psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N31	R:R:T32	4.39	No	No	0	1	4
2	R:R:D37	R:R:L33	4.07	No	No	0	4	4
3	R:R:H99	R:R:L33	7.71	No	No	0	2	4
4	R:R:K280	R:R:R34	11.14	No	No	0	2	2
5	R:R:P36	R:R:V35	3.53	Yes	No	0	3	3
6	R:R:L39	R:R:V35	2.98	No	No	0	5	3
7	R:R:D37	R:R:P36	3.22	No	Yes	0	4	3
8	R:R:L281	R:R:P36	3.28	No	Yes	0	5	3
9	R:R:L284	R:R:P36	3.28	No	Yes	0	4	3
10	R:R:D37	R:R:H100	5.04	No	No	0	4	4
11	R:R:A40	R:R:S287	3.42	No	Yes	0	6	4
12	R:R:F93	R:R:L41	12.18	No	No	2	7	5
13	R:R:I96	R:R:L41	4.28	Yes	No	2	5	5
14	R:R:L41	R:R:V97	2.98	No	No	2	5	3
15	R:R:I43	R:R:S287	12.39	No	Yes	0	5	4
16	R:R:F44	R:R:L89	8.53	Yes	Yes	2	7	7
17	R:R:F44	R:R:I96	3.77	Yes	Yes	2	7	5
18	R:R:F44	R:R:V286	3.93	Yes	No	0	7	5
19	R:R:F44	R:R:S287	5.28	Yes	Yes	0	7	4
20	R:R:F44	R:R:Y290	7.22	Yes	Yes	2	7	7
21	R:R:L89	R:R:V47	2.98	Yes	No	0	7	6
22	R:R:C294	R:R:V47	6.83	No	No	0	7	6
23	R:R:F48	R:R:V52	5.24	Yes	No	0	6	5
24	R:R:F48	R:R:L89	4.87	Yes	Yes	0	6	7
25	R:R:F48	R:R:P90	7.22	Yes	No	0	6	9
26	R:R:C294	R:R:V50	3.42	No	No	0	7	6
27	R:R:I298	R:R:V50	3.07	No	No	0	7	6
28	R:R:F83	R:R:V52	5.24	No	No	0	8	5
29	R:R:G54	R:R:P297	4.06	No	No	0	7	9
30	R:R:A79	R:R:N55	3.13	No	No	0	8	9
31	R:R:D82	R:R:N55	5.39	Yes	No	0	9	9
32	R:R:N55	R:R:P297	6.52	No	No	0	9	9
33	R:R:A79	R:R:V58	3.39	No	No	0	8	8
34	R:R:V58	R:R:Y300	3.79	No	Yes	9	8	9
35	R:R:L323	R:R:V58	4.47	Yes	No	9	5	8
36	R:R:L76	R:R:V59	4.47	No	No	0	6	7
37	R:R:F64	R:R:W60	14.03	No	No	0	4	4
38	R:R:L319	R:R:V61	4.47	No	No	0	5	6
39	R:R:R320	R:R:V61	6.54	No	No	0	6	6
40	R:R:A72	R:R:T62	3.36	No	No	0	7	6
41	R:R:L76	R:R:T62	5.9	No	No	0	6	6
42	R:R:E65	R:R:T324	14.11	No	No	0	5	5
43	R:R:I70	R:R:W74	8.22	Yes	Yes	3	6	7
44	R:R:I70	R:R:R148	13.78	Yes	Yes	3	6	7
45	R:R:A153	R:R:I70	3.25	No	Yes	3	7	6
46	R:R:N71	R:R:R134	3.62	Yes	Yes	3	7	9
47	R:R:N71	R:R:R148	4.82	Yes	Yes	3	7	7
48	R:R:N71	R:R:T240	5.85	Yes	No	3	7	7
49	R:R:N71	R:R:S327	5.96	Yes	Yes	3	7	4
50	R:R:I73	R:R:W154	21.14	No	No	0	6	3
51	R:R:T129	R:R:W74	4.85	No	Yes	0	6	7
52	R:R:I130	R:R:W74	12.92	No	Yes	0	8	7
53	R:R:D133	R:R:W74	11.17	No	Yes	3	8	7
54	R:R:A153	R:R:W74	3.89	No	Yes	3	7	7
55	R:R:F75	R:R:Y300	7.22	No	Yes	9	8	9
56	R:R:F75	R:R:L323	15.83	No	Yes	9	8	5
57	R:R:L126	R:R:N77	6.87	Yes	Yes	13	7	9
58	R:R:N77	R:R:W154	5.65	Yes	No	0	9	3
59	R:R:C157	R:R:N77	11.02	No	Yes	13	6	9
60	R:R:N77	R:R:W161	5.65	Yes	Yes	0	9	9
61	R:R:L126	R:R:L78	4.15	Yes	No	0	7	9
62	R:R:L127	R:R:L78	4.15	No	No	0	8	9
63	R:R:L84	R:R:V80	2.98	No	No	0	6	5
64	R:R:V80	R:R:W161	3.68	No	Yes	0	5	9
65	R:R:D82	R:R:N119	6.73	Yes	Yes	2	9	9
66	R:R:C293	R:R:D82	6.22	No	Yes	2	8	9
67	R:R:D82	R:R:N296	6.73	Yes	No	0	9	9
68	R:R:F83	R:R:L87	4.87	No	No	0	8	4
69	R:R:A85	R:R:N119	4.69	No	Yes	0	6	9
70	R:R:A85	R:R:Y290	4	No	Yes	0	6	7
71	R:R:A88	R:R:L112	4.73	No	No	0	6	5
72	R:R:A88	R:R:L115	4.73	No	No	0	6	5
73	R:R:L89	R:R:Y290	11.72	Yes	Yes	2	7	7
74	R:R:A91	R:R:F104	5.55	No	No	0	6	7
75	R:R:L92	R:R:Y290	3.52	No	Yes	0	6	7
76	R:R:F93	R:R:V97	3.93	No	No	2	7	3
77	R:R:S95	R:R:W102	4.94	No	Yes	0	4	8
78	R:R:H100	R:R:I96	3.98	No	Yes	2	4	5
79	R:R:I96	R:R:S283	4.64	Yes	No	2	5	4
80	R:R:H101	R:R:Q98	6.18	Yes	No	15	4	4
81	R:R:P103	R:R:Q98	3.16	No	No	15	3	4
82	R:R:H100	R:R:S283	5.58	No	No	2	4	4
83	R:R:H101	R:R:P103	6.1	Yes	No	15	4	3
84	R:R:H101	R:R:K185	5.24	Yes	No	0	4	3
85	R:R:H101	R:R:V186	5.54	Yes	No	0	4	6
86	R:R:F104	R:R:W102	18.04	No	Yes	0	7	8
87	R:R:C109	R:R:W102	3.92	No	Yes	14	9	8
88	R:R:C188	R:R:W102	5.22	No	Yes	14	9	8
89	R:R:F104	R:R:P103	13	No	No	0	7	3
90	R:R:A108	R:R:L112	3.15	No	No	0	5	5
91	R:R:C109	R:R:V177	3.42	No	No	0	9	4
92	R:R:C109	R:R:C188	7.28	No	No	14	9	9
93	R:R:P113	R:R:R175	8.65	No	No	0	6	5
94	R:R:L117	R:R:S114	3	No	No	0	4	5
95	R:R:A172	R:R:S114	3.42	No	No	0	4	5
96	R:R:I116	R:R:N119	4.25	No	Yes	0	6	9
97	R:R:I116	R:R:Y290	18.13	No	Yes	0	6	7
98	R:R:L117	R:R:S171	3	No	No	0	4	5
99	R:R:L118	R:R:L165	4.15	No	No	0	5	4
100	R:R:L118	R:R:T168	8.84	No	No	0	5	6
101	R:R:N119	R:R:S123	4.47	Yes	No	0	9	9
102	R:R:C293	R:R:N119	4.72	No	Yes	2	8	9
103	R:R:M120	R:R:Y121	8.38	No	No	0	7	7
104	R:R:M120	R:R:W255	16.29	No	Yes	0	7	9
105	R:R:L167	R:R:Y121	12.89	No	No	0	4	7
106	R:R:A122	R:R:W161	3.89	No	Yes	0	6	9
107	R:R:I124	R:R:P214	5.08	No	No	0	8	9
108	R:R:F251	R:R:I124	15.07	No	No	0	9	8
109	R:R:L125	R:R:L163	5.54	No	No	1	6	4
110	R:R:L125	W:W:?1	8.24	No	Yes	1	6	0
111	R:R:C157	R:R:L126	3.17	No	Yes	13	6	7
112	R:R:A160	R:R:L126	3.15	No	Yes	0	6	7
113	R:R:L127	R:R:V247	2.98	No	Yes	0	8	7
114	R:R:L127	R:R:V248	4.47	No	No	0	8	7
115	R:R:A128	W:W:?1	9.38	No	Yes	0	7	0
116	R:R:T129	W:W:?1	5.85	No	Yes	0	6	0
117	R:R:I130	R:R:V244	3.07	No	No	0	8	7
118	R:R:L218	R:R:S131	3	No	No	0	8	9
119	R:R:S131	R:R:Y222	8.9	No	Yes	0	9	8
120	R:R:D133	R:R:L137	5.43	No	Yes	3	8	8
