psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	L:L:D1	6.81	Yes	No	0	0	0
2	L:L:?2	L:L:M3	6.08	Yes	No	0	0	0
3	L:L:?2	R:R:K105	8.09	Yes	No	0	0	4
4	L:L:?2	R:R:F185	6.11	Yes	Yes	4	0	4
5	L:L:?2	R:R:M195	7.1	Yes	Yes	4	0	4
6	L:L:?2	R:R:R197	11.32	Yes	Yes	4	0	4
7	L:L:G4	L:L:W5	5.63	No	Yes	0	0	0
8	L:L:G4	R:R:R197	4.5	No	Yes	0	0	4
9	L:L:G4	R:R:E344	8.19	No	No	0	0	1
10	L:L:W5	R:R:R336	7	Yes	No	0	0	4
11	L:L:W5	R:R:L347	5.69	Yes	No	0	0	5
12	L:L:W5	R:R:S348	3.71	Yes	No	0	0	5
13	L:L:W5	R:R:I352	19.97	Yes	No	0	0	5
14	L:L:M6	R:R:N98	7.01	No	Yes	0	0	7
15	L:L:M6	R:R:C196	6.48	No	No	0	0	9
16	L:L:D7	R:R:Y176	10.34	Yes	Yes	1	0	7
17	L:L:D7	R:R:F198	4.78	Yes	Yes	1	0	5
18	L:L:D7	R:R:H210	7.56	Yes	Yes	1	0	6
19	L:L:D7	R:R:N333	4.04	Yes	No	1	0	7
20	L:L:F8	R:R:V125	5.24	No	No	0	0	7
21	L:L:F8	R:R:Y176	5.16	No	Yes	0	0	7
22	R:R:V43	R:R:W39	3.68	No	No	0	5	1
23	R:R:Q40	R:R:T350	4.25	No	No	0	1	3
24	R:R:L99	R:R:Q44	3.99	No	Yes	3	6	4
25	R:R:N102	R:R:Q44	6.6	No	Yes	0	6	4
26	R:R:L103	R:R:Q44	5.32	Yes	Yes	3	5	4
27	R:R:Q44	R:R:S353	10.11	Yes	No	0	4	5
28	R:R:I45	R:R:L103	4.28	No	Yes	0	5	5
29	R:R:M95	R:R:Y48	7.18	Yes	Yes	3	7	7
30	R:R:L99	R:R:Y48	18.76	No	Yes	3	6	7
31	R:R:L357	R:R:Y48	14.07	No	Yes	0	7	7
32	R:R:Y360	R:R:Y48	5.96	Yes	Yes	3	7	7
33	R:R:I51	R:R:M95	5.83	No	Yes	0	7	7
34	R:R:I51	R:R:T361	6.08	No	No	0	7	5
35	R:R:F52	R:R:V56	5.24	Yes	No	0	5	6
36	R:R:C91	R:R:F52	5.59	No	Yes	0	7	5
37	R:R:F52	R:R:M95	6.22	Yes	Yes	0	5	7
38	R:R:F52	R:R:P96	4.33	Yes	No	0	5	8
39	R:R:N59	R:R:S55	4.47	Yes	Yes	0	9	8
40	R:R:C91	R:R:S55	6.89	No	Yes	0	7	8
41	R:R:S363	R:R:S55	4.89	No	Yes	0	9	8
42	R:R:L88	R:R:V56	4.47	Yes	No	0	7	6
43	R:R:D87	R:R:N59	6.73	Yes	Yes	0	9	9
44	R:R:L88	R:R:N59	5.49	Yes	Yes	0	7	9
45	R:R:N59	R:R:P367	6.52	Yes	No	0	9	9
46	R:R:F372	R:R:L61	3.65	No	No	0	6	7
47	R:R:C371	R:R:V62	5.12	No	Yes	6	8	9
48	R:R:F372	R:R:V62	3.93	No	Yes	0	6	9
49	R:R:F377	R:R:V62	7.87	Yes	Yes	6	9	9
50	R:R:I63	R:R:L81	4.28	No	No	0	7	6
51	R:R:F377	R:R:V65	7.87	Yes	No	0	9	8
52	R:R:L66	R:R:N77	5.49	No	Yes	0	7	9
53	R:R:L66	R:R:L81	4.15	No	No	0	7	6
54	R:R:F377	R:R:L66	3.65	Yes	No	0	9	7
55	R:R:R68	R:R:T384	6.47	No	No	7	5	6
56	R:R:F385	R:R:R68	5.34	Yes	No	7	6	5
57	R:R:M72	R:R:N69	12.62	No	No	0	8	6
58	R:R:N69	R:R:T384	4.39	No	No	0	6	6
59	R:R:K70	R:R:R73	3.71	No	No	0	7	8
60	R:R:F377	R:R:M72	4.98	Yes	No	0	9	8
61	R:R:N77	R:R:T74	8.77	Yes	No	0	9	7
62	R:R:N77	R:R:T76	4.39	Yes	No	0	9	8
63	R:R:L80	R:R:N77	4.12	No	Yes	0	8	9
64	R:R:I78	R:R:K155	5.82	No	No	0	5	4
65	R:R:A158	R:R:I78	4.87	No	No	0	7	5
66	R:R:F79	R:R:I135	3.77	Yes	No	0	8	9
67	R:R:E138	R:R:F79	8.16	No	Yes	0	9	8
68	R:R:F79	R:R:V161	5.24	Yes	No	0	8	6
69	R:R:F79	R:R:I162	5.02	Yes	No	0	8	7
70	R:R:C371	R:R:L80	6.35	No	No	0	8	8
71	R:R:N131	R:R:S82	8.94	Yes	No	0	8	9
72	R:R:I162	R:R:S82	7.74	No	No	0	7	9
73	R:R:S82	R:R:W166	6.18	No	Yes	0	9	9
74	R:R:D87	R:R:L83	8.14	Yes	No	2	9	9
75	R:R:L83	R:R:N131	4.12	No	Yes	0	9	8
76	R:R:L83	R:R:N366	5.49	No	Yes	2	9	9
77	R:R:S86	R:R:V127	4.85	No	Yes	0	8	8
78	R:R:S128	R:R:S86	6.52	No	No	0	9	8
79	R:R:D87	R:R:S128	4.42	Yes	No	0	9	9
80	R:R:D87	R:R:S363	4.42	Yes	No	0	9	9
81	R:R:D87	R:R:N366	8.08	Yes	Yes	2	9	9
82	R:R:L88	R:R:L92	5.54	Yes	No	0	7	5
83	R:R:L90	R:R:S124	9.01	No	No	0	8	6
84	R:R:F120	R:R:F93	20.36	No	No	0	5	5
85	R:R:C94	R:R:M121	8.1	No	No	0	7	7
86	R:R:C94	R:R:Y360	14.79	No	Yes	0	7	7
87	R:R:M95	R:R:Y360	7.18	Yes	Yes	3	7	7
88	R:R:F109	R:R:F97	5.36	Yes	No	0	6	6
89	R:R:F97	R:R:T117	9.08	No	No	0	6	6
90	R:R:M121	R:R:N98	5.61	No	Yes	0	7	7
