psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W94	17.21	Yes	Yes	2	0	7
2	L:L:?1	R:R:D97	22.56	Yes	No	2	0	5
3	L:L:?1	R:R:W102	5.16	Yes	Yes	2	0	9
4	L:L:?1	R:R:H113	5.83	Yes	Yes	2	0	6
5	L:L:?1	R:R:Y116	10.63	Yes	Yes	2	0	6
6	L:L:?1	R:R:D187	3.08	Yes	No	0	0	3
7	L:L:?1	R:R:E288	17.02	Yes	Yes	2	0	5
8	M:M:?1	S:S:W94	12.05	Yes	Yes	1	0	5
9	M:M:?1	S:S:D97	20.51	Yes	No	1	0	5
10	M:M:?1	S:S:Y116	4.43	Yes	Yes	1	0	8
11	M:M:?1	S:S:R183	9.18	Yes	Yes	1	0	3
12	M:M:?1	S:S:I185	3.24	Yes	No	1	0	3
13	M:M:?1	S:S:D187	3.08	Yes	No	0	0	3
14	M:M:?1	S:S:R188	3.67	Yes	Yes	0	0	5
15	M:M:?1	S:S:E288	13.02	Yes	Yes	1	0	5
16	P:P:C274	P:P:C28	5.46	No	No	0	5	9
17	P:P:C28	P:P:E277	3.04	No	No	0	9	2
18	P:P:F36	P:P:F40	11.79	No	No	0	5	4
19	P:P:L41	P:P:N37	9.61	No	No	0	5	5
20	P:P:K282	P:P:N37	6.99	No	No	14	2	5
21	P:P:I286	P:P:N37	8.5	Yes	No	14	6	5
22	P:P:F40	P:P:I44	6.28	No	No	0	4	4
23	P:P:L41	P:P:Y45	4.69	No	Yes	0	5	7
24	P:P:L41	P:P:S285	3	No	No	0	5	5
25	P:P:P42	P:P:V99	3.53	No	No	0	7	9
26	P:P:A289	P:P:I44	4.87	No	No	0	4	4
27	P:P:I44	P:P:L290	7.14	No	No	0	4	7
28	P:P:L91	P:P:Y45	4.69	Yes	Yes	6	7	7
29	P:P:W94	P:P:Y45	6.75	Yes	Yes	6	5	7
30	P:P:A95	P:P:Y45	2.67	No	Yes	0	5	7
31	P:P:A289	P:P:Y45	5.34	No	Yes	0	4	7
32	P:P:F292	P:P:Y45	5.16	Yes	Yes	6	7	7
33	P:P:F293	P:P:I48	6.28	No	No	0	5	5
34	P:P:F49	P:P:L50	3.65	No	No	0	8	5
35	P:P:F49	P:P:I53	3.77	No	No	0	8	9
36	P:P:F49	P:P:P92	7.22	No	No	0	8	7
37	P:P:C296	P:P:T51	5.07	Yes	No	0	7	4
38	P:P:G52	P:P:V88	5.52	No	Yes	0	8	8
39	P:P:I53	P:P:L85	2.85	No	Yes	0	9	6
40	P:P:G55	P:P:P299	4.06	No	Yes	0	5	9
41	P:P:N56	P:P:S81	8.94	Yes	Yes	0	8	9
42	P:P:D84	P:P:N56	4.04	Yes	Yes	0	7	8
43	P:P:L85	P:P:N56	4.12	Yes	Yes	0	6	8
44	P:P:N56	P:P:V88	2.96	Yes	Yes	0	8	8
45	P:P:N56	P:P:P299	4.89	Yes	Yes	0	8	9
46	P:P:S81	P:P:V59	8.08	Yes	Yes	3	9	7
47	P:P:N298	P:P:V59	2.96	Yes	Yes	3	9	7
48	P:P:P299	P:P:V59	3.53	Yes	Yes	3	9	7
49	P:P:V59	P:P:Y302	3.79	Yes	Yes	3	7	9
50	P:P:I60	P:P:S81	3.1	No	Yes	0	6	9
51	P:P:I60	P:P:V82	4.61	No	No	0	6	7
52	P:P:I60	P:P:L85	2.85	No	Yes	0	6	6
53	P:P:M63	P:P:Q66	10.88	No	No	0	4	6
54	P:P:M63	P:P:Y302	4.79	No	Yes	0	4	9
55	P:P:L69	P:P:Q66	6.65	No	No	0	6	6
56	P:P:K67	P:P:R70	8.66	No	No	0	6	7
57	P:P:K68	P:P:L69	9.87	No	No	0	7	6
58	P:P:S71	P:P:T73	3.2	No	No	0	8	7
59	P:P:D74	P:P:S71	10.31	No	No	0	8	8
60	P:P:D133	P:P:M72	6.93	Yes	No	8	5	6
61	P:P:M72	P:P:R148	7.44	No	Yes	8	6	6
62	P:P:K149	P:P:M72	2.88	No	No	0	6	6
63	P:P:R134	P:P:T73	3.88	Yes	No	0	8	7
64	P:P:D74	P:P:Y302	10.34	No	Yes	0	8	9
65	P:P:H79	P:P:K75	2.62	Yes	No	0	5	5
66	P:P:E153	P:P:K75	9.45	No	No	0	7	5
67	P:P:F129	P:P:Y76	4.13	Yes	Yes	8	6	9
68	P:P:I130	P:P:Y76	4.84	No	Yes	0	8	9
69	P:P:D133	P:P:Y76	10.34	Yes	Yes	8	5	9
70	P:P:L151	P:P:Y76	4.69	No	Yes	8	4	9
71	P:P:A152	P:P:Y76	5.34	No	Yes	0	3	9
72	P:P:R77	P:P:T240	3.88	Yes	No	0	9	7
73	P:P:L244	P:P:R77	3.64	No	Yes	3	7	9
74	P:P:N298	P:P:R77	12.05	Yes	Yes	3	9	9
75	P:P:R77	P:P:Y302	30.87	Yes	Yes	3	9	9
76	P:P:H79	P:P:I126	2.65	Yes	Yes	0	5	5
77	P:P:H79	P:P:V156	12.45	Yes	No	15	5	5
78	P:P:H79	P:P:Y157	8.71	Yes	No	15	5	7
79	P:P:H79	P:P:W161	6.35	Yes	No	15	5	9
80	P:P:D84	P:P:L80	2.71	Yes	Yes	0	7	8
81	P:P:I126	P:P:L80	2.85	Yes	Yes	0	5	8
82	P:P:L127	P:P:L80	2.77	Yes	Yes	3	8	8
83	P:P:L244	P:P:L80	2.77	No	Yes	3	7	8
84	P:P:L80	P:P:N298	5.49	Yes	Yes	3	8	9
85	P:P:N298	P:P:S81	2.98	Yes	Yes	3	9	9
86	P:P:D84	P:P:N119	6.73	Yes	No	0	7	7
87	P:P:C295	P:P:D84	10.89	Yes	Yes	0	9	7
88	P:P:I89	P:P:L85	2.85	No	Yes	0	9	6
89	P:P:I115	P:P:L86	8.56	No	No	0	5	4
90	P:P:F87	P:P:L91	4.87	Yes	Yes	6	6	7
91	P:P:F87	P:P:W94	4.01	Yes	Yes	6	6	5
92	P:P:F87	P:P:Y116	8.25	Yes	Yes	6	6	8
93	P:P:F87	P:P:N119	16.92	Yes	No	0	6	7
94	P:P:F292	P:P:F87	11.79	Yes	Yes	6	7	6
95	P:P:C295	P:P:F87	2.79	Yes	Yes	0	9	6
96	P:P:L91	P:P:V88	2.98	Yes	Yes	0	7	8
97	P:P:C295	P:P:V88	3.42	Yes	Yes	0	9	8
98	P:P:T90	P:P:W94	3.64	No	Yes	0	6	5
99	P:P:T90	P:P:V112	4.76	No	No	0	6	5
100	P:P:I115	P:P:T90	6.08	No	No	0	5	6
101	P:P:L91	P:P:W94	3.42	Yes	Yes	6	7	5
102	P:P:F104	P:P:F93	12.86	Yes	No	0	1	5
103	P:P:F93	P:P:V112	5.24	No	No	0	5	5
104	P:P:W94	P:P:Y116	7.72	Yes	Yes	6	5	8
105	P:P:F292	P:P:W94	7.02	Yes	Yes	6	7	5
106	P:P:W94	U:U:?1	20.66	Yes	Yes	6	5	0
107	P:P:F104	P:P:V96	6.55	Yes	No	0	1	4
108	P:P:D97	P:P:W102	6.7	No	Yes	0	5	8
109	P:P:D97	U:U:?1	25.64	No	Yes	0	5	0
110	P:P:A100	P:P:Y103	4	No	No	0	3	3
111	P:P:N101	P:P:Y103	10.47	No	No	0	7	3
112	P:P:N101	P:P:R183	8.44	No	Yes	0	7	3
113	P:P:N101	P:P:Y184	10.47	No	No	0	7	5
114	P:P:F104	P:P:W102	21.05	Yes	Yes	0	1	8
115	P:P:G105	P:P:W102	2.81	No	Yes	0	5	8
116	P:P:C109	P:P:W102	3.92	Yes	Yes	9	5	8
117	P:P:V112	P:P:W102	6.13	No	Yes	0	5	8
118	P:P:V177	P:P:W102	3.68	Yes	Yes	9	4	8
119	P:P:C186	P:P:W102	16.98	No	Yes	9	9	8
120	P:P:K110	P:P:N106	2.8	No	No	9	6	9
121	P:P:N106	P:P:N176	12.26	No	No	9	9	4
122	P:P:N106	P:P:V177	2.96	No	Yes	9	9	4
123	P:P:F107	P:P:L108	4.87	No	No	0	7	4
124	P:P:C109	P:P:H113	2.95	Yes	Yes	9	5	6
125	P:P:C109	P:P:V177	3.42	Yes	Yes	9	5	4
126	P:P:C109	P:P:C186	7.28	Yes	No	9	5	9
127	P:P:K110	P:P:N176	4.2	No	No	9	6	4
128	P:P:A175	P:P:H113	5.85	No	Yes	0	4	6
129	P:P:C186	P:P:H113	2.95	No	Yes	9	9	6
130	P:P:H113	P:P:R188	5.64	Yes	Yes	0	6	5
131	P:P:T168	P:P:V114	9.52	Yes	No	17	6	5
132	P:P:F172	P:P:V114	14.42	No	No	17	4	5
133	P:P:L120	P:P:Y116	12.89	No	Yes	0	9	8
134	P:P:E288	P:P:Y116	6.73	Yes	Yes	6	5	8
135	P:P:F292	P:P:Y116	4.13	Yes	Yes	6	7	8
136	P:P:Y116	U:U:?1	7.97	Yes	Yes	6	8	0
137	P:P:T117	P:P:T168	7.85	No	Yes	0	7	6
138	P:P:D171	P:P:T117	10.12	No	No	0	4	7
139	P:P:T168	P:P:V118	4.76	Yes	No	0	6	7
140	P:P:H294	P:P:N119	5.1	Yes	No	0	9	7
141	P:P:H203	P:P:L120	5.14	No	No	0	4	9
142	P:P:L167	P:P:Y121	9.38	No	Yes	18	5	7
143	P:P:H203	P:P:Y121	6.53	No	Yes	0	4	7
144	P:P:V206	P:P:Y121	5.05	No	Yes	18	4	7
145	P:P:G207	P:P:Y121	2.9	No	Yes	0	5	7
146	P:P:I126	P:P:S122	3.1	Yes	No	0	5	5
147	P:P:F248	P:P:S123	3.96	Yes	No	3	9	7
148	P:P:H294	P:P:S123	5.58	Yes	No	3	9	7
149	P:P:P211	P:P:V124	5.3	No	No	0	9	8
150	P:P:F248	P:P:V124	5.24	Yes	No	3	9	8
151	P:P:F249	P:P:V124	2.62	No	No	3	4	8
152	P:P:A128	P:P:W125	3.89	No	No	0	9	7
153	P:P:V160	P:P:W125	3.68	No	No	0	7	7
154	P:P:P211	P:P:W125	20.27	No	No	0	9	7
155	P:P:I126	P:P:I130	2.94	Yes	No	0	5	8
156	P:P:L127	P:P:L244	2.77	Yes	No	3	8	7
157	P:P:I245	P:P:L127	8.56	No	Yes	3	7	8
158	P:P:F248	P:P:L127	8.53	Yes	Yes	3	9	8
159	P:P:A128	P:P:I215	3.25	No	No	0	9	7
160	P:P:F129	P:P:L151	7.31	Yes	No	8	6	4
161	P:P:F129	P:P:V155	5.24	Yes	No	8	6	2
162	P:P:F129	P:P:V160	5.24	Yes	No	0	6	7
163	P:P:I130	P:P:T241	4.56	No	No	0	8	7
164	P:P:I215	P:P:S131	6.19	No	Yes	3	7	9
165	P:P:C218	P:P:S131	3.44	No	Yes	0	6	9
166	P:P:S131	P:P:Y219	3.82	Yes	Yes	0	9	8
167	P:P:I245	P:P:S131	3.1	No	Yes	3	7	9
168	P:P:L132	P:P:V214	2.98	No	No	0	8	6
169	P:P:C218	P:P:L132	3.17	No	No	0	6	8
170	P:P:D133	P:P:R134	4.76	Yes	Yes	8	5	8
171	P:P:D133	P:P:R148	14.29	Yes	Yes	8	5	6
172	P:P:A137	P:P:R134	2.77	No	Yes	8	6	8
173	P:P:R134	P:P:R148	3.2	Yes	Yes	8	8	6
174	P:P:A237	P:P:R134	5.53	No	Yes	0	7	8
