psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N31	R:R:T32	4.39	No	No	0	1	4
2	R:R:D37	R:R:L33	4.07	No	No	0	4	4
3	R:R:H99	R:R:L33	7.71	No	No	0	2	4
4	R:R:K280	R:R:R34	11.14	No	No	0	2	2
5	R:R:P36	R:R:V35	3.53	Yes	No	0	3	3
6	R:R:L39	R:R:V35	2.98	No	No	0	5	3
7	R:R:D37	R:R:P36	3.22	No	Yes	0	4	3
8	R:R:L281	R:R:P36	3.28	No	Yes	0	5	3
9	R:R:L284	R:R:P36	3.28	No	Yes	0	4	3
10	R:R:D37	R:R:H100	5.04	No	No	0	4	4
11	R:R:A40	R:R:S287	3.42	No	Yes	0	6	4
12	R:R:F93	R:R:L41	12.18	No	No	2	7	5
13	R:R:I96	R:R:L41	4.28	Yes	No	2	5	5
14	R:R:L41	R:R:V97	2.98	No	No	2	5	3
15	R:R:I43	R:R:S287	12.39	No	Yes	0	5	4
16	R:R:F44	R:R:L89	8.53	Yes	Yes	2	7	7
17	R:R:F44	R:R:I96	3.77	Yes	Yes	2	7	5
18	R:R:F44	R:R:V286	3.93	Yes	No	0	7	5
19	R:R:F44	R:R:S287	5.28	Yes	Yes	0	7	4
20	R:R:F44	R:R:Y290	7.22	Yes	Yes	2	7	7
21	R:R:L89	R:R:V47	2.98	Yes	No	0	7	6
22	R:R:C294	R:R:V47	6.83	No	No	0	7	6
23	R:R:F48	R:R:V52	5.24	Yes	No	0	6	5
24	R:R:F48	R:R:L89	4.87	Yes	Yes	0	6	7
25	R:R:F48	R:R:P90	7.22	Yes	No	0	6	9
26	R:R:C294	R:R:V50	3.42	No	No	0	7	6
27	R:R:I298	R:R:V50	3.07	No	No	0	7	6
28	R:R:F83	R:R:V52	5.24	No	No	0	8	5
29	R:R:G54	R:R:P297	4.06	No	No	0	7	9
30	R:R:A79	R:R:N55	3.13	No	No	0	8	9
31	R:R:D82	R:R:N55	5.39	Yes	No	0	9	9
32	R:R:N55	R:R:P297	6.52	No	No	0	9	9
33	R:R:A79	R:R:V58	3.39	No	No	0	8	8
34	R:R:V58	R:R:Y300	3.79	No	Yes	9	8	9
35	R:R:L323	R:R:V58	4.47	Yes	No	9	5	8
36	R:R:L76	R:R:V59	4.47	No	No	0	6	7
37	R:R:F64	R:R:W60	14.03	No	No	0	4	4
38	R:R:L319	R:R:V61	4.47	No	No	0	5	6
39	R:R:R320	R:R:V61	6.54	No	No	0	6	6
40	R:R:A72	R:R:T62	3.36	No	No	0	7	6
41	R:R:L76	R:R:T62	5.9	No	No	0	6	6
42	R:R:E65	R:R:T324	14.11	No	No	0	5	5
43	R:R:I70	R:R:W74	8.22	Yes	Yes	3	6	7
44	R:R:I70	R:R:R148	13.78	Yes	Yes	3	6	7
45	R:R:A153	R:R:I70	3.25	No	Yes	3	7	6
46	R:R:N71	R:R:R134	3.62	Yes	Yes	3	7	9
47	R:R:N71	R:R:R148	4.82	Yes	Yes	3	7	7
48	R:R:N71	R:R:T240	5.85	Yes	No	3	7	7
49	R:R:N71	R:R:S327	5.96	Yes	Yes	3	7	4
50	R:R:I73	R:R:W154	21.14	No	No	0	6	3
51	R:R:T129	R:R:W74	4.85	No	Yes	0	6	7
52	R:R:I130	R:R:W74	12.92	No	Yes	0	8	7
53	R:R:D133	R:R:W74	11.17	No	Yes	3	8	7
54	R:R:A153	R:R:W74	3.89	No	Yes	3	7	7
55	R:R:F75	R:R:Y300	7.22	No	Yes	9	8	9
56	R:R:F75	R:R:L323	15.83	No	Yes	9	8	5
57	R:R:L126	R:R:N77	6.87	Yes	Yes	13	7	9
58	R:R:N77	R:R:W154	5.65	Yes	No	0	9	3
59	R:R:C157	R:R:N77	11.02	No	Yes	13	6	9
60	R:R:N77	R:R:W161	5.65	Yes	Yes	0	9	9
61	R:R:L126	R:R:L78	4.15	Yes	No	0	7	9
62	R:R:L127	R:R:L78	4.15	No	No	0	8	9
63	R:R:L84	R:R:V80	2.98	No	No	0	6	5
64	R:R:V80	R:R:W161	3.68	No	Yes	0	5	9
65	R:R:D82	R:R:N119	6.73	Yes	Yes	2	9	9
66	R:R:C293	R:R:D82	6.22	No	Yes	2	8	9
67	R:R:D82	R:R:N296	6.73	Yes	No	0	9	9
68	R:R:F83	R:R:L87	4.87	No	No	0	8	4
69	R:R:A85	R:R:N119	4.69	No	Yes	0	6	9
70	R:R:A85	R:R:Y290	4	No	Yes	0	6	7
71	R:R:A88	R:R:L112	4.73	No	No	0	6	5
72	R:R:A88	R:R:L115	4.73	No	No	0	6	5
73	R:R:L89	R:R:Y290	11.72	Yes	Yes	2	7	7
74	R:R:A91	R:R:F104	5.55	No	No	0	6	7
75	R:R:L92	R:R:Y290	3.52	No	Yes	0	6	7
76	R:R:F93	R:R:V97	3.93	No	No	2	7	3
77	R:R:S95	R:R:W102	4.94	No	Yes	0	4	8
78	R:R:H100	R:R:I96	3.98	No	Yes	2	4	5
79	R:R:I96	R:R:S283	4.64	Yes	No	2	5	4
80	R:R:H101	R:R:Q98	6.18	Yes	No	15	4	4
81	R:R:P103	R:R:Q98	3.16	No	No	15	3	4
82	R:R:H100	R:R:S283	5.58	No	No	2	4	4
83	R:R:H101	R:R:P103	6.1	Yes	No	15	4	3
84	R:R:H101	R:R:K185	5.24	Yes	No	0	4	3
85	R:R:H101	R:R:V186	5.54	Yes	No	0	4	6
86	R:R:F104	R:R:W102	18.04	No	Yes	0	7	8
87	R:R:C109	R:R:W102	3.92	No	Yes	14	9	8
88	R:R:C188	R:R:W102	5.22	No	Yes	14	9	8
89	R:R:F104	R:R:P103	13	No	No	0	7	3
90	R:R:A108	R:R:L112	3.15	No	No	0	5	5
91	R:R:C109	R:R:V177	3.42	No	No	0	9	4
92	R:R:C109	R:R:C188	7.28	No	No	14	9	9
93	R:R:P113	R:R:R175	8.65	No	No	0	6	5
94	R:R:L117	R:R:S114	3	No	No	0	4	5
95	R:R:A172	R:R:S114	3.42	No	No	0	4	5
96	R:R:I116	R:R:N119	4.25	No	Yes	0	6	9
97	R:R:I116	R:R:Y290	18.13	No	Yes	0	6	7
98	R:R:L117	R:R:S171	3	No	No	0	4	5
99	R:R:L118	R:R:L165	4.15	No	No	0	5	4
100	R:R:L118	R:R:T168	8.84	No	No	0	5	6
101	R:R:N119	R:R:S123	4.47	Yes	No	0	9	9
102	R:R:C293	R:R:N119	4.72	No	Yes	2	8	9
103	R:R:M120	R:R:Y121	8.38	No	No	0	7	7
104	R:R:M120	R:R:W255	16.29	No	Yes	0	7	9
105	R:R:L167	R:R:Y121	12.89	No	No	0	4	7
106	R:R:A122	R:R:W161	3.89	No	Yes	0	6	9
107	R:R:I124	R:R:P214	5.08	No	No	0	8	9
108	R:R:F251	R:R:I124	15.07	No	No	0	9	8
109	R:R:L125	R:R:L163	5.54	No	No	1	6	4
110	R:R:L125	W:W:?1	8.24	No	Yes	1	6	0
111	R:R:C157	R:R:L126	3.17	No	Yes	13	6	7
112	R:R:A160	R:R:L126	3.15	No	Yes	0	6	7
113	R:R:L127	R:R:V247	2.98	No	Yes	0	8	7
114	R:R:L127	R:R:V248	4.47	No	No	0	8	7
115	R:R:A128	W:W:?1	9.38	No	Yes	0	7	0
116	R:R:T129	W:W:?1	5.85	No	Yes	0	6	0
117	R:R:I130	R:R:V244	3.07	No	No	0	8	7
118	R:R:L218	R:R:S131	3	No	No	0	8	9
119	R:R:S131	R:R:Y222	8.9	No	Yes	0	9	8
120	R:R:D133	R:R:L137	5.43	No	Yes	3	8	8
121	R:R:D133	R:R:R148	16.68	No	Yes	3	8	7
122	R:R:L137	R:R:R134	6.07	Yes	Yes	3	8	9
123	R:R:R134	R:R:T238	3.88	Yes	No	0	9	5
124	R:R:R134	R:R:T240	7.76	Yes	No	3	9	7
125	R:R:L241	R:R:R134	4.86	No	Yes	0	6	9
126	R:R:R134	R:R:S327	5.27	Yes	Yes	3	9	4
127	R:R:F135	R:R:F139	16.08	No	Yes	0	8	7
128	R:R:F135	R:R:I225	5.02	No	No	0	8	8
129	R:R:L136	R:R:W143	3.42	No	No	0	5	5
130	R:R:C144	R:R:L137	6.35	No	Yes	0	5	8
131	R:R:L137	R:R:R148	7.29	Yes	Yes	3	8	7
132	R:R:L137	R:R:S327	6.01	Yes	Yes	3	8	4
133	R:R:F139	R:R:V138	10.49	Yes	No	0	7	8
134	R:R:F139	R:R:R228	11.76	Yes	No	0	7	5
135	R:R:F147	R:R:W143	20.04	Yes	No	8	4	5
136	R:R:W143	S:S:F147	4.01	No	Yes	8	5	4
137	R:R:Q145	R:R:V328	4.3	No	No	0	5	4
138	R:R:F147	R:R:R146	9.62	Yes	No	8	4	5
139	R:R:R146	S:S:W143	13.99	No	No	8	5	5
140	R:R:R146	S:S:F147	3.21	No	Yes	8	5	4
141	R:R:F147	S:S:W143	9.02	Yes	No	8	4	5
142	R:R:F147	S:S:F147	11.79	Yes	Yes	8	4	4
143	R:R:R148	R:R:S327	7.91	Yes	Yes	3	7	4