91	R:R:L356	R:R:N98	4.12	No	Yes	3	6	7
92	R:R:N98	R:R:Y360	9.3	Yes	Yes	3	7	7
93	R:R:L103	R:R:L99	6.92	Yes	No	3	5	6
94	R:R:F107	R:R:P101	7.22	Yes	No	0	8	5
95	R:R:D106	R:R:I108	4.2	No	No	0	4	4
96	R:R:A193	R:R:D106	6.18	No	No	0	3	4
97	R:R:F107	R:R:F109	11.79	Yes	Yes	0	8	6
98	R:R:C114	R:R:F107	4.19	No	Yes	5	9	8
99	R:R:F107	R:R:L182	4.87	Yes	No	0	8	5
100	R:R:C196	R:R:F107	11.17	No	Yes	5	9	8
101	R:R:F109	R:R:I108	10.05	Yes	No	0	6	4
102	R:R:F109	R:R:V113	6.55	Yes	No	0	6	5
103	R:R:C114	R:R:C196	7.28	No	No	5	9	9
104	R:R:K115	R:R:N181	5.6	No	No	0	5	5
105	R:R:T118	R:R:Y176	4.99	No	Yes	0	6	7
106	R:R:S180	R:R:T118	6.4	No	No	0	6	6
107	R:R:T123	R:R:Y119	4.99	No	No	8	6	6
108	R:R:F170	R:R:Y119	8.25	No	No	8	4	6
109	R:R:P177	R:R:Y119	12.52	No	No	0	6	6
110	R:R:G122	R:R:M173	5.24	No	No	0	6	8
111	R:R:F170	R:R:T123	11.67	No	No	8	4	6
112	R:R:V125	R:R:W326	7.36	No	Yes	0	7	8
113	R:R:F130	R:R:S126	5.28	No	No	0	6	7
114	R:R:S126	R:R:S169	6.52	No	No	0	7	8
115	R:R:N131	R:R:V127	4.43	Yes	Yes	0	8	8
116	R:R:V127	R:R:W166	17.16	Yes	Yes	0	8	9
117	R:R:S169	R:R:V127	4.85	No	Yes	0	8	8
118	R:R:F322	R:R:T129	3.89	No	No	0	9	8
119	R:R:F130	R:R:T165	5.19	No	No	0	6	7
120	R:R:N131	R:R:T165	4.39	Yes	No	0	8	7
121	R:R:L132	R:R:N366	5.49	No	Yes	0	8	9
122	R:R:I135	R:R:R139	3.76	No	Yes	2	9	9
123	R:R:I135	R:R:Y370	4.84	No	Yes	2	9	9
124	R:R:M225	R:R:S136	7.67	No	Yes	2	8	9
125	R:R:S136	R:R:Y229	6.36	Yes	Yes	2	9	9
126	R:R:E138	R:R:Q153	11.47	No	Yes	0	9	7
127	R:R:E138	R:R:H157	8.62	No	Yes	0	9	7
128	R:R:R139	R:R:Y229	8.23	Yes	Yes	2	9	9
129	R:R:M314	R:R:R139	3.72	No	Yes	0	9	9
130	R:R:R139	R:R:Y370	6.17	Yes	Yes	2	9	9
131	R:R:C144	R:R:Y140	6.72	No	No	0	7	8
132	R:R:L231	R:R:Y140	8.21	No	No	0	5	8
133	R:R:I143	R:R:I232	4.42	No	No	0	9	9
134	R:R:K145	R:R:Q148	5.42	No	No	0	6	5
135	R:R:S149	R:R:W152	3.71	No	Yes	9	8	5
136	R:R:Q153	R:R:S149	11.55	Yes	No	9	7	8
137	R:R:Q153	R:R:W152	12.05	Yes	Yes	9	7	5
138	R:R:H157	R:R:W152	8.46	Yes	Yes	0	7	5
139	R:R:K160	R:R:S156	6.12	No	No	0	4	5
140	R:R:H157	R:R:V161	5.54	Yes	No	0	7	6
141	R:R:F170	R:R:W166	5.01	No	Yes	0	4	9
142	R:R:M173	R:R:Y176	3.59	No	Yes	0	8	7
143	R:R:P175	R:R:W209	4.05	No	Yes	0	8	8
144	R:R:F198	R:R:Y176	12.38	Yes	Yes	1	5	7
145	R:R:W209	R:R:Y176	6.75	Yes	Yes	1	8	7
146	R:R:I178	R:R:Y179	10.88	No	No	0	5	5
147	R:R:L200	R:R:Y179	8.21	Yes	No	1	4	5
148	R:R:P201	R:R:Y179	5.56	No	No	1	5	5
149	R:R:L182	R:R:N194	9.61	No	No	0	5	3
150	R:R:M195	R:R:V183	4.56	Yes	No	4	4	3
151	R:R:R197	R:R:V183	3.92	Yes	No	4	4	3
152	R:R:N194	R:R:P184	4.89	No	No	0	3	1
153	R:R:A193	R:R:F185	5.55	No	Yes	0	3	4
154	R:R:F185	R:R:M195	6.22	Yes	Yes	4	4	4
155	R:R:K187	R:R:Q191	9.49	No	No	0	2	2
156	R:R:N189	R:R:Q191	7.92	No	No	0	4	2
157	R:R:M195	R:R:R197	13.65	Yes	Yes	4	4	4
158	R:R:F198	R:R:L200	6.09	Yes	Yes	1	5	4
159	R:R:F198	R:R:Q206	4.68	Yes	Yes	1	5	5
160	R:R:F198	R:R:W209	8.02	Yes	Yes	1	5	8
161	R:R:L200	R:R:P201	4.93	Yes	No	1	4	5
162	R:R:L200	R:R:Q206	6.65	Yes	Yes	1	4	5
163	R:R:M205	R:R:N202	7.01	No	No	0	4	5
164	R:R:D203	R:R:Q207	7.83	No	No	0	2	4
165	R:R:H210	R:R:Q206	8.65	Yes	Yes	1	6	5
166	R:R:Q207	R:R:Y338	10.15	No	No	0	4	5
167	R:R:L213	R:R:W209	14.81	No	Yes	0	7	8
168	R:R:H210	R:R:N333	7.65	Yes	No	1	6	7
169	R:R:A337	R:R:H210	4.39	No	Yes	0	6	6
170	R:R:T211	R:R:Y338	4.99	No	No	0	6	5
171	R:R:F212	R:R:I216	7.54	No	No	0	5	5
172	R:R:L214	R:R:L219	6.92	No	No	0	7	6
173	R:R:F330	R:R:L217	6.09	No	No	0	7	7
174	R:R:F218	R:R:L219	3.65	Yes	No	0	8	6
175	R:R:F218	R:R:F323	6.43	Yes	No	0	8	6
176	R:R:F218	R:R:M327	8.71	Yes	No	0	8	6
