psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q44	R:R:Y48	3.38	Yes	Yes	3	4	7
2	R:R:L99	R:R:Q44	3.99	No	Yes	3	6	4
3	R:R:N102	R:R:Q44	6.6	No	Yes	0	6	4
4	R:R:L103	R:R:Q44	3.99	Yes	Yes	3	5	4
5	R:R:Q44	R:R:S353	11.55	Yes	No	3	4	5
6	R:R:I45	R:R:L103	4.28	No	Yes	0	5	5
7	R:R:L99	R:R:Y48	17.58	No	Yes	3	6	7
8	R:R:S353	R:R:Y48	3.82	No	Yes	3	5	7
9	R:R:L357	R:R:Y48	16.41	No	Yes	0	7	7
10	R:R:Y360	R:R:Y48	3.97	Yes	Yes	0	7	7
11	R:R:I51	R:R:M95	5.83	No	Yes	0	7	7
12	R:R:I51	R:R:L357	7.14	No	No	0	7	7
13	R:R:I51	R:R:T361	4.56	No	No	0	7	5
14	R:R:F52	R:R:L53	3.65	Yes	No	0	5	4
15	R:R:F52	R:R:V56	7.87	Yes	No	0	5	6
16	R:R:C91	R:R:F52	4.19	No	Yes	4	7	5
17	R:R:F52	R:R:M95	7.46	Yes	Yes	4	5	7
18	R:R:F52	R:R:P96	4.33	Yes	No	0	5	8
19	R:R:N59	R:R:S55	4.47	Yes	No	0	9	8
20	R:R:C91	R:R:S55	6.89	No	No	0	7	8
21	R:R:C364	R:R:S55	3.44	No	No	0	7	8
22	R:R:D87	R:R:N59	6.73	Yes	Yes	0	9	9
23	R:R:L88	R:R:N59	6.87	No	Yes	0	7	9
24	R:R:N59	R:R:P367	4.89	Yes	No	0	9	9
25	R:R:F381	R:R:L61	7.31	No	No	0	7	7
26	R:R:A84	R:R:V62	3.39	No	No	0	9	9
27	R:R:C371	R:R:V62	5.12	No	No	0	8	9
28	R:R:I63	R:R:V85	4.61	No	No	0	7	6
29	R:R:F385	R:R:T64	3.89	Yes	No	0	6	4
30	R:R:F377	R:R:V65	6.55	Yes	Yes	0	9	8
31	R:R:T384	R:R:V65	7.93	No	Yes	0	6	8
32	R:R:L66	R:R:N77	4.12	No	No	0	7	9
33	R:R:L66	R:R:L81	5.54	No	No	0	7	6
34	R:R:R68	R:R:T384	3.88	No	No	0	5	6
35	R:R:M72	R:R:N69	8.41	No	No	0	8	6
36	R:R:K70	R:R:R73	3.71	No	No	0	7	8
37	R:R:F377	R:R:M72	3.73	Yes	No	0	9	8
38	R:R:N77	R:R:T74	10.24	No	No	0	9	7
39	R:R:A158	R:R:I78	4.87	No	No	0	7	5
40	R:R:I78	R:R:L159	5.71	No	No	0	5	5
41	R:R:A134	R:R:F79	4.16	No	Yes	0	8	8
42	R:R:F79	R:R:I135	3.77	Yes	No	0	8	9
43	R:R:E138	R:R:F79	4.66	Yes	Yes	0	9	8
44	R:R:F79	R:R:V161	5.24	Yes	No	0	8	6
45	R:R:F79	R:R:I162	6.28	Yes	No	0	8	7
46	R:R:L80	R:R:Y370	3.52	No	Yes	0	8	9
47	R:R:C371	R:R:L80	6.35	No	No	0	8	8
48	R:R:N131	R:R:S82	7.45	Yes	No	0	8	9
49	R:R:I162	R:R:S82	6.19	No	No	0	7	9
50	R:R:S82	R:R:W166	6.18	No	Yes	0	9	9
51	R:R:D87	R:R:L83	6.79	Yes	No	0	9	9
52	R:R:L83	R:R:N131	5.49	No	Yes	0	9	8
53	R:R:S86	R:R:V127	4.85	No	Yes	0	8	8
54	R:R:S128	R:R:S86	4.89	No	No	0	9	8
55	R:R:D87	R:R:S128	4.42	Yes	No	0	9	9
56	R:R:D87	R:R:S363	11.78	Yes	No	0	9	9
57	R:R:D87	R:R:N366	6.73	Yes	No	0	9	9
58	R:R:L88	R:R:L92	4.15	No	No	0	7	5
59	R:R:M89	R:R:W166	3.49	No	Yes	0	7	9
60	R:R:L90	R:R:S124	9.01	No	No	0	8	6
61	R:R:L90	R:R:S363	12.01	No	No	0	8	9
62	R:R:C91	R:R:M95	6.48	No	Yes	4	7	7
63	R:R:F93	R:R:T117	3.89	No	No	0	5	6
64	R:R:F120	R:R:F93	17.15	No	No	0	5	5
65	R:R:C94	R:R:M121	8.1	No	No	0	7	7
66	R:R:C94	R:R:Y360	13.44	No	Yes	0	7	7
67	R:R:M95	R:R:Y360	3.59	Yes	Yes	0	7	7
68	R:R:F97	R:R:P96	5.78	No	No	0	6	8
69	R:R:F97	R:R:T117	6.49	No	No	0	6	6
70	R:R:M121	R:R:N98	4.21	No	No	0	7	7
71	R:R:N98	R:R:Y360	8.14	No	Yes	0	7	7
72	L:L:M6	R:R:N98	14.02	No	No	0	0	7
73	R:R:L103	R:R:L99	6.92	Yes	No	3	5	6
74	R:R:I100	R:R:P101	3.39	No	No	0	5	5
75	R:R:F107	R:R:P101	4.33	Yes	No	0	8	5
76	L:L:?2	R:R:P101	5.89	Yes	No	0	0	5
77	R:R:D106	R:R:L104	5.43	No	No	0	4	4
78	L:L:?2	R:R:K105	8.09	Yes	No	0	0	4
79	R:R:D106	R:R:K187	5.53	No	No	0	4	2
80	R:R:F107	R:R:F109	9.65	Yes	Yes	0	8	6
81	R:R:F107	R:R:L182	3.65	Yes	No	0	8	5
82	R:R:C196	R:R:F107	5.59	No	Yes	0	9	8
