psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C274	R:R:C28	5.46	No	No	0	5	9
2	R:R:C28	R:R:E277	9.12	No	No	0	9	2
3	R:R:K38	R:R:N35	12.59	No	No	0	4	3
4	R:R:F36	R:R:N37	8.46	No	Yes	0	4	3
5	R:R:F40	R:R:N37	7.25	No	Yes	0	5	3
6	R:R:K282	R:R:N37	13.99	No	Yes	7	2	3
7	R:R:I286	R:R:N37	4.25	Yes	Yes	7	6	3
8	R:R:K38	R:R:L41	4.23	No	No	0	4	6
9	R:R:F40	R:R:I44	3.77	No	No	0	5	5
10	R:R:L41	R:R:Y45	8.21	No	Yes	0	6	7
11	R:R:A98	R:R:P42	3.74	No	No	0	5	5
12	R:R:P42	R:R:V99	3.53	No	No	0	5	4
13	R:R:L91	R:R:Y45	4.69	No	Yes	0	8	7
14	R:R:W94	R:R:Y45	14.47	Yes	Yes	3	7	7
15	R:R:F292	R:R:Y45	4.13	Yes	Yes	3	7	7
16	R:R:F293	R:R:I48	5.02	No	No	0	5	7
17	R:R:F49	R:R:P92	5.78	No	No	0	6	9
18	R:R:C296	R:R:T51	6.76	No	No	0	7	5
19	R:R:G52	R:R:V88	3.68	No	No	0	8	6
20	R:R:G55	R:R:P299	4.06	No	Yes	0	8	9
21	R:R:N56	R:R:S81	8.94	No	No	0	9	9
22	R:R:D84	R:R:N56	6.73	Yes	No	0	9	9
23	R:R:N56	R:R:P299	11.4	No	Yes	0	9	9
24	R:R:S81	R:R:V59	4.85	No	No	0	9	8
25	R:R:P299	R:R:V59	3.53	Yes	No	0	9	8
26	R:R:M63	R:R:Y302	4.79	No	No	0	6	9
27	R:R:D74	R:R:S71	4.42	No	No	0	8	7
28	R:R:D133	R:R:M72	4.16	Yes	No	5	8	6
29	R:R:M72	R:R:R148	9.93	No	Yes	5	6	6
30	R:R:K149	R:R:M72	5.76	No	No	0	6	6
31	R:R:R134	R:R:T73	5.17	Yes	No	0	9	7
32	R:R:E153	R:R:K75	4.05	No	No	0	7	6
33	R:R:F129	R:R:Y76	6.19	Yes	Yes	5	5	7
34	R:R:I130	R:R:Y76	4.84	No	Yes	0	8	7
35	R:R:D133	R:R:Y76	5.75	Yes	Yes	5	8	7
36	R:R:L151	R:R:Y76	4.69	No	Yes	5	4	7
37	R:R:A152	R:R:Y76	4	No	Yes	0	3	7
38	R:R:N298	R:R:R77	12.05	No	No	0	9	8
39	R:R:R77	R:R:Y302	22.64	No	No	0	8	9
40	R:R:H79	R:R:V156	8.3	No	No	0	9	5
41	R:R:H79	R:R:Y157	6.53	No	No	0	9	7
42	R:R:H79	R:R:W161	9.52	No	No	0	9	9
43	R:R:D84	R:R:L80	5.43	Yes	No	0	9	9
44	R:R:L80	R:R:N298	10.98	No	No	0	9	9
45	R:R:D84	R:R:N119	6.73	Yes	No	0	9	8
46	R:R:C295	R:R:D84	10.89	No	Yes	0	9	9
47	R:R:I115	R:R:L86	9.99	No	No	0	5	7
48	R:R:F87	R:R:Y116	8.25	No	Yes	3	7	6
49	R:R:F87	R:R:N119	15.71	No	No	0	7	8
50	R:R:F292	R:R:F87	9.65	Yes	No	3	7	7
51	R:R:F93	R:R:T90	3.89	Yes	No	4	6	6
52	R:R:T90	R:R:V112	7.93	No	No	4	6	5
53	R:R:F104	R:R:F93	18.22	Yes	Yes	4	7	6
54	R:R:F93	R:R:L108	3.65	Yes	No	4	6	5
55	R:R:F93	R:R:V112	5.24	Yes	No	4	6	5
56	R:R:W94	R:R:Y116	8.68	Yes	Yes	3	7	6
57	R:R:E288	R:R:W94	6.54	Yes	Yes	3	5	7
58	R:R:F292	R:R:W94	11.02	Yes	Yes	3	7	7
59	R:R:W94	W:W:?1	23.24	Yes	Yes	3	7	0
60	R:R:F104	R:R:V96	6.55	Yes	No	0	7	5
61	R:R:D97	R:R:W102	4.47	No	Yes	0	5	9
62	R:R:D97	W:W:?1	27.69	No	Yes	0	5	0
63	R:R:N101	R:R:Y103	6.98	No	No	0	4	3
64	R:R:N101	R:R:R183	3.62	No	Yes	0	4	3
65	R:R:N101	R:R:Y184	5.81	No	No	0	4	5
66	R:R:F104	R:R:W102	20.04	Yes	Yes	4	7	9
67	R:R:C109	R:R:W102	3.92	No	Yes	4	9	9
68	R:R:C186	R:R:W102	19.59	No	Yes	4	9	9
69	R:R:F104	R:R:L108	6.09	Yes	No	4	7	5
70	R:R:K110	R:R:N106	5.6	No	No	0	7	3
71	R:R:C109	R:R:C186	7.28	No	No	4	9	9
72	R:R:K110	R:R:N176	4.2	No	No	0	7	4
73	R:R:A175	R:R:H113	5.85	No	No	0	4	6
74	R:R:H113	R:R:R188	7.9	No	Yes	3	6	5
75	R:R:H113	W:W:?1	7.77	No	Yes	3	6	0
76	R:R:T168	R:R:V114	9.52	No	No	0	6	5
77	R:R:F172	R:R:V114	13.11	No	No	0	4	5
78	R:R:L120	R:R:Y116	8.21	No	Yes	0	7	6
79	R:R:E288	R:R:Y116	7.86	Yes	Yes	3	5	6
80	R:R:F292	R:R:Y116	8.25	Yes	Yes	3	7	6
81	R:R:Y116	W:W:?1	4.43	Yes	Yes	3	6	0
82	R:R:T117	R:R:T168	4.71	No	No	0	5	6
83	R:R:D171	R:R:T117	8.67	No	No	0	4	5
84	R:R:H203	R:R:L120	3.86	Yes	No	0	4	7
85	R:R:H203	R:R:Y121	5.44	Yes	No	0	4	7
86	R:R:V206	R:R:Y121	6.31	No	No	0	4	7
87	R:R:F248	R:R:S123	5.28	Yes	No	0	9	9
88	R:R:P211	R:R:V124	7.07	No	No	0	9	7
89	R:R:F248	R:R:V124	3.93	Yes	No	0	9	7
90	R:R:A128	R:R:W125	3.89	No	No	0	7	5
91	R:R:V160	R:R:W125	3.68	No	No	0	7	5
92	R:R:P211	R:R:W125	24.32	No	No	0	9	5
93	R:R:I245	R:R:L127	7.14	No	No	0	7	8
94	R:R:F248	R:R:L127	7.31	Yes	No	0	9	8
95	R:R:F129	R:R:L132	3.65	Yes	No	0	5	6
96	R:R:F129	R:R:L151	3.65	Yes	No	5	5	4
97	R:R:F129	R:R:V155	3.93	Yes	No	5	5	2
98	R:R:F129	R:R:V156	3.93	Yes	No	0	5	5
99	R:R:F129	R:R:V160	7.87	Yes	No	0	5	7
100	R:R:I130	R:R:T241	4.56	No	No	0	8	7
101	R:R:I215	R:R:S131	7.74	No	No	8	7	9
102	R:R:S131	R:R:Y219	5.09	No	Yes	8	9	8
103	R:R:D133	R:R:R134	9.53	Yes	Yes	0	8	9
104	R:R:D133	R:R:R148	13.1	Yes	Yes	5	8	6
105	R:R:R134	R:R:T241	6.47	Yes	No	0	9	7
