psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:D1	L:L:M3	4.16	No	No	0	0	0
2	L:L:?2	L:L:M3	6.08	Yes	No	0	0	0
3	L:L:?2	L:L:M6	6.08	Yes	No	0	0	0
4	L:L:?2	R:R:P101	3.53	Yes	No	1	0	5
5	L:L:?2	R:R:K105	14.16	Yes	No	1	0	4
6	L:L:?2	R:R:F107	3.49	Yes	Yes	1	0	8
7	L:L:?2	R:R:T186	6.34	Yes	Yes	1	0	3
8	L:L:M3	R:R:E344	8.12	No	No	0	0	1
9	L:L:G4	R:R:R197	4.5	No	Yes	0	0	4
10	L:L:W5	R:R:N333	3.39	Yes	No	0	0	7
11	L:L:W5	R:R:R336	8	Yes	No	0	0	4
12	L:L:W5	R:R:L347	3.42	Yes	Yes	0	0	5
13	L:L:W5	R:R:I352	16.44	Yes	No	0	0	5
14	L:L:M6	R:R:C196	4.86	No	Yes	0	0	9
15	L:L:D7	R:R:Y179	3.45	No	No	0	0	5
16	L:L:?9	L:L:F8	9.04	Yes	Yes	0	0	0
17	L:L:F8	R:R:V125	7.87	Yes	No	0	0	7
18	L:L:F8	R:R:I329	5.02	Yes	No	0	0	7
19	L:L:?9	R:R:C94	7.86	Yes	Yes	3	0	7
20	L:L:?9	R:R:L356	3.43	Yes	No	3	0	6
21	L:L:?9	R:R:Y360	8.7	Yes	Yes	3	0	7
22	R:R:Q44	R:R:Y48	5.64	No	Yes	0	4	7
23	R:R:L47	R:R:Y48	5.86	No	Yes	5	5	7
24	R:R:L357	R:R:L47	4.15	Yes	No	5	7	5
25	R:R:L99	R:R:Y48	8.21	No	Yes	0	6	7
26	R:R:L357	R:R:Y48	4.69	Yes	Yes	5	7	7
27	R:R:F52	R:R:L53	3.65	No	No	0	5	4
28	R:R:F52	R:R:V56	7.87	No	No	0	5	6
29	R:R:F52	R:R:M95	7.46	No	Yes	0	5	7
30	R:R:C91	R:R:S55	6.89	No	No	2	7	8
31	R:R:S363	R:R:S55	4.89	No	No	2	9	8
32	R:R:C364	R:R:S55	3.44	No	No	0	7	8
33	R:R:A84	R:R:N59	4.69	No	Yes	0	9	9
34	R:R:D87	R:R:N59	9.42	Yes	Yes	2	9	9
35	R:R:L88	R:R:N59	8.24	No	Yes	0	7	9
36	R:R:N59	R:R:P367	9.77	Yes	No	2	9	9
37	R:R:C371	R:R:V62	5.12	Yes	No	0	8	9
38	R:R:L66	R:R:N77	9.61	No	Yes	0	7	9
39	R:R:L66	R:R:R376	7.29	No	Yes	0	7	7
40	R:R:N69	R:R:R71	10.85	No	No	8	6	6
41	R:R:M72	R:R:N69	5.61	No	No	8	8	6
42	R:R:A383	R:R:N69	4.69	No	No	0	5	6
43	R:R:K70	R:R:R73	3.71	No	No	0	7	8
44	R:R:M72	R:R:R71	6.2	No	No	8	8	6
45	R:R:L379	R:R:R71	3.64	No	No	0	5	6
46	R:R:M72	R:R:N77	5.61	No	Yes	0	8	9
47	R:R:K155	R:R:R73	3.71	No	No	0	4	8
48	R:R:T74	R:R:T76	4.71	No	No	0	7	8
49	R:R:A158	R:R:V75	5.09	No	No	0	7	7
50	R:R:L80	R:R:N77	5.49	No	Yes	0	8	9
51	R:R:I162	R:R:I78	5.89	No	No	0	7	5
52	R:R:A134	R:R:F79	4.16	No	Yes	0	8	8
53	R:R:F79	R:R:I135	3.77	Yes	No	0	8	9
54	R:R:E138	R:R:F79	15.16	No	Yes	0	9	8
55	R:R:F79	R:R:V161	5.24	Yes	No	0	8	6
56	R:R:F79	R:R:I162	6.28	Yes	No	0	8	7
57	R:R:C371	R:R:L80	6.35	Yes	No	0	8	8
58	R:R:I162	R:R:S82	9.29	No	No	0	7	9
59	R:R:S128	R:R:S86	6.52	No	No	0	9	8
60	R:R:D87	R:R:S363	10.31	Yes	No	2	9	9
61	R:R:D87	R:R:N366	4.04	Yes	No	0	9	9
62	R:R:D87	R:R:P367	11.27	Yes	No	2	9	9
63	R:R:F93	R:R:M89	3.73	No	No	0	5	7
64	R:R:M89	R:R:S124	7.67	No	No	0	7	6
65	R:R:C94	R:R:L90	4.76	Yes	No	0	7	8
66	R:R:L90	R:R:S124	6.01	No	No	0	8	6
67	R:R:C91	R:R:S363	5.16	No	No	2	7	9
68	R:R:F93	R:R:L92	4.87	No	No	0	5	5
69	R:R:F120	R:R:F93	8.57	No	No	0	5	5
70	R:R:C94	R:R:M121	4.86	Yes	No	0	7	7
71	R:R:C94	R:R:Y360	8.06	Yes	Yes	3	7	7
72	R:R:M95	R:R:P96	5.03	Yes	No	0	7	8
73	R:R:M95	R:R:Y360	4.79	Yes	Yes	0	7	7
74	R:R:L99	R:R:P96	3.28	No	No	0	6	8
75	R:R:I100	R:R:P96	3.39	No	No	0	5	8
76	R:R:N102	R:R:N98	4.09	No	No	0	6	7
77	R:R:L356	R:R:N98	5.49	No	No	3	6	7
78	R:R:N98	R:R:Y360	3.49	No	Yes	3	7	7
79	R:R:I100	R:R:P101	3.39	No	No	0	5	5
80	R:R:F107	R:R:P101	14.45	Yes	No	1	8	5
