Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:Q6 5.92254160
2L:L:V13 3.84754190
3L:L:Q17 4.4400
4L:L:Y31 5.948510
5L:L:D33 2.6775400
6L:L:Y37 5.865610
7L:L:W40 7.867147160
8L:L:F41 6.68410
9L:L:Q42 5.5225400
10L:L:R44 3.0525400
11L:L:R51 6.195410
12L:L:Y54 8.4925410
13L:L:R66 5.745100
14L:L:F67 5.58754100
15L:L:F76 4.065400
16L:L:Y91 4.51754100
17L:L:Y92 6.7525400
18L:L:M94 7.668510
19L:L:W99 6.57510
20L:L:F103 9.8275410
21N:N:L4 3.9425440
22N:N:Q6 4.305640
23N:N:Y27 5.242540
24N:N:Y32 5.6025440
25N:N:W36 7.51333640
26N:N:R38 8.754200
27N:N:I45 8.68400
28N:N:W47 7.43333600
29N:N:M48 4.684200
30N:N:W50 5.63429710
31N:N:S52 4.67410
32N:N:N55 5.624510
33N:N:Y60 6.4475400
34N:N:V68 2.9375400
35N:N:D90 4.76254210
36N:N:Y95 6.1225400
37N:N:C96 6.272540
38N:N:R98 7.5675440
39N:N:H99 5.792510
40N:N:Y107 5.7775410
41N:N:Y108 7.4775400
42N:N:H110 10.8875410
43N:N:Y111 5.492510
44N:N:W116 5.968500
45R:R:P27 5.0575415
46R:R:F29 9.4475414
47R:R:I39 6.085475
48R:R:F40 6.654505
49R:R:L41 4.5725406
50R:R:T43 3.7425474
51R:R:Y45 5.44407
52R:R:D74 5.6725408
53R:R:H79 4.055409
54R:R:D84 6.61754239
55R:R:F87 7.215407
56R:R:W102 7.441676249
57R:R:F104 8.7275407
58R:R:H113 5.05754116
59R:R:Y121 6.734257
60R:R:S122 3.1125407
61R:R:R148 7.5725406
62R:R:V160 6.2407
63R:R:D171 7.114114
64R:R:F189 5.895403
65R:R:Y190 7.818504
66R:R:L226 2.494268
67R:R:F249 5.5504
68R:R:W252 6.3775409
69R:R:P254 4.485489
70R:R:Y256 8.52408
71R:R:W283 5.952586
72R:R:C296 4.8054227
73R:R:N298 8.22254239
74R:R:L305 3.5125406
75M:M:Q6 5.92254170
76M:M:V13 3.84754270
77M:M:Q17 4.4400
78M:M:Y31 5.948520
79M:M:D33 2.6775400
80M:M:Y37 5.865620
81M:M:W40 7.867147170
82M:M:F41 6.68420
83M:M:Q42 5.5225400
84M:M:R44 3.0525400
85M:M:R51 6.195420
86M:M:Y54 8.4925420
87M:M:R66 5.745120
88M:M:F67 5.58754120
89M:M:F76 4.065400
90M:M:Y91 4.51754120
91M:M:Y92 6.7525400
92M:M:M94 7.668520
93M:M:W99 6.156520
94M:M:F103 9.8275420
95J:J:L4 3.9425450
96J:J:Q6 4.305650
97J:J:Y27 5.242550
98J:J:Y32 5.6025450
99J:J:W36 7.51333650
100J:J:R38 8.754280
101J:J:I45 8.68400
102J:J:W47 7.27667600
103J:J:M48 4.684280
104J:J:W50 5.63429720
105J:J:S52 4.67420
106J:J:N55 5.624520
107J:J:Y60 6.4475400
108J:J:V68 2.9375400
109J:J:D90 4.76254290
110J:J:Y95 6.1225400
111J:J:C96 6.272550
112J:J:R98 7.5675450
113J:J:H99 5.792520
114J:J:Y107 5.7775420
115J:J:Y108 7.735400
116J:J:H110 10.8875420
117J:J:Y111 5.492520
118J:J:W116 5.968500
119S:S:P27 5.0575425
120S:S:F29 9.4475424
121S:S:I39 6.085485
122S:S:F40 6.654505
123S:S:L41 4.5725406
124S:S:T43 3.7425484
125S:S:Y45 5.44407
126S:S:D74 5.6725408
127S:S:H79 4.055409
128S:S:D84 6.61754319
129S:S:F87 7.215407
130S:S:W102 7.441676329
131S:S:F104 8.7275407
132S:S:H113 5.05754136
133S:S:Y121 6.734337