83	R:R:F109	R:R:I108	7.54	Yes	No	0	6	4
84	R:R:F109	R:R:V113	5.24	Yes	No	0	6	5
85	R:R:K115	R:R:S111	4.59	No	No	7	5	4
86	R:R:N181	R:R:S111	5.96	No	No	7	5	4
87	R:R:L182	R:R:S111	4.5	No	No	0	5	4
88	R:R:C114	R:R:C196	7.28	No	No	0	9	9
89	R:R:K115	R:R:N181	8.39	No	No	7	5	5
90	R:R:F120	R:R:T116	3.89	No	No	0	5	4
91	R:R:M121	R:R:T118	4.52	No	No	0	7	6
92	R:R:T118	R:R:Y176	3.75	No	Yes	0	6	7
93	R:R:S180	R:R:T118	9.59	No	No	0	6	6
94	R:R:T123	R:R:Y119	4.99	No	Yes	8	6	6
95	R:R:F170	R:R:Y119	9.28	No	Yes	8	4	6
96	R:R:T174	R:R:Y119	4.99	No	Yes	0	4	6
97	R:R:P177	R:R:Y119	9.74	No	Yes	0	6	6
98	R:R:G122	R:R:M173	3.49	No	No	0	6	8
99	R:R:F170	R:R:T123	11.67	No	No	8	4	6
100	R:R:V125	R:R:W326	7.36	No	Yes	0	7	8
101	L:L:F8	R:R:V125	11.8	Yes	No	0	0	7
102	R:R:F130	R:R:S126	5.28	No	No	0	6	7
103	R:R:S126	R:R:S169	6.52	No	No	0	7	8
104	R:R:N131	R:R:V127	4.43	Yes	Yes	0	8	8
105	R:R:V127	R:R:W166	14.71	Yes	Yes	0	8	9
106	R:R:S169	R:R:V127	4.85	No	Yes	0	8	8
107	R:R:P221	R:R:T129	3.5	Yes	No	1	9	8
108	R:R:F322	R:R:T129	3.89	No	No	1	9	8
109	R:R:T129	R:R:W326	3.64	No	Yes	1	8	8
110	R:R:N131	R:R:T165	5.85	Yes	No	0	8	7
111	R:R:L132	R:R:N366	8.24	No	No	0	8	9
112	R:R:L132	R:R:Y370	5.86	No	Yes	0	8	9
113	R:R:P221	R:R:V133	3.53	Yes	No	0	9	7
114	R:R:I135	R:R:R139	6.26	No	No	6	9	9
115	R:R:I135	R:R:Y370	7.25	No	Yes	6	9	9
116	R:R:S136	R:R:Y229	6.36	No	Yes	0	9	9
117	R:R:E138	R:R:W152	6.54	Yes	Yes	2	9	5
118	R:R:E138	R:R:Q153	12.74	Yes	Yes	2	9	7
119	R:R:E138	R:R:H157	8.62	Yes	Yes	2	9	7
120	R:R:R139	R:R:Y229	7.2	No	Yes	0	9	9
121	R:R:R139	R:R:Y370	6.17	No	Yes	6	9	9
122	R:R:C144	R:R:Y140	9.41	No	No	0	7	8
123	R:R:L231	R:R:Y140	8.21	No	No	0	5	8
124	R:R:G141	R:R:K145	3.49	No	Yes	0	6	6
125	R:R:I143	R:R:I232	5.89	No	No	0	9	9
126	R:R:K145	R:R:Q148	5.42	Yes	No	0	6	5
127	R:R:K145	R:R:S149	6.12	Yes	No	2	6	8
128	R:R:K145	R:R:W152	4.64	Yes	Yes	2	6	5
129	R:R:S149	R:R:W152	3.71	No	Yes	2	8	5
130	R:R:Q153	R:R:S149	8.66	Yes	No	2	7	8
131	R:R:Q153	R:R:W152	16.43	Yes	Yes	2	7	5
132	R:R:H157	R:R:W152	8.46	Yes	Yes	2	7	5
133	R:R:S156	R:R:T154	4.8	No	No	0	5	8
134	R:R:H157	R:R:V161	5.54	Yes	No	0	7	6
135	R:R:F170	R:R:W166	4.01	No	Yes	0	4	9
136	R:R:I172	R:R:M173	4.37	No	No	0	6	8
137	R:R:M173	R:R:Y176	4.79	No	Yes	0	8	7
138	R:R:F198	R:R:Y176	23.73	Yes	Yes	1	5	7
139	R:R:W209	R:R:Y176	8.68	Yes	Yes	1	8	7
140	L:L:D7	R:R:Y176	5.75	Yes	Yes	1	0	7
141	L:L:F8	R:R:Y176	5.16	Yes	Yes	1	0	7
142	R:R:P201	R:R:Y179	5.56	No	No	0	5	5
143	R:R:L182	R:R:N194	17.85	No	No	0	5	3
144	R:R:P184	R:R:V183	3.53	No	No	0	1	3
145	R:R:F185	R:R:K187	6.2	No	No	0	4	2
146	R:R:A193	R:R:F185	5.55	No	No	0	3	4
147	R:R:F185	R:R:M195	8.71	No	No	0	4	4
148	R:R:N188	R:R:N189	8.17	No	No	0	1	4
149	R:R:N189	R:R:Q191	5.28	No	No	0	4	2
150	R:R:M195	R:R:R197	8.69	No	Yes	0	4	4
151	R:R:L199	R:R:R197	3.64	No	Yes	0	4	4
152	L:L:?2	R:R:R197	9.58	Yes	Yes	0	0	4
153	L:L:G4	R:R:R197	4.5	Yes	Yes	0	0	4
154	R:R:F198	R:R:L200	4.87	Yes	No	0	5	4
155	R:R:F198	R:R:W209	8.02	Yes	Yes	1	5	8
156	L:L:D7	R:R:F198	9.55	Yes	Yes	1	0	5
157	R:R:M205	R:R:P201	5.03	No	No	0	4	5
158	R:R:M205	R:R:N202	9.82	No	No	0	4	5
159	R:R:D203	R:R:Q206	7.83	No	No	0	2	5
160	R:R:D203	R:R:Q207	7.83	No	No	0	2	4
161	R:R:H210	R:R:Q206	4.95	Yes	No	0	6	5
