psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	L:L:D1	6.81	Yes	No	0	0	0
2	L:L:?2	L:L:M3	6.08	Yes	No	0	0	0
3	L:L:?2	R:R:K105	8.09	Yes	No	0	0	4
4	L:L:?2	R:R:F185	6.11	Yes	Yes	4	0	4
5	L:L:?2	R:R:M195	7.1	Yes	Yes	4	0	4
6	L:L:?2	R:R:R197	11.32	Yes	Yes	4	0	4
7	L:L:G4	L:L:W5	5.63	No	Yes	0	0	0
8	L:L:G4	R:R:R197	4.5	No	Yes	0	0	4
9	L:L:G4	R:R:E344	8.19	No	No	0	0	1
10	L:L:W5	R:R:R336	7	Yes	No	0	0	4
11	L:L:W5	R:R:L347	5.69	Yes	No	0	0	5
12	L:L:W5	R:R:S348	3.71	Yes	No	0	0	5
13	L:L:W5	R:R:I352	19.97	Yes	No	0	0	5
14	L:L:M6	R:R:N98	7.01	No	Yes	0	0	7
15	L:L:M6	R:R:C196	6.48	No	No	0	0	9
16	L:L:D7	R:R:Y176	10.34	Yes	Yes	1	0	7
17	L:L:D7	R:R:F198	4.78	Yes	Yes	1	0	5
18	L:L:D7	R:R:H210	7.56	Yes	Yes	1	0	6
19	L:L:D7	R:R:N333	4.04	Yes	No	1	0	7
20	L:L:F8	R:R:V125	5.24	No	No	0	0	7
21	L:L:F8	R:R:Y176	5.16	No	Yes	0	0	7
22	R:R:V43	R:R:W39	3.68	No	No	0	5	1
23	R:R:Q40	R:R:T350	4.25	No	No	0	1	3
24	R:R:L99	R:R:Q44	3.99	No	Yes	3	6	4
25	R:R:N102	R:R:Q44	6.6	No	Yes	0	6	4
26	R:R:L103	R:R:Q44	5.32	Yes	Yes	3	5	4
27	R:R:Q44	R:R:S353	10.11	Yes	No	0	4	5
28	R:R:I45	R:R:L103	4.28	No	Yes	0	5	5
29	R:R:M95	R:R:Y48	7.18	Yes	Yes	3	7	7
30	R:R:L99	R:R:Y48	18.76	No	Yes	3	6	7
31	R:R:L357	R:R:Y48	14.07	No	Yes	0	7	7
32	R:R:Y360	R:R:Y48	5.96	Yes	Yes	3	7	7
33	R:R:I51	R:R:M95	5.83	No	Yes	0	7	7
34	R:R:I51	R:R:T361	6.08	No	No	0	7	5
35	R:R:F52	R:R:V56	5.24	Yes	No	0	5	6
36	R:R:C91	R:R:F52	5.59	No	Yes	0	7	5
37	R:R:F52	R:R:M95	6.22	Yes	Yes	0	5	7
38	R:R:F52	R:R:P96	4.33	Yes	No	0	5	8
39	R:R:N59	R:R:S55	4.47	Yes	Yes	0	9	8
40	R:R:C91	R:R:S55	6.89	No	Yes	0	7	8
41	R:R:S363	R:R:S55	4.89	No	Yes	0	9	8
42	R:R:L88	R:R:V56	4.47	Yes	No	0	7	6
43	R:R:D87	R:R:N59	6.73	Yes	Yes	0	9	9
44	R:R:L88	R:R:N59	5.49	Yes	Yes	0	7	9
45	R:R:N59	R:R:P367	6.52	Yes	No	0	9	9
46	R:R:F372	R:R:L61	3.65	No	No	0	6	7
47	R:R:C371	R:R:V62	5.12	No	Yes	6	8	9
48	R:R:F372	R:R:V62	3.93	No	Yes	0	6	9
49	R:R:F377	R:R:V62	7.87	Yes	Yes	6	9	9
50	R:R:I63	R:R:L81	4.28	No	No	0	7	6
51	R:R:F377	R:R:V65	7.87	Yes	No	0	9	8
52	R:R:L66	R:R:N77	5.49	No	Yes	0	7	9
53	R:R:L66	R:R:L81	4.15	No	No	0	7	6
54	R:R:F377	R:R:L66	3.65	Yes	No	0	9	7
55	R:R:R68	R:R:T384	6.47	No	No	7	5	6
56	R:R:F385	R:R:R68	5.34	Yes	No	7	6	5
57	R:R:M72	R:R:N69	12.62	No	No	0	8	6
58	R:R:N69	R:R:T384	4.39	No	No	0	6	6
59	R:R:K70	R:R:R73	3.71	No	No	0	7	8
60	R:R:F377	R:R:M72	4.98	Yes	No	0	9	8
61	R:R:N77	R:R:T74	8.77	Yes	No	0	9	7
62	R:R:N77	R:R:T76	4.39	Yes	No	0	9	8
63	R:R:L80	R:R:N77	4.12	No	Yes	0	8	9
64	R:R:I78	R:R:K155	5.82	No	No	0	5	4
65	R:R:A158	R:R:I78	4.87	No	No	0	7	5
66	R:R:F79	R:R:I135	3.77	Yes	No	0	8	9
67	R:R:E138	R:R:F79	8.16	No	Yes	0	9	8
68	R:R:F79	R:R:V161	5.24	Yes	No	0	8	6
69	R:R:F79	R:R:I162	5.02	Yes	No	0	8	7
70	R:R:C371	R:R:L80	6.35	No	No	0	8	8
71	R:R:N131	R:R:S82	8.94	Yes	No	0	8	9
72	R:R:I162	R:R:S82	7.74	No	No	0	7	9
73	R:R:S82	R:R:W166	6.18	No	Yes	0	9	9
74	R:R:D87	R:R:L83	8.14	Yes	No	2	9	9
75	R:R:L83	R:R:N131	4.12	No	Yes	0	9	8
76	R:R:L83	R:R:N366	5.49	No	Yes	2	9	9
77	R:R:S86	R:R:V127	4.85	No	Yes	0	8	8
78	R:R:S128	R:R:S86	6.52	No	No	0	9	8
79	R:R:D87	R:R:S128	4.42	Yes	No	0	9	9
80	R:R:D87	R:R:S363	4.42	Yes	No	0	9	9
81	R:R:D87	R:R:N366	8.08	Yes	Yes	2	9	9
82	R:R:L88	R:R:L92	5.54	Yes	No	0	7	5