134S:S:S122 3.1125407
135S:S:R148 7.5725406
136S:S:V160 6.2407
137S:S:D171 7.114134
138S:S:F189 5.895403
139S:S:Y190 7.818504
140S:S:L226 2.494348
141S:S:F249 5.5504
142S:S:W252 6.6275409
143S:S:P254 4.485499
144S:S:Y256 8.52408
145S:S:W283 5.952596
146S:S:C296 4.8054307
147S:S:N298 8.22254319
148S:S:L305 3.5125406
149U:U:Q6 5.92254180
150U:U:V13 3.84754350
151U:U:Q17 4.4400
152U:U:Y31 5.948530
153U:U:D33 2.6775400
154U:U:Y37 5.865630
155U:U:W40 7.867147180
156U:U:F41 6.68430
157U:U:Q42 5.5225400
158U:U:R44 3.0525400
159U:U:R51 6.195430
160U:U:Y54 8.4925430
161U:U:R66 5.745140
162U:U:F67 5.58754140
163U:U:F76 4.065400
164U:U:Y91 4.51754140
165U:U:Y92 6.7525400
166U:U:M94 7.668530
167U:U:W99 6.382530
168U:U:F103 9.8275430
169Y:Y:L4 3.9425460
170Y:Y:Q6 4.305660
171Y:Y:Y27 5.242560
172Y:Y:Y32 5.6025460
173Y:Y:W36 7.51333660
174Y:Y:R38 8.754360
175Y:Y:I45 8.68400
176Y:Y:W47 7.27667600
177Y:Y:M48 4.684360
178Y:Y:W50 5.63429730
179Y:Y:S52 4.67430
180Y:Y:N55 5.624530
181Y:Y:Y60 6.4475400
182Y:Y:V68 2.9375400
183Y:Y:D90 4.76254370
184Y:Y:Y95 6.1225400
185Y:Y:C96 6.272560
186Y:Y:R98 7.5675460
187Y:Y:H99 5.792530
188Y:Y:Y107 5.7775430
189Y:Y:Y108 7.4775400
190Y:Y:H110 10.8875430
191Y:Y:Y111 5.492530
192Y:Y:W116 5.968500
193P:P:P27 5.0575435
194P:P:F29 9.4475434
195P:P:I39 6.085495
196P:P:F40 6.654505
197P:P:L41 4.5725406
198P:P:T43 3.7425494
199P:P:Y45 5.44407
200P:P:D74 5.6725408
201P:P:H79 4.055409
202P:P:D84 6.61754399
203P:P:F87 7.215407
204P:P:W102 7.441676409
205P:P:F104 8.7275407
206P:P:H113 5.05754156
207P:P:Y121 6.734417
208P:P:S122 3.1125407
209P:P:R148 7.5725406
210P:P:V160 6.2407
211P:P:D171 7.114154
212P:P:F189 5.895403
213P:P:Y190 7.818504
214P:P:L226 2.494428
215P:P:F249 5.5504
216P:P:W252 6.3775409
217P:P:P254 4.485479
218P:P:Y256 8.52408
219P:P:W283 5.952576
220P:P:C296 4.8054387
221P:P:N298 8.22254399
222P:P:L305 3.5125406
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:W99 N:N:W47 13.46076.56YesYes000
2L:L:W99 N:N:Y109 17.72776.75YesNo100
3L:L:Y31 N:N:Y109 24.46756.95YesNo100
4L:L:F103 N:N:I45 10.121716.33YesYes000
5L:L:Y31 N:N:H110 21.26887.62YesYes100
6N:N:H110 N:N:Y111 18.573811.98YesYes100
7L:L:F41 L:L:R51 14.11985.34YesYes100
8L:L:R51 R:R:D181 21.10565.96YesNo102
9N:N:G49 N:N:W47 12.11168.44NoYes000
10N:N:G49 N:N:M48 11.82313.49NoYes000
11N:N:Y111 R:R:R183 21.95983.09YesNo003
12R:R:D97 R:R:R183 21.84933.57NoNo053
13R:R:D97 R:R:W102 21.81364.47NoYes059
14R:R:F104 R:R:W102 21.609412.03YesYes079
15R:R:F104 R:R:F93 21.507412.86YesNo076
16R:R:F93 R:R:V112 21.47385.24NoNo065
17R:R:V112 R:R:W94 18.20614.9NoNo1157
18R:R:H113 R:R:W94 19.33086.35YesNo1167
19R:R:H113 R:R:R188 19.39673.39YesNo1165
20R:R:R188 R:R:Y190 20.41769.26NoYes054
21N:N:H110 N:N:Y108 30.03476.53YesYes000