144	R:R:L152	R:R:L156	4.15	No	No	0	3	5
145	R:R:L156	W:W:?1	3.66	No	Yes	0	5	0
146	R:R:V159	W:W:?1	9.86	No	Yes	0	1	0
147	R:R:V159	X:X:?1	10.84	No	Yes	0	1	0
148	R:R:L163	S:S:L166	4.15	No	No	1	4	4
149	R:R:L163	W:W:?1	3.66	No	Yes	1	4	0
150	R:R:L166	S:S:V205	2.98	No	No	0	4	3
151	R:R:I169	R:R:P170	3.39	No	No	0	3	8
152	R:R:L173	S:S:R197	3.64	No	No	11	4	1
153	R:R:L173	S:S:R198	10.93	No	Yes	11	4	3
154	R:R:D191	R:R:Y174	3.45	No	Yes	0	4	4
155	R:R:Y174	S:S:Y174	7.94	Yes	No	0	4	4
156	R:R:Y174	S:S:R198	17.49	Yes	Yes	0	4	3
157	R:R:C188	R:R:R175	4.18	No	No	0	9	5
158	R:R:G189	R:R:R175	3	No	No	0	4	5
159	R:R:E179	R:R:Y181	12.35	No	No	0	2	1
160	R:R:E180	R:R:L187	5.3	No	No	0	1	4
161	R:R:F182	R:R:Y181	6.19	No	No	0	3	1
162	R:R:E199	R:R:H194	14.77	No	No	0	4	1
163	R:R:D195	R:R:R197	4.76	No	No	0	3	1
164	R:R:D195	R:R:R198	7.15	No	No	0	3	3
165	R:R:R198	S:S:S110	3.95	No	No	0	3	6
166	R:R:R198	S:S:V176	5.23	No	No	0	3	4
167	R:R:F267	R:R:R200	16.03	No	No	0	4	3
168	R:R:R206	R:R:V202	6.54	No	No	0	6	5
169	R:R:V202	S:S:L173	2.98	No	Yes	0	5	4
170	R:R:A203	R:R:S266	3.42	No	No	0	5	5
171	R:R:F267	R:R:I204	5.02	No	No	0	4	3
172	R:R:L209	R:R:V205	2.98	No	No	0	4	3
173	R:R:V205	S:S:I169	3.07	No	No	0	3	3
174	R:R:V205	S:S:L173	2.98	No	Yes	0	3	4
175	R:R:L207	R:R:L212	6.92	No	No	0	5	4
176	R:R:L207	R:R:Q259	6.65	No	No	0	5	8
177	R:R:I263	R:R:L207	5.71	No	No	0	5	5
178	R:R:L209	S:S:L166	4.15	No	No	1	4	4
179	R:R:L209	W:W:?1	3.66	No	Yes	1	4	0
180	R:R:F211	R:R:L212	3.65	Yes	No	0	8	4
181	R:R:F211	R:R:F252	6.43	Yes	No	0	8	5
182	R:R:F211	R:R:L256	6.09	Yes	No	0	8	5
183	R:R:F211	R:R:Q259	5.86	Yes	No	0	8	8
184	R:R:P214	R:R:W213	4.05	No	No	1	9	5
185	R:R:T217	R:R:W213	10.92	No	No	1	5	5
186	R:R:W213	W:W:?1	19.59	No	Yes	1	5	0
187	R:R:P214	W:W:?1	5.43	No	Yes	1	9	0
188	R:R:F252	R:R:L215	14.61	No	No	0	5	5
189	R:R:I220	R:R:L216	4.28	No	No	0	3	2
190	R:R:T217	W:W:?1	4.88	No	Yes	1	5	0
191	R:R:L218	R:R:V248	2.98	No	No	0	8	7
192	R:R:C221	R:R:Y222	4.03	No	Yes	0	6	8
193	R:R:I225	R:R:Y222	3.63	No	Yes	0	8	8
194	R:R:V244	R:R:Y222	3.79	No	Yes	0	7	8
195	R:R:V245	R:R:Y222	3.79	No	Yes	0	4	8
196	R:R:R228	R:R:T235	3.88	No	No	0	5	4
197	R:R:T229	R:R:T235	3.14	No	No	0	8	4
198	R:R:S237	R:R:T229	3.2	No	No	0	7	8
199	R:R:S231	R:R:W230	3.71	No	No	0	4	4
200	R:R:A232	R:R:T235	3.36	No	No	0	5	4
201	R:R:L241	R:R:S237	4.5	No	No	0	6	7
202	R:R:K242	R:R:S237	6.12	No	No	0	6	7
203	R:R:E325	R:R:T238	9.88	No	No	0	8	5
204	R:R:F307	R:R:K239	21.09	No	No	0	9	7
205	R:R:E325	R:R:K239	4.05	No	No	0	8	7
206	R:R:E325	R:R:T240	9.88	No	No	0	8	7
207	R:R:L241	R:R:V245	2.98	No	No	0	6	4
208	R:R:A246	R:R:I299	3.25	No	Yes	0	5	7
209	R:R:S250	R:R:V247	3.23	Yes	Yes	10	6	7
210	R:R:N296	R:R:V247	8.87	No	Yes	0	9	7
211	R:R:I299	R:R:V247	3.07	Yes	Yes	10	7	7
212	R:R:N292	R:R:S250	2.98	No	Yes	0	9	6
213	R:R:I295	R:R:S250	4.64	No	Yes	10	7	6
214	R:R:I299	R:R:S250	3.1	Yes	Yes	10	7	6
215	R:R:F251	R:R:F252	8.57	No	No	0	9	5
216	R:R:F251	R:R:W255	10.02	No	Yes	0	9	9
217	R:R:F254	R:R:I253	3.77	Yes	No	0	8	5
218	R:R:F254	R:R:F288	12.86	Yes	No	0	8	8
219	R:R:F254	R:R:I291	20.09	Yes	No	0	8	5
220	R:R:F254	R:R:N292	8.46	Yes	No	0	8	9
221	R:R:F254	R:R:I295	7.54	Yes	No	0	8	7
222	R:R:W255	R:R:Y258	7.72	Yes	No	0	9	7
223	R:R:A289	R:R:W255	7.78	No	Yes	0	8	9
224	R:R:N292	R:R:W255	7.91	No	Yes	0	9	9
225	R:R:L256	R:R:P257	3.28	No	No	0	5	9
226	R:R:L256	R:R:V260	2.98	No	No	0	5	6
227	R:R:F288	R:R:P257	7.22	No	No	0	8	9
228	R:R:M264	R:R:V260	4.56	No	No	0	4	6
229	R:R:C285	R:R:T261	6.76	No	No	0	6	4
230	R:R:F267	R:R:I263	5.02	No	No	0	4	5
231	R:R:L278	R:R:M264	5.65	No	No	0	4	4
232	R:R:F275	R:R:M265	4.98	Yes	No	0	3	4
233	R:R:L278	R:R:M265	5.65	No	No	0	4	4
234	R:R:L268	R:R:T274	4.42	No	No	0	2	1
235	R:R:F275	R:R:L268	3.65	Yes	No	0	3	2
236	R:R:E269	R:R:P270	3.14	No	No	0	3	3
237	R:R:E269	R:R:S271	4.31	No	No	0	3	4
238	R:R:F275	R:R:P270	5.78	Yes	No	0	3	3
239	R:R:P273	R:R:S272	3.56	No	No	0	2	4
240	R:R:S272	R:R:T274	4.8	No	No	0	4	1
241	R:R:K280	R:R:L276	7.05	No	No	0	2	3
242	R:R:L277	R:R:L281	4.15	No	No	0	1	5
243	R:R:D282	R:R:V286	4.38	No	No	0	4	5
244	R:R:L284	R:R:S287	4.5	No	Yes	0	4	4
245	R:R:C293	R:R:Y290	4.03	No	Yes	2	8	7
246	R:R:I295	R:R:I299	7.36	No	Yes	10	7	7
247	R:R:N296	R:R:Y300	9.3	No	Yes	0	9	9
248	R:R:L323	R:R:Y300	14.07	Yes	Yes	9	5	9
249	R:R:L315	R:R:V301	2.98	No	No	0	6	6
250	R:R:G304	R:R:L318	5.13	No	No	0	8	3
251	R:R:E317	R:R:K313	5.4	No	No	0	3	4
252	R:R:P316	R:R:S314	5.34	No	No	0	5	4
253	R:R:E317	R:R:S314	5.75	No	No	0	3	4
254	R:R:L315	R:R:P316	3.28	No	No	0	6	5
255	R:R:L323	R:R:V322	5.96	Yes	No	0	5	5
256	R:R:R330	R:R:V328	7.85	No	No	0	5	4
257	S:S:H99	S:S:L33	3.86	No	No	0	2	4
258	S:S:D37	S:S:R34	4.76	No	No	0	4	2
259	S:S:K280	S:S:R34	9.9	No	No	0	2	2
260	S:S:P36	S:S:V35	3.53	Yes	No	0	3	3
261	S:S:D37	S:S:P36	3.22	No	Yes	0	4	3
262	S:S:L281	S:S:P36	3.28	No	Yes	0	5	3
263	S:S:L284	S:S:P36	3.28	No	Yes	0	4	3
264	S:S:L284	S:S:L39	4.15	No	No	0	4	5
265	S:S:A40	S:S:S287	3.42	No	No	0	6	4
266	S:S:F93	S:S:L41	13.4	No	Yes	16	7	5
267	S:S:I96	S:S:L41	8.56	No	Yes	0	5	5
268	S:S:L41	S:S:V97	2.98	Yes	No	16	5	3
269	S:S:I43	S:S:S287	10.84	No	No	0	5	4
270	S:S:F44	S:S:L89	4.87	Yes	Yes	5	7	7
271	S:S:F44	S:S:S287	9.25	Yes	No	0	7	4
272	S:S:F44	S:S:Y290	5.16	Yes	Yes	5	7	7
273	S:S:C294	S:S:V47	8.54	No	No	0	7	6
274	S:S:F48	S:S:V52	7.87	Yes	No	0	6	5
275	S:S:F48	S:S:L89	9.74	Yes	Yes	0	6	7
276	S:S:F48	S:S:P90	8.67	Yes	No	0	6	9
277	S:S:C294	S:S:V50	3.42	No	No	0	7	6
278	S:S:G51	S:S:N55	3.39	No	No	0	8	9
279	S:S:G54	S:S:P297	4.06	No	No	0	7	9
280	S:S:D82	S:S:N55	8.08	Yes	No	0	9	9
281	S:S:N55	S:S:P297	4.89	No	No	0	9	9
282	S:S:L319	S:S:L57	4.15	No	No	0	5	5
283	S:S:T62	S:S:V58	3.17	No	Yes	0	6	8
284	S:S:A79	S:S:V58	3.39	No	Yes	0	8	8
