4	2	4
27	R:R:V177	5.425	4	2	4
28	R:R:R183	5.9875	4	2	3
29	R:R:Y190	9.348	5	2	4
30	R:R:W195	8.292	5	2	5
31	R:R:F199	6.86	4	2	5
32	R:R:Q200	7.21	4	0	5
33	R:R:H203	9.4775	4	2	4
34	R:R:I204	3.455	4	0	5
35	R:R:Y219	4.065	4	0	8
36	R:R:L226	3.1975	4	0	8
37	R:R:L244	2.765	4	0	7
38	R:R:F248	7.628	5	2	9
39	R:R:W252	7.67143	7	2	9
40	R:R:Y255	7.73667	6	2	7
41	R:R:Y256	7.638	5	2	8
42	R:R:I259	6.9625	4	0	5
43	R:R:L266	3.525	4	0	3
44	R:R:I270	3.89	4	0	5
45	R:R:Q272	5.085	4	0	2
46	R:R:E288	10.16	5	2	5
47	R:R:F292	7.4	6	2	7
48	R:R:H294	6.16833	6	2	9
49	R:R:C295	5.3625	4	0	9
50	R:R:N298	5.9675	4	6	9
51	R:R:P299	5.5625	4	0	9
52	R:R:Y302	10.956	5	6	9
53	S:S:N37	3.36143	7	1	5
54	S:S:F40	7.9875	4	1	4
55	S:S:Y45	5.39667	6	1	7
56	S:S:N56	4.8175	4	0	8
57	S:S:V59	4.4025	4	5	7
58	S:S:I60	3.41	4	0	6
59	S:S:M63	4.51429	7	5	4
60	S:S:T73	4.0175	4	4	7
61	S:S:Y76	6.17667	6	4	9
62	S:S:R77	13.1575	4	5	9
63	S:S:S81	5.03	4	5	9
64	S:S:D84	6.076	5	1	7
65	S:S:F87	6.91714	7	1	6
66	S:S:V88	3.365	4	0	8
67	S:S:L91	3.80167	6	1	7
68	S:S:W94	7.64429	7	1	5
69	S:S:W102	7.72	6	1	8
70	S:S:C109	4.3925	4	1	5
71	S:S:H113	5.28	4	1	6
72	S:S:Y116	8.07286	7	1	8
73	S:S:Y121	4.214	5	0	7
74	S:S:F129	6.0675	4	4	6
75	S:S:I130	4.905	4	4	8
76	S:S:D133	10.1775	4	4	5
77	S:S:Y135	7.86	5	12	8
78	S:S:R148	8.262	5	4	6
79	S:S:L151	3.912	5	4	4
80	S:S:T168	5.754	5	7	6
81	S:S:F174	7.604	5	8	4
82	S:S:V177	4.875	4	1	4
83	S:S:R183	7.445	4	1	3
84	S:S:R188	7.47	4	0	5
85	S:S:Y190	8.39	5	8	4
86	S:S:W195	4.7	5	8	5
87	S:S:F199	6.07	5	8	5
88	S:S:I215	3.7425	4	0	7
89	S:S:Y219	5.01	4	0	8
90	S:S:F248	6.56	5	1	9
91	S:S:W252	6.57286	7	1	9
92	S:S:Y255	6.784	5	0	7
93	S:S:I257	3.8625	4	0	6
94	S:S:V280	6.0975	4	9	5
95	S:S:I286	4.225	4	1	6
96	S:S:E288	9.344	5	1	5
97	S:S:F292	7.02333	6	1	7
98	S:S:H294	7.24333	6	1	9
99	S:S:C295	5.73	4	1	9
100	S:S:N298	5.62	6	5	9
101	S:S:P299	4.3425	4	5	9
102	S:S:Y302	12.0975	4	5	9
103	W:W:?1	10.76	8	2	0
104	K:K:?1	8.6475	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F36	S:S:W283	99.1143	10.02	No	No	0	4	6
2	S:S:I286	S:S:W283	99.1716	3.52	Yes	No	0	6	6
3	S:S:I286	S:S:N37	99.2174	4.25	Yes	Yes	1	6	5
4	S:S:L41	S:S:N37	99.8017	4.12	No	Yes	1	5	5
5	S:S:L41	S:S:Y45	100	8.21	No	Yes	1	5	7
6	S:S:W94	S:S:Y45	28.2952	8.68	Yes	Yes	1	5	7
7	S:S:F292	S:S:Y45	40.5569	4.13	Yes	Yes	1	7	7
