Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1C:C:K38 6.08404
2C:C:Y45 3.99333697
3C:C:I48 4.955407
4C:C:N56 4.41409
5C:C:M63 3.815196
6C:C:Y76 4.236507
7C:C:D84 4.984509
8C:C:F87 8.0575497
9C:C:L91 3.36498
10C:C:W94 4.0075497
11C:C:W102 9.025419
12C:C:H113 4.29516
13C:C:Y116 4.6475496
14C:C:I126 3.494507
15C:C:F129 4.5654205
16C:C:D133 6408
17C:C:Y135 6.056138
18C:C:V160 4.025407
19C:C:Y190 8.424514
20C:C:W195 5.3525415
21C:C:H203 4.864554
22C:C:I215 3.73754227
23C:C:I222 2.9925138
24C:C:T241 3.39407
25C:C:F248 7.872559
26C:C:W252 8.936559
27C:C:Y255 5.89167657
28C:C:Y256 5.575658
29C:C:I257 4.685406
30C:C:I259 5.252555
31C:C:I270 3.3685245
32C:C:W283 5.2525406
33C:C:F292 6.745497
34C:C:H294 9.0425459
35P:P:K38 6.08404
36P:P:Y45 3.993336107
37P:P:I48 4.955407
38P:P:N56 4.41409
39P:P:M63 3.5225156
40P:P:K68 4.44254156
41P:P:Y76 4.236507
42P:P:D84 4.984509
43P:P:F87 8.05754107
44P:P:L91 3.364108
45P:P:W94 4.00754107
46P:P:W102 9.025429
47P:P:H113 4.29526
48P:P:Y116 4.64754106
49P:P:I126 3.494507
50P:P:F129 4.5654255
51P:P:D133 6408
52P:P:Y135 6.056168
53P:P:V160 4.025407
54P:P:Y190 8.424524
55P:P:W195 5.3525425
56P:P:H203 4.864564
57P:P:I215 3.73754277
58P:P:I222 2.9925168
59P:P:T241 3.39407
60P:P:F248 7.872569
61P:P:W252 8.936569
62P:P:Y255 5.89167667
63P:P:Y256 5.575668
64P:P:I257 4.685406
65P:P:I259 5.252565
66P:P:I270 3.3685215
67P:P:W283 5.2525406
68P:P:F292 6.7454107
69P:P:H294 9.0425469
70R:R:K38 6.08404
71R:R:Y45 3.993336117
72R:R:I48 4.955407
73R:R:N56 4.41409
74R:R:M63 3.5225146
75R:R:K68 5.08254146
76R:R:Y76 4.236507
77R:R:D84 4.984509
78R:R:F87 8.05754117
79R:R:L91 3.364118
80R:R:W94 4.00754117
81R:R:W102 9.025439
82R:R:H113 4.29536
83R:R:Y116 4.64754116
84R:R:I126 3.494507
85R:R:F129 4.5654295
86R:R:D133 6408
87R:R:Y135 6.056178
88R:R:V160 4.025407
89R:R:Y190 8.424534
90R:R:W195 5.3525435
91R:R:H203 4.864574
92R:R:I215 3.73754307
93R:R:I222 2.9925178
94R:R:T241 3.39407
95R:R:F248 7.872579
96R:R:W252 8.936579
97R:R:Y255 5.89167677
98R:R:Y256 5.575678
99R:R:I257 4.685406
100R:R:I259 5.252575
101R:R:I270 3.3685325
102R:R:W283 5.2525406
103R:R:F292 6.7454117
104R:R:H294 9.0425479
105S:S:K38 6.08404
106S:S:Y45 3.993336127
107S:S:I48 4.955407
108S:S:N56 4.41409
109S:S:M63 3.5225336
110S:S:Y76 4.236507
111S:S:D84 4.984509
112S:S:F87 8.05754127
113S:S:L91 3.364128
114S:S:W94 4.00754127
115S:S:W102 9.025449
116S:S:H113 4.29546
117S:S:Y116 4.64754126
118S:S:I126 3.494507
119S:S:F129 4.5654345
120S:S:D133 6408
121S:S:Y135 6.056188
122S:S:V160 4.025407
123S:S:Y190 8.424544
124S:S:W195 5.3525445
125S:S:H203 4.864584
126S:S:I215 3.73754357
127S:S:I222 2.9925188
128S:S:T241 3.39407
129S:S:F248 7.872589
130S:S:W252 8.936589
131S:S:Y255 5.89167687
132S:S:Y256 5.575688
133S:S:I257 4.685406
134S:S:I259 5.252585
135S:S:I270 3.3685265
136S:S:W283 5.2525406
137S:S:F292 6.7454127
138S:S:H294 9.0425489
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1C:C:E288 C:C:Y116 65.40564.49NoYes056
2C:C:F292 C:C:Y116 43.77473.09YesYes976
3C:C:F292 C:C:I48 62.4143.77YesYes077
