psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	L:L:M6	5.07	Yes	No	1	0	0
2	L:L:?2	R:R:P101	9.42	Yes	No	0	0	5
3	L:L:?2	R:R:K105	4.04	Yes	No	0	0	4
4	L:L:?2	R:R:F185	7.86	Yes	No	1	0	4
5	L:L:?2	R:R:M195	8.11	Yes	No	1	0	4
6	L:L:?2	R:R:R197	14.81	Yes	No	1	0	4
7	L:L:M3	R:R:E344	6.77	No	Yes	0	0	1
8	L:L:M3	R:R:S348	4.6	No	No	0	0	5
9	L:L:G4	L:L:W5	4.22	No	Yes	0	0	0
10	L:L:G4	R:R:R197	4.5	No	No	0	0	4
11	L:L:G4	R:R:E344	6.55	No	Yes	0	0	1
12	L:L:W5	R:R:N333	5.65	Yes	No	0	0	7
13	L:L:W5	R:R:R336	24.99	Yes	Yes	0	0	4
14	L:L:W5	R:R:I352	24.66	Yes	No	0	0	5
15	L:L:?101	L:L:M6	3.5	Yes	No	1	0	0
16	L:L:M6	R:R:N98	4.21	No	Yes	1	0	7
17	L:L:D7	R:R:Y176	9.2	Yes	Yes	0	0	7
18	L:L:D7	R:R:H210	11.35	Yes	No	0	0	6
19	L:L:D7	R:R:N333	4.04	Yes	No	0	0	7
20	L:L:D7	R:R:R336	3.57	Yes	Yes	0	0	4
21	L:L:F8	R:R:Y176	6.19	No	Yes	0	0	7
22	L:L:F8	R:R:F330	5.36	No	Yes	0	0	7
23	L:L:?101	R:R:N98	10.2	Yes	Yes	1	0	7
24	L:L:?101	R:R:M121	3.5	Yes	No	1	0	7
25	L:L:?101	R:R:L356	10.28	Yes	Yes	1	0	6
26	R:R:Q44	R:R:Y48	6.76	Yes	Yes	3	4	7
27	R:R:L99	R:R:Q44	5.32	Yes	Yes	3	6	4
28	R:R:L103	R:R:Q44	5.32	No	Yes	3	5	4
29	R:R:Q44	R:R:S353	8.66	Yes	No	3	4	5
30	R:R:I45	R:R:L99	8.56	No	Yes	3	5	6
31	R:R:I45	R:R:L103	8.56	No	No	3	5	5
32	R:R:L357	R:R:L47	4.15	No	No	0	7	5
33	R:R:L99	R:R:Y48	11.72	Yes	Yes	3	6	7
34	R:R:S353	R:R:Y48	3.82	No	Yes	3	5	7
35	R:R:L357	R:R:Y48	11.72	No	Yes	0	7	7
36	R:R:I51	R:R:L357	7.14	Yes	No	0	7	7
37	R:R:F52	R:R:V56	3.93	Yes	No	0	5	6
38	R:R:C91	R:R:F52	5.59	No	Yes	0	7	5
39	R:R:F52	R:R:M95	6.22	Yes	No	0	5	7
40	R:R:F52	R:R:P96	4.33	Yes	No	0	5	8
41	R:R:C364	R:R:L54	4.76	No	No	0	7	5
42	R:R:N59	R:R:S55	4.47	Yes	No	0	9	8
43	R:R:C91	R:R:S55	5.16	No	No	0	7	8
44	R:R:S363	R:R:S55	4.89	No	No	0	9	8
45	R:R:G58	R:R:L57	5.13	No	No	0	8	4
46	R:R:D87	R:R:N59	6.73	Yes	Yes	0	9	9
47	R:R:N59	R:R:P367	6.52	Yes	No	0	9	9
48	R:R:F381	R:R:L61	3.65	No	No	0	7	7
49	R:R:C371	R:R:V62	5.12	No	Yes	7	8	9
50	R:R:F377	R:R:V62	3.93	Yes	Yes	7	9	9
51	R:R:I63	R:R:L81	4.28	No	No	0	7	6
52	R:R:F385	R:R:T64	3.89	Yes	No	0	6	4
53	R:R:N69	R:R:V65	4.43	No	No	0	6	8
54	R:R:F377	R:R:V65	9.18	Yes	No	0	9	8
55	R:R:L66	R:R:L81	4.15	No	No	0	7	6
56	R:R:R68	R:R:T384	3.88	No	No	0	5	6
57	R:R:M72	R:R:N69	11.22	No	No	0	8	6
58	R:R:N69	R:R:T384	4.39	No	No	0	6	6
59	R:R:G380	R:R:M72	3.49	No	No	0	8	8
60	R:R:I78	R:R:R73	3.76	No	No	0	5	8
61	R:R:N77	R:R:T74	10.24	No	No	0	9	7
62	R:R:E138	R:R:V75	4.28	Yes	No	0	9	7
63	R:R:A134	R:R:F79	4.16	No	Yes	0	8	8
64	R:R:F79	R:R:I135	3.77	Yes	No	0	8	9
65	R:R:E138	R:R:F79	8.16	Yes	Yes	0	9	8
66	R:R:F79	R:R:V161	5.24	Yes	No	0	8	6
67	R:R:L80	R:R:Y370	3.52	No	Yes	0	8	9
68	R:R:N131	R:R:S82	8.94	No	No	0	8	9
69	R:R:I162	R:R:S82	6.19	No	No	4	7	9
70	R:R:S82	R:R:W166	4.94	No	Yes	4	9	9
71	R:R:D87	R:R:L83	9.5	Yes	No	2	9	9
72	R:R:L132	R:R:L83	4.15	No	No	2	8	9
73	R:R:L83	R:R:N366	8.24	No	Yes	2	9	9
74	R:R:S86	R:R:V127	4.85	No	No	0	8	8
75	R:R:S128	R:R:S86	4.89	No	No	0	9	8
76	R:R:D87	R:R:S363	5.89	Yes	No	0	9	9
77	R:R:D87	R:R:N366	6.73	Yes	Yes	2	9	9
78	R:R:L88	R:R:L92	4.15	No	No	0	7	5
79	R:R:F93	R:R:M89	3.73	No	No	0	5	7
80	R:R:M89	R:R:S124	4.6	No	No	0	7	6
81	R:R:M89	R:R:W166	4.65	No	Yes	0	7	9
