psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	L:L:D1	5.84	Yes	No	0	0	0
2	L:L:?2	L:L:M3	6.08	Yes	No	0	0	0
3	L:L:?2	R:R:P101	4.71	Yes	No	0	0	5
4	L:L:?2	R:R:K105	7.08	Yes	No	0	0	4
5	L:L:?2	R:R:F185	6.11	Yes	No	1	0	4
6	L:L:?2	R:R:M195	5.07	Yes	Yes	1	0	4
7	L:L:?2	R:R:R197	16.55	Yes	Yes	1	0	4
8	L:L:M3	R:R:S348	6.13	No	No	0	0	5
9	L:L:G4	L:L:W5	4.22	No	Yes	1	0	0
10	L:L:G4	R:R:R197	6	No	Yes	1	0	4
11	L:L:G4	R:R:E344	4.91	No	Yes	1	0	1
12	L:L:W5	R:R:N333	4.52	Yes	No	0	0	7
13	L:L:W5	R:R:R336	12	Yes	No	1	0	4
14	L:L:W5	R:R:E344	4.36	Yes	Yes	1	0	1
15	L:L:W5	R:R:L347	6.83	Yes	No	0	0	5
16	L:L:W5	R:R:I352	25.84	Yes	No	1	0	5
17	L:L:M6	R:R:N98	5.61	No	No	2	0	7
18	L:L:M6	R:R:M121	5.78	No	Yes	2	0	7
19	L:L:D7	R:R:Y176	10.34	Yes	Yes	1	0	7
20	L:L:D7	R:R:F198	8.36	Yes	Yes	1	0	5
21	L:L:D7	R:R:H210	8.82	Yes	No	0	0	6
22	L:L:D7	R:R:R336	4.76	Yes	No	1	0	4
23	L:L:F8	R:R:V125	10.49	Yes	No	0	0	7
24	L:L:F8	R:R:Y176	4.13	Yes	Yes	1	0	7
25	L:L:F8	R:R:I329	6.28	Yes	Yes	1	0	7
26	L:L:F8	R:R:F330	5.36	Yes	Yes	1	0	7
27	R:R:E38	R:R:Q40	5.1	No	Yes	0	3	1
28	R:R:Q40	R:R:W39	18.62	Yes	No	0	1	1
29	R:R:V43	R:R:W39	4.9	No	No	0	5	1
30	R:R:Q40	R:R:T350	8.5	Yes	Yes	0	1	3
31	R:R:Q44	R:R:T350	5.67	No	Yes	0	4	3
32	R:R:Q44	R:R:S353	7.22	No	No	0	4	5
33	R:R:I45	R:R:L103	5.71	No	No	0	5	5
34	R:R:L99	R:R:Y48	21.1	No	No	0	6	7
35	R:R:S353	R:R:Y48	5.09	No	No	0	5	7
36	R:R:L357	R:R:Y48	15.24	No	No	0	7	7
37	R:R:L50	R:R:L54	4.15	No	No	0	4	5
38	R:R:I51	R:R:M95	4.37	No	Yes	0	7	7
39	R:R:I51	R:R:L357	5.71	No	No	0	7	7
40	R:R:I51	R:R:T361	4.56	No	No	0	7	5
41	R:R:F52	R:R:V56	6.55	Yes	No	0	5	6
42	R:R:C91	R:R:F52	5.59	No	Yes	3	7	5
43	R:R:F52	R:R:M95	4.98	Yes	Yes	3	5	7
44	R:R:F52	R:R:P96	4.33	Yes	No	0	5	8
45	R:R:N59	R:R:S55	4.47	Yes	Yes	0	9	8
46	R:R:C91	R:R:S55	6.89	No	Yes	0	7	8
47	R:R:S363	R:R:S55	4.89	No	Yes	0	9	8
48	R:R:L57	R:R:L61	6.92	No	No	0	4	7
49	R:R:D87	R:R:N59	4.04	Yes	Yes	0	9	9
50	R:R:L88	R:R:N59	5.49	No	Yes	0	7	9
51	R:R:N59	R:R:P367	8.15	Yes	No	0	9	9
52	R:R:F381	R:R:L61	4.87	No	No	0	7	7
53	R:R:C371	R:R:V62	6.83	No	No	4	8	9
54	R:R:F377	R:R:V62	9.18	Yes	No	4	9	9
55	R:R:I63	R:R:L81	4.28	No	No	0	7	6
56	R:R:F377	R:R:V65	7.87	Yes	Yes	0	9	8
57	R:R:F381	R:R:V65	3.93	No	Yes	0	7	8
58	R:R:L66	R:R:N77	4.12	No	No	0	7	9
59	R:R:L66	R:R:L81	5.54	No	No	0	7	6
60	R:R:F377	R:R:L66	3.65	Yes	No	0	9	7
61	R:R:M72	R:R:N77	4.21	No	No	0	8	9
62	R:R:I78	R:R:R73	11.27	No	No	0	5	8
63	R:R:K155	R:R:R73	4.95	No	No	0	4	8
64	R:R:N77	R:R:T74	11.7	No	No	0	9	7
65	R:R:L80	R:R:T76	4.42	No	No	0	8	8
66	R:R:A134	R:R:F79	4.16	No	Yes	0	8	8
67	R:R:E138	R:R:F79	22.15	No	Yes	0	9	8
68	R:R:A158	R:R:F79	4.16	No	Yes	0	7	8
69	R:R:F79	R:R:I162	5.02	Yes	No	0	8	7
70	R:R:L80	R:R:Y370	4.69	No	Yes	0	8	9
71	R:R:N131	R:R:S82	7.45	No	No	0	8	9
72	R:R:I162	R:R:S82	9.29	No	No	0	7	9
73	R:R:S82	R:R:W166	6.18	No	No	0	9	9
74	R:R:D87	R:R:L83	8.14	Yes	No	0	9	9
75	R:R:L83	R:R:N131	4.12	No	No	0	9	8
76	R:R:L132	R:R:L83	4.15	No	No	0	8	9
77	R:R:S86	R:R:V127	6.46	No	Yes	0	8	8
78	R:R:D87	R:R:S128	5.89	Yes	No	0	9	9
79	R:R:D87	R:R:S363	4.42	Yes	No	0	9	9
80	R:R:D87	R:R:N366	6.73	Yes	Yes	0	9	9
81	R:R:L88	R:R:L92	6.92	No	No	0	7	5
82	R:R:M89	R:R:S124	4.6	No	No	0	7	6
83	R:R:C94	R:R:L90	4.76	No	No	0	7	8
84	R:R:L90	R:R:S124	7.51	No	No	0	8	6
85	R:R:C91	R:R:M95	4.86	No	Yes	3	7	7
