psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E38	R:R:Q40	3.82	No	No	0	3	1
2	R:R:E38	R:R:P41	4.72	No	No	0	3	4
3	R:R:Q40	R:R:W39	28.48	No	No	0	1	1
4	R:R:V43	R:R:W39	3.68	No	No	0	5	1
5	R:R:Q40	R:R:T350	4.25	No	Yes	0	1	3
6	R:R:P41	R:R:Q44	4.74	No	No	0	4	4
7	R:R:Q44	R:R:T350	5.67	No	Yes	0	4	3
8	R:R:Q44	R:R:S353	12.99	No	No	0	4	5
9	R:R:I45	R:R:L103	7.14	No	No	0	5	5
10	R:R:L99	R:R:Y48	9.38	No	Yes	0	6	7
11	R:R:S353	R:R:Y48	5.09	No	Yes	0	5	7
12	R:R:L357	R:R:Y48	17.58	No	Yes	0	7	7
13	R:R:Y360	R:R:Y48	3.97	Yes	Yes	0	7	7
14	R:R:L50	R:R:L54	4.15	No	No	0	4	5
15	R:R:I51	R:R:L357	5.71	No	No	0	7	7
16	R:R:F52	R:R:V56	10.49	Yes	No	0	5	6
17	R:R:C91	R:R:F52	5.59	No	Yes	6	7	5
18	R:R:F52	R:R:M95	6.22	Yes	No	6	5	7
19	R:R:N59	R:R:S55	4.47	Yes	No	0	9	8
20	R:R:C91	R:R:S55	6.89	No	No	0	7	8
21	R:R:L57	R:R:L61	6.92	No	No	0	4	7
22	R:R:D87	R:R:N59	6.73	Yes	Yes	2	9	9
23	R:R:L88	R:R:N59	5.49	No	Yes	0	7	9
24	R:R:N59	R:R:P367	8.15	Yes	No	2	9	9
25	R:R:F381	R:R:L61	6.09	No	No	0	7	7
26	R:R:C371	R:R:V62	8.54	No	Yes	3	8	9
27	R:R:F372	R:R:V62	3.93	Yes	Yes	3	6	9
28	R:R:F377	R:R:V62	9.18	Yes	Yes	3	9	9
29	R:R:F377	R:R:V65	9.18	Yes	No	3	9	8
30	R:R:F381	R:R:V65	3.93	No	No	3	7	8
31	R:R:T384	R:R:V65	7.93	No	No	3	6	8
32	R:R:L66	R:R:N77	4.12	No	No	0	7	9
33	R:R:L66	R:R:L81	5.54	No	No	0	7	6
34	R:R:F377	R:R:L66	3.65	Yes	No	0	9	7
35	R:R:N69	R:R:R71	12.05	Yes	No	0	6	6
36	R:R:N69	R:R:T384	5.85	Yes	No	0	6	6
37	R:R:K70	R:R:R73	12.38	No	No	0	7	8
38	R:R:L81	R:R:R73	3.64	No	No	0	6	8
39	R:R:T74	R:R:T76	4.71	No	No	0	7	8
40	R:R:N77	R:R:T74	7.31	No	No	0	9	7
41	R:R:A158	R:R:V75	5.09	No	No	0	7	7
42	R:R:A134	R:R:F79	4.16	No	Yes	0	8	8
43	R:R:F79	R:R:I135	3.77	Yes	No	0	8	9
44	R:R:E138	R:R:F79	7	Yes	Yes	0	9	8
45	R:R:A158	R:R:F79	4.16	No	Yes	0	7	8
46	R:R:F79	R:R:I162	5.02	Yes	No	0	8	7
47	R:R:C371	R:R:L80	6.35	No	No	0	8	8
48	R:R:N131	R:R:S82	7.45	No	No	0	8	9
49	R:R:I162	R:R:S82	6.19	No	No	0	7	9
50	R:R:S82	R:R:W166	3.71	No	No	0	9	9
51	R:R:D87	R:R:L83	8.14	Yes	No	2	9	9
52	R:R:L132	R:R:L83	4.15	No	No	2	8	9
53	R:R:L83	R:R:N366	8.24	No	Yes	2	9	9
54	R:R:S128	R:R:S86	4.89	No	No	0	9	8
55	R:R:D87	R:R:L90	4.07	Yes	No	0	9	8
56	R:R:D87	R:R:S128	4.42	Yes	No	0	9	9
57	R:R:D87	R:R:S363	4.42	Yes	No	0	9	9
58	R:R:D87	R:R:N366	5.39	Yes	Yes	2	9	9
59	R:R:D87	R:R:P367	4.83	Yes	No	2	9	9
60	R:R:F93	R:R:M89	4.98	No	No	8	5	7
61	R:R:F120	R:R:M89	3.73	No	No	8	5	7
62	R:R:M89	R:R:S124	4.6	No	No	0	7	6
63	R:R:L90	R:R:S124	9.01	No	No	0	8	6
64	R:R:C91	R:R:M95	6.48	No	No	6	7	7
65	R:R:F120	R:R:F93	23.58	No	No	8	5	5
66	R:R:C94	R:R:M121	6.48	No	No	0	7	7
67	R:R:C94	R:R:Y360	12.1	No	Yes	0	7	7
68	R:R:F109	R:R:F97	6.43	Yes	No	0	6	6
69	R:R:F97	R:R:T117	11.67	No	No	0	6	6
70	R:R:M121	R:R:N98	4.21	No	No	0	7	7
71	R:R:L356	R:R:N98	5.49	No	No	5	6	7
72	R:R:N98	R:R:Y360	10.47	No	Yes	5	7	7
73	R:R:L103	R:R:L99	9.69	No	No	0	5	6
74	R:R:D106	R:R:L104	9.5	No	No	0	4	4
75	R:R:K105	R:R:K187	7.18	No	No	0	4	2
76	R:R:D106	R:R:I108	5.6	No	No	0	4	4
77	R:R:F107	R:R:F109	9.65	Yes	Yes	4	8	6
78	R:R:F107	R:R:V113	5.24	Yes	No	4	8	5
79	R:R:C114	R:R:F107	5.59	No	Yes	4	9	8
80	R:R:C196	R:R:F107	8.38	No	Yes	4	9	8
81	R:R:F109	R:R:I108	12.56	Yes	No	0	6	4