22N:N:Y108 R:R:R30 30.83255.14YesNo005
23R:R:H281 R:R:R30 30.967610.16NoNo045
24R:R:V196 R:R:Y190 22.44186.31NoYes044
25R:R:Q200 R:R:V196 22.74854.3NoNo054
26R:R:I259 R:R:Q200 24.02326.86NoNo055
27R:R:I259 R:R:Y255 19.031312.09NoNo057
28R:R:E288 R:R:Y255 18.923114.59NoNo057
29R:R:E288 R:R:Y116 18.81873.37NoNo056
30R:R:F87 R:R:Y116 49.2114.13YesNo076
31R:R:F292 R:R:F87 54.257513.93NoYes077
32R:R:F292 R:R:Y45 54.12056.19NoYes077
33R:R:L41 R:R:Y45 58.21119.38YesYes067
34R:R:L41 R:R:N37 57.48044.12YesNo063
35R:R:N33 R:R:N37 57.33425.45NoNo063
36R:R:F36 R:R:N33 57.18878.46NoNo046
37R:R:D262 R:R:H281 31.70917.56NoNo054
38R:R:D262 R:R:I284 31.90464.2NoNo054
39R:R:I284 R:R:V280 32.05883.07NoNo045
40R:R:V280 S:S:I39 32.24093.07NoYes855
41R:R:W283 S:S:I39 33.955310.57YesYes865
42R:R:P254 R:R:W283 47.68054.05YesYes896
43R:R:P254 S:S:I47 47.76373.39YesNo894
44R:R:L253 S:S:I47 95.43914.28NoNo054
45R:R:L208 R:R:L253 66.36564.15NoNo085
46R:R:L208 R:R:Y256 66.261711.72NoYes088
47R:R:H203 R:R:Y256 32.40819.8NoYes048
48R:R:H203 R:R:Y121 32.260514.16NoYes047
49R:R:L120 R:R:Y121 30.65413.52NoYes077
50R:R:L120 R:R:Y116 30.55344.69NoNo076
51R:R:W283 S:S:T43 47.76853.64YesYes864
52S:S:I47 S:S:T43 47.76413.04NoYes844
53R:R:F36 R:R:F40 56.752915NoYes045
54P:P:W283 R:R:F40 55.3783.01YesYes065
55P:P:W283 R:R:I39 54.748810.57YesYes765
56P:P:V280 R:R:I39 54.10033.07NoYes755
57R:R:D74 R:R:T73 12.0722.89YesNo087
58R:R:L305 R:R:T73 12.63114.42YesNo067
59R:R:L305 R:R:R77 54.93723.64YesNo068
60R:R:R77 R:R:V59 55.49243.92NoNo088
61R:R:S81 R:R:V59 56.05296.46NoNo098
62R:R:W252 R:R:Y256 28.53497.72YesYes098
63R:R:H294 R:R:W252 56.39798.46NoYes099
64R:R:H294 R:R:N298 53.255120.41NoYes099
65R:R:D84 R:R:N298 26.92356.73YesYes2399
66R:R:D84 R:R:N56 30.1876.73YesNo099
67R:R:N56 R:R:S81 54.83462.98NoNo099
68R:R:F249 R:R:L253 29.03499.74YesNo045
69R:R:F248 R:R:F249 28.59564.29NoYes094
70R:R:F248 R:R:W252 28.49288.02NoYes099
71R:R:N298 R:R:P299 25.791.63YesNo099
72R:R:N56 R:R:P299 25.45071.63NoNo099
73P:P:I284 P:P:V280 54.10343.07NoNo045
74P:P:D262 P:P:I284 54.17414.2NoNo054
75P:P:D262 P:P:H281 54.11117.56NoNo054
76P:P:H281 P:P:R30 53.859710.16NoNo045
77P:P:R30 Y:Y:Y108 53.79665.14NoYes050
78Y:Y:H110 Y:Y:Y108 53.4236.53YesYes000
79Y:Y:H110 Y:Y:Y111 43.72611.98YesYes300
80P:P:R183 Y:Y:Y111 35.6223.09NoYes030
81P:P:D97 P:P:R183 35.28963.57NoNo053
82P:P:D97 P:P:W102 35.1864.47NoYes059
83P:P:F104 P:P:W102 34.569612.03YesYes079
84P:P:F104 P:P:F93 34.357812.86YesNo076
85P:P:F93 P:P:V112 34.28955.24NoNo065
86P:P:V112 P:P:W94 22.50824.9NoNo1557
87P:P:H113 P:P:W94 22.79936.35YesNo1567
88P:P:H113 P:P:R188 22.02843.39YesNo1565
89P:P:R188 P:P:Y190 22.21269.26NoYes054
90P:P:V196 P:P:Y190 21.11776.31NoYes044