86	R:R:F120	R:R:F93	20.36	No	No	0	5	5
87	R:R:C94	R:R:M121	8.1	No	Yes	0	7	7
88	R:R:C94	R:R:Y360	12.1	No	Yes	0	7	7
89	R:R:M95	R:R:Y360	5.99	Yes	Yes	0	7	7
90	R:R:F97	R:R:P96	4.33	No	No	0	6	8
91	R:R:F109	R:R:F97	7.5	Yes	No	0	6	6
92	R:R:F97	R:R:T117	12.97	No	No	0	6	6
93	R:R:M121	R:R:N98	5.61	Yes	No	2	7	7
94	R:R:N98	R:R:Y360	6.98	No	Yes	0	7	7
95	R:R:L103	R:R:L99	8.3	No	No	0	5	6
96	R:R:F107	R:R:P101	4.33	Yes	No	0	8	5
97	R:R:D106	R:R:I108	4.2	No	No	0	4	4
98	R:R:A193	R:R:D106	4.63	No	No	0	3	4
99	R:R:F107	R:R:F109	9.65	Yes	Yes	5	8	6
100	R:R:F107	R:R:V113	3.93	Yes	No	5	8	5
101	R:R:F107	R:R:L182	6.09	Yes	Yes	0	8	5
102	R:R:C196	R:R:F107	6.98	No	Yes	0	9	8
103	R:R:F109	R:R:I108	11.3	Yes	No	0	6	4
104	R:R:F109	R:R:V113	9.18	Yes	No	5	6	5
105	R:R:L182	R:R:S111	4.5	Yes	No	0	5	4
106	R:R:C114	R:R:C196	7.28	No	No	0	9	9
107	R:R:K115	R:R:S180	4.59	No	No	0	5	6
108	R:R:M121	R:R:T117	4.52	Yes	No	0	7	6
109	R:R:M121	R:R:T118	4.52	Yes	No	0	7	6
110	R:R:T118	R:R:Y176	3.75	No	Yes	0	6	7
111	R:R:T123	R:R:Y119	7.49	No	No	6	6	6
112	R:R:F170	R:R:Y119	8.25	No	No	6	4	6
113	R:R:P177	R:R:Y119	9.74	No	No	0	6	6
114	R:R:F170	R:R:T123	10.38	No	No	6	4	6
115	R:R:L217	R:R:V125	4.47	No	No	0	7	7
116	R:R:V125	R:R:W326	4.9	No	Yes	0	7	8
117	R:R:F130	R:R:S126	5.28	No	No	0	6	7
118	R:R:S126	R:R:S169	4.89	No	No	0	7	8
119	R:R:N131	R:R:V127	4.43	No	Yes	0	8	8
120	R:R:V127	R:R:W166	20.84	Yes	No	0	8	9
121	R:R:L217	R:R:T129	4.42	No	No	0	7	8
122	R:R:F130	R:R:T165	5.19	No	No	0	6	7
123	R:R:L132	R:R:N366	5.49	No	Yes	0	8	9
124	R:R:I135	R:R:R139	3.76	No	Yes	0	9	9
125	R:R:L137	R:R:S136	4.5	No	No	0	6	9
126	R:R:S136	R:R:Y229	5.09	No	Yes	0	9	9
127	R:R:R139	R:R:Y229	5.14	Yes	Yes	0	9	9
128	R:R:M314	R:R:R139	6.2	No	Yes	0	9	9
129	R:R:R139	R:R:Y370	5.14	Yes	Yes	0	9	9
130	R:R:C144	R:R:Y140	10.75	No	Yes	0	7	8
131	R:R:L231	R:R:Y140	8.21	No	Yes	0	5	8
132	R:R:I143	R:R:I232	5.89	No	No	0	9	9
133	R:R:K155	R:R:T154	4.5	No	No	0	4	8
134	R:R:H157	R:R:T154	8.21	No	No	0	7	8
135	R:R:F170	R:R:W166	5.01	No	No	0	4	9
136	R:R:I172	R:R:M173	4.37	No	No	0	6	8
137	R:R:M173	R:R:Y176	5.99	No	Yes	0	8	7
138	R:R:P175	R:R:T174	5.25	No	No	0	8	4
139	R:R:P175	R:R:W209	12.16	No	Yes	0	8	8
140	R:R:F198	R:R:Y176	6.19	Yes	Yes	1	5	7
141	R:R:I178	R:R:Y179	12.09	No	No	0	5	5
142	R:R:L200	R:R:Y179	8.21	Yes	No	1	4	5
143	R:R:P201	R:R:Y179	6.95	No	No	1	5	5
144	R:R:N181	R:R:V183	4.43	No	No	0	5	3
145	R:R:L182	R:R:N194	9.61	Yes	No	0	5	3
146	R:R:A193	R:R:F185	5.55	No	No	0	3	4
147	R:R:F185	R:R:M195	12.44	No	Yes	1	4	4
148	R:R:M195	R:R:R197	16.13	Yes	Yes	1	4	4
149	R:R:F198	R:R:L200	6.09	Yes	Yes	1	5	4
150	R:R:F198	R:R:Q206	9.37	Yes	Yes	1	5	5
151	R:R:F198	R:R:W209	4.01	Yes	Yes	0	5	8
152	R:R:L200	R:R:P201	4.93	Yes	No	1	4	5
153	R:R:L200	R:R:M205	5.65	Yes	No	0	4	4
154	R:R:L200	R:R:Q206	6.65	Yes	Yes	1	4	5
155	R:R:N202	R:R:V204	10.35	No	No	0	5	2
156	R:R:D203	R:R:Q207	7.83	No	No	0	2	4
157	R:R:H210	R:R:Q206	12.36	No	Yes	0	6	5
158	R:R:Q207	R:R:Y338	6.76	No	No	0	4	5
159	R:R:F212	R:R:W209	5.01	No	Yes	0	5	8
160	R:R:L213	R:R:W209	13.67	No	Yes	0	7	8
161	R:R:A337	R:R:H210	5.85	No	No	0	6	6
162	R:R:T211	R:R:Y338	6.24	No	No	0	6	5
163	R:R:F212	R:R:I216	12.56	No	No	0	5	5
164	R:R:F218	R:R:L214	3.65	Yes	No	0	8	7
165	R:R:F330	R:R:L217	6.09	Yes	No	0	7	7
166	R:R:F218	R:R:L219	3.65	Yes	No	0	8	6
