psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E38	R:R:Q40	8.92	No	Yes	0	3	1
2	R:R:Q40	R:R:W39	16.43	Yes	No	0	1	1
3	R:R:V43	R:R:W39	7.36	No	No	0	5	1
4	R:R:Q40	R:R:T350	8.5	Yes	Yes	0	1	3
5	R:R:Q44	R:R:T350	5.67	No	Yes	3	4	3
6	R:R:Q44	R:R:S353	10.11	No	No	0	4	5
7	R:R:F354	R:R:Q44	4.68	No	No	3	4	4
8	R:R:I45	R:R:L103	7.14	No	No	0	5	5
9	R:R:L357	R:R:L47	5.54	No	No	0	7	5
10	R:R:M95	R:R:Y48	5.99	Yes	Yes	0	7	7
11	R:R:L99	R:R:Y48	17.58	No	Yes	0	6	7
12	R:R:S353	R:R:Y48	6.36	No	Yes	0	5	7
13	R:R:L357	R:R:Y48	11.72	No	Yes	0	7	7
14	R:R:L50	R:R:L54	4.15	No	No	0	4	5
15	R:R:I51	R:R:M95	4.37	No	Yes	0	7	7
16	R:R:I51	R:R:L357	5.71	No	No	0	7	7
17	R:R:I51	R:R:T361	4.56	No	No	0	7	5
18	R:R:F52	R:R:V56	7.87	Yes	No	0	5	6
19	R:R:C91	R:R:F52	5.59	No	Yes	0	7	5
20	R:R:F52	R:R:M95	4.98	Yes	Yes	0	5	7
21	R:R:N59	R:R:S55	4.47	Yes	No	0	9	8
22	R:R:C91	R:R:S55	6.89	No	No	0	7	8
23	R:R:S363	R:R:S55	4.89	No	No	0	9	8
24	R:R:L88	R:R:V56	4.47	No	No	0	7	6
25	R:R:L57	R:R:L61	4.15	No	No	0	4	7
26	R:R:A84	R:R:N59	4.69	No	Yes	0	9	9
27	R:R:D87	R:R:N59	6.73	Yes	Yes	0	9	9
28	R:R:N59	R:R:P367	9.77	Yes	No	0	9	9
29	R:R:F372	R:R:L61	4.87	No	No	0	6	7
30	R:R:F381	R:R:L61	6.09	No	No	0	7	7
31	R:R:C371	R:R:V62	6.83	No	No	4	8	9
32	R:R:F377	R:R:V62	9.18	Yes	No	4	9	9
33	R:R:I63	R:R:L81	4.28	No	No	0	7	6
34	R:R:F377	R:R:V65	7.87	Yes	No	0	9	8
35	R:R:F381	R:R:V65	3.93	No	No	0	7	8
36	R:R:T384	R:R:V65	4.76	Yes	No	0	6	8
37	R:R:L66	R:R:N77	4.12	No	No	0	7	9
38	R:R:R68	R:R:T384	14.23	No	Yes	5	5	6
39	R:R:F385	R:R:R68	10.69	No	No	5	6	5
40	R:R:M72	R:R:N69	4.21	No	No	0	8	6
41	R:R:N69	R:R:T384	7.31	No	Yes	0	6	6
42	R:R:M72	R:R:N77	4.21	No	No	0	8	9
43	R:R:N77	R:R:T74	13.16	No	No	0	9	7
44	R:R:L80	R:R:T76	4.42	No	No	0	8	8
45	R:R:I78	R:R:K155	4.36	No	No	0	5	4
46	R:R:A134	R:R:F79	4.16	No	Yes	0	8	8
47	R:R:F79	R:R:I135	3.77	Yes	No	0	8	9
48	R:R:E138	R:R:F79	15.16	No	Yes	0	9	8
49	R:R:A158	R:R:F79	4.16	No	Yes	0	7	8
50	R:R:F79	R:R:V161	5.24	Yes	No	0	8	6
51	R:R:L80	R:R:Y370	5.86	No	Yes	0	8	9
52	R:R:N131	R:R:S82	7.45	No	No	0	8	9
53	R:R:I162	R:R:S82	7.74	No	No	0	7	9
54	R:R:S82	R:R:W166	6.18	No	No	0	9	9
55	R:R:D87	R:R:L83	9.5	Yes	No	0	9	9
56	R:R:L83	R:R:N131	4.12	No	No	0	9	8
57	R:R:S86	R:R:V127	6.46	No	Yes	0	8	8
58	R:R:D87	R:R:S128	5.89	Yes	No	0	9	9
59	R:R:D87	R:R:S363	4.42	Yes	No	0	9	9
60	R:R:D87	R:R:N366	6.73	Yes	Yes	0	9	9
61	R:R:L88	R:R:L92	5.54	No	No	0	7	5
62	R:R:M89	R:R:S124	4.6	No	No	0	7	6
63	R:R:C94	R:R:L90	4.76	No	No	0	7	8
64	R:R:L90	R:R:S124	6.01	No	No	0	8	6
65	R:R:F120	R:R:F93	15	No	No	0	5	5
66	R:R:C94	R:R:M121	6.48	No	Yes	0	7	7
67	R:R:C94	R:R:Y360	12.1	No	Yes	0	7	7
68	R:R:M95	R:R:Y360	5.99	Yes	Yes	0	7	7
69	R:R:F109	R:R:F97	8.57	Yes	No	0	6	6
70	R:R:F97	R:R:T117	16.86	No	No	0	6	6
71	R:R:M121	R:R:N98	4.21	Yes	No	0	7	7
72	R:R:L356	R:R:N98	4.12	No	No	6	6	7
73	R:R:N98	R:R:Y360	10.47	No	Yes	6	7	7
74	R:R:L103	R:R:L99	8.3	No	No	0	5	6
75	L:L:?2	R:R:P101	5.89	Yes	No	0	0	5
76	L:L:?2	R:R:K105	5.06	Yes	No	0	0	4
77	R:R:D106	R:R:K187	4.15	No	No	0	4	2
78	R:R:A193	R:R:D106	6.18	No	No	0	3	4
79	R:R:F107	R:R:F109	11.79	Yes	Yes	0	8	6
80	R:R:C114	R:R:F107	5.59	No	Yes	7	9	8
81	R:R:F107	R:R:L182	7.31	Yes	No	0	8	5
82	R:R:C196	R:R:F107	11.17	No	Yes	7	9	8
83	R:R:F109	R:R:I108	10.05	Yes	No	0	6	4
84	R:R:F109	R:R:V113	9.18	Yes	No	0	6	5
85	R:R:K115	R:R:S111	6.12	No	No	0	5	4
86	R:R:C114	R:R:C196	7.28	No	No	7	9	9
87	R:R:K115	R:R:S180	4.59	No	No	0	5	6
88	R:R:F120	R:R:T116	3.89	No	No	0	5	4
89	R:R:M121	R:R:T117	4.52	Yes	No	0	7	6
90	R:R:T118	R:R:Y176	3.75	No	Yes	0	6	7