177	R:R:F218	R:R:F330	8.57	Yes	No	0	8	7
178	R:R:M225	R:R:Y229	3.59	No	Yes	2	8	9
179	R:R:F322	R:R:M225	8.71	No	No	0	9	8
180	R:R:F323	R:R:M226	3.73	No	No	0	6	6
181	R:R:L315	R:R:Y229	16.41	No	Yes	0	8	9
182	R:R:I318	R:R:Y229	4.84	No	Yes	0	9	9
183	R:R:V319	R:R:Y229	3.79	No	Yes	0	8	9
184	R:R:G230	R:R:S233	3.71	No	No	0	1	6
185	R:R:I232	R:R:L315	4.28	No	No	0	9	8
186	R:R:I312	R:R:L236	4.28	No	Yes	0	8	9
187	R:R:I240	R:R:L305	5.71	No	No	0	5	4
188	R:R:I240	R:R:K308	5.82	No	No	0	5	8
189	R:R:K308	R:R:N304	16.79	No	No	0	8	4
190	R:R:M306	R:R:R310	9.93	No	No	0	5	8
191	R:R:I318	R:R:Y370	10.88	No	Yes	0	9	9
192	R:R:F322	R:R:W326	7.02	No	Yes	0	9	8
193	R:R:C325	R:R:W326	3.92	No	Yes	0	8	8
194	R:R:F330	R:R:W326	6.01	No	Yes	0	7	8
195	R:R:S359	R:R:W326	7.41	No	Yes	0	7	8
196	R:R:S362	R:R:W326	8.65	No	Yes	0	9	8
197	R:R:I355	R:R:P328	6.77	No	No	0	6	9
198	R:R:I329	R:R:L356	4.28	No	No	0	7	6
199	R:R:I329	R:R:S359	4.64	No	No	0	7	7
200	R:R:D339	R:R:W335	4.47	No	Yes	0	4	5
201	R:R:A343	R:R:W335	9.08	No	Yes	0	4	5
202	R:R:R346	R:R:W335	4	No	Yes	0	4	5
203	R:R:L347	R:R:W335	5.69	No	Yes	0	5	5
204	R:R:E344	R:R:R336	10.47	No	No	0	1	4
205	R:R:D339	R:R:S342	8.83	No	No	0	4	4
206	R:R:E344	R:R:T340	5.64	No	No	0	1	2
207	R:R:R345	R:R:S342	3.95	No	No	0	5	4
208	R:R:L356	R:R:Y360	10.55	No	Yes	3	6	7
209	R:R:N366	R:R:Y370	4.65	Yes	Yes	2	9	9
210	R:R:I369	R:R:Y370	4.84	No	Yes	0	9	9
211	R:R:C371	R:R:F377	11.17	No	Yes	6	8	9
212	R:R:N374	R:R:R376	3.62	No	No	0	9	7
213	R:R:F377	R:R:N374	3.62	Yes	No	0	9	9
214	R:R:K375	R:R:R378	3.71	No	No	0	6	9
215	R:R:K375	R:R:L379	11.28	No	No	0	6	5
216	R:R:F381	R:R:M382	3.73	No	No	0	7	5
217	R:R:F385	R:R:T384	6.49	Yes	No	7	6	6
218	R:R:L80	R:R:Y370	3.52	No	Yes	0	8	9
219	R:R:P221	R:R:T129	3.5	No	No	0	9	8
220	R:R:P175	R:R:T174	3.5	No	No	0	8	4
221	R:R:E243	R:R:F242	3.5	No	No	0	5	4
222	R:R:P351	R:R:T350	3.5	No	No	0	4	3
223	R:R:A228	R:R:S136	3.42	No	Yes	0	6	9
224	R:R:A84	R:R:V62	3.39	No	Yes	0	9	9
225	R:R:I100	R:R:P101	3.39	No	No	0	5	5
226	R:R:I220	R:R:P221	3.39	No	No	0	6	9
227	R:R:M327	R:R:P328	3.35	No	No	0	6	9
228	R:R:S353	R:R:T350	3.2	No	No	0	5	3
229	R:R:C364	R:R:L54	3.17	No	No	0	7	5
230	R:R:C94	R:R:L90	3.17	No	No	0	7	8
231	R:R:I172	R:R:S126	3.1	No	No	0	6	7
232	R:R:I63	R:R:V85	3.07	No	No	0	7	6
233	R:R:M327	R:R:S331	3.07	No	No	0	6	6
234	R:R:K115	R:R:S111	3.06	No	No	0	5	4
235	R:R:K115	R:R:S180	3.06	No	No	0	5	6
236	R:R:K155	R:R:V75	3.04	No	No	0	4	7
237	R:R:A142	R:R:Q153	3.03	No	Yes	0	8	7
238	R:R:F372	R:R:G58	3.01	No	No	0	6	8
239	R:R:F212	R:R:W209	3.01	No	Yes	0	5	8
240	R:R:F323	R:R:G222	3.01	No	No	0	6	6
241	R:R:L47	R:R:V43	2.98	No	No	0	5	5
242	R:R:L236	R:R:V311	2.98	Yes	No	0	9	9
243	R:R:L321	R:R:V317	2.98	No	No	0	6	7
244	R:R:L88	R:R:T60	2.95	Yes	No	0	7	4
245	R:R:I312	R:R:I316	2.94	No	No	0	8	7
246	R:R:G141	R:R:Y140	2.9	No	No	0	6	8
247	R:R:I100	R:R:L104	2.85	No	No	0	5	4
248	R:R:I108	R:R:L104	2.85	No	No	0	4	4
249	R:R:I232	R:R:L236	2.85	No	Yes	0	9	9
250	R:R:L200	R:R:M205	2.83	Yes	No	0	4	4
251	R:R:K308	R:R:L236	2.82	No	Yes	0	8	9
252	R:R:K309	R:R:L305	2.82	No	No	0	6	4
253	R:R:G141	R:R:W152	2.81	No	Yes	0	6	5
254	R:R:L357	R:R:L47	2.77	No	No	0	7	5
255	R:R:A134	R:R:F79	2.77	No	Yes	0	8	8
256	R:R:A158	R:R:F79	2.77	No	Yes	0	7	8
257	R:R:F354	R:R:S353	2.64	No	No	0	4	5
258	R:R:F381	R:R:V65	2.62	No	No	0	7	8
259	R:R:D203	R:R:Q206	2.61	No	Yes	0	2	5
260	R:R:A42	R:R:W39	2.59	No	No	0	6	1
261	R:R:F385	R:R:T64	2.59	Yes	No	0	6	4
262	R:R:F120	R:R:M89	2.49	No	No	0	5	7
263	R:R:F185	R:R:K187	2.48	Yes	No	0	4	2