167	R:R:F218	R:R:F323	4.29	Yes	No	0	8	6
168	R:R:F218	R:R:M327	6.22	Yes	No	0	8	6
169	R:R:F218	R:R:F330	5.36	Yes	Yes	0	8	7
170	R:R:M225	R:R:Y229	5.99	No	Yes	0	8	9
171	R:R:F322	R:R:M225	11.2	No	No	0	9	8
172	R:R:F323	R:R:M226	6.22	No	No	0	6	6
173	R:R:L315	R:R:Y229	12.89	No	Yes	0	8	9
174	R:R:I318	R:R:Y229	4.84	No	Yes	0	9	9
175	R:R:V319	R:R:Y229	5.05	No	Yes	0	8	9
176	R:R:G230	R:R:S233	3.71	No	No	0	1	6
177	R:R:K308	R:R:L236	4.23	No	Yes	0	8	9
178	R:R:I312	R:R:L236	7.14	Yes	Yes	0	8	9
179	R:R:K241	R:R:Q238	4.07	No	No	0	5	5
180	R:R:I240	R:R:L305	4.28	Yes	No	0	5	4
181	R:R:F242	R:R:Q246	12.88	No	No	0	4	5
182	R:R:K308	R:R:N304	8.39	No	No	0	8	4
183	R:R:M306	R:R:R310	6.2	No	No	0	5	8
184	R:R:A307	R:R:R310	4.15	No	No	0	6	8
185	R:R:K309	R:R:R313	11.14	No	No	0	6	7
186	R:R:I318	R:R:I369	4.42	No	No	0	9	9
187	R:R:I318	R:R:Y370	9.67	No	Yes	0	9	9
188	R:R:F322	R:R:W326	13.03	No	Yes	0	9	8
189	R:R:C325	R:R:W326	5.22	No	Yes	1	8	8
190	R:R:C325	R:R:S362	6.89	No	No	1	8	9
191	R:R:F330	R:R:W326	6.01	Yes	Yes	1	7	8
192	R:R:S359	R:R:W326	3.71	No	Yes	0	7	8
193	R:R:S362	R:R:W326	8.65	No	Yes	1	9	8
194	R:R:I355	R:R:P328	5.08	No	No	0	6	9
195	R:R:F330	R:R:I329	3.77	Yes	Yes	1	7	7
196	R:R:I329	R:R:N333	4.25	Yes	No	0	7	7
197	R:R:I329	R:R:S359	6.19	Yes	No	0	7	7
198	R:R:D339	R:R:W335	6.7	No	Yes	7	4	5
199	R:R:S342	R:R:W335	9.88	No	Yes	7	4	5
200	R:R:A343	R:R:W335	10.37	No	Yes	0	4	5
201	R:R:L347	R:R:W335	4.56	No	Yes	0	5	5
202	R:R:E344	R:R:R336	5.82	Yes	No	1	1	4
203	R:R:D339	R:R:S342	4.42	No	No	7	4	4
204	R:R:E344	R:R:T340	5.64	Yes	No	0	1	2
205	R:R:F354	R:R:T350	3.89	No	Yes	0	4	3
206	R:R:L356	R:R:Y360	7.03	No	Yes	0	6	7
207	R:R:S359	R:R:Y360	10.17	No	Yes	0	7	7
208	R:R:N366	R:R:S362	5.96	Yes	No	0	9	9
209	R:R:N366	R:R:Y370	4.65	Yes	Yes	0	9	9
210	R:R:F372	R:R:I368	3.77	No	No	0	6	6
211	R:R:C371	R:R:F377	8.38	No	Yes	4	8	9
212	R:R:F372	R:R:F377	5.36	No	Yes	0	6	9
213	R:R:K375	R:R:R376	9.9	No	No	0	6	7
214	R:R:K375	R:R:L379	8.46	No	No	0	6	5
215	R:R:I240	R:R:Y237	3.63	Yes	No	0	5	6
216	R:R:P221	R:R:V133	3.53	No	No	0	9	7
217	R:R:P221	R:R:T129	3.5	No	No	0	9	8
218	R:R:P351	R:R:T350	3.5	No	Yes	0	4	3
219	R:R:G380	R:R:M72	3.49	No	No	0	8	8
220	R:R:G122	R:R:M173	3.49	No	No	0	6	8
221	R:R:C114	R:R:S180	3.44	No	No	0	9	6
222	R:R:A228	R:R:S136	3.42	No	No	0	6	9
223	R:R:A84	R:R:V62	3.39	No	No	0	9	9
224	R:R:I100	R:R:P101	3.39	No	No	0	5	5
225	R:R:I220	R:R:P221	3.39	No	No	0	6	9
226	R:R:A142	R:R:I143	3.25	No	No	0	8	9
227	R:R:S169	R:R:V127	3.23	No	Yes	0	8	8
228	R:R:S156	R:R:T154	3.2	No	No	0	5	8
229	R:R:T384	R:R:V65	3.17	No	Yes	0	6	8
230	R:R:P41	R:R:Q40	3.16	No	Yes	0	4	1
231	R:R:I312	R:R:S233	3.1	Yes	No	0	8	6
232	R:R:I63	R:R:V85	3.07	No	No	0	7	6
233	R:R:I369	R:R:V365	3.07	No	No	0	9	7
234	R:R:K155	R:R:V75	3.04	No	No	0	4	7
235	R:R:M195	R:R:V183	3.04	Yes	No	0	4	3
236	R:R:F372	R:R:G58	3.01	No	No	0	6	8
237	R:R:F323	R:R:G222	3.01	No	No	0	6	6
238	R:R:L47	R:R:V43	2.98	No	No	0	5	5
239	R:R:L137	R:R:V224	2.98	No	No	0	6	7
240	R:R:L236	R:R:V311	2.98	Yes	No	0	9	9
241	R:R:L321	R:R:V317	2.98	No	No	0	6	7
242	R:R:L321	R:R:V365	2.98	No	No	0	6	7
243	R:R:N69	R:R:V65	2.96	No	Yes	0	6	8
244	L:L:?2	R:R:N102	2.95	Yes	No	0	0	6
245	R:R:L88	R:R:T60	2.95	No	No	0	7	4
246	R:R:I63	R:R:I67	2.94	No	No	0	7	3