106	R:R:L136	R:R:Y135	3.52	No	Yes	0	5	8
107	R:R:V139	R:R:Y135	6.31	No	Yes	6	7	8
108	R:R:H140	R:R:Y135	11.98	Yes	Yes	6	6	8
109	R:R:L136	R:R:R148	4.86	No	Yes	0	5	6
110	R:R:A137	R:R:K236	4.82	No	No	0	8	8
111	R:R:I138	R:R:I222	7.36	No	No	12	8	8
112	R:R:H140	R:R:V139	9.69	Yes	No	6	6	7
113	R:R:H140	S:S:H140	7.17	Yes	Yes	6	6	6
114	R:R:N143	S:S:N143	12.26	No	No	0	5	5
115	R:R:K149	R:R:R146	3.71	No	No	0	6	5
116	R:R:E153	R:R:K149	5.4	No	No	0	7	6
117	R:R:L150	R:R:V155	4.47	No	No	0	4	2
118	R:R:L151	R:R:V155	5.96	No	No	5	4	2
119	R:R:I162	R:R:V158	7.68	No	No	0	4	4
120	R:R:G159	R:R:P163	4.06	No	No	0	3	4
121	R:R:L167	R:R:Q202	5.32	No	No	0	5	3
122	R:R:F199	R:R:P170	7.22	Yes	No	0	5	8
123	R:R:D171	R:R:R188	4.76	No	Yes	0	4	5
124	R:R:F174	R:R:Y190	13.41	Yes	Yes	0	4	4
125	R:R:F174	R:R:P191	4.33	Yes	No	9	4	5
126	R:R:F174	R:R:W195	4.01	Yes	Yes	9	4	5
127	R:R:F189	R:R:S178	3.96	No	No	0	3	1
128	R:R:E179	R:R:Y184	26.93	No	No	0	2	5
129	R:R:I185	R:R:R183	3.76	No	Yes	0	3	3
130	R:R:R183	W:W:?1	5.51	Yes	Yes	0	3	0
131	R:R:D187	R:R:F189	7.17	No	No	0	3	3
132	R:R:D187	W:W:?1	4.1	No	Yes	0	3	0
133	R:R:R188	R:R:Y190	13.38	Yes	Yes	0	5	4
134	R:R:R188	W:W:?1	4.59	Yes	Yes	3	5	0
135	R:R:F199	R:R:Y190	6.19	Yes	Yes	0	5	4
136	R:R:N192	R:R:P191	13.03	No	No	9	1	5
137	R:R:P191	R:R:W195	13.51	No	Yes	9	5	5
138	R:R:N192	R:R:W195	13.56	No	Yes	9	1	5
139	R:R:N192	S:S:E268	6.57	No	No	0	1	2
140	R:R:F199	R:R:W195	5.01	Yes	Yes	0	5	5
141	R:R:W195	S:S:L267	6.83	Yes	No	0	5	1
142	R:R:W195	S:S:I269	3.52	Yes	No	0	5	1
143	R:R:V197	S:S:L194	5.96	No	Yes	0	3	2
144	R:R:V198	S:S:F201	7.87	No	No	0	3	4
145	R:R:V198	S:S:L267	4.47	No	No	0	3	1
146	R:R:F199	R:R:Q202	5.86	Yes	No	0	5	3
147	R:R:H203	R:R:Q200	4.95	Yes	No	0	4	5
148	R:R:F201	S:S:F201	7.5	No	No	0	4	4
149	R:R:F201	S:S:M205	6.22	No	No	0	4	4
150	R:R:H203	R:R:I204	3.98	Yes	No	0	4	5
151	R:R:I204	R:R:I209	4.42	No	No	0	5	4
152	R:R:I209	R:R:M205	7.29	No	No	0	4	4
153	R:R:L210	R:R:M205	7.07	No	No	0	6	4
154	R:R:M205	S:S:M205	15.88	No	No	0	4	4
155	R:R:L208	R:R:Y256	11.72	No	No	0	8	8
156	R:R:I215	R:R:Y219	3.63	No	Yes	8	7	8
157	R:R:I215	R:R:I245	5.89	No	No	8	7	7
158	R:R:V242	R:R:Y219	5.05	No	Yes	0	4	8
159	R:R:I245	R:R:Y219	8.46	No	Yes	8	7	8
160	R:R:H228	R:R:K225	5.24	No	No	0	5	4
161	R:R:I243	R:R:L301	5.71	No	No	0	5	7
162	R:R:F249	R:R:L246	3.65	No	No	0	4	5
163	R:R:A247	R:R:L297	4.73	No	No	0	6	6
164	R:R:F248	R:R:W252	10.02	Yes	Yes	11	9	9
165	R:R:F248	R:R:H294	10.18	Yes	Yes	11	9	9
166	R:R:F249	R:R:L253	6.09	No	No	0	4	5
167	R:R:W252	R:R:Y255	7.72	Yes	Yes	0	9	7
168	R:R:W252	R:R:Y256	10.61	Yes	No	0	9	8
169	R:R:A291	R:R:W252	9.08	No	Yes	0	8	9
170	R:R:H294	R:R:W252	9.52	Yes	Yes	11	9	9
171	R:R:P254	R:R:T287	5.25	No	No	0	9	6
172	R:R:I259	R:R:Y255	12.09	No	Yes	0	5	7
173	R:R:T287	R:R:Y255	4.99	No	Yes	0	6	7
174	R:R:E288	R:R:Y255	5.61	Yes	Yes	0	5	7
175	R:R:G258	R:R:I284	3.53	No	No	0	4	4
176	R:R:I259	R:R:I284	4.42	No	No	0	5	4
177	R:R:D262	R:R:L266	4.07	No	No	0	5	3
178	R:R:F264	R:R:I269	8.79	No	No	0	4	1
179	R:R:E277	R:R:I265	4.1	No	No	0	2	3
180	R:R:L266	S:S:L194	4.15	No	Yes	0	3	2
181	R:R:I269	R:R:L267	4.28	No	Yes	1	1	1
182	R:R:L267	S:S:L194	5.54	Yes	Yes	0	1	2
183	R:R:L267	S:S:W195	13.67	Yes	Yes	1	1	5
184	R:R:E268	S:S:N192	6.57	No	No	0	2	1
185	R:R:I269	S:S:W195	3.52	No	Yes	1	1	5
186	R:R:F276	R:R:V280	3.93	No	No	0	1	5
187	R:R:K282	R:R:W283	23.21	No	No	7	2	6
188	R:R:I286	R:R:K282	5.82	Yes	No	7	6	2
189	R:R:I286	R:R:W283	3.52	Yes	No	7	6	6
190	R:R:E288	R:R:F292	5.83	Yes	Yes	3	5	7
191	R:R:E288	W:W:?1	12.02	Yes	Yes	3	5	0
192	R:R:C296	R:R:F293	4.19	No	No	0	7	5
193	R:R:C295	R:R:H294	7.37	No	Yes	0	9	9
194	S:S:F36	S:S:F40	11.79	No	No	0	4	5
195	S:S:I286	S:S:N37	4.25	No	No	0	6	3
196	S:S:F40	S:S:I44	7.54	No	No	0	5	5
197	S:S:L41	S:S:Y45	11.72	No	Yes	0	6	7
198	S:S:P42	S:S:V99	3.53	No	No	0	5	4
199	S:S:L91	S:S:Y45	3.52	No	Yes	1	8	7
200	S:S:W94	S:S:Y45	11.58	Yes	Yes	1	7	7
201	S:S:A289	S:S:Y45	5.34	No	Yes	0	4	7
202	S:S:F292	S:S:I48	3.77	Yes	No	0	7	7
203	S:S:F49	S:S:I53	3.77	No	Yes	0	6	5
204	S:S:F49	S:S:P92	7.22	No	No	0	6	9
205	S:S:C296	S:S:T51	5.07	No	No	0	7	5
206	S:S:G52	S:S:V88	5.52	No	No	0	8	6
207	S:S:I53	S:S:V88	4.61	Yes	No	0	5	6
208	S:S:G55	S:S:P299	4.06	No	Yes	0	8	9
