psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:N98	8.72	Yes	Yes	1	0	7
2	L:L:?1	R:R:M121	4.49	Yes	No	1	0	7
3	L:L:?1	R:R:Y176	8.68	Yes	Yes	1	0	7
4	L:L:?1	R:R:R197	6.43	Yes	Yes	0	0	4
5	L:L:?1	R:R:N333	10.17	Yes	No	0	0	7
6	L:L:?1	R:R:R336	36	Yes	No	0	0	4
7	L:L:?1	R:R:L347	10.25	Yes	No	0	0	5
8	L:L:?1	R:R:I352	16.62	Yes	No	1	0	5
9	L:L:?1	R:R:L356	13.18	Yes	No	1	0	6
10	L:L:?1	R:R:S359	4.77	Yes	No	0	0	7
11	R:R:Q44	R:R:Y48	4.51	No	Yes	2	4	7
12	R:R:L103	R:R:Q44	3.99	No	No	2	5	4
13	R:R:I51	R:R:L47	5.71	Yes	No	0	7	5
14	R:R:M95	R:R:Y48	7.18	Yes	Yes	2	7	7
15	R:R:L99	R:R:Y48	5.86	No	Yes	0	6	7
16	R:R:I100	R:R:Y48	3.63	Yes	Yes	2	5	7
17	R:R:L103	R:R:Y48	10.55	No	Yes	2	5	7
18	R:R:L357	R:R:Y48	11.72	No	Yes	2	7	7
19	R:R:L50	R:R:L54	6.92	No	No	0	4	5
20	R:R:I51	R:R:L357	4.28	Yes	No	2	7	7
21	R:R:I51	R:R:Y360	3.63	Yes	Yes	2	7	7
22	R:R:F52	R:R:V56	7.87	Yes	No	0	5	6
23	R:R:F52	R:R:M95	7.46	Yes	Yes	2	5	7
24	R:R:F52	R:R:Y360	4.13	Yes	Yes	2	5	7
25	R:R:C364	R:R:S55	5.16	No	No	0	7	8
26	R:R:L88	R:R:V56	4.47	No	No	0	7	6
27	R:R:D87	R:R:N59	12.12	No	No	0	9	9
28	R:R:L88	R:R:N59	4.12	No	No	0	7	9
29	R:R:N59	R:R:P367	8.15	No	No	0	9	9
30	R:R:F372	R:R:L61	3.65	Yes	No	0	6	7
31	R:R:C371	R:R:V62	8.54	No	No	0	8	9
32	R:R:F372	R:R:V62	3.93	Yes	No	0	6	9
33	R:R:I63	R:R:L81	4.28	No	No	0	7	6
34	R:R:F377	R:R:V65	7.87	No	No	0	9	8
35	R:R:G380	R:R:V65	5.52	No	No	0	8	8
36	R:R:L66	R:R:N77	4.12	No	No	0	7	9
37	R:R:L66	R:R:L81	4.15	No	No	0	7	6
38	R:R:I67	R:R:L81	5.71	No	No	0	3	6
39	R:R:N69	R:R:R71	16.87	Yes	No	3	6	6
40	R:R:M72	R:R:N69	4.21	No	Yes	3	8	6
41	R:R:L379	R:R:N69	10.98	Yes	Yes	3	5	6
42	R:R:M382	R:R:N69	5.61	Yes	Yes	3	5	6
43	R:R:K70	R:R:R73	16.09	No	No	0	7	8
44	R:R:M382	R:R:R71	9.93	Yes	No	3	5	6
45	R:R:M72	R:R:N77	7.01	No	No	0	8	9
46	R:R:L379	R:R:M72	4.24	Yes	No	3	5	8
47	R:R:N77	R:R:T74	10.24	No	No	0	9	7
48	R:R:E138	R:R:V75	8.56	No	No	4	9	7
49	R:R:Q153	R:R:V75	5.73	Yes	No	4	7	7
50	R:R:A158	R:R:I78	4.87	No	No	0	7	5
51	R:R:I78	R:R:L159	4.28	No	No	0	5	5
52	R:R:A134	R:R:F79	4.16	No	Yes	0	8	8
53	R:R:F79	R:R:I135	3.77	Yes	No	0	8	9
54	R:R:E138	R:R:F79	11.66	No	Yes	0	9	8
55	R:R:F79	R:R:V161	5.24	Yes	No	0	8	6
56	R:R:F79	R:R:I162	7.54	Yes	No	0	8	7
57	R:R:L80	R:R:Y370	3.52	No	Yes	0	8	9
58	R:R:C371	R:R:L80	6.35	No	No	0	8	8
59	R:R:N131	R:R:S82	8.94	No	No	0	8	9
60	R:R:I162	R:R:S82	6.19	No	No	0	7	9
61	R:R:S82	R:R:W166	6.18	No	No	0	9	9
62	R:R:L132	R:R:L83	4.15	No	No	0	8	9
63	R:R:L83	R:R:N366	8.24	No	No	0	9	9
64	R:R:S86	R:R:V127	4.85	No	No	0	8	8
65	R:R:D87	R:R:S363	4.42	No	Yes	0	9	9
66	R:R:D87	R:R:N366	12.12	No	No	0	9	9
67	R:R:F93	R:R:M89	4.98	No	No	8	5	7
68	R:R:F120	R:R:M89	3.73	Yes	No	8	5	7
69	R:R:M89	R:R:S124	7.67	No	No	0	7	6
70	R:R:C94	R:R:L90	4.76	No	No	0	7	8
71	R:R:F93	R:R:T117	3.89	No	No	0	5	6
72	R:R:F120	R:R:F93	9.65	Yes	No	8	5	5
73	R:R:C94	R:R:M121	4.86	No	No	0	7	7
74	R:R:I100	R:R:M95	5.83	Yes	Yes	2	5	7
75	R:R:M95	R:R:Y360	9.58	Yes	Yes	2	7	7
76	R:R:F97	R:R:P96	14.45	No	No	0	6	8
77	R:R:F97	R:R:T117	7.78	No	No	0	6	6
78	R:R:L99	R:R:N98	5.49	No	Yes	0	6	7
79	R:R:N102	R:R:N98	4.09	No	Yes	0	6	7
80	R:R:M121	R:R:N98	5.61	No	Yes	1	7	7
81	R:R:F107	R:R:P101	8.67	No	No	0	8	5