121	R:R:D133	R:R:R148	16.68	No	Yes	3	8	7
122	R:R:L137	R:R:R134	6.07	Yes	Yes	3	8	9
123	R:R:R134	R:R:T238	3.88	Yes	No	0	9	5
124	R:R:R134	R:R:T240	7.76	Yes	No	3	9	7
125	R:R:L241	R:R:R134	4.86	No	Yes	0	6	9
126	R:R:R134	R:R:S327	5.27	Yes	Yes	3	9	4
127	R:R:F135	R:R:F139	16.08	No	Yes	0	8	7
128	R:R:F135	R:R:I225	5.02	No	No	0	8	8
129	R:R:L136	R:R:W143	3.42	No	No	0	5	5
130	R:R:C144	R:R:L137	6.35	No	Yes	0	5	8
131	R:R:L137	R:R:R148	7.29	Yes	Yes	3	8	7
132	R:R:L137	R:R:S327	6.01	Yes	Yes	3	8	4
133	R:R:F139	R:R:V138	10.49	Yes	No	0	7	8
134	R:R:F139	R:R:R228	11.76	Yes	No	0	7	5
135	R:R:F147	R:R:W143	20.04	Yes	No	8	4	5
136	R:R:W143	S:S:F147	4.01	No	Yes	8	5	4
137	R:R:Q145	R:R:V328	4.3	No	No	0	5	4
138	R:R:F147	R:R:R146	9.62	Yes	No	8	4	5
139	R:R:R146	S:S:W143	13.99	No	No	8	5	5
140	R:R:R146	S:S:F147	3.21	No	Yes	8	5	4
141	R:R:F147	S:S:W143	9.02	Yes	No	8	4	5
142	R:R:F147	S:S:F147	11.79	Yes	Yes	8	4	4
143	R:R:R148	R:R:S327	7.91	Yes	Yes	3	7	4
144	R:R:L152	R:R:L156	4.15	No	No	0	3	5
145	R:R:L156	W:W:?1	3.66	No	Yes	0	5	0
146	R:R:V159	W:W:?1	9.86	No	Yes	0	1	0
147	K:K:?1	R:R:V159	10.84	Yes	No	0	0	1
148	R:R:L163	S:S:L166	4.15	No	No	1	4	4
149	R:R:L163	W:W:?1	3.66	No	Yes	1	4	0
150	R:R:L166	S:S:V205	2.98	No	No	0	4	3
151	R:R:I169	R:R:P170	3.39	No	No	0	3	8
152	R:R:L173	S:S:R197	3.64	No	No	11	4	1
153	R:R:L173	S:S:R198	10.93	No	Yes	11	4	3
154	R:R:D191	R:R:Y174	3.45	No	Yes	0	4	4
155	R:R:Y174	S:S:Y174	7.94	Yes	No	0	4	4
156	R:R:Y174	S:S:R198	17.49	Yes	Yes	0	4	3
157	R:R:C188	R:R:R175	4.18	No	No	0	9	5
158	R:R:G189	R:R:R175	3	No	No	0	4	5
159	R:R:E179	R:R:Y181	12.35	No	No	0	2	1
160	R:R:E180	R:R:L187	5.3	No	No	0	1	4
161	R:R:F182	R:R:Y181	6.19	No	No	0	3	1
162	R:R:E199	R:R:H194	14.77	No	No	0	4	1
163	R:R:D195	R:R:R197	4.76	No	No	0	3	1
164	R:R:D195	R:R:R198	7.15	No	No	0	3	3
165	R:R:R198	S:S:S110	3.95	No	No	0	3	6
166	R:R:R198	S:S:V176	5.23	No	No	0	3	4
167	R:R:F267	R:R:R200	16.03	No	No	0	4	3
168	R:R:R206	R:R:V202	6.54	No	No	0	6	5
169	R:R:V202	S:S:L173	2.98	No	Yes	0	5	4
170	R:R:A203	R:R:S266	3.42	No	No	0	5	5
171	R:R:F267	R:R:I204	5.02	No	No	0	4	3
172	R:R:L209	R:R:V205	2.98	No	No	0	4	3
173	R:R:V205	S:S:I169	3.07	No	No	0	3	3
174	R:R:V205	S:S:L173	2.98	No	Yes	0	3	4
175	R:R:L207	R:R:L212	6.92	No	No	0	5	4
176	R:R:L207	R:R:Q259	6.65	No	No	0	5	8
177	R:R:I263	R:R:L207	5.71	No	No	0	5	5
178	R:R:L209	S:S:L166	4.15	No	No	1	4	4
179	R:R:L209	W:W:?1	3.66	No	Yes	1	4	0
180	R:R:F211	R:R:L212	3.65	Yes	No	0	8	4
181	R:R:F211	R:R:F252	6.43	Yes	No	0	8	5
182	R:R:F211	R:R:L256	6.09	Yes	No	0	8	5
183	R:R:F211	R:R:Q259	5.86	Yes	No	0	8	8
184	R:R:P214	R:R:W213	4.05	No	No	1	9	5
185	R:R:T217	R:R:W213	10.92	No	No	1	5	5
186	R:R:W213	W:W:?1	19.59	No	Yes	1	5	0
187	R:R:P214	W:W:?1	5.43	No	Yes	1	9	0
188	R:R:F252	R:R:L215	14.61	No	No	0	5	5
189	R:R:I220	R:R:L216	4.28	No	No	0	3	2
190	R:R:T217	W:W:?1	4.88	No	Yes	1	5	0
191	R:R:L218	R:R:V248	2.98	No	No	0	8	7
192	R:R:C221	R:R:Y222	4.03	No	Yes	0	6	8
193	R:R:I225	R:R:Y222	3.63	No	Yes	0	8	8
194	R:R:V244	R:R:Y222	3.79	No	Yes	0	7	8
195	R:R:V245	R:R:Y222	3.79	No	Yes	0	4	8
196	R:R:R228	R:R:T235	3.88	No	No	0	5	4
197	R:R:T229	R:R:T235	3.14	No	No	0	8	4
198	R:R:S237	R:R:T229	3.2	No	No	0	7	8
199	R:R:S231	R:R:W230	3.71	No	No	0	4	4
200	R:R:A232	R:R:T235	3.36	No	No	0	5	4
201	R:R:L241	R:R:S237	4.5	No	No	0	6	7
202	R:R:K242	R:R:S237	6.12	No	No	0	6	7
203	R:R:E325	R:R:T238	9.88	No	No	0	8	5
204	R:R:F307	R:R:K239	21.09	No	No	0	9	7
205	R:R:E325	R:R:K239	4.05	No	No	0	8	7
206	R:R:E325	R:R:T240	9.88	No	No	0	8	7
207	R:R:L241	R:R:V245	2.98	No	No	0	6	4
208	R:R:A246	R:R:I299	3.25	No	Yes	0	5	7
209	R:R:S250	R:R:V247	3.23	Yes	Yes	10	6	7
210	R:R:N296	R:R:V247	8.87	No	Yes	0	9	7
211	R:R:I299	R:R:V247	3.07	Yes	Yes	10	7	7
212	R:R:N292	R:R:S250	2.98	No	Yes	0	9	6
213	R:R:I295	R:R:S250	4.64	No	Yes	10	7	6
214	R:R:I299	R:R:S250	3.1	Yes	Yes	10	7	6
215	R:R:F251	R:R:F252	8.57	No	No	0	9	5
216	R:R:F251	R:R:W255	10.02	No	Yes	0	9	9
217	R:R:F254	R:R:I253	3.77	Yes	No	0	8	5
218	R:R:F254	R:R:F288	12.86	Yes	No	0	8	8
219	R:R:F254	R:R:I291	20.09	Yes	No	0	8	5
220	R:R:F254	R:R:N292	8.46	Yes	No	0	8	9
221	R:R:F254	R:R:I295	7.54	Yes	No	0	8	7
222	R:R:W255	R:R:Y258	7.72	Yes	No	0	9	7
223	R:R:A289	R:R:W255	7.78	No	Yes	0	8	9
224	R:R:N292	R:R:W255	7.91	No	Yes	0	9	9
225	R:R:L256	R:R:P257	3.28	No	No	0	5	9
226	R:R:L256	R:R:V260	2.98	No	No	0	5	6
227	R:R:F288	R:R:P257	7.22	No	No	0	8	9
228	R:R:M264	R:R:V260	4.56	No	No	0	4	6
229	R:R:C285	R:R:T261	6.76	No	No	0	6	4
230	R:R:F267	R:R:I263	5.02	No	No	0	4	5
231	R:R:L278	R:R:M264	5.65	No	No	0	4	4
232	R:R:F275	R:R:M265	4.98	Yes	No	0	3	4
233	R:R:L278	R:R:M265	5.65	No	No	0	4	4
234	R:R:L268	R:R:T274	4.42	No	No	0	2	1
235	R:R:F275	R:R:L268	3.65	Yes	No	0	3	2
236	R:R:E269	R:R:P270	3.14	No	No	0	3	3
