Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 11.1688830
2M:M:?1 9910
3R:R:N37 8.4875473
4R:R:Y45 6.834537
5R:R:Y76 5.094557
6R:R:D84 7.445409
7R:R:F93 7.75446
8R:R:W94 12.79537
9R:R:W102 10.166549
10R:R:F104 12.725447
11R:R:Y116 7.61333636
12R:R:F129 4.87655
13R:R:D133 8.135458
14R:R:R134 9.315409
15R:R:Y135 6.0575468
16R:R:H140 8.9525466
17R:R:F174 6.0654124
18R:R:R183 3.52403
19R:R:R188 7.6575435
20R:R:Y190 8.875404
21R:R:W195 6.5765125
22R:R:F199 6.07405
23R:R:H203 4.5575404
24R:R:Y219 5.5575488
25R:R:K236 8.1025408
26R:R:F248 7.3445109
27R:R:W252 9.395109
28R:R:Y255 7.6025407
29R:R:L267 6.6175411
30R:R:I286 3.574576
31R:R:E288 7.572535
32R:R:F292 7.776537
33R:R:H294 7.5054109
34S:S:Y45 6.966517
35S:S:I53 3.215405
36S:S:I60 3.0275407
37S:S:M72 5.7325426
38S:S:Y76 5.65627
39S:S:R77 9.3175408
40S:S:D84 6.725409
41S:S:F87 9.18333617
42S:S:W94 8.66714717
43S:S:W102 9.682519
44S:S:Y116 9.15333616
45S:S:W125 5.974505
46S:S:F129 5.526525
47S:S:D133 8.53428
48S:S:R134 5.51609
49S:S:Y135 6.644568
50S:S:H140 8.24466
51S:S:R148 8.5975426
52S:S:L151 5.81424
53S:S:V156 6.59425
54S:S:F174 7.935414
55S:S:R183 5.492513
56S:S:R188 7.4175415
57S:S:Y190 7.302514
58S:S:L194 4.9425402
59S:S:W195 8.38286715
60S:S:F199 7.4825415
61S:S:F248 6.71333699
62S:S:W252 8.728599
63S:S:Y255 6.94507
64S:S:T287 3.785406
65S:S:F292 7.7275417
66S:S:H294 7.12833699
67S:S:P299 6.3775409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:R188 85.744.59YesYes305
2R:R:R188 R:R:Y190 90.070813.38YesYes054
3R:R:F174 R:R:Y190 45.25113.41YesYes044
4R:R:F174 R:R:W195 45.06524.01YesYes1245
5R:R:W195 S:S:L267 94.95666.83YesNo051
6S:S:L266 S:S:L267 99.52831.38NoNo031
7R:R:L194 S:S:L266 99.59881.38NoNo023
8R:R:L194 S:S:V197 99.7271.49NoNo023
9R:R:V197 S:S:V197 99.8593.21NoNo033
10R:R:V197 S:S:L194 1005.96NoYes032
11R:R:L267 S:S:L194 51.02575.54YesYes012
12R:R:L267 S:S:W195 49.175613.67YesYes115
13S:S:W195 S:S:Y190 92.26123.86YesYes154
14S:S:R188 S:S:Y190 93.528812.35YesYes154
15M:M:?1 S:S:R188 90.27724.59YesYes105
16R:R:F199 R:R:Y190 45.95476.19YesYes054
17R:R:F199 R:R:W195 48.05155.01YesYes055
18S:S:L194 S:S:N192 49.50824.12YesNo021
19S:S:N192 S:S:W195 49.39349.04NoYes015
20M:M:?1 S:S:W94 31.189713.77YesYes107
21M:M:?1 S:S:Y116 23.91684.43YesYes106
22M:M:?1 S:S:C186 11.09363.6YesNo109
23M:M:?1 S:S:E288 26.967214.02YesNo105
24L:L:?1 R:R:W94 23.495123.24YesYes307
25R:R:W94 R:R:Y45 25.67414.47YesYes377
26R:R:L41 R:R:Y45 15.07198.21NoYes067
27L:L:?1 R:R:E288 25.398412.02YesYes305
28L:L:?1 R:R:Y116 19.71674.43YesYes306
29R:R:F87 R:R:Y116 14.47278.25NoYes376
30R:R:F87 R:R:N119 14.430515.71NoNo078
31R:R:D84 R:R:N119 13.80956.73YesNo098
32R:R:E288 R:R:Y255 32.22795.61YesYes057
33R:R:W252 R:R:Y255 26.33217.72YesYes097
34R:R:F248 R:R:W252 19.906410.02YesYes1099
35R:R:F248 R:R:V124 19.57583.93YesNo097
36R:R:P211 R:R:V124 19.39637.07NoNo097
37R:R:P211 R:R:W125 19.33824.32NoNo095
38R:R:V160 R:R:W125 19.27073.68NoNo075
39R:R:F129 R:R:V160 19.27267.87YesNo057
40R:R:F129 R:R:Y76 19.35216.19YesYes557
41R:R:D133 R:R:Y76 19.90585.75YesYes587
42R:R:D133 R:R:R148 19.518713.1YesNo586
43L:L:?1 R:R:D97 17.588527.69YesNo005
44R:R:D97 R:R:W102 16.76384.47NoYes059
45R:R:F104 R:R:W102 10.119520.04YesYes479
46R:R:L136 R:R:R148 20.71584.86NoNo056
47R:R:L136 R:R:Y135 20.76583.52NoYes058
48S:S:E288 S:S:Y255 27.646512.35NoYes057
49S:S:F87 S:S:W94 20.05066.01YesYes177
50S:S:F87 S:S:N119 41.268915.71YesNo078
51S:S:D84 S:S:N119 29.04354.04YesNo098