83	R:R:L90	R:R:S124	9.01	No	No	0	8	6
84	R:R:F120	R:R:F93	20.36	No	No	0	5	5
85	R:R:C94	R:R:M121	8.1	No	No	0	7	7
86	R:R:C94	R:R:Y360	14.79	No	Yes	0	7	7
87	R:R:M95	R:R:Y360	7.18	Yes	Yes	3	7	7
88	R:R:F109	R:R:F97	5.36	Yes	No	0	6	6
89	R:R:F97	R:R:T117	9.08	No	No	0	6	6
90	R:R:M121	R:R:N98	5.61	No	Yes	0	7	7
91	R:R:L356	R:R:N98	4.12	No	Yes	3	6	7
92	R:R:N98	R:R:Y360	9.3	Yes	Yes	3	7	7
93	R:R:L103	R:R:L99	6.92	Yes	No	3	5	6
94	R:R:F107	R:R:P101	7.22	Yes	No	0	8	5
95	R:R:D106	R:R:I108	4.2	No	No	0	4	4
96	R:R:A193	R:R:D106	6.18	No	No	0	3	4
97	R:R:F107	R:R:F109	11.79	Yes	Yes	0	8	6
98	R:R:C114	R:R:F107	4.19	No	Yes	5	9	8
99	R:R:F107	R:R:L182	4.87	Yes	No	0	8	5
100	R:R:C196	R:R:F107	11.17	No	Yes	5	9	8
101	R:R:F109	R:R:I108	10.05	Yes	No	0	6	4
102	R:R:F109	R:R:V113	6.55	Yes	No	0	6	5
103	R:R:C114	R:R:C196	7.28	No	No	5	9	9
104	R:R:K115	R:R:N181	5.6	No	No	0	5	5
105	R:R:T118	R:R:Y176	4.99	No	Yes	0	6	7
106	R:R:S180	R:R:T118	6.4	No	No	0	6	6
107	R:R:T123	R:R:Y119	4.99	No	No	8	6	6
108	R:R:F170	R:R:Y119	8.25	No	No	8	4	6
109	R:R:P177	R:R:Y119	12.52	No	No	0	6	6
110	R:R:G122	R:R:M173	5.24	No	No	0	6	8
111	R:R:F170	R:R:T123	11.67	No	No	8	4	6
112	R:R:V125	R:R:W326	7.36	No	Yes	0	7	8
113	R:R:F130	R:R:S126	5.28	No	No	0	6	7
114	R:R:S126	R:R:S169	6.52	No	No	0	7	8
115	R:R:N131	R:R:V127	4.43	Yes	Yes	0	8	8
116	R:R:V127	R:R:W166	17.16	Yes	Yes	0	8	9
117	R:R:S169	R:R:V127	4.85	No	Yes	0	8	8
118	R:R:F322	R:R:T129	3.89	No	No	0	9	8
119	R:R:F130	R:R:T165	5.19	No	No	0	6	7
120	R:R:N131	R:R:T165	4.39	Yes	No	0	8	7
121	R:R:L132	R:R:N366	5.49	No	Yes	0	8	9
122	R:R:I135	R:R:R139	3.76	No	Yes	2	9	9
123	R:R:I135	R:R:Y370	4.84	No	Yes	2	9	9
124	R:R:M225	R:R:S136	7.67	No	Yes	2	8	9
125	R:R:S136	R:R:Y229	6.36	Yes	Yes	2	9	9
126	R:R:E138	R:R:Q153	11.47	No	Yes	0	9	7
127	R:R:E138	R:R:H157	8.62	No	Yes	0	9	7
128	R:R:R139	R:R:Y229	8.23	Yes	Yes	2	9	9
129	R:R:M314	R:R:R139	3.72	No	Yes	0	9	9
130	R:R:R139	R:R:Y370	6.17	Yes	Yes	2	9	9
131	R:R:C144	R:R:Y140	6.72	No	No	0	7	8
132	R:R:L231	R:R:Y140	8.21	No	No	0	5	8
133	R:R:I143	R:R:I232	4.42	No	No	0	9	9
134	R:R:K145	R:R:Q148	5.42	No	No	0	6	5
135	R:R:S149	R:R:W152	3.71	No	Yes	9	8	5
136	R:R:Q153	R:R:S149	11.55	Yes	No	9	7	8
137	R:R:Q153	R:R:W152	12.05	Yes	Yes	9	7	5
138	R:R:H157	R:R:W152	8.46	Yes	Yes	0	7	5
139	R:R:K160	R:R:S156	6.12	No	No	0	4	5
140	R:R:H157	R:R:V161	5.54	Yes	No	0	7	6
141	R:R:F170	R:R:W166	5.01	No	Yes	0	4	9
142	R:R:M173	R:R:Y176	3.59	No	Yes	0	8	7
143	R:R:P175	R:R:W209	4.05	No	Yes	0	8	8
144	R:R:F198	R:R:Y176	12.38	Yes	Yes	1	5	7
145	R:R:W209	R:R:Y176	6.75	Yes	Yes	1	8	7
146	R:R:I178	R:R:Y179	10.88	No	No	0	5	5
147	R:R:L200	R:R:Y179	8.21	Yes	No	1	4	5
148	R:R:P201	R:R:Y179	5.56	No	No	1	5	5
149	R:R:L182	R:R:N194	9.61	No	No	0	5	3
150	R:R:M195	R:R:V183	4.56	Yes	No	4	4	3
151	R:R:R197	R:R:V183	3.92	Yes	No	4	4	3
152	R:R:N194	R:R:P184	4.89	No	No	0	3	1
153	R:R:A193	R:R:F185	5.55	No	Yes	0	3	4
154	R:R:F185	R:R:M195	6.22	Yes	Yes	4	4	4
155	R:R:K187	R:R:Q191	9.49	No	No	0	2	2
156	R:R:N189	R:R:Q191	7.92	No	No	0	4	2
157	R:R:M195	R:R:R197	13.65	Yes	Yes	4	4	4
158	R:R:F198	R:R:L200	6.09	Yes	Yes	1	5	4
159	R:R:F198	R:R:Q206	4.68	Yes	Yes	1	5	5
160	R:R:F198	R:R:W209	8.02	Yes	Yes	1	5	8