91P:P:Q200 P:P:V196 21.00884.3NoNo054
92P:P:I259 P:P:Q200 20.62596.86NoNo055
93P:P:T90 P:P:V112 11.71583.17NoNo1565
94P:P:I115 P:P:T90 11.92173.04NoNo056
95P:P:I115 P:P:L86 11.76052.85NoNo057
96P:P:L86 P:P:V82 11.68611.49NoNo075
97P:P:L78 P:P:V82 11.66061.49NoNo055
98P:P:L78 P:P:R70 11.64124.86NoNo056
99P:P:D74 P:P:R70 11.60565.96YesNo086
100P:P:D74 P:P:T73 11.40592.89YesNo087
101P:P:L305 P:P:T73 11.39194.42YesNo067
102P:P:I130 P:P:L305 15.40664.28NoYes086
103R:R:I130 R:R:L305 44.73434.28NoYes086
104R:R:I130 R:R:Y76 25.93384.84NoNo087
105R:R:D133 R:R:Y76 24.675111.49NoNo087
106R:R:I126 R:R:I130 18.37212.94NoNo078
107R:R:D133 R:R:R134 20.26473.57NoNo089
108R:R:I138 R:R:R134 19.6342.51NoNo089
109R:R:W283 S:S:F40 1003.01YesYes065
110S:S:F36 S:S:F40 98.720615NoYes045
111S:S:F36 S:S:N33 98.34328.46NoNo046
112S:S:N33 S:S:N37 98.22045.45NoNo063
113S:S:L41 S:S:N37 98.12364.12YesNo063
114S:S:L41 S:S:Y45 97.64629.38YesYes067
115S:S:L91 S:S:Y45 17.38893.52NoYes087
116S:S:L91 S:S:V88 17.15952.98NoNo086
117S:S:I53 S:S:V88 16.93363.07NoNo056
118S:S:I53 S:S:L85 16.62191.43NoNo057
119S:S:I60 S:S:L85 16.52961.43NoNo077
120S:S:I60 S:S:S81 16.44313.1NoNo079
121S:S:S81 S:S:V59 33.06056.46NoNo098
122S:S:R77 S:S:V59 32.78063.92NoNo088
123S:S:L305 S:S:R77 32.50253.64YesNo068
124S:S:L305 S:S:T73 11.27124.42YesNo067
125S:S:D74 S:S:T73 10.98912.89YesNo087
126S:S:F292 S:S:Y45 80.37536.19NoYes077
127S:S:F292 S:S:F87 80.278713.93NoYes077
128S:S:C295 S:S:F87 20.63084.19NoYes097
129S:S:C295 S:S:D84 20.40836.22NoYes099
130S:S:D84 S:S:N56 16.96296.73YesNo099
131S:S:N56 S:S:S81 16.99382.98NoNo099
132S:S:F87 S:S:Y116 60.16914.13YesNo076
133S:S:E288 S:S:Y116 56.9663.37NoNo056
134S:S:E288 S:S:Y255 56.852514.59NoNo057
135S:S:I259 S:S:Y255 56.740512.09NoNo057
136S:S:I259 S:S:Q200 59.28566.86NoNo055
137S:S:Q200 S:S:V196 58.26414.3NoNo054
138S:S:V196 S:S:Y190 58.02226.31NoYes044
139S:S:R188 S:S:Y190 56.47639.26NoYes054
140S:S:H113 S:S:R188 55.65283.39YesNo1365
141S:S:H113 S:S:W94 55.98316.35YesNo1367
142S:S:V112 S:S:W94 55.35544.9NoNo1357
143S:S:F93 S:S:V112 61.7945.24NoNo065
144S:S:F104 S:S:F93 61.750812.86YesNo076
145S:S:F104 S:S:W102 61.622212.03YesYes079
146S:S:D97 S:S:W102 61.36224.47NoYes059
147S:S:D97 S:S:R183 61.31883.57NoNo053
148J:J:Y111 S:S:R183 61.19063.09YesNo003
149J:J:Y111 M:M:Y37 14.82543.97YesYes200
150M:M:Y31 M:M:Y37 12.72612.98YesYes200
151J:J:Y109 M:M:Y31 28.84136.95NoYes200
152J:J:Y109 M:M:W99 20.86976.75NoYes200
153J:J:W47 M:M:W99 15.78155.62YesYes000
154J:J:H110 J:J:Y111 34.391811.98YesYes200
155J:J:H110 M:M:Y31 18.78167.62YesYes200
156J:J:Y111 S:S:D181 32.51835.75YesNo202
157M:M:R51 S:S:D181 31.52755.96YesNo202
158M:M:F41 M:M:R51 20.96045.34YesYes200
159M:M:F103 M:M:F41 19.34374.29YesYes200