8	S:S:F292	S:S:W252	17.8603	4.01	Yes	Yes	1	7	9
9	R:R:F36	R:R:F40	99.0566	5.36	No	No	0	4	5
10	R:R:A289	R:R:Y45	98.6472	2.67	No	Yes	0	4	7
11	R:R:A289	R:R:I44	98.7066	4.87	No	No	0	4	5
12	R:R:F40	R:R:I44	98.7658	7.54	No	No	0	5	5
13	R:R:L91	R:R:Y45	20.3576	4.69	Yes	Yes	0	8	7
14	R:R:W94	R:R:Y45	30.2096	8.68	Yes	Yes	2	7	7
15	R:R:F292	R:R:Y45	48.0874	5.16	Yes	Yes	2	7	7
16	R:R:F87	R:R:L91	13.1223	4.87	Yes	Yes	0	7	8
17	R:R:F87	R:R:N119	20.5627	12.08	Yes	No	0	7	8
18	R:R:D84	R:R:N119	20.3941	5.39	Yes	No	0	9	8
19	R:R:D84	R:R:N56	19.791	6.73	Yes	Yes	0	9	9
20	R:R:F87	R:R:W94	14.5123	5.01	Yes	Yes	2	7	7
21	R:R:F292	R:R:F87	12.5337	16.08	Yes	Yes	2	7	7
22	R:R:C295	R:R:F87	20.6485	2.79	Yes	Yes	0	9	7
23	R:R:C295	R:R:D84	26.5997	9.34	Yes	Yes	0	9	9
24	R:R:F248	R:R:L127	18.2954	8.53	Yes	No	0	9	8
25	R:R:F248	R:R:W252	19.733	10.02	Yes	Yes	2	9	9
26	R:R:F292	R:R:W252	28.9648	4.01	Yes	Yes	2	7	9
27	R:R:I245	R:R:L127	12.4515	2.85	No	No	0	7	8
28	R:R:I126	R:R:V160	23.7489	3.07	No	No	0	7	7
29	R:R:I126	R:R:L80	24.861	5.71	No	No	0	7	9
30	R:R:D84	R:R:L80	26.4988	4.07	Yes	No	0	9	9
31	R:R:V156	R:R:V160	14.7034	3.21	Yes	No	3	5	7
32	R:R:W94	W:W:?1	11.7196	17.21	Yes	Yes	2	7	0
33	R:R:E288	R:R:Y255	15.7892	13.47	Yes	Yes	2	5	7
34	R:R:I259	R:R:Y255	18.6731	10.88	Yes	Yes	0	5	7
35	R:R:D262	R:R:L266	13.756	2.71	No	Yes	0	5	3
36	R:R:I265	R:R:L266	10.8152	2.85	No	Yes	0	3	3
37	S:S:H294	S:S:W252	11.1802	12.7	Yes	Yes	1	9	9
38	S:S:L91	S:S:V88	11.6161	2.98	Yes	Yes	0	7	8
39	S:S:D84	S:S:H294	10.7812	7.56	Yes	Yes	1	7	9
40	S:S:D84	S:S:N56	21.3605	4.04	Yes	Yes	0	7	8
41	S:S:D84	S:S:L80	57.7307	2.71	Yes	No	0	7	8
42	S:S:L80	S:S:N298	15.1805	5.49	No	Yes	0	8	9
43	S:S:M63	S:S:V59	17.2609	3.04	Yes	Yes	5	4	7
44	S:S:I126	S:S:L80	42.0774	7.14	No	No	0	5	8
45	S:S:I126	S:S:I130	37.3326	2.94	No	Yes	0	5	8
46	S:S:I130	S:S:Y76	29.6104	6.04	Yes	Yes	4	8	9
47	S:S:D133	S:S:Y76	12.0151	8.05	Yes	Yes	4	5	9
48	S:S:D133	S:S:R148	10.4208	20.25	Yes	Yes	4	5	6
49	S:S:F292	S:S:F87	19.8208	13.93	Yes	Yes	1	7	6
50	S:S:F87	S:S:W94	21.3015	5.01	Yes	Yes	1	6	5
51	S:S:L91	S:S:Y45	31.4534	4.69	Yes	Yes	1	7	7
52	S:S:F87	S:S:L91	19.8901	6.09	Yes	Yes	1	6	7
53	S:S:F87	S:S:N119	30.1227	8.46	Yes	No	1	6	7
54	S:S:D84	S:S:N119	29.7801	6.73	Yes	No	1	7	7
55	S:S:C295	S:S:F87	30.1426	2.79	Yes	Yes	1	9	6