209	S:S:N56	S:S:S81	8.94	No	No	0	9	9
210	S:S:D84	S:S:N56	6.73	Yes	No	0	9	9
211	S:S:N56	S:S:P299	11.4	No	Yes	0	9	9
212	S:S:S81	S:S:V59	8.08	No	No	0	9	8
213	S:S:P299	S:S:V59	3.53	Yes	No	0	9	8
214	S:S:I60	S:S:L85	5.71	Yes	No	0	7	7
215	S:S:L78	S:S:M63	5.65	No	No	0	5	6
216	S:S:D74	S:S:S71	4.42	No	No	0	8	7
217	S:S:D133	S:S:M72	6.93	Yes	Yes	2	8	6
218	S:S:M72	S:S:R148	8.69	Yes	Yes	2	6	6
219	S:S:A152	S:S:M72	4.83	No	Yes	0	3	6
220	S:S:R134	S:S:T73	11.64	Yes	No	0	9	7
221	S:S:F129	S:S:Y76	8.25	Yes	Yes	2	5	7
222	S:S:I130	S:S:Y76	7.25	No	Yes	0	8	7
223	S:S:D133	S:S:Y76	5.75	Yes	Yes	2	8	7
224	S:S:L151	S:S:Y76	3.52	Yes	Yes	2	4	7
225	S:S:A152	S:S:Y76	5.34	No	Yes	0	3	7
226	S:S:V156	S:S:Y76	3.79	Yes	Yes	2	5	7
227	S:S:N298	S:S:R77	9.64	No	Yes	0	9	8
228	S:S:L301	S:S:R77	3.64	No	Yes	0	7	8
229	S:S:R77	S:S:Y302	21.61	Yes	No	0	8	9
230	S:S:H79	S:S:V156	11.07	No	Yes	2	9	5
231	S:S:H79	S:S:Y157	7.62	No	No	2	9	7
232	S:S:H79	S:S:W161	10.58	No	No	0	9	9
233	S:S:D84	S:S:L80	6.79	Yes	No	0	9	9
234	S:S:I126	S:S:L80	4.28	No	No	0	7	9
235	S:S:L80	S:S:N298	6.87	No	No	0	9	9
236	S:S:D84	S:S:N119	4.04	Yes	No	0	9	8
237	S:S:C295	S:S:D84	9.34	No	Yes	0	9	9
238	S:S:I115	S:S:L86	5.71	No	No	0	5	7
239	S:S:F87	S:S:T90	3.89	Yes	No	1	7	6
240	S:S:F87	S:S:L91	7.31	Yes	No	1	7	8
241	S:S:F87	S:S:W94	6.01	Yes	Yes	1	7	7
242	S:S:F87	S:S:Y116	8.25	Yes	Yes	1	7	6
243	S:S:F87	S:S:N119	15.71	Yes	No	0	7	8
244	S:S:F292	S:S:F87	13.93	Yes	Yes	1	7	7
245	S:S:T90	S:S:W94	4.85	No	Yes	1	6	7
246	S:S:I115	S:S:T90	7.6	No	No	0	5	6
247	S:S:L91	S:S:W94	6.83	No	Yes	1	8	7
248	S:S:F104	S:S:F93	12.86	No	No	0	7	6
249	S:S:F93	S:S:L108	3.65	No	No	0	6	5
250	S:S:F93	S:S:V112	3.93	No	No	0	6	5
251	S:S:W94	S:S:Y116	10.61	Yes	Yes	1	7	6
252	S:S:F292	S:S:W94	7.02	Yes	Yes	1	7	7
253	K:K:?1	S:S:W94	13.77	Yes	Yes	1	0	7
254	S:S:F104	S:S:V96	6.55	No	No	0	7	5
255	S:S:D97	S:S:R183	4.76	No	Yes	1	5	3
256	K:K:?1	S:S:D97	20.51	Yes	No	1	0	5
257	S:S:A100	S:S:Y103	4	No	No	0	5	3
258	S:S:N101	S:S:Y103	18.61	No	No	0	4	3
259	S:S:N101	S:S:R183	3.62	No	Yes	0	4	3
260	S:S:F104	S:S:W102	16.04	No	Yes	0	7	9
261	S:S:C109	S:S:W102	3.92	No	Yes	1	9	9
262	S:S:V177	S:S:W102	7.36	No	Yes	0	4	9
263	S:S:C186	S:S:W102	18.28	No	Yes	1	9	9
264	S:S:K110	S:S:N106	4.2	No	No	13	7	3
265	S:S:N106	S:S:N176	12.26	No	No	13	3	4
266	S:S:N106	S:S:V177	7.39	No	No	0	3	4
267	S:S:C109	S:S:C186	7.28	No	No	1	9	9
268	S:S:K110	S:S:N176	5.6	No	No	13	7	4
269	S:S:A175	S:S:H113	8.78	No	No	0	4	6
270	S:S:H113	S:S:R188	6.77	No	Yes	1	6	5
271	K:K:?1	S:S:H113	6.8	Yes	No	1	0	6
272	S:S:T168	S:S:V114	11.11	No	No	0	6	5
273	S:S:F172	S:S:V114	9.18	No	No	0	4	5
274	S:S:L120	S:S:Y116	17.58	No	Yes	0	7	6
275	S:S:E288	S:S:Y116	7.86	No	Yes	1	5	6
276	S:S:F292	S:S:Y116	6.19	Yes	Yes	1	7	6
277	K:K:?1	S:S:Y116	4.43	Yes	Yes	1	0	6
278	S:S:D171	S:S:T117	11.56	No	No	0	4	5
279	S:S:H294	S:S:N119	7.65	Yes	No	0	9	8
280	S:S:H203	S:S:L120	5.14	No	No	0	4	7
281	S:S:L167	S:S:Y121	10.55	No	No	0	5	7
282	S:S:H203	S:S:Y121	7.62	No	No	0	4	7
283	S:S:S122	S:S:W161	6.18	No	No	0	7	9
284	S:S:F248	S:S:S123	5.28	Yes	No	10	9	9
285	S:S:H294	S:S:S123	4.18	Yes	No	10	9	9
286	S:S:P211	S:S:V124	8.84	No	No	0	9	7
287	S:S:F248	S:S:V124	5.24	Yes	No	0	9	7
288	S:S:A128	S:S:W125	3.89	No	Yes	0	7	5
289	S:S:V160	S:S:W125	3.68	No	Yes	0	7	5
290	S:S:P211	S:S:W125	17.57	No	Yes	0	9	5
291	S:S:I245	S:S:L127	8.56	No	No	0	7	8
292	S:S:F248	S:S:L127	8.53	Yes	No	0	9	8
293	S:S:F129	S:S:L151	3.65	Yes	Yes	2	5	4
294	S:S:F129	S:S:V155	3.93	Yes	No	2	5	2
295	S:S:F129	S:S:V156	3.93	Yes	Yes	2	5	5
296	S:S:F129	S:S:V160	7.87	Yes	No	0	5	7
297	S:S:I130	S:S:T241	4.56	No	No	0	8	7
298	S:S:I215	S:S:S131	6.19	No	No	0	7	9
299	S:S:L132	S:S:L151	4.15	No	Yes	0	6	4
300	S:S:D133	S:S:R134	5.96	Yes	Yes	2	8	9
301	S:S:D133	S:S:R148	15.48	Yes	Yes	2	8	6
302	S:S:A137	S:S:R134	4.15	No	Yes	2	8	9
303	S:S:K236	S:S:R134	6.19	No	Yes	2	8	9
304	S:S:R134	S:S:T241	5.17	Yes	No	0	9	7
305	S:S:L136	S:S:Y135	4.69	No	Yes	0	5	8
306	S:S:V139	S:S:Y135	7.57	No	Yes	6	7	8
307	S:S:H140	S:S:Y135	10.89	Yes	Yes	6	6	8
308	S:S:C218	S:S:Y135	4.03	No	Yes	0	6	8
309	S:S:I221	S:S:Y135	6.04	No	Yes	0	4	8
310	S:S:L136	S:S:R148	6.07	No	Yes	0	5	6