82	R:R:F109	R:R:V113	5.24	Yes	No	4	6	5
83	R:R:K115	R:R:S111	4.59	No	No	0	5	4
84	R:R:L182	R:R:S111	4.5	No	No	0	5	4
85	R:R:C114	R:R:C196	7.28	No	No	4	9	9
86	R:R:T118	R:R:Y176	3.75	No	Yes	0	6	7
87	R:R:T123	R:R:Y119	7.49	No	No	10	6	6
88	R:R:F170	R:R:Y119	8.25	No	No	10	4	6
89	R:R:P177	R:R:Y119	9.74	No	No	0	6	6
90	L:L:M6	R:R:M121	4.33	No	No	0	0	7
91	R:R:F170	R:R:T123	6.49	No	No	10	4	6
92	R:R:M173	R:R:T123	4.52	Yes	No	0	8	6
93	R:R:V125	R:R:W326	4.9	No	Yes	0	7	8
94	L:L:F8	R:R:V125	3.93	Yes	No	0	0	7
95	R:R:F130	R:R:S126	5.28	Yes	No	11	6	7
96	R:R:L217	R:R:S126	4.5	No	No	11	7	7
97	R:R:N131	R:R:V127	4.43	No	No	0	8	8
98	R:R:V127	R:R:W166	18.39	No	No	0	8	9
99	R:R:F130	R:R:L217	3.65	Yes	No	11	6	7
100	R:R:L132	R:R:N366	6.87	No	Yes	2	8	9
101	R:R:I135	R:R:R139	5.01	No	No	0	9	9
102	R:R:M225	R:R:S136	7.67	No	Yes	0	8	9
103	R:R:S136	R:R:Y229	3.82	Yes	Yes	0	9	9
104	R:R:L137	R:R:V224	4.47	No	No	0	6	7
105	R:R:E138	R:R:W152	8.72	Yes	No	7	9	5
106	R:R:E138	R:R:Q153	11.47	Yes	No	0	9	7
107	R:R:E138	R:R:H157	3.69	Yes	Yes	7	9	7
108	R:R:R139	R:R:Y229	8.23	No	Yes	0	9	9
109	R:R:R139	R:R:Y370	6.17	No	Yes	0	9	9
110	R:R:C144	R:R:Y140	10.75	No	No	0	7	8
111	R:R:K145	R:R:Y140	13.14	Yes	No	0	6	8
112	R:R:L231	R:R:Y140	8.21	No	No	0	5	8
113	R:R:A142	R:R:Q153	4.55	No	No	0	8	7
114	R:R:C144	R:R:E235	6.08	No	No	0	7	6
115	R:R:K145	R:R:Q148	4.07	Yes	No	0	6	5
116	R:R:Q153	R:R:S149	8.66	No	No	0	7	8
117	R:R:H157	R:R:W152	8.46	Yes	No	7	7	5
118	R:R:S156	R:R:T154	4.8	No	No	0	5	8
119	R:R:H157	R:R:V161	6.92	Yes	No	0	7	6
120	R:R:F170	R:R:W166	8.02	No	No	0	4	9
121	R:R:I172	R:R:M173	4.37	No	Yes	0	6	8
122	R:R:M173	R:R:Y176	4.79	Yes	Yes	0	8	7
123	R:R:P175	R:R:T174	5.25	No	No	0	8	4
124	R:R:P175	R:R:W209	9.46	No	No	0	8	8
125	R:R:F198	R:R:Y176	7.22	Yes	Yes	9	5	7
126	L:L:D7	R:R:Y176	11.49	No	Yes	9	0	7
127	L:L:F8	R:R:Y176	5.16	Yes	Yes	0	0	7
128	R:R:I178	R:R:Y179	14.51	No	No	0	5	5
129	R:R:L200	R:R:Y179	8.21	Yes	No	0	4	5
130	R:R:F198	R:R:S180	3.96	Yes	No	0	5	6
131	R:R:L182	R:R:N194	6.87	No	No	0	5	3
132	R:R:N194	R:R:P184	6.52	No	No	0	3	1
133	R:R:A193	R:R:F185	4.16	No	No	0	3	4
134	R:R:F185	R:R:M195	8.71	No	Yes	1	4	4
135	L:L:?2	R:R:F185	6.99	Yes	No	1	0	4
136	R:R:M195	R:R:R197	16.13	Yes	No	1	4	4
137	L:L:?2	R:R:M195	5.07	Yes	Yes	1	0	4
138	L:L:M6	R:R:C196	6.48	No	No	0	0	9
139	L:L:?2	R:R:R197	15.68	Yes	No	1	0	4
140	L:L:G4	R:R:R197	6	No	No	1	0	4
141	R:R:F198	R:R:L200	6.09	Yes	Yes	0	5	4
142	L:L:D7	R:R:F198	13.14	No	Yes	9	0	5
143	R:R:L200	R:R:P201	4.93	Yes	No	0	4	5
144	R:R:L200	R:R:M205	7.07	Yes	No	0	4	4
145	R:R:N202	R:R:V204	5.91	No	No	0	5	2
146	R:R:M205	R:R:N202	4.21	No	No	0	4	5
147	R:R:D203	R:R:Q207	6.53	No	No	0	2	4
148	R:R:H210	R:R:Q206	7.42	No	No	0	6	5
149	R:R:Q206	R:R:R336	4.67	No	No	0	5	4
150	R:R:Q207	R:R:Y338	5.64	No	No	0	4	5
151	R:R:F212	R:R:W209	5.01	No	No	0	5	8
152	R:R:L213	R:R:W209	15.94	No	No	0	7	8
153	R:R:A337	R:R:H210	4.39	No	No	0	6	6
154	L:L:D7	R:R:H210	3.78	No	No	0	0	6
155	R:R:F212	R:R:I216	10.05	No	No	0	5	5
156	R:R:F330	R:R:L214	3.65	No	No	0	7	7
157	R:R:I216	R:R:L217	4.28	No	No	0	5	7
158	R:R:F218	R:R:L219	3.65	No	No	0	8	6
159	R:R:F218	R:R:F323	5.36	No	No	0	8	6