82	R:R:K105	R:R:T186	4.5	No	No	0	4	3
83	R:R:D106	R:R:I108	4.2	No	No	0	4	4
84	R:R:D106	R:R:K187	6.91	No	No	0	4	2
85	R:R:F107	R:R:F109	28.94	No	Yes	5	8	6
86	R:R:C196	R:R:F107	5.59	No	No	5	9	8
87	R:R:C114	R:R:F109	4.19	No	Yes	5	9	6
88	R:R:F109	R:R:N181	12.08	Yes	Yes	0	6	5
89	R:R:C196	R:R:F109	5.59	No	Yes	5	9	6
90	R:R:G110	R:R:V113	3.68	No	No	0	7	5
91	R:R:C114	R:R:C196	7.28	No	No	5	9	9
92	R:R:F120	R:R:T116	5.19	Yes	No	0	5	4
93	R:R:T118	R:R:Y176	8.74	No	Yes	1	6	7
94	R:R:T118	R:R:Y179	24.97	No	No	1	6	5
95	R:R:F120	R:R:Y119	11.35	Yes	No	0	5	6
96	R:R:F170	R:R:Y119	6.19	No	No	0	4	6
97	R:R:G122	R:R:Y176	5.79	No	Yes	0	6	7
98	R:R:F170	R:R:T123	11.67	No	No	0	4	6
99	R:R:V125	R:R:W326	7.36	No	Yes	0	7	8
100	R:R:I172	R:R:S126	4.64	Yes	No	1	6	7
101	R:R:M173	R:R:S126	4.6	Yes	No	1	8	7
102	R:R:L217	R:R:S126	7.51	No	No	0	7	7
103	R:R:V127	R:R:W166	14.71	No	No	0	8	9
104	R:R:S169	R:R:V127	4.85	No	No	0	8	8
105	R:R:F130	R:R:T165	5.19	No	No	0	6	7
106	R:R:F130	R:R:L217	4.87	No	No	0	6	7
107	R:R:N131	R:R:T165	5.85	No	No	0	8	7
108	R:R:L132	R:R:Y370	4.69	No	Yes	0	8	9
109	R:R:I135	R:R:R139	3.76	No	No	7	9	9
110	R:R:I135	R:R:Y370	6.04	No	Yes	7	9	9
111	R:R:M225	R:R:S136	6.13	No	Yes	0	8	9
112	R:R:S136	R:R:Y229	6.36	Yes	Yes	0	9	9
113	R:R:L137	R:R:V224	4.47	No	No	0	6	7
114	R:R:E138	R:R:Q153	10.19	No	Yes	4	9	7
115	R:R:R139	R:R:Y229	5.14	No	Yes	0	9	9
116	R:R:R139	R:R:Y370	4.12	No	Yes	7	9	9
117	R:R:G141	R:R:Y140	4.35	No	Yes	0	6	8
118	R:R:C144	R:R:Y140	10.75	No	Yes	0	7	8
119	R:R:L231	R:R:Y140	8.21	No	Yes	0	5	8
120	R:R:I232	R:R:Y140	3.63	No	Yes	0	9	8
121	R:R:I143	R:R:I232	5.89	No	No	0	9	9
122	R:R:C144	R:R:E235	6.08	No	No	0	7	6
123	R:R:L147	R:R:Q148	3.99	No	No	0	7	5
124	R:R:S149	R:R:W152	3.71	No	No	4	8	5
125	R:R:Q153	R:R:S149	4.33	Yes	No	4	7	8
126	R:R:Q153	R:R:W152	8.76	Yes	No	4	7	5
127	R:R:H157	R:R:W152	4.23	No	No	0	7	5
128	R:R:S156	R:R:T154	6.4	No	No	0	5	8
129	R:R:F170	R:R:W166	4.01	No	No	0	4	9
130	R:R:I172	R:R:M173	4.37	Yes	Yes	1	6	8
131	R:R:M173	R:R:Y176	8.38	Yes	Yes	1	8	7
132	R:R:L213	R:R:M173	4.24	No	Yes	1	7	8
133	R:R:P175	R:R:T174	5.25	No	No	0	8	4
134	R:R:P175	R:R:Y176	4.17	No	Yes	1	8	7
135	R:R:P175	R:R:W209	9.46	No	Yes	1	8	8
136	R:R:Y176	R:R:Y179	25.81	Yes	No	1	7	5
137	R:R:W209	R:R:Y176	3.86	Yes	Yes	1	8	7
138	R:R:F198	R:R:Y179	35.07	Yes	No	1	5	5
139	R:R:N181	R:R:V183	4.43	Yes	No	0	5	3
140	R:R:N181	R:R:N194	12.26	Yes	No	0	5	3
141	R:R:L182	R:R:R197	4.86	No	Yes	0	5	4
142	R:R:T192	R:R:V183	7.93	No	No	0	3	3
143	R:R:A193	R:R:P184	3.74	No	No	0	3	1
144	R:R:F185	R:R:T192	7.78	No	No	0	4	3
145	R:R:A193	R:R:T186	5.03	No	No	0	3	3
146	R:R:K187	R:R:Q191	4.07	No	No	0	2	2
147	R:R:N194	R:R:T192	4.39	No	No	0	3	3
148	R:R:M195	R:R:R197	4.96	No	Yes	0	4	4
149	R:R:L199	R:R:R197	3.64	No	Yes	0	4	4
150	R:R:F198	R:R:L200	8.53	Yes	Yes	0	5	4
151	R:R:F198	R:R:W209	8.02	Yes	Yes	1	5	8
152	R:R:F198	R:R:H210	4.53	Yes	Yes	1	5	6
153	R:R:D203	R:R:V204	4.38	No	No	0	2	2
154	R:R:D203	R:R:M205	5.54	No	No	0	2	4
155	R:R:Q207	R:R:V204	7.16	No	No	0	4	2
156	R:R:M205	R:R:S208	4.6	No	No	0	4	4
157	R:R:H210	R:R:Q206	8.65	Yes	No	0	6	5
158	R:R:Q207	R:R:Y338	38.33	No	No	0	4	5
159	R:R:H210	R:R:W209	4.23	Yes	Yes	1	6	8