175	P:P:R134	P:P:T241	9.06	Yes	No	0	8	7
176	P:P:L136	P:P:Y135	4.69	No	Yes	0	7	8
177	P:P:V139	P:P:Y135	7.57	No	Yes	0	5	8
178	P:P:C218	P:P:Y135	2.69	No	Yes	0	6	8
179	P:P:I221	P:P:Y135	3.63	No	Yes	0	4	8
180	P:P:L136	P:P:P147	4.93	No	No	0	7	4
181	P:P:L136	P:P:R148	3.64	No	Yes	0	7	6
182	P:P:A137	P:P:R148	6.91	No	Yes	8	6	6
183	P:P:I138	P:P:I222	4.42	No	No	19	8	8
184	P:P:I138	P:P:L238	4.28	No	No	0	8	5
185	P:P:Q145	S:S:H140	8.65	No	No	0	5	5
186	P:P:E153	P:P:K149	4.05	No	No	0	7	6
187	P:P:K154	P:P:L150	2.82	No	No	0	3	4
188	P:P:L150	P:P:V155	2.98	No	No	0	4	2
189	P:P:L151	P:P:V155	4.47	No	No	8	4	2
190	P:P:V156	P:P:Y157	7.57	No	No	15	5	7
191	P:P:W161	P:P:Y157	2.89	No	No	15	9	7
192	P:P:G159	P:P:P163	4.06	No	No	0	3	4
193	P:P:I162	P:P:P163	3.39	No	No	0	4	4
194	P:P:L167	P:P:V206	4.47	No	No	18	5	4
195	P:P:F172	P:P:T168	3.89	No	Yes	17	4	6
196	P:P:I169	P:P:P170	3.39	No	No	0	3	8
197	P:P:F199	P:P:P170	10.11	Yes	No	0	5	8
198	P:P:D171	P:P:R188	9.53	No	Yes	0	4	5
199	P:P:F174	P:P:I173	8.79	Yes	No	0	4	3
200	P:P:F174	P:P:Y190	8.25	Yes	Yes	11	4	4
201	P:P:F174	P:P:P191	4.33	Yes	No	11	4	5
202	P:P:F174	P:P:W195	6.01	Yes	Yes	11	4	5
203	P:P:F174	P:P:F199	4.29	Yes	Yes	11	4	5
204	P:P:V177	P:P:Y184	3.79	Yes	No	0	4	5
205	P:P:F189	P:P:S178	6.61	No	No	0	3	1
206	P:P:E179	P:P:Y184	10.1	No	No	0	2	5
207	P:P:I185	P:P:R183	6.26	No	Yes	6	3	3
208	P:P:R183	U:U:?1	6.43	Yes	Yes	6	3	0
209	P:P:D187	P:P:I185	4.2	No	No	6	3	3
210	P:P:I185	U:U:?1	3.24	No	Yes	6	3	0
211	P:P:D187	P:P:F189	13.14	No	No	0	3	3
212	P:P:D187	U:U:?1	3.08	No	Yes	6	3	0
213	P:P:R188	P:P:Y190	14.4	Yes	Yes	0	5	4
214	P:P:R188	U:U:?1	3.67	Yes	Yes	0	5	0
215	P:P:W195	P:P:Y190	2.89	Yes	Yes	11	5	4
216	P:P:V196	P:P:Y190	6.31	No	Yes	0	4	4
217	P:P:F199	P:P:Y190	6.19	Yes	Yes	11	5	4
218	P:P:P191	P:P:W195	14.86	No	Yes	11	5	5
219	P:P:L194	P:P:N192	6.87	No	No	0	2	1
220	P:P:N192	P:P:W195	6.78	No	Yes	0	1	5
221	P:P:L194	S:S:V197	5.96	No	No	0	2	3
222	P:P:F199	P:P:W195	5.01	Yes	Yes	11	5	5
223	P:P:V197	S:S:L194	7.45	No	No	0	3	2
224	P:P:V197	S:S:V197	3.21	No	No	0	3	3
225	P:P:V198	S:S:F201	2.62	No	No	0	3	4
226	P:P:F199	P:P:Q202	3.51	Yes	No	0	5	3
227	P:P:H203	P:P:Q200	3.71	No	No	0	4	5
228	P:P:I204	P:P:Q200	4.12	No	No	0	5	5
229	P:P:F201	S:S:V198	2.62	No	No	0	4	3
230	P:P:F201	S:S:F201	6.43	No	No	0	4	4
231	P:P:F201	S:S:Q202	8.2	No	No	0	4	3
232	P:P:Q202	S:S:F201	8.2	No	No	0	3	4
233	P:P:L210	P:P:M205	5.65	No	No	0	6	4
234	P:P:M205	S:S:M205	7.22	No	No	0	4	4
235	P:P:L208	P:P:Y256	19.93	No	No	0	8	8
236	P:P:L210	S:S:L210	9.69	No	No	0	6	6
237	P:P:I215	P:P:I245	2.94	No	No	3	7	7
238	P:P:L238	P:P:Y219	3.52	No	Yes	0	5	8
239	P:P:T241	P:P:Y219	4.99	No	Yes	0	7	8
240	P:P:V242	P:P:Y219	5.05	No	Yes	0	4	8
241	P:P:G231	P:P:K234	3.49	No	No	0	4	7
242	P:P:K239	P:P:R235	4.95	No	No	0	6	5
243	P:P:K236	P:P:L305	4.23	No	No	0	8	6
244	P:P:L305	P:P:T240	7.37	No	No	0	6	7
245	P:P:I243	P:P:L301	5.71	No	No	0	5	7
246	P:P:A247	P:P:L297	4.73	No	No	0	6	6
247	P:P:F248	P:P:F249	9.65	Yes	No	3	9	4
248	P:P:F248	P:P:W252	10.02	Yes	Yes	3	9	9
249	P:P:F248	P:P:H294	9.05	Yes	Yes	3	9	9
250	P:P:F249	P:P:Y256	3.09	No	No	0	4	8
251	P:P:C251	P:P:L297	4.76	No	No	0	8	6
252	P:P:W252	P:P:Y255	9.65	Yes	Yes	0	9	7
253	P:P:W252	P:P:Y256	7.72	Yes	No	0	9	8
254	P:P:A291	P:P:W252	9.08	No	Yes	0	8	9
255	P:P:H294	P:P:W252	14.81	Yes	Yes	3	9	9
256	P:P:L253	P:P:P254	3.28	No	No	0	5	9
257	P:P:I257	P:P:L253	4.28	No	No	0	6	5
258	P:P:P254	P:P:T287	3.5	No	No	0	9	6
259	P:P:I259	P:P:Y255	12.09	No	Yes	0	5	7
260	P:P:T287	P:P:Y255	4.99	No	Yes	0	6	7
261	P:P:E288	P:P:Y255	8.98	Yes	Yes	0	5	7
262	P:P:I259	P:P:I284	2.94	No	Yes	0	5	4
263	P:P:D262	P:P:I265	7	Yes	No	0	5	3
264	P:P:D262	P:P:V280	2.92	Yes	Yes	21	5	5
265	P:P:D262	P:P:H281	12.61	Yes	No	0	5	4
266	P:P:D262	P:P:I284	5.6	Yes	Yes	21	5	4
267	P:P:F264	P:P:I269	5.02	No	No	0	4	1
268	P:P:L267	S:S:W195	12.53	No	Yes	0	1	5
269	P:P:E268	S:S:P191	3.14	No	No	0	2	5
270	P:P:I270	P:P:Q272	2.74	No	No	0	5	2
271	P:P:F276	P:P:Q272	12.88	No	No	0	1	2
272	P:P:F276	P:P:V280	2.62	No	Yes	0	1	5
273	P:P:I284	P:P:V280	3.07	Yes	Yes	21	4	5
274	P:P:K282	P:P:W283	4.64	No	No	14	2	6
275	P:P:I286	P:P:K282	2.91	Yes	No	14	6	2
276	P:P:I286	P:P:W283	8.22	Yes	No	14	6	6
277	P:P:I286	P:P:L290	2.85	Yes	No	0	6	7
278	P:P:E288	P:P:F292	7	Yes	Yes	6	5	7
279	P:P:E288	U:U:?1	14.02	Yes	Yes	6	5	0
280	P:P:C296	P:P:F293	6.98	Yes	No	0	7	5
281	P:P:C295	P:P:H294	5.9	Yes	Yes	0	9	9
282	P:P:N298	P:P:P299	6.52	Yes	Yes	3	9	9
283	P:P:N298	P:P:Y302	6.98	Yes	Yes	3	9	9
284	P:P:L301	P:P:L305	2.77	No	No	0	7	6
285	R:R:C274	R:R:C28	7.28	No	No	0	5	9
286	R:R:C28	R:R:E277	10.64	No	No	0	9	2
287	R:R:N35	S:S:F276	6.04	No	Yes	0	3	1
288	R:R:N35	S:S:T279	2.92	No	No	0	3	2
289	R:R:F36	R:R:F40	5.36	No	No	0	4	5
290	R:R:F36	S:S:W283	10.02	No	No	0	4	6
291	R:R:L41	R:R:N37	6.87	No	No	0	6	3
292	R:R:N37	R:R:S285	2.98	No	No	0	3	5
293	R:R:K38	S:S:Q272	5.42	No	No	0	4	2
294	R:R:K38	S:S:F276	16.13	No	Yes	0	4	1
295	R:R:I39	S:S:I261	5.89	No	No	22	5	5
296	R:R:I39	S:S:V280	4.61	No	Yes	22	5	5
297	R:R:F40	R:R:I44	7.54	No	No	0	5	5
298	R:R:T43	S:S:I257	3.04	No	Yes	0	4	6
299	R:R:A289	R:R:I44	4.87	No	No	0	4	5
300	R:R:L91	R:R:Y45	4.69	Yes	Yes	0	8	7
301	R:R:W94	R:R:Y45	8.68	Yes	Yes	2	7	7
302	R:R:A95	R:R:Y45	2.67	No	Yes	0	7	7
303	R:R:A289	R:R:Y45	2.67	No	Yes	0	4	7
304	R:R:F292	R:R:Y45	5.16	Yes	Yes	2	7	7
305	R:R:S46	S:S:I257	6.19	No	Yes	0	5	6
306	R:R:I47	S:S:L253	4.28	No	No	0	4	5
307	R:R:I48	R:R:L91	2.85	No	Yes	0	7	8
308	R:R:F49	R:R:I53	5.02	Yes	No	0	6	5
309	R:R:F49	R:R:P92	7.22	Yes	No	0	6	9
310	R:R:C296	R:R:T51	5.07	No	No	0	7	5
311	R:R:V54	S:S:L216	5.96	No	No	0	4	4
312	R:R:G55	R:R:P299	4.06	No	Yes	0	8	9
313	R:R:N56	R:R:S81	5.96	Yes	No	0	9	9
314	R:R:D84	R:R:N56	6.73	Yes	Yes	0	9	9
315	R:R:L85	R:R:N56	2.75	No	Yes	0	7	9
316	R:R:N56	R:R:P299	11.4	Yes	Yes	0	9	9
317	R:R:L58	S:S:C220	3.17	No	No	0	5	3
318	R:R:L58	S:S:I223	8.56	No	No	0	5	4
319	R:R:S81	R:R:V59	6.46	No	No	0	9	8
320	R:R:P299	R:R:V59	3.53	Yes	No	0	9	8
321	R:R:V59	R:R:Y302	5.05	No	Yes	0	8	9
322	R:R:I60	R:R:S81	4.64	No	No	0	7	9
323	R:R:I60	R:R:V82	3.07	No	No	0	7	5
324	R:R:I60	R:R:L85	4.28	No	No	0	7	7
325	R:R:V62	S:S:I223	3.07	No	No	0	7	4
326	R:R:K67	R:R:M63	8.64	No	Yes	10	6	6
327	R:R:M63	R:R:R70	6.2	Yes	Yes	10	6	6
328	R:R:D74	R:R:M63	8.32	Yes	Yes	10	8	6
329	R:R:M63	R:R:Y302	7.18	Yes	Yes	10	6	9
330	R:R:G64	R:R:Y65	4.35	No	No	0	2	5
331	R:R:Q66	S:S:S224	5.78	No	No	0	4	4
332	R:R:D74	R:R:K67	2.77	Yes	No	10	8	6
333	R:R:D74	R:R:R70	3.57	Yes	Yes	10	8	6
334	R:R:K75	R:R:R70	14.85	No	Yes	0	6	6
335	R:R:D74	R:R:S71	5.89	Yes	No	0	8	7
336	R:R:D133	R:R:M72	6.93	Yes	No	4	8	6
337	R:R:M72	R:R:R148	9.93	No	Yes	4	6	6
338	R:R:K149	R:R:M72	2.88	No	No	0	6	6
339	R:R:R134	R:R:T73	3.88	Yes	No	0	9	7
340	R:R:D74	R:R:Y302	6.9	Yes	Yes	10	8	9
341	R:R:F129	R:R:Y76	8.25	Yes	Yes	4	5	7
342	R:R:I130	R:R:Y76	4.84	No	Yes	0	8	7
343	R:R:D133	R:R:Y76	4.6	Yes	Yes	4	8	7
344	R:R:L151	R:R:Y76	3.52	No	Yes	4	4	7
345	R:R:A152	R:R:Y76	5.34	No	Yes	0	3	7