81	R:R:I352	R:R:N102	4.25	No	No	0	5	6
82	R:R:K105	R:R:T186	4.5	No	Yes	1	4	3
83	R:R:K105	R:R:K187	7.18	No	Yes	1	4	2
84	R:R:D106	R:R:K187	8.3	No	Yes	0	4	2
85	R:R:D106	R:R:N190	6.73	No	No	0	4	4
86	R:R:F107	R:R:F109	9.65	Yes	No	0	8	6
87	R:R:C196	R:R:F107	4.19	Yes	Yes	0	9	8
88	R:R:F109	R:R:V113	9.18	No	No	0	6	5
89	R:R:F109	R:R:T117	3.89	No	No	0	6	6
90	R:R:G110	R:R:V113	3.68	No	No	0	7	5
91	R:R:C114	R:R:C196	5.46	No	Yes	0	9	9
92	R:R:F120	R:R:T116	6.49	No	No	0	5	4
93	R:R:T118	R:R:Y179	8.74	No	No	0	6	5
94	R:R:F120	R:R:Y119	4.13	No	No	0	5	6
95	R:R:F170	R:R:Y119	9.28	No	No	0	4	6
96	R:R:Y119	R:R:Y176	11.91	No	No	0	6	7
97	R:R:F170	R:R:T123	15.56	No	No	0	4	6
98	R:R:V125	R:R:W326	8.58	No	Yes	0	7	8
99	R:R:S126	R:R:S169	6.52	Yes	No	0	7	8
100	R:R:M173	R:R:S126	4.6	No	Yes	0	8	7
101	R:R:L217	R:R:S126	4.5	No	Yes	0	7	7
102	R:R:V127	R:R:W166	9.81	No	No	0	8	9
103	R:R:S169	R:R:V127	4.85	No	No	0	8	8
104	R:R:P221	R:R:T129	3.5	Yes	No	0	9	8
105	R:R:L132	R:R:Y370	4.69	No	Yes	0	8	9
106	R:R:P221	R:R:V133	3.53	Yes	No	0	9	7
107	R:R:I135	R:R:R139	6.26	No	Yes	9	9	9
108	R:R:I135	R:R:Y370	3.63	No	Yes	9	9	9
109	R:R:M225	R:R:S136	6.13	No	No	0	8	9
110	R:R:A228	R:R:S136	3.42	No	No	0	6	9
111	R:R:S136	R:R:Y229	6.36	No	Yes	0	9	9
112	R:R:R139	R:R:Y229	11.32	Yes	Yes	0	9	9
113	R:R:M314	R:R:R139	3.72	No	Yes	0	9	9
114	R:R:R139	R:R:Y370	5.14	Yes	Yes	9	9	9
115	R:R:G141	R:R:Y140	4.35	No	No	0	6	8
116	R:R:C144	R:R:Y140	9.41	No	No	0	7	8
117	R:R:L231	R:R:Y140	8.21	No	No	0	5	8
118	R:R:Q153	R:R:S149	5.78	No	No	0	7	8
119	R:R:Q153	R:R:R150	3.5	No	No	0	7	6
120	R:R:V151	R:R:W152	4.9	No	Yes	0	5	5
121	R:R:Q153	R:R:W152	5.48	No	Yes	0	7	5
122	R:R:H157	R:R:W152	4.23	No	Yes	0	7	5
123	R:R:H157	R:R:V161	6.92	No	No	0	7	6
124	R:R:P175	R:R:T174	5.25	No	No	0	8	4
125	R:R:I178	R:R:P175	3.39	Yes	No	0	5	8
126	R:R:P175	R:R:W209	6.76	No	Yes	0	8	8
127	R:R:P177	R:R:Y176	9.74	No	No	0	6	7
128	R:R:F198	R:R:I178	5.02	Yes	Yes	4	5	5
129	R:R:I178	R:R:L200	4.28	Yes	Yes	4	5	4
130	R:R:F198	R:R:Y179	8.25	Yes	No	0	5	5
131	R:R:N181	R:R:N194	8.17	No	No	0	5	3
132	R:R:C196	R:R:N181	4.72	Yes	No	0	9	5
133	R:R:L182	R:R:P184	3.28	No	No	0	5	1
134	R:R:L182	R:R:R197	6.07	No	Yes	0	5	4
135	R:R:P184	R:R:V183	3.53	No	No	0	1	3
136	R:R:K187	R:R:T186	6.01	Yes	Yes	1	2	3
137	R:R:A193	R:R:T186	5.03	No	Yes	0	3	3
138	R:R:M195	R:R:T186	4.52	No	Yes	0	4	3
139	R:R:K187	R:R:N189	8.39	Yes	No	0	2	4
140	R:R:M195	R:R:R197	4.96	No	Yes	0	4	4
141	R:R:R197	R:R:R336	5.33	Yes	No	0	4	4
142	R:R:E344	R:R:R197	3.49	No	Yes	0	1	4
143	R:R:F198	R:R:L200	12.18	Yes	Yes	4	5	4
144	R:R:F198	R:R:W209	9.02	Yes	Yes	4	5	8
145	R:R:F198	R:R:H210	5.66	Yes	Yes	4	5	6
146	R:R:L200	R:R:P201	3.28	Yes	No	0	4	5
147	R:R:L200	R:R:M205	15.55	Yes	No	0	4	4
148	R:R:L200	R:R:Q206	3.99	Yes	No	0	4	5
149	R:R:M205	R:R:N202	11.22	No	No	0	4	5
150	R:R:D203	R:R:V204	5.84	No	No	0	2	2
151	R:R:H210	R:R:Q206	3.71	Yes	No	0	6	5
152	R:R:Q207	R:R:Y338	3.38	No	No	0	4	5
153	R:R:H210	R:R:W209	4.23	Yes	Yes	4	6	8
154	R:R:L213	R:R:W209	4.56	No	Yes	0	7	8
155	R:R:A337	R:R:H210	4.39	No	Yes	0	6	6
156	R:R:T211	R:R:Y338	3.75	No	No	0	6	5