160J:J:I45 M:M:F103 14.713316.33YesYes000
161J:J:I45 M:M:Y92 14.25098.46YesYes000
162M:M:G106 M:M:Y92 11.00215.79NoYes000
163M:M:G106 M:M:Q6 10.35363.29NoYes000
164J:J:D114 M:M:R51 10.87668.34NoYes000
165J:J:D114 J:J:R98 10.67445.96NoYes000
166J:J:M48 J:J:V64 10.48183.04YesNo000
167J:J:G49 J:J:M48 13.84963.49NoYes000
168J:J:G49 J:J:W47 14.18948.44NoYes000
169J:J:H110 J:J:Y108 28.49116.53YesYes000
170J:J:Y108 S:S:R30 27.94596.17YesNo005
171S:S:H281 S:S:R30 27.85510.16NoNo045
172S:S:I130 S:S:L305 28.97674.28NoYes086
173S:S:I130 S:S:Y76 16.83434.84NoNo087
174S:S:D133 S:S:Y76 16.019511.49NoNo087
175S:S:I126 S:S:I130 11.93582.94NoNo078
176S:S:D133 S:S:R134 13.16273.57NoNo089
177S:S:I138 S:S:R134 12.75392.51NoNo089
178S:S:D262 S:S:H281 27.49097.56NoNo054
179S:S:D262 S:S:I284 27.44.2NoNo054
180S:S:I284 S:S:V280 27.00713.07NoNo045
181P:P:I39 S:S:V280 26.76913.07YesNo955
182P:P:I39 S:S:W283 26.373910.57YesYes956
183P:P:F40 S:S:W283 25.76843.01YesYes056
184U:U:Y31 Y:Y:H110 17.00717.62YesYes300
185U:U:Y31 Y:Y:Y109 19.69666.95YesNo300
186U:U:W99 Y:Y:Y109 14.33296.75YesNo300
187U:U:W99 Y:Y:W47 10.98325.62YesYes000
188P:P:D181 Y:Y:Y111 28.45725.75NoYes320
189P:P:D181 U:U:R51 27.57765.96NoYes320
190U:U:F41 U:U:R51 18.36375.34YesYes300
191U:U:F103 U:U:F41 17.20834.29YesYes300
192U:U:F103 Y:Y:I45 13.13416.33YesYes000
193U:U:Y92 Y:Y:I45 12.76068.46YesYes000
194P:P:F36 P:P:F40 25.690915NoYes045
195P:P:F36 P:P:N33 25.67368.46NoNo046
196P:P:N33 P:P:N37 25.68425.45NoNo063
197P:P:L41 P:P:N37 25.69644.12YesNo063
198P:P:L41 P:P:Y45 25.76159.38YesYes067
199P:P:F292 P:P:Y45 21.16146.19NoYes077
200P:P:F292 P:P:F87 21.16713.93NoYes077
201P:P:I259 P:P:Y255 15.354712.09NoNo057
202P:P:E288 P:P:Y255 15.290414.59NoNo057
203P:P:E288 P:P:Y116 15.22873.37NoNo056
204P:P:F87 P:P:Y116 16.01834.13YesNo076
205L:L:F103 L:L:F41 13.13534.29YesYes100
206N:N:Y111 R:R:D181 21.77315.75YesNo102
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
P:P:E31 U:U:T32 4.23 0 No No 5 0 1 0
P:P:D181 U:U:R51 5.96 3 No Yes 2 0 1 0
P:P:D181 U:U:Y54 4.6 3 No Yes 2 0 1 0
P:P:D182 U:U:Y54 16.09 0 No Yes 6 0 1 0
P:P:F29 U:U:W99 6.01 3 Yes Yes 4 0 1 0
P:P:F189 Y:Y:S31 9.25 0 Yes No 3 0 1 0
P:P:S178 Y:Y:Y32 6.36 6 No Yes 1 0 1 0
P:P:P27 Y:Y:W50 4.05 3 Yes Yes 5 0 1 0
P:P:F29 Y:Y:W50 7.02 3 Yes Yes 4 0 1 0
P:P:D193 Y:Y:N55 6.73 0 No Yes 1 0 1 0
P:P:P27 Y:Y:N57 4.89 3 Yes No 5 0 1 0
P:P:M24 Y:Y:R58 4.96 0 No No 2 0 1 0
P:P:E26 Y:Y:N59 3.94 3 No No 2 0 1 0
P:P:P27 Y:Y:N59 8.15 3 Yes No 5 0 1 0
P:P:N192 Y:Y:R74 3.62 0 No No 1 0 1 0
P:P:S178 Y:Y:I101 4.64 6 No No 1 0 1 0
P:P:F189 Y:Y:G103 3.01 0 Yes No 3 0 1 0
P:P:D187 Y:Y:R105 4.76 0 No No 3 0 1 0
P:P:I185 Y:Y:N106 5.66 0 No No 3 0 1 0
P:P:D187 Y:Y:N106 12.12 0 No No 3 0 1 0
P:P:F29 Y:Y:Y107 7.22 3 Yes Yes 4 0 1 0