346	R:R:V156	R:R:Y76	3.79	Yes	Yes	4	5	7
347	R:R:R77	R:R:T240	3.88	No	No	0	8	7
348	R:R:N298	R:R:R77	12.05	Yes	No	10	9	8
349	R:R:R77	R:R:Y302	29.84	No	Yes	10	8	9
350	R:R:H79	R:R:I126	2.65	Yes	No	0	9	7
351	R:R:H79	R:R:V156	6.92	Yes	Yes	4	9	5
352	R:R:H79	R:R:Y157	13.07	Yes	No	4	9	7
353	R:R:H79	R:R:W161	9.52	Yes	No	4	9	9
354	R:R:D84	R:R:L80	4.07	Yes	No	0	9	9
355	R:R:I126	R:R:L80	5.71	No	No	0	7	9
356	R:R:L244	R:R:L80	2.77	Yes	No	0	7	9
357	R:R:D84	R:R:N119	5.39	Yes	No	0	9	8
358	R:R:C295	R:R:D84	9.34	Yes	Yes	0	9	9
359	R:R:F87	R:R:L91	4.87	Yes	Yes	0	7	8
360	R:R:F87	R:R:W94	5.01	Yes	Yes	2	7	7
361	R:R:F87	R:R:Y116	7.22	Yes	Yes	2	7	6
362	R:R:F87	R:R:N119	12.08	Yes	No	0	7	8
363	R:R:F292	R:R:F87	16.08	Yes	Yes	2	7	7
364	R:R:C295	R:R:F87	2.79	Yes	Yes	0	9	7
365	R:R:L91	R:R:V88	2.98	Yes	No	0	8	6
366	R:R:C295	R:R:V88	3.42	Yes	No	0	9	6
367	R:R:T90	R:R:V112	4.76	No	No	0	6	5
368	R:R:I115	R:R:T90	4.56	No	No	0	5	6
369	R:R:F104	R:R:F93	11.79	No	No	0	7	6
370	R:R:F93	R:R:L108	4.87	No	No	0	6	5
371	R:R:F93	R:R:V112	3.93	No	No	0	6	5
372	R:R:W94	R:R:Y116	5.79	Yes	Yes	2	7	6
373	R:R:E288	R:R:W94	5.45	Yes	Yes	2	5	7
374	R:R:F292	R:R:W94	8.02	Yes	Yes	2	7	7
375	R:R:F104	R:R:V96	6.55	No	No	0	7	5
376	R:R:D97	R:R:W102	6.7	No	Yes	2	5	9
377	R:R:V99	S:S:F276	2.62	No	Yes	0	4	1
378	R:R:A100	R:R:Y103	4	No	No	0	5	3
379	R:R:N101	R:R:Y103	10.47	No	No	0	4	3
380	R:R:N101	R:R:R183	3.62	No	Yes	0	4	3
381	R:R:N101	R:R:Y184	3.49	No	No	0	4	5
382	R:R:F104	R:R:W102	11.02	No	Yes	0	7	9
383	R:R:G105	R:R:W102	2.81	No	Yes	0	8	9
384	R:R:C109	R:R:W102	6.53	No	Yes	2	9	9
385	R:R:V177	R:R:W102	8.58	Yes	Yes	2	4	9
386	R:R:C186	R:R:W102	15.67	No	Yes	2	9	9
387	R:R:N106	R:R:N176	6.81	No	No	0	3	4
388	R:R:N106	R:R:V177	5.91	No	Yes	0	3	4
389	R:R:C109	R:R:V177	3.42	No	Yes	2	9	4
390	R:R:C109	R:R:C186	7.28	No	No	2	9	9
391	R:R:K110	R:R:N176	5.6	No	No	0	7	4
392	R:R:D171	R:R:H113	6.3	No	Yes	2	4	6
393	R:R:A175	R:R:H113	5.85	No	Yes	0	4	6
394	R:R:C186	R:R:H113	2.95	No	Yes	2	9	6
395	R:R:H113	R:R:R188	9.03	Yes	No	2	6	5
396	R:R:T168	R:R:V114	9.52	Yes	No	23	6	5
397	R:R:F172	R:R:V114	15.73	No	No	23	4	5
398	R:R:L120	R:R:Y116	8.21	No	Yes	0	7	6
399	R:R:E288	R:R:Y116	7.86	Yes	Yes	2	5	6
400	R:R:F292	R:R:Y116	4.13	Yes	Yes	2	7	6
401	R:R:T117	R:R:T168	6.28	No	Yes	0	5	6
402	R:R:D171	R:R:T117	13.01	No	No	0	4	5
403	R:R:T168	R:R:V118	4.76	Yes	No	0	6	5
404	R:R:H294	R:R:N119	5.1	Yes	No	0	9	8
405	R:R:H203	R:R:L120	12.86	Yes	No	0	4	7
406	R:R:L120	R:R:W252	3.42	No	Yes	0	7	9
407	R:R:L167	R:R:Y121	10.55	No	Yes	2	5	7
408	R:R:Q202	R:R:Y121	4.51	No	Yes	2	3	7
409	R:R:H203	R:R:Y121	4.36	Yes	Yes	2	4	7
410	R:R:V206	R:R:Y121	5.05	No	Yes	0	4	7
411	R:R:G207	R:R:Y121	2.9	No	Yes	0	5	7
412	R:R:S122	R:R:W161	6.18	No	No	0	7	9
413	R:R:F248	R:R:S123	6.61	Yes	No	2	9	9
414	R:R:H294	R:R:S123	2.79	Yes	No	2	9	9
415	R:R:V124	R:R:W125	3.68	Yes	Yes	2	7	5
416	R:R:P211	R:R:V124	8.84	No	Yes	2	9	7
417	R:R:F248	R:R:V124	3.93	Yes	Yes	2	9	7
418	R:R:F249	R:R:V124	3.93	No	Yes	0	4	7
419	R:R:A128	R:R:W125	3.89	No	Yes	0	7	5
420	R:R:P211	R:R:W125	22.97	No	Yes	2	9	5
421	R:R:V214	R:R:W125	4.9	No	Yes	0	6	5
422	R:R:I126	R:R:V160	3.07	No	No	0	7	7
423	R:R:L127	R:R:L244	2.77	No	Yes	0	8	7
424	R:R:I245	R:R:L127	2.85	No	No	0	7	8
425	R:R:F248	R:R:L127	8.53	Yes	No	0	9	8
426	R:R:A128	R:R:I215	3.25	No	No	0	7	7
427	R:R:F129	R:R:L151	6.09	Yes	No	4	5	4
428	R:R:F129	R:R:V155	5.24	Yes	No	4	5	2
429	R:R:F129	R:R:V156	6.55	Yes	Yes	4	5	5
430	R:R:F129	R:R:V160	5.24	Yes	No	4	5	7
431	R:R:I130	R:R:T241	4.56	No	No	0	8	7
432	R:R:I215	R:R:S131	9.29	No	No	0	7	9
433	R:R:C218	R:R:S131	3.44	No	No	0	6	9
434	R:R:S131	R:R:Y219	5.09	No	Yes	0	9	8
435	R:R:D133	R:R:R134	3.57	Yes	Yes	4	8	9
436	R:R:D133	R:R:R148	19.06	Yes	Yes	4	8	6
437	R:R:R134	R:R:R148	4.26	Yes	Yes	4	9	6
438	R:R:L238	R:R:R134	3.64	No	Yes	0	5	9
439	R:R:R134	R:R:T241	5.17	Yes	No	0	9	7
440	R:R:V139	R:R:Y135	12.62	Yes	Yes	24	7	8
441	R:R:H140	R:R:Y135	8.71	No	Yes	24	6	8
442	R:R:C218	R:R:Y135	2.69	No	Yes	0	6	8
443	R:R:I221	R:R:Y135	3.63	No	Yes	0	4	8
444	R:R:L136	R:R:P147	6.57	No	No	0	5	4
445	R:R:L136	R:R:R148	3.64	No	Yes	0	5	6
446	R:R:A137	R:R:R148	6.91	No	Yes	0	8	6
447	R:R:I138	R:R:V139	3.07	No	Yes	0	8	7
448	R:R:H140	R:R:V139	8.3	No	Yes	24	6	7
449	R:R:K225	R:R:V139	3.04	No	Yes	0	4	7
450	R:R:H140	R:R:N143	3.83	No	No	0	6	5
451	R:R:N143	R:R:T142	5.85	No	No	0	5	5
452	R:R:P147	R:R:S144	5.34	No	No	0	4	5
453	R:R:R148	R:R:S144	2.64	Yes	No	0	6	5
454	R:R:Q145	R:R:R146	3.5	No	No	0	5	5
455	R:R:E153	R:R:K149	14.85	No	No	0	7	6
456	R:R:K154	R:R:L150	4.23	No	No	0	3	4
457	R:R:L151	R:R:V155	5.96	No	No	4	4	2
458	R:R:V156	R:R:Y157	5.05	Yes	No	4	5	7
459	R:R:V156	R:R:V160	3.21	Yes	No	4	5	7
460	R:R:W161	R:R:Y157	2.89	No	No	4	9	7
461	R:R:G159	R:R:P163	4.06	No	No	0	3	4
462	R:R:I162	R:R:P163	5.08	No	No	0	4	4
463	R:R:L167	R:R:Q202	2.66	No	No	2	5	3
464	R:R:F172	R:R:T168	3.89	No	Yes	23	4	6
465	R:R:I169	R:R:P170	3.39	No	No	0	3	8
466	R:R:F199	R:R:P170	7.22	Yes	No	0	5	8
467	R:R:D171	R:R:R188	10.72	No	No	2	4	5
468	R:R:F174	R:R:I173	11.3	Yes	No	0	4	3
469	R:R:F174	R:R:Y190	12.38	Yes	Yes	2	4	4
470	R:R:F174	R:R:P191	2.89	Yes	No	2	4	5
471	R:R:F174	R:R:W195	5.01	Yes	Yes	2	4	5
472	R:R:V177	R:R:Y184	3.79	Yes	No	0	4	5
473	R:R:I185	R:R:S178	3.1	No	No	0	3	1
474	R:R:F189	R:R:S178	6.61	No	No	0	3	1
475	R:R:E179	R:R:Y184	20.2	No	No	0	2	5
476	R:R:A180	R:R:D181	3.09	No	No	16	1	2
477	R:R:A180	R:R:R183	5.53	No	Yes	16	1	3
478	R:R:A180	R:R:I185	3.25	No	No	16	1	3
479	R:R:D181	R:R:R183	8.34	No	Yes	16	2	3
480	R:R:I185	R:R:R183	8.77	No	Yes	16	3	3
481	R:R:D187	R:R:F189	10.75	No	No	0	3	3
482	R:R:R188	R:R:Y190	14.4	No	Yes	2	5	4
483	R:R:W195	R:R:Y190	4.82	Yes	Yes	2	5	4
484	R:R:V196	R:R:Y190	3.79	No	Yes	0	4	4
485	R:R:F199	R:R:Y190	11.35	Yes	Yes	2	5	4
486	R:R:P191	R:R:W195	22.97	No	Yes	2	5	5
487	R:R:L194	R:R:N192	5.49	No	No	0	2	1
488	R:R:N192	R:R:W195	5.65	No	Yes	0	1	5
489	R:R:D193	R:R:L266	4.07	No	Yes	0	1	3
490	R:R:F199	R:R:W195	3.01	Yes	Yes	2	5	5
491	R:R:Q200	R:R:V196	2.87	Yes	No	0	5	4
492	R:R:F201	R:R:V197	5.24	No	No	0	4	3
493	R:R:L266	R:R:V197	4.47	Yes	No	0	3	3
494	R:R:F199	R:R:Q202	5.86	Yes	No	2	5	3
495	R:R:I259	R:R:Q200	9.61	Yes	Yes	0	5	5
496	R:R:D262	R:R:Q200	9.14	No	Yes	0	5	5
497	R:R:Q200	R:R:S263	7.22	Yes	No	0	5	5
498	R:R:F201	R:R:S263	6.61	No	No	0	4	5
499	R:R:H203	R:R:Y255	7.62	Yes	Yes	2	4	7
500	R:R:H203	R:R:Y256	13.07	Yes	Yes	2	4	8
501	R:R:I204	R:R:I209	2.94	Yes	No	0	5	4
502	R:R:I204	R:R:Y256	4.84	Yes	Yes	0	5	8
503	R:R:I204	R:R:I259	2.94	Yes	Yes	0	5	5
504	R:R:I204	R:R:S260	3.1	Yes	No	0	5	5
505	R:R:I209	R:R:M205	5.83	No	No	0	4	4
506	R:R:L210	R:R:M205	7.07	No	No	0	6	4
507	R:R:L208	R:R:L253	2.77	No	No	0	8	5
508	R:R:L208	R:R:Y256	10.55	No	Yes	0	8	8
509	R:R:I215	R:R:I245	4.42	No	No	0	7	7
510	R:R:T241	R:R:Y219	3.75	No	Yes	0	7	8
511	R:R:V242	R:R:Y219	3.79	No	Yes	0	4	8
512	R:R:I245	R:R:Y219	3.63	No	Yes	0	7	8
513	R:R:I222	R:R:L238	2.85	No	No	0	8	5
514	R:R:H228	R:R:K225	2.62	No	No	0	5	4