247	R:R:I352	R:R:I355	2.94	No	No	1	5	6
248	R:R:I223	R:R:M226	2.92	No	No	0	4	6
249	R:R:I368	R:R:M373	2.92	No	No	0	6	7
250	R:R:I369	R:R:M373	2.92	No	No	0	9	7
251	R:R:G141	R:R:Y140	2.9	No	Yes	0	6	8
252	R:R:Q153	R:R:S149	2.89	No	No	0	7	8
253	R:R:I108	R:R:L104	2.85	No	No	0	4	4
254	R:R:I172	R:R:L168	2.85	No	No	0	6	5
255	R:R:I220	R:R:L215	2.85	No	No	0	6	3
256	R:R:I232	R:R:L236	2.85	No	Yes	0	9	9
257	R:R:I232	R:R:L315	2.85	No	No	0	9	8
258	R:R:G141	R:R:W152	2.81	No	No	0	6	5
259	R:R:K145	R:R:Q148	2.71	No	No	0	6	5
260	R:R:E243	R:R:L305	2.65	No	No	0	5	4
261	R:R:F79	R:R:V75	2.62	Yes	No	0	8	7
262	R:R:F79	R:R:V161	2.62	Yes	No	0	8	6
263	R:R:D203	R:R:Q206	2.61	No	Yes	0	2	5
264	R:R:R68	R:R:T384	2.59	No	No	0	5	6
265	R:R:F120	R:R:T116	2.59	No	No	0	5	4
266	R:R:E138	R:R:Q153	2.55	No	No	0	9	7
267	R:R:F93	R:R:M89	2.49	No	No	0	5	7
268	R:R:M306	R:R:R313	2.48	No	No	0	5	7
269	R:R:M382	R:R:R378	2.48	No	No	0	5	9
270	R:R:G349	R:R:P351	2.03	No	No	0	3	4
271	R:R:R346	R:R:W335	2	No	Yes	0	4	5
272	R:R:A383	R:R:G380	1.95	No	No	0	5	8
273	R:R:G141	R:R:S149	1.86	No	No	0	6	8
274	R:R:P184	R:R:V183	1.77	No	No	0	1	3
275	R:R:C364	R:R:S55	1.72	No	Yes	0	7	8
276	R:R:G110	R:R:L182	1.71	No	Yes	0	7	5
277	R:R:A303	R:R:S301	1.71	No	No	0	4	4
278	R:R:K145	R:R:P146	1.67	No	No	0	6	8
279	R:R:L358	R:R:P328	1.64	No	No	0	8	9
280	R:R:A332	R:R:I352	1.62	No	No	1	5	5
281	R:R:A332	R:R:I355	1.62	No	No	1	5	6
282	R:R:C364	R:R:L54	1.59	No	No	0	7	5
283	R:R:T64	R:R:V65	1.59	No	Yes	0	4	8
284	R:R:A334	R:R:L214	1.58	No	No	0	6	7
285	R:R:I223	R:R:V227	1.54	No	No	0	4	5
286	R:R:I316	R:R:V320	1.54	No	No	0	7	6
287	R:R:M205	R:R:S208	1.53	No	No	0	4	4
288	R:R:F242	R:R:G239	1.51	No	No	0	4	7
289	R:R:N304	R:R:S301	1.49	No	No	0	4	4
290	R:R:I240	R:R:I312	1.47	Yes	Yes	0	5	8
291	R:R:I312	R:R:I316	1.47	Yes	No	0	8	7
292	R:R:N190	R:R:T186	1.46	No	No	0	4	3
293	R:R:I240	R:R:K309	1.45	Yes	No	0	5	6
294	R:R:K105	R:R:K187	1.44	No	No	0	4	2
295	R:R:I78	R:R:L159	1.43	No	No	0	5	5
296	R:R:M205	R:R:N202	1.4	No	No	0	4	5
297	R:R:L53	R:R:L54	1.38	No	No	0	4	5
298	R:R:L231	R:R:L234	1.38	No	No	0	5	4
299	R:R:L321	R:R:L324	1.38	No	No	0	6	5
300	R:R:E235	R:R:I143	1.37	No	No	0	6	9
301	R:R:L147	R:R:Q148	1.33	No	No	0	7	5
302	R:R:R150	R:R:S149	1.32	No	No	0	6	8
303	R:R:F385	R:R:T384	1.3	No	No	0	6	6
304	R:R:E243	R:R:Q246	1.27	No	No	0	5	5
305	R:R:M72	R:R:R71	1.24	No	No	0	8	6
306	R:R:F381	R:R:M382	1.24	No	No	0	7	5
307	R:R:L199	R:R:R197	1.21	No	Yes	0	4	4
308	R:R:F377	R:R:N374	1.21	Yes	No	0	9	9
309	R:R:K145	R:R:Y140	1.19	No	Yes	0	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?2	6.79875	8	1	0
2	L:L:W5	9.62833	6	1	0
3	L:L:D7	8.07	4	1	0
4	L:L:F8	6.565	4	1	0
5	R:R:Q40	8.845	4	0	1
6	R:R:F52	5.3625	4	3	5
7	R:R:S55	4.4925	4	0	8
8	R:R:N59	5.5375	4	0	9
9	R:R:V65	3.904	5	0	8
10	R:R:F79	6.78833	6	0	8
11	R:R:D87	5.844	5	0	9
12	R:R:M95	5.05	4	3	7
13	R:R:F107	6.196	5	5	8
14	R:R:F109	9.4075	4	5	6
15	R:R:M121	5.706	5	2	7
16	R:R:V127	8.74	4	0	8
17	R:R:R139	5.06	4	0	9
18	R:R:Y140	5.7625	4	0	8
19	R:R:Y176	6.08	5	1	7
20	R:R:L182	5.4775	4	0	5
21	R:R:M195	9.17	4	1	4
22	R:R:R197	9.9725	4	1	4
23	R:R:F198	6.804	5	1	5
24	R:R:L200	6.306	5	1	4
25	R:R:Q206	7.7475	4	1	5
26	R:R:W209	8.7125	4	0	8
27	R:R:F218	4.634	5	0	8
28	R:R:Y229	6.5	6	0	9
29	R:R:L236	4.3	4	0	9
30	R:R:I240	2.7075	4	0	5