P:P:R30 Y:Y:Y108 5.14 0 No Yes 5 0 1 0
P:P:E32 Y:Y:Y108 10.1 0 No Yes 4 0 1 0
P:P:F29 Y:Y:Y109 17.54 3 Yes No 4 0 1 0
P:P:D181 Y:Y:Y111 5.75 3 No Yes 2 0 1 0
P:P:R183 Y:Y:Y111 3.09 0 No Yes 3 0 1 0
P:P:E26 P:P:P27 3.14 3 No Yes 2 5 1 1
P:P:H281 P:P:R30 10.16 0 No No 4 5 2 1
P:P:D97 P:P:R183 3.57 0 No No 5 3 2 1
P:P:N101 P:P:R183 14.46 0 No No 4 3 2 1
P:P:F174 P:P:Y190 8.25 0 No Yes 4 4 2 2
P:P:F189 P:P:N176 6.04 0 Yes No 3 4 1 2
P:P:F189 P:P:S178 5.28 0 Yes No 3 1 1 1
P:P:V196 P:P:Y190 6.31 0 No Yes 4 4 1 2
P:P:P191 P:P:W195 8.11 0 No No 5 5 1 2
P:P:D193 P:P:L266 8.14 0 No No 1 3 1 2
P:P:Q200 P:P:V196 4.3 0 No No 5 4 2 1
P:P:F174 P:P:P191 2.89 0 No No 4 5 2 1
P:P:W195 P:P:Y190 2.89 0 No Yes 5 4 2 2
P:P:A180 Y:Y:Y111 2.67 0 No Yes 1 0 1 0
P:P:P191 Y:Y:T30 1.75 0 No No 5 0 1 0
P:P:V196 Y:Y:A104 1.7 0 No No 4 0 1 0
P:P:A34 U:U:D33 1.54 0 No Yes 1 0 1 0
P:P:K25 Y:Y:N57 1.4 0 No No 4 0 1 0
P:P:E31 P:P:N278 1.31 0 No No 5 3 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
M:M:T32 S:S:E31 4.23 0 No No 0 5 0 1
M:M:R51 S:S:D181 5.96 2 Yes No 0 2 0 1
M:M:Y54 S:S:D181 4.6 2 Yes No 0 2 0 1
M:M:Y54 S:S:D182 16.09 2 Yes No 0 6 0 1
M:M:W99 S:S:F29 6.01 2 Yes Yes 0 4 0 1
J:J:S31 S:S:F189 9.25 0 No Yes 0 3 0 1
J:J:Y32 S:S:S178 6.36 5 Yes No 0 1 0 1
J:J:W50 S:S:P27 4.05 2 Yes Yes 0 5 0 1
J:J:W50 S:S:F29 7.02 2 Yes Yes 0 4 0 1
J:J:N55 S:S:D193 6.73 2 Yes No 0 1 0 1
J:J:N57 S:S:P27 4.89 0 No Yes 0 5 0 1
J:J:R58 S:S:M24 4.96 0 No No 0 2 0 1
J:J:N59 S:S:E26 3.94 2 No No 0 2 0 1
J:J:N59 S:S:P27 8.15 2 No Yes 0 5 0 1
J:J:R74 S:S:N192 3.62 0 No No 0 1 0 1
J:J:I101 S:S:S178 4.64 5 No No 0 1 0 1
J:J:G103 S:S:F189 3.01 0 No Yes 0 3 0 1
J:J:R105 S:S:D187 4.76 0 No No 0 3 0 1
J:J:N106 S:S:I185 5.66 0 No No 0 3 0 1
J:J:N106 S:S:D187 12.12 0 No No 0 3 0 1
J:J:Y107 S:S:F29 7.22 2 Yes Yes 0 4 0 1
J:J:Y108 S:S:R30 6.17 0 Yes No 0 5 0 1
J:J:Y108 S:S:E32 10.1 0 Yes No 0 4 0 1
J:J:Y109 S:S:F29 17.54 2 No Yes 0 4 0 1
J:J:Y111 S:S:D181 5.75 2 Yes No 0 2 0 1
J:J:Y111 S:S:R183 3.09 2 Yes No 0 3 0 1
S:S:E26 S:S:P27 3.14 2 No Yes 2 5 1 1
S:S:H281 S:S:R30 10.16 0 No No 4 5 2 1
S:S:D97 S:S:R183 3.57 0 No No 5 3 2 1
S:S:N101 S:S:R183 14.46 0 No No 4 3 2 1
S:S:F174 S:S:Y190 8.25 0 No Yes 4 4 2 2
S:S:F189 S:S:N176 6.04 0 Yes No 3 4 1 2
S:S:F189 S:S:S178 5.28 0 Yes No 3 1 1 1
S:S:V196 S:S:Y190 6.31 0 No Yes 4 4 1 2
S:S:P191 S:S:W195 8.11 0 No No 5 5 1 2
S:S:D193 S:S:L266 8.14 0 No No 1 3 1 2
S:S:Q200 S:S:V196 4.3 0 No No 5 4 2 1
S:S:F174 S:S:P191 2.89 0 No No 4 5 2 1
S:S:W195 S:S:Y190 2.89 0 No Yes 5 4 2 2
J:J:Y111 S:S:A180 2.67 2 Yes No 0 1 0 1
J:J:T30 S:S:P191 1.75 0 No No 0 5 0 1
J:J:A104 S:S:V196 1.7 0 No No 0 4 0 1
M:M:D33 S:S:A34 1.54 0 Yes No 0 1 0 1
J:J:N57 S:S:K25 1.4 0 No No 0 4 0 1