160	R:R:F212	R:R:W209	5.01	No	Yes	1	5	8
161	R:R:L213	R:R:W209	13.67	No	Yes	1	7	8
162	R:R:H210	R:R:N333	3.83	Yes	No	0	6	7
163	R:R:A337	R:R:H210	4.39	No	Yes	0	6	6
164	R:R:T211	R:R:Y338	6.24	No	No	0	6	5
165	R:R:F212	R:R:L213	3.65	No	No	1	5	7
166	R:R:F212	R:R:I216	10.05	No	No	0	5	5
167	R:R:F218	R:R:L214	3.65	Yes	Yes	9	8	7
168	R:R:F330	R:R:L214	3.65	No	Yes	9	7	7
169	R:R:L215	R:R:L219	4.15	No	No	0	3	6
170	R:R:F218	R:R:F322	7.5	Yes	No	0	8	9
171	R:R:F218	R:R:F323	6.43	Yes	No	0	8	6
172	R:R:F218	R:R:M327	8.71	Yes	No	0	8	6
173	R:R:F218	R:R:F330	11.79	Yes	No	9	8	7
174	R:R:I223	R:R:L219	4.28	No	No	0	4	6
175	R:R:F322	R:R:G222	4.52	No	No	0	9	6
176	R:R:F323	R:R:G222	4.52	No	No	0	6	6
177	R:R:F322	R:R:M225	6.22	No	No	0	9	8
178	R:R:L315	R:R:Y229	11.72	Yes	Yes	0	8	9
179	R:R:I318	R:R:Y229	7.25	No	Yes	0	9	9
180	R:R:I232	R:R:L315	4.28	No	Yes	0	9	8
181	R:R:I312	R:R:S233	6.19	No	No	0	8	6
182	R:R:L315	R:R:S233	6.01	Yes	No	0	8	6
183	R:R:L234	R:R:Q238	9.32	No	No	0	4	5
184	R:R:K308	R:R:L236	4.23	No	No	0	8	9
185	R:R:I312	R:R:L236	4.28	No	No	0	8	9
186	R:R:K241	R:R:Y237	15.53	No	No	0	5	6
187	R:R:I240	R:R:L305	7.14	No	No	0	5	4
188	R:R:I240	R:R:K309	4.36	No	No	0	5	6
189	R:R:E243	R:R:N304	5.26	Yes	No	10	5	4
190	R:R:E243	R:R:K308	6.75	Yes	No	10	5	8
191	R:R:K308	R:R:N304	8.39	No	No	10	8	4
192	R:R:M314	R:R:V317	4.56	No	No	0	9	7
193	R:R:I369	R:R:M314	5.83	Yes	No	0	9	9
194	R:R:I318	R:R:Y370	10.88	No	Yes	0	9	9
195	R:R:F330	R:R:W326	5.01	No	Yes	0	7	8
196	R:R:S359	R:R:W326	8.65	No	Yes	0	7	8
197	R:R:S362	R:R:W326	8.65	No	Yes	0	9	8
198	R:R:I355	R:R:P328	5.08	No	No	0	6	9
199	R:R:I329	R:R:N333	5.66	No	No	0	7	7
200	R:R:I329	R:R:I355	4.42	No	No	0	7	6
201	R:R:I329	R:R:L356	5.71	No	No	0	7	6
202	R:R:S342	R:R:W335	8.65	No	Yes	0	4	5
203	R:R:A343	R:R:W335	12.96	No	Yes	0	4	5
204	R:R:R346	R:R:W335	5	No	Yes	0	4	5
205	R:R:L347	R:R:W335	6.83	No	Yes	0	5	5
206	R:R:E344	R:R:R336	10.47	No	No	0	1	4
207	R:R:D339	R:R:S342	7.36	No	No	0	4	4
208	R:R:E344	R:R:T340	5.64	No	No	0	1	2
209	R:R:R345	R:R:S342	6.59	No	No	0	5	4
210	R:R:R346	R:R:T350	6.47	No	No	0	4	3
211	R:R:I352	R:R:I355	4.42	No	No	0	5	6
212	R:R:I352	R:R:L356	4.28	No	No	1	5	6
213	R:R:F354	R:R:L358	12.18	No	No	0	4	8
214	R:R:L357	R:R:Y360	3.52	No	Yes	2	7	7
215	R:R:S363	R:R:Y360	3.82	Yes	Yes	0	9	7
216	R:R:I369	R:R:Y370	3.63	Yes	Yes	0	9	9
217	R:R:C371	R:R:F377	4.19	No	No	0	8	9
218	R:R:F372	R:R:F377	8.57	Yes	No	0	6	9
219	R:R:N374	R:R:R376	13.26	No	No	0	9	7
220	R:R:L379	R:R:R378	4.86	Yes	No	3	5	9
221	R:R:M382	R:R:R378	3.72	Yes	No	3	5	9
222	R:R:L379	R:R:M382	5.65	Yes	Yes	3	5	5
223	R:R:F381	R:R:F385	24.65	No	No	0	7	6
224	R:R:F385	R:R:T384	5.19	No	No	0	6	6
225	R:R:P221	R:R:T129	3.5	No	No	0	9	8
226	R:R:C91	R:R:S363	3.44	No	Yes	0	7	9
227	R:R:C325	R:R:S362	3.44	No	No	0	8	9
228	R:R:A228	R:R:S136	3.42	No	Yes	0	6	9
229	R:R:A84	R:R:V62	3.39	No	No	0	9	9
230	R:R:A383	R:R:V65	3.39	No	No	0	5	8
231	R:R:A158	R:R:V75	3.39	No	No	0	7	7
232	R:R:I100	R:R:P101	3.39	Yes	No	0	5	5
233	R:R:I220	R:R:P221	3.39	No	No	0	6	9
234	R:R:L147	R:R:P146	3.28	No	No	0	7	8
235	R:R:S363	R:R:S55	3.26	Yes	No	0	9	8
236	R:R:N202	R:R:P201	3.26	No	No	0	5	5
237	R:R:A84	R:R:I63	3.25	No	No	0	9	7