31	R:R:I312	3.295	4	0	8
32	R:R:W326	6.92	6	1	8
33	R:R:I329	5.1225	4	1	7
34	R:R:F330	5.318	5	1	7
35	R:R:W335	6.702	5	7	5
36	R:R:E344	5.1825	4	1	1
37	R:R:T350	5.39	4	0	3
38	R:R:Y360	8.454	5	0	7
39	R:R:N366	5.7075	4	0	9
40	R:R:Y370	6.0375	4	0	9
41	R:R:F377	5.94167	6	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	R:R:R197	18.4621	16.55	Yes	Yes	1	0	4
2	L:L:G4	R:R:R197	31.9182	6	No	Yes	1	0	4
3	L:L:G4	L:L:W5	31.1174	4.22	No	Yes	1	0	0
4	L:L:W5	R:R:L347	11.1836	6.83	Yes	No	0	0	5
5	R:R:F107	R:R:F109	17.7787	9.65	Yes	Yes	5	8	6
6	R:R:F109	R:R:F97	24.9521	7.5	Yes	No	0	6	6
7	L:L:W5	R:R:N333	51.1657	4.52	Yes	No	0	0	7
8	R:R:I329	R:R:N333	52.6374	4.25	Yes	No	0	7	7
9	L:L:F8	R:R:V125	22.5496	10.49	Yes	No	0	0	7
10	R:R:F330	R:R:I329	28.616	3.77	Yes	Yes	1	7	7
11	R:R:F97	R:R:P96	19.2412	4.33	No	No	0	6	8
12	R:R:F52	R:R:P96	20.0142	4.33	Yes	No	0	5	8
13	R:R:I51	R:R:M95	31.0154	4.37	No	Yes	0	7	7
14	R:R:I51	R:R:L357	27.8554	5.71	No	No	0	7	7
15	R:R:L357	R:R:Y48	26.2662	15.24	No	No	0	7	7
16	R:R:S353	R:R:Y48	19.8473	5.09	No	No	0	5	7
17	R:R:Q44	R:R:S353	18.2271	7.22	No	No	0	4	5
18	R:R:Q44	R:R:T350	16.6007	5.67	No	Yes	0	4	3
19	R:R:Q40	R:R:T350	10.0334	8.5	Yes	Yes	0	1	3
20	R:R:C91	R:R:F52	16.5018	5.59	No	Yes	3	7	5
21	R:R:C91	R:R:S55	36.8066	6.89	No	Yes	0	7	8
22	R:R:N59	R:R:S55	20.3358	4.47	Yes	Yes	0	9	8
23	R:R:S363	R:R:S55	19.1114	4.89	No	Yes	0	9	8
24	R:R:F330	R:R:W326	59.7737	6.01	Yes	Yes	1	7	8
25	R:R:F322	R:R:W326	52.2293	13.03	No	Yes	0	9	8
26	R:R:F322	R:R:M225	51.3419	11.2	No	No	0	9	8
27	R:R:M225	R:R:Y229	51.1502	5.99	No	Yes	0	8	9
28	R:R:I318	R:R:Y229	39.5863	4.84	No	Yes	0	9	9
29	R:R:I318	R:R:I369	70.781	4.42	No	No	0	9	9
30	R:R:I369	R:R:M373	61.4742	2.92	No	No	0	9	7
31	R:R:I368	R:R:M373	59.5789	2.92	No	No	0	6	7
32	R:R:F372	R:R:I368	57.6773	3.77	No	No	0	6	6
33	R:R:F372	R:R:F377	53.8526	5.36	No	Yes	0	6	9
34	R:R:F377	R:R:V65	22.5465	7.87	Yes	Yes	0	9	8
35	R:R:F381	R:R:V65	10.3395	3.93	No	Yes	0	7	8
36	R:R:I329	R:R:S359	32.314	6.19	Yes	No	0	7	7
37	R:R:S359	R:R:W326	50.6679	3.71	No	Yes	0	7	8
38	R:R:S362	R:R:W326	80.3228	8.65	No	Yes	1	9	8
39	R:R:N366	R:R:S362	80.6258	5.96	Yes	No	0	9	9
40	R:R:N366	R:R:Y370	77.1535	4.65	Yes	Yes	0	9	9
41	R:R:I318	R:R:Y370	58.5245	9.67	No	Yes	0	9	9
42	R:R:D87	R:R:N59	23.3504	4.04	Yes	Yes	0	9	9
43	R:R:D87	R:R:S363	19.7143	4.42	Yes	No	0	9	9
44	R:R:D87	R:R:N366	63.3201	6.73	Yes	Yes	0	9	9
45	R:R:F377	R:R:L66	22.3858	3.65	Yes	No	0	9	7
46	R:R:L66	R:R:N77	12.3895	4.12	No	No	0	7	9
47	R:R:D87	R:R:L83	61.7927	8.14	Yes	No	0	9	9
48	R:R:L83	R:R:N131	100	4.12	No	No	0	9	8
49	R:R:N131	R:R:S82	73.907	7.45	No	No	0	8	9
50	R:R:I162	R:R:S82	61.5144	9.29	No	No	0	7	9
51	R:R:F79	R:R:I162	59.3099	5.02	Yes	No	0	8	7
52	R:R:F79	R:R:V75	18.7465	2.62	Yes	No	0	8	7
53	R:R:K155	R:R:V75	16.4245	3.04	No	No	0	4	7
54	R:R:L132	R:R:N366	41.7507	5.49	No	Yes	0	8	9
55	R:R:L132	R:R:L83	40.9189	4.15	No	No	0	8	9
56	R:R:E138	R:R:F79	32.3728	22.15	No	Yes	0	9	8
57	R:R:S82	R:R:W166	12.0957	6.18	No	No	0	9	9
58	R:R:N131	R:R:V127	25.0387	4.43	No	Yes	0	8	8
59	R:R:V127	R:R:W166	11.7556	20.84	Yes	No	0	8	9
60	R:R:S359	R:R:Y360	34.3331	10.17	No	Yes	0	7	7
61	R:R:T118	R:R:Y176	11.1589	3.75	No	Yes	0	6	7
62	R:R:F170	R:R:W166	18.2642	5.01	No	No	0	4	9
63	R:R:L217	R:R:T129	11.5917	4.42	No	No	0	7	8