237	R:R:E269	R:R:S271	4.31	No	No	0	3	4
238	R:R:F275	R:R:P270	5.78	Yes	No	0	3	3
239	R:R:P273	R:R:S272	3.56	No	No	0	2	4
240	R:R:S272	R:R:T274	4.8	No	No	0	4	1
241	R:R:K280	R:R:L276	7.05	No	No	0	2	3
242	R:R:L277	R:R:L281	4.15	No	No	0	1	5
243	R:R:D282	R:R:V286	4.38	No	No	0	4	5
244	R:R:L284	R:R:S287	4.5	No	Yes	0	4	4
245	R:R:C293	R:R:Y290	4.03	No	Yes	2	8	7
246	R:R:I295	R:R:I299	7.36	No	Yes	10	7	7
247	R:R:N296	R:R:Y300	9.3	No	Yes	0	9	9
248	R:R:L323	R:R:Y300	14.07	Yes	Yes	9	5	9
249	R:R:L315	R:R:V301	2.98	No	No	0	6	6
250	R:R:G304	R:R:L318	5.13	No	No	0	8	3
251	R:R:E317	R:R:K313	5.4	No	No	0	3	4
252	R:R:P316	R:R:S314	5.34	No	No	0	5	4
253	R:R:E317	R:R:S314	5.75	No	No	0	3	4
254	R:R:L315	R:R:P316	3.28	No	No	0	6	5
255	R:R:L323	R:R:V322	5.96	Yes	No	0	5	5
256	R:R:R330	R:R:V328	7.85	No	No	0	5	4
257	S:S:H99	S:S:L33	3.86	No	No	0	2	4
258	S:S:D37	S:S:R34	4.76	No	No	0	4	2
259	S:S:K280	S:S:R34	9.9	No	No	0	2	2
260	S:S:P36	S:S:V35	3.53	Yes	No	0	3	3
261	S:S:D37	S:S:P36	3.22	No	Yes	0	4	3
262	S:S:L281	S:S:P36	3.28	No	Yes	0	5	3
263	S:S:L284	S:S:P36	3.28	No	Yes	0	4	3
264	S:S:L284	S:S:L39	4.15	No	No	0	4	5
265	S:S:A40	S:S:S287	3.42	No	No	0	6	4
266	S:S:F93	S:S:L41	13.4	No	Yes	16	7	5
267	S:S:I96	S:S:L41	8.56	No	Yes	0	5	5
268	S:S:L41	S:S:V97	2.98	Yes	No	16	5	3
269	S:S:I43	S:S:S287	10.84	No	No	0	5	4
270	S:S:F44	S:S:L89	4.87	Yes	Yes	5	7	7
271	S:S:F44	S:S:S287	9.25	Yes	No	0	7	4
272	S:S:F44	S:S:Y290	5.16	Yes	Yes	5	7	7
273	S:S:C294	S:S:V47	8.54	No	No	0	7	6
274	S:S:F48	S:S:V52	7.87	Yes	No	0	6	5
275	S:S:F48	S:S:L89	9.74	Yes	Yes	0	6	7
276	S:S:F48	S:S:P90	8.67	Yes	No	0	6	9
277	S:S:C294	S:S:V50	3.42	No	No	0	7	6
278	S:S:G51	S:S:N55	3.39	No	No	0	8	9
279	S:S:G54	S:S:P297	4.06	No	No	0	7	9
280	S:S:D82	S:S:N55	8.08	Yes	No	0	9	9
281	S:S:N55	S:S:P297	4.89	No	No	0	9	9
282	S:S:L319	S:S:L57	4.15	No	No	0	5	5
283	S:S:T62	S:S:V58	3.17	No	Yes	0	6	8
284	S:S:A79	S:S:V58	3.39	No	Yes	0	8	8
285	S:S:V58	S:S:Y300	3.79	Yes	Yes	12	8	9
286	S:S:L323	S:S:V58	4.47	Yes	Yes	12	5	8
287	S:S:L76	S:S:V59	4.47	No	No	0	6	7
288	S:S:F64	S:S:W60	8.02	No	No	0	4	4
289	S:S:L319	S:S:V61	2.98	No	No	0	5	6
290	S:S:L76	S:S:T62	5.9	No	No	0	6	6
291	S:S:E65	S:S:R320	5.82	No	No	0	5	6
292	S:S:E65	S:S:T324	12.7	No	No	0	5	5
293	S:S:A72	S:S:T69	3.36	No	No	0	7	7
294	S:S:T324	S:S:T69	4.71	No	No	0	5	7
295	S:S:I70	S:S:W74	8.22	Yes	Yes	0	6	7
296	S:S:I70	S:S:R148	15.03	Yes	Yes	0	6	7
297	S:S:N71	S:S:W74	3.39	Yes	Yes	0	7	7
298	S:S:N71	S:S:R134	3.62	Yes	Yes	4	7	9
299	S:S:N71	S:S:R148	3.62	Yes	Yes	4	7	7
300	S:S:N71	S:S:T240	7.31	Yes	No	4	7	7
301	S:S:N71	S:S:S327	5.96	Yes	Yes	4	7	4
302	S:S:A153	S:S:I73	3.25	No	Yes	0	7	6
303	S:S:I73	S:S:W154	17.62	Yes	No	0	6	3
304	S:S:T129	S:S:W74	3.64	No	Yes	0	6	7
305	S:S:I130	S:S:W74	15.27	No	Yes	0	8	7
306	S:S:D133	S:S:W74	11.17	No	Yes	0	8	7
307	S:S:A153	S:S:W74	3.89	No	Yes	0	7	7
308	S:S:F75	S:S:Y300	8.25	No	Yes	12	8	9
309	S:S:F75	S:S:L323	15.83	No	Yes	12	8	5
310	S:S:L126	S:S:N77	6.87	No	Yes	17	7	9
311	S:S:N77	S:S:W154	5.65	Yes	No	0	9	3
312	S:S:C157	S:S:N77	11.02	No	Yes	17	6	9
313	S:S:N77	S:S:W161	5.65	Yes	Yes	0	9	9
314	S:S:L127	S:S:L78	4.15	No	No	0	8	9
315	S:S:L84	S:S:V80	2.98	No	No	0	6	5
316	S:S:V80	S:S:W161	3.68	No	Yes	0	5	9
317	S:S:D82	S:S:N119	6.73	Yes	No	5	9	9
318	S:S:C293	S:S:D82	6.22	No	Yes	5	8	9
319	S:S:D82	S:S:N296	5.39	Yes	No	0	9	9
320	S:S:F83	S:S:L87	6.09	No	No	0	8	4
321	S:S:A85	S:S:N119	4.69	No	No	0	6	9
322	S:S:A85	S:S:Y290	4	No	Yes	0	6	7
323	S:S:C86	S:S:L89	3.17	No	Yes	0	5	7
324	S:S:A88	S:S:L112	3.15	No	No	0	6	5
325	S:S:A88	S:S:L115	4.73	No	No	0	6	5
326	S:S:L89	S:S:Y290	15.24	Yes	Yes	5	7	7
327	S:S:A91	S:S:F104	4.16	No	Yes	0	6	7
328	S:S:L92	S:S:Y290	3.52	No	Yes	0	6	7
329	S:S:F93	S:S:V97	3.93	No	No	16	7	3
330	S:S:Q98	S:S:T94	4.25	No	No	0	4	3
331	S:S:F104	S:S:T94	6.49	Yes	No	0	7	3
332	S:S:S95	S:S:W102	4.94	No	Yes	0	4	8
333	S:S:I96	S:S:S283	6.19	No	No	0	5	4
334	S:S:H101	S:S:Q98	6.18	Yes	No	18	4	4
335	S:S:P103	S:S:Q98	3.16	No	No	18	3	4
336	S:S:H100	S:S:S283	4.18	No	No	0	4	4
337	S:S:H101	S:S:P103	6.1	Yes	No	18	4	3
338	S:S:H101	S:S:K185	3.93	Yes	No	0	4	3
339	S:S:H101	S:S:V186	8.3	Yes	No	0	4	6
340	S:S:F104	S:S:W102	16.04	Yes	Yes	0	7	8
341	S:S:C109	S:S:W102	3.92	Yes	Yes	6	9	8
342	S:S:L112	S:S:W102	3.42	No	Yes	0	5	8
343	S:S:P113	S:S:W102	4.05	No	Yes	0	6	8
344	S:S:C188	S:S:W102	15.67	No	Yes	6	9	8
345	S:S:F104	S:S:P103	10.11	Yes	No	0	7	3
346	S:S:A108	S:S:L112	3.15	No	No	0	5	5
347	S:S:C109	S:S:R175	4.18	Yes	Yes	6	9	5
348	S:S:C109	S:S:V177	3.42	Yes	No	0	9	4
349	S:S:C109	S:S:C188	7.28	Yes	No	6	9	9
350	S:S:P113	S:S:R175	12.97	No	Yes	0	6	5
351	S:S:S114	S:S:T168	3.2	Yes	No	0	5	6
352	S:S:S114	S:S:S171	3.26	Yes	No	6	5	5
353	S:S:R175	S:S:S114	6.59	Yes	Yes	6	5	5
354	S:S:I116	S:S:W255	4.7	No	Yes	0	6	9