157	R:R:F212	R:R:I216	6.28	No	No	0	5	5
158	R:R:L213	R:R:L217	5.54	No	No	0	7	7
159	R:R:F330	R:R:L213	3.65	No	No	0	7	7
160	R:R:L214	R:R:L219	5.54	No	No	0	7	6
161	R:R:I216	R:R:L215	4.28	No	No	0	5	3
162	R:R:L215	R:R:L219	5.54	No	No	0	3	6
163	R:R:F218	R:R:F322	5.36	Yes	Yes	10	8	9
164	R:R:F218	R:R:W326	4.01	Yes	Yes	10	8	8
165	R:R:F218	R:R:M327	7.46	Yes	No	0	8	6
166	R:R:F218	R:R:F330	5.36	Yes	No	0	8	7
167	R:R:I220	R:R:P221	3.39	No	Yes	0	6	9
168	R:R:F322	R:R:M225	8.71	Yes	No	0	9	8
169	R:R:F323	R:R:M226	8.71	No	No	0	6	6
170	R:R:L315	R:R:Y229	21.1	No	Yes	0	8	9
171	R:R:V319	R:R:Y229	3.79	No	Yes	0	8	9
172	R:R:L315	R:R:S233	4.5	No	No	0	8	6
173	R:R:L234	R:R:Q238	6.65	No	No	0	4	5
174	R:R:I312	R:R:L236	4.28	No	No	0	8	9
175	R:R:K241	R:R:Y237	19.11	No	No	0	5	6
176	R:R:F242	R:R:G239	4.52	No	No	0	4	7
177	R:R:I240	R:R:L305	5.71	Yes	No	0	5	4
178	R:R:I240	R:R:K308	8.72	Yes	No	0	5	8
179	R:R:E243	R:R:L305	6.63	No	No	0	5	4
180	R:R:N304	R:R:S301	5.96	No	No	0	4	4
181	R:R:K308	R:R:N304	9.79	No	No	0	8	4
182	R:R:K309	R:R:M306	7.2	No	No	0	6	5
183	R:R:M306	R:R:R310	6.2	No	No	0	5	8
184	R:R:K309	R:R:R313	7.43	No	No	0	6	7
185	R:R:R310	R:R:R313	4.26	No	No	0	8	7
186	R:R:I318	R:R:M314	4.37	No	No	0	9	9
187	R:R:I318	R:R:Y370	12.09	No	Yes	0	9	9
188	R:R:F322	R:R:F323	5.36	Yes	No	0	9	6
189	R:R:F322	R:R:W326	9.02	Yes	Yes	10	9	8
190	R:R:C325	R:R:S362	5.16	No	No	0	8	9
191	R:R:S359	R:R:W326	3.71	No	Yes	0	7	8
192	R:R:S362	R:R:W326	3.71	No	Yes	0	9	8
193	R:R:M327	R:R:P328	3.35	No	No	0	6	9
194	R:R:L358	R:R:P328	3.28	No	No	0	8	9
195	R:R:F330	R:R:I329	3.77	No	No	0	7	7
196	R:R:A343	R:R:W335	7.78	No	No	0	4	5
197	R:R:R346	R:R:W335	7	No	No	6	4	5
198	R:R:L347	R:R:W335	5.69	Yes	No	6	5	5
199	R:R:E344	R:R:T340	5.64	No	No	0	1	2
200	R:R:R345	R:R:S342	7.91	No	No	0	5	4
201	R:R:L347	R:R:R346	4.86	Yes	No	6	5	4
202	R:R:L347	R:R:P351	3.28	Yes	No	0	5	4
203	R:R:G349	R:R:S348	3.71	No	No	0	3	5
204	R:R:P351	R:R:T350	5.25	No	No	0	4	3
205	R:R:L356	R:R:Y360	8.21	No	Yes	3	6	7
206	R:R:N366	R:R:S362	4.47	No	No	0	9	9
207	R:R:F372	R:R:I368	8.79	No	No	0	6	6
208	R:R:C371	R:R:R376	5.57	Yes	Yes	0	8	7
209	R:R:F372	R:R:M373	3.73	No	No	0	6	7
210	R:R:N374	R:R:R376	6.03	No	Yes	0	9	7
211	R:R:F377	R:R:R378	9.62	No	No	11	9	9
212	R:R:F377	R:R:F381	5.36	No	No	11	9	7
213	R:R:F381	R:R:R378	7.48	No	No	11	7	9
214	R:R:F385	R:R:T384	3.89	No	No	0	6	6
215	R:R:S86	R:R:V127	3.23	No	No	0	8	8
216	R:R:S156	R:R:T154	3.2	No	No	0	5	8
217	R:R:A341	R:R:D339	3.09	No	No	0	1	4
218	R:R:M327	R:R:S331	3.07	No	No	0	6	6
219	R:R:I369	R:R:V365	3.07	No	No	0	9	7
220	R:R:I51	R:R:T361	3.04	No	No	0	7	5
221	R:R:K155	R:R:V75	3.04	No	No	0	4	7
222	R:R:C144	R:R:E235	3.04	No	No	0	7	6
223	L:L:F8	R:R:G122	3.01	Yes	No	0	0	6
224	R:R:F212	R:R:W209	3.01	No	Yes	0	5	8
225	R:R:F322	R:R:G222	3.01	Yes	No	0	9	6
226	R:R:N131	R:R:S82	2.98	No	No	0	8	9
227	R:R:L321	R:R:V317	2.98	No	No	0	6	7
228	R:R:L321	R:R:V365	2.98	No	No	0	6	7
229	R:R:N366	R:R:V365	2.96	No	No	0	9	7
230	R:R:L88	R:R:T60	2.95	No	No	0	7	4
231	R:R:I143	R:R:I232	2.94	No	No	0	9	9
232	R:R:I352	R:R:I355	2.94	No	No	0	5	6