238	R:R:A193	R:R:M195	3.22	No	No	0	3	4
239	R:R:V133	R:R:V224	3.21	No	No	0	7	7
240	R:R:A244	R:R:L305	3.15	No	No	0	4	4
241	R:R:A332	R:R:L347	3.15	No	No	0	5	5
242	R:R:T74	R:R:T76	3.14	No	No	6	7	8
243	R:R:I63	R:R:V85	3.07	No	No	0	7	6
244	R:R:I369	R:R:V365	3.07	Yes	No	0	9	7
245	R:R:K115	R:R:S180	3.06	No	No	0	5	6
246	R:R:I51	R:R:T361	3.04	Yes	No	0	7	5
247	R:R:F372	R:R:G58	3.01	Yes	No	0	6	8
248	R:R:F109	R:R:G110	3.01	Yes	No	0	6	7
249	R:R:L137	R:R:S136	3	No	Yes	0	6	9
250	R:R:L231	R:R:V227	2.98	No	No	0	5	5
251	R:R:L236	R:R:V311	2.98	No	No	0	9	9
252	R:R:N304	R:R:S301	2.98	No	No	0	4	4
253	R:R:L315	R:R:V311	2.98	Yes	No	0	8	9
254	R:R:L321	R:R:V317	2.98	No	No	0	6	7
255	R:R:I216	R:R:I220	2.94	No	No	0	5	6
256	R:R:I223	R:R:M226	2.92	No	No	0	4	6
257	R:R:I368	R:R:M373	2.92	No	No	0	6	7
258	R:R:I369	R:R:M373	2.92	Yes	No	0	9	7
259	R:R:I240	R:R:K241	2.91	No	No	0	5	5
260	R:R:I100	R:R:L104	2.85	Yes	No	0	5	4
261	R:R:I172	R:R:L168	2.85	Yes	No	0	6	5
262	R:R:I178	R:R:L200	2.85	No	Yes	0	5	4
263	R:R:L200	R:R:M205	2.83	Yes	No	0	4	4
264	R:R:A383	R:R:R68	2.77	No	No	0	5	5
265	R:R:L214	R:R:L215	2.77	Yes	No	0	7	3
266	R:R:K145	R:R:Q148	2.71	No	No	0	6	5
267	R:R:E243	R:R:L305	2.65	Yes	No	0	5	4
268	R:R:N189	R:R:Q191	2.64	No	No	0	4	2
269	R:R:F323	R:R:V319	2.62	No	No	0	6	8
270	R:R:S353	R:R:Y48	2.54	No	Yes	0	5	7
271	R:R:F52	R:R:L92	2.44	Yes	No	0	5	5
272	R:R:G349	R:R:S348	1.86	No	No	0	3	5
273	R:R:P351	R:R:S353	1.78	No	No	0	4	5
274	R:R:G58	R:R:L57	1.71	No	No	0	8	4
275	R:R:A303	R:R:S301	1.71	No	No	0	4	4
276	R:R:A383	R:R:T384	1.68	No	No	0	5	6
277	R:R:L200	R:R:P201	1.64	Yes	No	0	4	5
278	R:R:G239	R:R:Q238	1.64	No	No	0	7	5
279	R:R:E243	R:R:G239	1.64	Yes	No	0	5	7
280	R:R:S128	R:R:S86	1.63	No	No	0	9	8
281	R:R:A302	R:R:M306	1.61	No	No	0	4	5
282	R:R:C364	R:R:L54	1.59	No	No	0	7	5
283	R:R:T60	R:R:V56	1.59	No	No	0	4	6
284	R:R:A334	R:R:L214	1.58	No	Yes	0	6	7
285	R:R:T60	R:R:T64	1.57	No	No	0	4	4
286	R:R:I316	R:R:V320	1.54	No	No	0	7	6
287	R:R:A341	R:R:D339	1.54	No	No	0	1	4
288	R:R:M327	R:R:S331	1.53	No	No	0	6	6
289	R:R:I172	R:R:T171	1.52	Yes	No	0	6	5
290	R:R:F242	R:R:G239	1.51	No	No	0	4	7
291	R:R:K187	R:R:T186	1.5	No	No	0	2	3
292	R:R:L46	R:R:V43	1.49	No	No	0	4	5
293	R:R:N181	R:R:S180	1.49	Yes	No	0	5	6
294	R:R:I100	R:R:I45	1.47	Yes	No	0	5	5
295	R:R:I312	R:R:I316	1.47	No	No	0	8	7
296	R:R:I78	R:R:K155	1.45	No	No	0	5	4
297	R:R:I45	R:R:L46	1.43	No	No	0	5	4
298	R:R:P177	R:R:Y119	1.39	No	No	0	6	6
299	R:R:P177	R:R:Y176	1.39	No	Yes	0	6	7
300	R:R:A307	R:R:R310	1.38	No	No	0	6	8
301	R:R:L321	R:R:L324	1.38	No	No	0	6	5
302	R:R:H157	R:R:T154	1.37	No	No	0	7	8
303	R:R:R376	R:R:T74	1.29	No	No	6	7	7
304	R:R:R376	R:R:T76	1.29	No	No	6	7	8
305	R:R:K70	R:R:R71	1.24	No	No	0	7	6
306	R:R:M306	R:R:R310	1.24	No	No	0	5	8
307	R:R:F52	R:R:L53	1.22	Yes	No	0	5	4
308	R:R:F185	R:R:N190	1.21	No	No	0	4	4
309	R:R:K145	R:R:Y140	1.19	No	Yes	0	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	11.931	10	1	0
2	R:R:Y48	6.57	7	2	7
3	R:R:I51	4.165	4	2	7
4	R:R:F52	4.624	5	2	5
5	R:R:N69	9.4175	4	3	6
6	R:R:F79	6.474	5	0	8
7	R:R:M95	7.5125	4	2	7
8	R:R:N98	5.9775	4	1	7
9	R:R:I100	3.434	5	2	5
10	R:R:F109	10.762	5	5	6
11	R:R:F120	7.48	4	8	5