355	S:S:I116	S:S:Y290	13.3	No	Yes	0	6	7
356	S:S:L117	S:S:S171	4.5	No	No	0	4	5
357	S:S:L117	S:S:R206	7.29	No	No	0	4	6
358	S:S:L118	S:S:L165	5.54	No	No	0	5	4
359	S:S:L118	S:S:T168	7.37	No	No	0	5	6
360	S:S:C293	S:S:N119	4.72	No	No	5	8	9
361	S:S:G210	S:S:M120	3.49	No	No	0	6	7
362	S:S:M120	S:S:W255	11.63	No	Yes	0	7	9
363	S:S:M120	S:S:Q259	4.08	No	Yes	0	7	8
364	S:S:L167	S:S:Y121	11.72	No	No	0	4	7
365	S:S:A122	S:S:W161	3.89	No	Yes	0	6	9
366	S:S:I124	S:S:P214	6.77	No	No	0	8	9
367	S:S:F251	S:S:I124	15.07	Yes	No	0	9	8
368	S:S:A160	S:S:L125	3.15	No	No	0	6	6
369	S:S:L125	S:S:L163	5.54	No	Yes	1	6	4
370	K:K:?1	S:S:L125	7.33	Yes	No	1	0	6
371	S:S:C157	S:S:L126	3.17	No	No	17	6	7
372	S:S:A160	S:S:L126	3.15	No	No	0	6	7
373	S:S:L127	S:S:V247	2.98	No	No	0	8	7
374	S:S:L127	S:S:V248	2.98	No	No	0	8	7
375	K:K:?1	S:S:A128	9.38	Yes	No	0	0	7
376	S:S:L156	S:S:T129	4.42	No	No	1	5	6
377	K:K:?1	S:S:T129	6.83	Yes	No	1	0	6
378	S:S:I130	S:S:V244	4.61	No	No	0	8	7
379	S:S:L218	S:S:S131	3	No	No	0	8	9
380	S:S:S131	S:S:Y222	7.63	No	Yes	0	9	8
381	S:S:D133	S:S:L137	5.43	No	Yes	4	8	8
382	S:S:D133	S:S:R148	13.1	No	Yes	4	8	7
383	S:S:L137	S:S:R134	4.86	Yes	Yes	4	8	9
384	S:S:R134	S:S:T238	3.88	Yes	No	0	9	5
385	S:S:R134	S:S:T240	10.35	Yes	No	4	9	7
386	S:S:R134	S:S:S327	5.27	Yes	Yes	4	9	4
387	S:S:F135	S:S:F139	16.08	No	No	0	8	7
388	S:S:C221	S:S:F135	4.19	No	No	19	6	8
389	S:S:F135	S:S:I225	5.02	No	No	19	8	8
390	S:S:C144	S:S:L137	4.76	No	Yes	4	5	8
391	S:S:L137	S:S:R148	12.15	Yes	Yes	4	8	7
392	S:S:L137	S:S:S327	6.01	Yes	Yes	4	8	4
393	S:S:F139	S:S:V138	10.49	No	No	0	7	8
394	S:S:F139	S:S:R228	11.76	No	No	0	7	5
395	S:S:K140	S:S:W143	16.24	No	No	0	6	5
396	S:S:C144	S:S:R148	4.18	No	Yes	4	5	7
397	S:S:Q145	S:S:V328	4.3	No	No	0	5	4
398	S:S:F147	S:S:R146	13.9	Yes	No	0	4	5
399	S:S:R148	S:S:S327	7.91	Yes	Yes	4	7	4
400	S:S:L152	S:S:L156	5.54	No	No	0	3	5
401	K:K:?1	S:S:L156	5.5	Yes	No	1	0	5
402	K:K:?1	S:S:V159	9.86	Yes	No	0	0	1
403	S:S:G162	W:W:?1	4.53	No	Yes	0	4	0
404	S:S:L163	S:S:L167	4.15	Yes	No	0	4	4
405	S:S:L163	W:W:?1	3.66	Yes	Yes	1	4	0
406	K:K:?1	S:S:L163	4.58	Yes	Yes	1	0	4
407	S:S:L166	W:W:?1	9.16	No	Yes	1	4	0
408	S:S:I169	S:S:P170	3.39	No	No	0	3	8
409	S:S:R175	S:S:S171	3.95	Yes	No	6	5	5
410	S:S:L173	S:S:Y174	3.52	Yes	No	0	4	4
411	S:S:Y174	S:S:Y192	12.91	No	Yes	0	4	5
412	S:S:G189	S:S:R175	3	No	Yes	0	4	5
413	S:S:D191	S:S:V176	5.84	No	No	0	4	4
414	S:S:E180	S:S:R178	8.14	No	No	20	1	2
415	S:S:L187	S:S:R178	10.93	No	No	20	4	2
416	S:S:E179	S:S:Y181	16.83	No	No	0	2	1
417	S:S:E180	S:S:L187	3.98	No	No	20	1	4
418	S:S:F182	S:S:Y181	4.13	No	No	0	3	1
419	S:S:E199	S:S:V190	5.7	No	No	0	4	5
420	S:S:R198	S:S:Y192	8.23	Yes	Yes	0	3	5
421	S:S:E199	S:S:Y192	10.1	No	Yes	0	4	5
422	S:S:H194	S:S:R197	6.77	No	No	11	1	1
423	S:S:H194	S:S:R198	22.57	No	Yes	11	1	3
424	S:S:R197	S:S:R198	3.2	No	Yes	11	1	3
425	S:S:F267	S:S:R200	7.48	No	No	0	4	3
426	S:S:A203	S:S:S266	3.42	No	No	0	5	5
427	S:S:L209	S:S:V205	2.98	No	No	0	4	3
428	S:S:R206	S:S:Y258	5.14	No	No	0	6	7
429	S:S:Q259	S:S:R206	4.67	Yes	No	0	8	6
430	S:S:L207	S:S:L212	6.92	No	No	0	5	4
431	S:S:L207	S:S:Q259	9.32	No	Yes	0	5	8
432	S:S:I263	S:S:L207	8.56	No	No	0	5	5
433	K:K:?1	S:S:L209	8.24	Yes	No	0	0	4
434	S:S:F211	S:S:F252	7.5	No	No	0	8	5
435	S:S:F211	S:S:L256	4.87	No	No	0	8	5
436	S:S:F211	S:S:Q259	8.2	No	Yes	0	8	8
437	S:S:P214	S:S:W213	4.05	No	Yes	1	9	5
438	S:S:T217	S:S:W213	10.92	No	Yes	1	5	5
439	K:K:?1	S:S:W213	21.86	Yes	Yes	1	0	5
440	K:K:?1	S:S:P214	7.61	Yes	No	1	0	9
441	S:S:F252	S:S:L215	10.96	No	No	0	5	5
442	K:K:?1	S:S:T217	4.88	Yes	No	1	0	5
443	S:S:C221	S:S:Y222	4.03	No	Yes	0	6	8
444	S:S:C221	S:S:I225	3.27	No	No	19	6	8
445	S:S:V244	S:S:Y222	3.79	No	Yes	0	7	8
446	S:S:V248	S:S:Y222	3.79	No	Yes	0	7	8
447	S:S:R228	S:S:T235	3.88	No	No	0	5	4
448	S:S:S237	S:S:T229	3.2	No	No	0	7	8
449	S:S:L241	S:S:S237	6.01	Yes	No	0	6	7
450	S:S:K242	S:S:S237	9.18	No	No	0	6	7
451	S:S:E325	S:S:T238	9.88	No	No	0	8	5
452	S:S:E325	S:S:T240	9.88	No	No	0	8	7
453	S:S:L241	S:S:V245	2.98	Yes	No	0	6	4
454	S:S:A246	S:S:I299	3.25	No	No	0	5	7
455	S:S:N296	S:S:V247	8.87	No	No	0	9	7
456	S:S:I295	S:S:S250	4.64	No	No	0	7	6
457	S:S:I299	S:S:S250	3.1	No	No	0	7	6
458	S:S:F251	S:S:F252	9.65	Yes	No	0	9	5
459	S:S:F251	S:S:W255	11.02	Yes	Yes	7	9	9
460	S:S:F251	S:S:N292	3.62	Yes	No	7	9	9
461	S:S:F254	S:S:F288	11.79	Yes	No	7	8	8
462	S:S:F254	S:S:I291	20.09	Yes	No	7	8	5
463	S:S:F254	S:S:N292	6.04	Yes	No	7	8	9
464	S:S:F254	S:S:I295	5.02	Yes	No	0	8	7
465	S:S:W255	S:S:Y258	5.79	Yes	No	0	9	7
466	S:S:A289	S:S:W255	5.19	No	Yes	0	8	9
467	S:S:N292	S:S:W255	10.17	No	Yes	7	9	9
468	S:S:L256	S:S:P257	3.28	No	No	0	5	9
469	S:S:L256	S:S:V260	2.98	No	No	0	5	6
470	S:S:F288	S:S:P257	8.67	No	No	0	8	9
471	S:S:M264	S:S:V260	4.56	No	No	0	4	6