160	R:R:F218	R:R:M327	12.44	No	No	0	8	6
161	R:R:F322	R:R:M225	8.71	No	No	0	9	8
162	R:R:F323	R:R:M226	3.73	No	No	0	6	6
163	R:R:L315	R:R:Y229	15.24	No	Yes	0	8	9
164	R:R:V319	R:R:Y229	5.05	No	Yes	0	8	9
165	R:R:G230	R:R:S233	3.71	No	No	0	1	6
166	R:R:K241	R:R:Y237	16.72	No	No	0	5	6
167	R:R:I240	R:R:L305	5.71	No	No	0	5	4
168	R:R:E243	R:R:S300	12.94	No	No	0	5	5
169	R:R:N299	R:R:S298	4.47	No	No	0	5	4
170	R:R:K308	R:R:N304	8.39	No	No	0	8	4
171	R:R:M306	R:R:R310	7.44	No	No	0	5	8
172	R:R:I369	R:R:M314	4.37	Yes	No	0	9	9
173	R:R:M314	R:R:M373	4.33	No	No	0	9	7
174	R:R:L321	R:R:V317	4.47	No	No	0	6	7
175	R:R:I318	R:R:I369	7.36	No	Yes	2	9	9
176	R:R:I318	R:R:Y370	8.46	No	Yes	2	9	9
177	R:R:L321	R:R:V365	4.47	No	No	0	6	7
178	R:R:F322	R:R:W326	7.02	No	Yes	0	9	8
179	R:R:C325	R:R:W326	3.92	No	Yes	2	8	8
180	R:R:C325	R:R:S362	6.89	No	No	2	8	9
181	R:R:F330	R:R:W326	7.02	No	Yes	0	7	8
182	R:R:S362	R:R:W326	8.65	No	Yes	2	9	8
183	R:R:I329	R:R:I355	4.42	No	Yes	0	7	6
184	R:R:I329	R:R:L356	4.28	No	No	0	7	6
185	L:L:F8	R:R:F330	5.36	Yes	No	0	0	7
186	L:L:F8	R:R:N333	3.62	Yes	No	0	0	7
187	R:R:D339	R:R:W335	8.93	No	Yes	0	4	5
188	R:R:A343	R:R:W335	11.67	No	Yes	0	4	5
189	R:R:L347	R:R:W335	4.56	No	Yes	0	5	5
190	R:R:E344	R:R:R336	12.79	Yes	No	1	1	4
191	L:L:W5	R:R:R336	9	Yes	No	1	0	4
192	R:R:E344	R:R:T340	5.64	Yes	No	0	1	2
193	L:L:G4	R:R:E344	6.55	No	Yes	1	0	1
194	L:L:W5	R:R:E344	5.45	Yes	Yes	1	0	1
195	L:L:W5	R:R:L347	5.69	Yes	No	0	0	5
196	L:L:M3	R:R:S348	4.6	Yes	No	0	0	5
197	R:R:F354	R:R:T350	5.19	No	Yes	0	4	3
198	R:R:I352	R:R:I355	4.42	No	Yes	1	5	6
199	L:L:W5	R:R:I352	29.36	Yes	No	1	0	5
200	R:R:L356	R:R:Y360	10.55	No	Yes	5	6	7
201	R:R:S359	R:R:Y360	10.17	No	Yes	0	7	7
202	R:R:N366	R:R:S362	5.96	Yes	No	2	9	9
203	R:R:N366	R:R:Y370	5.81	Yes	Yes	2	9	9
204	R:R:F372	R:R:I368	3.77	Yes	No	0	6	6
205	R:R:I369	R:R:Y370	3.63	Yes	Yes	2	9	9
206	R:R:C371	R:R:F377	11.17	No	Yes	3	8	9
207	R:R:F372	R:R:F377	5.36	Yes	Yes	3	6	9
208	R:R:F381	R:R:T384	5.19	No	No	3	7	6
209	L:L:?2	L:L:D1	8.76	Yes	No	1	0	0
210	L:L:D1	L:L:M3	9.7	No	Yes	1	0	0
211	L:L:?2	L:L:M3	6.08	Yes	Yes	1	0	0
212	L:L:G4	L:L:W5	4.22	No	Yes	1	0	0
213	L:L:?2	R:R:P101	3.53	Yes	No	0	0	5
214	R:R:P221	R:R:V133	3.53	Yes	No	0	9	7
215	R:R:P184	R:R:V183	3.53	No	No	0	1	3
216	R:R:L80	R:R:Y370	3.52	No	Yes	0	8	9
217	R:R:P221	R:R:T129	3.5	Yes	No	0	9	8
218	R:R:P351	R:R:T350	3.5	No	Yes	0	4	3
219	R:R:G122	R:R:M173	3.49	No	Yes	0	6	8
220	R:R:D339	R:R:Y338	3.45	No	No	0	4	5
221	R:R:A228	R:R:S136	3.42	No	Yes	0	6	9
222	R:R:A84	R:R:V62	3.39	No	Yes	0	9	9
223	R:R:I100	R:R:P101	3.39	No	No	0	5	5
224	R:R:I220	R:R:P221	3.39	No	Yes	0	6	9
225	R:R:S126	R:R:S169	3.26	No	No	0	7	8
226	R:R:S169	R:R:V127	3.23	No	No	0	8	8
227	R:R:V133	R:R:V224	3.21	No	No	0	7	7
228	R:R:T186	R:R:T192	3.14	No	No	0	3	3
229	R:R:I312	R:R:S233	3.1	No	No	0	8	6
230	R:R:I63	R:R:V85	3.07	No	No	0	7	6
231	R:R:I369	R:R:V317	3.07	Yes	No	0	9	7
232	R:R:I369	R:R:V365	3.07	Yes	No	0	9	7
233	R:R:K155	R:R:V75	3.04	No	No	0	4	7
234	R:R:M195	R:R:V183	3.04	Yes	No	0	4	3
235	R:R:F372	R:R:G58	3.01	Yes	No	0	6	8
236	R:R:F107	R:R:G110	3.01	Yes	No	0	8	7
237	R:R:L47	R:R:V43	2.98	No	No	0	5	5
238	R:R:L81	R:R:V85	2.98	No	No	0	6	6