162	R:R:Q207	R:R:Y338	14.65	No	No	0	4	5
163	R:R:H210	R:R:W209	7.41	Yes	Yes	1	6	8
164	R:R:F212	R:R:W209	5.01	No	Yes	0	5	8
165	R:R:L213	R:R:W209	7.97	No	Yes	0	7	8
166	R:R:H210	R:R:N333	5.1	Yes	No	1	6	7
167	R:R:A337	R:R:H210	4.39	No	Yes	0	6	6
168	L:L:D7	R:R:H210	5.04	Yes	Yes	1	0	6
169	R:R:F212	R:R:I216	7.54	No	No	0	5	5
170	R:R:L213	R:R:L217	5.54	No	No	0	7	7
171	R:R:F218	R:R:L214	3.65	Yes	No	1	8	7
172	R:R:L214	R:R:L219	5.54	No	No	1	7	6
173	R:R:F330	R:R:L214	3.65	Yes	No	1	7	7
174	R:R:F330	R:R:L217	7.31	Yes	No	1	7	7
175	L:L:F8	R:R:L217	3.65	Yes	No	1	0	7
176	R:R:F218	R:R:L219	3.65	Yes	No	1	8	6
177	R:R:F218	R:R:F323	7.5	Yes	No	0	8	6
178	R:R:F218	R:R:M327	3.73	Yes	No	0	8	6
179	R:R:F218	R:R:F330	6.43	Yes	Yes	1	8	7
180	R:R:I220	R:R:P221	3.39	No	Yes	0	6	9
181	R:R:M225	R:R:P221	3.35	No	Yes	0	8	9
182	R:R:F322	R:R:P221	5.78	No	Yes	1	9	9
183	R:R:M225	R:R:Y229	3.59	No	Yes	0	8	9
184	R:R:L315	R:R:Y229	11.72	No	Yes	0	8	9
185	R:R:I318	R:R:Y229	7.25	No	Yes	0	9	9
186	R:R:I312	R:R:S233	9.29	No	No	0	8	6
187	R:R:L315	R:R:S233	4.5	No	No	0	8	6
188	R:R:K308	R:R:L236	4.23	No	No	0	8	9
189	R:R:I312	R:R:L236	8.56	No	No	0	8	9
190	R:R:Q238	R:R:Y237	9.02	No	No	0	5	6
191	R:R:K308	R:R:L305	4.23	No	No	0	8	4
192	R:R:I318	R:R:Y370	4.84	No	Yes	0	9	9
193	R:R:F322	R:R:W326	6.01	No	Yes	1	9	8
194	R:R:C325	R:R:W326	3.92	No	Yes	1	8	8
195	R:R:C325	R:R:S362	3.44	No	No	1	8	9
196	R:R:F330	R:R:W326	9.02	Yes	Yes	1	7	8
197	R:R:S359	R:R:W326	4.94	No	Yes	0	7	8
198	R:R:S362	R:R:W326	8.65	No	Yes	1	9	8
199	R:R:M327	R:R:P328	3.35	No	No	0	6	9
200	R:R:I355	R:R:P328	3.39	No	No	0	6	9
201	R:R:I329	R:R:N333	4.25	No	No	0	7	7
202	R:R:I329	R:R:L356	4.28	No	No	0	7	6
203	R:R:I329	R:R:S359	6.19	No	No	0	7	7
204	L:L:F8	R:R:F330	4.29	Yes	Yes	1	0	7
205	L:L:D7	R:R:N333	5.39	Yes	No	1	0	7
206	R:R:D339	R:R:W335	6.7	No	Yes	0	4	5
207	R:R:A343	R:R:W335	7.78	No	Yes	0	4	5
208	R:R:L347	R:R:W335	3.42	Yes	Yes	0	5	5
209	R:R:R336	R:R:T340	3.88	No	No	0	4	2
210	L:L:W5	R:R:R336	16.99	Yes	No	0	0	4
211	R:R:E344	R:R:T340	8.47	No	No	0	1	2
212	L:L:G4	R:R:E344	4.91	Yes	No	0	0	1
213	R:R:L347	R:R:R346	3.64	Yes	No	0	5	4
214	R:R:I355	R:R:L347	4.28	No	Yes	0	6	5
215	L:L:M3	R:R:S348	4.6	No	Yes	0	0	5
216	L:L:G4	R:R:S348	3.71	Yes	Yes	9	0	5
217	L:L:W5	R:R:S348	4.94	Yes	Yes	9	0	5
218	R:R:P351	R:R:T350	5.25	No	No	0	4	3
219	R:R:I352	R:R:I355	4.42	No	No	0	5	6
220	L:L:W5	R:R:I352	23.49	Yes	No	0	0	5
221	R:R:F354	R:R:S353	9.25	No	No	0	4	5
222	R:R:L356	R:R:Y360	9.38	No	Yes	0	6	7
223	R:R:F372	R:R:I368	3.77	No	No	0	6	6
224	R:R:C371	R:R:F377	5.59	No	Yes	0	8	9
225	R:R:K375	R:R:L379	4.23	No	No	0	6	5
226	R:R:F381	R:R:F385	6.43	No	Yes	5	7	6
227	L:L:?2	L:L:D1	8.76	Yes	No	0	0	0
228	L:L:?2	L:L:M3	7.1	Yes	No	0	0	0
229	L:L:G4	L:L:W5	5.63	Yes	Yes	9	0	0
230	R:R:L200	R:R:P201	3.28	No	No	0	4	5
231	R:R:L358	R:R:P328	3.28	No	No	0	8	9
232	R:R:C364	R:R:L54	3.17	No	No	0	7	5
233	R:R:I369	R:R:V317	3.07	No	No	0	9	7
234	R:R:M89	R:R:V85	3.04	No	No	0	7	6
235	R:R:F323	R:R:G222	3.01	No	No	0	6	6
236	R:R:L66	R:R:V62	2.98	No	No	0	7	9
237	R:R:L137	R:R:V133	2.98	No	No	0	6	7
238	R:R:L231	R:R:V227	2.98	No	No	0	5	5
239	R:R:L236	R:R:V311	2.98	No	No	0	9	9
240	R:R:L321	R:R:V317	2.98	No	No	0	6	7
241	R:R:L324	R:R:V320	2.98	No	No	0	5	6