82	R:R:C94	R:R:L90	6.35	No	No	0	7	8
83	R:R:L90	R:R:S124	9.01	No	No	0	8	6
84	R:R:F120	R:R:F93	20.36	No	No	0	5	5
85	R:R:C94	R:R:M121	8.1	No	No	0	7	7
86	R:R:C94	R:R:Y360	6.72	No	Yes	0	7	7
87	R:R:M95	R:R:Y360	10.78	No	Yes	0	7	7
88	R:R:F109	R:R:F97	7.5	Yes	No	0	6	6
89	R:R:F97	R:R:T117	9.08	No	No	0	6	6
90	R:R:M121	R:R:N98	4.21	No	Yes	1	7	7
91	R:R:L356	R:R:N98	4.12	Yes	Yes	1	6	7
92	R:R:N98	R:R:Y360	9.3	Yes	Yes	1	7	7
93	R:R:L103	R:R:L99	8.3	No	Yes	3	5	6
94	R:R:I100	R:R:P101	6.77	No	No	0	5	5
95	R:R:D106	R:R:L104	4.07	No	No	0	4	4
96	R:R:D106	R:R:I108	5.6	No	No	0	4	4
97	R:R:F107	R:R:F109	10.72	Yes	Yes	0	8	6
98	R:R:C114	R:R:F107	4.19	No	Yes	8	9	8
99	R:R:F107	R:R:L182	6.09	Yes	No	0	8	5
100	R:R:C196	R:R:F107	11.17	No	Yes	8	9	8
101	R:R:F109	R:R:I108	7.54	Yes	No	0	6	4
102	R:R:F109	R:R:V113	7.87	Yes	No	0	6	5
103	R:R:K115	R:R:S111	4.59	No	No	0	5	4
104	R:R:C114	R:R:S180	5.16	No	No	0	9	6
105	R:R:C114	R:R:C196	7.28	No	No	8	9	9
106	R:R:F120	R:R:T116	6.49	No	No	0	5	4
107	R:R:T118	R:R:Y176	6.24	No	Yes	0	6	7
108	R:R:S180	R:R:T118	7.99	No	No	0	6	6
109	R:R:T123	R:R:Y119	8.74	No	No	4	6	6
110	R:R:F170	R:R:Y119	8.25	No	No	4	4	6
111	R:R:P177	R:R:Y119	12.52	No	No	0	6	6
112	R:R:G122	R:R:M173	3.49	No	Yes	0	6	8
113	R:R:S169	R:R:T123	6.4	No	No	0	8	6
114	R:R:F170	R:R:T123	11.67	No	No	4	4	6
115	R:R:V125	R:R:W326	4.9	No	Yes	0	7	8
116	R:R:S126	R:R:S169	4.89	Yes	No	0	7	8
117	R:R:M173	R:R:S126	4.6	Yes	Yes	0	8	7
118	R:R:L217	R:R:S126	6.01	Yes	Yes	0	7	7
119	R:R:N131	R:R:V127	4.43	No	No	0	8	8
120	R:R:V127	R:R:W166	17.16	No	Yes	0	8	9
121	R:R:L217	R:R:T129	4.42	Yes	No	0	7	8
122	R:R:P221	R:R:T129	3.5	No	No	0	9	8
123	R:R:F130	R:R:T165	5.19	No	No	0	6	7
124	R:R:L132	R:R:N366	6.87	No	Yes	2	8	9
125	R:R:L132	R:R:Y370	3.52	No	Yes	2	8	9
126	R:R:P221	R:R:V133	3.53	No	No	0	9	7
127	R:R:I135	R:R:R139	5.01	No	No	2	9	9
128	R:R:I135	R:R:Y370	4.84	No	Yes	2	9	9
129	R:R:S136	R:R:Y229	5.09	No	Yes	0	9	9
130	R:R:L137	R:R:V224	4.47	No	No	0	6	7
131	R:R:E138	R:R:Q153	3.82	Yes	Yes	0	9	7
132	R:R:E138	R:R:H157	8.62	Yes	Yes	0	9	7
133	R:R:R139	R:R:Y229	6.17	No	Yes	0	9	9
134	R:R:R139	R:R:Y370	5.14	No	Yes	2	9	9
135	R:R:A142	R:R:Q153	4.55	No	Yes	0	8	7
136	R:R:K145	R:R:Q148	23.05	Yes	No	0	6	5
137	R:R:S149	R:R:W152	9.88	No	Yes	9	8	5
138	R:R:Q153	R:R:S149	8.66	Yes	No	9	7	8
139	R:R:Q153	R:R:W152	13.14	Yes	Yes	9	7	5
140	R:R:H157	R:R:W152	4.23	Yes	Yes	0	7	5
141	R:R:H157	R:R:V161	6.92	Yes	No	0	7	6
142	R:R:I162	R:R:W166	4.7	No	Yes	4	7	9
143	R:R:F170	R:R:W166	5.01	No	Yes	4	4	9
144	R:R:I172	R:R:M173	4.37	No	Yes	0	6	8
145	R:R:M173	R:R:Y176	3.59	Yes	Yes	0	8	7
146	R:R:P175	R:R:T174	3.5	No	No	0	8	4
147	R:R:P175	R:R:W209	6.76	No	Yes	0	8	8
148	R:R:F198	R:R:Y176	19.6	Yes	Yes	5	5	7
149	R:R:W209	R:R:Y176	10.61	Yes	Yes	5	8	7
150	R:R:I178	R:R:Y179	9.67	No	No	0	5	5
151	R:R:F198	R:R:Y179	5.16	Yes	No	0	5	5
152	R:R:P201	R:R:Y179	6.95	No	No	0	5	5
153	R:R:L182	R:R:N194	13.73	No	No	0	5	3
154	R:R:P184	R:R:V183	3.53	No	No	0	1	3
155	R:R:M195	R:R:V183	9.13	No	No	0	4	3
156	R:R:F185	R:R:K187	7.44	No	No	1	4	2
157	R:R:A193	R:R:F185	5.55	No	No	1	3	4
158	R:R:A193	R:R:K187	4.82	No	No	1	3	2