12	R:R:S136	4.7275	4	0	9
13	R:R:Y140	5.626	5	0	8
14	R:R:Q153	7.2525	4	4	7
15	R:R:I172	3.345	4	1	6
16	R:R:M173	5.3975	4	1	8
17	R:R:Y176	8.3525	8	1	7
18	R:R:N181	7.565	4	0	5
19	R:R:R197	4.9725	4	0	4
20	R:R:F198	14.0375	4	1	5
21	R:R:L200	3.9625	4	0	4
22	R:R:W209	7.375	6	1	8
23	R:R:H210	5.126	5	1	6
24	R:R:L214	2.9125	4	9	7
25	R:R:F218	7.616	5	9	8
26	R:R:Y229	7.6175	4	0	9
27	R:R:E243	4.075	4	10	5
28	R:R:L315	6.2475	4	0	8
29	R:R:W326	7.4175	4	0	8
30	R:R:W335	8.36	4	0	5
31	R:R:Y360	4.936	5	2	7
32	R:R:S363	3.735	4	0	9
33	R:R:I369	3.8625	4	0	9
34	R:R:Y370	5.48	6	7	9
35	R:R:F372	4.79	4	0	6
36	R:R:L379	6.4325	4	3	5
37	R:R:M382	6.2275	4	3	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:N98	59.6569	8.72	Yes	Yes	1	0	7
2	R:R:L99	R:R:N98	62.5286	5.49	No	Yes	0	6	7
3	R:R:L99	R:R:Y48	62.3634	5.86	No	Yes	0	6	7
4	R:R:L357	R:R:Y48	20.5273	11.72	No	Yes	2	7	7
5	R:R:M95	R:R:Y48	25.0381	7.18	Yes	Yes	2	7	7
6	R:R:I100	R:R:Y48	23.8691	3.63	Yes	Yes	2	5	7
7	R:R:M95	R:R:Y360	41.8996	9.58	Yes	Yes	2	7	7
8	R:R:S363	R:R:Y360	63.9581	3.82	Yes	Yes	0	9	7
9	R:R:S363	R:R:S55	12.0394	3.26	Yes	No	0	9	8
10	R:R:L357	R:R:Y360	17.2427	3.52	No	Yes	2	7	7
11	R:R:D87	R:R:S363	58.7738	4.42	No	Yes	0	9	9
12	R:R:D87	R:R:N59	10.1588	12.12	No	No	0	9	9
13	L:L:?1	R:R:Y176	76.9314	8.68	Yes	Yes	1	0	7
14	R:R:P177	R:R:Y176	53.1131	1.39	No	Yes	0	6	7
15	R:R:P177	R:R:Y119	52.7509	1.39	No	No	0	6	6
16	R:R:F170	R:R:Y119	49.7776	6.19	No	No	0	4	6
17	R:R:F170	R:R:W166	49.1677	4.01	No	No	0	4	9
18	R:R:S82	R:R:W166	48.2783	6.18	No	No	0	9	9
19	R:R:I162	R:R:S82	53.7294	6.19	No	No	0	7	9
20	R:R:F79	R:R:I162	53.9072	7.54	Yes	No	0	8	7
21	R:R:F79	R:R:I135	59.5743	3.77	Yes	No	0	8	9
22	R:R:I135	R:R:Y370	45.9657	6.04	No	Yes	7	9	9
23	R:R:L80	R:R:Y370	100	3.52	No	Yes	0	8	9
24	R:R:C371	R:R:L80	97.6747	6.35	No	No	0	8	8
25	R:R:C371	R:R:V62	65.5464	8.54	No	No	0	8	9
26	R:R:F372	R:R:V62	11.9123	3.93	Yes	No	0	6	9
27	L:L:?1	R:R:S359	72.4523	4.77	Yes	No	0	0	7
28	R:R:S359	R:R:W326	72.1792	8.65	No	Yes	0	7	8
29	R:R:F330	R:R:W326	71.8234	5.01	No	Yes	0	7	8
30	R:R:F218	R:R:F330	64.4981	11.79	Yes	No	9	8	7
31	R:R:F218	R:R:F322	69.803	7.5	Yes	No	0	8	9
32	R:R:F322	R:R:M225	72.2173	6.22	No	No	0	9	8
33	R:R:M225	R:R:S136	72.5032	6.13	No	Yes	0	8	9
34	R:R:S136	R:R:Y229	76.2834	6.36	Yes	Yes	0	9	9
35	R:R:R139	R:R:Y229	59.5426	5.14	No	Yes	0	9	9
36	R:R:R139	R:R:Y370	46.1881	4.12	No	Yes	7	9	9
37	R:R:I318	R:R:Y229	46.5311	7.25	No	Yes	0	9	9
38	R:R:I318	R:R:Y370	46.7471	10.88	No	Yes	0	9	9
39	R:R:C371	R:R:F377	31.9187	4.19	No	No	0	8	9
40	R:R:F372	R:R:F377	11.4867	8.57	Yes	No	0	6	9
41	R:R:A84	R:R:V62	54.2503	3.39	No	No	0	9	9
42	R:R:A84	R:R:I63	51.6582	3.25	No	No	0	9	7
43	R:R:I63	R:R:L81	46.4358	4.28	No	No	0	7	6
44	R:R:F377	R:R:V65	20.1398	7.87	No	No	0	9	8
45	R:R:L66	R:R:L81	41.1626	4.15	No	No	0	7	6
46	R:R:L66	R:R:N77	38.507	4.12	No	No	0	7	9
47	R:R:M72	R:R:N77	25.0381	7.01	No	No	0	8	9
48	R:R:M72	R:R:N69	13.939	4.21	No	Yes	3	8	6
49	R:R:N77	R:R:T74	11.2516	10.24	No	No	0	9	7
50	R:R:E138	R:R:F79	21.7471	11.66	No	Yes	0	9	8
51	R:R:E138	R:R:Q153	10.9339	10.19	No	Yes	4	9	7
52	R:R:M173	R:R:Y176	12.4333	8.38	Yes	Yes	1	8	7
53	R:R:D87	R:R:N366	60.8831	12.12	No	No	0	9	9