311	S:S:A137	S:S:R148	4.15	No	Yes	2	8	6
312	S:S:A137	S:S:K236	4.82	No	No	2	8	8
313	S:S:I138	S:S:I222	7.36	No	No	2	8	8
314	S:S:H140	S:S:V139	11.07	Yes	No	6	6	7
315	S:S:K225	S:S:V139	7.59	No	No	0	4	7
316	S:S:H140	S:S:N143	3.83	Yes	No	0	6	5
317	S:S:P147	S:S:S144	3.56	No	No	0	4	5
318	S:S:K149	S:S:R146	9.9	No	No	0	6	5
319	S:S:L151	S:S:V155	11.92	Yes	No	2	4	2
320	S:S:V156	S:S:Y157	7.57	Yes	No	2	5	7
321	S:S:G159	S:S:P163	4.06	No	No	0	3	4
322	S:S:L167	S:S:Q202	5.32	No	No	0	5	3
323	S:S:F199	S:S:P170	11.56	Yes	No	0	5	8
324	S:S:D171	S:S:R188	5.96	No	Yes	0	4	5
325	S:S:F174	S:S:I173	10.05	Yes	No	0	4	3
326	S:S:F174	S:S:Y190	11.35	Yes	Yes	1	4	4
327	S:S:F174	S:S:P191	4.33	Yes	No	1	4	5
328	S:S:F174	S:S:W195	6.01	Yes	Yes	1	4	5
329	S:S:V177	S:S:Y184	3.79	No	No	0	4	5
330	S:S:I185	S:S:S178	4.64	No	No	0	3	1
331	S:S:F189	S:S:S178	5.28	No	No	0	3	1
332	S:S:E179	S:S:Y184	15.71	No	No	0	2	5
333	S:S:I185	S:S:R183	7.52	No	Yes	0	3	3
334	K:K:?1	S:S:R183	9.18	Yes	Yes	1	0	3
335	K:K:?1	S:S:C186	3.6	Yes	No	1	0	9
336	S:S:D187	S:S:F189	8.36	No	No	0	3	3
337	K:K:?1	S:S:D187	4.1	Yes	No	0	0	3
338	S:S:R188	S:S:Y190	12.35	Yes	Yes	1	5	4
339	K:K:?1	S:S:R188	4.59	Yes	Yes	1	0	5
340	S:S:W195	S:S:Y190	3.86	Yes	Yes	1	5	4
341	S:S:V196	S:S:Y190	3.79	No	Yes	0	4	4
342	S:S:F199	S:S:Y190	5.16	Yes	Yes	1	5	4
343	S:S:P191	S:S:W195	17.57	No	Yes	1	5	5
344	S:S:L194	S:S:N192	4.12	Yes	No	0	2	1
345	S:S:N192	S:S:W195	9.04	No	Yes	0	1	5
346	S:S:F199	S:S:W195	5.01	Yes	Yes	1	5	5
347	S:S:F199	S:S:Q202	8.2	Yes	No	0	5	3
348	S:S:I209	S:S:M205	4.37	No	No	0	4	4
349	S:S:G207	S:S:P211	4.06	No	No	0	5	9
350	S:S:L208	S:S:Y256	11.72	No	No	0	8	8
351	S:S:I223	S:S:Y219	3.63	No	No	0	4	8
352	S:S:I243	S:S:L301	5.71	No	No	0	5	7
353	S:S:A247	S:S:L297	6.3	No	No	0	6	6
354	S:S:F248	S:S:F249	4.29	Yes	No	0	9	4
355	S:S:F248	S:S:W252	9.02	Yes	Yes	10	9	9
356	S:S:F248	S:S:H294	7.92	Yes	Yes	10	9	9
357	S:S:W252	S:S:Y255	7.72	Yes	Yes	0	9	7
358	S:S:W252	S:S:Y256	7.72	Yes	No	0	9	8
359	S:S:A291	S:S:W252	6.48	No	Yes	0	8	9
360	S:S:H294	S:S:W252	12.7	Yes	Yes	10	9	9
361	S:S:I259	S:S:Y255	8.46	No	Yes	0	5	7
362	S:S:T287	S:S:Y255	3.75	Yes	Yes	0	6	7
363	S:S:E288	S:S:Y255	12.35	No	Yes	0	5	7
364	S:S:I261	S:S:V280	6.14	No	No	0	5	5
365	S:S:D262	S:S:H281	7.56	No	No	0	5	4
366	S:S:D262	S:S:I284	4.2	No	No	0	5	4
367	S:S:F264	S:S:I269	7.54	No	No	0	4	1
368	S:S:I265	S:S:I270	7.36	No	No	0	3	5
369	S:S:E277	S:S:I265	5.47	No	No	0	2	3
370	S:S:E275	S:S:F276	4.66	No	No	0	3	1
371	S:S:F276	S:S:T279	3.89	No	No	0	1	2
372	S:S:E277	S:S:H281	7.39	No	No	0	2	4
373	S:S:T287	S:S:W283	4.85	Yes	No	0	6	6
374	K:K:?1	S:S:E288	14.02	Yes	No	1	0	5
375	S:S:C295	S:S:H294	7.37	No	Yes	0	9	9
376	S:S:N298	S:S:P299	6.52	No	Yes	0	9	9
377	S:S:P254	S:S:T287	3.5	No	Yes	0	9	6
378	R:R:C218	R:R:S131	3.44	No	No	0	6	9
379	S:S:C218	S:S:S131	3.44	No	No	0	6	9
380	R:R:C295	R:R:V88	3.42	No	No	0	9	6
381	R:R:C109	R:R:V177	3.42	No	No	0	9	4
382	S:S:A83	S:S:S122	3.42	No	No	0	8	7
383	S:S:C295	S:S:V88	3.42	No	No	0	9	6
384	R:R:A128	R:R:V214	3.39	No	No	0	7	6
385	R:R:I162	R:R:P163	3.39	No	No	0	4	4
386	R:R:I169	R:R:P170	3.39	No	No	0	3	8
387	S:S:I162	S:S:P163	3.39	No	No	0	4	4
388	S:S:I169	S:S:P170	3.39	No	No	0	3	8
389	R:R:L136	R:R:P147	3.28	No	No	0	5	4
390	S:S:C296	S:S:I48	3.27	No	No	0	7	7
391	R:R:A289	R:R:I44	3.25	No	No	0	4	5
392	S:S:A289	S:S:I44	3.25	No	No	0	4	5
393	R:R:V197	S:S:V197	3.21	No	No	0	3	3
394	R:R:S71	R:R:T73	3.2	No	No	0	7	7
395	S:S:T168	S:S:V118	3.17	No	No	0	6	5
396	S:S:C251	S:S:L297	3.17	No	No	0	8	6
397	S:S:A98	S:S:L41	3.15	No	No	0	5	6
398	S:S:T117	S:S:T168	3.14	No	No	0	5	6
399	S:S:I60	S:S:S81	3.1	Yes	No	0	7	9
400	R:R:I53	R:R:V88	3.07	No	No	0	5	6
401	R:R:I261	R:R:V280	3.07	No	No	0	5	5
402	R:R:K38	R:R:S285	3.06	No	No	0	4	5
403	R:R:M63	R:R:V62	3.04	No	No	0	6	7
404	R:R:I115	R:R:T90	3.04	No	No	0	5	6
405	R:R:K225	R:R:V139	3.04	No	No	0	4	7
406	S:S:I300	S:S:T51	3.04	No	No	0	6	5
407	S:S:M63	S:S:V62	3.04	No	No	0	6	7
408	S:S:I286	S:S:T287	3.04	No	Yes	0	6	6
409	R:R:L267	S:S:V198	2.98	Yes	No	0	1	3
410	S:S:N37	S:S:S285	2.98	No	No	0	3	5
411	S:S:L167	S:S:V206	2.98	No	No	0	5	4
412	S:S:L246	S:S:V242	2.98	No	No	0	5	4
413	R:R:N106	R:R:V177	2.96	No	No	0	3	4