242	R:R:L88	R:R:T60	2.95	No	No	0	7	4
243	R:R:I63	R:R:I67	2.94	No	No	0	7	3
244	R:R:I318	R:R:I369	2.94	No	No	0	9	9
245	R:R:N77	R:R:T76	2.92	No	No	0	9	8
246	R:R:G141	R:R:Y140	2.9	No	No	0	6	8
247	R:R:F372	R:R:P367	2.89	No	No	0	6	9
248	R:R:I172	R:R:L168	2.85	No	No	0	6	5
249	R:R:I232	R:R:L315	2.85	No	No	0	9	8
250	R:R:P175	R:R:Y179	2.78	No	No	0	8	5
251	R:R:A158	R:R:F79	2.77	No	Yes	0	7	8
252	R:R:L215	R:R:L219	2.77	No	No	0	3	6
253	R:R:H157	R:R:T154	2.74	Yes	No	0	7	8
254	R:R:L147	R:R:Q148	2.66	No	No	0	7	5
255	R:R:E235	R:R:L234	2.65	No	No	0	6	4
256	R:R:F381	R:R:V65	2.62	No	Yes	5	7	8
257	R:R:F385	R:R:V65	2.62	Yes	Yes	5	6	8
258	R:R:R376	R:R:T74	2.59	No	No	0	7	7
259	R:R:V319	R:R:Y229	2.52	No	Yes	0	8	9
260	R:R:I67	R:R:R73	2.51	No	No	0	3	8
261	R:R:T211	R:R:Y338	2.5	No	No	0	6	5
262	R:R:F323	R:R:M226	2.49	No	No	0	6	6
263	R:R:M314	R:R:R313	2.48	No	No	0	9	7
264	R:R:K375	R:R:R378	2.48	No	No	0	6	9
265	R:R:S342	R:R:W335	2.47	No	Yes	0	4	5
266	R:R:F377	R:R:N374	2.42	Yes	No	0	9	9
267	R:R:N69	R:R:R71	2.41	No	No	0	6	6
268	R:R:Q40	R:R:W39	2.19	No	No	0	1	1
269	R:R:R345	R:R:R346	2.13	No	No	0	5	4
270	R:R:A383	R:R:G380	1.95	No	No	0	5	8
271	R:R:G230	R:R:S233	1.86	No	No	0	1	6
272	R:R:G349	R:R:S348	1.86	No	Yes	0	3	5
273	R:R:G380	R:R:M72	1.75	No	No	0	8	8
274	R:R:G58	R:R:L57	1.71	No	No	0	8	4
275	R:R:A228	R:R:S136	1.71	No	No	0	6	9
276	R:R:A158	R:R:V75	1.7	No	No	0	7	7
277	R:R:K145	R:R:P146	1.67	Yes	No	0	6	8
278	R:R:L103	R:R:P41	1.64	Yes	No	0	5	4
279	R:R:L347	R:R:P351	1.64	Yes	No	0	5	4
280	R:R:N194	R:R:P184	1.63	No	No	0	3	1
281	R:R:V133	R:R:V224	1.6	No	No	0	7	7
282	R:R:V319	R:R:V320	1.6	No	No	0	8	6
283	R:R:T361	R:R:V365	1.59	No	No	0	5	7
284	R:R:P41	R:R:Q40	1.58	No	No	0	4	1
285	R:R:A332	R:R:L347	1.58	No	Yes	0	5	5
286	R:R:I316	R:R:V320	1.54	No	No	0	7	6
287	R:R:M205	R:R:S208	1.53	No	No	0	4	4
288	R:R:K155	R:R:V75	1.52	No	No	0	4	7
289	R:R:A142	R:R:Q153	1.52	No	Yes	0	8	7
290	R:R:C144	R:R:E235	1.52	No	No	0	7	6
291	R:R:M314	R:R:V317	1.52	No	No	0	9	7
292	R:R:F109	R:R:G110	1.51	Yes	No	0	6	7
293	R:R:L47	R:R:V43	1.49	No	No	0	5	5
294	R:R:N202	R:R:V204	1.48	No	No	0	5	2
295	R:R:I369	R:R:M373	1.46	No	No	0	9	7
296	R:R:F385	R:R:P386	1.44	Yes	No	0	6	1
297	R:R:L357	R:R:L47	1.38	No	No	0	7	5
298	R:R:L50	R:R:L54	1.38	No	No	0	4	5
299	R:R:L57	R:R:L61	1.38	No	No	0	4	7
300	R:R:K187	R:R:Q191	1.36	No	No	0	2	2
301	R:R:I312	R:R:Y237	1.21	No	No	0	8	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Q44	5.902	5	3	4
2	R:R:Y48	9.032	5	3	7
3	R:R:F52	5.5	5	4	5
4	R:R:N59	5.74	4	0	9
5	R:R:V65	4.93	4	5	8
6	R:R:F79	4.48	6	0	8
7	R:R:D87	7.29	5	0	9
8	R:R:M95	5.84	4	4	7
9	R:R:L103	4.2075	4	3	5
10	R:R:F107	5.805	4	0	8
11	R:R:F109	5.985	4	0	6
12	R:R:Y119	7.25	4	8	6
13	R:R:V127	7.21	4	0	8
14	R:R:N131	5.805	4	0	8
15	R:R:E138	8.14	4	2	9
16	R:R:K145	4.268	5	2	6
17	R:R:W152	7.956	5	2	5
18	R:R:Q153	9.8375	4	2	7
19	R:R:H157	6.34	4	2	7
20	R:R:W166	7.0975	4	0	9
21	R:R:Y176	8.64333	6	1	7
22	R:R:R197	6.6025	4	0	4
23	R:R:F198	11.5425	4	1	5
24	R:R:W209	7.418	5	1	8
25	R:R:H210	5.378	5	1	6
26	R:R:F218	4.992	5	1	8
27	R:R:P221	3.91	5	1	9
28	R:R:Y229	6.44	6	0	9
29	R:R:W326	6.22	7	1	8
30	R:R:F330	6.14	5	1	7
31	R:R:W335	5.0925	4	0	5
32	R:R:L347	2.912	5	0	5
33	R:R:S348	3.7775	4	9	5