285	S:S:V58	S:S:Y300	3.79	Yes	Yes	12	8	9
286	S:S:L323	S:S:V58	4.47	Yes	Yes	12	5	8
287	S:S:L76	S:S:V59	4.47	No	No	0	6	7
288	S:S:F64	S:S:W60	8.02	No	No	0	4	4
289	S:S:L319	S:S:V61	2.98	No	No	0	5	6
290	S:S:L76	S:S:T62	5.9	No	No	0	6	6
291	S:S:E65	S:S:R320	5.82	No	No	0	5	6
292	S:S:E65	S:S:T324	12.7	No	No	0	5	5
293	S:S:A72	S:S:T69	3.36	No	No	0	7	7
294	S:S:T324	S:S:T69	4.71	No	No	0	5	7
295	S:S:I70	S:S:W74	8.22	Yes	Yes	0	6	7
296	S:S:I70	S:S:R148	15.03	Yes	Yes	0	6	7
297	S:S:N71	S:S:W74	3.39	Yes	Yes	0	7	7
298	S:S:N71	S:S:R134	3.62	Yes	Yes	4	7	9
299	S:S:N71	S:S:R148	3.62	Yes	Yes	4	7	7
300	S:S:N71	S:S:T240	7.31	Yes	No	4	7	7
301	S:S:N71	S:S:S327	5.96	Yes	Yes	4	7	4
302	S:S:A153	S:S:I73	3.25	No	Yes	0	7	6
303	S:S:I73	S:S:W154	17.62	Yes	No	0	6	3
304	S:S:T129	S:S:W74	3.64	No	Yes	0	6	7
305	S:S:I130	S:S:W74	15.27	No	Yes	0	8	7
306	S:S:D133	S:S:W74	11.17	No	Yes	0	8	7
307	S:S:A153	S:S:W74	3.89	No	Yes	0	7	7
308	S:S:F75	S:S:Y300	8.25	No	Yes	12	8	9
309	S:S:F75	S:S:L323	15.83	No	Yes	12	8	5
310	S:S:L126	S:S:N77	6.87	No	Yes	17	7	9
311	S:S:N77	S:S:W154	5.65	Yes	No	0	9	3
312	S:S:C157	S:S:N77	11.02	No	Yes	17	6	9
313	S:S:N77	S:S:W161	5.65	Yes	Yes	0	9	9
314	S:S:L127	S:S:L78	4.15	No	No	0	8	9
315	S:S:L84	S:S:V80	2.98	No	No	0	6	5
316	S:S:V80	S:S:W161	3.68	No	Yes	0	5	9
317	S:S:D82	S:S:N119	6.73	Yes	No	5	9	9
318	S:S:C293	S:S:D82	6.22	No	Yes	5	8	9
319	S:S:D82	S:S:N296	5.39	Yes	No	0	9	9
320	S:S:F83	S:S:L87	6.09	No	No	0	8	4
321	S:S:A85	S:S:N119	4.69	No	No	0	6	9
322	S:S:A85	S:S:Y290	4	No	Yes	0	6	7
323	S:S:C86	S:S:L89	3.17	No	Yes	0	5	7
324	S:S:A88	S:S:L112	3.15	No	No	0	6	5
325	S:S:A88	S:S:L115	4.73	No	No	0	6	5
326	S:S:L89	S:S:Y290	15.24	Yes	Yes	5	7	7
327	S:S:A91	S:S:F104	4.16	No	Yes	0	6	7
328	S:S:L92	S:S:Y290	3.52	No	Yes	0	6	7
329	S:S:F93	S:S:V97	3.93	No	No	16	7	3
330	S:S:Q98	S:S:T94	4.25	No	No	0	4	3
331	S:S:F104	S:S:T94	6.49	Yes	No	0	7	3
332	S:S:S95	S:S:W102	4.94	No	Yes	0	4	8
333	S:S:I96	S:S:S283	6.19	No	No	0	5	4
334	S:S:H101	S:S:Q98	6.18	Yes	No	18	4	4
335	S:S:P103	S:S:Q98	3.16	No	No	18	3	4
336	S:S:H100	S:S:S283	4.18	No	No	0	4	4
337	S:S:H101	S:S:P103	6.1	Yes	No	18	4	3
338	S:S:H101	S:S:K185	3.93	Yes	No	0	4	3
339	S:S:H101	S:S:V186	8.3	Yes	No	0	4	6
340	S:S:F104	S:S:W102	16.04	Yes	Yes	0	7	8
341	S:S:C109	S:S:W102	3.92	Yes	Yes	6	9	8
342	S:S:L112	S:S:W102	3.42	No	Yes	0	5	8
343	S:S:P113	S:S:W102	4.05	No	Yes	0	6	8
344	S:S:C188	S:S:W102	15.67	No	Yes	6	9	8
345	S:S:F104	S:S:P103	10.11	Yes	No	0	7	3
346	S:S:A108	S:S:L112	3.15	No	No	0	5	5
347	S:S:C109	S:S:R175	4.18	Yes	Yes	6	9	5
348	S:S:C109	S:S:V177	3.42	Yes	No	0	9	4
349	S:S:C109	S:S:C188	7.28	Yes	No	6	9	9
350	S:S:P113	S:S:R175	12.97	No	Yes	0	6	5
351	S:S:S114	S:S:T168	3.2	Yes	No	0	5	6
352	S:S:S114	S:S:S171	3.26	Yes	No	6	5	5
353	S:S:R175	S:S:S114	6.59	Yes	Yes	6	5	5
354	S:S:I116	S:S:W255	4.7	No	Yes	0	6	9
355	S:S:I116	S:S:Y290	13.3	No	Yes	0	6	7
356	S:S:L117	S:S:S171	4.5	No	No	0	4	5
357	S:S:L117	S:S:R206	7.29	No	No	0	4	6
358	S:S:L118	S:S:L165	5.54	No	No	0	5	4
359	S:S:L118	S:S:T168	7.37	No	No	0	5	6
360	S:S:C293	S:S:N119	4.72	No	No	5	8	9
361	S:S:G210	S:S:M120	3.49	No	No	0	6	7
362	S:S:M120	S:S:W255	11.63	No	Yes	0	7	9
363	S:S:M120	S:S:Q259	4.08	No	Yes	0	7	8
364	S:S:L167	S:S:Y121	11.72	No	No	0	4	7
365	S:S:A122	S:S:W161	3.89	No	Yes	0	6	9
366	S:S:I124	S:S:P214	6.77	No	No	0	8	9
367	S:S:F251	S:S:I124	15.07	Yes	No	0	9	8
368	S:S:A160	S:S:L125	3.15	No	No	0	6	6
369	S:S:L125	S:S:L163	5.54	No	Yes	1	6	4
370	S:S:L125	X:X:?1	7.33	No	Yes	1	6	0
371	S:S:C157	S:S:L126	3.17	No	No	17	6	7
372	S:S:A160	S:S:L126	3.15	No	No	0	6	7
373	S:S:L127	S:S:V247	2.98	No	No	0	8	7
374	S:S:L127	S:S:V248	2.98	No	No	0	8	7
375	S:S:A128	X:X:?1	9.38	No	Yes	0	7	0
376	S:S:L156	S:S:T129	4.42	No	No	1	5	6
377	S:S:T129	X:X:?1	6.83	No	Yes	1	6	0
378	S:S:I130	S:S:V244	4.61	No	No	0	8	7
379	S:S:L218	S:S:S131	3	No	No	0	8	9
380	S:S:S131	S:S:Y222	7.63	No	Yes	0	9	8
381	S:S:D133	S:S:L137	5.43	No	Yes	4	8	8
382	S:S:D133	S:S:R148	13.1	No	Yes	4	8	7
383	S:S:L137	S:S:R134	4.86	Yes	Yes	4	8	9
384	S:S:R134	S:S:T238	3.88	Yes	No	0	9	5
385	S:S:R134	S:S:T240	10.35	Yes	No	4	9	7
386	S:S:R134	S:S:S327	5.27	Yes	Yes	4	9	4
387	S:S:F135	S:S:F139	16.08	No	No	0	8	7
388	S:S:C221	S:S:F135	4.19	No	No	19	6	8
389	S:S:F135	S:S:I225	5.02	No	No	19	8	8
390	S:S:C144	S:S:L137	4.76	No	Yes	4	5	8
391	S:S:L137	S:S:R148	12.15	Yes	Yes	4	8	7
392	S:S:L137	S:S:S327	6.01	Yes	Yes	4	8	4
393	S:S:F139	S:S:V138	10.49	No	No	0	7	8
394	S:S:F139	S:S:R228	11.76	No	No	0	7	5
395	S:S:K140	S:S:W143	16.24	No	No	0	6	5
396	S:S:C144	S:S:R148	4.18	No	Yes	4	5	7
397	S:S:Q145	S:S:V328	4.3	No	No	0	5	4
398	S:S:F147	S:S:R146	13.9	Yes	No	0	4	5
399	S:S:R148	S:S:S327	7.91	Yes	Yes	4	7	4
400	S:S:L152	S:S:L156	5.54	No	No	0	3	5
401	S:S:L156	X:X:?1	5.5	No	Yes	1	5	0
402	S:S:V159	X:X:?1	9.86	No	Yes	0	1	0
403	S:S:G162	W:W:?1	4.53	No	Yes	0	4	0
404	S:S:L163	S:S:L167	4.15	Yes	No	0	4	4
405	S:S:L163	W:W:?1	3.66	Yes	Yes	1	4	0
406	S:S:L163	X:X:?1	4.58	Yes	Yes	1	4	0
407	S:S:L166	W:W:?1	9.16	No	Yes	1	4	0
408	S:S:I169	S:S:P170	3.39	No	No	0	3	8
409	S:S:R175	S:S:S171	3.95	Yes	No	6	5	5
410	S:S:L173	S:S:Y174	3.52	Yes	No	0	4	4
411	S:S:Y174	S:S:Y192	12.91	No	Yes	0	4	5
412	S:S:G189	S:S:R175	3	No	Yes	0	4	5
413	S:S:D191	S:S:V176	5.84	No	No	0	4	4
414	S:S:E180	S:S:R178	8.14	No	No	20	1	2
415	S:S:L187	S:S:R178	10.93	No	No	20	4	2
416	S:S:E179	S:S:Y181	16.83	No	No	0	2	1
417	S:S:E180	S:S:L187	3.98	No	No	20	1	4
418	S:S:F182	S:S:Y181	4.13	No	No	0	3	1
419	S:S:E199	S:S:V190	5.7	No	No	0	4	5
420	S:S:R198	S:S:Y192	8.23	Yes	Yes	0	3	5
421	S:S:E199	S:S:Y192	10.1	No	Yes	0	4	5
422	S:S:H194	S:S:R197	6.77	No	No	11	1	1
423	S:S:H194	S:S:R198	22.57	No	Yes	11	1	3
424	S:S:R197	S:S:R198	3.2	No	Yes	11	1	3