159	R:R:N188	R:R:N189	13.62	No	No	0	1	4
160	R:R:N189	R:R:Q191	3.96	No	No	0	4	2
161	R:R:M195	R:R:R197	16.13	No	No	1	4	4
162	R:R:F198	R:R:L200	4.87	Yes	Yes	5	5	4
163	R:R:F198	R:R:W209	10.02	Yes	Yes	5	5	8
164	R:R:L199	R:R:Q206	6.65	No	No	0	4	5
165	R:R:L200	R:R:M205	11.31	Yes	Yes	0	4	4
166	R:R:L200	R:R:Q206	6.65	Yes	No	0	4	5
167	R:R:L200	R:R:W209	4.56	Yes	Yes	5	4	8
168	R:R:M205	R:R:P201	5.03	Yes	No	0	4	5
169	R:R:N202	R:R:V204	5.91	No	No	0	5	2
170	R:R:M205	R:R:N202	14.02	Yes	No	0	4	5
171	R:R:D203	R:R:Q207	9.14	No	No	0	2	4
172	R:R:H210	R:R:Q206	7.42	No	No	0	6	5
173	R:R:Q207	R:R:Y338	4.51	No	No	0	4	5
174	R:R:L213	R:R:W209	13.67	No	Yes	0	7	8
175	R:R:A337	R:R:H210	4.39	No	No	0	6	6
176	R:R:F212	R:R:I216	13.82	No	No	0	5	5
177	R:R:I216	R:R:L217	4.28	No	Yes	0	5	7
178	R:R:F330	R:R:L217	6.09	Yes	Yes	0	7	7
179	R:R:F218	R:R:L219	3.65	Yes	No	0	8	6
180	R:R:F218	R:R:M327	6.22	Yes	No	0	8	6
181	R:R:F218	R:R:F330	4.29	Yes	Yes	0	8	7
182	R:R:F323	R:R:M226	4.98	Yes	No	0	6	6
183	R:R:L315	R:R:Y229	12.89	No	Yes	0	8	9
184	R:R:I318	R:R:Y229	9.67	No	Yes	0	9	9
185	R:R:I312	R:R:S233	7.74	No	No	0	8	6
186	R:R:L315	R:R:S233	4.5	No	No	0	8	6
187	R:R:K308	R:R:L236	8.46	No	No	0	8	9
188	R:R:Q238	R:R:Y237	10.15	No	No	0	5	6
189	R:R:A307	R:R:R310	4.15	No	No	0	6	8
190	R:R:R310	R:R:V311	3.92	No	No	0	8	9
191	R:R:R310	R:R:R313	5.33	No	No	0	8	7
192	R:R:I369	R:R:M314	7.29	No	No	0	9	9
193	R:R:M314	R:R:M373	5.78	No	No	0	9	7
194	R:R:L321	R:R:V317	4.47	No	No	0	6	7
195	R:R:I318	R:R:Y370	4.84	No	Yes	0	9	9
196	R:R:L321	R:R:V365	4.47	No	No	0	6	7
197	R:R:F322	R:R:W326	8.02	No	Yes	0	9	8
198	R:R:C325	R:R:S362	3.44	No	No	0	8	9
199	R:R:F330	R:R:W326	6.01	Yes	Yes	0	7	8
200	R:R:S359	R:R:W326	4.94	No	Yes	0	7	8
201	R:R:S362	R:R:W326	8.65	No	Yes	0	9	8
202	R:R:I329	R:R:N333	5.66	No	No	0	7	7
203	R:R:I329	R:R:L356	4.28	No	Yes	0	7	6
204	R:R:D339	R:R:W335	8.93	No	Yes	0	4	5
205	R:R:A343	R:R:W335	11.67	No	Yes	0	4	5
206	R:R:R346	R:R:W335	4	No	Yes	0	4	5
207	R:R:L347	R:R:W335	5.69	No	Yes	0	5	5
208	R:R:R336	R:R:T340	3.88	Yes	No	6	4	2
209	R:R:E344	R:R:R336	9.3	Yes	Yes	6	1	4
210	R:R:D339	R:R:S342	4.42	No	No	0	4	4
211	R:R:E344	R:R:T340	9.88	Yes	No	6	1	2
212	R:R:P351	R:R:T350	5.25	No	No	0	4	3
213	R:R:F354	R:R:S353	5.28	No	No	0	4	5
214	R:R:L356	R:R:Y360	8.21	Yes	Yes	1	6	7
215	R:R:S359	R:R:Y360	6.36	No	Yes	0	7	7
216	R:R:N366	R:R:Y370	6.98	Yes	Yes	2	9	9
217	R:R:C371	R:R:F377	9.78	No	Yes	7	8	9
218	R:R:F372	R:R:F377	6.43	No	Yes	0	6	9
219	R:R:N374	R:R:R376	3.62	No	No	0	9	7
220	R:R:K375	R:R:R378	6.19	No	No	0	6	9
221	R:R:K375	R:R:L379	8.46	No	No	0	6	5
222	R:R:F381	R:R:M382	3.73	No	No	0	7	5
223	R:R:F381	R:R:F385	9.65	No	Yes	0	7	6
224	R:R:F385	R:R:T384	7.78	Yes	No	0	6	6
225	L:L:W5	R:R:L347	3.42	Yes	No	0	0	5
226	R:R:A228	R:R:S136	3.42	No	No	0	6	9
227	R:R:A84	R:R:V62	3.39	No	Yes	0	9	9
228	R:R:I220	R:R:P221	3.39	No	No	0	6	9
229	R:R:I355	R:R:P328	3.39	No	No	0	6	9
230	R:R:C364	R:R:I51	3.27	No	Yes	0	7	7
231	R:R:A84	R:R:I63	3.25	No	No	0	9	7
232	R:R:A140	R:R:I232	3.25	No	No	0	8	9
233	R:R:F218	R:R:F323	3.22	Yes	Yes	0	8	6
234	R:R:V133	R:R:V224	3.21	No	No	0	7	7
235	R:R:P41	R:R:Q40	3.16	No	No	0	4	1