34	R:R:Y360	7.704	5	0	7
35	R:R:Y370	5.528	5	6	9
36	R:R:F377	4.5725	4	0	9
37	R:R:F385	3.595	4	5	6
38	L:L:?2	7.884	5	0	0
39	L:L:G4	4.6875	4	9	0
40	L:L:W5	12.7625	4	9	0
41	L:L:D7	6.4325	4	1	0
42	L:L:F8	6.225	4	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Y360	R:R:Y48	15.8998	3.97	Yes	Yes	0	7	7
2	R:R:M95	R:R:Y360	27.4321	3.59	Yes	Yes	0	7	7
3	R:R:C91	R:R:M95	24.5991	6.48	No	Yes	4	7	7
4	R:R:N59	R:R:S55	28.7795	4.47	Yes	No	0	9	8
5	R:R:C91	R:R:S55	28.7261	6.89	No	No	0	7	8
6	R:R:D87	R:R:N59	28.9421	6.73	Yes	Yes	0	9	9
7	R:R:F377	R:R:V65	17.2205	6.55	Yes	Yes	0	9	8
8	R:R:C371	R:R:F377	29.2116	5.59	No	Yes	0	8	9
9	R:R:C371	R:R:L80	44.1893	6.35	No	No	0	8	8
10	R:R:L80	R:R:Y370	45.7305	3.52	No	Yes	0	8	9
11	R:R:L132	R:R:Y370	20.6125	5.86	No	Yes	0	8	9
12	R:R:L132	R:R:N366	19.3497	8.24	No	No	0	8	9
13	R:R:D87	R:R:N366	18.6347	6.73	Yes	No	0	9	9
14	R:R:C371	R:R:V62	13.9109	5.12	No	No	0	8	9
15	R:R:S82	R:R:W166	15.2829	6.18	No	Yes	0	9	9
16	R:R:N131	R:R:S82	11.3074	7.45	Yes	No	0	8	9
17	R:R:L83	R:R:N131	12.6882	5.49	No	Yes	0	9	8
18	R:R:D87	R:R:L83	13.9978	6.79	Yes	No	0	9	9
19	R:R:L66	R:R:V62	10.5457	2.98	No	No	0	7	9
20	R:R:F79	R:R:I135	43.8508	3.77	Yes	No	0	8	9
21	R:R:F79	R:R:I162	21.3007	6.28	Yes	No	0	8	7
22	R:R:I162	R:R:S82	20.6414	6.19	No	No	0	7	9
23	R:R:E138	R:R:F79	22.3252	4.66	Yes	Yes	0	9	8
24	L:L:?2	R:R:P101	33.7305	5.89	Yes	No	0	0	5
25	L:L:?2	R:R:R197	20.3163	9.58	Yes	Yes	0	0	4
26	L:L:G4	R:R:R197	31.1626	4.5	Yes	Yes	0	0	4
27	L:L:G4	L:L:W5	32.9911	5.63	Yes	Yes	9	0	0
28	L:L:W5	R:R:I352	58.3051	23.49	Yes	No	0	0	5
29	R:R:I352	R:R:I355	59.2183	4.42	No	No	0	5	6
30	R:R:I355	R:R:P328	68.7951	3.39	No	No	0	6	9
31	R:R:M327	R:R:P328	70.4922	3.35	No	No	0	6	9
32	R:R:F218	R:R:M327	71.3341	3.73	Yes	No	0	8	6
33	R:R:F218	R:R:F330	76.1225	6.43	Yes	Yes	1	8	7
34	R:R:F330	R:R:W326	86.7171	9.02	Yes	Yes	1	7	8
35	R:R:S359	R:R:W326	21.9065	4.94	No	Yes	0	7	8
36	R:R:I329	R:R:S359	21.2695	6.19	No	No	0	7	7
37	R:R:I329	R:R:L356	20.3786	4.28	No	No	0	7	6
38	R:R:L356	R:R:Y360	19.8797	9.38	No	Yes	0	6	7
39	L:L:?2	L:L:M3	19.6815	7.1	Yes	No	0	0	0
40	L:L:M3	R:R:S348	20.6659	4.6	No	Yes	0	0	5
41	L:L:W5	R:R:S348	22.6503	4.94	Yes	Yes	9	0	5
42	R:R:F107	R:R:P101	29.5523	4.33	Yes	No	0	8	5
43	R:R:F107	R:R:L182	14.882	3.65	Yes	No	0	8	5
44	R:R:M121	R:R:T118	10.9065	4.52	No	No	0	7	6
45	R:R:T118	R:R:Y176	12.7372	3.75	No	Yes	0	6	7
46	R:R:V125	R:R:W326	14.1069	7.36	No	Yes	0	7	8
47	L:L:F8	R:R:Y176	32.5635	5.16	Yes	Yes	1	0	7
48	R:R:P221	R:R:T129	51.0846	3.5	Yes	No	1	9	8
49	R:R:T129	R:R:W326	51.1247	3.64	No	Yes	1	8	8
50	R:R:F322	R:R:P221	51.0846	5.78	No	Yes	1	9	9
51	R:R:F322	R:R:W326	51.1247	6.01	No	Yes	1	9	8
52	R:R:R139	R:R:Y370	25.2004	6.17	No	Yes	6	9	9
53	R:R:M225	R:R:P221	100	3.35	No	Yes	0	8	9
54	R:R:M225	R:R:Y229	99.5679	3.59	No	Yes	0	8	9
55	R:R:R139	R:R:Y229	61.8775	7.2	No	Yes	0	9	9
56	R:R:E138	R:R:W152	14.5657	6.54	Yes	Yes	2	9	5
57	R:R:K145	R:R:W152	12.559	4.64	Yes	Yes	2	6	5
58	R:R:L315	R:R:Y229	14.6437	11.72	No	Yes	0	8	9
59	R:R:F198	R:R:Y176	17.1158	23.73	Yes	Yes	1	5	7
60	R:R:I329	R:R:N333	10.3296	4.25	No	No	0	7	7
61	R:R:L200	R:R:P201	15.2762	3.28	No	No	0	4	5
62	R:R:F198	R:R:L200	17.441	4.87	Yes	No	0	5	4