4C:C:F293 C:C:I48 98.98955.02NoYes057
5C:C:F293 C:C:I44 98.82796.28NoNo055
6C:C:F40 C:C:I44 98.666211.3NoNo055
7C:C:F36 C:C:F40 98.58547.5NoNo045
8C:C:F36 P:P:W283 98.50453.01NoYes046
9C:C:I39 P:P:W283 13.16735.87NoYes056
10C:C:I39 P:P:F276 12.16198.79NoNo051
11C:C:K38 P:P:F276 11.66253.72YesNo041
12C:C:W94 C:C:Y116 23.09864.82YesYes976
13C:C:F87 C:C:L91 21.93593.65YesYes978
14C:C:L91 C:C:W94 21.19753.42YesYes987
15C:C:F87 C:C:N119 44.16598.46YesNo078
16C:C:D84 C:C:N119 42.81625.39YesNo098
17C:C:D84 C:C:N56 20.9375.39YesYes099
18C:C:N56 C:C:S81 16.51482.98YesNo099
19C:C:S81 C:C:V59 15.7714.85NoNo098
20C:C:V59 C:C:Y302 15.02655.05NoNo089
21C:C:M63 C:C:Y302 11.29335.99YesNo069
22P:P:T287 P:P:W283 89.91533.64NoYes066
23P:P:T287 P:P:Y255 89.75074.99NoYes067
24P:P:W252 P:P:Y255 34.86936.75YesYes697
25P:P:H294 P:P:W252 30.537413.75YesYes699
26P:P:C295 P:P:H294 30.32664.42NoYes099
27P:P:C295 P:P:D84 30.40574.67NoYes099
28P:P:D84 P:P:L80 47.72565.43YesNo099
29P:P:I126 P:P:L80 47.01435.71YesNo079
30P:P:I126 P:P:I130 38.23852.94YesNo078
31P:P:I130 P:P:Y76 36.80294.84NoYes087
32P:P:D133 P:P:Y76 32.65285.75YesYes087
33P:P:D133 P:P:R134 26.80383.57YesNo089
34P:P:R134 P:P:T241 25.38912.59NoYes097
35P:P:T241 P:P:Y219 22.44446.24YesNo078
36P:P:I222 P:P:Y219 17.98612.42YesNo088
37C:C:D84 C:C:L80 45.03925.43YesNo099
38C:C:I126 C:C:L80 44.32255.71YesNo079
39C:C:I126 C:C:I130 35.49622.94YesNo078
40C:C:I130 C:C:Y76 34.04984.84NoYes087
41C:C:D133 C:C:Y76 29.85145.75YesYes087
42C:C:T287 C:C:W283 89.43643.64NoYes066
43C:C:T287 C:C:Y255 89.26544.99NoYes067
44C:C:W252 C:C:Y255 33.19096.75YesYes597
45C:C:H294 C:C:W252 28.787513.75YesYes599
46C:C:C295 C:C:H294 28.54684.42NoYes099
47C:C:E288 C:C:Y255 59.42015.61NoYes057
48C:C:V112 C:C:W94 42.80214.9NoYes057
49C:C:F93 C:C:V112 41.34172.62NoNo065
50C:C:F104 C:C:F93 40.36444.29NoNo076
51C:C:F104 C:C:W102 39.384315.03NoYes079
52C:C:C109 C:C:W102 19.20043.92NoYes199
53C:C:C186 C:C:W102 19.200410.45NoYes199
54C:C:C109 C:C:H113 18.69452.95NoYes196
55C:C:C186 C:C:H113 18.69454.42NoYes196
56C:C:H113 C:C:R188 23.93733.39YesNo165
57C:C:D133 C:C:R134 23.96043.57YesNo089
58C:C:R134 C:C:T241 22.52922.59NoYes097
59C:C:T241 C:C:Y219 19.56286.24YesNo078
60C:C:I222 C:C:Y219 15.07632.42YesNo088
61C:C:R188 C:C:Y190 22.960112.35NoYes154
62C:C:W283 R:R:F36 98.16353.01YesNo064
63R:R:F36 R:R:F40 98.24767.5NoNo045
64R:R:F40 R:R:I44 98.331711.3NoNo055
65R:R:F293 R:R:I44 98.49986.28NoNo055
66R:R:F293 R:R:I48 98.6685.02NoYes057
67R:R:I48 R:R:L91 37.95012.85YesYes078
68R:R:F87 R:R:L91 22.45843.65YesYes1178
69R:R:F87 R:R:N119 45.23598.46YesNo078
70R:R:D84 R:R:N119 43.89275.39YesNo098
71R:R:D84 R:R:N56 23.19175.39YesYes099
72R:R:F292 R:R:I48 61.80413.77YesYes077
73R:R:F292 R:R:F87 19.17313.93YesYes1177
74R:R:N56 R:R:S81 18.77242.98YesNo099
75R:R:S81 R:R:V59 18.0294.85NoNo098
76R:R:V59 R:R:Y302 17.28495.05NoNo089
77R:R:M63 R:R:Y302 13.55345.99YesNo069
78C:C:F276 R:R:K38 11.69493.72NoYes014
79C:C:W283 R:R:I39 13.2035.87YesNo065
80C:C:F276 R:R:I39 12.19558.79NoNo015
81P:P:E288 P:P:Y255 58.22855.61NoYes057