161	R:R:L200	R:R:P201	4.93	Yes	No	1	4	5
162	R:R:L200	R:R:Q206	6.65	Yes	Yes	1	4	5
163	R:R:M205	R:R:N202	7.01	No	No	0	4	5
164	R:R:D203	R:R:Q207	7.83	No	No	0	2	4
165	R:R:H210	R:R:Q206	8.65	Yes	Yes	1	6	5
166	R:R:Q207	R:R:Y338	10.15	No	No	0	4	5
167	R:R:L213	R:R:W209	14.81	No	Yes	0	7	8
168	R:R:H210	R:R:N333	7.65	Yes	No	1	6	7
169	R:R:A337	R:R:H210	4.39	No	Yes	0	6	6
170	R:R:T211	R:R:Y338	4.99	No	No	0	6	5
171	R:R:F212	R:R:I216	7.54	No	No	0	5	5
172	R:R:L214	R:R:L219	6.92	No	No	0	7	6
173	R:R:F330	R:R:L217	6.09	No	No	0	7	7
174	R:R:F218	R:R:L219	3.65	Yes	No	0	8	6
175	R:R:F218	R:R:F323	6.43	Yes	No	0	8	6
176	R:R:F218	R:R:M327	8.71	Yes	No	0	8	6
177	R:R:F218	R:R:F330	8.57	Yes	No	0	8	7
178	R:R:M225	R:R:Y229	3.59	No	Yes	2	8	9
179	R:R:F322	R:R:M225	8.71	No	No	0	9	8
180	R:R:F323	R:R:M226	3.73	No	No	0	6	6
181	R:R:L315	R:R:Y229	16.41	No	Yes	0	8	9
182	R:R:I318	R:R:Y229	4.84	No	Yes	0	9	9
183	R:R:V319	R:R:Y229	3.79	No	Yes	0	8	9
184	R:R:G230	R:R:S233	3.71	No	No	0	1	6
185	R:R:I232	R:R:L315	4.28	No	No	0	9	8
186	R:R:I312	R:R:L236	4.28	No	Yes	0	8	9
187	R:R:I240	R:R:L305	5.71	No	No	0	5	4
188	R:R:I240	R:R:K308	5.82	No	No	0	5	8
189	R:R:K308	R:R:N304	16.79	No	No	0	8	4
190	R:R:M306	R:R:R310	9.93	No	No	0	5	8
191	R:R:I318	R:R:Y370	10.88	No	Yes	0	9	9
192	R:R:F322	R:R:W326	7.02	No	Yes	0	9	8
193	R:R:C325	R:R:W326	3.92	No	Yes	0	8	8
194	R:R:F330	R:R:W326	6.01	No	Yes	0	7	8
195	R:R:S359	R:R:W326	7.41	No	Yes	0	7	8
196	R:R:S362	R:R:W326	8.65	No	Yes	0	9	8
197	R:R:I355	R:R:P328	6.77	No	No	0	6	9
198	R:R:I329	R:R:L356	4.28	No	No	0	7	6
199	R:R:I329	R:R:S359	4.64	No	No	0	7	7
200	R:R:D339	R:R:W335	4.47	No	Yes	0	4	5
201	R:R:A343	R:R:W335	9.08	No	Yes	0	4	5
202	R:R:R346	R:R:W335	4	No	Yes	0	4	5
203	R:R:L347	R:R:W335	5.69	No	Yes	0	5	5
204	R:R:E344	R:R:R336	10.47	No	No	0	1	4
205	R:R:D339	R:R:S342	8.83	No	No	0	4	4
206	R:R:E344	R:R:T340	5.64	No	No	0	1	2
207	R:R:R345	R:R:S342	3.95	No	No	0	5	4
208	R:R:L356	R:R:Y360	10.55	No	Yes	3	6	7
209	R:R:N366	R:R:Y370	4.65	Yes	Yes	2	9	9
210	R:R:I369	R:R:Y370	4.84	No	Yes	0	9	9
211	R:R:C371	R:R:F377	11.17	No	Yes	6	8	9
212	R:R:N374	R:R:R376	3.62	No	No	0	9	7
213	R:R:F377	R:R:N374	3.62	Yes	No	0	9	9
214	R:R:K375	R:R:R378	3.71	No	No	0	6	9
215	R:R:K375	R:R:L379	11.28	No	No	0	6	5
216	R:R:F381	R:R:M382	3.73	No	No	0	7	5
217	R:R:F385	R:R:T384	6.49	Yes	No	7	6	6
218	R:R:L80	R:R:Y370	3.52	No	Yes	0	8	9
219	R:R:P221	R:R:T129	3.5	No	No	0	9	8
220	R:R:P175	R:R:T174	3.5	No	No	0	8	4
221	R:R:E243	R:R:F242	3.5	No	No	0	5	4
222	R:R:P351	R:R:T350	3.5	No	No	0	4	3
223	R:R:A228	R:R:S136	3.42	No	Yes	0	6	9
224	R:R:A84	R:R:V62	3.39	No	Yes	0	9	9
225	R:R:I100	R:R:P101	3.39	No	No	0	5	5
226	R:R:I220	R:R:P221	3.39	No	No	0	6	9
227	R:R:M327	R:R:P328	3.35	No	No	0	6	9
228	R:R:S353	R:R:T350	3.2	No	No	0	5	3
229	R:R:C364	R:R:L54	3.17	No	No	0	7	5
230	R:R:C94	R:R:L90	3.17	No	No	0	7	8
231	R:R:I172	R:R:S126	3.1	No	No	0	6	7
232	R:R:I63	R:R:V85	3.07	No	No	0	7	6
233	R:R:M327	R:R:S331	3.07	No	No	0	6	6
234	R:R:K115	R:R:S111	3.06	No	No	0	5	4
235	R:R:K115	R:R:S180	3.06	No	No	0	5	6
236	R:R:K155	R:R:V75	3.04	No	No	0	4	7
237	R:R:A142	R:R:Q153	3.03	No	Yes	0	8	7
238	R:R:F372	R:R:G58	3.01	No	No	0	6	8
239	R:R:F212	R:R:W209	3.01	No	Yes	0	5	8