236	R:R:E38	R:R:P41	3.14	No	No	0	3	4
237	R:R:T74	R:R:T76	3.14	No	No	0	7	8
238	R:R:I63	R:R:V85	3.07	No	No	0	7	6
239	R:R:M225	R:R:S136	3.07	No	No	0	8	9
240	R:R:I369	R:R:V365	3.07	No	No	0	9	7
241	R:R:F372	R:R:G58	3.01	No	No	0	6	8
242	R:R:F323	R:R:G222	3.01	Yes	No	0	6	6
243	R:R:L182	R:R:S111	3	No	No	0	5	4
244	R:R:L47	R:R:V43	2.98	No	No	0	5	5
245	R:R:L231	R:R:V227	2.98	No	No	0	5	5
246	R:R:L61	R:R:T60	2.95	No	No	0	7	4
247	R:R:I318	R:R:I369	2.94	No	No	0	9	9
248	R:R:I329	R:R:I355	2.94	No	No	0	7	6
249	R:R:I51	R:R:M95	2.92	Yes	No	0	7	7
250	R:R:I172	R:R:L168	2.85	No	No	0	6	5
251	R:R:I232	R:R:L315	2.85	No	No	0	9	8
252	R:R:K308	R:R:L305	2.82	No	No	0	8	4
253	R:R:A158	R:R:F79	2.77	No	Yes	0	7	8
254	R:R:L214	R:R:L219	2.77	No	No	0	7	6
255	R:R:L88	R:R:N59	2.75	No	Yes	0	7	9
256	R:R:F130	R:R:S126	2.64	No	Yes	0	6	7
257	R:R:R345	R:R:S342	2.64	No	No	0	5	4
258	R:R:F323	R:R:V319	2.62	Yes	No	0	6	8
259	R:R:F354	R:R:T350	2.59	No	No	0	4	3
260	R:R:F372	R:R:I368	2.51	No	No	0	6	6
261	R:R:K70	R:R:R73	2.48	No	No	0	7	8
262	R:R:L147	R:R:R150	2.43	No	No	0	7	6
263	R:R:Q40	R:R:W39	2.19	No	No	0	1	1
264	R:R:G349	R:R:P351	2.03	No	No	0	3	4
265	L:L:?2	R:R:N102	1.97	Yes	No	0	0	6
266	R:R:A140	R:R:G141	1.95	No	No	0	8	6
267	R:R:A383	R:R:G380	1.95	No	No	0	5	8
268	R:R:P367	R:R:V62	1.77	No	Yes	0	9	9
269	R:R:G380	R:R:L379	1.71	No	No	0	8	5
270	R:R:I45	R:R:P41	1.69	No	No	0	5	4
271	R:R:C325	R:R:T361	1.69	No	No	0	8	5
272	R:R:C364	R:R:T361	1.69	No	No	0	7	5
273	R:R:K145	R:R:P146	1.67	Yes	No	0	6	8
274	R:R:L147	R:R:P146	1.64	No	No	0	7	8
275	R:R:L358	R:R:P328	1.64	No	No	0	8	9
276	R:R:C144	R:R:K145	1.62	No	Yes	0	7	6
277	R:R:A332	R:R:I352	1.62	No	No	0	5	5
278	R:R:S156	R:R:T154	1.6	No	No	0	5	8
279	R:R:C144	R:R:L231	1.59	No	No	0	7	5
280	R:R:A334	R:R:L214	1.58	No	No	0	6	7
281	R:R:I223	R:R:V227	1.54	No	No	0	4	5
282	R:R:I316	R:R:V320	1.54	No	No	0	7	6
283	R:R:K145	R:R:S149	1.53	Yes	No	0	6	8
284	R:R:M205	R:R:S208	1.53	Yes	No	0	4	4
285	R:R:C144	R:R:E235	1.52	No	No	0	7	6
286	R:R:A337	R:R:Q207	1.52	No	No	0	6	4
287	R:R:F109	R:R:G110	1.51	Yes	No	0	6	7
288	R:R:L46	R:R:S49	1.5	No	No	0	4	4
289	R:R:L236	R:R:V311	1.49	No	No	0	9	9
290	R:R:L321	R:R:V320	1.49	No	No	0	6	6
291	R:R:L324	R:R:V320	1.49	No	No	0	5	6
292	R:R:N181	R:R:V183	1.48	No	No	0	5	3
293	R:R:L80	R:R:T76	1.47	No	No	0	8	8
294	R:R:I162	R:R:I78	1.47	No	No	0	7	5
295	R:R:I143	R:R:I232	1.47	No	No	0	9	9
296	R:R:L215	R:R:T211	1.47	No	No	0	3	6
297	R:R:F385	R:R:P386	1.44	Yes	No	0	6	1
298	R:R:I51	R:R:L50	1.43	Yes	No	0	7	4
299	R:R:I67	R:R:L81	1.43	No	No	0	3	6
300	R:R:I216	R:R:L215	1.43	No	No	0	5	3
301	L:L:D1	L:L:M3	1.39	No	No	0	0	0
302	R:R:L53	R:R:L54	1.38	No	No	0	4	5
303	R:R:L53	R:R:L57	1.38	No	No	0	4	4
304	R:R:H157	R:R:T154	1.37	Yes	No	0	7	8
305	R:R:E235	R:R:L234	1.33	No	No	0	6	4
306	R:R:K155	R:R:R73	1.24	No	No	0	4	8
307	R:R:V151	R:R:W152	1.23	No	Yes	0	5	5
308	R:R:I312	R:R:Y237	1.21	No	No	0	8	6
309	R:R:F377	R:R:N374	1.21	Yes	No	0	9	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?2	7.32571	7	1	0
2	L:L:W5	12.588	5	0	0
3	L:L:D7	7.04	4	0	0
4	L:L:?101	6.87	4	1	0
5	R:R:Q44	6.515	4	3	4
6	R:R:Y48	8.505	4	3	7
7	R:R:I51	3.69	4	0	7