82P:P:E288 P:P:Y116 64.21514.49NoYes056
83P:P:F292 P:P:Y116 42.73833.09YesYes1076
84P:P:F292 P:P:I48 62.49483.77YesYes077
85P:P:F293 P:P:I48 1005.02NoYes057
86P:P:F293 P:P:I44 99.82976.28NoNo055
87P:P:F40 P:P:I44 99.659311.3NoNo055
88P:P:F36 P:P:F40 99.57427.5NoNo045
89P:P:F36 S:S:W283 99.4893.01NoYes046
90P:P:I39 S:S:W283 13.21495.87NoYes056
91P:P:I39 S:S:F276 12.20678.79NoNo051
92P:P:K38 S:S:F276 11.70583.72YesNo041
93P:P:W94 P:P:Y116 23.11814.82YesYes1076
94P:P:F87 P:P:L91 23.27223.65YesYes1078
95P:P:L91 P:P:W94 21.28633.42YesYes1087
96P:P:D84 P:P:N56 23.05865.39YesYes099
97P:P:N56 P:P:S81 18.66492.98YesNo099
98P:P:S81 P:P:V59 17.92584.85NoNo098
99P:P:V59 P:P:Y302 17.1863.79NoNo089
100P:P:M63 P:P:Y302 13.47625.99YesNo069
101P:P:F87 P:P:N119 46.89458.46YesNo078
102P:P:V112 P:P:W94 42.92194.9NoYes057
103P:P:F93 P:P:V112 41.45712.62NoNo065
104P:P:F104 P:P:F93 40.4774.29NoNo076
105P:P:F104 P:P:W102 39.49415.03NoYes079
106R:R:F292 R:R:Y116 42.7443.09YesYes1176
107R:R:E288 R:R:Y116 64.39954.49NoYes056
108R:R:E288 R:R:Y255 58.49525.61NoYes057
109R:R:T287 R:R:Y255 89.58914.99NoYes067
110R:R:T287 R:R:W283 89.76883.64NoYes066
111R:R:W283 S:S:F36 98.68063.01YesNo064
112S:S:F36 S:S:F40 98.76917.5NoNo045
113S:S:F40 S:S:I44 98.857511.3NoNo055
114S:S:F293 S:S:I44 99.03436.28NoNo055
115S:S:F293 S:S:I48 99.21115.02NoYes057
116S:S:F292 S:S:I48 62.67273.77YesYes077
117S:S:F292 S:S:Y116 43.77583.09YesYes1276
118S:S:E288 S:S:Y116 65.6994.49NoYes056
119P:P:C109 P:P:W102 19.25393.92NoYes299
120P:P:C186 P:P:W102 19.253910.45NoYes299
121P:P:C109 P:P:H113 18.74652.95NoYes296
122P:P:C186 P:P:H113 18.74654.42NoYes296
123P:P:H113 P:P:R188 24.00373.39YesNo265
124P:P:R188 P:P:Y190 23.023612.35NoYes254
125R:R:L91 R:R:W94 21.19753.42YesYes1187
126R:R:D84 R:R:L80 45.14935.43YesNo099
127R:R:I126 R:R:L80 44.43085.71YesNo079
128R:R:I126 R:R:I130 35.58282.94YesNo078
129R:R:I130 R:R:Y76 34.13284.84NoYes087
130R:R:D133 R:R:Y76 29.92355.75YesYes087
131R:R:C295 R:R:D84 29.7424.67NoYes099
132R:R:V112 R:R:W94 42.8924.9NoYes057
133R:R:F93 R:R:V112 41.42832.62NoNo065
134R:R:F104 R:R:F93 40.44894.29NoNo076
135R:R:F104 R:R:W102 39.466615.03NoYes079
136R:R:C109 R:R:W102 19.24053.92NoYes399
137R:R:C186 R:R:W102 19.240510.45NoYes399
138R:R:C109 R:R:H113 18.73352.95NoYes396
139R:R:C186 R:R:H113 18.73354.42NoYes396
140R:R:H113 R:R:R188 23.98713.39YesNo365
141R:R:W252 R:R:Y255 34.30856.75YesYes797
142R:R:D133 R:R:R134 24.01813.57YesNo089
143R:R:R134 R:R:T241 22.58332.59NoYes097
144R:R:T241 R:R:Y219 19.60976.24YesNo078
145R:R:I222 R:R:Y219 15.11242.42YesNo088
146R:R:R188 R:R:Y190 23.007712.35NoYes354
147S:S:I48 S:S:L91 37.68022.85YesYes078
148S:S:F87 S:S:L91 22.31993.65YesYes1278
149S:S:F87 S:S:N119 44.96168.46YesNo078
150S:S:D84 S:S:N119 43.61845.39YesNo098
151S:S:D84 S:S:N56 23.03735.39YesYes099
152S:S:F292 S:S:F87 19.031613.93YesYes1277
153S:S:N56 S:S:S81 18.64762.98YesNo099
154S:S:S81 S:S:V59 17.90924.85NoNo098
155S:S:V59 S:S:Y302 17.17015.05NoNo089
156S:S:M63 S:S:Y302 13.46395.99YesNo069
157R:R:C295 R:R:H294 29.67164.42NoYes099