239	R:R:L236	R:R:V311	2.98	No	No	0	9	9
240	R:R:L315	R:R:V311	2.98	No	No	0	8	9
241	R:R:L321	R:R:V320	2.98	No	No	0	6	6
242	R:R:L61	R:R:T64	2.95	No	No	0	7	4
243	L:L:?2	R:R:N102	2.95	Yes	No	0	0	6
244	R:R:I63	R:R:I67	2.94	No	No	0	7	3
245	R:R:I223	R:R:M226	2.92	No	No	0	4	6
246	R:R:I78	R:R:K155	2.91	No	No	0	5	4
247	R:R:I240	R:R:K308	2.91	No	No	0	5	8
248	R:R:F52	R:R:P96	2.89	Yes	No	0	5	8
249	R:R:F97	R:R:P96	2.89	No	No	0	6	8
250	R:R:I232	R:R:L236	2.85	No	No	0	9	9
251	R:R:I232	R:R:L315	2.85	No	No	0	9	8
252	R:R:I312	R:R:L236	2.85	No	No	0	8	9
253	R:R:Q191	R:R:T192	2.83	No	No	0	2	3
254	R:R:K309	R:R:L305	2.82	No	No	0	6	4
255	R:R:K375	R:R:L379	2.82	No	No	0	6	5
256	R:R:M72	R:R:N69	2.8	No	Yes	0	8	6
257	R:R:M72	R:R:N77	2.8	No	No	0	8	9
258	R:R:L88	R:R:L92	2.77	No	No	0	7	5
259	R:R:L215	R:R:L219	2.77	No	No	0	3	6
260	R:R:E38	R:R:K105	2.7	No	No	0	3	4
261	R:R:F323	R:R:V319	2.62	No	No	0	6	8
262	R:R:F120	R:R:T116	2.59	No	No	0	5	4
263	R:R:F130	R:R:T165	2.59	Yes	No	0	6	7
264	R:R:T211	R:R:Y338	2.5	No	No	0	6	5
265	R:R:M306	R:R:R313	2.48	No	No	0	5	7
266	R:R:K375	R:R:R378	2.48	No	No	0	6	9
267	R:R:F130	R:R:L168	2.44	Yes	No	0	6	5
268	R:R:N69	R:R:R68	2.41	Yes	No	0	6	5
269	R:R:G222	R:R:P221	2.03	No	Yes	0	6	9
270	R:R:G349	R:R:P351	2.03	No	No	0	3	4
271	R:R:R346	R:R:W335	2	No	Yes	0	4	5
272	R:R:A383	R:R:G380	1.95	No	No	0	5	8
273	R:R:G141	R:R:S149	1.86	No	No	0	6	8
274	R:R:G141	R:R:K145	1.74	No	Yes	0	6	6
275	R:R:G380	R:R:L379	1.71	No	No	0	8	5
276	R:R:C325	R:R:T361	1.69	No	No	0	8	5
277	R:R:I355	R:R:P328	1.69	Yes	No	0	6	9
278	R:R:K145	R:R:P146	1.67	Yes	No	0	6	8
279	R:R:S136	R:R:V133	1.62	Yes	No	0	9	7
280	R:R:A142	R:R:I143	1.62	No	No	0	8	9
281	R:R:A332	R:R:I352	1.62	No	No	1	5	5
282	R:R:A332	R:R:I355	1.62	No	Yes	1	5	6
283	R:R:C364	R:R:L54	1.59	No	No	0	7	5
284	R:R:A334	R:R:L214	1.58	No	No	0	6	7
285	R:R:T60	R:R:T64	1.57	No	No	0	4	4
286	R:R:I223	R:R:V227	1.54	No	No	0	4	5
287	R:R:I316	R:R:V320	1.54	No	No	0	7	6
288	R:R:M205	R:R:S208	1.53	No	No	0	4	4
289	R:R:F242	R:R:G239	1.51	No	No	0	4	7
290	R:R:L53	R:R:V56	1.49	No	No	0	4	6
291	R:R:N304	R:R:S301	1.49	No	No	0	4	4
292	R:R:N181	R:R:V183	1.48	No	No	0	5	3
293	R:R:D339	R:R:S342	1.47	No	No	0	4	4
294	R:R:N194	R:R:T192	1.46	No	No	0	3	3
295	R:R:I240	R:R:K241	1.45	No	No	0	5	5
296	R:R:L379	R:R:M382	1.41	No	No	0	5	5
297	R:R:L46	R:R:L47	1.38	No	No	0	4	5
298	R:R:A383	R:R:R71	1.38	No	No	0	5	6
299	R:R:L231	R:R:L234	1.38	No	No	0	5	4
300	R:R:L80	R:R:N374	1.37	No	No	0	8	9
301	R:R:H157	R:R:T154	1.37	Yes	No	0	7	8
302	R:R:L147	R:R:Q148	1.33	No	No	0	7	5
303	R:R:F242	R:R:S298	1.32	No	No	0	4	4
304	L:L:M3	R:R:R345	1.24	Yes	No	0	0	5
305	R:R:E243	R:R:F242	1.17	No	No	0	5	4
306	R:R:F385	R:R:R68	1.07	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y48	9.005	4	0	7
2	R:R:F52	6.2975	4	6	5
3	R:R:N59	6.21	4	2	9
4	R:R:V62	6.26	4	3	9
5	R:R:N69	5.7775	4	0	6
6	R:R:F79	4.822	5	0	8
7	R:R:D87	5.42857	7	2	9
8	R:R:F107	6.374	5	4	8
9	R:R:F109	8.47	4	4	6
10	R:R:F130	3.49	4	11	6
11	R:R:S136	4.1325	4	0	9
12	R:R:E138	7.72	4	7	9
13	R:R:K145	5.155	4	0	6
14	R:R:H157	5.11	4	7	7
15	R:R:M173	4.2925	4	0	8
16	R:R:Y176	6.482	5	9	7
17	R:R:M195	8.2375	4	1	4