52S:S:C295 S:S:V88 15.90763.42NoNo096
53S:S:I53 S:S:V88 11.93824.61YesNo056
54S:S:F87 S:S:Y116 19.6118.25YesYes176
55S:S:H294 S:S:N119 16.0967.65YesNo098
56S:S:C295 S:S:H294 13.36997.37NoYes099
57S:S:W252 S:S:Y255 20.32817.72YesYes097
58S:S:D84 S:S:N56 17.41236.73YesNo099
59R:R:I221 R:R:Y135 13.13662.42NoYes048
60R:R:I221 R:R:S217 13.09751.55NoNo043
61R:R:I213 R:R:S217 13.09171.55NoNo033
62R:R:I213 S:S:L210 13.10462.85NoNo036
63S:S:L210 S:S:W125 13.16032.28NoYes065
64S:S:V160 S:S:W125 10.18553.68NoYes075
65S:S:F248 S:S:W252 13.04059.02YesYes999
66S:S:P211 S:S:W125 19.705217.57NoYes095
67S:S:F248 S:S:V124 19.99685.24YesNo097
68S:S:P211 S:S:V124 19.76168.84NoNo097
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
M:M:?1 S:S:W94 13.77 1 Yes Yes 0 7 0 1
M:M:?1 S:S:D97 20.51 1 Yes No 0 5 0 1
M:M:?1 S:S:H113 6.8 1 Yes No 0 6 0 1
M:M:?1 S:S:Y116 4.43 1 Yes Yes 0 6 0 1
M:M:?1 S:S:R183 9.18 1 Yes Yes 0 3 0 1
M:M:?1 S:S:C186 3.6 1 Yes No 0 9 0 1
M:M:?1 S:S:D187 4.1 1 Yes No 0 3 0 1
M:M:?1 S:S:R188 4.59 1 Yes Yes 0 5 0 1
M:M:?1 S:S:E288 14.02 1 Yes No 0 5 0 1
S:S:L91 S:S:Y45 3.52 1 No Yes 8 7 2 2
S:S:W94 S:S:Y45 11.58 1 Yes Yes 7 7 1 2
S:S:F87 S:S:T90 3.89 1 Yes No 7 6 2 2
S:S:F87 S:S:L91 7.31 1 Yes No 7 8 2 2
S:S:F87 S:S:W94 6.01 1 Yes Yes 7 7 2 1
S:S:F87 S:S:Y116 8.25 1 Yes Yes 7 6 2 1
S:S:F292 S:S:F87 13.93 1 Yes Yes 7 7 2 2
S:S:T90 S:S:W94 4.85 1 No Yes 6 7 2 1
S:S:L91 S:S:W94 6.83 1 No Yes 8 7 2 1
S:S:W94 S:S:Y116 10.61 1 Yes Yes 7 6 1 1
S:S:F292 S:S:W94 7.02 1 Yes Yes 7 7 2 1
S:S:D97 S:S:R183 4.76 1 No Yes 5 3 1 1
S:S:N101 S:S:R183 3.62 0 No Yes 4 3 2 1
S:S:C109 S:S:W102 3.92 1 No Yes 9 9 2 2
S:S:C186 S:S:W102 18.28 1 No Yes 9 9 1 2
S:S:C109 S:S:C186 7.28 1 No No 9 9 2 1
S:S:A175 S:S:H113 8.78 0 No No 4 6 2 1
S:S:H113 S:S:R188 6.77 1 No Yes 6 5 1 1
S:S:L120 S:S:Y116 17.58 0 No Yes 7 6 2 1
S:S:E288 S:S:Y116 7.86 1 No Yes 5 6 1 1
S:S:F292 S:S:Y116 6.19 1 Yes Yes 7 6 2 1
S:S:D171 S:S:R188 5.96 0 No Yes 4 5 2 1
S:S:I185 S:S:R183 7.52 0 No Yes 3 3 2 1
S:S:D187 S:S:F189 8.36 0 No No 3 3 1 2
S:S:R188 S:S:Y190 12.35 1 Yes Yes 5 4 1 2
S:S:E288 S:S:Y255 12.35 1 No Yes 5 7 1 2
S:S:D182 S:S:R183 2.38 0 No Yes 6 3 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:W94 23.24 3 Yes Yes 0 7 0 1
L:L:?1 R:R:D97 27.69 3 Yes No 0 5 0 1
L:L:?1 R:R:H113 7.77 3 Yes No 0 6 0 1
L:L:?1 R:R:Y116 4.43 3 Yes Yes 0 6 0 1
L:L:?1 R:R:R183 5.51 3 Yes Yes 0 3 0 1
L:L:?1 R:R:D187 4.1 3 Yes No 0 3 0 1
L:L:?1 R:R:R188 4.59 3 Yes Yes 0 5 0 1
L:L:?1 R:R:E288 12.02 3 Yes Yes 0 5 0 1
R:R:W94 R:R:Y45 14.47 3 Yes Yes 7 7 1 2
R:R:F292 R:R:Y45 4.13 3 Yes Yes 7 7 2 2
R:R:F87 R:R:Y116 8.25 3 No Yes 7 6 2 1
R:R:F292 R:R:F87 9.65 3 Yes No 7 7 2 2
R:R:W94 R:R:Y116 8.68 3 Yes Yes 7 6 1 1
R:R:E288 R:R:W94 6.54 3 Yes Yes 5 7 1 1
R:R:F292 R:R:W94 11.02 3 Yes Yes 7 7 2 1
R:R:D97 R:R:W102 4.47 0 No Yes 5 9 1 2
R:R:N101 R:R:R183 3.62 0 No Yes 4 3 2 1
R:R:A175 R:R:H113 5.85 0 No No 4 6 2 1
R:R:H113 R:R:R188 7.9 3 No Yes 6 5 1 1
R:R:L120 R:R:Y116 8.21 0 No Yes 7 6 2 1
R:R:E288 R:R:Y116 7.86 3 Yes Yes 5 6 1 1
R:R:F292 R:R:Y116 8.25 3 Yes Yes 7 6 2 1
R:R:D171 R:R:R188 4.76 0 No Yes 4 5 2 1
R:R:I185 R:R:R183 3.76 0 No Yes 3 3 2 1
R:R:D187 R:R:F189 7.17 0 No No 3 3 1 2
R:R:R188 R:R:Y190 13.38 3 Yes Yes 5 4 1 2
R:R:E288 R:R:Y255 5.61 3 Yes Yes 5 7 1 2
R:R:E288 R:R:F292 5.83 3 Yes Yes 5 7 1 2
R:R:D181 R:R:R183 1.19 0 No Yes 2 3 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 3OE9_poly