64	R:R:R139	R:R:Y229	15.197	5.14	Yes	Yes	0	9	9
65	R:R:R139	R:R:Y370	16.6285	5.14	Yes	Yes	0	9	9
66	R:R:E138	R:R:Q153	30.2641	2.55	No	No	0	9	7
67	R:R:Q153	R:R:S149	27.9729	2.89	No	No	0	7	8
68	R:R:G141	R:R:S149	23.3721	1.86	No	No	0	6	8
69	R:R:G141	R:R:Y140	18.7465	2.9	No	Yes	0	6	8
70	R:R:L315	R:R:Y229	45.7022	12.89	No	Yes	0	8	9
71	R:R:I232	R:R:L315	44.1315	2.85	No	No	0	9	8
72	R:R:F198	R:R:W209	12.4111	4.01	Yes	Yes	0	5	8
73	R:R:F198	R:R:L200	16.4461	6.09	Yes	Yes	1	5	4
74	R:R:F198	R:R:Q206	10.2282	9.37	Yes	Yes	1	5	5
75	R:R:F218	R:R:F330	13.0233	5.36	Yes	Yes	0	8	7
76	R:R:I232	R:R:L236	37.8239	2.85	No	Yes	0	9	9
77	R:R:I312	R:R:L236	28.3439	7.14	Yes	Yes	0	8	9
78	R:R:I240	R:R:I312	20.1379	1.47	Yes	Yes	0	5	8
79	R:R:M95	R:R:Y360	29.2839	5.99	Yes	Yes	0	7	7
80	R:R:C94	R:R:Y360	15.2495	12.1	No	Yes	0	7	7
81	R:R:M195	R:R:R197	10.1571	16.13	Yes	Yes	1	4	4
82	R:R:C91	R:R:M95	20.0575	4.86	No	Yes	3	7	7
83	L:L:F8	R:R:Y176	47.9067	4.13	Yes	Yes	1	0	7
84	R:R:F198	R:R:Y176	36.9891	6.19	Yes	Yes	1	5	7
85	L:L:F8	R:R:F330	23.9317	5.36	Yes	Yes	1	0	7
86	R:R:V125	R:R:W326	27.3236	4.9	No	Yes	0	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?2	R:R:P101	4.71	1	Yes	No	0	5	0	1
L:L:?2	R:R:K105	7.08	1	Yes	No	0	4	0	1
L:L:?2	R:R:F185	6.11	1	Yes	No	0	4	0	1
L:L:?2	R:R:M195	5.07	1	Yes	Yes	0	4	0	1
L:L:?2	R:R:R197	16.55	1	Yes	Yes	0	4	0	1
L:L:M3	R:R:S348	6.13	0	No	No	0	5	0	1
L:L:G4	R:R:R197	6	1	No	Yes	0	4	0	1
L:L:G4	R:R:E344	4.91	1	No	Yes	0	1	0	1
L:L:W5	R:R:N333	4.52	1	Yes	No	0	7	0	1
L:L:W5	R:R:R336	12	1	Yes	No	0	4	0	1
L:L:W5	R:R:E344	4.36	1	Yes	Yes	0	1	0	1
L:L:W5	R:R:L347	6.83	1	Yes	No	0	5	0	1
L:L:W5	R:R:I352	25.84	1	Yes	No	0	5	0	1
L:L:M6	R:R:N98	5.61	2	No	No	0	7	0	1
L:L:M6	R:R:M121	5.78	2	No	Yes	0	7	0	1
L:L:D7	R:R:Y176	10.34	1	Yes	Yes	0	7	0	1
L:L:D7	R:R:F198	8.36	1	Yes	Yes	0	5	0	1
L:L:D7	R:R:H210	8.82	1	Yes	No	0	6	0	1
L:L:D7	R:R:R336	4.76	1	Yes	No	0	4	0	1
L:L:F8	R:R:V125	10.49	1	Yes	No	0	7	0	1
L:L:F8	R:R:Y176	4.13	1	Yes	Yes	0	7	0	1
L:L:F8	R:R:I329	6.28	1	Yes	Yes	0	7	0	1
L:L:F8	R:R:F330	5.36	1	Yes	Yes	0	7	0	1
R:R:C94	R:R:M121	8.1	0	No	Yes	7	7	2	1
R:R:C94	R:R:Y360	12.1	0	No	Yes	7	7	2	2
R:R:M121	R:R:N98	5.61	2	Yes	No	7	7	1	1
R:R:N98	R:R:Y360	6.98	2	No	Yes	7	7	1	2
R:R:F107	R:R:P101	4.33	5	Yes	No	8	5	2	1
R:R:M121	R:R:T117	4.52	2	Yes	No	7	6	1	2
R:R:M121	R:R:T118	4.52	2	Yes	No	7	6	1	2
R:R:T118	R:R:Y176	3.75	0	No	Yes	6	7	2	1
R:R:L217	R:R:V125	4.47	0	No	No	7	7	2	1
R:R:V125	R:R:W326	4.9	0	No	Yes	7	8	1	2
R:R:M173	R:R:Y176	5.99	0	No	Yes	8	7	2	1
R:R:F198	R:R:Y176	6.19	1	Yes	Yes	5	7	1	1
R:R:A193	R:R:F185	5.55	0	No	No	3	4	2	1
R:R:F185	R:R:M195	12.44	1	No	Yes	4	4	1	1
R:R:M195	R:R:R197	16.13	1	Yes	Yes	4	4	1	1
R:R:F198	R:R:L200	6.09	1	Yes	Yes	5	4	1	2
R:R:F198	R:R:Q206	9.37	1	Yes	Yes	5	5	1	2
R:R:F198	R:R:W209	4.01	1	Yes	Yes	5	8	1	2
R:R:L200	R:R:Q206	6.65	1	Yes	Yes	4	5	2	2
R:R:H210	R:R:Q206	12.36	0	No	Yes	6	5	1	2
R:R:A337	R:R:H210	5.85	0	No	No	6	6	2	1
R:R:F330	R:R:L217	6.09	1	Yes	No	7	7	1	2
R:R:F218	R:R:F330	5.36	0	Yes	Yes	8	7	2	1
R:R:F330	R:R:W326	6.01	1	Yes	Yes	7	8	1	2
R:R:S359	R:R:W326	3.71	0	No	Yes	7	8	2	2
R:R:F330	R:R:I329	3.77	1	Yes	Yes	7	7	1	1
R:R:I329	R:R:N333	4.25	1	Yes	No	7	7	1	1
R:R:I329	R:R:S359	6.19	1	Yes	No	7	7	1	2
R:R:L347	R:R:W335	4.56	0	No	Yes	5	5	1	2