18	R:R:F198	7.6025	4	9	5
19	R:R:L200	6.575	4	0	4
20	R:R:P221	3.1125	4	0	9
21	R:R:Y229	8.085	4	0	9
22	R:R:W326	6.302	5	2	8
23	R:R:W335	6.79	4	0	5
24	R:R:E344	7.6075	4	1	1
25	R:R:T350	4.6525	4	0	3
26	R:R:I355	3.0375	4	1	6
27	R:R:Y360	9.452	5	5	7
28	R:R:N366	6.454	5	2	9
29	R:R:I369	4.3	5	2	9
30	R:R:Y370	5.518	5	2	9
31	R:R:F372	4.0175	4	3	6
32	R:R:F377	7.708	5	3	9
33	L:L:?2	7.00857	7	1	0
34	L:L:M3	5.405	4	1	0
35	L:L:W5	10.744	5	1	0
36	L:L:F8	4.5175	4	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q44	R:R:S353	24.0886	12.99	No	No	0	4	5
2	R:R:S353	R:R:Y48	25.7619	5.09	No	Yes	0	5	7
3	R:R:Y360	R:R:Y48	35.6317	3.97	Yes	Yes	0	7	7
4	R:R:C94	R:R:Y360	11.1309	12.1	No	Yes	0	7	7
5	R:R:C94	R:R:M121	11.1672	6.48	No	No	0	7	7
6	L:L:M6	R:R:M121	27.1158	4.33	No	No	0	0	7
7	L:L:M6	R:R:C196	27.1845	6.48	No	No	0	0	9
8	R:R:C196	R:R:F107	26.9663	8.38	No	Yes	4	9	8
9	R:R:F107	R:R:F109	27.9686	9.65	Yes	Yes	4	8	6
10	R:R:F109	R:R:F97	30.8019	6.43	Yes	No	0	6	6
11	R:R:F97	R:R:P96	31.7557	2.89	No	No	0	6	8
12	R:R:F52	R:R:P96	32.2367	2.89	Yes	No	0	5	8
13	R:R:N98	R:R:Y360	10.6418	10.47	No	Yes	5	7	7
14	R:R:M121	R:R:N98	15.888	4.21	No	No	0	7	7
15	R:R:C91	R:R:F52	33.2269	5.59	No	Yes	6	7	5
16	R:R:C91	R:R:S55	35.1225	6.89	No	No	0	7	8
17	R:R:N59	R:R:S55	36.242	4.47	Yes	No	0	9	8
18	R:R:D87	R:R:N59	39.3541	6.73	Yes	Yes	2	9	9
19	R:R:D87	R:R:N366	51.0185	5.39	Yes	Yes	2	9	9
20	R:R:N366	R:R:Y370	80.3937	5.81	Yes	Yes	2	9	9
21	R:R:L80	R:R:Y370	62.0766	3.52	No	Yes	0	8	9
22	R:R:C371	R:R:L80	59.2717	6.35	No	No	0	8	8
23	R:R:C371	R:R:F377	50.0162	11.17	No	Yes	3	8	9
24	R:R:F377	R:R:V65	27.3381	9.18	Yes	No	3	9	8
25	R:R:T384	R:R:V65	17.5895	7.93	No	No	3	6	8
26	R:R:F377	R:R:L66	17.6542	3.65	Yes	No	0	9	7
27	R:R:L66	R:R:L81	10.0841	5.54	No	No	0	7	6
28	R:R:N69	R:R:T384	16.3043	5.85	Yes	No	0	6	6
29	R:R:N69	R:R:R71	11.7371	12.05	Yes	No	0	6	6
30	R:R:F79	R:R:I162	32.172	5.02	Yes	No	0	8	7
31	R:R:I162	R:R:S82	32.1558	6.19	No	No	0	7	9
32	R:R:S82	R:R:W166	24.222	3.71	No	No	0	9	9
33	R:R:F170	R:R:W166	24.0441	8.02	No	No	0	4	9
34	R:R:F170	R:R:T123	23.1752	6.49	No	No	10	4	6
35	R:R:M173	R:R:T123	25.8063	4.52	Yes	No	0	8	6
36	R:R:M173	R:R:Y176	29.6742	4.79	Yes	Yes	0	8	7
37	L:L:D7	R:R:Y176	96.5524	11.49	No	Yes	9	0	7
38	L:L:D7	R:R:H210	100	3.78	No	No	0	0	6
39	R:R:H210	R:R:Q206	98.4156	7.42	No	No	0	6	5
40	R:R:Q206	R:R:R336	97.6316	4.67	No	No	0	5	4
41	L:L:W5	R:R:R336	64.7563	9	Yes	No	1	0	4
42	L:L:W5	R:R:I352	29.6742	29.36	Yes	No	1	0	5
43	R:R:I352	R:R:I355	27.2977	4.42	No	Yes	1	5	6
44	R:R:I329	R:R:I355	25.2243	4.42	No	Yes	0	7	6
45	R:R:I329	R:R:L356	24.1533	4.28	No	No	0	7	6
46	R:R:L356	R:R:Y360	18.0503	10.55	No	Yes	5	6	7
47	R:R:R139	R:R:Y370	40.6111	6.17	No	Yes	0	9	9
48	R:R:I135	R:R:R139	31.8689	5.01	No	No	0	9	9
49	R:R:E138	R:R:F79	23.4177	7	Yes	Yes	0	9	8
50	R:R:V127	R:R:W166	15.605	18.39	No	No	0	8	9
51	R:R:D87	R:R:L90	10.2296	4.07	Yes	No	0	9	8
52	L:L:G4	L:L:W5	35.7732	4.22	No	Yes	1	0	0
53	L:L:G4	R:R:R197	63.0951	6	No	No	1	0	4
54	R:R:M195	R:R:R197	34.4111	16.13	Yes	No	1	4	4
55	R:R:M195	R:R:V183	26.9137	3.04	Yes	No	0	4	3
56	R:R:P184	R:R:V183	21.5949	3.53	No	No	0	1	3
57	R:R:N194	R:R:P184	18.9233	6.52	No	No	0	3	1