515	R:R:L226	R:R:R235	8.5	Yes	No	0	8	5
516	R:R:K236	R:R:Q233	8.14	No	No	0	8	5
517	R:R:L305	R:R:T240	7.37	No	No	0	6	7
518	R:R:I243	R:R:L301	4.28	No	No	0	5	7
519	R:R:L244	R:R:N298	2.75	Yes	Yes	0	7	9
520	R:R:L244	R:R:L301	2.77	Yes	No	0	7	7
521	R:R:A247	R:R:L297	4.73	No	No	0	6	6
522	R:R:F248	R:R:W252	10.02	Yes	Yes	2	9	9
523	R:R:F248	R:R:H294	9.05	Yes	Yes	2	9	9
524	R:R:W252	R:R:Y255	7.72	Yes	Yes	2	9	7
525	R:R:W252	R:R:Y256	6.75	Yes	Yes	2	9	8
526	R:R:A291	R:R:W252	9.08	No	Yes	0	8	9
527	R:R:F292	R:R:W252	4.01	Yes	Yes	2	7	9
528	R:R:H294	R:R:W252	12.7	Yes	Yes	2	9	9
529	R:R:P254	R:R:T287	3.5	No	No	0	9	6
530	R:R:Y255	R:R:Y256	2.98	Yes	Yes	2	7	8
531	R:R:I259	R:R:Y255	10.88	Yes	Yes	0	5	7
532	R:R:T287	R:R:Y255	3.75	No	Yes	0	6	7
533	R:R:E288	R:R:Y255	13.47	Yes	Yes	2	5	7
534	R:R:G258	R:R:W283	2.81	No	No	0	4	6
535	R:R:G258	R:R:I284	3.53	No	No	0	4	4
536	R:R:I259	R:R:I284	4.42	Yes	No	0	5	4
537	R:R:I261	R:R:I270	4.42	No	Yes	0	5	5
538	R:R:I261	R:R:V280	6.14	No	No	0	5	5
539	R:R:D262	R:R:L266	2.71	No	Yes	0	5	3
540	R:R:D262	R:R:I284	4.2	No	No	0	5	4
541	R:R:I265	R:R:L266	2.85	No	Yes	0	3	3
542	R:R:I265	R:R:I270	5.89	No	Yes	0	3	5
543	R:R:I269	R:R:L267	2.85	No	No	0	1	1
544	R:R:I270	R:R:Q272	2.74	Yes	No	0	5	2
545	R:R:F276	R:R:Q272	10.54	No	No	0	1	2
546	R:R:F276	R:R:V280	7.87	No	No	0	1	5
547	R:R:K282	R:R:N278	2.8	No	No	0	2	3
548	R:R:T287	R:R:W283	13.34	No	No	0	6	6
549	R:R:I286	R:R:L290	2.85	No	No	0	6	7
550	R:R:E288	R:R:F292	7	Yes	Yes	2	5	7
551	R:R:C296	R:R:F293	5.59	No	No	0	7	5
552	R:R:C295	R:R:H294	5.9	Yes	Yes	0	9	9
553	R:R:N298	R:R:P299	3.26	Yes	Yes	0	9	9
554	R:R:N298	R:R:Y302	5.81	Yes	Yes	10	9	9
555	R:R:F304	R:R:I300	3.77	No	No	0	6	6
556	S:S:C274	S:S:C28	7.28	No	No	0	5	9
557	S:S:F36	S:S:N37	3.62	No	Yes	0	5	5
558	S:S:F36	S:S:F40	10.72	No	Yes	0	5	4
559	S:S:L41	S:S:N37	4.12	No	Yes	1	5	5
560	S:S:K282	S:S:N37	5.6	No	Yes	0	2	5
561	S:S:N37	S:S:S285	2.98	Yes	No	1	5	5
562	S:S:I286	S:S:N37	4.25	Yes	Yes	1	6	5
563	S:S:F40	S:S:I44	11.3	Yes	No	0	4	4
564	S:S:F40	S:S:I286	6.28	Yes	Yes	1	4	6
565	S:S:F40	S:S:L290	3.65	Yes	No	1	4	7
566	S:S:L41	S:S:Y45	8.21	No	Yes	1	5	7
567	S:S:L41	S:S:S285	3	No	No	1	5	5
568	S:S:P42	S:S:V99	5.3	No	No	0	7	9
569	S:S:L91	S:S:Y45	4.69	Yes	Yes	1	7	7
570	S:S:W94	S:S:Y45	8.68	Yes	Yes	1	5	7
571	S:S:A95	S:S:Y45	2.67	No	Yes	0	5	7
572	S:S:A289	S:S:Y45	4	No	Yes	0	4	7
573	S:S:F292	S:S:Y45	4.13	Yes	Yes	1	7	7
574	S:S:I48	S:S:L91	2.85	No	Yes	0	5	7
575	S:S:F49	S:S:L50	3.65	No	No	0	8	5
576	S:S:F49	S:S:P92	8.67	No	No	0	8	7
577	S:S:C296	S:S:T51	5.07	No	No	0	7	4
578	S:S:G52	S:S:V88	5.52	No	Yes	0	8	8
579	S:S:G55	S:S:P299	4.06	No	Yes	0	5	9
580	S:S:N56	S:S:S81	5.96	Yes	Yes	0	8	9
581	S:S:D84	S:S:N56	4.04	Yes	Yes	0	7	8
582	S:S:L85	S:S:N56	2.75	No	Yes	0	6	8
583	S:S:N56	S:S:P299	6.52	Yes	Yes	0	8	9
584	S:S:M63	S:S:V59	3.04	Yes	Yes	7	4	7
585	S:S:S81	S:S:V59	8.08	Yes	Yes	7	9	7
586	S:S:N298	S:S:V59	2.96	Yes	Yes	7	9	7
587	S:S:P299	S:S:V59	3.53	Yes	Yes	7	9	7
588	S:S:I60	S:S:S81	3.1	Yes	Yes	0	6	9
589	S:S:I60	S:S:V82	3.07	Yes	No	0	6	7
590	S:S:I60	S:S:L85	5.71	Yes	No	0	6	6
591	S:S:K67	S:S:M63	8.64	No	Yes	0	6	4
592	S:S:M63	S:S:R70	4.96	Yes	No	7	4	7
593	S:S:D74	S:S:M63	2.77	No	Yes	7	8	4
594	S:S:L78	S:S:M63	5.65	No	Yes	7	9	4
595	S:S:M63	S:S:Y302	4.79	Yes	Yes	7	4	9
596	S:S:G64	S:S:Y65	4.35	No	No	0	6	6
597	S:S:K75	S:S:R70	8.66	No	No	0	5	7
598	S:S:L78	S:S:R70	8.5	No	No	7	9	7
599	S:S:S71	S:S:T73	3.2	No	Yes	0	8	7
600	S:S:D74	S:S:S71	5.89	No	No	0	8	8
601	S:S:D133	S:S:M72	9.7	Yes	No	5	5	6
602	S:S:M72	S:S:R148	8.69	No	Yes	5	6	6
603	S:S:A152	S:S:M72	3.22	No	No	0	3	6
604	S:S:I130	S:S:T73	4.56	Yes	Yes	5	8	7
605	S:S:R134	S:S:T73	5.17	No	Yes	0	8	7
606	S:S:T241	S:S:T73	3.14	No	Yes	5	7	7
607	S:S:D74	S:S:Y302	5.75	No	Yes	7	8	9
608	S:S:F129	S:S:Y76	10.32	Yes	Yes	5	6	9
609	S:S:I130	S:S:Y76	6.04	Yes	Yes	5	8	9
610	S:S:D133	S:S:Y76	8.05	Yes	Yes	5	5	9
611	S:S:L151	S:S:Y76	3.52	Yes	Yes	5	4	9
612	S:S:A152	S:S:Y76	5.34	No	Yes	0	3	9
613	S:S:V156	S:S:Y76	3.79	No	Yes	5	5	9
614	S:S:L244	S:S:R77	3.64	No	Yes	0	7	9
615	S:S:N298	S:S:R77	12.05	Yes	Yes	7	9	9
616	S:S:L301	S:S:R77	6.07	No	Yes	0	7	9
617	S:S:R77	S:S:Y302	30.87	Yes	Yes	7	9	9
618	S:S:H79	S:S:V156	6.92	No	No	5	5	5
619	S:S:H79	S:S:Y157	7.62	No	No	5	5	7
620	S:S:H79	S:S:W161	6.35	No	No	0	5	9
621	S:S:D84	S:S:L80	2.71	Yes	No	0	7	8
622	S:S:I126	S:S:L80	7.14	No	No	0	5	8
623	S:S:L80	S:S:N298	5.49	No	Yes	0	8	9
624	S:S:N298	S:S:S81	2.98	Yes	Yes	7	9	9
625	S:S:A83	S:S:S122	3.42	No	No	0	7	5
626	S:S:D84	S:S:N119	6.73	Yes	No	1	7	7
627	S:S:D84	S:S:H294	7.56	Yes	Yes	1	7	9
628	S:S:C295	S:S:D84	9.34	Yes	Yes	1	9	7
629	S:S:I115	S:S:L86	2.85	No	No	0	5	4
630	S:S:F87	S:S:T90	3.89	Yes	No	0	6	6
631	S:S:F87	S:S:L91	6.09	Yes	Yes	1	6	7
632	S:S:F87	S:S:W94	5.01	Yes	Yes	1	6	5
633	S:S:F87	S:S:Y116	8.25	Yes	Yes	1	6	8
634	S:S:F87	S:S:N119	8.46	Yes	No	1	6	7
635	S:S:F292	S:S:F87	13.93	Yes	Yes	1	7	6
636	S:S:C295	S:S:F87	2.79	Yes	Yes	1	9	6
637	S:S:L91	S:S:V88	2.98	Yes	Yes	0	7	8
638	S:S:C295	S:S:V88	3.42	Yes	Yes	0	9	8
639	S:S:T90	S:S:V112	3.17	No	No	0	6	5
640	S:S:I115	S:S:T90	6.08	No	No	0	5	6
641	S:S:L91	S:S:W94	4.56	Yes	Yes	1	7	5
642	S:S:F104	S:S:F93	17.15	No	No	0	1	5
643	S:S:F93	S:S:L108	4.87	No	No	0	5	4
644	S:S:F93	S:S:V112	5.24	No	No	0	5	5
645	S:S:W94	S:S:Y116	9.65	Yes	Yes	1	5	8
646	S:S:E288	S:S:W94	6.54	Yes	Yes	1	5	5
647	S:S:F292	S:S:W94	7.02	Yes	Yes	1	7	5
648	S:S:F104	S:S:V96	6.55	No	No	0	1	4
649	S:S:D97	S:S:W102	4.47	No	Yes	1	5	8
650	S:S:D97	S:S:R183	7.15	No	Yes	1	5	3
651	S:S:A100	S:S:Y103	4	No	No	0	3	3
652	S:S:N101	S:S:Y103	8.14	No	No	0	7	3
653	S:S:N101	S:S:R183	8.44	No	Yes	0	7	3
654	S:S:N101	S:S:Y184	11.63	No	No	0	7	5
655	S:S:F104	S:S:W102	12.03	No	Yes	0	1	8
656	S:S:C109	S:S:W102	3.92	Yes	Yes	1	5	8
657	S:S:V177	S:S:W102	4.9	Yes	Yes	1	4	8
658	S:S:C186	S:S:W102	19.59	No	Yes	1	9	8
659	S:S:K110	S:S:N106	2.8	No	No	1	6	9
660	S:S:N106	S:S:N176	8.17	No	No	1	9	4
661	S:S:N106	S:S:V177	7.39	No	Yes	1	9	4
662	S:S:C109	S:S:H113	2.95	Yes	Yes	1	5	6
663	S:S:C109	S:S:V177	3.42	Yes	Yes	1	5	4
664	S:S:C109	S:S:C186	7.28	Yes	No	1	5	9
665	S:S:K110	S:S:N176	5.6	No	No	1	6	4
666	S:S:A175	S:S:H113	7.32	No	Yes	0	4	6
667	S:S:C186	S:S:H113	2.95	No	Yes	1	9	6
668	S:S:H113	S:S:R188	7.9	Yes	Yes	0	6	5
669	S:S:T168	S:S:V114	9.52	Yes	No	13	6	5
670	S:S:F172	S:S:V114	11.8	No	No	13	4	5
671	S:S:L120	S:S:Y116	15.24	No	Yes	1	9	8
672	S:S:W252	S:S:Y116	3.86	Yes	Yes	1	9	8
673	S:S:E288	S:S:Y116	7.86	Yes	Yes	1	5	8
674	S:S:F292	S:S:Y116	7.22	Yes	Yes	1	7	8
675	S:S:T117	S:S:T168	7.85	No	Yes	13	7	6
676	S:S:D171	S:S:T117	13.01	No	No	13	4	7
677	S:S:L165	S:S:V118	2.98	No	No	0	3	7
678	S:S:T168	S:S:V118	3.17	Yes	No	0	6	7
679	S:S:H294	S:S:N119	3.83	Yes	No	1	9	7
680	S:S:L120	S:S:W252	4.56	No	Yes	1	9	9
681	S:S:L167	S:S:Y121	10.55	No	Yes	0	5	7
682	S:S:V206	S:S:Y121	3.79	No	Yes	0	4	7
683	S:S:G207	S:S:Y121	2.9	No	Yes	0	5	7
684	S:S:I126	S:S:S122	3.1	No	No	0	5	5
685	S:S:S122	S:S:W161	4.94	No	No	0	5	9
686	S:S:F248	S:S:S123	5.28	Yes	No	0	9	7