425	S:S:F267	S:S:R200	7.48	No	No	0	4	3
426	S:S:A203	S:S:S266	3.42	No	No	0	5	5
427	S:S:L209	S:S:V205	2.98	No	No	0	4	3
428	S:S:R206	S:S:Y258	5.14	No	No	0	6	7
429	S:S:Q259	S:S:R206	4.67	Yes	No	0	8	6
430	S:S:L207	S:S:L212	6.92	No	No	0	5	4
431	S:S:L207	S:S:Q259	9.32	No	Yes	0	5	8
432	S:S:I263	S:S:L207	8.56	No	No	0	5	5
433	S:S:L209	X:X:?1	8.24	No	Yes	0	4	0
434	S:S:F211	S:S:F252	7.5	No	No	0	8	5
435	S:S:F211	S:S:L256	4.87	No	No	0	8	5
436	S:S:F211	S:S:Q259	8.2	No	Yes	0	8	8
437	S:S:P214	S:S:W213	4.05	No	Yes	1	9	5
438	S:S:T217	S:S:W213	10.92	No	Yes	1	5	5
439	S:S:W213	X:X:?1	21.86	Yes	Yes	1	5	0
440	S:S:P214	X:X:?1	7.61	No	Yes	1	9	0
441	S:S:F252	S:S:L215	10.96	No	No	0	5	5
442	S:S:T217	X:X:?1	4.88	No	Yes	1	5	0
443	S:S:C221	S:S:Y222	4.03	No	Yes	0	6	8
444	S:S:C221	S:S:I225	3.27	No	No	19	6	8
445	S:S:V244	S:S:Y222	3.79	No	Yes	0	7	8
446	S:S:V248	S:S:Y222	3.79	No	Yes	0	7	8
447	S:S:R228	S:S:T235	3.88	No	No	0	5	4
448	S:S:S237	S:S:T229	3.2	No	No	0	7	8
449	S:S:L241	S:S:S237	6.01	Yes	No	0	6	7
450	S:S:K242	S:S:S237	9.18	No	No	0	6	7
451	S:S:E325	S:S:T238	9.88	No	No	0	8	5
452	S:S:E325	S:S:T240	9.88	No	No	0	8	7
453	S:S:L241	S:S:V245	2.98	Yes	No	0	6	4
454	S:S:A246	S:S:I299	3.25	No	No	0	5	7
455	S:S:N296	S:S:V247	8.87	No	No	0	9	7
456	S:S:I295	S:S:S250	4.64	No	No	0	7	6
457	S:S:I299	S:S:S250	3.1	No	No	0	7	6
458	S:S:F251	S:S:F252	9.65	Yes	No	0	9	5
459	S:S:F251	S:S:W255	11.02	Yes	Yes	7	9	9
460	S:S:F251	S:S:N292	3.62	Yes	No	7	9	9
461	S:S:F254	S:S:F288	11.79	Yes	No	7	8	8
462	S:S:F254	S:S:I291	20.09	Yes	No	7	8	5
463	S:S:F254	S:S:N292	6.04	Yes	No	7	8	9
464	S:S:F254	S:S:I295	5.02	Yes	No	0	8	7
465	S:S:W255	S:S:Y258	5.79	Yes	No	0	9	7
466	S:S:A289	S:S:W255	5.19	No	Yes	0	8	9
467	S:S:N292	S:S:W255	10.17	No	Yes	7	9	9
468	S:S:L256	S:S:P257	3.28	No	No	0	5	9
469	S:S:L256	S:S:V260	2.98	No	No	0	5	6
470	S:S:F288	S:S:P257	8.67	No	No	0	8	9
471	S:S:M264	S:S:V260	4.56	No	No	0	4	6
472	S:S:G262	S:S:T261	3.64	No	No	0	5	4
473	S:S:C285	S:S:T261	6.76	No	No	0	6	4
474	S:S:L278	S:S:M264	4.24	Yes	No	0	4	4
475	S:S:F275	S:S:M265	4.98	Yes	No	0	3	4
476	S:S:L278	S:S:M265	4.24	Yes	No	0	4	4
477	S:S:L268	S:S:S272	3	No	Yes	21	2	4
478	S:S:F275	S:S:L268	3.65	Yes	No	21	3	2
479	S:S:E269	S:S:P270	3.14	No	No	0	3	3
480	S:S:F275	S:S:S272	3.96	Yes	Yes	21	3	4
481	S:S:K280	S:S:L276	8.46	No	No	0	2	3
482	S:S:L277	S:S:L281	4.15	No	No	0	1	5
483	S:S:D282	S:S:V286	4.38	No	No	0	4	5
484	S:S:F288	S:S:I291	3.77	No	No	7	8	5
485	S:S:C293	S:S:Y290	4.03	No	Yes	5	8	7
486	S:S:N296	S:S:Y300	9.3	No	Yes	0	9	9
487	S:S:L323	S:S:Y300	14.07	Yes	Yes	12	5	9
488	S:S:L315	S:S:V301	2.98	No	No	0	6	6
489	S:S:G304	S:S:L318	5.13	No	No	0	8	3
490	S:S:L318	S:S:Q305	3.99	No	No	0	3	6
491	S:S:E317	S:S:K313	17.55	No	No	0	3	4
492	S:S:E321	S:S:K313	12.15	No	No	0	6	4
493	S:S:P316	S:S:S314	7.13	No	No	0	5	4
494	S:S:L315	S:S:P316	3.28	No	No	0	6	5
495	S:S:L323	S:S:V322	4.47	Yes	No	0	5	5
496	S:S:R330	S:S:V328	6.54	No	No	0	5	4
497	R:R:L323	R:R:T62	2.95	Yes	No	0	5	6
498	R:R:L215	R:R:T219	2.95	No	No	0	5	4
499	R:R:L227	R:R:T223	2.95	No	No	0	4	2
500	R:R:L278	R:R:T261	2.95	No	No	0	4	4
501	S:S:L215	S:S:T219	2.95	No	No	0	5	4
502	S:S:L227	S:S:T223	2.95	No	No	0	4	2
503	S:S:L278	S:S:T261	2.95	Yes	No	0	4	4
504	S:S:L268	S:S:T274	2.95	No	No	0	2	1
505	S:S:L278	S:S:T274	2.95	Yes	No	0	4	1
506	S:S:D37	S:S:S283	2.94	No	No	0	4	4
507	S:S:I295	S:S:I298	2.94	No	No	0	7	7
508	R:R:Q305	R:R:V301	2.87	No	No	0	6	6
509	S:S:K239	S:S:K242	2.87	No	No	0	7	6
510	S:S:E269	S:S:S272	2.87	No	Yes	0	3	4
511	S:S:Q305	S:S:V301	2.87	No	No	0	6	6
512	S:S:E317	S:S:S314	2.87	No	No	0	3	4
513	R:R:I111	R:R:L115	2.85	No	No	0	4	5
514	R:R:I169	R:R:L173	2.85	No	No	0	3	4
515	S:S:I38	S:S:L33	2.85	No	No	0	5	4
516	S:S:I220	S:S:L216	2.85	No	No	0	3	2
517	S:S:I225	S:S:L241	2.85	No	Yes	0	8	6
518	R:R:Q98	R:R:T94	2.83	No	No	0	4	3
519	R:R:E65	R:R:T69	2.82	No	No	0	5	7
520	R:R:K140	R:R:L136	2.82	No	No	0	6	5
521	R:R:K185	R:R:L187	2.82	No	No	0	3	4
522	S:S:K140	S:S:L136	2.82	No	No	0	6	5
523	R:R:G105	R:R:W102	2.81	No	Yes	0	7	8
524	R:R:A56	R:R:F83	2.77	No	No	0	3	8
525	R:R:L315	R:R:L57	2.77	No	No	0	6	5
526	R:R:L319	R:R:L57	2.77	No	No	0	5	5
527	R:R:A303	R:R:F307	2.77	No	No	0	6	9
528	S:S:L315	S:S:L57	2.77	No	No	0	6	5
529	R:R:E321	R:R:K239	2.7	No	No	0	6	7
530	R:R:E321	R:R:K313	2.7	No	No	0	6	4
531	S:S:F251	S:S:S123	2.64	Yes	No	0	9	9
532	S:S:R200	S:S:S266	2.64	No	No	0	3	5
533	R:R:F75	R:R:V243	2.62	No	No	0	8	7
534	S:S:F83	S:S:V52	2.62	No	No	0	8	5
535	S:S:R320	S:S:V61	2.62	No	No	0	6	6
536	S:S:F75	S:S:V243	2.62	No	No	0	8	7
537	S:S:R148	S:S:V328	2.62	Yes	No	0	7	4
538	R:R:A81	R:R:W161	2.59	No	Yes	0	8	9
539	R:R:A108	R:R:W102	2.59	No	Yes	0	5	8
540	S:S:A81	S:S:W161	2.59	No	Yes	0	8	9
541	S:S:R236	S:S:T238	2.59	No	No	0	5	5
542	S:S:V47	S:S:Y290	2.52	No	Yes	0	6	7
543	S:S:V202	S:S:Y192	2.52	No	Yes	0	5	5
544	S:S:V286	S:S:Y258	2.52	No	No	0	5	7
545	S:S:V286	S:S:Y290	2.52	No	Yes	0	5	7
546	R:R:F224	R:R:I220	2.51	No	No	0	3	3
547	S:S:F44	S:S:I96	2.51	Yes	No	0	7	5
548	S:S:F224	S:S:I220	2.51	No	No	0	3	3
549	S:S:S231	S:S:W230	2.47	No	No	0	4	4
550	R:R:F48	R:R:L49	2.44	Yes	No	0	6	4
551	R:R:L92	R:R:W102	2.28	No	Yes	0	6	8
552	S:S:L216	S:S:W213	2.28	No	Yes	0	2	5
553	R:R:F139	R:R:F224	2.14	Yes	No	0	7	3
554	R:R:G105	R:R:G106	2.11	No	No	0	7	3
555	S:S:G105	S:S:G106	2.11	No	No	0	7	3
556	R:R:C86	R:R:G51	1.96	No	No	0	5	8
557	R:R:C294	R:R:G51	1.96	No	No	0	7	8
558	S:S:C109	S:S:G106	1.96	Yes	No	0	9	3
559	R:R:A150	R:R:G151	1.95	No	No	0	3	4
560	R:R:P183	R:R:P184	1.95	No	No	0	4	5
561	R:R:A303	R:R:G304	1.95	No	No	0	6	8
562	S:S:A150	S:S:G151	1.95	No	No	0	3	4
563	S:S:P183	S:S:P184	1.95	No	No	0	4	5
564	R:R:I155	X:X:?1	1.89	No	Yes	0	2	0
565	S:S:G304	S:S:V322	1.84	No	No	0	8	5