58	L:L:F8	R:R:Y176	93.2665	5.16	Yes	Yes	0	0	7
59	L:L:F8	R:R:V125	46.6252	3.93	Yes	No	0	0	7
60	R:R:V125	R:R:W326	46.6818	4.9	No	Yes	0	7	8
61	L:L:F8	R:R:F330	47.7973	5.36	Yes	No	0	0	7
62	R:R:F330	R:R:W326	47.967	7.02	No	Yes	0	7	8
63	R:R:S169	R:R:V127	21.2473	3.23	No	No	0	8	8
64	R:R:S126	R:R:S169	19.5134	3.26	No	No	0	7	8
65	R:R:L217	R:R:S126	12.4121	4.5	No	No	11	7	7
66	R:R:F322	R:R:W326	31.3313	7.02	No	Yes	0	9	8
67	R:R:F322	R:R:M225	30.0946	8.71	No	No	0	9	8
68	R:R:M225	R:R:S136	29.5004	7.67	No	Yes	0	8	9
69	R:R:R139	R:R:Y229	23.1994	8.23	No	Yes	0	9	9
70	R:R:S136	R:R:Y229	26.7723	3.82	Yes	Yes	0	9	9
71	R:R:S136	R:R:V133	11.9635	1.62	Yes	No	0	9	7
72	R:R:E138	R:R:Q153	16.8297	11.47	Yes	No	0	9	7
73	R:R:G141	R:R:K145	10.9692	1.74	No	Yes	0	6	6
74	R:R:G141	R:R:S149	12.1575	1.86	No	No	0	6	8
75	R:R:Q153	R:R:S149	13.3376	8.66	No	No	0	7	8
76	R:R:I216	R:R:L217	10.7227	4.28	No	No	0	5	7
77	R:R:F198	R:R:L200	13.3174	6.09	Yes	Yes	0	5	4
78	L:L:?2	R:R:R197	26.2994	15.68	Yes	No	1	0	4
79	R:R:L347	R:R:W335	13.6004	4.56	No	Yes	0	5	5
80	L:L:W5	R:R:L347	15.0715	5.69	Yes	No	0	0	5
81	R:R:V319	R:R:Y229	16.765	5.05	No	Yes	0	8	9
82	R:R:F323	R:R:V319	14.9341	2.62	No	No	0	6	8
83	R:R:L315	R:R:Y229	20.0671	15.24	No	Yes	0	8	9
84	R:R:I312	R:R:L236	11.1713	2.85	No	No	0	8	9
85	R:R:I369	R:R:Y370	18.1554	3.63	Yes	Yes	2	9	9
86	R:R:S362	R:R:W326	61.9594	8.65	No	Yes	2	9	8
87	R:R:A383	R:R:R71	10.0841	1.38	No	No	0	5	6
88	R:R:Q44	R:R:T350	15.6535	5.67	No	Yes	0	4	3
89	R:R:F79	R:R:I135	31.0323	3.77	Yes	No	0	8	9
90	R:R:N366	R:R:S362	62.6667	5.96	Yes	No	2	9	9
91	R:R:F198	R:R:Y176	12.2828	7.22	Yes	Yes	9	5	7
92	R:R:E344	R:R:R336	32.0629	12.79	Yes	No	1	1	4
93	L:L:G4	R:R:E344	29.8642	6.55	No	Yes	1	0	1

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:C94	R:R:M121	6.48	0	No	No	7	7	2	1
R:R:M121	R:R:N98	4.21	0	No	No	7	7	1	2
R:R:C114	R:R:F107	5.59	4	No	Yes	9	8	2	2
R:R:C196	R:R:F107	8.38	4	No	Yes	9	8	1	2
R:R:C114	R:R:C196	7.28	4	No	No	9	9	2	1
R:R:T118	R:R:Y176	3.75	0	No	Yes	6	7	2	1
L:L:M6	R:R:M121	4.33	0	No	No	0	7	0	1
R:R:V125	R:R:W326	4.9	0	No	Yes	7	8	1	2
L:L:F8	R:R:V125	3.93	0	Yes	No	0	7	0	1
R:R:M173	R:R:Y176	4.79	0	Yes	Yes	8	7	2	1
R:R:F198	R:R:Y176	7.22	9	Yes	Yes	5	7	1	1
L:L:D7	R:R:Y176	11.49	9	No	Yes	0	7	0	1
L:L:F8	R:R:Y176	5.16	0	Yes	Yes	0	7	0	1
R:R:F198	R:R:S180	3.96	9	Yes	No	5	6	1	2
R:R:A193	R:R:F185	4.16	0	No	No	3	4	2	1
R:R:F185	R:R:M195	8.71	1	No	Yes	4	4	1	1
L:L:?2	R:R:F185	6.99	1	Yes	No	0	4	0	1
R:R:M195	R:R:R197	16.13	1	Yes	No	4	4	1	1
L:L:?2	R:R:M195	5.07	1	Yes	Yes	0	4	0	1
L:L:M6	R:R:C196	6.48	0	No	No	0	9	0	1
L:L:?2	R:R:R197	15.68	1	Yes	No	0	4	0	1
L:L:G4	R:R:R197	6	1	No	No	0	4	0	1
R:R:F198	R:R:L200	6.09	9	Yes	Yes	5	4	1	2
L:L:D7	R:R:F198	13.14	9	No	Yes	0	5	0	1
R:R:H210	R:R:Q206	7.42	0	No	No	6	5	1	2
R:R:Q206	R:R:R336	4.67	0	No	No	5	4	2	1
R:R:A337	R:R:H210	4.39	0	No	No	6	6	2	1
L:L:D7	R:R:H210	3.78	9	No	No	0	6	0	1
R:R:F330	R:R:L214	3.65	0	No	No	7	7	1	2
R:R:F330	R:R:W326	7.02	0	No	Yes	7	8	1	2
L:L:F8	R:R:F330	5.36	0	Yes	No	0	7	0	1
L:L:F8	R:R:N333	3.62	0	Yes	No	0	7	0	1
R:R:L347	R:R:W335	4.56	0	No	Yes	5	5	1	2
R:R:E344	R:R:R336	12.79	1	Yes	No	1	4	1	1