414	R:R:C251	R:R:H294	2.95	No	Yes	0	8	9
415	S:S:C251	S:S:H294	2.95	No	Yes	0	8	9
416	S:S:I53	S:S:I89	2.94	Yes	No	0	5	4
417	S:S:I261	S:S:I265	2.94	No	No	0	5	3
418	S:S:D193	S:S:V196	2.92	No	No	0	1	4
419	R:R:G207	R:R:Y121	2.9	No	No	0	5	7
420	S:S:Q200	S:S:V196	2.87	No	No	0	5	4
421	R:R:I286	R:R:L41	2.85	Yes	No	0	6	6
422	R:R:I48	R:R:L91	2.85	No	No	0	7	8
423	R:R:I53	R:R:L85	2.85	No	No	0	5	7
424	R:R:I126	R:R:L80	2.85	No	No	0	7	9
425	R:R:I138	R:R:L226	2.85	No	No	12	8	8
426	R:R:I162	R:R:L166	2.85	No	No	0	4	4
427	R:R:I169	R:R:L166	2.85	No	No	0	3	4
428	R:R:I213	S:S:L210	2.85	No	No	0	3	6
429	R:R:I222	R:R:L226	2.85	No	No	12	8	8
430	R:R:I257	R:R:L253	2.85	No	No	0	6	5
431	S:S:I44	S:S:L290	2.85	No	No	0	5	7
432	S:S:I138	S:S:L238	2.85	No	No	2	8	5
433	S:S:I162	S:S:L166	2.85	No	No	0	4	4
434	S:S:I169	S:S:L166	2.85	No	No	0	3	4
435	S:S:I204	S:S:L208	2.85	No	No	0	5	8
436	S:S:I222	S:S:L226	2.85	No	No	0	8	8
437	S:S:I222	S:S:L238	2.85	No	No	2	8	5
438	S:S:I257	S:S:L253	2.85	No	No	0	6	5
439	R:R:K239	R:R:L238	2.82	No	No	0	6	5
440	R:R:E275	R:R:T279	2.82	No	No	0	3	2
441	R:R:G105	R:R:W102	2.81	No	Yes	0	8	9
442	S:S:G105	S:S:W102	2.81	No	Yes	0	8	9
443	R:R:H140	R:R:S144	2.79	Yes	No	0	6	5
444	R:R:L127	R:R:L244	2.77	No	No	0	8	7
445	S:S:L127	S:S:L244	2.77	No	No	0	8	7
446	S:S:L244	S:S:L301	2.77	No	No	0	7	7
447	R:R:K68	R:R:Q66	2.71	No	No	0	6	4
448	S:S:E153	S:S:K149	2.7	No	No	0	7	6
449	R:R:A95	R:R:Y45	2.67	No	Yes	0	7	7
450	S:S:A95	S:S:Y45	2.67	No	Yes	0	7	7
451	R:R:F264	R:R:S260	2.64	No	No	0	4	5
452	S:S:F264	S:S:S260	2.64	No	No	0	4	5
453	R:R:H281	R:R:N278	2.55	No	No	0	4	3
454	R:R:V196	R:R:Y190	2.52	No	Yes	0	4	4
455	R:R:F174	R:R:I173	2.51	Yes	No	0	4	3
456	R:R:F264	R:R:I270	2.51	No	No	0	4	5
457	S:S:F293	S:S:I47	2.51	No	No	0	5	4
458	S:S:F293	S:S:I48	2.51	No	No	0	5	7
459	R:R:K75	R:R:R70	2.48	No	No	0	6	6
460	S:S:M72	S:S:R146	2.48	Yes	No	0	6	5
461	S:S:V214	S:S:W125	2.45	No	Yes	0	6	5
462	R:R:F49	R:R:L50	2.44	No	No	0	6	5
463	R:R:F49	R:R:L91	2.44	No	No	0	6	8
464	S:S:F49	S:S:L50	2.44	No	No	0	6	5
465	S:S:F107	S:S:L108	2.44	No	No	0	1	5
466	R:R:L238	R:R:R134	2.43	No	Yes	0	5	9
467	S:S:L238	S:S:R134	2.43	No	Yes	2	5	9
468	R:R:I221	R:R:Y135	2.42	No	Yes	0	4	8
469	S:S:I284	S:S:Y255	2.42	No	Yes	0	4	7
470	S:S:D74	S:S:R77	2.38	No	Yes	0	8	8
471	S:S:D182	S:S:R183	2.38	No	Yes	0	6	3
472	S:S:L210	S:S:W125	2.28	No	Yes	0	6	5
473	R:R:H281	R:R:R30	2.26	No	No	0	4	5
474	R:R:A95	R:R:P42	1.87	No	No	0	7	5
475	R:R:A237	R:R:P240	1.87	No	No	0	7	7
476	S:S:A95	S:S:P42	1.87	No	No	0	7	5
477	S:S:A237	S:S:P240	1.87	No	No	0	7	7
478	R:R:G57	R:R:I60	1.76	No	No	0	3	7
479	S:S:G57	S:S:I60	1.76	No	Yes	0	3	7
480	S:S:G212	S:S:I215	1.76	No	No	0	6	7
481	S:S:G258	S:S:I284	1.76	No	No	0	4	4
482	R:R:G64	R:R:M63	1.75	No	No	0	2	6
483	R:R:A95	R:R:S46	1.71	No	No	0	7	5
484	R:R:G57	R:R:L85	1.71	No	No	0	3	7
485	R:R:G64	R:R:L78	1.71	No	No	0	2	5
486	R:R:A83	R:R:S122	1.71	No	No	0	8	7
487	R:R:A180	R:R:S178	1.71	No	No	0	1	1
488	S:S:A180	S:S:S178	1.71	No	No	0	1	1
489	R:R:A164	R:R:V118	1.7	No	No	0	7	5
490	R:R:I300	R:R:P299	1.69	No	Yes	0	6	9
491	R:R:A141	R:R:T142	1.68	No	No	0	8	5
492	R:R:K239	R:R:P240	1.67	No	No	0	6	7
493	S:S:K239	S:S:P240	1.67	No	No	0	6	7
494	R:R:C218	R:R:I222	1.64	No	No	0	6	8
495	R:R:C220	R:R:I223	1.64	No	No	0	3	4
496	R:R:L253	R:R:P254	1.64	No	No	0	5	9
497	S:S:L136	S:S:P147	1.64	No	No	0	5	4
498	S:S:L253	S:S:P254	1.64	No	No	0	5	9
499	R:R:S122	R:R:V160	1.62	No	No	0	7	7
500	R:R:A141	R:R:K236	1.61	No	No	0	8	8
501	S:S:A141	S:S:K236	1.61	No	No	0	8	8
502	R:R:I213	R:R:S217	1.55	No	No	0	3	3
503	R:R:I221	R:R:S217	1.55	No	No	0	4	3
504	R:R:I261	R:R:S260	1.55	No	No	0	5	5
505	R:R:I53	R:R:V54	1.54	No	No	0	5	4
506	R:R:I60	R:R:V82	1.54	No	No	0	7	5
507	S:S:I53	S:S:V54	1.54	Yes	No	0	5	4
508	S:S:I60	S:S:V82	1.54	Yes	No	0	7	5
509	R:R:K225	R:R:S224	1.53	No	No	0	4	4
510	R:R:I47	R:R:T43	1.52	No	No	0	4	4
511	R:R:I47	R:R:T51	1.52	No	No	0	4	5
512	S:S:I47	S:S:T43	1.52	No	No	0	4	4
513	S:S:M63	S:S:V59	1.52	No	No	0	6	8
514	R:R:L58	R:R:V54	1.49	No	No	0	5	4
515	R:R:L86	R:R:V118	1.49	No	No	0	7	5
516	R:R:L165	R:R:V118	1.49	No	No	0	3	5
517	R:R:L194	S:S:V197	1.49	No	No	0	2	3
518	S:S:L165	S:S:V118	1.49	No	No	0	3	5