472	S:S:G262	S:S:T261	3.64	No	No	0	5	4
473	S:S:C285	S:S:T261	6.76	No	No	0	6	4
474	S:S:L278	S:S:M264	4.24	Yes	No	0	4	4
475	S:S:F275	S:S:M265	4.98	Yes	No	0	3	4
476	S:S:L278	S:S:M265	4.24	Yes	No	0	4	4
477	S:S:L268	S:S:S272	3	No	Yes	21	2	4
478	S:S:F275	S:S:L268	3.65	Yes	No	21	3	2
479	S:S:E269	S:S:P270	3.14	No	No	0	3	3
480	S:S:F275	S:S:S272	3.96	Yes	Yes	21	3	4
481	S:S:K280	S:S:L276	8.46	No	No	0	2	3
482	S:S:L277	S:S:L281	4.15	No	No	0	1	5
483	S:S:D282	S:S:V286	4.38	No	No	0	4	5
484	S:S:F288	S:S:I291	3.77	No	No	7	8	5
485	S:S:C293	S:S:Y290	4.03	No	Yes	5	8	7
486	S:S:N296	S:S:Y300	9.3	No	Yes	0	9	9
487	S:S:L323	S:S:Y300	14.07	Yes	Yes	12	5	9
488	S:S:L315	S:S:V301	2.98	No	No	0	6	6
489	S:S:G304	S:S:L318	5.13	No	No	0	8	3
490	S:S:L318	S:S:Q305	3.99	No	No	0	3	6
491	S:S:E317	S:S:K313	17.55	No	No	0	3	4
492	S:S:E321	S:S:K313	12.15	No	No	0	6	4
493	S:S:P316	S:S:S314	7.13	No	No	0	5	4
494	S:S:L315	S:S:P316	3.28	No	No	0	6	5
495	S:S:L323	S:S:V322	4.47	Yes	No	0	5	5
496	S:S:R330	S:S:V328	6.54	No	No	0	5	4
497	R:R:L323	R:R:T62	2.95	Yes	No	0	5	6
498	R:R:L215	R:R:T219	2.95	No	No	0	5	4
499	R:R:L227	R:R:T223	2.95	No	No	0	4	2
500	R:R:L278	R:R:T261	2.95	No	No	0	4	4
501	S:S:L215	S:S:T219	2.95	No	No	0	5	4
502	S:S:L227	S:S:T223	2.95	No	No	0	4	2
503	S:S:L278	S:S:T261	2.95	Yes	No	0	4	4
504	S:S:L268	S:S:T274	2.95	No	No	0	2	1
505	S:S:L278	S:S:T274	2.95	Yes	No	0	4	1
506	S:S:D37	S:S:S283	2.94	No	No	0	4	4
507	S:S:I295	S:S:I298	2.94	No	No	0	7	7
508	R:R:Q305	R:R:V301	2.87	No	No	0	6	6
509	S:S:K239	S:S:K242	2.87	No	No	0	7	6
510	S:S:E269	S:S:S272	2.87	No	Yes	0	3	4
511	S:S:Q305	S:S:V301	2.87	No	No	0	6	6
512	S:S:E317	S:S:S314	2.87	No	No	0	3	4
513	R:R:I111	R:R:L115	2.85	No	No	0	4	5
514	R:R:I169	R:R:L173	2.85	No	No	0	3	4
515	S:S:I38	S:S:L33	2.85	No	No	0	5	4
516	S:S:I220	S:S:L216	2.85	No	No	0	3	2
517	S:S:I225	S:S:L241	2.85	No	Yes	0	8	6
518	R:R:Q98	R:R:T94	2.83	No	No	0	4	3
519	R:R:E65	R:R:T69	2.82	No	No	0	5	7
520	R:R:K140	R:R:L136	2.82	No	No	0	6	5
521	R:R:K185	R:R:L187	2.82	No	No	0	3	4
522	S:S:K140	S:S:L136	2.82	No	No	0	6	5
523	R:R:G105	R:R:W102	2.81	No	Yes	0	7	8
524	R:R:A56	R:R:F83	2.77	No	No	0	3	8
525	R:R:L315	R:R:L57	2.77	No	No	0	6	5
526	R:R:L319	R:R:L57	2.77	No	No	0	5	5
527	R:R:A303	R:R:F307	2.77	No	No	0	6	9
528	S:S:L315	S:S:L57	2.77	No	No	0	6	5
529	R:R:E321	R:R:K239	2.7	No	No	0	6	7
530	R:R:E321	R:R:K313	2.7	No	No	0	6	4
531	S:S:F251	S:S:S123	2.64	Yes	No	0	9	9
532	S:S:R200	S:S:S266	2.64	No	No	0	3	5
533	R:R:F75	R:R:V243	2.62	No	No	0	8	7
534	S:S:F83	S:S:V52	2.62	No	No	0	8	5
535	S:S:R320	S:S:V61	2.62	No	No	0	6	6
536	S:S:F75	S:S:V243	2.62	No	No	0	8	7
537	S:S:R148	S:S:V328	2.62	Yes	No	0	7	4
538	R:R:A81	R:R:W161	2.59	No	Yes	0	8	9
539	R:R:A108	R:R:W102	2.59	No	Yes	0	5	8
540	S:S:A81	S:S:W161	2.59	No	Yes	0	8	9
541	S:S:R236	S:S:T238	2.59	No	No	0	5	5
542	S:S:V47	S:S:Y290	2.52	No	Yes	0	6	7
543	S:S:V202	S:S:Y192	2.52	No	Yes	0	5	5
544	S:S:V286	S:S:Y258	2.52	No	No	0	5	7
545	S:S:V286	S:S:Y290	2.52	No	Yes	0	5	7
546	R:R:F224	R:R:I220	2.51	No	No	0	3	3
547	S:S:F44	S:S:I96	2.51	Yes	No	0	7	5
548	S:S:F224	S:S:I220	2.51	No	No	0	3	3
549	S:S:S231	S:S:W230	2.47	No	No	0	4	4
550	R:R:F48	R:R:L49	2.44	Yes	No	0	6	4
551	R:R:L92	R:R:W102	2.28	No	Yes	0	6	8
552	S:S:L216	S:S:W213	2.28	No	Yes	0	2	5
553	R:R:F139	R:R:F224	2.14	Yes	No	0	7	3
554	R:R:G105	R:R:G106	2.11	No	No	0	7	3
555	S:S:G105	S:S:G106	2.11	No	No	0	7	3
556	R:R:C86	R:R:G51	1.96	No	No	0	5	8
557	R:R:C294	R:R:G51	1.96	No	No	0	7	8
558	S:S:C109	S:S:G106	1.96	Yes	No	0	9	3
559	R:R:A150	R:R:G151	1.95	No	No	0	3	4
560	R:R:P183	R:R:P184	1.95	No	No	0	4	5
561	R:R:A303	R:R:G304	1.95	No	No	0	6	8
562	S:S:A150	S:S:G151	1.95	No	No	0	3	4
563	S:S:P183	S:S:P184	1.95	No	No	0	4	5
564	K:K:?1	R:R:I155	1.89	Yes	No	0	0	2
565	S:S:G304	S:S:V322	1.84	No	No	0	8	5
566	R:R:G262	R:R:T261	1.82	No	No	0	5	4
567	R:R:A122	R:R:A164	1.79	No	No	0	6	7
568	S:S:A122	S:S:A164	1.79	No	No	0	6	7
569	S:S:P273	S:S:S272	1.78	No	Yes	0	2	4
570	R:R:G149	R:R:I70	1.76	No	Yes	0	5	6
571	S:S:G149	S:S:I70	1.76	No	Yes	0	5	6
572	R:R:G210	R:R:M120	1.75	No	No	0	6	7
573	R:R:G54	R:R:L53	1.71	No	No	0	7	4
574	S:S:G54	S:S:L53	1.71	No	No	0	7	4
575	S:S:A172	S:S:S114	1.71	No	Yes	0	4	5
576	S:S:A303	S:S:V243	1.7	No	No	0	6	7
577	S:S:A303	S:S:V322	1.7	No	No	0	6	5
578	R:R:A72	R:R:T69	1.68	No	No	0	7	7
579	R:R:A72	R:R:T324	1.68	No	No	0	7	5
580	S:S:A232	S:S:T235	1.68	No	No	0	5	4
581	R:R:K140	R:R:P141	1.67	No	No	0	6	8
582	S:S:K140	S:S:P141	1.67	No	No	0	6	8
583	S:S:K185	S:S:P183	1.67	No	No	0	3	4
584	R:R:G306	R:R:Q305	1.64	No	No	0	7	6
585	R:R:A66	R:R:I73	1.62	No	No	0	5	6
586	R:R:A150	R:R:I73	1.62	No	No	0	3	6
587	R:R:A203	R:R:I263	1.62	No	No	0	5	5
588	S:S:A66	S:S:I73	1.62	No	Yes	0	5	6
589	S:S:A150	S:S:I70	1.62	No	Yes	0	3	6