63	R:R:I318	R:R:Y229	30.5857	7.25	No	Yes	0	9	9
64	R:R:I318	R:R:Y370	27.3563	4.84	No	Yes	0	9	9
65	R:R:L315	R:R:S233	11.1024	4.5	No	No	0	8	6
66	R:R:I355	R:R:L347	11.245	4.28	No	Yes	0	6	5
67	L:L:F8	R:R:V125	13.3385	11.8	Yes	No	0	0	7
68	L:L:F8	R:R:F330	20.4967	4.29	Yes	Yes	1	0	7
69	R:R:I135	R:R:R139	36.2316	6.26	No	No	6	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:M121	R:R:N98	4.21	0	No	No	7	7	2	1
R:R:N98	R:R:Y360	8.14	0	No	Yes	7	7	1	2
L:L:M6	R:R:N98	14.02	0	No	No	0	7	0	1
R:R:I100	R:R:P101	3.39	0	No	No	5	5	2	1
R:R:F107	R:R:P101	4.33	0	Yes	No	8	5	2	1
L:L:?2	R:R:P101	5.89	0	Yes	No	0	5	0	1
L:L:?2	R:R:K105	8.09	0	Yes	No	0	4	0	1
R:R:M121	R:R:T118	4.52	0	No	No	7	6	2	2
R:R:T118	R:R:Y176	3.75	0	No	Yes	6	7	2	1
R:R:V125	R:R:W326	7.36	0	No	Yes	7	8	1	2
L:L:F8	R:R:V125	11.8	1	Yes	No	0	7	0	1
R:R:M173	R:R:Y176	4.79	0	No	Yes	8	7	2	1
R:R:F198	R:R:Y176	23.73	1	Yes	Yes	5	7	1	1
R:R:W209	R:R:Y176	8.68	1	Yes	Yes	8	7	2	1
L:L:D7	R:R:Y176	5.75	1	Yes	Yes	0	7	0	1
L:L:F8	R:R:Y176	5.16	1	Yes	Yes	0	7	0	1
R:R:M195	R:R:R197	8.69	0	No	Yes	4	4	2	1
R:R:L199	R:R:R197	3.64	0	No	Yes	4	4	2	1
L:L:?2	R:R:R197	9.58	0	Yes	Yes	0	4	0	1
L:L:G4	R:R:R197	4.5	9	Yes	Yes	0	4	0	1
R:R:F198	R:R:L200	4.87	1	Yes	No	5	4	1	2
R:R:F198	R:R:W209	8.02	1	Yes	Yes	5	8	1	2
L:L:D7	R:R:F198	9.55	1	Yes	Yes	0	5	0	1
R:R:H210	R:R:Q206	4.95	1	Yes	No	6	5	1	2
R:R:H210	R:R:W209	7.41	1	Yes	Yes	6	8	1	2
R:R:L213	R:R:W209	7.97	0	No	Yes	7	8	2	2
R:R:H210	R:R:N333	5.1	1	Yes	No	6	7	1	1
R:R:A337	R:R:H210	4.39	0	No	Yes	6	6	2	1
L:L:D7	R:R:H210	5.04	1	Yes	Yes	0	6	0	1
R:R:L213	R:R:L217	5.54	0	No	No	7	7	2	1
R:R:F218	R:R:L214	3.65	1	Yes	No	8	7	2	2
R:R:F330	R:R:L214	3.65	1	Yes	No	7	7	1	2
R:R:F330	R:R:L217	7.31	1	Yes	No	7	7	1	1
L:L:F8	R:R:L217	3.65	1	Yes	No	0	7	0	1
R:R:F218	R:R:F330	6.43	1	Yes	Yes	8	7	2	1
R:R:F330	R:R:W326	9.02	1	Yes	Yes	7	8	1	2
R:R:I329	R:R:N333	4.25	0	No	No	7	7	2	1
L:L:F8	R:R:F330	4.29	1	Yes	Yes	0	7	0	1
L:L:D7	R:R:N333	5.39	1	Yes	No	0	7	0	1
R:R:R336	R:R:T340	3.88	0	No	No	4	2	1	2
L:L:W5	R:R:R336	16.99	9	Yes	No	0	4	0	1
R:R:E344	R:R:T340	8.47	0	No	No	1	2	1	2
L:L:G4	R:R:E344	4.91	9	Yes	No	0	1	0	1
L:L:M3	R:R:S348	4.6	0	No	Yes	0	5	0	1
L:L:G4	R:R:S348	3.71	9	Yes	Yes	0	5	0	1
L:L:W5	R:R:S348	4.94	9	Yes	Yes	0	5	0	1
R:R:I352	R:R:I355	4.42	0	No	No	5	6	1	2
L:L:W5	R:R:I352	23.49	9	Yes	No	0	5	0	1
R:R:G349	R:R:S348	1.86	0	No	Yes	3	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7MBY_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.35
Number of Linked Nodes	266
Number of Links	301
Number of Hubs	42
Number of Links mediated by Hubs	157
Number of Communities	9
Number of Nodes involved in Communities	47
Number of Links involved in Communities	61

Path Summary
Number Of Nodes in MetaPath	70
Number Of Links MetaPath	69
Number of Shortest Paths	84821
Length Of Smallest Path	3
Average Path Length	16.0276
Length of Longest Path	33
Minimum Path Strength	1.435
Average Path Strength	5.8615
Maximum Path Strength	16.995
Minimum Path Correlation	0.7
Average Path Correlation	0.922444
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	42.213
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.486