264	R:R:N69	R:R:R71	2.41	No	No	0	6	6
265	R:R:M89	R:R:W166	2.33	No	Yes	0	7	9
266	R:R:Q238	R:R:Y237	2.25	No	No	0	5	6
267	R:R:A383	R:R:G380	1.95	No	No	0	5	8
268	R:R:P221	R:R:V133	1.77	No	No	0	9	7
269	R:R:G349	R:R:I352	1.76	No	No	0	3	5
270	R:R:G380	R:R:M72	1.75	No	No	0	8	8
271	R:R:C364	R:R:S55	1.72	No	Yes	0	7	8
272	R:R:G58	R:R:L57	1.71	No	No	0	8	4
273	R:R:G110	R:R:L182	1.71	No	No	0	7	5
274	R:R:G380	R:R:L379	1.71	No	No	0	8	5
275	R:R:K145	R:R:P146	1.67	No	No	0	6	8
276	R:R:L103	R:R:P41	1.64	Yes	No	0	5	4
277	R:R:L358	R:R:P328	1.64	No	No	0	8	9
278	R:R:C364	R:R:I368	1.64	No	No	0	7	6
279	R:R:C144	R:R:K145	1.62	No	No	0	7	6
280	R:R:V133	R:R:V224	1.6	No	No	0	7	7
281	R:R:S156	R:R:T154	1.6	No	No	0	5	8
282	R:R:A332	R:R:L347	1.58	No	No	0	5	5
283	R:R:T116	R:R:T117	1.57	No	No	0	4	6
284	R:R:I312	R:R:S233	1.55	No	No	0	8	6
285	R:R:I223	R:R:V227	1.54	No	No	0	4	5
286	R:R:I316	R:R:V320	1.54	No	No	0	7	6
287	R:R:I369	R:R:V365	1.54	No	No	0	9	7
288	R:R:C144	R:R:E235	1.52	No	No	0	7	6
289	R:R:L46	R:R:S49	1.5	No	No	0	4	4
290	R:R:L50	R:R:S49	1.5	No	No	0	4	4
291	R:R:L137	R:R:S136	1.5	No	Yes	0	6	9
292	R:R:L231	R:R:V227	1.49	No	No	0	5	5
293	R:R:L321	R:R:V365	1.49	No	No	0	6	7
294	R:R:N202	R:R:V204	1.48	No	No	0	5	2
295	R:R:L215	R:R:T211	1.47	No	No	0	3	6
296	R:R:I369	R:R:M373	1.46	No	No	0	9	7
297	R:R:F385	R:R:P386	1.44	Yes	No	0	6	1
298	R:R:I78	R:R:L159	1.43	No	No	0	5	5
299	R:R:K187	R:R:N188	1.4	No	No	0	2	1
300	R:R:L53	R:R:L54	1.38	No	No	0	4	5
301	R:R:L53	R:R:L57	1.38	No	No	0	4	4
302	R:R:L321	R:R:L324	1.38	No	No	0	6	5
303	R:R:A341	R:R:R345	1.38	No	No	0	1	5
304	R:R:H157	R:R:T154	1.37	Yes	No	0	7	8
305	R:R:L234	R:R:Q238	1.33	No	No	0	4	5
306	R:R:R150	R:R:S149	1.32	No	No	0	6	8
307	R:R:E243	R:R:N304	1.31	No	No	0	5	4
308	R:R:I67	R:R:R73	1.25	No	No	0	3	8
309	R:R:K155	R:R:R73	1.24	No	No	0	4	8
310	R:R:L199	R:R:R197	1.21	No	Yes	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?2	7.585	6	4	0
2	L:L:W5	8.4	5	0	0
3	L:L:D7	6.68	4	1	0
4	R:R:Q44	6.505	4	3	4
5	R:R:Y48	11.4925	4	3	7
6	R:R:F52	5.345	4	0	5
7	R:R:S55	4.4925	4	0	8
8	R:R:N59	5.8025	4	0	9
9	R:R:V62	5.0775	4	6	9
10	R:R:N77	5.6925	4	0	9
11	R:R:F79	4.62167	6	0	8
12	R:R:D87	6.358	5	2	9
13	R:R:L88	4.6125	4	0	7
14	R:R:M95	6.6025	4	3	7
15	R:R:N98	6.51	4	3	7
16	R:R:L103	4.54	4	3	5
17	R:R:F107	7.848	5	5	8
18	R:R:F109	8.4375	4	0	6
19	R:R:V127	7.8225	4	0	8
20	R:R:N131	5.47	4	0	8
21	R:R:S136	4.7375	4	2	9
22	R:R:R139	5.47	4	2	9
23	R:R:W152	6.7575	4	9	5
24	R:R:Q153	9.525	4	9	7
25	R:R:H157	5.9975	4	0	7
26	R:R:W166	7.67	4	0	9
27	R:R:Y176	7.20167	6	1	7
28	R:R:F185	5.09	4	4	4
29	R:R:M195	7.8825	4	4	4
30	R:R:R197	6.92	5	4	4
31	R:R:F198	7.19	5	1	5
32	R:R:L200	5.742	5	1	4
33	R:R:Q206	5.6475	4	1	5
34	R:R:W209	7.328	5	1	8
35	R:R:H210	7.0625	4	1	6
36	R:R:F218	6.84	4	0	8
37	R:R:Y229	7.20333	6	2	9
38	R:R:L236	3.2325	4	0	9
39	R:R:W326	6.72833	6	0	8
40	R:R:W335	5.81	4	0	5
41	R:R:Y360	9.556	5	3	7
42	R:R:N366	5.9275	4	2	9
43	R:R:Y370	5.81667	6	2	9
44	R:R:F377	6.52667	6	6	9
45	R:R:F385	3.965	4	7	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	R:R:R197	29.7496	11.32	Yes	Yes	4	0	4
2	L:L:G4	R:R:R197	53.5367	4.5	No	Yes	0	0	4
3	L:L:G4	L:L:W5	41.7704	5.63	No	Yes	0	0	0
4	L:L:W5	R:R:L347	27.0872	5.69	Yes	No	0	0	5
5	L:L:?2	R:R:F185	35.4494	6.11	Yes	Yes	4	0	4
6	R:R:A193	R:R:F185	74.6696	5.55	No	Yes	0	3	4
7	R:R:A193	R:R:D106	75.994	6.18	No	No	0	3	4
8	R:R:D106	R:R:I108	77.3129	4.2	No	No	0	4	4
9	R:R:F109	R:R:I108	79.6443	10.05	Yes	No	0	6	4
10	R:R:F107	R:R:F109	86.0884	11.79	Yes	Yes	0	8	6