91	R:R:S180	R:R:T118	4.8	No	No	0	6	6
92	R:R:T123	R:R:Y119	7.49	No	No	8	6	6
93	R:R:F170	R:R:Y119	11.35	No	No	8	4	6
94	R:R:P177	R:R:Y119	15.3	No	No	0	6	6
95	L:L:M6	R:R:M121	4.33	No	Yes	0	0	7
96	R:R:F170	R:R:T123	9.08	No	No	8	4	6
97	R:R:V125	R:R:W326	4.9	No	Yes	0	7	8
98	L:L:F8	R:R:V125	13.11	No	No	0	0	7
99	R:R:F130	R:R:S126	7.93	No	No	0	6	7
100	R:R:S126	R:R:S169	4.89	No	No	0	7	8
101	R:R:N131	R:R:V127	4.43	No	Yes	0	8	8
102	R:R:V127	R:R:W166	24.52	Yes	No	0	8	9
103	R:R:F130	R:R:T165	3.89	No	No	0	6	7
104	R:R:L132	R:R:N366	5.49	No	Yes	0	8	9
105	R:R:I135	R:R:R139	6.26	No	No	0	9	9
106	R:R:L137	R:R:S136	4.5	No	No	0	6	9
107	R:R:S136	R:R:Y229	5.09	No	Yes	0	9	9
108	R:R:L137	R:R:V224	4.47	No	No	0	6	7
109	R:R:R139	R:R:Y229	6.17	No	Yes	0	9	9
110	R:R:R139	R:R:Y370	7.2	No	Yes	0	9	9
111	R:R:C144	R:R:Y140	5.38	No	No	0	7	8
112	R:R:L231	R:R:Y140	8.21	No	No	0	5	8
113	R:R:I143	R:R:I232	5.89	No	No	10	9	9
114	R:R:K145	R:R:Q148	4.07	No	No	0	6	5
115	R:R:Q153	R:R:S149	10.11	No	No	0	7	8
116	R:R:Q153	R:R:W152	16.43	No	No	0	7	5
117	R:R:H157	R:R:W152	9.52	No	No	0	7	5
118	R:R:H157	R:R:V161	6.92	No	No	0	7	6
119	R:R:F170	R:R:W166	5.01	No	No	0	4	9
120	R:R:I172	R:R:M173	4.37	No	No	0	6	8
121	R:R:M173	R:R:Y176	5.99	No	Yes	0	8	7
122	R:R:P175	R:R:T174	5.25	No	No	0	8	4
123	R:R:P175	R:R:W209	8.11	No	Yes	0	8	8
124	R:R:F198	R:R:Y176	10.32	Yes	Yes	1	5	7
125	R:R:W209	R:R:Y176	5.79	Yes	Yes	1	8	7
126	L:L:D7	R:R:Y176	11.49	Yes	Yes	1	0	7
127	L:L:F8	R:R:Y176	6.19	No	Yes	0	0	7
128	R:R:I178	R:R:Y179	12.09	No	No	0	5	5
129	R:R:L200	R:R:Y179	7.03	Yes	No	1	4	5
130	R:R:P201	R:R:Y179	9.74	No	No	1	5	5
131	R:R:N181	R:R:V183	4.43	No	No	0	5	3
132	R:R:L182	R:R:N194	5.49	No	No	0	5	3
133	R:R:A193	R:R:F185	5.55	No	No	0	3	4
134	L:L:?2	R:R:F185	4.37	Yes	No	0	0	4
135	R:R:K187	R:R:N189	5.6	No	No	0	2	4
136	R:R:N189	R:R:Q191	3.96	No	No	0	4	2
137	R:R:M195	R:R:R197	17.37	No	No	2	4	4
138	L:L:?2	R:R:M195	4.06	Yes	No	2	0	4
139	L:L:?2	R:R:R197	13.07	Yes	No	2	0	4
140	L:L:G4	R:R:R197	6	No	No	0	0	4
141	R:R:F198	R:R:L200	12.18	Yes	Yes	1	5	4
142	R:R:F198	R:R:Q206	8.2	Yes	No	1	5	5
143	R:R:F198	R:R:W209	9.02	Yes	Yes	1	5	8
144	L:L:D7	R:R:F198	7.17	Yes	Yes	1	0	5
145	R:R:L200	R:R:P201	4.93	Yes	No	1	4	5
146	R:R:L200	R:R:M205	5.65	Yes	No	0	4	4
147	R:R:L200	R:R:Q206	5.32	Yes	No	1	4	5
148	R:R:N202	R:R:V204	4.43	No	No	0	5	2
149	R:R:D203	R:R:Q207	9.14	No	No	0	2	4
150	R:R:H210	R:R:Q206	12.36	Yes	No	0	6	5
151	R:R:Q207	R:R:Y338	6.76	No	No	0	4	5
152	R:R:H210	R:R:W209	4.23	Yes	Yes	0	6	8
153	R:R:L213	R:R:W209	12.53	No	Yes	0	7	8
154	R:R:A337	R:R:H210	4.39	No	Yes	0	6	6
155	L:L:D7	R:R:H210	11.35	Yes	Yes	0	0	6
156	R:R:T211	R:R:Y338	6.24	No	No	0	6	5
157	R:R:F212	R:R:I216	15.07	No	No	0	5	5
158	R:R:I216	R:R:L217	4.28	No	No	0	5	7
159	R:R:F330	R:R:L217	4.87	Yes	No	0	7	7
160	R:R:F218	R:R:M327	9.95	Yes	No	0	8	6
161	R:R:F218	R:R:F330	4.29	Yes	Yes	0	8	7
162	R:R:F322	R:R:M225	13.68	No	No	0	9	8
163	R:R:F323	R:R:M226	6.22	No	No	0	6	6
164	R:R:L315	R:R:Y229	14.07	Yes	Yes	0	8	9
165	R:R:I318	R:R:Y229	4.84	No	Yes	0	9	9
166	R:R:V319	R:R:Y229	3.79	No	Yes	0	8	9
167	R:R:L234	R:R:Q238	7.99	No	No	0	4	5
168	R:R:E235	R:R:R295	10.47	No	Yes	0	6	4
169	R:R:K241	R:R:Y237	10.75	No	No	0	5	6
170	R:R:Q238	R:R:R295	17.52	No	Yes	0	5	4
171	R:R:I240	R:R:L305	5.71	No	No	0	5	4
172	R:R:I240	R:R:K308	4.36	No	No	0	5	8
173	R:R:F242	R:R:R295	7.48	No	Yes	0	4	4
174	R:R:E243	R:R:Q246	5.1	Yes	No	0	5	5
175	R:R:E243	R:R:S300	8.62	Yes	No	0	5	5
176	R:R:E243	R:R:K308	6.75	Yes	No	0	5	8