R:R:E344	R:R:R336	5.82	1	Yes	No	1	4	1	1
R:R:E344	R:R:T340	5.64	1	Yes	No	1	2	1	2
R:R:S359	R:R:Y360	10.17	0	No	Yes	7	7	2	2
R:R:I100	R:R:P101	3.39	0	No	No	5	5	2	1
R:R:M195	R:R:V183	3.04	1	Yes	No	4	3	1	2
L:L:?2	R:R:N102	2.95	1	Yes	No	0	6	0	1
R:R:I352	R:R:I355	2.94	1	No	No	5	6	1	2
R:R:A332	R:R:I352	1.62	1	No	No	5	5	2	1
R:R:A332	R:R:I355	1.62	1	No	No	5	6	2	2
R:R:K105	R:R:K187	1.44	0	No	No	4	2	1	2
R:R:L199	R:R:R197	1.21	0	No	Yes	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7EZK_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.65
Number of Linked Nodes	281
Number of Links	309
Number of Hubs	41
Number of Links mediated by Hubs	158
Number of Communities	7
Number of Nodes involved in Communities	42
Number of Links involved in Communities	51

Path Summary
Number Of Nodes in MetaPath	87
Number Of Links MetaPath	86
Number of Shortest Paths	86748
Length Of Smallest Path	3
Average Path Length	14.7087
Length of Longest Path	28
Minimum Path Strength	1.43
Average Path Strength	6.14204
Maximum Path Strength	18.17
Minimum Path Correlation	0.7
Average Path Correlation	0.927358
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	48.5116
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.5633
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • D1 dopamine receptor binding • molecular function activator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase activator activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • establishment of protein localization • nitrogen compound transport • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • regulation of hormone secretion • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • molecular transducer activity • cholecystokinin receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • cholecystokinin signaling pathway • head development • forebrain development • brain development • nervous system development • central nervous system development • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of biological quality • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • neuron migration • cellular developmental process • generation of neurons • neurogenesis • cell differentiation • cell migration • cell motility • axonogenesis • cell projection organization • plasma membrane bounded cell projection morphogenesis • cell development • neuron projection development • cell morphogenesis • cellular component organization • cell projection morphogenesis • neuron differentiation • neuron projection morphogenesis • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • axon development • cell morphogenesis involved in neuron differentiation • anatomical structure morphogenesis • neuron development • G-protein beta-subunit binding • fibroblast proliferation • molecular function activator activity • signaling receptor binding • signaling receptor activator activity • hormone activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • neuropeptide activity • neuropeptide hormone activity • peptide hormone receptor binding • hormone receptor binding • behavior • eating behavior • feeding behavior • digestion • axon
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	TYS