233	R:R:I240	R:R:K241	2.91	Yes	No	0	5	5
234	R:R:I51	R:R:L47	2.85	No	No	5	7	5
235	R:R:I51	R:R:L357	2.85	No	Yes	5	7	7
236	R:R:I63	R:R:L81	2.85	No	No	0	7	6
237	R:R:I67	R:R:L81	2.85	No	No	0	3	6
238	R:R:E138	R:R:V75	2.85	No	No	0	9	7
239	R:R:I78	R:R:L159	2.85	No	No	0	5	5
240	R:R:I143	R:R:L236	2.85	No	No	0	9	9
241	R:R:I232	R:R:L315	2.85	No	No	0	9	8
242	R:R:K375	R:R:L379	2.82	No	No	0	6	5
243	R:R:G141	R:R:W152	2.81	No	Yes	0	6	5
244	R:R:L132	R:R:L83	2.77	No	No	0	8	9
245	R:R:L324	R:R:L358	2.77	No	No	0	5	8
246	R:R:L147	R:R:Q148	2.66	No	No	0	7	5
247	R:R:F130	R:R:S126	2.64	No	Yes	0	6	7
248	R:R:R376	R:R:V65	2.62	Yes	No	0	7	8
249	L:L:W5	R:R:A332	2.59	Yes	No	0	0	5
250	R:R:F130	R:R:T165	2.59	No	No	0	6	7
251	R:R:F381	R:R:T384	2.59	No	No	0	7	6
252	R:R:S353	R:R:Y48	2.54	No	Yes	0	5	7
253	R:R:F130	R:R:I172	2.51	No	No	0	6	6
254	R:R:F212	R:R:I172	2.51	No	No	0	5	6
255	R:R:I45	R:R:Y48	2.42	No	Yes	0	5	7
256	R:R:F242	R:R:Q238	2.34	No	No	0	4	5
257	L:L:?2	R:R:S348	2.15	Yes	No	0	0	5
258	R:R:F377	R:R:R376	2.14	No	Yes	0	9	7
259	R:R:G222	R:R:P221	2.03	No	Yes	0	6	9
260	R:R:C371	R:R:P367	1.88	Yes	No	0	8	9
261	R:R:G230	R:R:S233	1.86	No	No	0	1	6
262	R:R:G380	R:R:V65	1.84	No	No	0	8	8
263	R:R:G141	R:R:K145	1.74	No	No	0	6	6
264	R:R:G239	R:R:K308	1.74	No	No	0	7	8
265	R:R:G58	R:R:L57	1.71	No	No	0	8	4
266	R:R:A112	R:R:S111	1.71	No	No	0	3	4
267	R:R:K145	R:R:P146	1.67	No	No	0	6	8
268	R:R:A142	R:R:I143	1.62	No	No	0	8	9
269	R:R:A244	R:R:K241	1.61	No	No	0	4	5
270	R:R:V133	R:R:V224	1.6	No	No	0	7	7
271	R:R:T64	R:R:V65	1.59	No	No	0	4	8
272	R:R:A228	R:R:L137	1.58	No	No	0	6	6
273	R:R:A334	R:R:L214	1.58	No	No	0	6	7
274	R:R:I63	R:R:V85	1.54	No	No	0	7	6
275	R:R:I223	R:R:V227	1.54	No	No	0	4	5
276	R:R:I172	R:R:T171	1.52	No	No	0	6	5
277	R:R:L199	R:R:S180	1.5	No	No	0	4	6
278	R:R:L236	R:R:V311	1.49	No	No	0	9	9
279	R:R:N202	R:R:V204	1.48	No	No	0	5	2
280	R:R:L57	R:R:T60	1.47	No	No	0	4	4
281	R:R:L168	R:R:T171	1.47	No	No	0	5	5
282	R:R:I240	R:R:I312	1.47	Yes	No	0	5	8
283	R:R:N77	R:R:T74	1.46	Yes	No	0	9	7
284	R:R:I223	R:R:M226	1.46	No	No	0	4	6
285	R:R:I369	R:R:M373	1.46	No	No	0	9	7
286	R:R:I45	R:R:L103	1.43	No	No	0	5	5
287	R:R:I178	R:R:L199	1.43	Yes	No	0	5	4
288	R:R:L50	R:R:L53	1.38	No	No	7	4	4
289	R:R:L50	R:R:L54	1.38	No	No	7	4	5
290	R:R:L53	R:R:L54	1.38	No	No	7	4	5
291	R:R:L57	R:R:L61	1.38	No	No	0	4	7
292	R:R:L66	R:R:L81	1.38	No	No	0	7	6
293	R:R:H157	R:R:T154	1.37	No	No	0	7	8
294	R:R:K145	R:R:Q148	1.36	No	No	0	6	5
295	R:R:N188	R:R:N189	1.36	No	No	0	1	4
296	R:R:A337	R:R:Y338	1.33	No	No	0	6	5
297	R:R:F97	R:R:M95	1.24	No	Yes	0	6	7
298	R:R:F354	R:R:L357	1.22	No	Yes	0	4	7
299	L:L:D1	R:R:F185	1.19	No	No	0	0	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?2	5.97571	7	1	0
2	L:L:W5	6.768	5	0	0
3	L:L:F8	6.235	4	0	0
4	L:L:?9	7.2575	4	3	0
5	R:R:Y48	4.89333	6	5	7
6	R:R:N59	8.03	4	2	9
7	R:R:N77	5.5425	4	0	9
8	R:R:F79	6.922	5	0	8
9	R:R:D87	8.76	4	2	9
10	R:R:C94	6.385	4	3	7
11	R:R:M95	4.63	4	0	7
12	R:R:F107	7.945	4	1	8
13	R:R:S126	4.565	4	0	7
14	R:R:R139	6.61	4	9	9
15	R:R:W152	4.355	4	0	5
16	R:R:I178	3.53	4	4	5