177	R:R:S298	R:R:S300	4.89	No	No	0	4	5
178	R:R:K309	R:R:L305	5.64	No	No	0	6	4
179	R:R:K309	R:R:M306	4.32	No	No	0	6	5
180	R:R:R310	R:R:R313	10.66	No	No	0	8	7
181	R:R:I369	R:R:M314	4.37	No	No	0	9	9
182	R:R:M314	R:R:M373	4.33	No	No	0	9	7
183	R:R:I318	R:R:I369	4.42	No	No	0	9	9
184	R:R:I318	R:R:Y370	6.04	No	Yes	0	9	9
185	R:R:F322	R:R:W326	7.02	No	Yes	0	9	8
186	R:R:C325	R:R:W326	3.92	No	Yes	9	8	8
187	R:R:C325	R:R:S362	6.89	No	No	9	8	9
188	R:R:F330	R:R:W326	8.02	Yes	Yes	0	7	8
189	R:R:S362	R:R:W326	8.65	No	Yes	9	9	8
190	R:R:I355	R:R:P328	5.08	No	No	0	6	9
191	R:R:F330	R:R:I329	3.77	Yes	No	0	7	7
192	R:R:I329	R:R:S359	4.64	No	No	0	7	7
193	L:L:F8	R:R:F330	4.29	No	Yes	0	0	7
194	L:L:W5	R:R:N333	4.52	Yes	No	0	0	7
195	L:L:D7	R:R:N333	5.39	Yes	No	0	0	7
196	R:R:D339	R:R:W335	7.82	No	Yes	12	4	5
197	R:R:S342	R:R:W335	4.94	No	Yes	12	4	5
198	R:R:A343	R:R:W335	9.08	No	Yes	0	4	5
199	R:R:R346	R:R:W335	4	No	Yes	0	4	5
200	R:R:L347	R:R:W335	5.69	No	Yes	0	5	5
201	R:R:E344	R:R:R336	4.65	No	No	0	1	4
202	L:L:W5	R:R:R336	19.99	Yes	No	0	0	4
203	L:L:D7	R:R:R336	4.76	Yes	No	0	0	4
204	R:R:D339	R:R:S342	4.42	No	No	12	4	4
205	R:R:E344	R:R:T340	4.23	No	No	0	1	2
206	L:L:G4	R:R:E344	8.19	No	No	0	0	1
207	L:L:M3	R:R:S348	6.13	No	No	0	0	5
208	R:R:F354	R:R:T350	3.89	No	Yes	3	4	3
209	R:R:I352	R:R:I355	4.42	No	No	11	5	6
210	L:L:W5	R:R:I352	24.66	Yes	No	0	0	5
211	R:R:L356	R:R:Y360	9.38	No	Yes	6	6	7
212	R:R:S359	R:R:Y360	10.17	No	Yes	0	7	7
213	R:R:N366	R:R:S362	5.96	Yes	No	0	9	9
214	R:R:N366	R:R:Y370	4.65	Yes	Yes	0	9	9
215	R:R:C371	R:R:F377	15.36	No	Yes	4	8	9
216	R:R:F372	R:R:F377	4.29	No	Yes	0	6	9
217	R:R:K375	R:R:R378	6.19	No	No	0	6	9
218	R:R:K375	R:R:L379	4.23	No	No	0	6	5
219	R:R:F385	R:R:T384	3.89	No	Yes	5	6	6
220	L:L:?2	L:L:D1	8.76	Yes	No	2	0	0
221	L:L:D1	L:L:M3	9.7	No	No	2	0	0
222	L:L:?2	L:L:M3	7.1	Yes	No	2	0	0
223	L:L:?2	L:L:M6	4.06	Yes	No	0	0	0
224	R:R:F93	R:R:M89	3.73	No	No	0	5	7
225	R:R:K70	R:R:R73	3.71	No	No	0	7	8
226	R:R:G141	R:R:S149	3.71	No	No	0	6	8
227	R:R:G230	R:R:S233	3.71	No	No	0	1	6
228	R:R:F218	R:R:L214	3.65	Yes	No	0	8	7
229	R:R:N374	R:R:R376	3.62	No	No	0	9	7
230	R:R:P221	R:R:V133	3.53	No	No	0	9	7
231	R:R:F242	R:R:Q246	3.51	No	No	0	4	5
232	R:R:P221	R:R:T129	3.5	No	No	0	9	8
233	R:R:Q246	R:R:R297	3.5	No	No	0	5	4
234	R:R:P351	R:R:T350	3.5	No	Yes	0	4	3
235	R:R:G380	R:R:M72	3.49	No	No	0	8	8
236	R:R:G122	R:R:M173	3.49	No	No	0	6	8
237	R:R:D339	R:R:Y338	3.45	No	No	0	4	5
238	R:R:A228	R:R:S136	3.42	No	No	0	6	9
239	R:R:A303	R:R:S301	3.42	No	No	0	4	4
240	L:L:W5	R:R:L347	3.42	Yes	No	0	0	5
241	R:R:A84	R:R:V62	3.39	No	No	0	9	9
242	R:R:A158	R:R:V75	3.39	No	No	0	7	7
243	R:R:I100	R:R:P101	3.39	No	No	0	5	5
244	R:R:I220	R:R:P221	3.39	No	No	0	6	9
245	R:R:N194	R:R:P184	3.26	No	No	0	3	1
246	R:R:S169	R:R:V127	3.23	No	Yes	0	8	8
247	R:R:S156	R:R:T154	3.2	No	No	0	5	8
248	R:R:P41	R:R:Q40	3.16	No	Yes	0	4	1
249	R:R:I63	R:R:V85	3.07	No	No	0	7	6
250	R:R:M327	R:R:S331	3.07	No	No	0	6	6
251	R:R:I369	R:R:V365	3.07	No	No	0	9	7
252	R:R:K248	R:R:S245	3.06	No	No	0	3	3
253	R:R:K155	R:R:V75	3.04	No	No	0	4	7
254	R:R:M195	R:R:V183	3.04	No	No	0	4	3
255	R:R:F372	R:R:G58	3.01	No	No	0	6	8
256	R:R:F323	R:R:G222	3.01	No	No	0	6	6
257	R:R:L315	R:R:S233	3	Yes	No	0	8	6
258	R:R:G239	R:R:R295	3	No	Yes	0	7	4
259	R:R:L231	R:R:V227	2.98	No	No	0	5	5
260	R:R:L236	R:R:V311	2.98	Yes	No	0	9	9
261	R:R:N304	R:R:S300	2.98	No	No	0	4	5
262	R:R:N304	R:R:S301	2.98	No	No	0	4	4
263	R:R:L315	R:R:V311	2.98	Yes	No	0	8	9
264	R:R:L321	R:R:V317	2.98	No	No	0	6	7