240	R:R:F323	R:R:G222	3.01	No	No	0	6	6
241	R:R:L47	R:R:V43	2.98	No	No	0	5	5
242	R:R:L236	R:R:V311	2.98	Yes	No	0	9	9
243	R:R:L321	R:R:V317	2.98	No	No	0	6	7
244	R:R:L88	R:R:T60	2.95	Yes	No	0	7	4
245	R:R:I312	R:R:I316	2.94	No	No	0	8	7
246	R:R:G141	R:R:Y140	2.9	No	No	0	6	8
247	R:R:I100	R:R:L104	2.85	No	No	0	5	4
248	R:R:I108	R:R:L104	2.85	No	No	0	4	4
249	R:R:I232	R:R:L236	2.85	No	Yes	0	9	9
250	R:R:L200	R:R:M205	2.83	Yes	No	0	4	4
251	R:R:K308	R:R:L236	2.82	No	Yes	0	8	9
252	R:R:K309	R:R:L305	2.82	No	No	0	6	4
253	R:R:G141	R:R:W152	2.81	No	Yes	0	6	5
254	R:R:L357	R:R:L47	2.77	No	No	0	7	5
255	R:R:A134	R:R:F79	2.77	No	Yes	0	8	8
256	R:R:A158	R:R:F79	2.77	No	Yes	0	7	8
257	R:R:F354	R:R:S353	2.64	No	No	0	4	5
258	R:R:F381	R:R:V65	2.62	No	No	0	7	8
259	R:R:D203	R:R:Q206	2.61	No	Yes	0	2	5
260	R:R:A42	R:R:W39	2.59	No	No	0	6	1
261	R:R:F385	R:R:T64	2.59	Yes	No	0	6	4
262	R:R:F120	R:R:M89	2.49	No	No	0	5	7
263	R:R:F185	R:R:K187	2.48	Yes	No	0	4	2
264	R:R:N69	R:R:R71	2.41	No	No	0	6	6
265	R:R:M89	R:R:W166	2.33	No	Yes	0	7	9
266	R:R:Q238	R:R:Y237	2.25	No	No	0	5	6
267	R:R:A383	R:R:G380	1.95	No	No	0	5	8
268	R:R:P221	R:R:V133	1.77	No	No	0	9	7
269	R:R:G349	R:R:I352	1.76	No	No	0	3	5
270	R:R:G380	R:R:M72	1.75	No	No	0	8	8
271	R:R:C364	R:R:S55	1.72	No	Yes	0	7	8
272	R:R:G58	R:R:L57	1.71	No	No	0	8	4
273	R:R:G110	R:R:L182	1.71	No	No	0	7	5
274	R:R:G380	R:R:L379	1.71	No	No	0	8	5
275	R:R:K145	R:R:P146	1.67	No	No	0	6	8
276	R:R:L103	R:R:P41	1.64	Yes	No	0	5	4
277	R:R:L358	R:R:P328	1.64	No	No	0	8	9
278	R:R:C364	R:R:I368	1.64	No	No	0	7	6
279	R:R:C144	R:R:K145	1.62	No	No	0	7	6
280	R:R:V133	R:R:V224	1.6	No	No	0	7	7
281	R:R:S156	R:R:T154	1.6	No	No	0	5	8
282	R:R:A332	R:R:L347	1.58	No	No	0	5	5
283	R:R:T116	R:R:T117	1.57	No	No	0	4	6
284	R:R:I312	R:R:S233	1.55	No	No	0	8	6
285	R:R:I223	R:R:V227	1.54	No	No	0	4	5
286	R:R:I316	R:R:V320	1.54	No	No	0	7	6
287	R:R:I369	R:R:V365	1.54	No	No	0	9	7
288	R:R:C144	R:R:E235	1.52	No	No	0	7	6
289	R:R:L46	R:R:S49	1.5	No	No	0	4	4
290	R:R:L50	R:R:S49	1.5	No	No	0	4	4
291	R:R:L137	R:R:S136	1.5	No	Yes	0	6	9
292	R:R:L231	R:R:V227	1.49	No	No	0	5	5
293	R:R:L321	R:R:V365	1.49	No	No	0	6	7
294	R:R:N202	R:R:V204	1.48	No	No	0	5	2
295	R:R:L215	R:R:T211	1.47	No	No	0	3	6
296	R:R:I369	R:R:M373	1.46	No	No	0	9	7
297	R:R:F385	R:R:P386	1.44	Yes	No	0	6	1
298	R:R:I78	R:R:L159	1.43	No	No	0	5	5
299	R:R:K187	R:R:N188	1.4	No	No	0	2	1
300	R:R:L53	R:R:L54	1.38	No	No	0	4	5
301	R:R:L53	R:R:L57	1.38	No	No	0	4	4
302	R:R:L321	R:R:L324	1.38	No	No	0	6	5
303	R:R:A341	R:R:R345	1.38	No	No	0	1	5
304	R:R:H157	R:R:T154	1.37	Yes	No	0	7	8
305	R:R:L234	R:R:Q238	1.33	No	No	0	4	5
306	R:R:R150	R:R:S149	1.32	No	No	0	6	8
307	R:R:E243	R:R:N304	1.31	No	No	0	5	4
308	R:R:I67	R:R:R73	1.25	No	No	0	3	8
309	R:R:K155	R:R:R73	1.24	No	No	0	4	8
310	R:R:L199	R:R:R197	1.21	No	Yes	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?2	7.585	6	4	0
2	L:L:W5	8.4	5	0	0
3	L:L:D7	6.68	4	1	0
4	R:R:Q44	6.505	4	3	4
5	R:R:Y48	11.4925	4	3	7
6	R:R:F52	5.345	4	0	5
7	R:R:S55	4.4925	4	0	8
8	R:R:N59	5.8025	4	0	9
9	R:R:V62	5.0775	4	6	9
10	R:R:N77	5.6925	4	0	9
11	R:R:F79	4.62167	6	0	8
12	R:R:D87	6.358	5	2	9
13	R:R:L88	4.6125	4	0	7
14	R:R:M95	6.6025	4	3	7