519	S:S:I209	S:S:I213	1.47	No	No	0	4	3
520	R:R:I44	R:R:L290	1.43	No	No	0	5	7
521	R:R:Q66	R:R:V62	1.43	No	No	0	4	7
522	R:R:I286	R:R:L290	1.43	Yes	No	0	6	7
523	S:S:I223	S:S:L226	1.43	No	No	0	4	8
524	S:S:K154	S:S:L150	1.41	No	No	0	3	4
525	S:S:K38	S:S:N35	1.4	No	No	0	4	3
526	S:S:K282	S:S:N37	1.4	No	No	0	2	3
527	R:R:H281	R:R:S285	1.39	No	No	0	4	5
528	R:R:A137	R:R:R148	1.38	No	Yes	0	8	6
529	R:R:L194	S:S:L266	1.38	No	No	0	2	3
530	R:R:L244	R:R:L297	1.38	No	No	0	7	6
531	R:R:L244	R:R:L301	1.38	No	No	0	7	7
532	S:S:L266	S:S:L267	1.38	No	No	0	3	1
533	S:S:K271	S:S:Q272	1.36	No	No	0	3	2
534	R:R:E268	R:R:K271	1.35	No	No	0	2	3
535	R:R:A100	R:R:Y103	1.33	No	No	0	5	3
536	S:S:A164	S:S:Y121	1.33	No	No	0	7	7
537	R:R:F107	R:R:L108	1.22	No	No	0	1	5
538	R:R:D181	R:R:R183	1.19	No	Yes	0	2	3
539	S:S:K75	S:S:Y157	1.19	No	No	0	6	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N37	8.4875	4	7	3
2	R:R:Y45	6.834	5	3	7
3	R:R:Y76	5.094	5	5	7
4	R:R:D84	7.445	4	0	9
5	R:R:F93	7.75	4	4	6
6	R:R:W94	12.79	5	3	7
7	R:R:W102	10.166	5	4	9
8	R:R:F104	12.725	4	4	7
9	R:R:Y116	7.61333	6	3	6
10	R:R:F129	4.87	6	5	5
11	R:R:D133	8.135	4	5	8
12	R:R:R134	5.9	4	0	9
13	R:R:Y135	6.0575	4	6	8
14	R:R:H140	7.9075	4	6	6
15	R:R:R148	7.3175	4	5	6
16	R:R:F174	6.065	4	9	4
17	R:R:R183	3.52	4	0	3
18	R:R:R188	7.6575	4	3	5
19	R:R:Y190	8.875	4	0	4
20	R:R:W195	7.74	6	9	5
21	R:R:F199	6.07	4	0	5
22	R:R:H203	4.5575	4	0	4
23	R:R:Y219	5.5575	4	8	8
24	R:R:F248	7.344	5	11	9
25	R:R:W252	9.39	5	11	9
26	R:R:Y255	7.6025	4	0	7
27	R:R:L267	6.6175	4	1	1
28	R:R:I286	3.574	5	7	6
29	R:R:E288	7.572	5	3	5
30	R:R:F292	7.776	5	3	7
31	R:R:H294	7.505	4	11	9
32	R:R:P299	5.17	4	0	9
33	S:S:Y45	6.966	5	1	7
34	S:S:I53	3.215	4	0	5
35	S:S:I60	3.0275	4	0	7
36	S:S:M72	5.7325	4	2	6
37	S:S:Y76	5.65	6	2	7
38	S:S:R77	9.3175	4	0	8
39	S:S:D84	6.725	4	0	9
40	S:S:F87	9.18333	6	1	7
41	S:S:W94	8.66714	7	1	7
42	S:S:W102	9.682	5	1	9
43	S:S:Y116	9.15333	6	1	6
44	S:S:W125	5.974	5	0	5
45	S:S:F129	5.526	5	2	5
46	S:S:D133	8.53	4	2	8
47	S:S:R134	5.92333	6	2	9
48	S:S:Y135	6.644	5	6	8
49	S:S:H140	8.24	4	6	6
50	S:S:R148	8.5975	4	2	6
51	S:S:L151	5.81	4	2	4
52	S:S:V156	6.59	4	2	5
53	S:S:F174	7.935	4	1	4
54	S:S:R183	5.492	5	1	3
55	S:S:R188	7.4175	4	1	5
56	S:S:Y190	7.302	5	1	4
57	S:S:L194	4.9425	4	0	2
58	S:S:W195	8.38286	7	1	5
59	S:S:F199	7.4825	4	1	5
60	S:S:F248	6.71333	6	10	9
61	S:S:W252	8.728	5	10	9
62	S:S:Y255	6.94	5	0	7
63	S:S:T287	3.785	4	0	6
64	S:S:F292	7.7275	4	1	7
65	S:S:H294	7.12833	6	10	9
66	S:S:P299	6.3775	4	0	9
67	W:W:?1	11.1688	8	3	0
68	K:K:?1	9	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L41	R:R:Y45	15.0171	8.21	No	Yes	0	6	7
2	R:R:W94	R:R:Y45	25.4589	14.47	Yes	Yes	3	7	7
3	R:R:D84	R:R:N119	14.1604	6.73	Yes	No	0	9	8
4	R:R:F87	R:R:N119	14.767	15.71	No	No	0	7	8
5	R:R:D133	R:R:Y76	20.7904	5.75	Yes	Yes	5	8	7
6	R:R:F129	R:R:Y76	20.2626	6.19	Yes	Yes	5	5	7
7	R:R:F129	R:R:V160	20.2311	7.87	Yes	No	0	5	7
8	R:R:V160	R:R:W125	20.2443	3.68	No	No	0	7	5
9	R:R:P211	R:R:W125	20.3256	24.32	No	No	0	9	5
10	R:R:P211	R:R:V124	20.3879	7.07	No	No	0	9	7
11	R:R:F248	R:R:V124	20.5681	3.93	Yes	No	0	9	7
12	R:R:F248	R:R:W252	22.2254	10.02	Yes	Yes	11	9	9
13	R:R:W252	R:R:Y255	28.5576	7.72	Yes	Yes	0	9	7
14	R:R:E288	R:R:Y255	34.3152	5.61	Yes	Yes	0	5	7
15	R:R:D133	R:R:R148	20.2726	13.1	Yes	Yes	5	8	6
16	R:R:F104	R:R:W102	10.038	20.04	Yes	Yes	4	7	9
17	R:R:D97	R:R:W102	16.6297	4.47	No	Yes	0	5	9
18	R:R:D97	W:W:?1	17.448	27.69	No	Yes	0	5	0
19	R:R:W94	W:W:?1	23.1584	23.24	Yes	Yes	3	7	0
20	R:R:R188	W:W:?1	86.9748	4.59	Yes	Yes	3	5	0
21	R:R:F248	R:R:L127	10.782	7.31	Yes	No	0	9	8
22	R:R:L136	R:R:R148	21.535	4.86	No	Yes	0	5	6
23	R:R:L136	R:R:Y135	21.569	3.52	No	Yes	0	5	8
24	R:R:F199	R:R:Y190	46.5965	6.19	Yes	Yes	0	5	4
25	R:R:R188	R:R:Y190	91.213	13.38	Yes	Yes	0	5	4
26	R:R:F174	R:R:Y190	45.7246	13.41	Yes	Yes	0	4	4
27	R:R:F174	R:R:W195	45.6641	4.01	Yes	Yes	9	4	5
28	R:R:F199	R:R:W195	48.582	5.01	Yes	Yes	0	5	5
29	R:R:W195	S:S:L267	95.0726	6.83	Yes	No	0	5	1
30	S:S:L266	S:S:L267	99.5464	1.38	No	No	0	3	1
31	R:R:L194	S:S:L266	99.6239	1.38	No	No	0	2	3
32	R:R:L194	S:S:V197	99.7405	1.49	No	No	0	2	3
33	R:R:V197	S:S:V197	99.8608	3.21	No	No	0	3	3