590	S:S:A150	S:S:I73	1.62	No	Yes	0	3	6
591	S:S:A203	S:S:I263	1.62	No	No	0	5	5
592	R:R:V42	R:R:V46	1.6	No	No	0	5	4
593	R:R:V46	R:R:V50	1.6	No	No	0	4	6
594	R:R:S114	R:R:T168	1.6	No	No	0	5	6
595	S:S:V46	S:S:V50	1.6	No	No	0	4	6
596	R:R:C144	R:R:L136	1.59	No	No	0	5	5
597	S:S:C144	S:S:L136	1.59	No	No	0	5	5
598	R:R:A63	R:R:L76	1.58	No	No	0	3	6
599	R:R:A164	R:R:L118	1.58	No	No	0	7	5
600	R:R:A201	S:S:L173	1.58	No	Yes	0	4	4
601	R:R:T219	R:R:T223	1.57	No	No	0	4	2
602	S:S:T219	S:S:T223	1.57	No	No	0	4	2
603	R:R:I204	R:R:V208	1.54	No	No	0	3	4
604	R:R:I298	R:R:V302	1.54	No	No	0	7	6
605	S:S:I155	S:S:V159	1.54	No	No	0	2	1
606	S:S:I204	S:S:V208	1.54	No	No	0	3	4
607	S:S:I298	S:S:V302	1.54	No	No	0	7	6
608	R:R:L137	R:R:V328	1.49	Yes	No	0	8	4
609	R:R:L226	R:R:T229	1.47	No	No	0	5	8
610	R:R:P36	R:R:R34	1.44	Yes	No	0	3	2
611	S:S:E269	S:S:S271	1.44	No	No	0	3	4
612	R:R:I38	R:R:L33	1.43	No	No	0	5	4
613	S:S:I111	S:S:L115	1.43	No	No	0	4	5
614	R:R:E326	R:R:T69	1.41	No	No	0	5	7
615	R:R:G162	R:R:W161	1.41	No	Yes	0	4	9
616	S:S:K185	S:S:L187	1.41	No	No	0	3	4
617	S:S:A56	S:S:F83	1.39	No	No	0	3	8
618	S:S:H194	S:S:S193	1.39	No	No	0	1	4
619	R:R:A142	S:S:R146	1.38	No	No	0	5	5
620	S:S:L33	S:S:L41	1.38	No	Yes	0	4	5
621	S:S:L226	S:S:L241	1.38	No	Yes	0	5	6
622	R:R:V190	R:R:Y174	1.26	No	Yes	0	5	4
623	R:R:D195	R:R:H194	1.26	No	No	0	3	1
624	R:R:F275	R:R:K279	1.24	Yes	No	0	3	4
625	S:S:K196	S:S:R200	1.24	No	No	0	2	3
626	S:S:F275	S:S:K279	1.24	Yes	No	0	3	4
627	S:S:V61	S:S:W60	1.23	No	No	0	6	4
628	S:S:V208	S:S:W213	1.23	No	Yes	0	4	5
629	S:S:F48	S:S:L49	1.22	Yes	No	0	6	4
630	R:R:E234	R:R:R233	1.16	No	No	0	2	4
631	S:S:E234	S:S:R233	1.16	No	No	0	2	4
632	R:R:L57	R:R:W60	1.14	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P36	2.95	5	0	3
2	R:R:F44	5.746	5	2	7
3	R:R:F48	4.9425	4	0	6
4	R:R:I70	6.7525	4	3	6
5	R:R:N71	5.0625	4	3	7
6	R:R:W74	8.21	5	3	7
7	R:R:N77	7.2975	4	13	9
8	R:R:D82	6.2675	4	2	9
9	R:R:L89	7.025	4	2	7
10	R:R:I96	4.1675	4	2	5
11	R:R:H101	5.765	4	15	4
12	R:R:W102	5.68571	7	14	8
13	R:R:N119	4.972	5	2	9
14	R:R:L126	4.335	4	13	7
15	R:R:R134	5.24333	6	3	9
16	R:R:L137	5.44	6	3	8
17	R:R:F139	10.1175	4	0	7
18	R:R:F147	12.6175	4	8	4
19	R:R:R148	10.096	5	3	7
20	R:R:W161	3.444	5	0	9
21	R:R:Y174	7.535	4	0	4
22	R:R:F211	5.5075	4	0	8
23	R:R:Y222	4.828	5	0	8
24	R:R:V247	4.5375	4	10	7
25	R:R:S250	3.4875	4	10	6
26	R:R:F254	10.544	5	0	8
27	R:R:W255	9.944	5	0	9
28	R:R:F275	3.9125	4	0	3
29	R:R:S287	6.3975	4	0	4
30	R:R:Y290	8.10333	6	2	7
31	R:R:I299	4.195	4	10	7
32	R:R:Y300	8.595	4	9	9
33	R:R:L323	8.656	5	9	5
34	R:R:S327	6.2875	4	3	4
35	S:S:P36	3.3275	4	0	3
36	S:S:L41	6.58	4	16	5
37	S:S:F44	5.4475	4	5	7
38	S:S:F48	6.875	4	0	6
39	S:S:V58	3.705	4	12	8
40	S:S:I70	6.6575	4	0	6
41	S:S:N71	4.78	5	4	7
42	S:S:I73	6.0275	4	0	6
43	S:S:W74	7.59667	6	0	7
44	S:S:N77	7.2975	4	17	9
45	S:S:D82	6.605	4	5	9
46	S:S:L89	8.255	4	5	7
47	S:S:H101	6.1275	4	18	4
48	S:S:W102	8.00667	6	6	8
49	S:S:F104	9.2	4	0	7
50	S:S:C109	4.152	5	6	9
51	S:S:S114	3.69	4	6	5
52	S:S:R134	5.596	5	4	9
53	S:S:L137	6.642	5	4	8
54	S:S:F147	8.2275	4	8	4
55	S:S:R148	8.37286	7	4	7
56	S:S:W161	3.9525	4	0	9
57	S:S:L163	4.4825	4	1	4
58	S:S:L173	2.765	4	0	4
59	S:S:R175	6.138	5	6	5
60	S:S:Y192	8.44	4	0	5
61	S:S:R198	12.484	5	11	3
62	S:S:W213	8.068	5	1	5
63	S:S:Y222	4.81	4	0	8
64	S:S:L241	3.305	4	0	6
65	S:S:F251	8.4	5	7	9
66	S:S:F254	10.735	4	7	8
67	S:S:W255	8.08333	6	7	9
68	S:S:Q259	6.5675	4	0	8
69	S:S:S272	2.9025	4	21	4
70	S:S:F275	3.4575	4	21	3
71	S:S:L278	3.595	4	0	4
72	S:S:Y290	6.28625	8	5	7
73	S:S:Y300	8.8525	4	12	9
74	S:S:L323	9.71	4	12	5
75	S:S:S327	6.2875	4	4	4
76	W:W:?1	7.04308	13	1	0
77	K:K:?1	8.23333	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F44	R:R:Y290	14.3593	7.22	Yes	Yes	2	7	7
2	R:R:C293	R:R:Y290	38.3155	4.03	No	Yes	2	8	7
3	R:R:C293	R:R:D82	38.748	6.22	No	Yes	2	8	9
4	R:R:D82	R:R:N296	43.9089	6.73	Yes	No	0	9	9
5	R:R:N296	R:R:V247	52.8647	8.87	No	Yes	0	9	7
6	R:R:L127	R:R:V247	20.0715	2.98	No	Yes	0	8	7
7	R:R:R134	R:R:T238	11.7022	3.88	Yes	No	0	9	5
8	R:R:E325	R:R:T238	11.1747	9.88	No	No	0	8	5
9	R:R:E325	R:R:K239	37.9605	4.05	No	No	0	8	7
10	R:R:E321	R:R:K239	28.5137	2.7	No	No	0	6	7
11	R:R:E321	R:R:K313	26.6208	2.7	No	No	0	6	4
12	R:R:E317	R:R:K313	24.7268	5.4	No	No	0	3	4
13	R:R:E317	R:R:S314	22.8317	5.75	No	No	0	3	4
14	R:R:P316	R:R:S314	20.9354	5.34	No	No	0	5	4
15	R:R:L315	R:R:P316	19.0379	3.28	No	No	0	6	5
16	R:R:L315	R:R:L57	11.4364	2.77	No	No	0	6	5
17	R:R:R134	R:R:T240	11.6941	7.76	Yes	No	3	9	7
18	R:R:E325	R:R:T240	28.6723	9.88	No	No	0	8	7
19	R:R:I70	R:R:W74	11.5175	8.22	Yes	Yes	3	6	7
20	R:R:I70	R:R:R148	10.6113	13.78	Yes	Yes	3	6	7
21	R:R:D133	R:R:W74	37.2622	11.17	No	Yes	3	8	7
22	R:R:D133	R:R:R148	10.4943	16.68	No	Yes	3	8	7