15	R:R:N98	6.51	4	3	7
16	R:R:L103	4.54	4	3	5
17	R:R:F107	7.848	5	5	8
18	R:R:F109	8.4375	4	0	6
19	R:R:V127	7.8225	4	0	8
20	R:R:N131	5.47	4	0	8
21	R:R:S136	4.7375	4	2	9
22	R:R:R139	5.47	4	2	9
23	R:R:W152	6.7575	4	9	5
24	R:R:Q153	9.525	4	9	7
25	R:R:H157	5.9975	4	0	7
26	R:R:W166	7.67	4	0	9
27	R:R:Y176	7.20167	6	1	7
28	R:R:F185	5.09	4	4	4
29	R:R:M195	7.8825	4	4	4
30	R:R:R197	6.92	5	4	4
31	R:R:F198	7.19	5	1	5
32	R:R:L200	5.742	5	1	4
33	R:R:Q206	5.6475	4	1	5
34	R:R:W209	7.328	5	1	8
35	R:R:H210	7.0625	4	1	6
36	R:R:F218	6.84	4	0	8
37	R:R:Y229	7.20333	6	2	9
38	R:R:L236	3.2325	4	0	9
39	R:R:W326	6.72833	6	0	8
40	R:R:W335	5.81	4	0	5
41	R:R:Y360	9.556	5	3	7
42	R:R:N366	5.9275	4	2	9
43	R:R:Y370	5.81667	6	2	9
44	R:R:F377	6.52667	6	6	9
45	R:R:F385	3.965	4	7	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	R:R:R197	29.7496	11.32	Yes	Yes	4	0	4
2	L:L:G4	R:R:R197	53.5367	4.5	No	Yes	0	0	4
3	L:L:G4	L:L:W5	41.7704	5.63	No	Yes	0	0	0
4	L:L:W5	R:R:L347	27.0872	5.69	Yes	No	0	0	5
5	L:L:?2	R:R:F185	35.4494	6.11	Yes	Yes	4	0	4
6	R:R:A193	R:R:F185	74.6696	5.55	No	Yes	0	3	4
7	R:R:A193	R:R:D106	75.994	6.18	No	No	0	3	4
8	R:R:D106	R:R:I108	77.3129	4.2	No	No	0	4	4
9	R:R:F109	R:R:I108	79.6443	10.05	Yes	No	0	6	4
10	R:R:F107	R:R:F109	86.0884	11.79	Yes	Yes	0	8	6
11	R:R:C196	R:R:F107	96.2676	11.17	No	Yes	5	9	8
12	L:L:M6	R:R:C196	98.8425	6.48	No	No	0	0	9
13	L:L:M6	R:R:N98	100	7.01	No	Yes	0	0	7
14	R:R:L356	R:R:N98	43.3685	4.12	No	Yes	3	6	7
15	R:R:I329	R:R:L356	51.8676	4.28	No	No	0	7	6
16	R:R:I329	R:R:S359	52.1002	4.64	No	No	0	7	7
17	R:R:S359	R:R:W326	52.4915	7.41	No	Yes	0	7	8
18	R:R:V125	R:R:W326	32.0673	7.36	No	Yes	0	7	8
19	L:L:F8	R:R:V125	31.2108	5.24	No	No	0	0	7
20	L:L:F8	R:R:Y176	30.3434	5.16	No	Yes	0	0	7
21	R:R:F198	R:R:Y176	13.6352	12.38	Yes	Yes	1	5	7
22	R:R:N98	R:R:Y360	58.4211	9.3	Yes	Yes	3	7	7
23	R:R:L99	R:R:Y48	18.7796	18.76	No	Yes	3	6	7
24	R:R:L99	R:R:Q44	11.9688	3.99	No	Yes	3	6	4
25	R:R:M95	R:R:Y360	62.9306	7.18	Yes	Yes	3	7	7
26	R:R:F52	R:R:M95	86.3538	6.22	Yes	Yes	0	5	7
27	R:R:F52	R:R:V56	29.4213	5.24	Yes	No	0	5	6
28	R:R:C91	R:R:F52	59.3104	5.59	No	Yes	0	7	5
29	R:R:L88	R:R:V56	29.5225	4.47	Yes	No	0	7	6
30	R:R:L88	R:R:N59	30.0315	5.49	Yes	Yes	0	7	9
31	R:R:C91	R:R:S55	59.9453	6.89	No	Yes	0	7	8
32	R:R:N59	R:R:S55	30.9974	4.47	Yes	Yes	0	9	8
33	R:R:S363	R:R:S55	30.5842	4.89	No	Yes	0	9	8
34	R:R:D87	R:R:N59	61.2505	6.73	Yes	Yes	0	9	9
35	R:R:D87	R:R:S363	31.1014	4.42	Yes	No	0	9	9
36	R:R:F322	R:R:W326	66.9695	7.02	No	Yes	0	9	8
37	R:R:F322	R:R:M225	68.3814	8.71	No	No	0	9	8
38	R:R:M225	R:R:Y229	67.3143	3.59	No	Yes	2	8	9
39	R:R:R139	R:R:Y229	50.6417	8.23	Yes	Yes	2	9	9
40	R:R:R139	R:R:Y370	22.9197	6.17	Yes	Yes	2	9	9
41	R:R:L80	R:R:Y370	63.2289	3.52	No	Yes	0	8	9
42	R:R:C371	R:R:L80	47.2678	6.35	No	No	0	8	8
43	R:R:I318	R:R:Y229	22.6296	4.84	No	Yes	0	9	9
44	R:R:I318	R:R:Y370	22.7665	10.88	No	Yes	0	9	9
45	R:R:D87	R:R:N366	56.0597	8.08	Yes	Yes	2	9	9
46	R:R:N366	R:R:Y370	63.4204	4.65	Yes	Yes	2	9	9
47	R:R:C371	R:R:F377	37.9833	11.17	No	Yes	6	8	9
48	R:R:L80	R:R:N77	14.1853	4.12	No	Yes	0	8	9
49	R:R:F377	R:R:M72	26.8901	4.98	Yes	No	0	9	8
50	R:R:M72	R:R:N69	14.593	12.62	No	No	0	8	6
51	R:R:N69	R:R:T384	10.4501	4.39	No	No	0	6	6