265	R:R:L321	R:R:V365	2.98	No	No	0	6	7
266	R:R:L88	R:R:T60	2.95	No	No	0	7	4
267	L:L:?2	R:R:N102	2.95	Yes	No	0	0	6
268	R:R:I63	R:R:I67	2.94	No	No	0	7	3
269	R:R:I368	R:R:M373	2.92	No	No	0	6	7
270	R:R:G141	R:R:Y140	2.9	No	No	0	6	8
271	R:R:F52	R:R:P96	2.89	Yes	No	0	5	8
272	R:R:I143	R:R:L236	2.85	No	Yes	10	9	9
273	R:R:I172	R:R:L168	2.85	No	No	0	6	5
274	R:R:I232	R:R:L236	2.85	No	Yes	10	9	9
275	R:R:I232	R:R:L315	2.85	No	Yes	0	9	8
276	R:R:I312	R:R:L236	2.85	No	Yes	0	8	9
277	R:R:L46	R:R:L47	2.77	No	No	0	4	5
278	R:R:L66	R:R:L81	2.77	No	No	0	7	6
279	R:R:L215	R:R:L219	2.77	No	No	0	3	6
280	R:R:E243	R:R:K247	2.7	Yes	No	0	5	3
281	R:R:F323	R:R:V319	2.62	No	No	0	6	8
282	R:R:F322	R:R:T129	2.59	No	No	0	9	8
283	R:R:F218	R:R:L219	2.44	Yes	No	0	8	6
284	R:R:F377	R:R:N374	2.42	Yes	No	0	9	9
285	R:R:G349	R:R:P351	2.03	No	No	0	3	4
286	R:R:A383	R:R:G380	1.95	No	No	0	5	8
287	R:R:G141	R:R:K145	1.74	No	No	0	6	6
288	R:R:G110	R:R:L182	1.71	No	No	0	7	5
289	R:R:A302	R:R:S301	1.71	No	No	0	4	4
290	R:R:K145	R:R:P146	1.67	No	No	0	6	8
291	R:R:C364	R:R:I368	1.64	No	No	0	7	6
292	R:R:A142	R:R:I143	1.62	No	No	0	8	9
293	R:R:A332	R:R:I352	1.62	No	No	11	5	5
294	R:R:A332	R:R:I355	1.62	No	No	11	5	6
295	R:R:C364	R:R:L54	1.59	No	No	0	7	5
296	R:R:C325	R:R:L324	1.59	No	No	0	8	5
297	R:R:A334	R:R:L214	1.58	No	No	0	6	7
298	R:R:I223	R:R:V227	1.54	No	No	0	4	5
299	R:R:I316	R:R:V320	1.54	No	No	0	7	6
300	R:R:I240	R:R:I312	1.47	No	No	0	5	8
301	R:R:I312	R:R:I316	1.47	No	No	0	8	7
302	R:R:I108	R:R:L104	1.43	No	No	0	4	4
303	R:R:Q191	R:R:T192	1.42	No	No	0	2	3
304	R:R:M205	R:R:N202	1.4	No	No	0	4	5
305	R:R:L324	R:R:L358	1.38	No	No	0	5	8
306	R:R:A341	R:R:R345	1.38	No	No	0	1	5
307	R:R:L147	R:R:Q148	1.33	No	No	0	7	5
308	R:R:F242	R:R:S245	1.32	No	No	0	4	3
309	R:R:I78	R:R:R73	1.25	No	No	0	5	8
310	R:R:K70	R:R:R71	1.24	No	No	0	7	6
311	R:R:M306	R:R:R313	1.24	No	No	0	5	7
312	R:R:M314	R:R:R310	1.24	No	No	0	9	8
313	R:R:M382	R:R:R378	1.24	No	No	0	5	9
314	R:R:F381	R:R:M382	1.24	No	No	0	7	5
315	R:R:N294	R:R:R295	1.21	No	Yes	0	1	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Q40	9.2525	4	0	1
2	R:R:Y48	10.4125	4	0	7
3	R:R:F52	5.3325	4	0	5
4	R:R:N59	6.415	4	0	9
5	R:R:F79	6.498	5	0	8
6	R:R:D87	6.654	5	0	9
7	R:R:M95	5.3325	4	0	7
8	R:R:F107	8.965	4	7	8
9	R:R:F109	9.8975	4	0	6
10	R:R:M121	4.885	4	0	7
11	R:R:V127	9.66	4	0	8
12	R:R:Y176	7.255	6	1	7
13	R:R:F198	9.378	5	1	5
14	R:R:L200	7.022	5	1	4
15	R:R:W209	7.936	5	1	8
16	R:R:H210	8.0825	4	0	6
17	R:R:F218	5.0825	4	0	8
18	R:R:Y229	6.792	5	0	9
19	R:R:L236	2.8825	4	10	9
20	R:R:E243	5.7925	4	0	5
21	R:R:R295	7.936	5	0	4
22	R:R:L315	5.725	4	0	8
23	R:R:W326	6.502	5	9	8
24	R:R:F330	5.048	5	0	7
25	R:R:W335	6.306	5	12	5
26	R:R:T350	5.39	4	3	3
27	R:R:Y360	9.622	5	6	7
28	R:R:N366	5.7075	4	0	9
29	R:R:Y370	5.9375	4	0	9
30	R:R:F377	7.824	5	4	9
31	R:R:T384	7.5475	4	5	6
32	L:L:?2	6.14667	9	2	0
33	L:L:W5	13.1475	4	0	0
34	L:L:D7	8.032	5	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S353	R:R:Y48	10.8261	6.36	No	Yes	0	5	7
2	R:R:M95	R:R:Y48	17.4559	5.99	Yes	Yes	0	7	7
3	R:R:F52	R:R:M95	28.2634	4.98	Yes	Yes	0	5	7
4	R:R:C91	R:R:F52	30.7002	5.59	No	Yes	0	7	5
5	R:R:C91	R:R:S55	31.1389	6.89	No	No	0	7	8
6	R:R:N59	R:R:S55	18.8154	4.47	Yes	No	0	9	8
7	R:R:D87	R:R:N59	30.8692	6.73	Yes	Yes	0	9	9
8	R:R:D87	R:R:N366	47.3981	6.73	Yes	Yes	0	9	9
9	R:R:N366	R:R:Y370	100	4.65	Yes	Yes	0	9	9
10	R:R:I318	R:R:Y370	47.1858	6.04	No	Yes	0	9	9
11	R:R:I318	R:R:I369	10.2556	4.42	No	No	0	9	9
12	R:R:S363	R:R:S55	13.3853	4.89	No	No	0	9	8