34	R:R:V197	S:S:L194	100	5.96	No	Yes	0	3	2
35	R:R:L267	S:S:L194	51.0262	5.54	Yes	Yes	0	1	2
36	R:R:L267	S:S:W195	49.1376	13.67	Yes	Yes	1	1	5
37	S:S:L194	S:S:N192	49.4853	4.12	Yes	No	0	2	1
38	S:S:N192	S:S:W195	49.3537	9.04	No	Yes	0	1	5
39	S:S:W195	S:S:Y190	92.0256	3.86	Yes	Yes	1	5	4
40	S:S:R188	S:S:Y190	93.2345	12.35	Yes	Yes	1	5	4
41	K:K:?1	S:S:R188	89.8895	4.59	Yes	Yes	1	0	5
42	K:K:?1	S:S:W94	31.0647	13.77	Yes	Yes	1	0	7
43	K:K:?1	S:S:E288	26.6451	14.02	Yes	No	1	0	5
44	S:S:E288	S:S:Y255	27.3103	12.35	No	Yes	0	5	7
45	K:K:?1	S:S:Y116	23.685	4.43	Yes	Yes	1	0	6
46	S:S:F87	S:S:W94	19.7435	6.01	Yes	Yes	1	7	7
47	S:S:F87	S:S:N119	40.6391	15.71	Yes	No	0	7	8
48	S:S:D84	S:S:N119	28.6804	4.04	Yes	No	0	9	8
49	S:S:C295	S:S:V88	15.6369	3.42	No	No	0	9	6
50	S:S:I53	S:S:V88	11.7351	4.61	Yes	No	0	5	6
51	S:S:F87	S:S:Y116	19.3006	8.25	Yes	Yes	1	7	6
52	S:S:H294	S:S:N119	15.9935	7.65	Yes	No	0	9	8
53	S:S:C295	S:S:H294	13.2784	7.37	No	Yes	0	9	9
54	S:S:W252	S:S:Y255	20.2046	7.72	Yes	Yes	0	9	7
55	S:S:D84	S:S:N56	17.3378	6.73	Yes	No	0	9	9
56	R:R:I221	R:R:Y135	13.6911	2.42	No	Yes	0	4	8
57	R:R:I221	R:R:S217	13.6451	1.55	No	No	0	4	3
58	R:R:I213	R:R:S217	13.6312	1.55	No	No	0	3	3
59	R:R:I213	S:S:L210	13.6407	2.85	No	No	0	3	6
60	S:S:L210	S:S:W125	13.6892	2.28	No	Yes	0	6	5
61	S:S:V160	S:S:W125	10.1955	3.68	No	Yes	0	7	5
62	S:S:F248	S:S:W252	13.0825	9.02	Yes	Yes	10	9	9
63	K:K:?1	S:S:C186	11.1971	3.6	Yes	No	1	0	9
64	S:S:P211	S:S:W125	20.1435	17.57	No	Yes	0	9	5
65	S:S:P211	S:S:V124	20.1838	8.84	No	No	0	9	7
66	S:S:F248	S:S:V124	20.4087	5.24	Yes	No	0	9	7
67	R:R:F87	R:R:Y116	14.7878	8.25	No	Yes	3	7	6
68	R:R:Y116	W:W:?1	19.9407	4.43	Yes	Yes	3	6	0
69	R:R:E288	W:W:?1	27.1774	12.02	Yes	Yes	3	5	0

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:L91	S:S:Y45	3.52	1	No	Yes	8	7	2	2
S:S:W94	S:S:Y45	11.58	1	Yes	Yes	7	7	1	2
S:S:F87	S:S:T90	3.89	1	Yes	No	7	6	2	2
S:S:F87	S:S:L91	7.31	1	Yes	No	7	8	2	2
S:S:F87	S:S:W94	6.01	1	Yes	Yes	7	7	2	1
S:S:F87	S:S:Y116	8.25	1	Yes	Yes	7	6	2	1
S:S:F292	S:S:F87	13.93	1	Yes	Yes	7	7	2	2
S:S:T90	S:S:W94	4.85	1	No	Yes	6	7	2	1
S:S:L91	S:S:W94	6.83	1	No	Yes	8	7	2	1
S:S:W94	S:S:Y116	10.61	1	Yes	Yes	7	6	1	1
S:S:F292	S:S:W94	7.02	1	Yes	Yes	7	7	2	1
K:K:?1	S:S:W94	13.77	1	Yes	Yes	0	7	0	1
S:S:D97	S:S:R183	4.76	1	No	Yes	5	3	1	1
K:K:?1	S:S:D97	20.51	1	Yes	No	0	5	0	1
S:S:N101	S:S:R183	3.62	0	No	Yes	4	3	2	1
S:S:C109	S:S:W102	3.92	1	No	Yes	9	9	2	2
S:S:C186	S:S:W102	18.28	1	No	Yes	9	9	1	2
S:S:C109	S:S:C186	7.28	1	No	No	9	9	2	1
S:S:A175	S:S:H113	8.78	0	No	No	4	6	2	1
S:S:H113	S:S:R188	6.77	1	No	Yes	6	5	1	1
K:K:?1	S:S:H113	6.8	1	Yes	No	0	6	0	1
S:S:L120	S:S:Y116	17.58	0	No	Yes	7	6	2	1
S:S:E288	S:S:Y116	7.86	1	No	Yes	5	6	1	1
S:S:F292	S:S:Y116	6.19	1	Yes	Yes	7	6	2	1
K:K:?1	S:S:Y116	4.43	1	Yes	Yes	0	6	0	1
S:S:D171	S:S:R188	5.96	0	No	Yes	4	5	2	1
S:S:I185	S:S:R183	7.52	0	No	Yes	3	3	2	1
K:K:?1	S:S:R183	9.18	1	Yes	Yes	0	3	0	1
K:K:?1	S:S:C186	3.6	1	Yes	No	0	9	0	1
S:S:D187	S:S:F189	8.36	0	No	No	3	3	1	2
K:K:?1	S:S:D187	4.1	1	Yes	No	0	3	0	1
S:S:R188	S:S:Y190	12.35	1	Yes	Yes	5	4	1	2
K:K:?1	S:S:R188	4.59	1	Yes	Yes	0	5	0	1
S:S:E288	S:S:Y255	12.35	1	No	Yes	5	7	1	2
K:K:?1	S:S:E288	14.02	1	Yes	No	0	5	0	1
S:S:D182	S:S:R183	2.38	0	No	Yes	6	3	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:W94	R:R:Y45	14.47	3	Yes	Yes	7	7	1	2
R:R:F292	R:R:Y45	4.13	3	Yes	Yes	7	7	2	2
R:R:F87	R:R:Y116	8.25	3	No	Yes	7	6	2	1
R:R:F292	R:R:F87	9.65	3	Yes	No	7	7	2	2
R:R:W94	R:R:Y116	8.68	3	Yes	Yes	7	6	1	1
R:R:E288	R:R:W94	6.54	3	Yes	Yes	5	7	1	1
R:R:F292	R:R:W94	11.02	3	Yes	Yes	7	7	2	1
R:R:W94	W:W:?1	23.24	3	Yes	Yes	7	0	1	0
R:R:D97	R:R:W102	4.47	0	No	Yes	5	9	1	2
R:R:D97	W:W:?1	27.69	0	No	Yes	5	0	1	0
R:R:N101	R:R:R183	3.62	0	No	Yes	4	3	2	1
R:R:A175	R:R:H113	5.85	0	No	No	4	6	2	1
R:R:H113	R:R:R188	7.9	3	No	Yes	6	5	1	1
R:R:H113	W:W:?1	7.77	3	No	Yes	6	0	1	0
R:R:L120	R:R:Y116	8.21	0	No	Yes	7	6	2	1
R:R:E288	R:R:Y116	7.86	3	Yes	Yes	5	6	1	1
R:R:F292	R:R:Y116	8.25	3	Yes	Yes	7	6	2	1
R:R:Y116	W:W:?1	4.43	3	Yes	Yes	6	0	1	0
R:R:D171	R:R:R188	4.76	0	No	Yes	4	5	2	1
R:R:I185	R:R:R183	3.76	0	No	Yes	3	3	2	1
R:R:R183	W:W:?1	5.51	0	Yes	Yes	3	0	1	0