158R:R:H294 R:R:W252 29.916713.75YesYes799
159R:R:W283 S:S:I39 13.25075.87YesNo065
160R:R:F276 S:S:I39 12.24028.79NoNo015
161R:R:F276 S:S:K38 11.73823.72NoYes014
162S:S:L91 S:S:W94 21.07923.42YesYes1287
163S:S:D84 S:S:L80 44.84115.43YesNo099
164S:S:I126 S:S:L80 44.12765.71YesNo079
165S:S:I126 S:S:I130 35.34032.94YesNo078
166S:S:I130 S:S:Y76 33.90044.84NoYes087
167S:S:D133 S:S:Y76 29.72145.75YesYes087
168S:S:C295 S:S:D84 29.54144.67NoYes099
169S:S:V112 S:S:W94 43.01184.9NoYes057
170S:S:F93 S:S:V112 41.54382.62NoNo065
171S:S:F104 S:S:F93 40.56154.29NoNo076
172S:S:F104 S:S:W102 39.576315.03NoYes079
173S:S:C109 S:S:W102 19.29393.92NoYes499
174S:S:C186 S:S:W102 19.293910.45NoYes499
175S:S:C109 S:S:H113 18.78542.95NoYes496
176S:S:C186 S:S:H113 18.78544.42NoYes496
177S:S:H113 S:S:R188 24.05353.39YesNo465
178S:S:E288 S:S:Y255 59.74855.61NoYes057
179S:S:W252 S:S:Y255 34.0836.75YesYes897
180S:S:D133 S:S:R134 23.85653.57YesNo089
181S:S:R134 S:S:T241 22.43172.59NoYes097
182S:S:T241 S:S:Y219 19.47836.24YesNo078
183S:S:I222 S:S:Y219 15.01142.42YesNo088
184S:S:R188 S:S:Y190 23.071212.35NoYes454
185S:S:C295 S:S:H294 29.46674.42NoYes099
186S:S:H294 S:S:W252 29.70213.75YesYes899
187S:S:T287 S:S:Y255 90.54214.99NoYes067
188S:S:T287 S:S:W283 90.71543.64NoYes066
189C:C:I48 C:C:L91 37.62032.85YesYes078
190C:C:F292 C:C:F87 18.741413.93YesYes977
191C:C:C295 C:C:D84 28.6244.67NoYes099
192S:S:W94 S:S:Y116 23.44654.82YesYes1276
193P:P:D84 P:P:N119 45.565.39YesNo098
194P:P:I48 P:P:L91 38.60552.85YesYes078
195P:P:F292 P:P:F87 19.867713.93YesYes1077
196R:R:W94 R:R:Y116 23.18964.82YesYes1176
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8YU7_poly
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.62
Number of Linked Nodes 1049
Number of Links 1159
Number of Hubs 138
Number of Links mediated by Hubs 514
Number of Communities 36
Number of Nodes involved in Communities 206
Number of Links involved in Communities 264
Path Summary
Number Of Nodes in MetaPath 197
Number Of Links MetaPath 196
Number of Shortest Paths 1016202
Length Of Smallest Path 3
Average Path Length 27.1915
Length of Longest Path 59
Minimum Path Strength 1.31
Average Path Strength 5.45667
Maximum Path Strength 12.74
Minimum Path Correlation 0.7
Average Path Correlation 0.983381
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.08333
Average % Of Corr. Nodes 51.4625
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.1921
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• molecular transducer activity   • coreceptor activity   • signaling receptor activity   • cytoskeletal protein binding   • myosin light chain binding   • protein binding   • binding   • myosin binding   • C-C chemokine binding   • chemokine binding   • cytokine binding   • G protein-coupled chemoattractant receptor activity   • C-X-C motif chemokine 12 receptor activity   • C-X-C chemokine receptor activity   • chemokine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • cytokine receptor activity   • immune receptor activity   • ubiquitin