56	S:S:C295	S:S:D84	39.2544	9.34	Yes	Yes	1	9	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:L91	S:S:Y45	4.69	1	Yes	Yes	7	7	2	2
S:S:W94	S:S:Y45	8.68	1	Yes	Yes	5	7	1	2
S:S:F292	S:S:Y45	4.13	1	Yes	Yes	7	7	2	2
S:S:F87	S:S:L91	6.09	1	Yes	Yes	6	7	2	2
S:S:F87	S:S:W94	5.01	1	Yes	Yes	6	5	2	1
S:S:F87	S:S:Y116	8.25	1	Yes	Yes	6	8	2	1
S:S:F292	S:S:F87	13.93	1	Yes	Yes	7	6	2	2
S:S:L91	S:S:W94	4.56	1	Yes	Yes	7	5	2	1
S:S:W94	S:S:Y116	9.65	1	Yes	Yes	5	8	1	1
S:S:E288	S:S:W94	6.54	1	Yes	Yes	5	5	1	1
S:S:F292	S:S:W94	7.02	1	Yes	Yes	7	5	2	1
K:K:?1	S:S:W94	12.05	1	Yes	Yes	0	5	0	1
S:S:D97	S:S:W102	4.47	1	No	Yes	5	8	1	2
S:S:D97	S:S:R183	7.15	1	No	Yes	5	3	1	1
K:K:?1	S:S:D97	20.51	1	Yes	No	0	5	0	1
S:S:N101	S:S:R183	8.44	0	No	Yes	7	3	2	1
S:S:H113	S:S:R188	7.9	1	Yes	Yes	6	5	2	1
S:S:L120	S:S:Y116	15.24	1	No	Yes	9	8	2	1
S:S:W252	S:S:Y116	3.86	1	Yes	Yes	9	8	2	1
S:S:E288	S:S:Y116	7.86	1	Yes	Yes	5	8	1	1
S:S:F292	S:S:Y116	7.22	1	Yes	Yes	7	8	2	1
K:K:?1	S:S:Y116	4.43	1	Yes	Yes	0	8	0	1
S:S:L120	S:S:W252	4.56	1	No	Yes	9	9	2	2
S:S:D171	S:S:R188	5.96	7	No	Yes	4	5	2	1
S:S:I185	S:S:R183	5.01	1	No	Yes	3	3	1	1
K:K:?1	S:S:R183	9.18	1	Yes	Yes	0	3	0	1
K:K:?1	S:S:I185	3.24	1	Yes	No	0	3	0	1
S:S:D187	S:S:F189	9.55	0	No	No	3	3	1	2
K:K:?1	S:S:D187	3.08	1	Yes	No	0	3	0	1
S:S:R188	S:S:Y190	12.35	0	Yes	Yes	5	4	1	2
K:K:?1	S:S:R188	3.67	1	Yes	Yes	0	5	0	1
S:S:W252	S:S:Y255	5.79	1	Yes	Yes	9	7	2	2
S:S:F292	S:S:W252	4.01	1	Yes	Yes	7	9	2	2
S:S:E288	S:S:Y255	13.47	1	Yes	Yes	5	7	1	2
S:S:E288	S:S:F292	5.83	1	Yes	Yes	5	7	1	2
K:K:?1	S:S:E288	13.02	1	Yes	Yes	0	5	0	1
S:S:A180	S:S:I185	1.62	0	No	No	1	3	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:W94	R:R:Y45	8.68	2	Yes	Yes	7	7	1	2
R:R:F292	R:R:Y45	5.16	2	Yes	Yes	7	7	2	2
R:R:F87	R:R:W94	5.01	2	Yes	Yes	7	7	2	1
R:R:F87	R:R:Y116	7.22	2	Yes	Yes	7	6	2	1
R:R:F292	R:R:F87	16.08	2	Yes	Yes	7	7	2	2
R:R:W94	R:R:Y116	5.79	2	Yes	Yes	7	6	1	1
R:R:E288	R:R:W94	5.45	2	Yes	Yes	5	7	1	1
R:R:F292	R:R:W94	8.02	2	Yes	Yes	7	7	2	1
R:R:W94	W:W:?1	17.21	2	Yes	Yes	7	0	1	0
R:R:D97	R:R:W102	6.7	2	No	Yes	5	9	1	1
R:R:D97	R:R:R183	5.96	2	No	Yes	5	3	1	1
R:R:D97	W:W:?1	22.56	2	No	Yes	5	0	1	0
R:R:N101	R:R:R183	9.64	0	No	Yes	4	3	2	1
R:R:F104	R:R:W102	11.02	0	No	Yes	7	9	2	1
R:R:G105	R:R:W102	2.81	0	No	Yes	8	9	2	1
R:R:C109	R:R:W102	6.53	2	No	Yes	9	9	2	1
R:R:V177	R:R:W102	8.58	2	Yes	Yes	4	9	2	1
R:R:C186	R:R:W102	15.67	2	No	Yes	9	9	2	1