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	TYS
Name	O-SULFO-L-TYROSINE
Synonyms
Identifier
Formula	C9 H11 N O6 S
Molecular Weight	261.252
SMILES
PubChem	514186
Formal Charge	0
Total Atoms	28
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32238
Sequence	>7EZK_nogp_Chain_R E W Q P A V Q I L L Y S L I F L L S V L G N T L V I T V L I R N K R M R T V T N I F L L S L A V S D L M L C L F C M P F N L I P N L L K D F I F G S A V C K T T T Y F M G T S V S V S T F N L V A I S L E R Y G A I C K P L Q S R V W Q T K S H A L K V I A A T W C L S F T I M T P Y P I Y S N L V P F T K N N N Q T A N M C R F L L P N D V M Q Q S W H T F L L L I L F L I P G I V M M V A Y G L I S L E L Y Q G I K F E A S Q S A A N L M A K K R V I R M L I V I V V L F F L C W M P I F S A N A W R A Y D T A S A E R R L S G T P I S F I L L L S Y T S S C V N P I I Y C F M N K R F R L G F M A T F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9BKK	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.51	2024-05-22	To be published
	9BKK (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.51	2024-05-22	To be published
	9BKJ	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.59	2024-05-22	To be published
	9BKJ (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.59	2024-05-22	To be published
	7XOV	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	SR146131	-	Gs/β1/γ2	3	2022-07-20	10.1038/s41421-022-00420-3
	7XOV (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	SR146131	-		3	2022-07-20	10.1038/s41421-022-00420-3
	7XOU	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	Gs/β1/γ2	3.2	2022-07-20	10.1038/s41421-022-00420-3
	7XOU (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		3.2	2022-07-20	10.1038/s41421-022-00420-3
	7F8X	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	NN9056	-	-	3	2021-12-29	10.1038/s41589-021-00866-8
	7F8Y	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Devazepide	-	-	2.5	2021-10-13	10.1038/s41589-021-00866-8
	7F8U	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Lintitript	-	-	2.8	2021-10-13	10.1038/s41589-021-00866-8
	7EZK	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1-Gs)/β1/γ2	3.1	2021-08-25	10.1038/s41589-021-00841-3
	7EZK (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		3.1	2021-08-25	10.1038/s41589-021-00841-3
	7EZM	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGsL-Gq)/β1/γ2	2.9	2021-08-25	10.1038/s41589-021-00841-3
	7EZM (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.9	2021-08-25	10.1038/s41589-021-00841-3
	7EZH	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	Gi1/β1/γ2	3.2	2021-08-25	10.1038/s41589-021-00841-3
	7EZH (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		3.2	2021-08-25	10.1038/s41589-021-00841-3
	7MBY	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.44	2021-05-26	10.1371/journal.pbio.3001295
	7MBY (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.44	2021-05-26	10.1371/journal.pbio.3001295
	7MBX	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	Gs/β1/γ1	1.95	2021-05-26	10.1371/journal.pbio.3001295
	7MBX (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		1.95	2021-05-26	10.1371/journal.pbio.3001295

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