S:S:E31 S:S:N278 1.31 0 No No 5 3 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:T32 R:R:E31 4.23 0 No No 0 5 0 1
L:L:R51 R:R:D181 5.96 1 Yes No 0 2 0 1
L:L:Y54 R:R:D181 4.6 1 Yes No 0 2 0 1
L:L:Y54 R:R:D182 16.09 1 Yes No 0 6 0 1
L:L:W99 R:R:F29 6.01 1 Yes Yes 0 4 0 1
N:N:S31 R:R:F189 9.25 0 No Yes 0 3 0 1
N:N:Y32 R:R:S178 6.36 4 Yes No 0 1 0 1
N:N:W50 R:R:P27 4.05 1 Yes Yes 0 5 0 1
N:N:W50 R:R:F29 7.02 1 Yes Yes 0 4 0 1
N:N:N55 R:R:D193 6.73 1 Yes No 0 1 0 1
N:N:N57 R:R:P27 4.89 0 No Yes 0 5 0 1
N:N:N59 R:R:E26 3.94 1 No No 0 2 0 1
N:N:N59 R:R:P27 8.15 1 No Yes 0 5 0 1
N:N:R74 R:R:N192 3.62 0 No No 0 1 0 1
N:N:I101 R:R:S178 4.64 4 No No 0 1 0 1
N:N:G103 R:R:F189 3.01 0 No Yes 0 3 0 1
N:N:R105 R:R:D187 4.76 0 No No 0 3 0 1
N:N:N106 R:R:I185 5.66 0 No No 0 3 0 1
N:N:N106 R:R:D187 12.12 0 No No 0 3 0 1
N:N:Y107 R:R:F29 7.22 1 Yes Yes 0 4 0 1
N:N:Y108 R:R:R30 5.14 0 Yes No 0 5 0 1
N:N:Y108 R:R:E32 10.1 0 Yes No 0 4 0 1
N:N:Y109 R:R:F29 17.54 1 No Yes 0 4 0 1
N:N:Y111 R:R:D181 5.75 1 Yes No 0 2 0 1
N:N:Y111 R:R:R183 3.09 1 Yes No 0 3 0 1
R:R:E26 R:R:P27 3.14 1 No Yes 2 5 1 1
R:R:H281 R:R:R30 10.16 0 No No 4 5 2 1
R:R:D97 R:R:R183 3.57 0 No No 5 3 2 1
R:R:N101 R:R:R183 14.46 0 No No 4 3 2 1
R:R:F174 R:R:Y190 8.25 0 No Yes 4 4 2 2
R:R:F189 R:R:N176 6.04 0 Yes No 3 4 1 2
R:R:F189 R:R:S178 5.28 0 Yes No 3 1 1 1
R:R:V196 R:R:Y190 6.31 0 No Yes 4 4 1 2
R:R:P191 R:R:W195 8.11 0 No No 5 5 1 2
R:R:D193 R:R:L266 8.14 0 No No 1 3 1 2
R:R:Q200 R:R:V196 4.3 0 No No 5 4 2 1
R:R:F174 R:R:P191 2.89 0 No No 4 5 2 1
R:R:W195 R:R:Y190 2.89 0 No Yes 5 4 2 2
N:N:Y111 R:R:A180 2.67 1 Yes No 0 1 0 1
N:N:T30 R:R:P191 1.75 0 No No 0 5 0 1
N:N:A104 R:R:V196 1.7 0 No No 0 4 0 1
L:L:D33 R:R:A34 1.54 0 Yes No 0 1 0 1
N:N:N57 R:R:K25 1.4 0 No No 0 4 0 1
R:R:E31 R:R:N278 1.31 0 No No 5 3 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8U4S_poly
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.98
Number of Linked Nodes 1458
Number of Links 1639
Number of Hubs 222
Number of Links mediated by Hubs 822
Number of Communities 42
Number of Nodes involved in Communities 267
Number of Links involved in Communities 345
Path Summary
Number Of Nodes in MetaPath 207
Number Of Links MetaPath 206
Number of Shortest Paths 2559384
Length Of Smallest Path 3
Average Path Length 41.1648
Length of Longest Path 85
Minimum Path Strength 1.43
Average Path Strength 6.35744
Maximum Path Strength 16.46
Minimum Path Correlation 0.71
Average Path Correlation 0.992649
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 4.7619
Average % Of Corr. Nodes 44.021
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 39.2181
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP61073
Sequence
>8U4S_poly_Chain_R
MKEPCFREE NANFNKIFL PTIYSIIFL TGIVGNGLV ILVMGYQKK 