R:R:W102	W:W:?1	5.16	2	Yes	Yes	9	0	1	0
R:R:C109	R:R:V177	3.42	2	No	Yes	9	4	2	2
R:R:C109	R:R:C186	7.28	2	No	No	9	9	2	2
R:R:D171	R:R:H113	6.3	2	No	Yes	4	6	2	1
R:R:A175	R:R:H113	5.85	0	No	Yes	4	6	2	1
R:R:C186	R:R:H113	2.95	2	No	Yes	9	6	2	1
R:R:H113	R:R:R188	9.03	2	Yes	No	6	5	1	2
R:R:H113	W:W:?1	5.83	2	Yes	Yes	6	0	1	0
R:R:L120	R:R:Y116	8.21	0	No	Yes	7	6	2	1
R:R:E288	R:R:Y116	7.86	2	Yes	Yes	5	6	1	1
R:R:F292	R:R:Y116	4.13	2	Yes	Yes	7	6	2	1
R:R:Y116	W:W:?1	10.63	2	Yes	Yes	6	0	1	0
R:R:D171	R:R:R188	10.72	2	No	No	4	5	2	2
R:R:I185	R:R:R183	3.76	0	No	Yes	3	3	2	1
R:R:R183	W:W:?1	4.59	2	Yes	Yes	3	0	1	0
R:R:D187	R:R:F189	10.75	0	No	No	3	3	1	2
R:R:D187	W:W:?1	3.08	0	No	Yes	3	0	1	0
R:R:E288	R:R:Y255	13.47	2	Yes	Yes	5	7	1	2
R:R:E288	R:R:F292	7	2	Yes	Yes	5	7	1	2
R:R:E288	W:W:?1	17.02	2	Yes	Yes	5	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	3OE8_poly
Class	A
SubFamily	Protein
Type	Chemokine
SubType	CXCR4
Species	Homo sapiens
Ligand	-
Other Ligand(s)	IT1t
Protein Partners	-
PDB Resolution	3.1
Date	2010-10-27
D.O.I.	10.1126/science.1194396

Net Summary
I_min	2.67
Number of Linked Nodes	493
Number of Links	618
Number of Hubs	104
Number of Links mediated by Hubs	374
Number of Communities	12
Number of Nodes involved in Communities	131
Number of Links involved in Communities	202

Path Summary
Number Of Nodes in MetaPath	57
Number Of Links MetaPath	56
Number of Shortest Paths	954697
Length Of Smallest Path	3
Average Path Length	23.2055
Length of Longest Path	41
Minimum Path Strength	1.3
Average Path Strength	5.94238
Maximum Path Strength	18.51
Minimum Path Correlation	0.7
Average Path Correlation	0.966888
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.94118
Average % Of Corr. Nodes	42.5974
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	54.785
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ITD
PDB Residues	W:W:?1 K:K:?1
Environment Details	Open EMBL-EBI Page
Code	ITD
Name	(6,6-dimethyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-3-yl)methyl N,N'-dicyclohexylimidothiocarbamate
Synonyms
Identifier	(6,6-dimethyl-5H-imidazo[2,1-b][1,3]thiazol-3-yl)methyl N,N'-dicyclohexylcarbamimidothioate
Formula	C21 H34 N4 S2
Molecular Weight	406.651
SMILES	CC1(CN2C(=CSC2=N1)CS/C(=N\C3CCCCC3)/NC4CCCCC4)C
PubChem	25147749
Formal Charge	0