17	R:R:T186	5.28	5	1	3
18	R:R:K187	7.47	4	1	2
19	R:R:C196	4.8075	4	0	9
20	R:R:R197	4.87	5	0	4
21	R:R:F198	8.026	5	4	5
22	R:R:L200	7.856	5	4	4
23	R:R:W209	5.516	5	4	8
24	R:R:H210	4.4975	4	4	6
25	R:R:F218	5.5475	4	10	8
26	R:R:P221	3.1125	4	0	9
27	R:R:Y229	10.6425	4	0	9
28	R:R:I240	4.7025	4	0	5
29	R:R:F322	6.292	5	10	9
30	R:R:W326	5.806	5	10	8
31	R:R:L347	4.3125	4	6	5
32	R:R:L357	3.2275	4	5	7
33	R:R:Y360	6.65	5	3	7
34	R:R:Y370	6.3875	4	9	9
35	R:R:C371	4.73	4	0	8
36	R:R:R376	4.73	5	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	R:R:P101	25.6133	3.53	Yes	No	1	0	5
2	L:L:?2	R:R:T186	11.2484	6.34	Yes	Yes	1	0	3
3	R:R:R197	R:R:R336	17.9811	5.33	Yes	No	0	4	4
4	L:L:W5	R:R:R336	19.4167	8	Yes	No	0	0	4
5	L:L:W5	R:R:L347	13.1474	3.42	Yes	Yes	0	0	5
6	L:L:W5	R:R:I352	34.1359	16.44	Yes	No	0	0	5
7	R:R:I100	R:R:P101	35.8668	3.39	No	No	0	5	5
8	R:R:I100	R:R:P96	36.6845	3.39	No	No	0	5	8
9	R:R:M95	R:R:P96	48.3282	5.03	Yes	No	0	7	8
10	R:R:M95	R:R:Y360	53.7343	4.79	Yes	Yes	0	7	7
11	L:L:?9	R:R:Y360	67.6449	8.7	Yes	Yes	3	0	7
12	L:L:?9	L:L:F8	100	9.04	Yes	Yes	0	0	0
13	L:L:F8	R:R:I329	28.698	5.02	Yes	No	0	0	7
14	R:R:F330	R:R:I329	28.748	3.77	No	No	0	7	7
15	R:R:F330	R:R:L213	52.326	3.65	No	No	0	7	7
16	R:R:L213	R:R:W209	40.5233	4.56	No	Yes	0	7	8
17	R:R:F198	R:R:W209	16.3002	9.02	Yes	Yes	4	5	8
18	L:L:F8	R:R:V125	72.8693	7.87	Yes	No	0	0	7
19	R:R:L99	R:R:P96	16.2502	3.28	No	No	0	6	8
20	R:R:L99	R:R:Y48	15.0373	8.21	No	Yes	0	6	7
21	R:R:V125	R:R:W326	72.9466	8.58	No	Yes	0	7	8
22	R:R:S362	R:R:W326	56.9462	3.71	No	Yes	0	9	8
23	R:R:N366	R:R:S362	55.0836	4.47	No	No	0	9	9
24	R:R:D87	R:R:N366	47.2697	4.04	Yes	No	0	9	9
25	R:R:D87	R:R:P367	33.5681	11.27	Yes	No	2	9	9
26	R:R:C371	R:R:P367	33.3318	1.88	Yes	No	0	8	9
27	R:R:C371	R:R:R376	18.7216	5.57	Yes	Yes	0	8	7
28	R:R:C371	R:R:L80	12.416	6.35	Yes	No	0	8	8
29	R:R:L80	R:R:N77	11.1712	5.49	No	Yes	0	8	9
30	R:R:F322	R:R:W326	59.7083	9.02	Yes	Yes	10	9	8
31	R:R:F322	R:R:M225	70.5706	8.71	Yes	No	0	9	8
32	R:R:M225	R:R:S136	69.8028	6.13	No	No	0	8	9
33	R:R:S136	R:R:Y229	67.445	6.36	No	Yes	0	9	9
34	R:R:R139	R:R:Y229	45.9613	11.32	Yes	Yes	0	9	9
35	R:R:I135	R:R:R139	38.1428	6.26	No	Yes	9	9	9
36	R:R:F79	R:R:I135	37.6158	3.77	Yes	No	0	8	9
37	R:R:F79	R:R:V161	22.7149	5.24	Yes	No	0	8	6
38	R:R:L213	R:R:L217	12.6976	5.54	No	No	0	7	7
39	R:R:L217	R:R:S126	11.4347	4.5	No	Yes	0	7	7
40	R:R:C94	R:R:L90	14.9873	4.76	Yes	No	0	7	8
41	R:R:L90	R:R:S124	13.7879	6.01	No	No	0	8	6
42	R:R:M89	R:R:S124	12.5795	7.67	No	No	0	7	6
43	R:R:F93	R:R:M89	11.362	3.73	No	No	0	5	7
44	R:R:I352	R:R:N102	37.3342	4.25	No	No	0	5	6
45	R:R:N98	R:R:Y360	21.9971	3.49	No	Yes	3	7	7
46	R:R:N102	R:R:N98	39.1786	4.09	No	No	0	6	7
47	R:R:H157	R:R:V161	21.6518	6.92	No	No	0	7	6
48	R:R:H157	R:R:W152	17.9675	4.23	No	Yes	0	7	5
49	R:R:G141	R:R:W152	11.8027	2.81	No	Yes	0	6	5
50	R:R:F212	R:R:W209	11.7209	3.01	No	Yes	0	5	8
51	R:R:F218	R:R:W326	15.8959	4.01	Yes	Yes	10	8	8
52	R:R:F218	R:R:F330	32.2052	5.36	Yes	No	0	8	7
53	R:R:L315	R:R:Y229	27.4986	21.1	No	Yes	0	8	9
54	R:R:I232	R:R:L315	23.9233	2.85	No	No	0	9	8