54	R:R:L83	R:R:N366	60.5019	8.24	No	No	0	9	9
55	R:R:L132	R:R:L83	60.2668	4.15	No	No	0	8	9
56	R:R:F120	R:R:Y119	14.9873	11.35	Yes	No	0	5	6
57	R:R:I100	R:R:P101	40.305	3.39	Yes	No	0	5	5
58	R:R:F107	R:R:P101	38.291	8.67	No	No	0	8	5
59	L:L:?1	R:R:R197	32.9797	6.43	Yes	Yes	0	0	4
60	R:R:M195	R:R:R197	25.6607	4.96	No	Yes	0	4	4
61	R:R:A193	R:R:M195	23.1512	3.22	No	No	0	3	4
62	R:R:A193	R:R:T186	18.094	5.03	No	No	0	3	3
63	R:R:K187	R:R:T186	12.9797	1.5	No	No	0	2	3
64	R:R:F107	R:R:F109	32.1093	28.94	No	Yes	5	8	6
65	R:R:F109	R:R:N181	23.8945	12.08	Yes	Yes	0	6	5
66	R:R:Y176	R:R:Y179	21.7281	25.81	Yes	No	1	7	5
67	R:R:L315	R:R:Y229	82.5604	11.72	Yes	Yes	0	8	9
68	R:R:I232	R:R:L315	30.8259	4.28	No	Yes	0	9	8
69	R:R:I232	R:R:Y140	25.9149	3.63	No	Yes	0	9	8
70	R:R:K145	R:R:Y140	10.5146	1.19	No	Yes	0	6	8
71	R:R:W209	R:R:Y176	33.1703	3.86	Yes	Yes	1	8	7
72	R:R:F198	R:R:Y179	20.216	35.07	Yes	No	1	5	5
73	R:R:F198	R:R:W209	21.3659	8.02	Yes	Yes	1	5	8
74	L:L:?1	R:R:N333	20.2097	10.17	Yes	No	0	0	7
75	R:R:H210	R:R:N333	16.3151	3.83	Yes	No	0	6	7
76	R:R:F198	R:R:H210	13.1004	4.53	Yes	Yes	1	5	6
77	R:R:F198	R:R:L200	50.1017	8.53	Yes	Yes	0	5	4
78	R:R:L200	R:R:M205	32.0584	2.83	Yes	No	0	4	4
79	R:R:D203	R:R:M205	22.9606	5.54	No	No	0	2	4
80	R:R:D203	R:R:V204	18.3926	4.38	No	No	0	2	2
81	R:R:Q207	R:R:V204	13.8119	7.16	No	No	0	4	2
82	R:R:L315	R:R:S233	10.0762	6.01	Yes	No	0	8	6
83	R:R:L315	R:R:V311	42.554	2.98	Yes	No	0	8	9
84	R:R:L236	R:R:V311	40.2986	2.98	No	No	0	9	9
85	R:R:K308	R:R:L236	38.3736	4.23	No	No	0	8	9
86	R:R:E243	R:R:K308	28.2147	6.75	Yes	No	10	5	8
87	R:R:E243	R:R:G239	10.5146	1.64	Yes	No	0	5	7
88	R:R:E243	R:R:L305	15.6798	2.65	Yes	No	0	5	4
89	R:R:I240	R:R:L305	10.5146	7.14	No	No	0	5	4
90	R:R:I369	R:R:Y370	21.9822	3.63	Yes	Yes	0	9	9
91	R:R:I369	R:R:M314	11.0292	5.83	Yes	No	0	9	9
92	L:L:?1	R:R:L347	25.5273	10.25	Yes	No	0	0	5
93	R:R:L347	R:R:W335	20.629	6.83	No	Yes	0	5	5
94	R:R:S342	R:R:W335	10.413	8.65	No	Yes	0	4	5
95	R:R:A383	R:R:V65	14.4473	3.39	No	No	0	5	8
96	R:R:F372	R:R:G58	10.6099	3.01	Yes	No	0	6	8
97	R:R:L132	R:R:Y370	60.9657	4.69	No	Yes	0	8	9
98	R:R:I135	R:R:R139	13.8818	3.76	No	No	7	9	9
99	R:R:I100	R:R:M95	26.2579	5.83	Yes	Yes	2	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:N98	8.72	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:M121	4.49	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y176	8.68	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:R197	6.43	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:N333	10.17	1	Yes	No	0	7	0	1
L:L:?1	R:R:R336	36	1	Yes	No	0	4	0	1
L:L:?1	R:R:L347	10.25	1	Yes	No	0	5	0	1
L:L:?1	R:R:I352	16.62	1	Yes	No	0	5	0	1
L:L:?1	R:R:L356	13.18	1	Yes	No	0	6	0	1
L:L:?1	R:R:S359	4.77	1	Yes	No	0	7	0	1
R:R:C94	R:R:M121	4.86	0	No	No	7	7	2	1
R:R:L99	R:R:N98	5.49	0	No	Yes	6	7	2	1
R:R:N102	R:R:N98	4.09	0	No	Yes	6	7	2	1
R:R:M121	R:R:N98	5.61	1	No	Yes	7	7	1	1
R:R:T118	R:R:Y176	8.74	1	No	Yes	6	7	2	1
R:R:T118	R:R:Y179	24.97	1	No	No	6	5	2	2
R:R:G122	R:R:Y176	5.79	0	No	Yes	6	7	2	1
R:R:M173	R:R:Y176	8.38	1	Yes	Yes	8	7	2	1
R:R:P175	R:R:Y176	4.17	1	No	Yes	8	7	2	1
R:R:P175	R:R:W209	9.46	1	No	Yes	8	8	2	2
