psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C13	R:R:C258	7.28	No	No	0	7	5
2	R:R:D165	R:R:T14	2.89	No	No	0	2	3
3	R:R:I15	R:R:Y176	10.88	Yes	No	7	2	6
4	R:R:I15	R:R:K262	7.27	Yes	No	0	2	3
5	R:R:F265	R:R:I15	6.28	Yes	Yes	7	3	2
6	R:R:D16	R:R:T18	8.67	No	No	0	3	3
7	R:R:H17	R:R:H20	4.78	Yes	No	0	4	4
8	R:R:H17	R:R:Q21	9.89	Yes	No	2	4	4
9	R:R:H17	R:R:H84	4.78	Yes	Yes	2	4	3
10	R:R:D85	R:R:H17	12.61	Yes	Yes	2	4	4
11	R:R:I19	R:R:T18	4.56	No	No	0	3	3
12	R:R:I19	R:R:N266	12.74	No	No	0	3	1
13	R:R:F265	R:R:H20	3.39	Yes	No	0	3	4
14	R:R:H84	R:R:Q21	9.89	Yes	No	2	3	4
15	R:R:D85	R:R:Q21	2.61	Yes	No	2	4	4
16	R:R:A24	R:R:Y28	2.67	No	Yes	8	5	8
17	R:R:A24	R:R:V81	3.39	No	No	8	5	5
18	R:R:P25	R:R:V81	3.53	No	No	0	6	5
19	R:R:L273	R:R:V27	10.43	No	No	0	5	5
20	R:R:F277	R:R:V27	2.62	No	No	0	4	5
21	R:R:V81	R:R:Y28	2.52	No	Yes	8	5	8
22	R:R:L74	R:R:V31	2.98	Yes	No	0	7	7
23	R:R:F277	R:R:V31	2.62	No	No	0	4	7
24	R:R:V280	R:R:V34	3.21	No	No	0	7	6
25	R:R:F36	R:R:P37	5.78	No	No	0	6	5
26	R:R:N39	R:R:T64	2.92	Yes	No	0	9	8
27	R:R:D67	R:R:N39	6.73	Yes	Yes	0	9	9
28	R:R:L68	R:R:N39	4.12	No	Yes	0	7	9
29	R:R:I71	R:R:N39	2.83	No	Yes	0	5	9
30	R:R:N39	R:R:P283	6.52	Yes	No	0	9	9
31	R:R:S42	R:R:T64	7.99	No	No	0	8	8
32	R:R:P283	R:R:S42	3.56	No	No	0	9	8
33	R:R:C287	R:R:S42	6.89	No	No	0	6	8
34	R:R:L43	R:R:T64	5.9	No	No	0	6	8
35	R:R:L48	R:R:Y44	4.69	No	No	0	4	4
36	R:R:F288	R:R:F45	4.29	No	No	0	7	6
37	R:R:F45	R:R:T293	5.19	No	No	0	6	8
38	R:R:D296	R:R:L48	6.79	No	No	0	4	4
39	R:R:N54	R:R:Q49	3.96	No	Yes	0	7	4
40	R:R:Q49	R:R:T292	2.83	Yes	No	0	4	6
41	R:R:E55	R:R:Y59	5.61	Yes	Yes	5	6	7
42	R:R:D118	R:R:E55	14.29	No	Yes	5	8	6
43	R:R:E55	R:R:R133	8.14	Yes	Yes	5	6	7
44	R:R:A138	R:R:E55	3.02	No	Yes	5	7	6
45	R:R:I115	R:R:L56	2.85	No	No	0	8	7
46	R:R:D118	R:R:L56	5.43	No	No	0	8	7
47	R:R:A138	R:R:V58	5.09	No	No	0	7	6
48	R:R:C114	R:R:Y59	6.72	No	Yes	0	6	7
49	R:R:A138	R:R:Y59	5.34	No	Yes	5	7	7
50	R:R:V141	R:R:Y59	3.79	No	Yes	0	4	7
51	R:R:C287	R:R:L60	3.17	No	No	0	6	7
52	R:R:F111	R:R:N62	12.08	Yes	No	1	7	9