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • hormone activity • molecular function activator activity • signaling receptor binding • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • neuropeptide activity • neuropeptide hormone activity • peptide hormone receptor binding • hormone receptor binding • cholecystokinin signaling pathway • developmental process • multicellular organismal process • neuron migration • cellular developmental process • nervous system development • generation of neurons • neurogenesis • multicellular organism development • cell differentiation • anatomical structure development • cell migration • cell motility • system development • behavior • eating behavior • feeding behavior • axonogenesis • cell projection organization • plasma membrane bounded cell projection morphogenesis • cell development • neuron projection development • cell morphogenesis • cellular component organization • cell projection morphogenesis • neuron differentiation • neuron projection morphogenesis • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • axon development • cell morphogenesis involved in neuron differentiation • anatomical structure morphogenesis • neuron development • digestion • axon • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • molecular transducer activity • cholecystokinin receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • head development • forebrain development • animal organ development • brain development • central nervous system development • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of biological quality • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • cell-cell signaling • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • phospholipase C-activating G protein-coupled receptor signaling pathway • cytosol • nucleus • membrane-enclosed lumen • intracellular membrane-bounded organelle • intracellular organelle lumen • intracellular organelle • nucleoplasm • organelle lumen • nuclear lumen • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • establishment of protein localization • nitrogen compound transport • regulation of protein localization • regulation of peptide secretion • protein localization to extracellular region • peptide secretion • amide transport • intracellular protein localization • regulation of peptide hormone secretion • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • regulation of protein transport • protein secretion • regulation of protein secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • T cell migration • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cell cycle • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network • midbody • intracellular membraneless organelle • nucleolus • membraneless organelle • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • ciliary basal body
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	TYS
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	TYS
Name	O-SULFO-L-TYROSINE
Synonyms
Identifier
Formula	C9 H11 N O6 S
Molecular Weight	261.252
SMILES
PubChem	514186
Formal Charge	0
Total Atoms	28
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32238