L:L:W5	R:R:R336	9	1	Yes	No	0	4	0	1
R:R:E344	R:R:T340	5.64	1	Yes	No	1	2	1	2
L:L:G4	R:R:E344	6.55	1	No	Yes	0	1	0	1
L:L:W5	R:R:E344	5.45	1	Yes	Yes	0	1	0	1
L:L:W5	R:R:L347	5.69	1	Yes	No	0	5	0	1
L:L:M3	R:R:S348	4.6	1	Yes	No	0	5	0	1
R:R:I352	R:R:I355	4.42	1	No	Yes	5	6	1	2
L:L:W5	R:R:I352	29.36	1	Yes	No	0	5	0	1
L:L:?2	R:R:P101	3.53	1	Yes	No	0	5	0	1
R:R:I100	R:R:P101	3.39	0	No	No	5	5	2	1
R:R:M195	R:R:V183	3.04	1	Yes	No	4	3	1	2
L:L:?2	R:R:N102	2.95	1	Yes	No	0	6	0	1
R:R:A332	R:R:I352	1.62	1	No	No	5	5	2	1
R:R:A332	R:R:I355	1.62	1	No	Yes	5	6	2	2
L:L:M3	R:R:R345	1.24	1	Yes	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7EZH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.62
Number of Linked Nodes	278
Number of Links	306
Number of Hubs	36
Number of Links mediated by Hubs	141
Number of Communities	11
Number of Nodes involved in Communities	58
Number of Links involved in Communities	70

Path Summary
Number Of Nodes in MetaPath	94
Number Of Links MetaPath	93
Number of Shortest Paths	57369
Length Of Smallest Path	3
Average Path Length	16.3553
Length of Longest Path	37
Minimum Path Strength	1.245
Average Path Strength	6.38106
Maximum Path Strength	17.525
Minimum Path Correlation	0.7
Average Path Correlation	0.933629
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	46.9828
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.1646
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • molecular transducer activity • cholecystokinin receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • cholecystokinin signaling pathway • head development • forebrain development • brain development • nervous system development • central nervous system development • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of biological quality • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • neuron migration • cellular developmental process • generation of neurons • neurogenesis • cell differentiation • cell migration • cell motility • axonogenesis • cell projection organization • plasma membrane bounded cell projection morphogenesis • cell development • neuron projection development • cell morphogenesis • cellular component organization • cell projection morphogenesis • neuron differentiation • neuron projection morphogenesis • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • axon development • cell morphogenesis involved in neuron differentiation • anatomical structure morphogenesis • neuron development • G-protein beta-subunit binding • fibroblast proliferation • molecular function activator activity • signaling receptor binding • signaling receptor activator activity • hormone activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • neuropeptide activity • neuropeptide hormone activity • peptide hormone receptor binding • hormone receptor binding • behavior • eating behavior • feeding behavior • digestion • axon
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	TYS
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	TYS
Name	O-SULFO-L-TYROSINE
Synonyms
Identifier
Formula	C9 H11 N O6 S
Molecular Weight	261.252