566	R:R:G262	R:R:T261	1.82	No	No	0	5	4
567	R:R:A122	R:R:A164	1.79	No	No	0	6	7
568	S:S:A122	S:S:A164	1.79	No	No	0	6	7
569	S:S:P273	S:S:S272	1.78	No	Yes	0	2	4
570	R:R:G149	R:R:I70	1.76	No	Yes	0	5	6
571	S:S:G149	S:S:I70	1.76	No	Yes	0	5	6
572	R:R:G210	R:R:M120	1.75	No	No	0	6	7
573	R:R:G54	R:R:L53	1.71	No	No	0	7	4
574	S:S:G54	S:S:L53	1.71	No	No	0	7	4
575	S:S:A172	S:S:S114	1.71	No	Yes	0	4	5
576	S:S:A303	S:S:V243	1.7	No	No	0	6	7
577	S:S:A303	S:S:V322	1.7	No	No	0	6	5
578	R:R:A72	R:R:T69	1.68	No	No	0	7	7
579	R:R:A72	R:R:T324	1.68	No	No	0	7	5
580	S:S:A232	S:S:T235	1.68	No	No	0	5	4
581	R:R:K140	R:R:P141	1.67	No	No	0	6	8
582	S:S:K140	S:S:P141	1.67	No	No	0	6	8
583	S:S:K185	S:S:P183	1.67	No	No	0	3	4
584	R:R:G306	R:R:Q305	1.64	No	No	0	7	6
585	R:R:A66	R:R:I73	1.62	No	No	0	5	6
586	R:R:A150	R:R:I73	1.62	No	No	0	3	6
587	R:R:A203	R:R:I263	1.62	No	No	0	5	5
588	S:S:A66	S:S:I73	1.62	No	Yes	0	5	6
589	S:S:A150	S:S:I70	1.62	No	Yes	0	3	6
590	S:S:A150	S:S:I73	1.62	No	Yes	0	3	6
591	S:S:A203	S:S:I263	1.62	No	No	0	5	5
592	R:R:V42	R:R:V46	1.6	No	No	0	5	4
593	R:R:V46	R:R:V50	1.6	No	No	0	4	6
594	R:R:S114	R:R:T168	1.6	No	No	0	5	6
595	S:S:V46	S:S:V50	1.6	No	No	0	4	6
596	R:R:C144	R:R:L136	1.59	No	No	0	5	5
597	S:S:C144	S:S:L136	1.59	No	No	0	5	5
598	R:R:A63	R:R:L76	1.58	No	No	0	3	6
599	R:R:A164	R:R:L118	1.58	No	No	0	7	5
600	R:R:A201	S:S:L173	1.58	No	Yes	0	4	4
601	R:R:T219	R:R:T223	1.57	No	No	0	4	2
602	S:S:T219	S:S:T223	1.57	No	No	0	4	2
603	R:R:I204	R:R:V208	1.54	No	No	0	3	4
604	R:R:I298	R:R:V302	1.54	No	No	0	7	6
605	S:S:I155	S:S:V159	1.54	No	No	0	2	1
606	S:S:I204	S:S:V208	1.54	No	No	0	3	4
607	S:S:I298	S:S:V302	1.54	No	No	0	7	6
608	R:R:L137	R:R:V328	1.49	Yes	No	0	8	4
609	R:R:L226	R:R:T229	1.47	No	No	0	5	8
610	R:R:P36	R:R:R34	1.44	Yes	No	0	3	2
611	S:S:E269	S:S:S271	1.44	No	No	0	3	4
612	R:R:I38	R:R:L33	1.43	No	No	0	5	4
613	S:S:I111	S:S:L115	1.43	No	No	0	4	5
614	R:R:E326	R:R:T69	1.41	No	No	0	5	7
615	R:R:G162	R:R:W161	1.41	No	Yes	0	4	9
616	S:S:K185	S:S:L187	1.41	No	No	0	3	4
617	S:S:A56	S:S:F83	1.39	No	No	0	3	8
618	S:S:H194	S:S:S193	1.39	No	No	0	1	4
619	R:R:A142	S:S:R146	1.38	No	No	0	5	5
620	S:S:L33	S:S:L41	1.38	No	Yes	0	4	5
621	S:S:L226	S:S:L241	1.38	No	Yes	0	5	6
622	R:R:V190	R:R:Y174	1.26	No	Yes	0	5	4
623	R:R:D195	R:R:H194	1.26	No	No	0	3	1
624	R:R:F275	R:R:K279	1.24	Yes	No	0	3	4
625	S:S:K196	S:S:R200	1.24	No	No	0	2	3
626	S:S:F275	S:S:K279	1.24	Yes	No	0	3	4
627	S:S:V61	S:S:W60	1.23	No	No	0	6	4
628	S:S:V208	S:S:W213	1.23	No	Yes	0	4	5
629	S:S:F48	S:S:L49	1.22	Yes	No	0	6	4
630	R:R:E234	R:R:R233	1.16	No	No	0	2	4
631	S:S:E234	S:S:R233	1.16	No	No	0	2	4
632	R:R:L57	R:R:W60	1.14	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P36	2.95	5	0	3
2	R:R:F44	5.746	5	2	7
3	R:R:F48	4.9425	4	0	6
4	R:R:I70	6.7525	4	3	6
5	R:R:N71	5.0625	4	3	7
6	R:R:W74	8.21	5	3	7
7	R:R:N77	7.2975	4	13	9
8	R:R:D82	6.2675	4	2	9
9	R:R:L89	7.025	4	2	7
10	R:R:I96	4.1675	4	2	5
11	R:R:H101	5.765	4	15	4
12	R:R:W102	5.68571	7	14	8
13	R:R:N119	4.972	5	2	9
14	R:R:L126	4.335	4	13	7
15	R:R:R134	5.24333	6	3	9
16	R:R:L137	5.44	6	3	8
17	R:R:F139	10.1175	4	0	7
18	R:R:F147	12.6175	4	8	4
19	R:R:R148	10.096	5	3	7
20	R:R:W161	3.444	5	0	9
21	R:R:Y174	7.535	4	0	4
22	R:R:F211	5.5075	4	0	8
23	R:R:Y222	4.828	5	0	8
24	R:R:V247	4.5375	4	10	7
25	R:R:S250	3.4875	4	10	6
26	R:R:F254	10.544	5	0	8
27	R:R:W255	9.944	5	0	9
28	R:R:F275	3.9125	4	0	3
29	R:R:S287	6.3975	4	0	4
30	R:R:Y290	8.10333	6	2	7
31	R:R:I299	4.195	4	10	7
32	R:R:Y300	8.595	4	9	9
33	R:R:L323	8.656	5	9	5
34	R:R:S327	6.2875	4	3	4
35	S:S:P36	3.3275	4	0	3
36	S:S:L41	6.58	4	16	5
37	S:S:F44	5.4475	4	5	7
38	S:S:F48	6.875	4	0	6
39	S:S:V58	3.705	4	12	8
40	S:S:I70	6.6575	4	0	6
41	S:S:N71	4.78	5	4	7
42	S:S:I73	6.0275	4	0	6
43	S:S:W74	7.59667	6	0	7
44	S:S:N77	7.2975	4	17	9
45	S:S:D82	6.605	4	5	9
46	S:S:L89	8.255	4	5	7
47	S:S:H101	6.1275	4	18	4
48	S:S:W102	8.00667	6	6	8
49	S:S:F104	9.2	4	0	7
50	S:S:C109	4.152	5	6	9
51	S:S:S114	3.69	4	6	5
52	S:S:R134	5.596	5	4	9
53	S:S:L137	6.642	5	4	8
54	S:S:F147	8.2275	4	8	4
55	S:S:R148	8.37286	7	4	7
56	S:S:W161	3.9525	4	0	9
57	S:S:L163	4.4825	4	1	4
58	S:S:L173	2.765	4	0	4
59	S:S:R175	6.138	5	6	5
60	S:S:Y192	8.44	4	0	5
61	S:S:R198	12.484	5	11	3
62	S:S:W213	8.068	5	1	5
63	S:S:Y222	4.81	4	0	8
64	S:S:L241	3.305	4	0	6
65	S:S:F251	8.4	5	7	9
66	S:S:F254	10.735	4	7	8
67	S:S:W255	8.08333	6	7	9
68	S:S:Q259	6.5675	4	0	8
69	S:S:S272	2.9025	4	21	4
70	S:S:F275	3.4575	4	21	3
71	S:S:L278	3.595	4	0	4
72	S:S:Y290	6.28625	8	5	7
73	S:S:Y300	8.8525	4	12	9
74	S:S:L323	9.71	4	12	5
75	S:S:S327	6.2875	4	4	4
76	W:W:?1	7.04308	13	1	0
77	X:X:?1	8.23333	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F44	R:R:Y290	14.3593	7.22	Yes	Yes	2	7	7
2	R:R:C293	R:R:Y290	38.3155	4.03	No	Yes	2	8	7
3	R:R:C293	R:R:D82	38.748	6.22	No	Yes	2	8	9
4	R:R:D82	R:R:N296	43.9089	6.73	Yes	No	0	9	9
5	R:R:N296	R:R:V247	52.8647	8.87	No	Yes	0	9	7
6	R:R:L127	R:R:V247	20.0715	2.98	No	Yes	0	8	7
7	R:R:R134	R:R:T238	11.7022	3.88	Yes	No	0	9	5
8	R:R:E325	R:R:T238	11.1747	9.88	No	No	0	8	5
9	R:R:E325	R:R:K239	37.9605	4.05	No	No	0	8	7
10	R:R:E321	R:R:K239	28.5137	2.7	No	No	0	6	7
11	R:R:E321	R:R:K313	26.6208	2.7	No	No	0	6	4
12	R:R:E317	R:R:K313	24.7268	5.4	No	No	0	3	4
13	R:R:E317	R:R:S314	22.8317	5.75	No	No	0	3	4
14	R:R:P316	R:R:S314	20.9354	5.34	No	No	0	5	4
15	R:R:L315	R:R:P316	19.0379	3.28	No	No	0	6	5
16	R:R:L315	R:R:L57	11.4364	2.77	No	No	0	6	5
17	R:R:R134	R:R:T240	11.6941	7.76	Yes	No	3	9	7
18	R:R:E325	R:R:T240	28.6723	9.88	No	No	0	8	7
19	R:R:I70	R:R:W74	11.5175	8.22	Yes	Yes	3	6	7
20	R:R:I70	R:R:R148	10.6113	13.78	Yes	Yes	3	6	7
21	R:R:D133	R:R:W74	37.2622	11.17	No	Yes	3	8	7