11	R:R:C196	R:R:F107	96.2676	11.17	No	Yes	5	9	8
12	L:L:M6	R:R:C196	98.8425	6.48	No	No	0	0	9
13	L:L:M6	R:R:N98	100	7.01	No	Yes	0	0	7
14	R:R:L356	R:R:N98	43.3685	4.12	No	Yes	3	6	7
15	R:R:I329	R:R:L356	51.8676	4.28	No	No	0	7	6
16	R:R:I329	R:R:S359	52.1002	4.64	No	No	0	7	7
17	R:R:S359	R:R:W326	52.4915	7.41	No	Yes	0	7	8
18	R:R:V125	R:R:W326	32.0673	7.36	No	Yes	0	7	8
19	L:L:F8	R:R:V125	31.2108	5.24	No	No	0	0	7
20	L:L:F8	R:R:Y176	30.3434	5.16	No	Yes	0	0	7
21	R:R:F198	R:R:Y176	13.6352	12.38	Yes	Yes	1	5	7
22	R:R:N98	R:R:Y360	58.4211	9.3	Yes	Yes	3	7	7
23	R:R:L99	R:R:Y48	18.7796	18.76	No	Yes	3	6	7
24	R:R:L99	R:R:Q44	11.9688	3.99	No	Yes	3	6	4
25	R:R:M95	R:R:Y360	62.9306	7.18	Yes	Yes	3	7	7
26	R:R:F52	R:R:M95	86.3538	6.22	Yes	Yes	0	5	7
27	R:R:F52	R:R:V56	29.4213	5.24	Yes	No	0	5	6
28	R:R:C91	R:R:F52	59.3104	5.59	No	Yes	0	7	5
29	R:R:L88	R:R:V56	29.5225	4.47	Yes	No	0	7	6
30	R:R:L88	R:R:N59	30.0315	5.49	Yes	Yes	0	7	9
31	R:R:C91	R:R:S55	59.9453	6.89	No	Yes	0	7	8
32	R:R:N59	R:R:S55	30.9974	4.47	Yes	Yes	0	9	8
33	R:R:S363	R:R:S55	30.5842	4.89	No	Yes	0	9	8
34	R:R:D87	R:R:N59	61.2505	6.73	Yes	Yes	0	9	9
35	R:R:D87	R:R:S363	31.1014	4.42	Yes	No	0	9	9
36	R:R:F322	R:R:W326	66.9695	7.02	No	Yes	0	9	8
37	R:R:F322	R:R:M225	68.3814	8.71	No	No	0	9	8
38	R:R:M225	R:R:Y229	67.3143	3.59	No	Yes	2	8	9
39	R:R:R139	R:R:Y229	50.6417	8.23	Yes	Yes	2	9	9
40	R:R:R139	R:R:Y370	22.9197	6.17	Yes	Yes	2	9	9
41	R:R:L80	R:R:Y370	63.2289	3.52	No	Yes	0	8	9
42	R:R:C371	R:R:L80	47.2678	6.35	No	No	0	8	8
43	R:R:I318	R:R:Y229	22.6296	4.84	No	Yes	0	9	9
44	R:R:I318	R:R:Y370	22.7665	10.88	No	Yes	0	9	9
45	R:R:D87	R:R:N366	56.0597	8.08	Yes	Yes	2	9	9
46	R:R:N366	R:R:Y370	63.4204	4.65	Yes	Yes	2	9	9
47	R:R:C371	R:R:F377	37.9833	11.17	No	Yes	6	8	9
48	R:R:L80	R:R:N77	14.1853	4.12	No	Yes	0	8	9
49	R:R:F377	R:R:M72	26.8901	4.98	Yes	No	0	9	8
50	R:R:M72	R:R:N69	14.593	12.62	No	No	0	8	6
51	R:R:N69	R:R:T384	10.4501	4.39	No	No	0	6	6
52	R:R:I135	R:R:R139	27.9163	3.76	No	Yes	2	9	9
53	R:R:F79	R:R:I135	51.4079	3.77	Yes	No	0	8	9
54	R:R:E138	R:R:F79	28.9971	8.16	No	Yes	0	9	8
55	R:R:F79	R:R:V161	14.9761	5.24	Yes	No	0	8	6
56	R:R:D87	R:R:L83	24.9856	8.14	Yes	No	2	9	9
57	R:R:L83	R:R:N131	31.4434	4.12	No	Yes	0	9	8
58	R:R:N131	R:R:S82	11.8402	8.94	Yes	No	0	8	9
59	R:R:S82	R:R:W166	12.9922	6.18	No	Yes	0	9	9
60	R:R:N131	R:R:V127	14.8803	4.43	Yes	Yes	0	8	8
61	R:R:V127	R:R:W166	16.232	17.16	Yes	Yes	0	8	9
62	R:R:D87	R:R:S128	13.8104	4.42	Yes	No	0	9	9
63	R:R:S128	R:R:S86	12.2288	6.52	No	No	0	9	8
64	R:R:S86	R:R:V127	11.126	4.85	No	Yes	0	8	8
65	R:R:M89	R:R:W166	10.3817	2.33	No	Yes	0	7	9
66	R:R:F170	R:R:W166	13.8323	5.01	No	Yes	0	4	9
67	R:R:E138	R:R:Q153	14.1251	11.47	No	Yes	0	9	7
68	R:R:E138	R:R:H157	14.0649	8.62	No	Yes	0	9	7
69	R:R:H157	R:R:V161	14.0895	5.54	Yes	No	0	7	6
70	R:R:Q153	R:R:W152	10.4146	12.05	Yes	Yes	9	7	5
71	R:R:G141	R:R:W152	28.4088	2.81	No	Yes	0	6	5
72	R:R:G141	R:R:Y140	25.5849	2.9	No	No	0	6	8
73	R:R:C144	R:R:Y140	14.2345	6.72	No	No	0	7	8
74	R:R:H157	R:R:W152	20.7771	8.46	Yes	Yes	0	7	5
75	R:R:L315	R:R:Y229	18.4129	16.41	No	Yes	0	8	9
76	R:R:I232	R:R:L315	17.3622	4.28	No	No	0	9	8
77	R:R:F330	R:R:W326	13.0332	6.01	No	Yes	0	7	8
78	R:R:F218	R:R:F330	11.085	8.57	Yes	No	0	8	7
79	R:R:I232	R:R:L236	15.2743	2.85	No	Yes	0	9	9
80	R:R:L347	R:R:W335	21.1055	5.69	No	Yes	0	5	5
81	R:R:D339	R:R:W335	12.0919	4.47	No	Yes	0	4	5
82	R:R:I369	R:R:Y370	12.6064	4.84	No	Yes	0	9	9
83	R:R:G380	R:R:M72	10.4501	1.75	No	No	0	8	8
84	R:R:F185	R:R:M195	32.5024	6.22	Yes	Yes	4	4	4