SMILES
PubChem	514186
Formal Charge	0
Total Atoms	28
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32238
Sequence	>7EZH_nogp_Chain_R E W Q P A V Q I L L Y S L I F L L S V L G N T L V I T V L I R N K R M R T V T N I F L L S L A V S D L M L C L F C M P F N L I P N L L K D F I F G S A V C K T T T Y F M G T S V S V S T F N L V A I S L E R Y G A I C K P L Q S R V W Q T K S H A L K V I A A T W C L S F T I M T P Y P I Y S N L V P F T K N N N Q T A N M C R F L L P N D V M Q Q S W H T F L L L I L F L I P G I V M M V A Y G L I S L E L Y Q G I K F E A S S N S S A A N L M A K K R V I R M L I V I V V L F F L C W M P I F S A N A W R A Y D T A S A E R R L S G T P I S F I L L L S Y T S S C V N P I I Y C F M N K R F R L G F M A T F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9BKK	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.51	2024-05-22	To be published
	9BKK (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.51	2024-05-22	To be published
	9BKJ	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.59	2024-05-22	To be published
	9BKJ (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.59	2024-05-22	To be published
	7XOV	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	SR146131	-	Gs/β1/γ2	3	2022-07-20	10.1038/s41421-022-00420-3
	7XOV (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	SR146131	-		3	2022-07-20	10.1038/s41421-022-00420-3
	7XOU	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	Gs/β1/γ2	3.2	2022-07-20	10.1038/s41421-022-00420-3
	7XOU (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		3.2	2022-07-20	10.1038/s41421-022-00420-3
	7F8X	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	NN9056	-	-	3	2021-12-29	10.1038/s41589-021-00866-8
	7F8Y	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Devazepide	-	-	2.5	2021-10-13	10.1038/s41589-021-00866-8
	7F8U	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Lintitript	-	-	2.8	2021-10-13	10.1038/s41589-021-00866-8
	7EZK	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1-Gs)/β1/γ2	3.1	2021-08-25	10.1038/s41589-021-00841-3
	7EZK (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		3.1	2021-08-25	10.1038/s41589-021-00841-3
	7EZM	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGsL-Gq)/β1/γ2	2.9	2021-08-25	10.1038/s41589-021-00841-3
	7EZM (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.9	2021-08-25	10.1038/s41589-021-00841-3
	7EZH	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	Gi1/β1/γ2	3.2	2021-08-25	10.1038/s41589-021-00841-3
	7EZH (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		3.2	2021-08-25	10.1038/s41589-021-00841-3
	7MBY	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.44	2021-05-26	10.1371/journal.pbio.3001295
	7MBY (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.44	2021-05-26	10.1371/journal.pbio.3001295
	7MBX	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	Gs/β1/γ1	1.95	2021-05-26	10.1371/journal.pbio.3001295
	7MBX (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		1.95	2021-05-26	10.1371/journal.pbio.3001295

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