R:R:D187	R:R:F189	7.17	0	No	No	3	3	1	2
R:R:D187	W:W:?1	4.1	0	No	Yes	3	0	1	0
R:R:R188	R:R:Y190	13.38	3	Yes	Yes	5	4	1	2
R:R:R188	W:W:?1	4.59	3	Yes	Yes	5	0	1	0
R:R:E288	R:R:Y255	5.61	3	Yes	Yes	5	7	1	2
R:R:E288	R:R:F292	5.83	3	Yes	Yes	5	7	1	2
R:R:E288	W:W:?1	12.02	3	Yes	Yes	5	0	1	0
R:R:D181	R:R:R183	1.19	0	No	Yes	2	3	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	3OE9_poly
Class	A
SubFamily	Protein
Type	Chemokine
SubType	CXCR4
Species	Homo sapiens
Ligand	-
Other Ligand(s)	IT1t
Protein Partners	-
PDB Resolution	3.1
Date	2010-10-27
D.O.I.	10.1126/science.1194396

Net Summary
I_min	3.52
Number of Linked Nodes	481
Number of Links	539
Number of Hubs	68
Number of Links mediated by Hubs	256
Number of Communities	13
Number of Nodes involved in Communities	94
Number of Links involved in Communities	131

Path Summary
Number Of Nodes in MetaPath	70
Number Of Links MetaPath	69
Number of Shortest Paths	269034
Length Of Smallest Path	3
Average Path Length	20.7195
Length of Longest Path	37
Minimum Path Strength	1.38
Average Path Strength	6.98347
Maximum Path Strength	25.465
Minimum Path Correlation	0.7
Average Path Correlation	0.956596
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	42.1312
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.611
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ITD
PDB Residues	W:W:?1 K:K:?1
Environment Details	Open EMBL-EBI Page
Code	ITD
Name	(6,6-dimethyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-3-yl)methyl N,N'-dicyclohexylimidothiocarbamate
Synonyms
Identifier	(6,6-dimethyl-5H-imidazo[2,1-b][1,3]thiazol-3-yl)methyl N,N'-dicyclohexylcarbamimidothioate
Formula	C21 H34 N4 S2
Molecular Weight	406.651
SMILES	CC1(CN2C(=CSC2=N1)CS/C(=N\C3CCCCC3)/NC4CCCCC4)C
PubChem	25147749
Formal Charge	0
Total Atoms	61
Total Chiral Atoms	0
Total Bonds	64
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P61073
Sequence	>3OE9_poly_Chain_R C F R N F N K I F L P T I Y S I I F L T G I V G N G L V I L V M G Y Q K K L R S M T D K Y R L H L S V A D L L F V I T L P F W A V D A V A N W Y F G N F L C K A V H V I Y T V N L Y S S V W I L A F I S L D R Y L A I V H A T N S Q R P R K L L A E K V V Y V G V W I P A L L L T I P D F I F A N V S E A D D R Y I C D R F Y P N D L W V V V F Q F Q H I M V G L I L P G I V I L S C Y C I I I S K L S H K A L K P T V I L I L A F F A C W L P Y Y I G I S I D S F I L L E I I K C E F E N T V H K W I S I T E A L A F F H C C L N P I L Y A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	3ODU	A	Protein	Chemokine	CXCR4	Homo sapiens	-	IT1t	-	2.5	2010-10-27	10.1126/science.1194396
	3OE0	A	Protein	Chemokine	CXCR4	Homo sapiens	-	CVX15	-	2.9	2010-10-27	10.1126/science.1194396
	3OE6	A	Protein	Chemokine	CXCR4	Homo sapiens	-	IT1t	-	3.2	2010-10-27	10.1126/science.1194396
	3OE8	A	Protein	Chemokine	CXCR4	Homo sapiens	-	IT1t	-	3.1	2010-10-27	10.1126/science.1194396
	3OE9	A	Protein	Chemokine	CXCR4	Homo sapiens	-	IT1t	-	3.1	2010-10-27	10.1126/science.1194396
	4RWS	A	Protein	Chemokine	CXCR4	Homo sapiens	vMIP-II	-	-	3.1	2015-02-11	10.1126/science.1261064
	8U4N	A	Protein	Chemokine	CXCR4	Homo sapiens	-	Cholesterol	Gi1/&β;1/&γ;2	2.72	2024-03-13	10.1101/2024.02.09.579708
	8U4O	A	Protein	Chemokine	CXCR4	Homo sapiens	CXCL12	Cholesterol	Gi1/&β;1/&γ;2	3.29	2024-03-13	10.1101/2024.02.09.579708
	8U4P	A	Protein	Chemokine	CXCR4	Homo sapiens	AMD3100	Cholesterol	Gi1/&β;1/&γ;2	3.15	2024-03-13	10.1101/2024.02.09.579708
	8U4Q	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	Cholesterol	Gi1/&β;1/&γ;2	3.36	2024-03-13	10.1101/2024.02.09.579708
	8U4R	A	Protein	Chemokine	CXCR4	Homo sapiens	REGN7663-Fab	Cholesterol	-	3.1	2024-03-13	10.1101/2024.02.09.579708
	3ODU (Dimer)	A	Protein	Chemokine	CXCR4	Homo sapiens	-	IT1t	-	2.5	2010-10-27	10.1126/science.1194396
	3OE8 (Dimer)	A	Protein	Chemokine	CXCR4	Homo sapiens	-	IT1t	-	3.1	2010-10-27	10.1126/science.1194396
	3OE9 (Dimer)	A	Protein	Chemokine	CXCR4	Homo sapiens	-	IT1t	-	3.1	2010-10-27	10.1126/science.1194396

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 3OE9_poly.zip

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