LRSMTDKYR LHLSVADLL FVITLPFWA VDAVANWYF GNFLCKAVH 
VIYTVLYSS VLILAFISL DRYLAIVHA TNSQRPRKL LAEKVVYVG 
VWIPALLLT IPDFIFANV SEADDRYIC DRFYPNDLW VVVFQFQHI 
MVGLILPGI VILSCYCII ISKLSHSKG HQKRKALKT TVILILAFF 
ACWLPYYIG ISIDSFILL EIIKQGCEF ENTVHKWIS ITEALAFFH 
CCLNPILYA FLGAS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YU7AProteinChemokineCXCR4Homo sapiens---3.012025-03-05doi.org/10.1016/j.celrep.2025.115255
8U4NAProteinChemokineCXCR4Homo sapiens--Gi1/β1/γ22.722024-03-13doi.org/10.1101/2024.02.09.579708
8U4N (No Gprot) AProteinChemokineCXCR4Homo sapiens--2.722024-03-13doi.org/10.1101/2024.02.09.579708
8U4OAProteinChemokineCXCR4Homo sapiensCXCL12-Gi1/β1/γ23.292024-03-13doi.org/10.1101/2024.02.09.579708
8U4O (No Gprot) AProteinChemokineCXCR4Homo sapiensCXCL12-3.292024-03-13doi.org/10.1101/2024.02.09.579708
8U4PAProteinChemokineCXCR4Homo sapiensAMD3100-Gi1/β1/γ23.152024-03-13doi.org/10.1101/2024.02.09.579708
8U4P (No Gprot) AProteinChemokineCXCR4Homo sapiensAMD3100-3.152024-03-13doi.org/10.1101/2024.02.09.579708
8U4QAProteinChemokineCXCR4Homo sapiensREGN7663-Fab-Gi1/β1/γ23.362024-03-13doi.org/10.1101/2024.02.09.579708
8U4Q (No Gprot) AProteinChemokineCXCR4Homo sapiensREGN7663-Fab-3.362024-03-13doi.org/10.1101/2024.02.09.579708
8U4RAProteinChemokineCXCR4Homo sapiensREGN7663-Fab--3.12024-03-13doi.org/10.1101/2024.02.09.579708
3ODUAProteinChemokineCXCR4Homo sapiensIT1t--2.52010-10-27doi.org/10.1126/science.1194396
3OE0AProteinChemokineCXCR4Homo sapiensCVX15--2.92010-10-27doi.org/10.1126/science.1194396
3OE6AProteinChemokineCXCR4Homo sapiensIT1t--3.22010-10-27doi.org/10.1126/science.1194396
3OE8AProteinChemokineCXCR4Homo sapiensIT1t--3.12010-10-27doi.org/10.1126/science.1194396
3OE9AProteinChemokineCXCR4Homo sapiensIT1t--3.12010-10-27doi.org/10.1126/science.1194396
4RWSAProteinChemokineCXCR4Homo sapiensvMIP-II--3.12015-02-11doi.org/10.1126/science.1261064
8K3ZAProteinChemokineCXCR4Homo sapiensCXCL12-Gi1/β1/γ12.812024-07-17doi.org/10.1016/j.celrep.2024.114578
8K3Z (No Gprot) AProteinChemokineCXCR4Homo sapiensCXCL12-2.812024-07-17doi.org/10.1016/j.celrep.2024.114578
8U4SAProteinChemokineCXCR4Homo sapiensREGN7663-Fab--3.352024-03-13doi.org/10.1038/s41594-024-01397-1
8U4TAProteinChemokineCXCR4Homo sapiensREGN7663-Fab--3.382024-03-13doi.org/10.1038/s41594-024-01397-1
8ZPLAProteinChemokineCXCR4Homo sapiensHF51116--3.012025-02-26doi.org/10.1073/pnas.2425795122
8ZPMAProteinChemokineCXCR4Homo sapiensAMD070--3.22025-02-26doi.org/10.1073/pnas.2425795122
8ZPNAProteinChemokineCXCR4Homo sapiensAMD3100--3.312025-02-26doi.org/10.1073/pnas.2425795122




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8U4S_poly.zip



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