22	R:R:D133	R:R:R148	10.4943	16.68	No	Yes	3	8	7
23	R:R:N71	R:R:R148	19.2898	4.82	Yes	Yes	3	7	7
24	R:R:L137	R:R:R134	24.1687	6.07	Yes	Yes	3	8	9
25	R:R:L127	R:R:L78	13.8735	4.15	No	No	0	8	9
26	R:R:L126	R:R:L78	13.3171	4.15	Yes	No	0	7	9
27	R:R:L126	R:R:N77	11.6032	6.87	Yes	Yes	13	7	9
28	R:R:S250	R:R:V247	56.827	3.23	Yes	Yes	10	6	7
29	R:R:N292	R:R:S250	56.4663	2.98	No	Yes	0	9	6
30	R:R:N292	R:R:W255	57.3551	7.91	No	Yes	0	9	9
31	R:R:F251	R:R:W255	60.3076	10.02	No	Yes	0	9	9
32	R:R:F251	R:R:I124	79.5006	15.07	No	No	0	9	8
33	R:R:I124	R:R:P214	79.8903	5.08	No	No	0	8	9
34	R:R:P214	W:W:?1	80.0617	5.43	No	Yes	1	9	0
35	R:R:T129	W:W:?1	56.2266	5.85	No	Yes	0	6	0
36	R:R:L92	R:R:W102	14.6054	2.28	No	Yes	0	6	8
37	R:R:L92	R:R:Y290	15.1746	3.52	No	Yes	0	6	7
38	R:R:V159	W:W:?1	66.2009	9.86	No	Yes	0	1	0
39	R:R:V159	X:X:?1	66.1865	10.84	No	Yes	0	1	0
40	S:S:L163	W:W:?1	69.1256	3.66	Yes	Yes	1	4	0
41	S:S:L163	X:X:?1	66.5785	4.58	Yes	Yes	1	4	0
42	R:R:L209	W:W:?1	17.5243	3.66	No	Yes	1	4	0
43	R:R:L209	R:R:V205	16.9887	2.98	No	No	0	4	3
44	R:R:V205	S:S:L173	15.2783	2.98	No	Yes	0	3	4
45	S:S:L173	S:S:Y174	12.9824	3.52	Yes	No	0	4	4
46	R:R:F251	R:R:F252	22.8074	8.57	No	No	0	9	5
47	R:R:F211	R:R:F252	20.0251	6.43	Yes	No	0	8	5
48	R:R:L256	R:R:V260	12.1637	2.98	No	No	0	5	6
49	R:R:M264	R:R:V260	11.4121	4.56	No	No	0	4	6
50	R:R:L278	R:R:M264	10.6593	5.65	No	No	0	4	4
51	S:S:P214	X:X:?1	99.5339	7.61	No	Yes	1	9	0
52	S:S:I124	S:S:P214	100	6.77	No	No	0	8	9
53	S:S:F251	S:S:I124	99.6155	15.07	Yes	No	0	9	8
54	S:S:F251	S:S:W255	75.6779	11.02	Yes	Yes	7	9	9
55	S:S:I116	S:S:W255	41.6281	4.7	No	Yes	0	6	9
56	S:S:I116	S:S:Y290	41.1336	13.3	No	Yes	0	6	7
57	S:S:F44	S:S:Y290	14.5157	5.16	Yes	Yes	5	7	7
58	S:S:F44	S:S:I96	12.1341	2.51	Yes	No	0	7	5
59	S:S:C293	S:S:Y290	24.3829	4.03	No	Yes	5	8	7
60	S:S:C293	S:S:D82	23.2984	6.22	No	Yes	5	8	9
61	S:S:T129	X:X:?1	47.7762	6.83	No	Yes	1	6	0
62	S:S:T129	S:S:W74	47.4971	3.64	No	Yes	0	6	7
63	S:S:I130	S:S:W74	29.0383	15.27	No	Yes	0	8	7
64	S:S:I130	S:S:V244	28.5131	4.61	No	No	0	8	7
65	S:S:V244	S:S:Y222	28.0117	3.79	No	Yes	0	7	8
66	S:S:V248	S:S:Y222	20.2573	3.79	No	Yes	0	7	8
67	S:S:L127	S:S:V248	19.8856	2.98	No	No	0	8	7
68	S:S:L127	S:S:V247	19.1687	2.98	No	No	0	8	7
69	S:S:N296	S:S:V247	18.8132	8.87	No	No	0	9	7
70	S:S:N296	S:S:Y300	33.6757	9.3	No	Yes	0	9	9
71	S:S:L323	S:S:Y300	24.2242	14.07	Yes	Yes	12	5	9
72	S:S:L323	S:S:V322	23.2596	4.47	Yes	No	0	5	5
73	S:S:G304	S:S:V322	21.1803	1.84	No	No	0	8	5
74	S:S:G304	S:S:L318	20.1322	5.13	No	No	0	8	3
75	S:S:L318	S:S:Q305	19.083	3.99	No	No	0	3	6
76	S:S:Q305	S:S:V301	18.0327	2.87	No	No	0	6	6
77	S:S:L315	S:S:V301	16.9812	2.98	No	No	0	6	6
78	S:S:L315	S:S:L57	10.6478	2.77	No	No	0	6	5
79	S:S:D82	S:S:N296	20.5833	5.39	Yes	No	0	9	9
80	S:S:W255	S:S:Y258	30.4558	5.79	Yes	No	0	9	7
81	S:S:R206	S:S:Y258	34.2304	5.14	No	No	0	6	7
82	S:S:L117	S:S:R206	33.3341	7.29	No	No	0	4	6
83	S:S:L117	S:S:S171	32.7817	4.5	No	No	0	4	5
84	S:S:R175	S:S:S171	29.2983	3.95	Yes	No	6	5	5
85	S:S:C109	S:S:R175	15.3425	4.18	Yes	Yes	6	9	5
86	S:S:C109	S:S:W102	12.441	3.92	Yes	Yes	6	9	8
87	S:S:P113	S:S:R175	12.9824	12.97	No	Yes	0	6	5
88	S:S:P113	S:S:W102	12.4051	4.05	No	Yes	0	6	8
89	S:S:F104	S:S:W102	16.6257	16.04	Yes	Yes	0	7	8
90	S:S:F104	S:S:P103	11.8875	10.11	Yes	No	0	7	3
91	S:S:F251	S:S:F252	20.5798	9.65	Yes	No	0	9	5
92	S:S:F211	S:S:F252	18.0408	7.5	No	No	0	8	5
93	S:S:F211	S:S:L256	15.987	4.87	No	No	0	8	5
94	S:S:L256	S:S:V260	14.8341	2.98	No	No	0	5	6
95	S:S:M264	S:S:V260	14.1393	4.56	No	No	0	4	6
96	S:S:L278	S:S:M264	13.4433	4.24	Yes	No	0	4	4
97	S:S:C144	S:S:L136	10.2482	1.59	No	No	0	5	5
98	R:R:N71	R:R:T240	18.3303	5.85	Yes	No	3	7	7
99	R:R:D133	R:R:L137	26.3116	5.43	No	Yes	3	8	8
100	R:R:T129	R:R:W74	55.8259	4.85	No	Yes	0	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V159	W:W:?1	9.86	0	No	Yes	1	0	1	2
R:R:V159	X:X:?1	10.84	0	No	Yes	1	0	1	0
S:S:T129	S:S:W74	3.64	1	No	Yes	6	7	1	2
S:S:I124	S:S:P214	6.77	0	No	No	8	9	2	1
S:S:A160	S:S:L125	3.15	0	No	No	6	6	2	1
S:S:L125	S:S:L163	5.54	1	No	Yes	6	4	1	1
S:S:L125	X:X:?1	7.33	1	No	Yes	6	0	1	0
S:S:A128	X:X:?1	9.38	0	No	Yes	7	0	1	0
S:S:L156	S:S:T129	4.42	1	No	No	5	6	1	1
S:S:T129	X:X:?1	6.83	1	No	Yes	6	0	1	0
S:S:L152	S:S:L156	5.54	0	No	No	3	5	2	1
S:S:L156	X:X:?1	5.5	1	No	Yes	5	0	1	0
S:S:V159	X:X:?1	9.86	0	No	Yes	1	0	1	0
S:S:L163	S:S:L167	4.15	1	Yes	No	4	4	1	2
S:S:L163	W:W:?1	3.66	1	Yes	Yes	4	0	1	2
S:S:L163	X:X:?1	4.58	1	Yes	Yes	4	0	1	0
S:S:L209	S:S:V205	2.98	0	No	No	4	3	1	2
S:S:L209	X:X:?1	8.24	0	No	Yes	4	0	1	0
S:S:P214	S:S:W213	4.05	1	No	Yes	9	5	1	1
S:S:T217	S:S:W213	10.92	1	No	Yes	5	5	1	1
S:S:W213	X:X:?1	21.86	1	Yes	Yes	5	0	1	0
S:S:P214	X:X:?1	7.61	1	No	Yes	9	0	1	0
S:S:T217	X:X:?1	4.88	1	No	Yes	5	0	1	0
S:S:L216	S:S:W213	2.28	0	No	Yes	2	5	2	1
R:R:I155	X:X:?1	1.89	0	No	Yes	2	0	1	0
S:S:I155	S:S:V159	1.54	0	No	No	2	1	2	1
S:S:V208	S:S:W213	1.23	0	No	Yes	4	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:T129	R:R:W74	4.85	0	No	Yes	6	7	1	2
R:R:I124	R:R:P214	5.08	0	No	No	8	9	2	1
R:R:L125	R:R:L163	5.54	1	No	No	6	4	1	1
R:R:L125	W:W:?1	8.24	1	No	Yes	6	0	1	0
R:R:A128	W:W:?1	9.38	0	No	Yes	7	0	1	0
R:R:T129	W:W:?1	5.85	0	No	Yes	6	0	1	0
R:R:L152	R:R:L156	4.15	0	No	No	3	5	2	1
R:R:L156	W:W:?1	3.66	0	No	Yes	5	0	1	0
R:R:V159	W:W:?1	9.86	0	No	Yes	1	0	1	0
R:R:V159	X:X:?1	10.84	0	No	Yes	1	0	1	2
R:R:L163	S:S:L166	4.15	1	No	No	4	4	1	1
R:R:L163	W:W:?1	3.66	1	No	Yes	4	0	1	0
R:R:L209	R:R:V205	2.98	1	No	No	4	3	1	2
R:R:L209	S:S:L166	4.15	1	No	No	4	4	1	1
R:R:L209	W:W:?1	3.66	1	No	Yes	4	0	1	0
R:R:P214	R:R:W213	4.05	1	No	No	9	5	1	1
R:R:T217	R:R:W213	10.92	1	No	No	5	5	1	1
R:R:W213	W:W:?1	19.59	1	No	Yes	5	0	1	0
R:R:P214	W:W:?1	5.43	1	No	Yes	9	0	1	0