13	R:R:D87	R:R:S363	13.762	4.42	Yes	No	0	9	9
14	R:R:A84	R:R:N59	21.9947	4.69	No	Yes	0	9	9
15	R:R:A84	R:R:V62	21.3064	3.39	No	No	0	9	9
16	R:R:F377	R:R:V62	19.8788	9.18	Yes	No	4	9	9
17	R:R:F377	R:R:V65	14.8951	7.87	Yes	No	0	9	8
18	R:R:T384	R:R:V65	10.6106	4.76	Yes	No	0	6	8
19	R:R:R139	R:R:Y370	53.2359	7.2	No	Yes	0	9	9
20	R:R:I135	R:R:R139	18.4976	6.26	No	No	0	9	9
21	R:R:F79	R:R:I135	17.8233	3.77	Yes	No	0	8	9
22	R:R:F79	R:R:V161	10.9082	5.24	Yes	No	0	8	6
23	R:R:D87	R:R:L83	18.3519	9.5	Yes	No	0	9	9
24	R:R:L83	R:R:N131	17.4637	4.12	No	No	0	9	8
25	R:R:N131	R:R:V127	10.1456	4.43	No	Yes	0	8	8
26	R:R:M95	R:R:Y360	17.735	5.99	Yes	Yes	0	7	7
27	R:R:C94	R:R:Y360	20.9329	12.1	No	Yes	0	7	7
28	R:R:C94	R:R:M121	17.7102	6.48	No	Yes	0	7	7
29	R:R:N98	R:R:Y360	17.6218	10.47	No	Yes	6	7	7
30	R:R:M121	R:R:N98	17.2529	4.21	Yes	No	0	7	7
31	R:R:M121	R:R:T117	15.0517	4.52	Yes	No	0	7	6
32	R:R:F97	R:R:T117	13.9682	16.86	No	No	0	6	6
33	R:R:F109	R:R:F97	12.8211	8.57	Yes	No	0	6	6
34	L:L:?2	L:L:M6	20.2307	4.06	Yes	No	0	0	0
35	L:L:M6	R:R:M121	21.1003	4.33	No	Yes	0	0	7
36	R:R:S359	R:R:Y360	30.1576	10.17	No	Yes	0	7	7
37	R:R:I329	R:R:S359	30.3871	4.64	No	No	0	7	7
38	R:R:F330	R:R:I329	30.7203	3.77	Yes	No	0	7	7
39	L:L:F8	R:R:F330	31.6039	4.29	No	Yes	0	0	7
40	L:L:F8	R:R:Y176	56.5314	6.19	No	Yes	0	0	7
41	R:R:F330	R:R:W326	54.1691	8.02	Yes	Yes	0	7	8
42	R:R:V125	R:R:W326	26.2405	4.9	No	Yes	0	7	8
43	L:L:F8	R:R:V125	25.9739	13.11	No	No	0	0	7
44	R:R:R139	R:R:Y229	41.193	6.17	No	Yes	0	9	9
45	R:R:I318	R:R:Y229	39.1019	4.84	No	Yes	0	9	9
46	R:R:H157	R:R:V161	10.1998	6.92	No	No	0	7	6
47	R:R:L315	R:R:Y229	69.289	14.07	Yes	Yes	0	8	9
48	R:R:I232	R:R:L315	34.1911	2.85	No	Yes	0	9	8
49	L:L:D7	R:R:Y176	35.9861	11.49	Yes	Yes	1	0	7
50	R:R:L347	R:R:W335	17.1025	5.69	No	Yes	0	5	5
51	L:L:W5	R:R:L347	18.9875	3.42	Yes	No	0	0	5
52	L:L:W5	R:R:N333	13.6101	4.52	Yes	No	0	0	7
53	L:L:D7	R:R:N333	14.5107	5.39	Yes	No	0	0	7
54	L:L:W5	R:R:R336	14.6704	19.99	Yes	No	0	0	4
55	L:L:D7	R:R:R336	21.0073	4.76	Yes	No	0	0	4
56	R:R:L315	R:R:V311	31.807	2.98	Yes	No	0	8	9
57	R:R:L236	R:R:V311	30.6583	2.98	Yes	No	0	9	9
58	R:R:I312	R:R:L236	59.1077	2.85	No	Yes	0	8	9
59	R:R:I240	R:R:I312	52.0872	1.47	No	No	0	5	8
60	R:R:I240	R:R:K308	47.7841	4.36	No	No	0	5	8
61	R:R:E243	R:R:K308	45.4822	6.75	Yes	No	0	5	8
62	R:R:E243	R:R:Q246	26.5397	5.1	Yes	No	0	5	5
63	R:R:F242	R:R:Q246	21.7405	3.51	No	No	0	4	5
64	R:R:F242	R:R:R295	14.5185	7.48	No	Yes	0	4	4
65	R:R:I232	R:R:L236	30.6583	2.85	No	Yes	10	9	9
66	R:R:E243	R:R:S300	14.3944	8.62	Yes	No	0	5	5
67	R:R:S362	R:R:W326	78.8641	8.65	No	Yes	9	9	8
68	R:R:N366	R:R:S362	80.0499	5.96	Yes	No	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:C94	R:R:M121	6.48	0	No	Yes	7	7	2	1
R:R:M121	R:R:N98	4.21	0	Yes	No	7	7	1	2
L:L:?2	R:R:P101	5.89	2	Yes	No	0	5	0	1
L:L:?2	R:R:K105	5.06	2	Yes	No	0	4	0	1
R:R:M121	R:R:T117	4.52	0	Yes	No	7	6	1	2
R:R:T118	R:R:Y176	3.75	0	No	Yes	6	7	2	1
L:L:M6	R:R:M121	4.33	0	No	Yes	0	7	0	1
R:R:V125	R:R:W326	4.9	0	No	Yes	7	8	1	2
L:L:F8	R:R:V125	13.11	0	No	No	0	7	0	1
R:R:M173	R:R:Y176	5.99	0	No	Yes	8	7	2	1
R:R:F198	R:R:Y176	10.32	1	Yes	Yes	5	7	1	1
R:R:W209	R:R:Y176	5.79	1	Yes	Yes	8	7	2	1
L:L:D7	R:R:Y176	11.49	1	Yes	Yes	0	7	0	1
L:L:F8	R:R:Y176	6.19	0	No	Yes	0	7	0	1
R:R:A193	R:R:F185	5.55	0	No	No	3	4	2	1
L:L:?2	R:R:F185	4.37	2	Yes	No	0	4	0	1
R:R:M195	R:R:R197	17.37	2	No	No	4	4	1	1
L:L:?2	R:R:M195	4.06	2	Yes	No	0	4	0	1
L:L:?2	R:R:R197	13.07	2	Yes	No	0	4	0	1