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.52
Number of Linked Nodes 480
Number of Links 534
Number of Hubs 67
Number of Links mediated by Hubs 251
Number of Communities 14
Number of Nodes involved in Communities 90
Number of Links involved in Communities 123
Path Summary
Number Of Nodes in MetaPath 69
Number Of Links MetaPath 68
Number of Shortest Paths 261269
Length Of Smallest Path 3
Average Path Length 20.6808
Length of Longest Path 37
Minimum Path Strength 1.38
Average Path Strength 7.00351
Maximum Path Strength 25.465
Minimum Path Correlation 0.7
Average Path Correlation 0.956294
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 4
Average % Of Corr. Nodes 42.2049
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.1797
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• molecular transducer activity   • coreceptor activity   • signaling receptor activity   • cytoskeletal protein binding   • myosin light chain binding   • protein binding   • binding   • myosin binding   • small molecule binding   • C-C chemokine binding   • chemokine binding   • cytokine binding   • G protein-coupled chemoattractant receptor activity   • C-X-C motif chemokine 12 receptor activity   • C-X-C chemokine receptor activity   • chemokine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • cytokine receptor activity   • immune receptor activity   • ubiquitin protein ligase binding   • ubiquitin-like protein ligase binding   • enzyme binding   • virus receptor activity   • exogenous protein binding   • C-C chemokine receptor activity   • ubiquitin binding   • ubiquitin-like protein binding   • actin binding   • hydrolase activity, acting on glycosyl bonds   • peptidoglycan muralytic activity   • hydrolase activity, hydrolyzing O-glycosyl compounds   • lysozyme activity   • hydrolase activity   • catalytic activity   • developmental process   • multicellular organism development   • multicellular organismal process   • head development   • central nervous system development   • anatomical structure development   • animal organ development   • brain development   • nervous system development   • system development   • regulation of biological process   • cell adhesion   • regulation of cellular process   • regulation of cell adhesion
Gene OntologyBiological Process• developmental process   • multicellular organism development   • multicellular organismal process   • head development   • central nervous system development   • anatomical structure development   • animal organ development   • brain development   • nervous system development   • system development   • regulation of biological process   • cell adhesion   • regulation of cellular process   • regulation of cell adhesion   • biological regulation   • cellular process   • neuron recognition   • cellular developmental process   • cell development   • generation of neurons   • neurogenesis   • neuron differentiation   • cell differentiation   • neuron development   • cell recognition   • regulation of calcium ion transport   • regulation of localization   • transport   • regulation of transport   • regulation of monoatomic ion transport   • establishment of localization   • metal ion transport   • calcium ion transport   • localization   • monoatomic ion transport   • regulation of metal ion transport   • monoatomic cation transport   • response to stimulus   • response to mechanical stimulus   • response to abiotic stimulus   • response