R:R:T217	W:W:?1	4.88	1	No	Yes	5	0	1	0
S:S:L125	S:S:L163	5.54	1	No	Yes	6	4	2	1
S:S:L125	X:X:?1	7.33	1	No	Yes	6	0	2	2
S:S:G162	W:W:?1	4.53	0	No	Yes	4	0	1	0
S:S:L163	S:S:L167	4.15	1	Yes	No	4	4	1	2
S:S:L163	W:W:?1	3.66	1	Yes	Yes	4	0	1	0
S:S:L163	X:X:?1	4.58	1	Yes	Yes	4	0	1	2
S:S:L166	W:W:?1	9.16	1	No	Yes	4	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	5O9H_poly
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	558
Number of Links	632
Number of Hubs	77
Number of Links mediated by Hubs	311
Number of Communities	21
Number of Nodes involved in Communities	112
Number of Links involved in Communities	145

Path Summary
Number Of Nodes in MetaPath	101
Number Of Links MetaPath	100
Number of Shortest Paths	359508
Length Of Smallest Path	3
Average Path Length	20.8723
Length of Longest Path	47
Minimum Path Strength	1.385
Average Path Strength	6.57599
Maximum Path Strength	20.03
Minimum Path Correlation	0.7
Average Path Correlation	0.96299
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	47.257
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.3306
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • cellular process • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • multicellular organismal process • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • regulation of cytokine production • cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of vascular endothelial growth factor production • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • vascular endothelial growth factor production • biosynthetic process • positive regulation of gene expression • positive regulation of multicellular organismal process • positive regulation of vascular endothelial growth factor production • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • positive regulation of cytokine production • regulation of metabolic process • cellular component organization • cell junction organization • presynapse organization • synapse organization • cellular component organization or biogenesis • immune response • immune system process • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • cell surface receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • regulation of immune response • activation of immune response • amyloid-beta clearance • cell chemotaxis • chemotaxis • neutrophil chemotaxis • response to external stimulus • neutrophil migration • granulocyte migration • leukocyte migration • cellular response to chemical stimulus • taxis • granulocyte chemotaxis • response to chemical • myeloid leukocyte migration • cell migration • cell motility • leukocyte chemotaxis • locomotion • system process • nervous system process • cognition • cell population proliferation • positive regulation of cell population proliferation • positive regulation of epithelial cell proliferation • regulation of cell population proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • positive regulation of locomotion • regulation of cell motility • positive regulation of chemotaxis • positive regulation of cell migration • positive regulation of neutrophil chemotaxis • regulation of leukocyte chemotaxis • regulation of leukocyte migration • positive regulation of leukocyte chemotaxis • positive regulation of granulocyte chemotaxis • regulation of locomotion • regulation of neutrophil chemotaxis • regulation of neutrophil migration • regulation of response to external stimulus • regulation of granulocyte chemotaxis • positive regulation of response to external stimulus • positive regulation of cell motility • regulation of cell migration • positive regulation of leukocyte migration • positive regulation of neutrophil migration • regulation of chemotaxis • macrophage migration • regulation of mononuclear cell migration • positive regulation of macrophage migration • macrophage chemotaxis • regulation of macrophage migration • positive regulation of mononuclear cell migration • regulation of macrophage chemotaxis • mononuclear cell migration • positive regulation of macrophage chemotaxis • cellular developmental process • astrocyte differentiation • cell development • astrocyte activation • glial cell development • multicellular organism development • neurogenesis • astrocyte development • gliogenesis • cell differentiation • response to stress • anatomical structure development • system development • developmental process • defense response • cell activation • nervous system development • central nervous system development • glial cell differentiation • glial cell activation • inflammatory response • neuroinflammatory response • regulation of developmental process • angiogenesis • regulation of vasculature development • positive regulation of developmental process • tube morphogenesis • regulation of anatomical structure morphogenesis • blood vessel development • regulation of multicellular organismal development • blood vessel morphogenesis • tube development • positive regulation of angiogenesis • vasculature development • circulatory system development • anatomical structure morphogenesis • positive regulation of vasculature development • regulation of angiogenesis • anatomical structure formation involved in morphogenesis • complement component C5a signaling pathway • G protein-coupled receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • mRNA transcription by RNA polymerase II • RNA metabolic process • primary metabolic process • nucleobase-containing compound biosynthetic process • mRNA transcription • mRNA metabolic process • nucleic