687	S:S:P211	S:S:V124	7.07	No	No	0	9	8
688	S:S:F248	S:S:V124	3.93	Yes	No	0	9	8
689	S:S:L210	S:S:W125	6.83	No	No	0	6	7
690	S:S:P211	S:S:W125	21.62	No	No	0	9	7
691	S:S:I126	S:S:I130	2.94	No	Yes	0	5	8
692	S:S:L127	S:S:L244	2.77	No	No	0	8	7
693	S:S:I245	S:S:L127	4.28	No	No	0	7	8
694	S:S:F248	S:S:L127	8.53	Yes	No	0	9	8
695	S:S:A128	S:S:I215	3.25	No	Yes	0	9	7
696	S:S:F129	S:S:L151	6.09	Yes	Yes	5	6	4
697	S:S:F129	S:S:V155	3.93	Yes	No	5	6	2
698	S:S:F129	S:S:V160	3.93	Yes	No	0	6	7
699	S:S:I130	S:S:T241	6.08	Yes	No	5	8	7
700	S:S:I215	S:S:S131	6.19	Yes	No	0	7	9
701	S:S:S131	S:S:Y219	5.09	No	Yes	0	9	8
702	S:S:L132	S:S:L151	2.77	No	Yes	0	8	4
703	S:S:C218	S:S:L132	4.76	No	No	0	6	8
704	S:S:D133	S:S:R148	20.25	Yes	Yes	5	5	6
705	S:S:D133	S:S:L151	2.71	Yes	Yes	5	5	4
706	S:S:L238	S:S:R134	6.07	No	No	0	5	8
707	S:S:L136	S:S:Y135	4.69	No	Yes	0	7	8
708	S:S:V139	S:S:Y135	11.36	No	Yes	20	5	8
709	S:S:H140	S:S:Y135	10.89	No	Yes	20	5	8
710	S:S:C218	S:S:Y135	2.69	No	Yes	0	6	8
711	S:S:I221	S:S:Y135	9.67	No	Yes	0	4	8
712	S:S:L136	S:S:R148	3.64	No	Yes	0	7	6
713	S:S:A137	S:S:R148	5.53	No	Yes	0	6	6
714	S:S:I138	S:S:L238	5.71	No	No	0	8	5
715	S:S:H140	S:S:V139	11.07	No	No	20	5	5
716	S:S:K225	S:S:V139	12.14	No	No	0	4	5
717	S:S:R146	S:S:R148	3.2	No	Yes	0	5	6
718	S:S:E153	S:S:K149	12.15	No	No	0	7	6
719	S:S:L150	S:S:V155	2.98	No	No	0	4	2
720	S:S:L151	S:S:V155	4.47	Yes	No	5	4	2
721	S:S:V156	S:S:Y157	5.05	No	No	5	5	7
722	S:S:G159	S:S:P163	4.06	No	No	0	3	4
723	S:S:I162	S:S:P163	3.39	No	No	0	4	4
724	S:S:I162	S:S:L166	2.85	No	No	0	4	4
725	S:S:L167	S:S:Q202	5.32	No	No	0	5	3
726	S:S:D171	S:S:T168	4.34	No	Yes	13	4	6
727	S:S:F172	S:S:T168	3.89	No	Yes	13	4	6
728	S:S:F199	S:S:P170	13	Yes	No	0	5	8
729	S:S:D171	S:S:R188	5.96	No	Yes	0	4	5
730	S:S:F174	S:S:I173	7.54	Yes	No	0	4	3
731	S:S:F174	S:S:Y190	15.47	Yes	Yes	12	4	4
732	S:S:F174	S:S:P191	5.78	Yes	No	12	4	5
733	S:S:F174	S:S:W195	6.01	Yes	Yes	12	4	5
734	S:S:F174	S:S:F199	3.22	Yes	Yes	12	4	5
735	S:S:V177	S:S:Y184	3.79	Yes	No	0	4	5
736	S:S:F189	S:S:S178	7.93	No	No	0	3	1
737	S:S:I185	S:S:R183	5.01	No	Yes	1	3	3
738	S:S:D187	S:S:F189	9.55	No	No	0	3	3
739	S:S:R188	S:S:Y190	12.35	Yes	Yes	0	5	4
740	S:S:W195	S:S:Y190	2.89	Yes	Yes	12	5	4
741	S:S:V196	S:S:Y190	5.05	No	Yes	0	4	4
742	S:S:F199	S:S:Y190	6.19	Yes	Yes	12	5	4
743	S:S:P191	S:S:W195	9.46	No	Yes	12	5	5
744	S:S:D193	S:S:N192	2.69	No	No	0	1	1
745	S:S:L194	S:S:N192	9.61	No	No	0	2	1
746	S:S:F199	S:S:W195	4.01	Yes	Yes	12	5	5
747	S:S:F199	S:S:V198	3.93	Yes	No	0	5	3
748	S:S:H203	S:S:I204	3.98	No	No	0	4	5
749	S:S:I204	S:S:I209	2.94	No	No	0	5	4
750	S:S:I209	S:S:M205	7.29	No	No	0	4	4
751	S:S:L208	S:S:Y256	19.93	No	No	0	8	8
752	S:S:F249	S:S:I215	3.77	No	Yes	0	4	7
753	S:S:T241	S:S:Y219	3.75	No	Yes	0	7	8
754	S:S:V242	S:S:Y219	7.57	No	Yes	0	4	8
755	S:S:I245	S:S:Y219	3.63	No	Yes	0	7	8
756	S:S:I221	S:S:K225	4.36	No	No	0	4	4
757	S:S:I222	S:S:L238	2.85	No	No	0	8	5
758	S:S:G231	S:S:H232	3.18	No	No	0	4	4
759	S:S:L246	S:S:V242	2.98	No	No	0	5	4
760	S:S:A247	S:S:L297	4.73	No	No	0	6	6
761	S:S:F248	S:S:W252	6.01	Yes	Yes	1	9	9
762	S:S:F248	S:S:H294	9.05	Yes	Yes	1	9	9
763	S:S:C251	S:S:F293	2.79	No	No	1	8	5
764	S:S:C251	S:S:H294	2.95	No	Yes	1	8	9
765	S:S:C251	S:S:L297	3.17	No	No	1	8	6
766	S:S:W252	S:S:Y255	5.79	Yes	Yes	0	9	7
767	S:S:A291	S:S:W252	9.08	No	Yes	0	8	9
768	S:S:F292	S:S:W252	4.01	Yes	Yes	1	7	9
769	S:S:H294	S:S:W252	12.7	Yes	Yes	1	9	9
770	S:S:L253	S:S:P254	3.28	No	No	0	5	9
771	S:S:P254	S:S:T287	3.5	No	No	0	9	6
772	S:S:I259	S:S:Y255	7.25	No	Yes	0	5	7
773	S:S:T287	S:S:Y255	4.99	No	Yes	0	6	7
774	S:S:E288	S:S:Y255	13.47	Yes	Yes	0	5	7
775	S:S:I257	S:S:I261	2.94	Yes	No	0	6	5
776	S:S:G258	S:S:I284	3.53	No	No	0	4	4
777	S:S:I259	S:S:S260	4.64	No	No	0	5	5
778	S:S:I259	S:S:S263	7.74	No	No	0	5	5
779	S:S:I261	S:S:V280	4.61	No	Yes	22	5	5
780	S:S:D262	S:S:I265	9.8	No	No	0	5	3
781	S:S:D262	S:S:V280	7.3	No	Yes	0	5	5
782	S:S:E277	S:S:I265	2.73	No	No	0	2	3
783	S:S:C274	S:S:E277	3.04	No	No	0	5	2
784	S:S:F276	S:S:V280	7.87	Yes	Yes	0	1	5
785	S:S:I286	S:S:W283	3.52	Yes	No	0	6	6
786	S:S:I286	S:S:L290	2.85	Yes	No	1	6	7
787	S:S:E288	S:S:F292	5.83	Yes	Yes	1	5	7
788	S:S:F293	S:S:L297	3.65	No	No	1	5	6
789	S:S:C295	S:S:H294	7.37	Yes	Yes	1	9	9
790	S:S:N298	S:S:P299	3.26	Yes	Yes	7	9	9
791	S:S:N298	S:S:Y302	6.98	Yes	Yes	7	9	9
792	P:P:A83	P:P:W161	2.59	No	No	0	7	9
793	P:P:F304	P:P:I300	2.51	No	No	0	6	6
794	R:R:F40	R:R:I286	2.51	No	No	0	5	6
795	R:R:F264	R:R:I270	2.51	No	Yes	0	4	5
796	S:S:K149	S:S:R146	2.48	No	No	0	6	5
797	P:P:F104	P:P:L108	2.44	Yes	No	0	1	4
798	P:P:F293	P:P:L297	2.44	No	No	0	5	6
799	R:R:F49	R:R:L50	2.44	Yes	No	0	6	5
800	R:R:F49	R:R:L91	2.44	Yes	Yes	0	6	8
801	R:R:F107	R:R:L108	2.44	No	No	0	1	5
802	S:S:F249	S:S:L208	2.44	No	No	0	4	8
803	P:P:T279	P:P:W283	2.43	No	No	0	2	6
804	R:R:L78	R:R:R70	2.43	No	Yes	0	5	6
805	S:S:I284	S:S:Y255	2.42	No	Yes	0	4	7
806	P:P:K67	P:P:Y65	2.39	No	No	0	6	6
807	R:R:L41	R:R:Y45	2.34	No	Yes	0	6	7
808	R:R:L61	R:R:Y65	2.34	No	No	0	4	5
809	P:P:H232	P:P:R235	2.26	No	No	0	4	5
810	P:P:C296	P:P:G52	1.96	Yes	No	0	7	8
811	R:R:C296	R:R:G52	1.96	No	No	0	7	8
812	S:S:C296	S:S:G52	1.96	No	No	0	7	8
813	P:P:A95	P:P:P42	1.87	No	No	0	5	7
814	P:P:A98	P:P:P42	1.87	No	No	0	4	7
815	R:R:A95	R:R:P42	1.87	No	No	0	7	5
816	R:R:A98	R:R:P42	1.87	No	No	0	5	5
817	S:S:A95	S:S:P42	1.87	No	No	0	5	7
818	R:R:G52	R:R:V88	1.84	No	No	0	8	6
819	R:R:G55	R:R:V54	1.84	No	No	0	8	4
820	R:R:G159	R:R:V158	1.84	No	No	0	3	4
821	S:S:G55	S:S:V54	1.84	No	No	0	5	3
822	P:P:G258	P:P:I284	1.76	No	Yes	0	4	4
823	S:S:G57	S:S:I60	1.76	No	Yes	0	7	6
824	S:S:G212	S:S:I215	1.76	No	Yes	0	6	7
825	S:S:G258	S:S:I257	1.76	No	Yes	0	4	6
826	R:R:G64	R:R:M63	1.75	No	Yes	0	2	6
827	S:S:G64	S:S:M63	1.75	No	Yes	0	6	4
828	P:P:G231	P:P:K230	1.74	No	No	0	4	5
829	P:P:G64	P:P:L78	1.71	No	No	0	6	9
830	R:R:G57	R:R:L85	1.71	No	No	0	3	7
831	R:R:A83	R:R:S122	1.71	No	No	0	8	7
832	R:R:A164	R:R:S122	1.71	No	No	0	7	7
833	S:S:A128	S:S:V214	1.7	No	No	0	9	6
834	S:S:I169	S:S:P170	1.69	No	No	0	3	8
835	R:R:A141	R:R:T142	1.68	No	No	0	8	5
836	P:P:C220	P:P:I221	1.64	No	No	0	3	4
837	P:P:G273	P:P:Q272	1.64	No	No	0	5	2
838	P:P:C296	P:P:I300	1.64	Yes	No	0	7	6
839	R:R:G273	R:R:Q272	1.64	No	No	0	5	2
840	S:S:L91	S:S:P92	1.64	Yes	No	0	7	7
841	S:S:G273	S:S:Q272	1.64	No	No	0	5	2
842	S:S:E277	S:S:G273	1.64	No	No	0	2	5
843	R:R:V62	S:S:S224	1.62	No	No	0	7	4
844	S:S:A180	S:S:I185	1.62	No	No	0	1	3
845	S:S:A98	S:S:K38	1.61	No	No	0	4	6
846	S:S:A137	S:S:K234	1.61	No	No	0	6	7
847	R:R:V155	R:R:V158	1.6	No	No	0	2	4
848	R:R:L61	S:S:C220	1.59	No	No	0	4	3
849	R:R:C218	R:R:L132	1.59	No	No	0	6	6
850	R:R:C251	R:R:L297	1.59	No	No	0	8	6
851	P:P:A111	P:P:L108	1.58	No	No	0	5	4
852	P:P:C274	P:P:N278	1.57	No	No	0	5	3
853	S:S:A34	S:S:N37	1.56	No	Yes	0	3	5
854	P:P:I213	P:P:S217	1.55	No	No	0	3	3
855	P:P:I259	P:P:S263	1.55	No	No	0	5	5
856	R:R:I213	R:R:S217	1.55	No	No	0	3	3
857	S:S:I213	S:S:S217	1.55	No	No	0	3	3
858	P:P:I53	P:P:V54	1.54	No	No	0	9	3