R:R:Y176	R:R:Y179	25.81	1	Yes	No	7	5	1	2
R:R:W209	R:R:Y176	3.86	1	Yes	Yes	8	7	2	1
R:R:L182	R:R:R197	4.86	0	No	Yes	5	4	2	1
R:R:M195	R:R:R197	4.96	0	No	Yes	4	4	2	1
R:R:L199	R:R:R197	3.64	0	No	Yes	4	4	2	1
R:R:H210	R:R:W209	4.23	1	Yes	Yes	6	8	2	2
R:R:H210	R:R:N333	3.83	1	Yes	No	6	7	2	1
R:R:S359	R:R:W326	8.65	0	No	Yes	7	8	1	2
R:R:I329	R:R:N333	5.66	0	No	No	7	7	2	1
R:R:I329	R:R:I355	4.42	0	No	No	7	6	2	2
R:R:I329	R:R:L356	5.71	0	No	No	7	6	2	1
R:R:L347	R:R:W335	6.83	0	No	Yes	5	5	1	2
R:R:E344	R:R:R336	10.47	0	No	No	1	4	2	1
R:R:I352	R:R:I355	4.42	1	No	No	5	6	1	2
R:R:I352	R:R:L356	4.28	1	No	No	5	6	1	1
R:R:A332	R:R:L347	3.15	0	No	No	5	5	2	1
R:R:P177	R:R:Y176	1.39	0	No	Yes	6	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XOV_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	274
Number of Links	309
Number of Hubs	37
Number of Links mediated by Hubs	147
Number of Communities	10
Number of Nodes involved in Communities	56
Number of Links involved in Communities	73

Path Summary
Number Of Nodes in MetaPath	100
Number Of Links MetaPath	99
Number of Shortest Paths	55466
Length Of Smallest Path	3
Average Path Length	13.9012
Length of Longest Path	32
Minimum Path Strength	1.31
Average Path Strength	6.53069
Maximum Path Strength	30.44
Minimum Path Correlation	0.7
Average Path Correlation	0.927932
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	47.4882
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.1385
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • molecular transducer activity • cholecystokinin receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • cholecystokinin signaling pathway • head development • forebrain development • brain development • nervous system development • central nervous system development • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of biological quality • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • neuron migration • cellular developmental process • generation of neurons • neurogenesis • cell differentiation • cell migration • cell motility • axonogenesis • cell projection organization • plasma membrane bounded cell projection morphogenesis • cell development • neuron projection development • cell morphogenesis • cellular component organization • cell projection morphogenesis • neuron differentiation • neuron projection morphogenesis • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • axon development • cell morphogenesis involved in neuron differentiation • anatomical structure morphogenesis • neuron development • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	IA1
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	IA1
Name	2-[2-[[4-(4-chloranyl-2,5-dimethoxy-phenyl)-5-(2-cyclohexylethyl)-1,3-thiazol-2-yl]carbamoyl]-5,7-dimethyl-indol-1-yl]ethanoic acid
Synonyms
Identifier
Formula	C32 H36 Cl N3 O5 S
Molecular Weight	610.163
SMILES
PubChem	9852833
Formal Charge	0
Total Atoms	78
Total Chiral Atoms	0
Total Bonds	82
Total Aromatic Bonds	21


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32238