8	R:R:F52	5.0175	4	0	5
9	R:R:N59	5.1175	4	0	9
10	R:R:V62	3.5525	4	7	9
11	R:R:F79	4.82	5	0	8
12	R:R:D87	7.2125	4	2	9
13	R:R:N98	6.408	5	1	7
14	R:R:L99	8.475	4	3	6
15	R:R:F107	8.0425	4	8	8
16	R:R:F109	7.028	5	0	6
17	R:R:S126	4.535	4	0	7
18	R:R:E138	6.22	4	0	9
19	R:R:K145	6.9675	4	0	6
20	R:R:W152	7.12	4	9	5
21	R:R:Q153	7.5425	4	9	7
22	R:R:H157	5.285	4	0	7
23	R:R:W166	7.292	5	4	9
24	R:R:M173	4.0125	4	0	8
25	R:R:Y176	9.23833	6	5	7
26	R:R:F198	9.9125	4	5	5
27	R:R:L200	6.8475	4	5	4
28	R:R:M205	7.9725	4	0	4
29	R:R:W209	9.124	5	5	8
30	R:R:L217	5.2	4	0	7
31	R:R:F218	4.345	4	0	8
32	R:R:Y229	8.455	4	0	9
33	R:R:F323	3.4575	4	0	6
34	R:R:W326	6.504	5	0	8
35	R:R:F330	5.4375	4	0	7
36	R:R:W335	7.5725	4	0	5
37	R:R:R336	10.435	4	6	4
38	R:R:E344	8.125	4	6	1
39	R:R:L356	6.7225	4	1	6
40	R:R:Y360	8.274	5	1	7
41	R:R:N366	7.205	4	2	9
42	R:R:Y370	4.80667	6	2	9
43	R:R:F377	6.106	5	7	9
44	R:R:F385	5.69	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:W5	R:R:N333	15.7099	5.65	Yes	No	0	0	7
2	L:L:D7	R:R:N333	35.0379	4.04	Yes	No	0	0	7
3	L:L:D7	R:R:R336	10.9218	3.57	Yes	Yes	0	0	4
4	L:L:D7	R:R:Y176	32.6352	9.2	Yes	Yes	0	0	7
5	L:L:?2	L:L:M6	12.0439	5.07	Yes	No	1	0	0
6	L:L:M6	R:R:N98	11.7618	4.21	No	Yes	1	0	7
7	R:R:N98	R:R:Y360	12.4086	9.3	Yes	Yes	1	7	7
8	R:R:S359	R:R:Y360	38.4954	6.36	No	Yes	0	7	7
9	R:R:S359	R:R:W326	38.031	4.94	No	Yes	0	7	8
10	R:R:F330	R:R:W326	41.3409	6.01	Yes	Yes	0	7	8
11	L:L:F8	R:R:F330	27.2133	5.36	No	Yes	0	0	7
12	L:L:F8	R:R:Y176	26.8357	6.19	No	Yes	0	0	7
13	R:R:M95	R:R:Y360	100	10.78	No	Yes	0	7	7
14	R:R:I51	R:R:M95	19.7209	2.92	Yes	No	0	7	7
15	R:R:I51	R:R:L357	16.348	7.14	Yes	No	0	7	7
16	R:R:L357	R:R:Y48	13.7043	11.72	No	Yes	0	7	7
17	R:R:F52	R:R:M95	98.6369	6.22	Yes	No	0	5	7
18	R:R:C91	R:R:F52	98.37	5.59	No	Yes	0	7	5
19	R:R:C91	R:R:S55	98.2766	5.16	No	No	0	7	8
20	R:R:N59	R:R:S55	56.6405	4.47	Yes	No	0	9	8
21	R:R:S363	R:R:S55	41.6969	4.89	No	No	0	9	8
22	R:R:D87	R:R:N59	47.5658	6.73	Yes	Yes	0	9	9
23	R:R:D87	R:R:S363	41.3474	5.89	Yes	No	0	9	9
24	R:R:N59	R:R:P367	20.1376	6.52	Yes	No	0	9	9
25	R:R:P367	R:R:V62	19.5082	1.77	No	Yes	0	9	9
26	R:R:F377	R:R:V62	14.4054	3.93	Yes	Yes	7	9	9
27	R:R:F377	R:R:V65	15.3279	9.18	Yes	No	0	9	8
28	R:R:N69	R:R:V65	14.4792	4.43	No	No	0	6	8
29	R:R:C94	R:R:L90	15.0544	6.35	No	No	0	7	8
30	R:R:L90	R:R:S124	14.1384	9.01	No	No	0	8	6
31	R:R:M89	R:R:S124	13.3527	4.6	No	No	0	7	6
32	R:R:M89	R:R:W166	11.1909	4.65	No	Yes	0	7	9
33	R:R:C94	R:R:Y360	14.8438	6.72	No	Yes	0	7	7
34	R:R:D87	R:R:N366	85.5534	6.73	Yes	Yes	2	9	9
35	R:R:N366	R:R:Y370	83.626	6.98	Yes	Yes	2	9	9
36	R:R:I135	R:R:Y370	37.7813	4.84	No	Yes	2	9	9
37	R:R:F79	R:R:I135	37.7076	3.77	Yes	No	0	8	9
38	R:R:E138	R:R:F79	27.3891	8.16	Yes	Yes	0	9	8
39	R:R:T118	R:R:Y176	23.8838	6.24	No	Yes	0	6	7
40	R:R:S180	R:R:T118	22.5012	7.99	No	No	0	6	6
41	R:R:C114	R:R:S180	21.1143	5.16	No	No	0	9	6
42	R:R:C114	R:R:F107	18.2992	4.19	No	Yes	8	9	8
43	R:R:F107	R:R:F109	11.4536	10.72	Yes	Yes	0	8	6
44	R:R:F330	R:R:L217	14.9437	6.09	Yes	Yes	0	7	7
45	R:R:M173	R:R:Y176	11.9115	3.59	Yes	Yes	0	8	7
46	R:R:R139	R:R:Y370	15.8791	5.14	No	Yes	2	9	9