859	P:P:I261	P:P:V280	1.54	No	Yes	0	5	5
860	S:S:I53	S:S:V54	1.54	No	No	0	9	3
861	S:S:I53	S:S:V88	1.54	No	Yes	0	9	8
862	P:P:I47	P:P:T43	1.52	No	No	0	5	5
863	P:P:I47	P:P:T51	1.52	No	No	0	5	4
864	P:P:M63	P:P:V62	1.52	No	No	0	4	5
865	R:R:I89	R:R:T90	1.52	No	No	0	4	6
866	S:S:I47	S:S:T43	1.52	No	No	0	5	5
867	S:S:I47	S:S:T51	1.52	No	No	0	5	4
868	R:R:F249	R:R:G212	1.51	No	No	0	4	6
869	P:P:L58	P:P:V54	1.49	No	No	0	4	3
870	P:P:L78	P:P:V82	1.49	No	No	0	9	7
871	P:P:L165	P:P:V118	1.49	No	No	0	3	7
872	R:R:L86	R:R:V82	1.49	No	No	0	7	5
873	R:R:L165	R:R:V118	1.49	No	No	0	3	5
874	S:S:L58	S:S:V54	1.49	No	No	0	4	3
875	S:S:L58	S:S:V62	1.49	No	No	0	4	5
876	P:P:I204	P:P:I209	1.47	No	No	0	5	4
877	P:P:I209	P:P:I213	1.47	No	No	0	4	3
878	R:R:I209	R:R:I213	1.47	No	No	0	4	3
879	R:R:C251	R:R:H294	1.47	No	Yes	0	8	9
880	R:R:I257	R:R:I261	1.47	No	No	0	6	5
881	S:S:I209	S:S:I213	1.47	No	No	0	4	3
882	S:S:L301	S:S:T240	1.47	No	No	0	7	7
883	P:P:D193	P:P:V196	1.46	No	No	0	1	4
884	R:R:I286	R:R:K282	1.45	No	No	0	6	2
885	S:S:I243	S:S:K239	1.45	No	No	0	5	6
886	R:R:P147	R:R:R146	1.44	No	No	0	4	5
887	S:S:P147	S:S:R146	1.44	No	No	0	4	5
888	S:S:Q200	S:S:S263	1.44	No	No	0	5	5
889	P:P:I138	P:P:L226	1.43	No	No	19	8	8
890	P:P:I162	P:P:L166	1.43	No	No	0	4	4
891	P:P:I169	P:P:L166	1.43	No	No	0	3	4
892	P:P:I222	P:P:L226	1.43	No	No	19	8	8
893	P:P:I269	P:P:L267	1.43	No	No	0	1	1
894	R:R:I138	R:R:L226	1.43	No	Yes	0	8	8
895	R:R:I162	R:R:L166	1.43	No	No	0	4	4
896	R:R:I169	R:R:L166	1.43	No	No	0	3	4
897	R:R:I222	R:R:L226	1.43	No	Yes	0	8	8
898	R:R:I223	R:R:L226	1.43	No	Yes	0	4	8
899	S:S:Q66	S:S:V62	1.43	No	No	0	6	5
900	S:S:I89	S:S:L85	1.43	No	No	0	9	6
901	S:S:I138	S:S:L226	1.43	No	No	0	8	8
902	S:S:I162	S:S:L165	1.43	No	No	0	4	3
903	S:S:I222	S:S:L226	1.43	No	No	0	8	8
904	S:S:I243	S:S:L301	1.43	No	No	0	5	7
905	S:S:I265	S:S:L266	1.43	No	No	0	3	3
906	S:S:G105	S:S:W102	1.41	No	Yes	0	5	8
907	S:S:K154	S:S:L150	1.41	No	No	0	3	4
908	S:S:K38	S:S:N37	1.4	No	Yes	0	6	5
909	S:S:A111	S:S:F107	1.39	No	No	0	5	7
910	P:P:A180	P:P:R183	1.38	No	Yes	0	1	3
911	P:P:L266	S:S:L194	1.38	No	No	0	3	2
912	R:R:A237	R:R:R134	1.38	No	Yes	0	7	9
913	P:P:E277	P:P:I265	1.37	No	No	0	2	3
914	S:S:K236	S:S:Q233	1.36	No	No	0	8	5
915	R:R:E153	R:R:K154	1.35	No	No	0	7	3
916	S:S:A164	S:S:Y121	1.33	No	Yes	0	7	7
917	S:S:H281	S:S:I284	1.33	No	No	0	4	4
918	S:S:F264	S:S:S263	1.32	No	No	0	4	5
919	P:P:H232	P:P:K236	1.31	No	No	0	4	8
920	R:R:D182	S:S:Q272	1.31	No	No	0	6	2
921	R:R:F264	R:R:I269	1.26	No	No	0	4	1
922	S:S:F36	S:S:I39	1.26	No	No	0	5	5
923	P:P:K38	P:P:R183	1.24	No	Yes	0	6	3
924	P:P:K149	P:P:R146	1.24	No	No	0	6	5
925	S:S:H232	S:S:Q233	1.24	No	No	0	4	5
926	R:R:F304	R:R:L305	1.22	No	No	0	6	6
927	S:S:F107	S:S:L108	1.22	No	No	0	7	4
928	P:P:L78	P:P:R70	1.21	No	No	0	9	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	11.6414	7	2	0
2	M:M:?1	8.6475	8	1	0
3	P:P:Y45	4.88333	6	6	7
4	P:P:N56	4.99	5	0	8
5	P:P:V59	4.59	4	3	7
6	P:P:Y76	5.868	5	8	9
7	P:P:R77	12.61	4	3	9
8	P:P:H79	6.556	5	15	5
9	P:P:L80	3.318	5	3	8
10	P:P:S81	5.775	4	3	9
11	P:P:D84	6.0925	4	0	7
12	P:P:L85	3.1675	4	0	6
13	P:P:F87	8.105	6	6	6
14	P:P:V88	3.72	4	0	8
15	P:P:L91	3.99	4	6	7
16	P:P:W94	7.60286	7	6	5
17	P:P:W102	8.75286	7	9	8
18	P:P:F104	10.725	4	0	1
19	P:P:C109	4.3925	4	9	5
20	P:P:H113	4.3475	4	9	6
21	P:P:Y116	7.94833	6	6	8
22	P:P:Y121	5.965	4	18	7
23	P:P:I126	2.885	4	0	5
24	P:P:L127	5.6575	4	3	8
25	P:P:F129	5.48	4	8	6
26	P:P:S131	4.1375	4	3	9
27	P:P:D133	9.08	4	8	5
28	P:P:R134	4.86667	6	8	8
29	P:P:Y135	4.645	4	0	8
30	P:P:R148	7.096	5	8	6
31	P:P:T168	6.505	4	17	6
32	P:P:F174	6.334	5	11	4
33	P:P:V177	3.4625	4	9	4
34	P:P:R183	4.75	5	6	3
35	P:P:R188	8.31	4	0	5
36	P:P:Y190	7.608	5	11	4
37	P:P:W195	7.11	5	11	5
38	P:P:F199	5.822	5	11	5
39	P:P:Y219	4.345	4	0	8
40	P:P:F248	7.74167	6	3	9
41	P:P:W252	10.256	5	3	9
42	P:P:Y255	8.9275	4	0	7
43	P:P:D262	7.0325	4	21	5
44	P:P:V280	2.5375	4	21	5
45	P:P:I284	3.3425	4	21	4
46	P:P:I286	5.62	4	14	6
47	P:P:E288	9.1825	4	6	5
48	P:P:F292	7.02	5	6	7
49	P:P:H294	8.088	5	3	9
50	P:P:C295	5.75	4	0	9
51	P:P:C296	3.9125	4	0	7
52	P:P:N298	6.16333	6	3	9
53	P:P:P299	4.75	4	3	9
54	P:P:Y302	11.354	5	3	9
55	R:R:Y45	4.36833	6	2	7
56	R:R:F49	4.28	4	0	6
57	R:R:N56	6.71	4	0	9
58	R:R:M63	6.418	5	10	6
59	R:R:R70	6.7625	4	10	6
60	R:R:D74	5.49	5	10	8
61	R:R:Y76	5.05667	6	4	7
62	R:R:H79	8.04	4	4	9
63	R:R:D84	6.3825	4	0	9
64	R:R:F87	8.00833	6	2	7
65	R:R:L91	3.566	5	0	8
66	R:R:W94	8.36	6	2	7
67	R:R:W102	8.06714	7	2	9
68	R:R:H113	5.992	5	2	6
69	R:R:Y116	7.30667	6	2	6
70	R:R:Y121	5.474	5	2	7
71	R:R:V124	5.095	4	2	7
72	R:R:W125	8.86	4	2	5
73	R:R:F129	6.274	5	4	5
74	R:R:D133	8.54	4	4	8
75	R:R:R134	3.65	6	4	9
76	R:R:Y135	6.9125	4	24	8
77	R:R:V139	6.7575	4	24	7
78	R:R:R148	7.74	6	4	6
79	R:R:V156	5.104	5	4	5
80	R:R:T168	6.1125	4	23	6
81	R:R:F174	7.895	4	2	4
82	R:R:V177	5.425	4	2	4
83	R:R:R183	6.565	4	16	3
84	R:R:Y190	9.348	5	2	4
85	R:R:W195	8.292	5	2	5
86	R:R:F199	6.86	4	2	5
87	R:R:Q200	7.21	4	0	5
88	R:R:H203	9.4775	4	2	4
89	R:R:I204	3.455	4	0	5
90	R:R:Y219	4.065	4	0	8
91	R:R:L226	3.1975	4	0	8
92	R:R:L244	2.765	4	0	7
93	R:R:F248	7.628	5	2	9
94	R:R:W252	7.67143	7	2	9
95	R:R:Y255	7.73667	6	2	7
96	R:R:Y256	7.638	5	2	8
97	R:R:I259	6.9625	4	0	5
98	R:R:L266	3.525	4	0	3
99	R:R:I270	3.89	4	0	5
100	R:R:E288	10.16	5	2	5
101	R:R:F292	7.4	6	2	7
102	R:R:H294	6.16833	6	2	9
103	R:R:C295	5.3625	4	0	9
104	R:R:N298	5.9675	4	10	9
105	R:R:P299	5.5625	4	0	9
106	R:R:Y302	10.956	5	10	9
107	S:S:N37	3.36143	7	1	5
108	S:S:F40	7.9875	4	1	4
109	S:S:Y45	5.39667	6	1	7
110	S:S:N56	4.8175	4	0	8
111	S:S:V59	4.4025	4	7	7
112	S:S:I60	3.41	4	0	6
113	S:S:M63	4.51429	7	7	4
114	S:S:T73	4.0175	4	5	7
115	S:S:Y76	6.17667	6	5	9
116	S:S:R77	13.1575	4	7	9
117	S:S:S81	5.03	4	7	9
118	S:S:D84	6.076	5	1	7
119	S:S:F87	6.91714	7	1	6
120	S:S:V88	3.365	4	0	8
121	S:S:L91	3.80167	6	1	7
122	S:S:W94	7.64429	7	1	5
123	S:S:W102	7.72	6	1	8
124	S:S:C109	4.3925	4	1	5
125	S:S:H113	5.28	4	1	6
126	S:S:Y116	8.07286	7	1	8
127	S:S:Y121	4.6425	4	0	7
128	S:S:F129	6.0675	4	5	6
129	S:S:I130	4.905	4	5	8
130	S:S:D133	10.1775	4	5	5
131	S:S:Y135	7.86	5	20	8
132	S:S:R148	8.262	5	5	6
133	S:S:L151	3.912	5	5	4
134	S:S:T168	5.754	5	13	6
135	S:S:F174	7.604	5	12	4
136	S:S:V177	4.875	4	1	4
137	S:S:R183	7.445	4	1	3
138	S:S:R188	7.47	4	0	5
139	S:S:Y190	8.39	5	12	4
140	S:S:W195	6.98	5	12	5
141	S:S:F199	6.07	5	12	5
142	S:S:I215	3.7425	4	0	7
143	S:S:Y219	5.01	4	0	8
144	S:S:F248	6.56	5	1	9
145	S:S:W252	6.57286	7	1	9
146	S:S:Y255	6.784	5	0	7
147	S:S:I257	3.4825	4	0	6
148	S:S:F276	8.165	4	0	1
149	S:S:V280	6.0975	4	22	5
150	S:S:I286	4.225	4	1	6
151	S:S:E288	9.344	5	1	5
152	S:S:F292	7.02333	6	1	7
153	S:S:H294	7.24333	6	1	9
154	S:S:C295	5.73	4	1	9
155	S:S:N298	5.62	6	7	9
156	S:S:P299	4.3425	4	7	9
157	S:S:Y302	12.0975	4	7	9
158	U:U:?1	10.5888	8	6	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W94	10.8016	17.21	Yes	Yes	2	0	7