23	R:R:N71	R:R:R148	19.2898	4.82	Yes	Yes	3	7	7
24	R:R:L137	R:R:R134	24.1687	6.07	Yes	Yes	3	8	9
25	R:R:L127	R:R:L78	13.8735	4.15	No	No	0	8	9
26	R:R:L126	R:R:L78	13.3171	4.15	Yes	No	0	7	9
27	R:R:L126	R:R:N77	11.6032	6.87	Yes	Yes	13	7	9
28	R:R:S250	R:R:V247	56.827	3.23	Yes	Yes	10	6	7
29	R:R:N292	R:R:S250	56.4663	2.98	No	Yes	0	9	6
30	R:R:N292	R:R:W255	57.3551	7.91	No	Yes	0	9	9
31	R:R:F251	R:R:W255	60.3076	10.02	No	Yes	0	9	9
32	R:R:F251	R:R:I124	79.5006	15.07	No	No	0	9	8
33	R:R:I124	R:R:P214	79.8903	5.08	No	No	0	8	9
34	R:R:P214	W:W:?1	80.0617	5.43	No	Yes	1	9	0
35	R:R:T129	W:W:?1	56.2266	5.85	No	Yes	0	6	0
36	R:R:L92	R:R:W102	14.6054	2.28	No	Yes	0	6	8
37	R:R:L92	R:R:Y290	15.1746	3.52	No	Yes	0	6	7
38	R:R:V159	W:W:?1	66.2009	9.86	No	Yes	0	1	0
39	K:K:?1	R:R:V159	66.1865	10.84	Yes	No	0	0	1
40	K:K:?1	S:S:L163	66.5785	4.58	Yes	Yes	1	0	4
41	S:S:L163	W:W:?1	69.1256	3.66	Yes	Yes	1	4	0
42	R:R:L209	W:W:?1	17.5243	3.66	No	Yes	1	4	0
43	R:R:L209	R:R:V205	16.9887	2.98	No	No	0	4	3
44	R:R:V205	S:S:L173	15.2783	2.98	No	Yes	0	3	4
45	S:S:L173	S:S:Y174	12.9824	3.52	Yes	No	0	4	4
46	R:R:F251	R:R:F252	22.8074	8.57	No	No	0	9	5
47	R:R:F211	R:R:F252	20.0251	6.43	Yes	No	0	8	5
48	R:R:L256	R:R:V260	12.1637	2.98	No	No	0	5	6
49	R:R:M264	R:R:V260	11.4121	4.56	No	No	0	4	6
50	R:R:L278	R:R:M264	10.6593	5.65	No	No	0	4	4
51	K:K:?1	S:S:P214	99.5339	7.61	Yes	No	1	0	9
52	S:S:I124	S:S:P214	100	6.77	No	No	0	8	9
53	S:S:F251	S:S:I124	99.6155	15.07	Yes	No	0	9	8
54	S:S:F251	S:S:W255	75.6779	11.02	Yes	Yes	7	9	9
55	S:S:I116	S:S:W255	41.6281	4.7	No	Yes	0	6	9
56	S:S:I116	S:S:Y290	41.1336	13.3	No	Yes	0	6	7
57	S:S:F44	S:S:Y290	14.5157	5.16	Yes	Yes	5	7	7
58	S:S:F44	S:S:I96	12.1341	2.51	Yes	No	0	7	5
59	S:S:C293	S:S:Y290	24.3829	4.03	No	Yes	5	8	7
60	S:S:C293	S:S:D82	23.2984	6.22	No	Yes	5	8	9
61	K:K:?1	S:S:T129	47.7762	6.83	Yes	No	1	0	6
62	S:S:T129	S:S:W74	47.4971	3.64	No	Yes	0	6	7
63	S:S:I130	S:S:W74	29.0383	15.27	No	Yes	0	8	7
64	S:S:I130	S:S:V244	28.5131	4.61	No	No	0	8	7
65	S:S:V244	S:S:Y222	28.0117	3.79	No	Yes	0	7	8
66	S:S:V248	S:S:Y222	20.2573	3.79	No	Yes	0	7	8
67	S:S:L127	S:S:V248	19.8856	2.98	No	No	0	8	7
68	S:S:L127	S:S:V247	19.1687	2.98	No	No	0	8	7
69	S:S:N296	S:S:V247	18.8132	8.87	No	No	0	9	7
70	S:S:N296	S:S:Y300	33.6757	9.3	No	Yes	0	9	9
71	S:S:L323	S:S:Y300	24.2242	14.07	Yes	Yes	12	5	9
72	S:S:L323	S:S:V322	23.2596	4.47	Yes	No	0	5	5
73	S:S:G304	S:S:V322	21.1803	1.84	No	No	0	8	5
74	S:S:G304	S:S:L318	20.1322	5.13	No	No	0	8	3
75	S:S:L318	S:S:Q305	19.083	3.99	No	No	0	3	6
76	S:S:Q305	S:S:V301	18.0327	2.87	No	No	0	6	6
77	S:S:L315	S:S:V301	16.9812	2.98	No	No	0	6	6
78	S:S:L315	S:S:L57	10.6478	2.77	No	No	0	6	5
79	S:S:D82	S:S:N296	20.5833	5.39	Yes	No	0	9	9
80	S:S:W255	S:S:Y258	30.4558	5.79	Yes	No	0	9	7
81	S:S:R206	S:S:Y258	34.2304	5.14	No	No	0	6	7
82	S:S:L117	S:S:R206	33.3341	7.29	No	No	0	4	6
83	S:S:L117	S:S:S171	32.7817	4.5	No	No	0	4	5
84	S:S:R175	S:S:S171	29.2983	3.95	Yes	No	6	5	5
85	S:S:C109	S:S:R175	15.3425	4.18	Yes	Yes	6	9	5
86	S:S:C109	S:S:W102	12.441	3.92	Yes	Yes	6	9	8
87	S:S:P113	S:S:R175	12.9824	12.97	No	Yes	0	6	5
88	S:S:P113	S:S:W102	12.4051	4.05	No	Yes	0	6	8
89	S:S:F104	S:S:W102	16.6257	16.04	Yes	Yes	0	7	8
90	S:S:F104	S:S:P103	11.8875	10.11	Yes	No	0	7	3
91	S:S:F251	S:S:F252	20.5798	9.65	Yes	No	0	9	5
92	S:S:F211	S:S:F252	18.0408	7.5	No	No	0	8	5
93	S:S:F211	S:S:L256	15.987	4.87	No	No	0	8	5
94	S:S:L256	S:S:V260	14.8341	2.98	No	No	0	5	6
95	S:S:M264	S:S:V260	14.1393	4.56	No	No	0	4	6
96	S:S:L278	S:S:M264	13.4433	4.24	Yes	No	0	4	4
97	S:S:C144	S:S:L136	10.2482	1.59	No	No	0	5	5
98	R:R:N71	R:R:T240	18.3303	5.85	Yes	No	3	7	7
99	R:R:D133	R:R:L137	26.3116	5.43	No	Yes	3	8	8
100	R:R:T129	R:R:W74	55.8259	4.85	No	Yes	0	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V159	W:W:?1	9.86	0	No	Yes	1	0	1	2
K:K:?1	R:R:V159	10.84	1	Yes	No	0	1	0	1
S:S:T129	S:S:W74	3.64	1	No	Yes	6	7	1	2
S:S:I124	S:S:P214	6.77	0	No	No	8	9	2	1
S:S:A160	S:S:L125	3.15	0	No	No	6	6	2	1
S:S:L125	S:S:L163	5.54	1	No	Yes	6	4	1	1
K:K:?1	S:S:L125	7.33	1	Yes	No	0	6	0	1
K:K:?1	S:S:A128	9.38	1	Yes	No	0	7	0	1
S:S:L156	S:S:T129	4.42	1	No	No	5	6	1	1
K:K:?1	S:S:T129	6.83	1	Yes	No	0	6	0	1
S:S:L152	S:S:L156	5.54	0	No	No	3	5	2	1
K:K:?1	S:S:L156	5.5	1	Yes	No	0	5	0	1
K:K:?1	S:S:V159	9.86	1	Yes	No	0	1	0	1
S:S:L163	S:S:L167	4.15	1	Yes	No	4	4	1	2
S:S:L163	W:W:?1	3.66	1	Yes	Yes	4	0	1	2
K:K:?1	S:S:L163	4.58	1	Yes	Yes	0	4	0	1
S:S:L209	S:S:V205	2.98	0	No	No	4	3	1	2
K:K:?1	S:S:L209	8.24	1	Yes	No	0	4	0	1
S:S:P214	S:S:W213	4.05	1	No	Yes	9	5	1	1
S:S:T217	S:S:W213	10.92	1	No	Yes	5	5	1	1
K:K:?1	S:S:W213	21.86	1	Yes	Yes	0	5	0	1
K:K:?1	S:S:P214	7.61	1	Yes	No	0	9	0	1
K:K:?1	S:S:T217	4.88	1	Yes	No	0	5	0	1
S:S:L216	S:S:W213	2.28	0	No	Yes	2	5	2	1