protein ligase binding   • ubiquitin-like protein ligase binding   • enzyme binding   • virus receptor activity   • exogenous protein binding   • C-C chemokine receptor activity   • ubiquitin binding   • ubiquitin-like protein binding   • actin binding   • developmental process   • multicellular organism development   • multicellular organismal process   • head development   • central nervous system development   • anatomical structure development   • animal organ development   • brain development   • nervous system development   • system development   • regulation of biological process   • cell adhesion   • regulation of cellular process   • regulation of cell adhesion
Gene OntologyBiological Process• developmental process   • multicellular organism development   • multicellular organismal process   • head development   • central nervous system development   • anatomical structure development   • animal organ development   • brain development   • nervous system development   • system development   • regulation of biological process   • cell adhesion   • regulation of cellular process   • regulation of cell adhesion   • biological regulation   • cellular process   • apoptotic process   • cell death   • programmed cell death   • membrane organization   • cellular component organization   • myelination   • myelin maintenance   • axon ensheathment   • ensheathment of neurons   • plasma membrane organization   • cellular component organization or biogenesis   • endomembrane system organization   • cell chemotaxis   • cellular response to stimulus   • chemotaxis   • dendritic cell chemotaxis   • response to stimulus   • response to external stimulus   • leukocyte migration   • dendritic cell migration   • cellular response to chemical stimulus   • taxis   • immune system process   • response to chemical   • mononuclear cell migration   • cell migration   • cell motility   • leukocyte chemotaxis   • locomotion   • response to decreased oxygen levels   • response to hypoxia   • response to stress   • response to oxygen levels   • response to abiotic stimulus   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • neurogenesis   • cellular developmental process   • cell differentiation   • regulation of response to external stimulus   • regulation of chemotaxis   • regulation of response to stimulus   • regulation of locomotion   • immune response   • cell surface receptor signaling pathway   • chemokine (C-X-C motif) ligand 12 signaling pathway   • signaling   • CXCL12-activated CXCR4 signaling pathway   • response to cytokine   • response to chemokine   • cytokine-mediated signaling pathway   • cellular response to chemokine   • chemokine-mediated signaling pathway   • cell communication   • response to peptide   • G protein-coupled receptor signaling pathway   • cellular response to cytokine stimulus   • signal transduction   • C-X-C chemokine receptor CXCR4 signaling pathway   • intracellular signal transduction   • calcium-mediated signaling   • intracellular signaling cassette   • regulation of multicellular organismal development   • regulation of developmental process   • positive regulation of biological process   • vasculature development   • regulation of vasculature development   • circulatory system development   • positive regulation of developmental process   • positive regulation of vasculature development   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • positive regulation of macrophage migration inhibitory factor signaling pathway   • positive regulation of response to cytokine stimulus   • positive regulation of response to stimulus   • macrophage migration inhibitory factor signaling pathway   • positive regulation of cellular process   • regulation of signaling   • regulation of macrophage migration inhibitory factor signaling pathway   • regulation of cytokine-mediated signaling pathway   • regulation of response to cytokine stimulus   • regulation of cell communication   • positive regulation of cytokine-mediated signaling pathway   • positive regulation of signaling   • homeostatic process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • metabolic process   • regulation of metabolic process   • positive regulation of locomotion   • regulation of cell motility   • positive regulation of cell migration   • positive regulation of cell motility   • regulation of cell migration   • biological process involved in interspecies interaction between organisms   • response to other organism   • response to external biotic stimulus   • response to virus   • response to biotic stimulus   • defense response   • inflammatory response   • positive regulation of nervous system development   • cell development   • regulation of neurogenesis   • regulation of cell differentiation   • regulation of gliogenesis   • positive regulation of gliogenesis   • regulation of cell development   • regulation of nervous system development   • gliogenesis   • positive regulation of cell differentiation   • positive regulation of neurogenesis   • positive regulation of oligodendrocyte differentiation   • positive regulation of cell development   • regulation of glial cell differentiation   • positive regulation of glial cell differentiation   • oligodendrocyte differentiation   • glial cell differentiation   • regulation of oligodendrocyte differentiation   • cell periphery   • cellular anatomical structure   • cell surface   • membrane   • plasma membrane   • external side of plasma membrane   • side of membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space
Gene OntologyCellular Component• cell periphery   • cellular anatomical structure   • cell surface   • membrane   • plasma membrane   • external side of plasma membrane   • side of membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • cell leading edge   • intracellular anatomical structure   • cytoplasm   • anchoring junction   • cell junction   • intracellular organelle   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • lysosome   • protein-containing complex   • cytoplasmic vesicle   • intracellular vesicle   • early endosome   • endosome   • endomembrane system   • late endosome