52	R:R:I135	R:R:R139	27.9163	3.76	No	Yes	2	9	9
53	R:R:F79	R:R:I135	51.4079	3.77	Yes	No	0	8	9
54	R:R:E138	R:R:F79	28.9971	8.16	No	Yes	0	9	8
55	R:R:F79	R:R:V161	14.9761	5.24	Yes	No	0	8	6
56	R:R:D87	R:R:L83	24.9856	8.14	Yes	No	2	9	9
57	R:R:L83	R:R:N131	31.4434	4.12	No	Yes	0	9	8
58	R:R:N131	R:R:S82	11.8402	8.94	Yes	No	0	8	9
59	R:R:S82	R:R:W166	12.9922	6.18	No	Yes	0	9	9
60	R:R:N131	R:R:V127	14.8803	4.43	Yes	Yes	0	8	8
61	R:R:V127	R:R:W166	16.232	17.16	Yes	Yes	0	8	9
62	R:R:D87	R:R:S128	13.8104	4.42	Yes	No	0	9	9
63	R:R:S128	R:R:S86	12.2288	6.52	No	No	0	9	8
64	R:R:S86	R:R:V127	11.126	4.85	No	Yes	0	8	8
65	R:R:M89	R:R:W166	10.3817	2.33	No	Yes	0	7	9
66	R:R:F170	R:R:W166	13.8323	5.01	No	Yes	0	4	9
67	R:R:E138	R:R:Q153	14.1251	11.47	No	Yes	0	9	7
68	R:R:E138	R:R:H157	14.0649	8.62	No	Yes	0	9	7
69	R:R:H157	R:R:V161	14.0895	5.54	Yes	No	0	7	6
70	R:R:Q153	R:R:W152	10.4146	12.05	Yes	Yes	9	7	5
71	R:R:G141	R:R:W152	28.4088	2.81	No	Yes	0	6	5
72	R:R:G141	R:R:Y140	25.5849	2.9	No	No	0	6	8
73	R:R:C144	R:R:Y140	14.2345	6.72	No	No	0	7	8
74	R:R:H157	R:R:W152	20.7771	8.46	Yes	Yes	0	7	5
75	R:R:L315	R:R:Y229	18.4129	16.41	No	Yes	0	8	9
76	R:R:I232	R:R:L315	17.3622	4.28	No	No	0	9	8
77	R:R:F330	R:R:W326	13.0332	6.01	No	Yes	0	7	8
78	R:R:F218	R:R:F330	11.085	8.57	Yes	No	0	8	7
79	R:R:I232	R:R:L236	15.2743	2.85	No	Yes	0	9	9
80	R:R:L347	R:R:W335	21.1055	5.69	No	Yes	0	5	5
81	R:R:D339	R:R:W335	12.0919	4.47	No	Yes	0	4	5
82	R:R:I369	R:R:Y370	12.6064	4.84	No	Yes	0	9	9
83	R:R:G380	R:R:M72	10.4501	1.75	No	No	0	8	8
84	R:R:F185	R:R:M195	32.5024	6.22	Yes	Yes	4	4	4
85	R:R:M195	R:R:R197	29.5964	13.65	Yes	Yes	4	4	4
86	R:R:M95	R:R:Y48	21.1629	7.18	Yes	Yes	3	7	7
87	R:R:I135	R:R:Y370	24.1319	4.84	No	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?2	R:R:K105	8.09	4	Yes	No	0	4	0	1
L:L:?2	R:R:F185	6.11	4	Yes	Yes	0	4	0	1
L:L:?2	R:R:M195	7.1	4	Yes	Yes	0	4	0	1
L:L:?2	R:R:R197	11.32	4	Yes	Yes	0	4	0	1
L:L:G4	R:R:R197	4.5	0	No	Yes	0	4	0	1
L:L:G4	R:R:E344	8.19	0	No	No	0	1	0	1
L:L:W5	R:R:R336	7	0	Yes	No	0	4	0	1
L:L:W5	R:R:L347	5.69	0	Yes	No	0	5	0	1
L:L:W5	R:R:S348	3.71	0	Yes	No	0	5	0	1
L:L:W5	R:R:I352	19.97	0	Yes	No	0	5	0	1
L:L:M6	R:R:N98	7.01	0	No	Yes	0	7	0	1
L:L:M6	R:R:C196	6.48	0	No	No	0	9	0	1
L:L:D7	R:R:Y176	10.34	1	Yes	Yes	0	7	0	1
L:L:D7	R:R:F198	4.78	1	Yes	Yes	0	5	0	1
L:L:D7	R:R:H210	7.56	1	Yes	Yes	0	6	0	1
L:L:D7	R:R:N333	4.04	1	Yes	No	0	7	0	1
L:L:F8	R:R:V125	5.24	0	No	No	0	7	0	1
L:L:F8	R:R:Y176	5.16	0	No	Yes	0	7	0	1
R:R:M121	R:R:N98	5.61	0	No	Yes	7	7	2	1
R:R:L356	R:R:N98	4.12	3	No	Yes	6	7	2	1
R:R:N98	R:R:Y360	9.3	3	Yes	Yes	7	7	1	2
R:R:C114	R:R:F107	4.19	5	No	Yes	9	8	2	2
R:R:C196	R:R:F107	11.17	5	No	Yes	9	8	1	2
R:R:C114	R:R:C196	7.28	5	No	No	9	9	2	1
R:R:T118	R:R:Y176	4.99	0	No	Yes	6	7	2	1
R:R:V125	R:R:W326	7.36	0	No	Yes	7	8	1	2
R:R:M173	R:R:Y176	3.59	0	No	Yes	8	7	2	1
R:R:F198	R:R:Y176	12.38	1	Yes	Yes	5	7	1	1
R:R:W209	R:R:Y176	6.75	1	Yes	Yes	8	7	2	1
R:R:M195	R:R:V183	4.56	4	Yes	No	4	3	1	2
R:R:R197	R:R:V183	3.92	4	Yes	No	4	3	1	2
R:R:A193	R:R:F185	5.55	0	No	Yes	3	4	2	1
R:R:F185	R:R:M195	6.22	4	Yes	Yes	4	4	1	1
R:R:M195	R:R:R197	13.65	4	Yes	Yes	4	4	1	1
R:R:F198	R:R:L200	6.09	1	Yes	Yes	5	4	1	2