85	R:R:M195	R:R:R197	29.5964	13.65	Yes	Yes	4	4	4
86	R:R:M95	R:R:Y48	21.1629	7.18	Yes	Yes	3	7	7
87	R:R:I135	R:R:Y370	24.1319	4.84	No	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?2	R:R:K105	8.09	4	Yes	No	0	4	0	1
L:L:?2	R:R:F185	6.11	4	Yes	Yes	0	4	0	1
L:L:?2	R:R:M195	7.1	4	Yes	Yes	0	4	0	1
L:L:?2	R:R:R197	11.32	4	Yes	Yes	0	4	0	1
L:L:G4	R:R:R197	4.5	0	No	Yes	0	4	0	1
L:L:G4	R:R:E344	8.19	0	No	No	0	1	0	1
L:L:W5	R:R:R336	7	0	Yes	No	0	4	0	1
L:L:W5	R:R:L347	5.69	0	Yes	No	0	5	0	1
L:L:W5	R:R:S348	3.71	0	Yes	No	0	5	0	1
L:L:W5	R:R:I352	19.97	0	Yes	No	0	5	0	1
L:L:M6	R:R:N98	7.01	0	No	Yes	0	7	0	1
L:L:M6	R:R:C196	6.48	0	No	No	0	9	0	1
L:L:D7	R:R:Y176	10.34	1	Yes	Yes	0	7	0	1
L:L:D7	R:R:F198	4.78	1	Yes	Yes	0	5	0	1
L:L:D7	R:R:H210	7.56	1	Yes	Yes	0	6	0	1
L:L:D7	R:R:N333	4.04	1	Yes	No	0	7	0	1
L:L:F8	R:R:V125	5.24	0	No	No	0	7	0	1
L:L:F8	R:R:Y176	5.16	0	No	Yes	0	7	0	1
R:R:M121	R:R:N98	5.61	0	No	Yes	7	7	2	1
R:R:L356	R:R:N98	4.12	3	No	Yes	6	7	2	1
R:R:N98	R:R:Y360	9.3	3	Yes	Yes	7	7	1	2
R:R:C114	R:R:F107	4.19	5	No	Yes	9	8	2	2
R:R:C196	R:R:F107	11.17	5	No	Yes	9	8	1	2
R:R:C114	R:R:C196	7.28	5	No	No	9	9	2	1
R:R:T118	R:R:Y176	4.99	0	No	Yes	6	7	2	1
R:R:V125	R:R:W326	7.36	0	No	Yes	7	8	1	2
R:R:M173	R:R:Y176	3.59	0	No	Yes	8	7	2	1
R:R:F198	R:R:Y176	12.38	1	Yes	Yes	5	7	1	1
R:R:W209	R:R:Y176	6.75	1	Yes	Yes	8	7	2	1
R:R:M195	R:R:V183	4.56	4	Yes	No	4	3	1	2
R:R:R197	R:R:V183	3.92	4	Yes	No	4	3	1	2
R:R:A193	R:R:F185	5.55	0	No	Yes	3	4	2	1
R:R:F185	R:R:M195	6.22	4	Yes	Yes	4	4	1	1
R:R:M195	R:R:R197	13.65	4	Yes	Yes	4	4	1	1
R:R:F198	R:R:L200	6.09	1	Yes	Yes	5	4	1	2
R:R:F198	R:R:Q206	4.68	1	Yes	Yes	5	5	1	2
R:R:F198	R:R:W209	8.02	1	Yes	Yes	5	8	1	2
R:R:L200	R:R:Q206	6.65	1	Yes	Yes	4	5	2	2
R:R:H210	R:R:Q206	8.65	1	Yes	Yes	6	5	1	2
R:R:H210	R:R:N333	7.65	1	Yes	No	6	7	1	1
R:R:A337	R:R:H210	4.39	0	No	Yes	6	6	2	1
R:R:L347	R:R:W335	5.69	0	No	Yes	5	5	1	2
R:R:E344	R:R:R336	10.47	0	No	No	1	4	1	1
R:R:E344	R:R:T340	5.64	0	No	No	1	2	1	2
R:R:L356	R:R:Y360	10.55	3	No	Yes	6	7	2	2
R:R:F185	R:R:K187	2.48	4	Yes	No	4	2	1	2
R:R:G349	R:R:I352	1.76	0	No	No	3	5	2	1
R:R:A332	R:R:L347	1.58	0	No	No	5	5	2	1
R:R:L199	R:R:R197	1.21	0	No	Yes	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7MBX_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.59
Number of Linked Nodes	279
Number of Links	310
Number of Hubs	45
Number of Links mediated by Hubs	167
Number of Communities	9
Number of Nodes involved in Communities	47
Number of Links involved in Communities	58

Path Summary
Number Of Nodes in MetaPath	88
Number Of Links MetaPath	87
Number of Shortest Paths	85577
Length Of Smallest Path	3
Average Path Length	17.1858
Length of Longest Path	37
Minimum Path Strength	1.245
Average Path Strength	6.40603
Maximum Path Strength	16.415
Minimum Path Correlation	0.7
Average Path Correlation	0.927396
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	45.218
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.1476
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • cholecystokinin signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • developmental process • multicellular organismal process • head development • forebrain development • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • anatomical structure development • system development • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of biological quality • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • cell-cell signaling • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • phospholipase C-activating G protein-coupled receptor signaling pathway • neuron migration • cellular developmental process • generation of neurons • neurogenesis • cell differentiation • cell migration • cell motility • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • axonogenesis • cell projection organization • plasma membrane bounded cell projection morphogenesis • cell development • neuron projection development • cell morphogenesis • cellular component organization • cell projection morphogenesis • neuron differentiation • neuron projection morphogenesis • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • axon development • cell morphogenesis involved in neuron differentiation • anatomical structure morphogenesis • neuron development • cellular anatomical structure • membrane • intracellular anatomical structure • cytoplasm • cytosol • cell periphery • plasma membrane • membrane-bounded organelle • nucleus • membrane-enclosed lumen • intracellular membrane-bounded organelle • intracellular organelle lumen • intracellular organelle • nucleoplasm
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • intracellular anatomical structure • cytoplasm • cytosol • cell periphery • plasma membrane • membrane-bounded organelle • nucleus • membrane-enclosed lumen • intracellular membrane-bounded organelle • intracellular organelle lumen • intracellular organelle • nucleoplasm • organelle lumen • organelle • nuclear lumen • hormone activity • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • neuropeptide hormone activity • neuropeptide activity • peptide hormone receptor binding • protein binding • binding • signaling receptor binding • hormone receptor binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • cholecystokinin signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • developmental process • multicellular organismal process • neuron migration • cellular developmental process • nervous system development • generation of neurons • neurogenesis • multicellular organism development • cell differentiation • anatomical structure development • cell migration • cell motility • system development • behavior • eating behavior • feeding behavior • axonogenesis • cell projection organization • plasma membrane bounded cell projection morphogenesis • cell development • neuron projection development • cell morphogenesis • cellular component organization • cell projection morphogenesis • neuron differentiation • neuron projection morphogenesis • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • axon development • cell morphogenesis involved in neuron differentiation • anatomical structure morphogenesis • neuron development • digestion • extracellular region • axon • cell projection • neuron projection • plasma membrane bounded cell projection • extracellular space • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • dendrite • dendritic tree • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • cell body • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • neuromuscular process • regulation of system process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • response to pH • cellular response to pH • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	TYS
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	TYS
Name	O-SULFO-L-TYROSINE
Synonyms
Identifier
Formula	C9 H11 N O6 S
Molecular Weight	261.252