to external stimulus   • response to ultrasound   • chemotaxis   • positive regulation of locomotion   • regulation of response to external stimulus   • positive regulation of biological process   • regulation of chemotaxis   • positive regulation of chemotaxis   • positive regulation of response to stimulus   • positive regulation of response to external stimulus   • taxis   • regulation of response to stimulus   • response to chemical   • regulation of locomotion   • locomotion   • forebrain development   • telencephalon cell migration   • forebrain cell migration   • cell migration   • telencephalon development   • cell motility   • apoptotic process   • cell death   • programmed cell death   • epithelium development   • endothelium development   • tube development   • morphogenesis of an endothelium   • endothelial tube morphogenesis   • morphogenesis of an epithelium   • tissue development   • tissue morphogenesis   • anatomical structure morphogenesis   • tube morphogenesis   • epithelial tube morphogenesis   • regulation of viral process   • viral process   • membrane organization   • cellular component organization   • myelination   • myelin maintenance   • axon ensheathment   • ensheathment of neurons   • plasma membrane organization   • cellular component organization or biogenesis   • endomembrane system organization   • cell chemotaxis   • cellular response to stimulus   • dendritic cell chemotaxis   • leukocyte migration   • dendritic cell migration   • cellular response to chemical stimulus   • immune system process   • mononuclear cell migration   • leukocyte chemotaxis   • detection of external stimulus   • system process   • detection of stimulus involved in sensory perception of pain   • nervous system process   • sensory perception of temperature stimulus   • sensory perception of pain   • detection of temperature stimulus involved in sensory perception   • response to temperature stimulus   • detection of abiotic stimulus   • detection of stimulus   • sensory perception   • detection of temperature stimulus   • detection of stimulus involved in sensory perception   • detection of temperature stimulus involved in sensory perception of pain   • response to decreased oxygen levels   • response to hypoxia   • response to stress   • response to oxygen levels   • cellular response to xenobiotic stimulus   • response to xenobiotic stimulus   • epithelial cell development   • epithelial cell differentiation   • regulation of growth   • developmental growth   • cell projection organization   • neuron projection development   • regulation of cell morphogenesis   • positive regulation of developmental process   • cell projection morphogenesis   • neuron projection morphogenesis   • positive regulation of developmental growth   • developmental growth involved in morphogenesis   • positive regulation of dendrite extension   • regulation of cellular component organization   • regulation of developmental process   • plasma membrane bounded cell projection morphogenesis   • cell growth   • cell morphogenesis   • dendrite extension   • positive regulation of cellular process   • regulation of anatomical structure morphogenesis   • neuron projection extension   • regulation of developmental growth   • plasma membrane bounded cell projection organization   • developmental cell growth   • growth   • regulation of dendrite extension   • positive regulation of