SCOP2Domain Identifier• G protein-coupled receptor-like
SCOP2Family Identifier• G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP61073
Sequence
>8YU7_poly_Chain_R
EPCFREENA NFNKIFLPT IYSIIFLTG IVGNGLVIL VMGYQKKLR 
SMTDKYRLH LSVADLLFV ITLPFWAVD AVANWYFGN FLCKAVHVI 
YTVNLYSSV LILAFISLD RYLAIVHAT NSQRPRKLL AEKVVYVGV 
WIPALLLTI PDFIFANVS EADDRYICD RFYPNDLWV VVFQFQHIM 
VGLILPGIV ILSCYCIII SKLSHSKGH QKRKALKTT VILILAFFA 
CWLPYYIGI SIDSFILLE IIKQGCEFE NTVHKWISI TEALAFFHC 
CLNPILYAF L


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YU7AProteinChemokineCXCR4Homo sapiens---3.012025-03-05doi.org/10.1016/j.celrep.2025.115255
8U4NAProteinChemokineCXCR4Homo sapiens--Gi1/β1/γ22.722024-03-13doi.org/10.1101/2024.02.09.579708
8U4N (No Gprot) AProteinChemokineCXCR4Homo sapiens--2.722024-03-13doi.org/10.1101/2024.02.09.579708
8U4OAProteinChemokineCXCR4Homo sapiensCXCL12-Gi1/β1/γ23.292024-03-13doi.org/10.1101/2024.02.09.579708
8U4O (No Gprot) AProteinChemokineCXCR4Homo sapiensCXCL12-3.292024-03-13doi.org/10.1101/2024.02.09.579708
8U4PAProteinChemokineCXCR4Homo sapiensAMD3100-Gi1/β1/γ23.152024-03-13doi.org/10.1101/2024.02.09.579708
8U4P (No Gprot) AProteinChemokineCXCR4Homo sapiensAMD3100-3.152024-03-13doi.org/10.1101/2024.02.09.579708
8U4QAProteinChemokineCXCR4Homo sapiensREGN7663-Fab-Gi1/β1/γ23.362024-03-13doi.org/10.1101/2024.02.09.579708
8U4Q (No Gprot) AProteinChemokineCXCR4Homo sapiensREGN7663-Fab-3.362024-03-13doi.org/10.1101/2024.02.09.579708
8U4RAProteinChemokineCXCR4Homo sapiensREGN7663-Fab--3.12024-03-13doi.org/10.1101/2024.02.09.579708
3ODUAProteinChemokineCXCR4Homo sapiensIT1t--2.52010-10-27doi.org/10.1126/science.1194396
3OE0AProteinChemokineCXCR4Homo sapiensCVX15--2.92010-10-27doi.org/10.1126/science.1194396
3OE6AProteinChemokineCXCR4Homo sapiensIT1t--3.22010-10-27doi.org/10.1126/science.1194396
3OE8AProteinChemokineCXCR4Homo sapiensIT1t--3.12010-10-27doi.org/10.1126/science.1194396
3OE9AProteinChemokineCXCR4Homo sapiensIT1t--3.12010-10-27doi.org/10.1126/science.1194396
4RWSAProteinChemokineCXCR4Homo sapiensvMIP-II--3.12015-02-11doi.org/10.1126/science.1261064
8K3ZAProteinChemokineCXCR4Homo sapiensCXCL12-Gi1/β1/γ12.812024-07-17doi.org/10.1016/j.celrep.2024.114578
8K3Z (No Gprot) AProteinChemokineCXCR4Homo sapiensCXCL12-2.812024-07-17doi.org/10.1016/j.celrep.2024.114578
8U4SAProteinChemokineCXCR4Homo sapiensREGN7663-Fab--3.352024-03-13doi.org/10.1038/s41594-024-01397-1
8U4TAProteinChemokineCXCR4Homo sapiensREGN7663-Fab--3.382024-03-13doi.org/10.1038/s41594-024-01397-1
8ZPLAProteinChemokineCXCR4Homo sapiensHF51116--3.012025-02-26doi.org/10.1073/pnas.2425795122
8ZPMAProteinChemokineCXCR4Homo sapiensAMD070--3.22025-02-26doi.org/10.1073/pnas.2425795122
8ZPNAProteinChemokineCXCR4Homo sapiensAMD3100--3.312025-02-26doi.org/10.1073/pnas.2425795122




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Download 8YU7_poly.zip



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