47	R:R:R139	R:R:Y229	15.7598	6.17	No	Yes	0	9	9
48	R:R:I318	R:R:Y370	26.7076	4.84	No	Yes	0	9	9
49	R:R:I318	R:R:Y229	15.0131	9.67	No	Yes	0	9	9
50	R:R:E138	R:R:Q153	19.2108	3.82	Yes	Yes	0	9	7
51	R:R:Q153	R:R:S149	14.3967	8.66	Yes	No	9	7	8
52	R:R:K145	R:R:S149	13.344	1.53	Yes	No	0	6	8
53	R:R:W209	R:R:Y176	12.8253	10.61	Yes	Yes	5	8	7
54	R:R:F198	R:R:Y176	12.9251	19.6	Yes	Yes	5	5	7
55	R:R:L200	R:R:M205	13.9062	11.31	Yes	Yes	0	4	4
56	R:R:L315	R:R:Y229	21.4768	12.89	No	Yes	0	8	9
57	R:R:I318	R:R:I369	11.1454	2.94	No	No	0	9	9
58	R:R:I329	R:R:L356	43.837	4.28	No	Yes	0	7	6
59	R:R:I329	R:R:N333	42.2829	5.66	No	No	0	7	7
60	R:R:L356	R:R:Y360	43.7328	8.21	Yes	Yes	1	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?2	R:R:P101	9.42	1	Yes	No	0	5	0	1
L:L:?2	R:R:K105	4.04	1	Yes	No	0	4	0	1
L:L:?2	R:R:F185	7.86	1	Yes	No	0	4	0	1
L:L:?2	R:R:M195	8.11	1	Yes	No	0	4	0	1
L:L:?2	R:R:R197	14.81	1	Yes	No	0	4	0	1
L:L:M3	R:R:E344	6.77	0	No	Yes	0	1	0	1
L:L:M3	R:R:S348	4.6	0	No	No	0	5	0	1
L:L:G4	R:R:R197	4.5	0	No	No	0	4	0	1
L:L:G4	R:R:E344	6.55	0	No	Yes	0	1	0	1
L:L:W5	R:R:N333	5.65	0	Yes	No	0	7	0	1
L:L:W5	R:R:R336	24.99	0	Yes	Yes	0	4	0	1
L:L:W5	R:R:I352	24.66	0	Yes	No	0	5	0	1
L:L:M6	R:R:N98	4.21	1	No	Yes	0	7	0	1
L:L:D7	R:R:Y176	9.2	0	Yes	Yes	0	7	0	1
L:L:D7	R:R:H210	11.35	0	Yes	No	0	6	0	1
L:L:D7	R:R:N333	4.04	0	Yes	No	0	7	0	1
L:L:D7	R:R:R336	3.57	0	Yes	Yes	0	4	0	1
L:L:F8	R:R:Y176	6.19	0	No	Yes	0	7	0	1
L:L:F8	R:R:F330	5.36	0	No	Yes	0	7	0	1
L:L:?101	R:R:N98	10.2	1	Yes	Yes	0	7	0	1
L:L:?101	R:R:M121	3.5	1	Yes	No	0	7	0	1
L:L:?101	R:R:L356	10.28	1	Yes	Yes	0	6	0	1
R:R:C94	R:R:M121	8.1	0	No	No	7	7	2	1
R:R:C94	R:R:Y360	6.72	0	No	Yes	7	7	2	2
R:R:M121	R:R:N98	4.21	1	No	Yes	7	7	1	1
R:R:L356	R:R:N98	4.12	1	Yes	Yes	6	7	1	1
R:R:N98	R:R:Y360	9.3	1	Yes	Yes	7	7	1	2
R:R:I100	R:R:P101	6.77	0	No	No	5	5	2	1
R:R:T118	R:R:Y176	6.24	0	No	Yes	6	7	2	1
R:R:M173	R:R:Y176	3.59	0	Yes	Yes	8	7	2	1
R:R:F198	R:R:Y176	19.6	5	Yes	Yes	5	7	2	1
R:R:W209	R:R:Y176	10.61	5	Yes	Yes	8	7	2	1
R:R:M195	R:R:V183	9.13	1	No	No	4	3	1	2
R:R:F185	R:R:K187	7.44	1	No	No	4	2	1	2
R:R:A193	R:R:F185	5.55	1	No	No	3	4	2	1
R:R:A193	R:R:K187	4.82	1	No	No	3	2	2	2
R:R:M195	R:R:R197	16.13	1	No	No	4	4	1	1
R:R:F198	R:R:W209	10.02	5	Yes	Yes	5	8	2	2
R:R:H210	R:R:Q206	7.42	0	No	No	6	5	1	2
R:R:A337	R:R:H210	4.39	0	No	No	6	6	2	1
R:R:F330	R:R:L217	6.09	0	Yes	Yes	7	7	1	2
R:R:F218	R:R:F330	4.29	0	Yes	Yes	8	7	2	1
R:R:F330	R:R:W326	6.01	0	Yes	Yes	7	8	1	2
R:R:I329	R:R:N333	5.66	0	No	No	7	7	2	1
R:R:I329	R:R:L356	4.28	0	No	Yes	7	6	2	1
R:R:L347	R:R:W335	5.69	0	No	Yes	5	5	1	2
R:R:R336	R:R:T340	3.88	6	Yes	No	4	2	1	2
R:R:E344	R:R:R336	9.3	6	Yes	Yes	1	4	1	1
R:R:E344	R:R:T340	9.88	6	Yes	No	1	2	1	2
R:R:L356	R:R:Y360	8.21	1	Yes	Yes	6	7	1	2
L:L:W5	R:R:L347	3.42	0	Yes	No	0	5	0	1
L:L:?2	R:R:N102	1.97	1	Yes	No	0	6	0	1
R:R:A332	R:R:I352	1.62	0	No	No	5	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9BKJ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.44
Number of Linked Nodes	275
Number of Links	309
Number of Hubs	44
Number of Links mediated by Hubs	157
Number of Communities	9
Number of Nodes involved in Communities	47