55	R:R:I143	R:R:I232	22.7194	2.94	No	No	0	9	9
56	R:R:I143	R:R:L236	20.3798	2.85	No	No	0	9	9
57	R:R:I312	R:R:L236	18.0402	4.28	No	No	0	8	9
58	R:R:I240	R:R:I312	16.7954	1.47	Yes	No	0	5	8
59	L:L:?9	R:R:L356	19.7892	3.43	Yes	No	3	0	6
60	R:R:L356	R:R:N98	18.9442	5.49	No	No	3	6	7
61	L:L:?9	R:R:C94	12.3342	7.86	Yes	Yes	3	0	7
62	R:R:F218	R:R:F322	18.5944	5.36	Yes	Yes	10	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?2	R:R:P101	3.53	1	Yes	No	0	5	0	1
L:L:?2	R:R:K105	14.16	1	Yes	No	0	4	0	1
L:L:?2	R:R:F107	3.49	1	Yes	Yes	0	8	0	1
L:L:?2	R:R:T186	6.34	1	Yes	Yes	0	3	0	1
L:L:M3	R:R:E344	8.12	0	No	No	0	1	0	1
L:L:G4	R:R:R197	4.5	0	No	Yes	0	4	0	1
L:L:W5	R:R:N333	3.39	0	Yes	No	0	7	0	1
L:L:W5	R:R:R336	8	0	Yes	No	0	4	0	1
L:L:W5	R:R:L347	3.42	0	Yes	Yes	0	5	0	1
L:L:W5	R:R:I352	16.44	0	Yes	No	0	5	0	1
L:L:M6	R:R:C196	4.86	0	No	Yes	0	9	0	1
L:L:D7	R:R:Y179	3.45	0	No	No	0	5	0	1
L:L:F8	R:R:V125	7.87	0	Yes	No	0	7	0	1
L:L:F8	R:R:I329	5.02	0	Yes	No	0	7	0	1
L:L:?9	R:R:C94	7.86	3	Yes	Yes	0	7	0	1
L:L:?9	R:R:L356	3.43	3	Yes	No	0	6	0	1
L:L:?9	R:R:Y360	8.7	3	Yes	Yes	0	7	0	1
R:R:C94	R:R:L90	4.76	3	Yes	No	7	8	1	2
R:R:C94	R:R:M121	4.86	3	Yes	No	7	7	1	2
R:R:C94	R:R:Y360	8.06	3	Yes	Yes	7	7	1	1
R:R:M95	R:R:Y360	4.79	0	Yes	Yes	7	7	2	1
R:R:N102	R:R:N98	4.09	0	No	No	6	7	2	2
R:R:L356	R:R:N98	5.49	3	No	No	6	7	1	2
R:R:N98	R:R:Y360	3.49	3	No	Yes	7	7	2	1
R:R:I100	R:R:P101	3.39	0	No	No	5	5	2	1
R:R:F107	R:R:P101	14.45	1	Yes	No	8	5	1	1
R:R:I352	R:R:N102	4.25	0	No	No	5	6	1	2
R:R:K105	R:R:T186	4.5	1	No	Yes	4	3	1	1
R:R:K105	R:R:K187	7.18	1	No	Yes	4	2	1	2
R:R:F107	R:R:F109	9.65	1	Yes	No	8	6	1	2
R:R:C196	R:R:F107	4.19	0	Yes	Yes	9	8	1	1
R:R:C114	R:R:C196	5.46	0	No	Yes	9	9	2	1
R:R:T118	R:R:Y179	8.74	0	No	No	6	5	2	1
R:R:V125	R:R:W326	8.58	0	No	Yes	7	8	1	2
R:R:F198	R:R:Y179	8.25	4	Yes	No	5	5	2	1
R:R:C196	R:R:N181	4.72	0	Yes	No	9	5	1	2
R:R:L182	R:R:R197	6.07	0	No	Yes	5	4	2	1
R:R:K187	R:R:T186	6.01	1	Yes	Yes	2	3	2	1
R:R:A193	R:R:T186	5.03	0	No	Yes	3	3	2	1
R:R:M195	R:R:T186	4.52	0	No	Yes	4	3	2	1
R:R:M195	R:R:R197	4.96	0	No	Yes	4	4	2	1
R:R:R197	R:R:R336	5.33	0	Yes	No	4	4	1	1
R:R:E344	R:R:R197	3.49	0	No	Yes	1	4	1	1
R:R:F330	R:R:I329	3.77	0	No	No	7	7	2	1
R:R:R346	R:R:W335	7	6	No	No	4	5	2	2
R:R:L347	R:R:W335	5.69	6	Yes	No	5	5	1	2
R:R:E344	R:R:T340	5.64	0	No	No	1	2	1	2
R:R:L347	R:R:R346	4.86	6	Yes	No	5	4	1	2
R:R:L347	R:R:P351	3.28	6	Yes	No	5	4	1	2
R:R:G349	R:R:S348	3.71	0	No	No	3	5	2	1
R:R:L356	R:R:Y360	8.21	3	No	Yes	6	7	1	1
L:L:F8	R:R:G122	3.01	0	Yes	No	0	6	0	1
R:R:I352	R:R:I355	2.94	0	No	No	5	6	1	2
L:L:W5	R:R:A332	2.59	0	Yes	No	0	5	0	1
L:L:?2	R:R:S348	2.15	1	Yes	No	0	5	0	1
L:L:D1	R:R:F185	1.19	0	No	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XOU_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.28
Number of Linked Nodes	276
Number of Links	299
Number of Hubs	36
Number of Links mediated by Hubs	136
Number of Communities	11
Number of Nodes involved in Communities	44
Number of Links involved in Communities	51

Path Summary
Number Of Nodes in MetaPath	63
Number Of Links MetaPath	62
Number of Shortest Paths	43490