2	R:R:W94	R:R:Y45	29.8181	8.68	Yes	Yes	2	7	7
3	R:R:A289	R:R:Y45	97.8776	2.67	No	Yes	0	4	7
4	R:R:A289	R:R:I44	97.9682	4.87	No	No	0	4	5
5	R:R:F40	R:R:I44	98.0586	7.54	No	No	0	5	5
6	R:R:F36	R:R:F40	98.5049	5.36	No	No	0	4	5
7	R:R:F36	S:S:W283	98.5942	10.02	No	No	0	4	6
8	S:S:I286	S:S:W283	98.6834	3.52	Yes	No	0	6	6
9	S:S:I286	S:S:N37	98.9207	4.25	Yes	Yes	1	6	5
10	S:S:L41	S:S:N37	99.7674	4.12	No	Yes	1	5	5
11	S:S:L41	S:S:Y45	100	8.21	No	Yes	1	5	7
12	S:S:W94	S:S:Y45	52.5238	8.68	Yes	Yes	1	5	7
13	M:M:?1	S:S:W94	49.7098	12.05	Yes	Yes	1	0	5
14	S:S:F292	S:S:Y45	27.115	4.13	Yes	Yes	1	7	7
15	M:M:?1	S:S:R188	70.5666	3.67	Yes	Yes	0	0	5
16	S:S:R188	S:S:Y190	70.5614	12.35	Yes	Yes	0	5	4
17	S:S:F199	S:S:Y190	69.2119	6.19	Yes	Yes	12	5	4
18	S:S:F199	S:S:V198	69.4876	3.93	Yes	No	0	5	3
19	P:P:F201	S:S:V198	69.4145	2.62	No	No	0	4	3
20	P:P:F201	S:S:F201	68.898	6.43	No	No	0	4	4
21	P:P:Q202	S:S:F201	68.7489	8.2	No	No	0	3	4
22	P:P:F199	P:P:Q202	68.674	3.51	Yes	No	0	5	3
23	P:P:F199	P:P:Y190	66.5359	6.19	Yes	Yes	11	5	4
24	P:P:R188	P:P:Y190	66.9058	14.4	Yes	Yes	0	5	4
25	P:P:R188	U:U:?1	62.655	3.67	Yes	Yes	0	5	0
26	P:P:W94	U:U:?1	32.8277	20.66	Yes	Yes	6	5	0
27	P:P:L91	P:P:W94	12.8815	3.42	Yes	Yes	6	7	5
28	P:P:Y116	U:U:?1	18.5304	7.97	Yes	Yes	6	8	0
29	P:P:L91	P:P:V88	13.2489	2.98	Yes	Yes	0	7	8
30	P:P:N56	P:P:V88	11.6004	2.96	Yes	Yes	0	8	8
31	P:P:F87	P:P:W94	17.5028	4.01	Yes	Yes	6	6	5
32	P:P:F87	P:P:N119	17.5599	16.92	Yes	No	0	6	7
33	P:P:D84	P:P:N119	16.6635	6.73	Yes	No	0	7	7
34	P:P:F87	P:P:Y116	17.2823	8.25	Yes	Yes	6	6	8
35	P:P:C295	P:P:F87	17.6217	2.79	Yes	Yes	0	9	6
36	P:P:C295	P:P:D84	16.846	10.89	Yes	Yes	0	9	7
37	P:P:D84	P:P:L80	32.9883	2.71	Yes	Yes	0	7	8
38	P:P:L80	P:P:N298	10.0998	5.49	Yes	Yes	3	8	9
39	P:P:I126	P:P:L80	17.0745	2.85	Yes	Yes	0	5	8
40	P:P:I126	P:P:I130	11.1004	2.94	Yes	No	0	5	8
41	P:P:R77	P:P:T240	11.6346	3.88	Yes	No	0	9	7
42	S:S:L91	S:S:Y45	20.8202	4.69	Yes	Yes	1	7	7
43	S:S:F87	S:S:L91	13.1828	6.09	Yes	Yes	1	6	7
44	S:S:F87	S:S:N119	30.144	8.46	Yes	No	1	6	7
45	S:S:D84	S:S:N119	29.822	6.73	Yes	No	1	7	7
46	S:S:D84	S:S:L80	56.9321	2.71	Yes	No	0	7	8
47	S:S:I126	S:S:L80	41.8587	7.14	No	No	0	5	8
48	S:S:I126	S:S:I130	37.3034	2.94	No	Yes	0	5	8
49	S:S:I130	S:S:Y76	30.6048	6.04	Yes	Yes	5	8	9
50	S:S:D133	S:S:Y76	13.0141	8.05	Yes	Yes	5	5	9
51	S:S:D133	S:S:R148	11.488	20.25	Yes	Yes	5	5	6
52	S:S:F87	S:S:W94	24.5271	5.01	Yes	Yes	1	6	5
53	S:S:F292	S:S:F87	13.1412	13.93	Yes	Yes	1	7	6
54	S:S:C295	S:S:F87	30.1577	2.79	Yes	Yes	1	9	6
55	S:S:C295	S:S:D84	36.1079	9.34	Yes	Yes	1	9	7
56	S:S:F292	S:S:W252	11.9354	4.01	Yes	Yes	1	7	9
57	S:S:H294	S:S:W252	12.7238	12.7	Yes	Yes	1	9	9
58	S:S:D84	S:S:H294	12.2252	7.56	Yes	Yes	1	7	9
59	P:P:L305	P:P:T240	10.1808	7.37	No	No	0	6	7
60	R:R:L91	R:R:Y45	19.7909	4.69	Yes	Yes	0	8	7
61	R:R:F87	R:R:W94	13.5001	5.01	Yes	Yes	2	7	7
62	R:R:F87	R:R:L91	12.5658	4.87	Yes	Yes	0	7	8
63	R:R:C295	R:R:F87	19.4289	2.79	Yes	Yes	0	9	7
64	R:R:F87	R:R:N119	19.372	12.08	Yes	No	0	7	8
65	R:R:D84	R:R:N119	19.0902	5.39	Yes	No	0	9	8
66	R:R:D84	R:R:N56	18.7257	6.73	Yes	Yes	0	9	9
67	R:R:C295	R:R:D84	25.0712	9.34	Yes	Yes	0	9	9
68	R:R:D84	R:R:L80	24.6699	4.07	Yes	No	0	9	9
69	R:R:F292	R:R:W252	28.4991	4.01	Yes	Yes	2	7	9
70	R:R:F248	R:R:W252	18.4346	10.02	Yes	Yes	2	9	9
71	R:R:F248	R:R:L127	17.038	8.53	Yes	No	0	9	8
72	R:R:E288	R:R:Y255	15.3619	13.47	Yes	Yes	2	5	7
73	R:R:I126	R:R:L80	23.236	5.71	No	No	0	7	9
74	R:R:I126	R:R:V160	12.202	3.07	No	No	0	7	7
75	R:R:I245	R:R:L127	11.6499	2.85	No	No	0	7	8
76	R:R:I259	R:R:Y255	18.0368	10.88	Yes	Yes	0	5	7
77	R:R:D262	R:R:L266	13.2884	2.71	No	Yes	0	5	3
78	R:R:I265	R:R:L266	10.4455	2.85	No	Yes	0	3	3
79	S:S:D84	S:S:N56	20.5063	4.04	Yes	Yes	0	7	8
80	S:S:M63	S:S:V59	16.3678	3.04	Yes	Yes	7	4	7
81	S:S:L80	S:S:N298	14.5309	5.49	No	Yes	0	8	9
82	R:R:F292	R:R:Y45	47.9568	5.16	Yes	Yes	2	7	7
83	R:R:F292	R:R:F87	12.1565	16.08	Yes	Yes	2	7	7
84	M:M:?1	S:S:Y116	20.33	4.43	Yes	Yes	1	0	8
85	S:S:F87	S:S:Y116	11.5831	8.25	Yes	Yes	1	6	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
P:P:L91	P:P:Y45	4.69	6	Yes	Yes	7	7	2	2
P:P:W94	P:P:Y45	6.75	6	Yes	Yes	5	7	1	2
P:P:F292	P:P:Y45	5.16	6	Yes	Yes	7	7	2	2
P:P:F87	P:P:L91	4.87	6	Yes	Yes	6	7	2	2
P:P:F87	P:P:W94	4.01	6	Yes	Yes	6	5	2	1
P:P:F87	P:P:Y116	8.25	6	Yes	Yes	6	8	2	1
P:P:F292	P:P:F87	11.79	6	Yes	Yes	7	6	2	2
P:P:T90	P:P:W94	3.64	0	No	Yes	6	5	2	1
P:P:L91	P:P:W94	3.42	6	Yes	Yes	7	5	2	1
P:P:W94	P:P:Y116	7.72	6	Yes	Yes	5	8	1	1
P:P:F292	P:P:W94	7.02	6	Yes	Yes	7	5	2	1
P:P:W94	U:U:?1	20.66	6	Yes	Yes	5	0	1	0
P:P:D97	P:P:W102	6.7	0	No	Yes	5	8	1	2
P:P:D97	U:U:?1	25.64	0	No	Yes	5	0	1	0
P:P:N101	P:P:R183	8.44	0	No	Yes	7	3	2	1
P:P:H113	P:P:R188	5.64	9	Yes	Yes	6	5	2	1
P:P:L120	P:P:Y116	12.89	0	No	Yes	9	8	2	1
P:P:E288	P:P:Y116	6.73	6	Yes	Yes	5	8	1	1
P:P:F292	P:P:Y116	4.13	6	Yes	Yes	7	8	2	1
P:P:Y116	U:U:?1	7.97	6	Yes	Yes	8	0	1	0
P:P:D171	P:P:R188	9.53	0	No	Yes	4	5	2	1
P:P:I185	P:P:R183	6.26	6	No	Yes	3	3	1	1
P:P:R183	U:U:?1	6.43	6	Yes	Yes	3	0	1	0
P:P:D187	P:P:I185	4.2	6	No	No	3	3	1	1
P:P:I185	U:U:?1	3.24	6	No	Yes	3	0	1	0
P:P:D187	P:P:F189	13.14	6	No	No	3	3	1	2
P:P:D187	U:U:?1	3.08	6	No	Yes	3	0	1	0
P:P:R188	P:P:Y190	14.4	0	Yes	Yes	5	4	1	2
P:P:R188	U:U:?1	3.67	0	Yes	Yes	5	0	1	0
P:P:E288	P:P:Y255	8.98	6	Yes	Yes	5	7	1	2
P:P:E288	P:P:F292	7	6	Yes	Yes	5	7	1	2
P:P:E288	U:U:?1	14.02	6	Yes	Yes	5	0	1	0
P:P:A180	P:P:R183	1.38	0	No	Yes	1	3	2	1
P:P:K38	P:P:R183	1.24	0	No	Yes	6	3	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
M:M:?1	S:S:W94	12.05	1	Yes	Yes	0	5	0	1
M:M:?1	S:S:D97	20.51	1	Yes	No	0	5	0	1
M:M:?1	S:S:Y116	4.43	1	Yes	Yes	0	8	0	1
M:M:?1	S:S:R183	9.18	1	Yes	Yes	0	3	0	1
M:M:?1	S:S:I185	3.24	1	Yes	No	0	3	0	1
M:M:?1	S:S:D187	3.08	1	Yes	No	0	3	0	1
M:M:?1	S:S:R188	3.67	1	Yes	Yes	0	5	0	1
M:M:?1	S:S:E288	13.02	1	Yes	Yes	0	5	0	1
S:S:L91	S:S:Y45	4.69	1	Yes	Yes	7	7	2	2
S:S:W94	S:S:Y45	8.68	1	Yes	Yes	5	7	1	2
S:S:F292	S:S:Y45	4.13	1	Yes	Yes	7	7	2	2
S:S:F87	S:S:L91	6.09	1	Yes	Yes	6	7	2	2
S:S:F87	S:S:W94	5.01	1	Yes	Yes	6	5	2	1
S:S:F87	S:S:Y116	8.25	1	Yes	Yes	6	8	2	1
S:S:F292	S:S:F87	13.93	1	Yes	Yes	7	6	2	2
S:S:L91	S:S:W94	4.56	1	Yes	Yes	7	5	2	1
S:S:W94	S:S:Y116	9.65	1	Yes	Yes	5	8	1	1
S:S:E288	S:S:W94	6.54	1	Yes	Yes	5	5	1	1
S:S:F292	S:S:W94	7.02	1	Yes	Yes	7	5	2	1
S:S:D97	S:S:W102	4.47	1	No	Yes	5	8	1	2
S:S:D97	S:S:R183	7.15	1	No	Yes	5	3	1	1
S:S:N101	S:S:R183	8.44	0	No	Yes	7	3	2	1
S:S:H113	S:S:R188	7.9	1	Yes	Yes	6	5	2	1
S:S:L120	S:S:Y116	15.24	1	No	Yes	9	8	2	1
S:S:W252	S:S:Y116	3.86	1	Yes	Yes	9	8	2	1
S:S:E288	S:S:Y116	7.86	1	Yes	Yes	5	8	1	1
S:S:F292	S:S:Y116	7.22	1	Yes	Yes	7	8	2	1
S:S:L120	S:S:W252	4.56	1	No	Yes	9	9	2	2
S:S:D171	S:S:R188	5.96	13	No	Yes	4	5	2	1
S:S:I185	S:S:R183	5.01	1	No	Yes	3	3	1	1
S:S:D187	S:S:F189	9.55	0	No	No	3	3	1	2
S:S:R188	S:S:Y190	12.35	0	Yes	Yes	5	4	1	2
S:S:W252	S:S:Y255	5.79	1	Yes	Yes	9	7	2	2
S:S:F292	S:S:W252	4.01	1	Yes	Yes	7	9	2	2
S:S:E288	S:S:Y255	13.47	1	Yes	Yes	5	7	1	2
S:S:E288	S:S:F292	5.83	1	Yes	Yes	5	7	1	2