Number of Links involved in Communities	60

Path Summary
Number Of Nodes in MetaPath	61
Number Of Links MetaPath	60
Number of Shortest Paths	76677
Length Of Smallest Path	3
Average Path Length	15.9913
Length of Longest Path	32
Minimum Path Strength	1.38
Average Path Strength	6.20501
Maximum Path Strength	19.65
Minimum Path Correlation	0.7
Average Path Correlation	0.924628
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	44.4927
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.753
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • amide binding • binding • peptide hormone binding • hormone binding • peptide receptor activity • molecular transducer activity • cholecystokinin receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • cholecystokinin signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • developmental process • multicellular organismal process • head development • forebrain development • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • anatomical structure development • system development • regulation of localization • regulation of hormone secretion • transport • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of biological quality • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • cell-cell signaling • establishment of localization • regulation of secretion • regulation of cell communication • hormone transport • phospholipase C-activating G protein-coupled receptor signaling pathway • neuron migration • cellular developmental process • generation of neurons • neurogenesis • cell differentiation • cell migration • cell motility • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • axonogenesis • cell projection organization • plasma membrane bounded cell projection morphogenesis • cell development • neuron projection development • cell morphogenesis • cellular component organization • cell projection morphogenesis • neuron differentiation • neuron projection morphogenesis • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • axon development • cell morphogenesis involved in neuron differentiation • anatomical structure morphogenesis • neuron development • hormone activity • protein binding • molecular function activator activity • signaling receptor binding • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • neuropeptide activity • neuropeptide hormone activity • peptide hormone receptor binding • hormone receptor binding • behavior • eating behavior • feeding behavior • digestion • axon • neuron projection • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	TYS
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	TYS
Name	O-SULFO-L-TYROSINE
Synonyms
Identifier
Formula	C9 H11 N O6 S
Molecular Weight	261.252
SMILES
PubChem	514186
Formal Charge	0
Total Atoms	28
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	6


Code	NH2
PDB Residues	L:L:?101
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32238