cell growth   • regulation of cell growth   • positive regulation of growth   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • detection of mechanical stimulus involved in sensory perception of pain   • detection of mechanical stimulus involved in sensory perception   • sensory perception of mechanical stimulus   • detection of mechanical stimulus   • immune response   • cell surface receptor signaling pathway   • chemokine (C-X-C motif) ligand 12 signaling pathway   • signaling   • CXCL12-activated CXCR4 signaling pathway   • response to cytokine   • response to chemokine   • cytokine-mediated signaling pathway   • cellular response to chemokine   • chemokine-mediated signaling pathway   • cell communication   • response to peptide   • G protein-coupled receptor signaling pathway   • cellular response to cytokine stimulus   • signal transduction   • C-X-C chemokine receptor CXCR4 signaling pathway   • response to activity   • regulation of cell motility   • positive regulation of mesenchymal stem cell migration   • positive regulation of cell migration   • regulation of mesenchymal stem cell migration   • mesenchymal stem cell migration   • positive regulation of cell motility   • regulation of cell migration   • intracellular signal transduction   • calcium-mediated signaling   • intracellular signaling cassette   • endothelial cell differentiation   • angiogenesis   • regulation of vasculature development   • regulation of response to wounding   • positive regulation of vascular wound healing   • vascular wound healing   • regulation of response to stress   • regulation of multicellular organismal process   • response to wounding   • blood vessel development   • positive regulation of response to wounding   • wound healing   • regulation of multicellular organismal development   • blood vessel morphogenesis   • angiogenesis involved in wound healing   • positive regulation of angiogenesis   • vasculature development   • circulatory system development   • positive regulation of vasculature development   • positive regulation of wound healing   • regulation of angiogenesis   • regulation of wound healing   • anatomical structure formation involved in morphogenesis   • positive regulation of multicellular organismal process   • regulation of vascular wound healing   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • positive regulation of macrophage migration inhibitory factor signaling pathway   • positive regulation of response to cytokine stimulus   • macrophage migration inhibitory factor signaling pathway   • regulation of signaling   • regulation of macrophage migration inhibitory factor signaling pathway   • regulation of cytokine-mediated signaling pathway   • regulation of response to cytokine stimulus   • regulation of cell communication   • positive regulation of cytokine-mediated signaling pathway   • positive regulation of signaling   • homeostatic process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • metabolic process   • regulation of metabolic process   • regulation of programmed cell death   • response to tacrolimus   • response to oxygen-containing compound   • response to nitrogen compound   • heart process   • circulatory system process   • cardiac muscle contraction   • heart contraction   • muscle contraction   • muscle system process   • blood circulation   • striated muscle contraction   • biological process involved in