S:S:A180	S:S:I185	1.62	0	No	No	1	3	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:W94	17.21	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:D97	22.56	2	Yes	No	0	5	0	1
L:L:?1	R:R:W102	5.16	2	Yes	Yes	0	9	0	1
L:L:?1	R:R:H113	5.83	2	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y116	10.63	2	Yes	Yes	0	6	0	1
L:L:?1	R:R:D187	3.08	2	Yes	No	0	3	0	1
L:L:?1	R:R:E288	17.02	2	Yes	Yes	0	5	0	1
R:R:W94	R:R:Y45	8.68	2	Yes	Yes	7	7	1	2
R:R:F292	R:R:Y45	5.16	2	Yes	Yes	7	7	2	2
R:R:F87	R:R:W94	5.01	2	Yes	Yes	7	7	2	1
R:R:F87	R:R:Y116	7.22	2	Yes	Yes	7	6	2	1
R:R:F292	R:R:F87	16.08	2	Yes	Yes	7	7	2	2
R:R:W94	R:R:Y116	5.79	2	Yes	Yes	7	6	1	1
R:R:E288	R:R:W94	5.45	2	Yes	Yes	5	7	1	1
R:R:F292	R:R:W94	8.02	2	Yes	Yes	7	7	2	1
R:R:D97	R:R:W102	6.7	2	No	Yes	5	9	1	1
R:R:F104	R:R:W102	11.02	0	No	Yes	7	9	2	1
R:R:G105	R:R:W102	2.81	0	No	Yes	8	9	2	1
R:R:C109	R:R:W102	6.53	2	No	Yes	9	9	2	1
R:R:V177	R:R:W102	8.58	2	Yes	Yes	4	9	2	1
R:R:C186	R:R:W102	15.67	2	No	Yes	9	9	2	1
R:R:C109	R:R:V177	3.42	2	No	Yes	9	4	2	2
R:R:C109	R:R:C186	7.28	2	No	No	9	9	2	2
R:R:D171	R:R:H113	6.3	2	No	Yes	4	6	2	1
R:R:A175	R:R:H113	5.85	0	No	Yes	4	6	2	1
R:R:C186	R:R:H113	2.95	2	No	Yes	9	6	2	1
R:R:H113	R:R:R188	9.03	2	Yes	No	6	5	1	2
R:R:L120	R:R:Y116	8.21	0	No	Yes	7	6	2	1
R:R:E288	R:R:Y116	7.86	2	Yes	Yes	5	6	1	1
R:R:F292	R:R:Y116	4.13	2	Yes	Yes	7	6	2	1
R:R:D171	R:R:R188	10.72	2	No	No	4	5	2	2
R:R:D187	R:R:F189	10.75	0	No	No	3	3	1	2
R:R:E288	R:R:Y255	13.47	2	Yes	Yes	5	7	1	2
R:R:E288	R:R:F292	7	2	Yes	Yes	5	7	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	3OE8_poly
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.62
Number of Linked Nodes	737
Number of Links	928
Number of Hubs	158
Number of Links mediated by Hubs	555
Number of Communities	24
Number of Nodes involved in Communities	208
Number of Links involved in Communities	312

Path Summary
Number Of Nodes in MetaPath	86
Number Of Links MetaPath	85
Number of Shortest Paths	1847941
Length Of Smallest Path	3
Average Path Length	26.5028
Length of Longest Path	53
Minimum Path Strength	1.3
Average Path Strength	6.23812
Maximum Path Strength	23.15
Minimum Path Correlation	0.7
Average Path Correlation	0.986782
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.5641
Average % Of Corr. Nodes	43.9372
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	58.4275
Maximum Path Hubs %	100

Details about the values in these tables can be found in the corresponding documentation page .


Code	ITD
PDB Residues	L:L:?1 M:M:?1 U:U:?1
Environment Details	Open EMBL-EBI Page
Code	ITD
Name	(6,6-dimethyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-3-yl)methyl N,N'-dicyclohexylimidothiocarbamate
Synonyms
Identifier
Formula	C21 H34 N4 S2
Molecular Weight	406.651
SMILES
PubChem	25147749
Formal Charge	0
Total Atoms	61
Total Chiral Atoms	0
Total Bonds	64
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P61073
Sequence	>3OE8_poly_Chain_R P C N F N K I F L P T I Y S I I F L T G I V G N G L V I L V M G Y Q K K L R S M T D K Y R L H L S V A D L L F V I T L P F W A V D A V A N W Y F G N F L C K A V H V I Y T V N L Y S S V W I L A F I S L D R Y L A I V H A T N S Q R P R K L L A E K V V Y V G V W I P A L L L T I P D F I F A N V S E A D D R Y I C D R F Y P N D L W V V V F Q F Q H I M V G L I L P G I V I L S C Y C I I I S K L S H S H Q K R K A L K T T V I L I L A F F A C W L P Y Y I G I S I D S F I L L E I I K Q G C E F E N T V H K W I S I T E A L A F F H C C L N P I L Y A F L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YU7	A	Protein	Chemokine	CXCR4	Homo sapiens	-	-	-	3.01	2025-03-05	10.1016/j.celrep.2025.115255
	8YU7 (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	-	-		3.01	2025-03-05	10.1016/j.celrep.2025.115255
	8K3Z	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-	Gi1/β1/γ1	2.81	2024-07-17	To be published
	8K3Z (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	-		2.81	2024-07-17	To be published
	8U4T	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	-	3.38	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8U4T (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-		3.38	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8U4S	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-	-	3.35	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8U4S (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	-		3.35	2024-03-13	doi.org/10.1038/s41594-024-01397-1
	8U4R	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	Cholesterol	-	3.1	2024-03-13	10.1101/2024.02.09.579708
	8U4Q	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	Cholesterol	Gi1/β1/γ2	3.36	2024-03-13	10.1101/2024.02.09.579708
	8U4Q (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	Cholesterol		3.36	2024-03-13	10.1101/2024.02.09.579708
	8U4P	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	Cholesterol	Gi1/β1/γ2	3.15	2024-03-13	10.1101/2024.02.09.579708
	8U4P (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	Cholesterol		3.15	2024-03-13	10.1101/2024.02.09.579708
	8U4O	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	Cholesterol	Gi1/β1/γ2	3.29	2024-03-13	10.1101/2024.02.09.579708
	8U4O (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	Cholesterol		3.29	2024-03-13	10.1101/2024.02.09.579708
	8U4N	A	Protein	Chemokine	CXCR4	Homo sapiens	-	Cholesterol	Gi1/β1/γ2	2.72	2024-03-13	10.1101/2024.02.09.579708
	8U4N (No Gprot)	A	Protein	Chemokine	CXCR4	Homo sapiens	-	Cholesterol		2.72	2024-03-13	10.1101/2024.02.09.579708
	8ZPN	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	Cholesterol	-	3.31	2025-02-26	To be published
	8ZPM	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD070	Cholesterol	-	3.2	2025-02-26	To be published
	8ZPL	A	Protein	Chemokine	CXCR4	Homo sapiens	HF51116	Cholesterol	-	3.01	2025-02-26	To be published
	4RWS	A	Protein	Chemokine	CXCR4	Homo sapiens	vMIP-II	-	-	3.1	2015-02-11	10.1126/science.1261064
	3OE9	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.1	2010-10-27	10.1126/science.1194396
	3OE9 (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-		3.1	2010-10-27	10.1126/science.1194396
	3OE8	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.1	2010-10-27	10.1126/science.1194396
	3OE8 (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-		3.1	2010-10-27	10.1126/science.1194396
	3OE6	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	3.2	2010-10-27	10.1126/science.1194396
	3OE0	A	Protein	Chemokine	CXCR4	Homo sapiens	CVX15	-	-	2.9	2010-10-27	10.1126/science.1194396
	3ODU	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-	-	2.5	2010-10-27	10.1126/science.1194396
	3ODU (Multimeric)	A	Protein	Chemokine	CXCR4	Homo sapiens	IT1t	-		2.5	2010-10-27	10.1126/science.1194396

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 3OE8_poly.zip

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