Sequence	>9BKJ_nogp_Chain_R E W Q P A V Q I L L Y S L I F L L S V L G N T L V I T V L I R N K R M R T V T N I F L L S L A V S D L M L C L F C M P F N L I P N L L K D F I F G S A V C K T T T Y F M G T S V S V S T F N L V A I S L E R A G A I C K P L Q S R V W Q T K S H A L K V I A A T W C L S F T I M T P Y P I Y S N L V P F T K N N N Q T A N M C R F L L P N D V M Q Q S W H T F L L L I L F L I P G I V M M V A Y G L I S L E L Y Q L M A K K R V I R M L I V I V V L F F L C W M P I F S A N A W R A Y D T A S A E R R L S G T P I S F I L L L S Y T S S C V N P I I Y C F M N K R F R L G F M A T F P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XOU	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	Gs/β1/γ2	3.2	2022-07-20	doi.org/10.1038/s41421-022-00420-3
	7XOU (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		3.2	2022-07-20	doi.org/10.1038/s41421-022-00420-3
	7XOV	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	SR146131	-	Gs/β1/γ2	3	2022-07-20	doi.org/10.1038/s41421-022-00420-3
	7XOV (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	SR146131	-		3	2022-07-20	doi.org/10.1038/s41421-022-00420-3
	7EZH	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	Gi1/β1/γ2	3.2	2021-08-25	doi.org/10.1038/s41589-021-00841-3
	7EZH (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		3.2	2021-08-25	doi.org/10.1038/s41589-021-00841-3
	7EZK	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1-Gs)/β1/γ2	3.1	2021-08-25	doi.org/10.1038/s41589-021-00841-3
	7EZK (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		3.1	2021-08-25	doi.org/10.1038/s41589-021-00841-3
	7EZM	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGsL-Gq)/β1/γ2	2.9	2021-08-25	doi.org/10.1038/s41589-021-00841-3
	7EZM (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.9	2021-08-25	doi.org/10.1038/s41589-021-00841-3
	7F8U	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Lintitript	-	-	2.8	2021-10-13	doi.org/10.1038/s41589-021-00866-8
	7F8Y	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Devazepide	-	-	2.5	2021-10-13	doi.org/10.1038/s41589-021-00866-8
	7F8X	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	NN9056	-	-	3	2021-12-29	doi.org/10.1038/s41589-021-00866-8
	7MBX	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	Gs/β1/γ1	1.95	2021-05-26	doi.org/10.1371/journal.pbio.3001295
	7MBX (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		1.95	2021-05-26	doi.org/10.1371/journal.pbio.3001295
	7MBY	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.44	2021-05-26	doi.org/10.1371/journal.pbio.3001295
	7MBY (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.44	2021-05-26	doi.org/10.1371/journal.pbio.3001295
	9BKJ	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.59	2024-05-22	doi.org/10.1371/journal.pbio.3002673
	9BKJ (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.59	2024-05-22	doi.org/10.1371/journal.pbio.3002673
	9BKK	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.51	2024-05-22	doi.org/10.1371/journal.pbio.3002673
	9BKK (No Gprot)	A	Peptide	Cholecystokinin	CCK_A	Homo sapiens	Cholecystokinin-8	-		2.51	2024-05-22	doi.org/10.1371/journal.pbio.3002673

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