Length Of Smallest Path	3
Average Path Length	14.455
Length of Longest Path	29
Minimum Path Strength	1.425
Average Path Strength	5.94757
Maximum Path Strength	16.21
Minimum Path Correlation	0.7
Average Path Correlation	0.926896
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	47.4336
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.2499
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • binding • molecular function activator activity • signaling receptor binding • signaling receptor activity • signaling receptor activator activity • hormone activity • protein binding • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • neuropeptide activity • neuropeptide hormone activity • peptide hormone receptor binding • hormone receptor binding • developmental process • multicellular organismal process • neuron migration • cellular developmental process • nervous system development • generation of neurons • neurogenesis • multicellular organism development • cell differentiation • anatomical structure development • cellular process • cell migration • cell motility • system development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • neuron migration • cellular developmental process • nervous system development • generation of neurons • neurogenesis • multicellular organism development • cell differentiation • anatomical structure development • cellular process • cell migration • cell motility • system development • behavior • eating behavior • feeding behavior • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • axonogenesis • cell projection organization • plasma membrane bounded cell projection morphogenesis • cell development • neuron projection development • cell morphogenesis • cellular component organization • cell projection morphogenesis • neuron differentiation • neuron projection morphogenesis • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • axon development • cell morphogenesis involved in neuron differentiation • anatomical structure morphogenesis • neuron development • digestion • cellular anatomical structure • extracellular region • axon • cell projection • neuron projection • plasma membrane bounded cell projection • extracellular space • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to hormone stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • organelle • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • molecular transducer activity • cholecystokinin receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • cholecystokinin signaling pathway • head development • forebrain development • brain development • central nervous system development • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	TYS
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	TYS
Name	O-SULFO-L-TYROSINE
Synonyms
Identifier
Formula	C9 H11 N O6 S
Molecular Weight	261.252
SMILES
PubChem	514186
Formal Charge	0
Total Atoms	28
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	6


Code	NH2
PDB Residues	L:L:?9