interspecies interaction between organisms   • response to other organism   • response to external biotic stimulus   • response to virus   • response to biotic stimulus   • defense response   • inflammatory response   • neuron migration   • positive regulation of nervous system development   • regulation of neurogenesis   • regulation of cell differentiation   • regulation of gliogenesis   • positive regulation of gliogenesis   • regulation of cell development   • regulation of nervous system development   • gliogenesis   • positive regulation of cell differentiation   • positive regulation of neurogenesis   • positive regulation of oligodendrocyte differentiation   • positive regulation of cell development   • regulation of glial cell differentiation   • positive regulation of glial cell differentiation   • oligodendrocyte differentiation   • glial cell differentiation   • regulation of oligodendrocyte differentiation   • defense response to bacterium   • defense response to other organism   • response to bacterium   • carbohydrate derivative catabolic process   • catabolic process   • peptidoglycan catabolic process   • glycosaminoglycan metabolic process   • carbohydrate derivative metabolic process   • aminoglycan catabolic process   • macromolecule catabolic process   • glycosaminoglycan catabolic process   • aminoglycan metabolic process   • peptidoglycan metabolic process   • macromolecule metabolic process   • symbiont-mediated cytolysis of host cell   • viral life cycle   • disruption of cell in another organism   • cytolysis   • biological process involved in interaction with host   • biological process involved in symbiotic interaction   • viral release from host cell by cytolysis   • exit from host cell   • cytolysis in another organism   • viral release from host cell   • disruption of anatomical structure in another organism   • symbiont-mediated killing of host cell   • killing of cells of another organism   • cell killing   • cell wall organization or biogenesis   • cell wall macromolecule catabolic process   • cell wall macromolecule metabolic process   • cell periphery   • cellular anatomical structure   • cell surface   • membrane   • plasma membrane   • external side of plasma membrane   • side of membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space
Gene OntologyCellular Component• cell periphery   • cellular anatomical structure   • cell surface   • membrane   • plasma membrane   • external side of plasma membrane   • side of membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • cell leading edge   • intracellular anatomical structure   • cytoplasm   • anchoring junction   • cell junction   • intracellular organelle   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • lysosome   • protein-containing complex   • cytoplasmic vesicle   • intracellular vesicle   • early endosome   • endosome   • endomembrane system   • late endosome   • host cellular component   • host intracellular part   • host cell cytoplasm   • host cell part   • host intracellular region
SCOP2Domain Identifier• G protein-coupled receptor-like
SCOP2Family Identifier• G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeITD
PDB ResiduesL:L:?1 M:M:?1
Environment DetailsOpen EMBL-EBI Page
CodeITD
Name(6,6-dimethyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-3-yl)methyl N,N'-dicyclohexylimidothiocarbamate
Synonyms
Identifier
FormulaC21 H34 N4 S2