Sequence	>7MBY_nogp_Chain_R E W Q P A V Q I L L Y S L I F L L S V L G N T L V I T V L I R N K R M R T V T N I F L L S L A V S D L M L C L F C M P F N L I P N L L K D F I F G S A V C K T T T Y F M G T S V S V S T F N L V A I S L E R Y G A I C K P L Q S R V W Q T K S H A L K V I A A T W C L S F T I M T P Y P I Y S N L V P F T K N N N Q T A N M C R F L L P N D V M Q Q S W H T F L L L I L F L I P G I V M M V A Y G L I S L E L Y Q L M A K K R V I R M L I V I V V L F F L C W M P I F S A N A W R A Y D T A S A E R R L S G T P I S F I L L L S Y T S S C V N P I I Y C F M N K R F R L G F M A T F P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XOU	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	Gs/β1/γ2	3.2	2022-07-20	doi.org/10.1038/s41421-022-00420-3
	7XOU (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		3.2	2022-07-20	doi.org/10.1038/s41421-022-00420-3
	7XOV	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	SR146131	-	Gs/β1/γ2	3	2022-07-20	doi.org/10.1038/s41421-022-00420-3
	7XOV (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	SR146131	-		3	2022-07-20	doi.org/10.1038/s41421-022-00420-3
	7EZH	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	Gi1/β1/γ2	3.2	2021-08-25	doi.org/10.1038/s41589-021-00841-3
	7EZH (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		3.2	2021-08-25	doi.org/10.1038/s41589-021-00841-3
	7EZK	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1-Gs)/β1/γ2	3.1	2021-08-25	doi.org/10.1038/s41589-021-00841-3
	7EZK (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		3.1	2021-08-25	doi.org/10.1038/s41589-021-00841-3
	7EZM	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGsL-Gq)/β1/γ2	2.9	2021-08-25	doi.org/10.1038/s41589-021-00841-3
	7EZM (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.9	2021-08-25	doi.org/10.1038/s41589-021-00841-3
	7F8U	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Lintitript	-	-	2.8	2021-10-13	doi.org/10.1038/s41589-021-00866-8
	7F8Y	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Devazepide	-	-	2.5	2021-10-13	doi.org/10.1038/s41589-021-00866-8
	7F8X	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	NN9056	-	-	3	2021-12-29	doi.org/10.1038/s41589-021-00866-8
	7MBX	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	Gs/β1/γ1	1.95	2021-05-26	doi.org/10.1371/journal.pbio.3001295
	7MBX (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		1.95	2021-05-26	doi.org/10.1371/journal.pbio.3001295
	7MBY	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.44	2021-05-26	doi.org/10.1371/journal.pbio.3001295
	7MBY (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.44	2021-05-26	doi.org/10.1371/journal.pbio.3001295
	9BKJ	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.59	2024-05-22	doi.org/10.1371/journal.pbio.3002673
	9BKJ (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.59	2024-05-22	doi.org/10.1371/journal.pbio.3002673
	9BKK	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.51	2024-05-22	doi.org/10.1371/journal.pbio.3002673
	9BKK (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.51	2024-05-22	doi.org/10.1371/journal.pbio.3002673

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