SMILES
PubChem	514186
Formal Charge	0
Total Atoms	28
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	L
Protein	Cholecystokinin-8
UniProt	P06307
Sequence	>7MBX_nogp_Chain_L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P32238
Sequence	>7MBX_nogp_Chain_R E W Q P A V Q I L L Y S L I F L L S V L G N T L V I T V L I R N K R M R T V T N I F L L S L A V S D L M L C L F C M P F N L I P N L L K D F I F G S A V C K T T T Y F M G T S V S V S T F N L V A I S L E R Y G A I C K P L Q S R V W Q T K S H A L K V I A A T W C L S F T I M T P Y P I Y S N L V P F T K N N N Q T A N M C R F L L P N D V M Q Q S W H T F L L L I L F L I P G I V M M V A Y G L I S L E L Y Q G I K F E S A A N L M A K K R V I R M L I V I V V L F F L C W M P I F S A N A W R A Y D T A S A E R R L S G T P I S F I L L L S Y T S S C V N P I I Y C F M N K R F R L G F M A T F P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7MBX	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	Gs/β1/γ1	1.95	2021-05-26	doi.org/10.1371/journal.pbio.3001295
	7MBX (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		1.95	2021-05-26	doi.org/10.1371/journal.pbio.3001295
	7MBY	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.44	2021-05-26	doi.org/10.1371/journal.pbio.3001295
	7MBY (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.44	2021-05-26	doi.org/10.1371/journal.pbio.3001295
	7EZH	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	Gi1/β1/γ2	3.2	2021-08-25	doi.org/10.1038/s41589-021-00841-3
	7EZH (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		3.2	2021-08-25	doi.org/10.1038/s41589-021-00841-3
	7EZK	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1-Gs)/β1/γ2	3.1	2021-08-25	doi.org/10.1038/s41589-021-00841-3
	7EZK (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		3.1	2021-08-25	doi.org/10.1038/s41589-021-00841-3
	7EZM	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGsL-Gq)/β1/γ2	2.9	2021-08-25	doi.org/10.1038/s41589-021-00841-3
	7EZM (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.9	2021-08-25	doi.org/10.1038/s41589-021-00841-3
	7F8U	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Lintitript	-	-	2.8	2021-10-13	doi.org/10.1038/s41589-021-00866-8
	7F8Y	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Devazepide	-	-	2.5	2021-10-13	doi.org/10.1038/s41589-021-00866-8
	7F8X	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	NN9056	-	-	3	2021-12-29	doi.org/10.1038/s41589-021-00866-8
	7XOU	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	Gs/β1/γ2	3.2	2022-07-20	doi.org/10.1038/s41421-022-00420-3
	7XOU (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		3.2	2022-07-20	doi.org/10.1038/s41421-022-00420-3
	7XOV	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	SR146131	-	Gs/β1/γ2	3	2022-07-20	doi.org/10.1038/s41421-022-00420-3
	7XOV (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	SR146131	-		3	2022-07-20	doi.org/10.1038/s41421-022-00420-3
	9BKJ	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.59	2024-05-22	doi.org/10.1371/journal.pbio.3002673
	9BKJ (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.59	2024-05-22	doi.org/10.1371/journal.pbio.3002673
	9BKK	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.51	2024-05-22	doi.org/10.1371/journal.pbio.3002673
	9BKK (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.51	2024-05-22	doi.org/10.1371/journal.pbio.3002673

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