L:L:G4	R:R:R197	6	0	No	No	0	4	0	1
R:R:F198	R:R:L200	12.18	1	Yes	Yes	5	4	1	2
R:R:F198	R:R:Q206	8.2	1	Yes	No	5	5	1	2
R:R:F198	R:R:W209	9.02	1	Yes	Yes	5	8	1	2
L:L:D7	R:R:F198	7.17	1	Yes	Yes	0	5	0	1
R:R:L200	R:R:Q206	5.32	1	Yes	No	4	5	2	2
R:R:H210	R:R:Q206	12.36	0	Yes	No	6	5	1	2
R:R:H210	R:R:W209	4.23	0	Yes	Yes	6	8	1	2
R:R:A337	R:R:H210	4.39	0	No	Yes	6	6	2	1
L:L:D7	R:R:H210	11.35	1	Yes	Yes	0	6	0	1
R:R:F330	R:R:L217	4.87	0	Yes	No	7	7	1	2
R:R:F218	R:R:F330	4.29	0	Yes	Yes	8	7	2	1
R:R:F330	R:R:W326	8.02	0	Yes	Yes	7	8	1	2
R:R:F330	R:R:I329	3.77	0	Yes	No	7	7	1	2
L:L:F8	R:R:F330	4.29	0	No	Yes	0	7	0	1
L:L:W5	R:R:N333	4.52	0	Yes	No	0	7	0	1
L:L:D7	R:R:N333	5.39	1	Yes	No	0	7	0	1
R:R:L347	R:R:W335	5.69	0	No	Yes	5	5	1	2
R:R:E344	R:R:R336	4.65	0	No	No	1	4	1	1
L:L:W5	R:R:R336	19.99	0	Yes	No	0	4	0	1
L:L:D7	R:R:R336	4.76	1	Yes	No	0	4	0	1
R:R:E344	R:R:T340	4.23	0	No	No	1	2	1	2
L:L:G4	R:R:E344	8.19	0	No	No	0	1	0	1
L:L:M3	R:R:S348	6.13	2	No	No	0	5	0	1
R:R:I352	R:R:I355	4.42	11	No	No	5	6	1	2
L:L:W5	R:R:I352	24.66	0	Yes	No	0	5	0	1
L:L:W5	R:R:L347	3.42	0	Yes	No	0	5	0	1
R:R:I100	R:R:P101	3.39	0	No	No	5	5	2	1
R:R:M195	R:R:V183	3.04	2	No	No	4	3	1	2
L:L:?2	R:R:N102	2.95	2	Yes	No	0	6	0	1
R:R:A332	R:R:I352	1.62	11	No	No	5	5	2	1
R:R:A332	R:R:I355	1.62	11	No	No	5	6	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7EZM_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.75
Number of Linked Nodes	289
Number of Links	315
Number of Hubs	34
Number of Links mediated by Hubs	137
Number of Communities	12
Number of Nodes involved in Communities	43
Number of Links involved in Communities	47

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	105285
Length Of Smallest Path	3
Average Path Length	16.8315
Length of Longest Path	33
Minimum Path Strength	1.24
Average Path Strength	6.30728
Maximum Path Strength	16.47
Minimum Path Correlation	0.7
Average Path Correlation	0.935497
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	48.6408
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.8428
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • molecular function activator activity • nucleoside-triphosphatase regulator activity • GTPase regulator activity • enzyme activator activity • GTPase activator activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • regulation of signaling • cell surface receptor signaling pathway • regulation of Wnt signaling pathway • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • regulation of signal transduction • regulation of response to stimulus • regulation of cell communication • Wnt signaling pathway • neuropeptide signaling pathway • multicellular organismal process • regulation of body fluid levels • wound healing • hemostasis • blood coagulation • response to stress • coagulation • regulation of biological quality • response to wounding • regulation of protein stability • protein stabilization • phospholipase C-activating serotonin receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • rhythmic process • entrainment of circadian clock • circadian rhythm • response to external stimulus • regulation of circadian rhythm • glutamate receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of protein modification process • regulation of catalytic activity • regulation of protein phosphorylation • negative regulation of biological process • negative regulation of phosphate metabolic process • negative regulation of catalytic activity • regulation