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32238
Sequence	>7XOU_nogp_Chain_R V Q I L L Y S L I F L L S V L G N T L V I T V L I R N K R M R T V T N I F L L S L A V S D L M L C L F C M P F N L I P N L L K D F I F G S A V C K T T T Y F M G T S V S V S T F N L V A I S L E R Y G A I C K P L Q S R V W Q T K S H A L K V I A A T W C L S F T I M T P Y P I Y S N L V P F T K N N N Q T A N M C R F L L P N D V M Q Q S W H T F L L L I L F L I P G I V M M V A Y G L I S L E L Y Q G I K F E A S A A N L M A K K R V I R M L I V I V V L F F L C W M P I F S A N A W R A Y D T A S A E R R L S G T P I S F I L L L S Y T S S C V N P I I Y C F M N K R F R L G F M A T F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9BKK	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.51	2024-05-22	To be published
	9BKK (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.51	2024-05-22	To be published
	9BKJ	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.59	2024-05-22	To be published
	9BKJ (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.59	2024-05-22	To be published
	7XOV	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	SR146131	-	Gs/β1/γ2	3	2022-07-20	10.1038/s41421-022-00420-3
	7XOV (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	SR146131	-		3	2022-07-20	10.1038/s41421-022-00420-3
	7XOU	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	Gs/β1/γ2	3.2	2022-07-20	10.1038/s41421-022-00420-3
	7XOU (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		3.2	2022-07-20	10.1038/s41421-022-00420-3
	7F8X	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	NN9056	-	-	3	2021-12-29	10.1038/s41589-021-00866-8
	7F8Y	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Devazepide	-	-	2.5	2021-10-13	10.1038/s41589-021-00866-8
	7F8U	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Lintitript	-	-	2.8	2021-10-13	10.1038/s41589-021-00866-8
	7EZK	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1-Gs)/β1/γ2	3.1	2021-08-25	10.1038/s41589-021-00841-3
	7EZK (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		3.1	2021-08-25	10.1038/s41589-021-00841-3
	7EZM	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGsL-Gq)/β1/γ2	2.9	2021-08-25	10.1038/s41589-021-00841-3
	7EZM (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.9	2021-08-25	10.1038/s41589-021-00841-3
	7EZH	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	Gi1/β1/γ2	3.2	2021-08-25	10.1038/s41589-021-00841-3
	7EZH (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		3.2	2021-08-25	10.1038/s41589-021-00841-3
	7MBY	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.44	2021-05-26	10.1371/journal.pbio.3001295
	7MBY (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.44	2021-05-26	10.1371/journal.pbio.3001295
	7MBX	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	Gs/β1/γ1	1.95	2021-05-26	10.1371/journal.pbio.3001295
	7MBX (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		1.95	2021-05-26	10.1371/journal.pbio.3001295

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