K:K:?1	R:R:I155	1.89	1	Yes	No	0	2	0	1
S:S:I155	S:S:V159	1.54	0	No	No	2	1	2	1
S:S:V208	S:S:W213	1.23	0	No	Yes	4	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:T129	R:R:W74	4.85	0	No	Yes	6	7	1	2
R:R:I124	R:R:P214	5.08	0	No	No	8	9	2	1
R:R:L125	R:R:L163	5.54	1	No	No	6	4	1	1
R:R:L125	W:W:?1	8.24	1	No	Yes	6	0	1	0
R:R:A128	W:W:?1	9.38	0	No	Yes	7	0	1	0
R:R:T129	W:W:?1	5.85	0	No	Yes	6	0	1	0
R:R:L152	R:R:L156	4.15	0	No	No	3	5	2	1
R:R:L156	W:W:?1	3.66	0	No	Yes	5	0	1	0
R:R:V159	W:W:?1	9.86	0	No	Yes	1	0	1	0
K:K:?1	R:R:V159	10.84	1	Yes	No	0	1	2	1
R:R:L163	S:S:L166	4.15	1	No	No	4	4	1	1
R:R:L163	W:W:?1	3.66	1	No	Yes	4	0	1	0
R:R:L209	R:R:V205	2.98	1	No	No	4	3	1	2
R:R:L209	S:S:L166	4.15	1	No	No	4	4	1	1
R:R:L209	W:W:?1	3.66	1	No	Yes	4	0	1	0
R:R:P214	R:R:W213	4.05	1	No	No	9	5	1	1
R:R:T217	R:R:W213	10.92	1	No	No	5	5	1	1
R:R:W213	W:W:?1	19.59	1	No	Yes	5	0	1	0
R:R:P214	W:W:?1	5.43	1	No	Yes	9	0	1	0
R:R:T217	W:W:?1	4.88	1	No	Yes	5	0	1	0
S:S:L125	S:S:L163	5.54	1	No	Yes	6	4	2	1
K:K:?1	S:S:L125	7.33	1	Yes	No	0	6	2	2
S:S:G162	W:W:?1	4.53	0	No	Yes	4	0	1	0
S:S:L163	S:S:L167	4.15	1	Yes	No	4	4	1	2
S:S:L163	W:W:?1	3.66	1	Yes	Yes	4	0	1	0
K:K:?1	S:S:L163	4.58	1	Yes	Yes	0	4	2	1
S:S:L166	W:W:?1	9.16	1	No	Yes	4	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	5O9H_poly
Class	A
SubFamily	Peptide
Type	Complement peptide
SubType	C5a1
Species	Homo sapiens
Ligand	-
Other Ligand(s)	NDT9513727
Protein Partners	-
PDB Resolution	2.7
Date	2018-01-10
D.O.I.	10.1038/nature25025

Net Summary
I_min	2.98
Number of Linked Nodes	558
Number of Links	632
Number of Hubs	77
Number of Links mediated by Hubs	311
Number of Communities	21
Number of Nodes involved in Communities	112
Number of Links involved in Communities	145

Path Summary
Number Of Nodes in MetaPath	101
Number Of Links MetaPath	100
Number of Shortest Paths	359508
Length Of Smallest Path	3
Average Path Length	20.8723
Length of Longest Path	47
Minimum Path Strength	1.385
Average Path Strength	6.57599
Maximum Path Strength	20.03
Minimum Path Correlation	0.7
Average Path Correlation	0.963021
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	47.3004
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.3306
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	9P2
PDB Residues	W:W:?1 K:K:?1
Environment Details	Open EMBL-EBI Page
Code	9P2
Name	1-(1,3-benzodioxol-5-yl)-~{N}-(1,3-benzodioxol-5-ylmethyl)-~{N}-[(3-butyl-2,5-diphenyl-imidazol-4-yl)methyl]methanamine
Synonyms
Identifier	1-(1,3-benzodioxol-5-yl)-~{N}-(1,3-benzodioxol-5-ylmethyl)-~{N}-[(3-butyl-2,5-diphenyl-imidazol-4-yl)methyl]methanamine
Formula	C36 H35 N3 O4
Molecular Weight	573.681
SMILES	CCCCn1c(c(nc1c2ccccc2)c3ccccc3)CN(Cc4ccc5c(c4)OCO5)Cc6ccc7c(c6)OCO7
PubChem	10210160
Formal Charge	0
Total Atoms	78
Total Chiral Atoms	0
Total Bonds	84
Total Aromatic Bonds	29


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21730
Sequence	>5O9H_poly_Chain_R N T L R V P D I L A L V I F A V V F L V G V L G N A L V V W V T A F E A K R T I N A I W F L N L A V A D F L A C L A L P A L F T S I V Q H H H W P F G G A A C S I L P S L I L L N M Y A S I L L L A T I S A D R F L L V F K P A W C Q R F R G A G L A W I L C A V A W G L A L L L T I P S A L Y R V V R E E Y F P P K V L C G V D H D K R R E R A V A I V R L V L G F L W P L L T L T I C Y T F I L L R T W S A R E T R S T K T L K V V V A V V A S F F I F W L P Y Q V T G I M M S F L E P S S P T F L L L K K L D S L C V S F A Y I N C C I N P I I Y V V A G Q G F Q K S L P E L L R E V L T E E S V V R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5O9H	A	Peptide	Complement peptide	C5a₁	Homo sapiens	-	NDT9513727	-	2.7	2018-01-10	10.1038/nature25025
	6C1Q	A	Peptide	Complement peptide	C5a₁	Homo sapiens	PMX53	NDT9513727	-	2.9	2018-05-30	10.1038/s41594-018-0067-z
	6C1R	A	Peptide	Complement peptide	C5a₁	Homo sapiens	PMX53	Avacopan; Na	-	2.2	2018-05-30	10.1038/s41594-018-0067-z
	8HPT	A	Peptide	Complement peptide	C5a₁	Mus musculus	C5a anaphylatoxin C-terminal peptide	-	Go/&β;1/&γ;2	3.39	2023-10-18	10.1016/j.cell.2023.09.020
	8HQC	A	Peptide	Complement peptide	C5a₁	Mus musculus	C5a anaphylatoxin	-	Go/&β;1/&γ;2	3.89	2023-10-18	10.1016/j.cell.2023.09.020
	8IA2	A	Peptide	Complement peptide	C5a₁	Homo sapiens	C5a anaphylatoxin	-	Go/&β;1/&γ;2	3.21	2023-10-18	10.1016/j.cell.2023.09.020
	8JZZ	A	Peptide	Complement peptide	C5a₁	Homo sapiens	C5a-desArg	-	Go/&β;1/&γ;2	3.31	2023-10-18	10.1016/j.cell.2023.09.020
	5O9H (Dimer)	A	Peptide	Complement peptide	C5a₁	Homo sapiens	-	NDT9513727	-	2.7	2018-01-10	10.1038/nature25025

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 5O9H_poly.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.