of transferase activity • negative regulation of kinase activity • negative regulation of transferase activity • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • negative regulation of protein modification process • negative regulation of cellular process • protein metabolic process • phosphorus metabolic process • protein modification process • negative regulation of protein metabolic process • negative regulation of macromolecule metabolic process • protein phosphorylation • phosphorylation • regulation of protein metabolic process • negative regulation of metabolic process • negative regulation of molecular function • negative regulation of protein kinase activity • regulation of protein kinase activity • regulation of macromolecule metabolic process • regulation of molecular function • regulation of kinase activity • negative regulation of protein phosphorylation • macromolecule modification • negative regulation of phosphorus metabolic process • regulation of phosphorylation • regulation of phosphorus metabolic process • macromolecule metabolic process • negative regulation of phosphorylation • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • detection of abiotic stimulus • detection of stimulus • response to abiotic stimulus • response to radiation • phototransduction, visible light • cell activation • regulation of cell activation • regulation of platelet activation • regulation of multicellular organismal process • platelet activation • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway • G protein-coupled glutamate receptor signaling pathway • cellular response to nitrogen compound • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • nuclear membrane • organelle envelope • nuclear envelope • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor outer segment • photoreceptor cell cilium • cytosolic region • postsynapse • synapse • cell junction • postsynaptic cytosol • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • photoreceptor disc membrane • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • molecular transducer activity • cholecystokinin receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • cholecystokinin signaling pathway • head development • forebrain development • brain development • nervous system development • central nervous system development • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of biological quality • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • neuron migration • cellular developmental process • generation of neurons • neurogenesis • cell differentiation • cell migration • cell motility • axonogenesis • cell projection organization • plasma membrane bounded cell projection morphogenesis • cell development • neuron projection development • cell morphogenesis • cellular component organization • cell projection morphogenesis • neuron differentiation • neuron projection morphogenesis • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • axon development • cell morphogenesis involved in neuron differentiation • anatomical structure morphogenesis • neuron development • G-protein beta-subunit binding • fibroblast proliferation • molecular function activator activity • signaling receptor binding • signaling receptor activator activity • hormone activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • neuropeptide activity • neuropeptide hormone activity • peptide hormone receptor binding • hormone receptor binding • behavior • eating behavior • feeding behavior • digestion • axon