acid metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • DNA-templated transcription • nucleic acid biosynthetic process • transcription by RNA polymerase II • cellular defense response • sensory perception of chemical stimulus • sensory perception • biological process involved in interspecies interaction between organisms • response to other organism • response to oxygen-containing compound • response to nitrogen compound • response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • response to peptidoglycan • myeloid leukocyte activation • leukocyte activation • macrophage activation • leukocyte activation involved in inflammatory response • microglial cell activation • defense response to Gram-positive bacterium • defense response to bacterium • cellular anatomical structure • apical part of cell • cell periphery • plasma membrane • membrane • basal part of cell • basal plasma membrane • plasma membrane region • basolateral plasma membrane • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system
Gene Ontology	Cellular Component	• cellular anatomical structure • apical part of cell • cell periphery • plasma membrane • membrane • basal part of cell • basal plasma membrane • plasma membrane region • basolateral plasma membrane • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle membrane • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • organelle membrane • secretory granule membrane
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	9P2
PDB Residues	W:W:?1 X:X:?1
Environment Details	Open EMBL-EBI Page
Code	9P2
Name	1-(1,3-benzodioxol-5-yl)-~{N}-(1,3-benzodioxol-5-ylmethyl)-~{N}-[(3-butyl-2,5-diphenyl-imidazol-4-yl)methyl]methanamine
Synonyms
Identifier
Formula	C36 H35 N3 O4
Molecular Weight	573.681
SMILES
PubChem	10210160
Formal Charge	0
Total Atoms	78
Total Chiral Atoms	0
Total Bonds	84
Total Aromatic Bonds	29


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21730
Sequence	>5O9H_poly_Chain_R N T L R V P D I L A L V I F A V V F L V G V L G N A L V V W V T A F E A K R T I N A I W F L N L A V A D F L A C L A L P A L F T S I V Q H H H W P F G G A A C S I L P S L I L L N M Y A S I L L L A T I S A D R F L L V F K P A W C Q R F R G A G L A W I L C A V A W G L A L L L T I P S A L Y R V V R E E Y F P P K V L C G V D H D K R R E R A V A I V R L V L G F L W P L L T L T I C Y T F I L L R T W S A R E T R S T K T L K V V V A V V A S F F I F W L P Y Q V T G I M M S F L E P S S P T F L L L K K L D S L C V S F A Y I N C C I N P I I Y V V A G Q G F Q K S L P E L L R E V L T E E S V V R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5O9H	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	-	NDT9513727	-	2.7	2018-01-10	doi.org/10.1038/nature25025
	6C1Q	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	PMX53	NDT9513727	-	2.9	2018-05-30	doi.org/10.1038/s41594-018-0067-z
	6C1R	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	PMX53	Avacopan; Na	-	2.2	2018-05-30	doi.org/10.1038/s41594-018-0067-z
	8HPT	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin C-terminal peptide	-	Go/β1/γ2	3.39	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HPT (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin C-terminal peptide	-		3.39	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HQC	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin	-	Go/β1/γ2	3.89	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8HQC (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Mus musculus	C5a anaphylatoxin	-		3.89	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8IA2	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-	Go/β1/γ2	3.21	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8IA2 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-		3.21	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8JZZ	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-desArg	-	Go/β1/γ2	3.31	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	8JZZ (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a-desArg	-		3.31	2023-10-18	doi.org/10.1016/j.cell.2023.09.020
	7Y64	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y64 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y65	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a peptide	-	Gi1/β1/γ2	3.2	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y65 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5a peptide	-		3.2	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-	Gi1/β1/γ2	2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y66 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	BM213	-		2.9	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y67	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C089 peptide	-	Gi1/β1/γ2	2.8	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	7Y67 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C089 peptide	-		2.8	2023-03-01	doi.org/10.1038/s41422-023-00779-2
	8HK5	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	Complement C5	-	Gi1/β1/γ2	3	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8HK5 (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	Complement C5	-		3	2023-05-10	doi.org/10.1038/s41589-023-01339-w
	8JZP	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5A anaphylatoxin	-	Go/β1/γ2	3.54	2025-01-15	To be published
	8JZP (No Gprot)	A	Peptide	Complement Peptide	C5a₁	Homo sapiens	C5A anaphylatoxin	-		3.54	2025-01-15	To be published

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Download 5O9H_poly.zip

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