Total Atoms	61
Total Chiral Atoms	0
Total Bonds	64
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P61073
Sequence	>3OE8_poly_Chain_R P C N F N K I F L P T I Y S I I F L T G I V G N G L V I L V M G Y Q K K L R S M T D K Y R L H L S V A D L L F V I T L P F W A V D A V A N W Y F G N F L C K A V H V I Y T V N L Y S S V W I L A F I S L D R Y L A I V H A T N S Q R P R K L L A E K V V Y V G V W I P A L L L T I P D F I F A N V S E A D D R Y I C D R F Y P N D L W V V V F Q F Q H I M V G L I L P G I V I L S C Y C I I I S K L S H S H Q K R K A L K T T V I L I L A F F A C W L P Y Y I G I S I D S F I L L E I I K Q G C E F E N T V H K W I S I T E A L A F F H C C L N P I L Y A F L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	3ODU	A	Protein	Chemokine	CXCR4	Homo sapiens	-	IT1t	-	2.5	2010-10-27	10.1126/science.1194396
	3OE0	A	Protein	Chemokine	CXCR4	Homo sapiens	-	CVX15	-	2.9	2010-10-27	10.1126/science.1194396
	3OE6	A	Protein	Chemokine	CXCR4	Homo sapiens	-	IT1t	-	3.2	2010-10-27	10.1126/science.1194396
	3OE8	A	Protein	Chemokine	CXCR4	Homo sapiens	-	IT1t	-	3.1	2010-10-27	10.1126/science.1194396
	3OE9	A	Protein	Chemokine	CXCR4	Homo sapiens	-	IT1t	-	3.1	2010-10-27	10.1126/science.1194396
	4RWS	A	Protein	Chemokine	CXCR4	Homo sapiens	vMIP-II	-	-	3.1	2015-02-11	10.1126/science.1261064
	8U4N	A	Protein	Chemokine	CXCR4	Homo sapiens	-	Cholesterol	Gi1/&β;1/&γ;2	2.72	2024-03-13	10.1101/2024.02.09.579708
	8U4O	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	Cholesterol	Gi1/&β;1/&γ;2	3.29	2024-03-13	10.1101/2024.02.09.579708
	8U4P	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	Cholesterol	Gi1/&β;1/&γ;2	3.15	2024-03-13	10.1101/2024.02.09.579708
	8U4Q	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	Cholesterol	Gi1/&β;1/&γ;2	3.36	2024-03-13	10.1101/2024.02.09.579708
	8U4R	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	Cholesterol	-	3.1	2024-03-13	10.1101/2024.02.09.579708
	3ODU (Dimer)	A	Protein	Chemokine	CXCR4	Homo sapiens	-	IT1t	-	2.5	2010-10-27	10.1126/science.1194396
	3OE8 (Dimer)	A	Protein	Chemokine	CXCR4	Homo sapiens	-	IT1t	-	3.1	2010-10-27	10.1126/science.1194396
	3OE9 (Dimer)	A	Protein	Chemokine	CXCR4	Homo sapiens	-	IT1t	-	3.1	2010-10-27	10.1126/science.1194396

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