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	TYS
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	TYS
Name	O-SULFO-L-TYROSINE
Synonyms
Identifier
Formula	C9 H11 N O6 S
Molecular Weight	261.252
SMILES
PubChem	514186
Formal Charge	0
Total Atoms	28
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32238
Sequence	>7EZM_nogp_Chain_R E W Q P A V Q I L L Y S L I F L L S V L G N T L V I T V L I R N K R M R T V T N I F L L S L A V S D L M L C L F C M P F N L I P N L L K D F I F G S A V C K T T T Y F M G T S V S V S T F N L V A I S L E R Y G A I C K P L Q S R V W Q T K S H A L K V I A A T W C L S F T I M T P Y P I Y S N L V P F T K N N N Q T A N M C R F L L P N D V M Q Q S W H T F L L L I L F L I P G I V M M V A Y G L I S L E L Y Q G I K F E A S Q K K S N R I R S N S S A A N L M A K K R V I R M L I V I V V L F F L C W M P I F S A N A W R A Y D T A S A E R R L S G T P I S F I L L L S Y T S S C V N P I I Y C F M N K R F R L G F M A T F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9BKK	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.51	2024-05-22	To be published
	9BKK (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.51	2024-05-22	To be published
	9BKJ	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.59	2024-05-22	To be published
	9BKJ (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.59	2024-05-22	To be published
	7XOV	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	SR146131	-	Gs/β1/γ2	3	2022-07-20	10.1038/s41421-022-00420-3
	7XOV (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	SR146131	-		3	2022-07-20	10.1038/s41421-022-00420-3
	7XOU	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	Gs/β1/γ2	3.2	2022-07-20	10.1038/s41421-022-00420-3
	7XOU (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		3.2	2022-07-20	10.1038/s41421-022-00420-3
	7F8X	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	NN9056	-	-	3	2021-12-29	10.1038/s41589-021-00866-8
	7F8Y	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Devazepide	-	-	2.5	2021-10-13	10.1038/s41589-021-00866-8
	7F8U	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Lintitript	-	-	2.8	2021-10-13	10.1038/s41589-021-00866-8
	7EZK	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1-Gs)/β1/γ2	3.1	2021-08-25	10.1038/s41589-021-00841-3
	7EZK (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		3.1	2021-08-25	10.1038/s41589-021-00841-3
	7EZM	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGsL-Gq)/β1/γ2	2.9	2021-08-25	10.1038/s41589-021-00841-3
	7EZM (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.9	2021-08-25	10.1038/s41589-021-00841-3
	7EZH	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	Gi1/β1/γ2	3.2	2021-08-25	10.1038/s41589-021-00841-3
	7EZH (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		3.2	2021-08-25	10.1038/s41589-021-00841-3
	7MBY	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.44	2021-05-26	10.1371/journal.pbio.3001295
	7MBY (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.44	2021-05-26	10.1371/journal.pbio.3001295
	7MBX	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	Gs/β1/γ1	1.95	2021-05-26	10.1371/journal.pbio.3001295
	7MBX (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		1.95	2021-05-26	10.1371/journal.pbio.3001295

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