R:R:F198	R:R:Q206	4.68	1	Yes	Yes	5	5	1	2
R:R:F198	R:R:W209	8.02	1	Yes	Yes	5	8	1	2
R:R:L200	R:R:Q206	6.65	1	Yes	Yes	4	5	2	2
R:R:H210	R:R:Q206	8.65	1	Yes	Yes	6	5	1	2
R:R:H210	R:R:N333	7.65	1	Yes	No	6	7	1	1
R:R:A337	R:R:H210	4.39	0	No	Yes	6	6	2	1
R:R:L347	R:R:W335	5.69	0	No	Yes	5	5	1	2
R:R:E344	R:R:R336	10.47	0	No	No	1	4	1	1
R:R:E344	R:R:T340	5.64	0	No	No	1	2	1	2
R:R:L356	R:R:Y360	10.55	3	No	Yes	6	7	2	2
R:R:F185	R:R:K187	2.48	4	Yes	No	4	2	1	2
R:R:G349	R:R:I352	1.76	0	No	No	3	5	2	1
R:R:A332	R:R:L347	1.58	0	No	No	5	5	2	1
R:R:L199	R:R:R197	1.21	0	No	Yes	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7MBX_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.59
Number of Linked Nodes	279
Number of Links	310
Number of Hubs	45
Number of Links mediated by Hubs	167
Number of Communities	9
Number of Nodes involved in Communities	47
Number of Links involved in Communities	58

Path Summary
Number Of Nodes in MetaPath	88
Number Of Links MetaPath	87
Number of Shortest Paths	85577
Length Of Smallest Path	3
Average Path Length	17.1858
Length of Longest Path	37
Minimum Path Strength	1.245
Average Path Strength	6.40603
Maximum Path Strength	16.415
Minimum Path Correlation	0.7
Average Path Correlation	0.927471
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	45.1835
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.1476
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding • fibroblast proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • molecular transducer activity • molecular function activator activity • signaling receptor binding • signaling receptor activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • neuropeptide activity • neuropeptide hormone activity • peptide hormone receptor binding • hormone receptor binding • neuron migration • cellular developmental process • nervous system development • generation of neurons • neurogenesis • cell differentiation • cell migration • cell motility • behavior • eating behavior • feeding behavior • axonogenesis • cell projection organization • plasma membrane bounded cell projection morphogenesis • cell development • neuron projection development • cell morphogenesis • cellular component organization • cell projection morphogenesis • neuron differentiation • neuron projection morphogenesis • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • axon development • cell morphogenesis involved in neuron differentiation • anatomical structure morphogenesis • neuron development • digestion • axon • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • cholecystokinin receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • transmembrane signaling receptor activity • cholecystokinin signaling pathway • head development • forebrain development • brain development • central nervous system development • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • cell-cell signaling • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	TYS
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	TYS
Name	O-SULFO-L-TYROSINE
Synonyms
Identifier
Formula	C9 H11 N O6 S
Molecular Weight	261.252
SMILES
PubChem	514186