Molecular Weight406.651
SMILES
PubChem25147749
Formal Charge0
Total Atoms61
Total Chiral Atoms0
Total Bonds64
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP61073
Sequence
>3OE9_poly_Chain_R
CFRNFNKIF LPTIYSIIF LTGIVGNGL VILVMGYQK KLRSMTDKY 
RLHLSVADL LFVITLPFW AVDAVANWY FGNFLCKAV HVIYTVNLY 
SSVWILAFI SLDRYLAIV HATNSQRPR KLLAEKVVY VGVWIPALL 
LTIPDFIFA NVSEADDRY ICDRFYPND LWVVVFQFQ HIMVGLILP 
GIVILSCYC IIISKLSHK ALKPTVILI LAFFACWLP YYIGISIDS 
FILLEIIKC EFENTVHKW ISITEALAF FHCCLNPIL YA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YU7AProteinChemokineCXCR4Homo sapiens---3.012025-03-0510.1016/j.celrep.2025.115255
8YU7 (Multimeric) AProteinChemokineCXCR4Homo sapiens--3.012025-03-0510.1016/j.celrep.2025.115255
8K3ZAProteinChemokineCXCR4Homo sapiensCXCL12-Gi1/β1/γ12.812024-07-17To be published
8K3Z (No Gprot) AProteinChemokineCXCR4Homo sapiensCXCL12-2.812024-07-17To be published
8U4TAProteinChemokineCXCR4Homo sapiensREGN7663-Fab--3.382024-03-13doi.org/10.1038/s41594-024-01397-1
8U4T (Multimeric) AProteinChemokineCXCR4Homo sapiensREGN7663-Fab-3.382024-03-13doi.org/10.1038/s41594-024-01397-1
8U4SAProteinChemokineCXCR4Homo sapiensREGN7663-Fab--3.352024-03-13doi.org/10.1038/s41594-024-01397-1
8U4S (Multimeric) AProteinChemokineCXCR4Homo sapiensREGN7663-Fab-3.352024-03-13doi.org/10.1038/s41594-024-01397-1
8U4RAProteinChemokineCXCR4Homo sapiensREGN7663-FabCholesterol-3.12024-03-1310.1101/2024.02.09.579708
8U4QAProteinChemokineCXCR4Homo sapiensREGN7663-FabCholesterolGi1/β1/γ23.362024-03-1310.1101/2024.02.09.579708
8U4Q (No Gprot) AProteinChemokineCXCR4Homo sapiensREGN7663-FabCholesterol3.362024-03-1310.1101/2024.02.09.579708
8U4PAProteinChemokineCXCR4Homo sapiensAMD3100CholesterolGi1/β1/γ23.152024-03-1310.1101/2024.02.09.579708
8U4P (No Gprot) AProteinChemokineCXCR4Homo sapiensAMD3100Cholesterol3.152024-03-1310.1101/2024.02.09.579708
8U4OAProteinChemokineCXCR4Homo sapiensCXCL12CholesterolGi1/β1/γ23.292024-03-1310.1101/2024.02.09.579708
8U4O (No Gprot) AProteinChemokineCXCR4Homo sapiensCXCL12Cholesterol3.292024-03-1310.1101/2024.02.09.579708
8U4NAProteinChemokineCXCR4Homo sapiens-CholesterolGi1/β1/γ22.722024-03-1310.1101/2024.02.09.579708
8U4N (No Gprot) AProteinChemokineCXCR4Homo sapiens-Cholesterol2.722024-03-1310.1101/2024.02.09.579708
8ZPNAProteinChemokineCXCR4Homo sapiensAMD3100Cholesterol-3.312025-02-26To be published
8ZPMAProteinChemokineCXCR4Homo sapiensAMD070Cholesterol-3.22025-02-26To be published
8ZPLAProteinChemokineCXCR4Homo sapiensHF51116Cholesterol-3.012025-02-26To be published
4RWSAProteinChemokineCXCR4Homo sapiensvMIP-II--3.12015-02-1110.1126/science.1261064
3OE9AProteinChemokineCXCR4Homo sapiensIT1t--3.12010-10-2710.1126/science.1194396
3OE9 (Multimeric) AProteinChemokineCXCR4Homo sapiensIT1t-3.12010-10-2710.1126/science.1194396
3OE8AProteinChemokineCXCR4Homo sapiensIT1t--3.12010-10-2710.1126/science.1194396
3OE8 (Multimeric) AProteinChemokineCXCR4Homo sapiensIT1t-3.12010-10-2710.1126/science.1194396
3OE6AProteinChemokineCXCR4Homo sapiensIT1t--3.22010-10-2710.1126/science.1194396
3OE0AProteinChemokineCXCR4Homo sapiensCVX15--2.92010-10-2710.1126/science.1194396
3ODUAProteinChemokineCXCR4Homo sapiensIT1t--2.52010-10-2710.1126/science.1194396
3ODU (Multimeric) AProteinChemokineCXCR4Homo sapiensIT1t-2.52010-10-2710.1126/science.1194396




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 3OE9_poly.zip



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