Sequence	>7XOV_nogp_Chain_R A V Q I L L Y S L I F L L S V L G N T L V I T V L I R N K R M R T V T N I F L L S L A V S D L M L C L F C M P F N L I P N L L K D F I F G S A V C K T T T Y F M G T S V S V S T F N L V A I S L E R Y G A I C K P L Q S R V W Q T K S H A L K V I A A T W C L S F T I M T P Y P I Y S N L V P F T K N N N Q T A N M C R F L L P N D V M Q Q S W H T F L L L I L F L I P G I V M M V A Y G L I S L E L Y Q G I K F E A S A A N L M A K K R V I R M L I V I V V L F F L C W M P I F S A N A W R A Y D T A S A E R R L S G T P I S F I L L L S Y T S S C V N P I I Y C F M N K R F R L G F M A T F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XOU	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	Gs/β1/γ2	3.2	2022-07-20	doi.org/10.1038/s41421-022-00420-3
	7XOU (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		3.2	2022-07-20	doi.org/10.1038/s41421-022-00420-3
	7XOV	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	SR146131	-	Gs/β1/γ2	3	2022-07-20	doi.org/10.1038/s41421-022-00420-3
	7XOV (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	SR146131	-		3	2022-07-20	doi.org/10.1038/s41421-022-00420-3
	7EZH	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	Gi1/β1/γ2	3.2	2021-08-25	doi.org/10.1038/s41589-021-00841-3
	7EZH (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		3.2	2021-08-25	doi.org/10.1038/s41589-021-00841-3
	7EZK	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1-Gs)/β1/γ2	3.1	2021-08-25	doi.org/10.1038/s41589-021-00841-3
	7EZK (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		3.1	2021-08-25	doi.org/10.1038/s41589-021-00841-3
	7EZM	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGsL-Gq)/β1/γ2	2.9	2021-08-25	doi.org/10.1038/s41589-021-00841-3
	7EZM (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.9	2021-08-25	doi.org/10.1038/s41589-021-00841-3
	7F8U	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Lintitript	-	-	2.8	2021-10-13	doi.org/10.1038/s41589-021-00866-8
	7F8Y	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Devazepide	-	-	2.5	2021-10-13	doi.org/10.1038/s41589-021-00866-8
	7F8X	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	NN9056	-	-	3	2021-12-29	doi.org/10.1038/s41589-021-00866-8
	7MBX	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	Gs/β1/γ1	1.95	2021-05-26	doi.org/10.1371/journal.pbio.3001295
	7MBX (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		1.95	2021-05-26	doi.org/10.1371/journal.pbio.3001295
	7MBY	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.44	2021-05-26	doi.org/10.1371/journal.pbio.3001295
	7MBY (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.44	2021-05-26	doi.org/10.1371/journal.pbio.3001295
	9BKJ	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.59	2024-05-22	doi.org/10.1371/journal.pbio.3002673
	9BKJ (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.59	2024-05-22	doi.org/10.1371/journal.pbio.3002673
	9BKK	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.51	2024-05-22	doi.org/10.1371/journal.pbio.3002673
	9BKK (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.51	2024-05-22	doi.org/10.1371/journal.pbio.3002673

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