Formal Charge	0
Total Atoms	28
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32238
Sequence	>7MBX_nogp_Chain_R E W Q P A V Q I L L Y S L I F L L S V L G N T L V I T V L I R N K R M R T V T N I F L L S L A V S D L M L C L F C M P F N L I P N L L K D F I F G S A V C K T T T Y F M G T S V S V S T F N L V A I S L E R Y G A I C K P L Q S R V W Q T K S H A L K V I A A T W C L S F T I M T P Y P I Y S N L V P F T K N N N Q T A N M C R F L L P N D V M Q Q S W H T F L L L I L F L I P G I V M M V A Y G L I S L E L Y Q G I K F E S A A N L M A K K R V I R M L I V I V V L F F L C W M P I F S A N A W R A Y D T A S A E R R L S G T P I S F I L L L S Y T S S C V N P I I Y C F M N K R F R L G F M A T F P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9BKK	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.51	2024-05-22	To be published
	9BKK (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.51	2024-05-22	To be published
	9BKJ	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.59	2024-05-22	To be published
	9BKJ (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.59	2024-05-22	To be published
	7XOV	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	SR146131	-	Gs/β1/γ2	3	2022-07-20	10.1038/s41421-022-00420-3
	7XOV (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	SR146131	-		3	2022-07-20	10.1038/s41421-022-00420-3
	7XOU	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	Gs/β1/γ2	3.2	2022-07-20	10.1038/s41421-022-00420-3
	7XOU (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		3.2	2022-07-20	10.1038/s41421-022-00420-3
	7F8X	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	NN9056	-	-	3	2021-12-29	10.1038/s41589-021-00866-8
	7F8Y	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Devazepide	-	-	2.5	2021-10-13	10.1038/s41589-021-00866-8
	7F8U	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Lintitript	-	-	2.8	2021-10-13	10.1038/s41589-021-00866-8
	7EZK	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1-Gs)/β1/γ2	3.1	2021-08-25	10.1038/s41589-021-00841-3
	7EZK (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		3.1	2021-08-25	10.1038/s41589-021-00841-3
	7EZM	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGsL-Gq)/β1/γ2	2.9	2021-08-25	10.1038/s41589-021-00841-3
	7EZM (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.9	2021-08-25	10.1038/s41589-021-00841-3
	7EZH	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	Gi1/β1/γ2	3.2	2021-08-25	10.1038/s41589-021-00841-3
	7EZH (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		3.2	2021-08-25	10.1038/s41589-021-00841-3
	7MBY	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.44	2021-05-26	10.1371/journal.pbio.3001295
	7MBY (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.44	2021-05-26	10.1371/journal.pbio.3001295
	7MBX	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	Gs/β1/γ1	1.95	2021-05-26	10.1371/journal.pbio.3001295
	7MBX (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		1.95	2021-05-26	10.1371/journal.pbio.3001295

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7MBX_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.