53	R:R:N62	R:R:S142	8.94	No	No	1	9	6
54	R:R:N62	R:R:W146	6.78	No	Yes	1	9	9
55	R:R:D67	R:R:L63	2.71	Yes	Yes	1	9	9
56	R:R:L63	R:R:S108	3	Yes	No	0	9	9
57	R:R:D282	R:R:L63	6.79	Yes	Yes	1	9	9
58	R:R:F69	R:R:V65	2.62	No	No	0	7	5
59	R:R:A66	R:R:I107	3.25	No	Yes	1	8	7
60	R:R:A66	R:R:W146	2.59	No	Yes	1	8	9
61	R:R:C279	R:R:D67	6.22	No	Yes	0	8	9
62	R:R:D282	R:R:D67	6.65	Yes	Yes	1	9	9
63	R:R:L101	R:R:Y70	4.69	No	Yes	0	6	6
64	R:R:N104	R:R:Y70	13.96	No	Yes	0	8	6
65	R:R:S276	R:R:Y70	7.63	No	Yes	0	7	6
66	R:R:C279	R:R:Y70	5.38	No	Yes	0	8	6
67	R:R:C279	R:R:I71	4.91	No	No	0	8	5
68	R:R:L100	R:R:S73	3	No	No	0	5	6
69	R:R:C97	R:R:F76	5.59	No	No	0	5	6
70	R:R:W77	R:R:Y80	4.82	Yes	No	0	6	5
71	R:R:C97	R:R:W77	2.61	No	Yes	0	5	6
72	R:R:L101	R:R:W77	18.22	No	Yes	0	6	6
73	R:R:C172	R:R:W77	6.53	No	Yes	0	9	6
74	R:R:L78	R:R:L82	5.54	No	No	0	7	4
75	R:R:Q79	R:R:Q83	10.24	No	No	6	4	4
76	R:R:Q79	R:R:S88	2.89	No	No	6	4	3
77	R:R:H89	R:R:Q79	13.6	No	No	0	7	4
78	R:R:W87	R:R:Y80	7.72	Yes	No	0	9	5
79	R:R:V171	R:R:Y80	2.52	No	No	0	3	5
80	R:R:N86	R:R:Q83	7.92	No	No	6	4	4
81	R:R:Q83	R:R:S88	7.22	No	No	6	4	3
82	R:R:D85	R:R:H84	23.95	Yes	Yes	2	4	3
83	R:R:H169	R:R:H84	11.94	Yes	Yes	2	2	3
84	R:R:D85	R:R:H169	18.91	Yes	Yes	2	4	2
85	R:R:N86	R:R:S88	5.96	No	No	6	4	3
86	R:R:S93	R:R:W87	3.71	No	Yes	0	5	9
87	R:R:C94	R:R:W87	5.22	No	Yes	0	9	9
88	R:R:C172	R:R:W87	7.84	No	Yes	0	9	9
89	R:R:D91	R:R:L92	8.14	No	No	0	3	2
90	R:R:L92	R:R:S93	3	No	No	0	2	5
91	R:R:L157	R:R:Q95	3.99	No	No	0	4	7
92	R:R:F173	R:R:G98	6.02	Yes	No	0	3	5
93	R:R:I99	R:R:S153	3.1	No	No	0	5	6
94	R:R:F156	R:R:I99	2.51	Yes	No	0	4	5
95	R:R:L101	R:R:Y102	7.03	No	Yes	0	6	5
96	R:R:F173	R:R:Y102	13.41	Yes	Yes	0	3	5
97	R:R:E174	R:R:Y102	6.73	No	Yes	0	5	5
98	R:R:Y102	R:R:Y268	3.97	Yes	Yes	0	5	5
99	R:R:L272	R:R:Y102	4.69	No	Yes	0	6	5
100	R:R:E103	R:R:F156	16.32	No	Yes	0	5	4
101	R:R:E103	R:R:R189	13.96	No	No	0	5	5
102	R:R:I105	R:R:N104	4.25	No	No	0	7	8
103	R:R:I105	R:R:Y106	9.67	No	Yes	0	7	7
104	R:R:F241	R:R:I105	6.28	Yes	No	0	9	7
105	R:R:V109	R:R:Y106	2.52	No	Yes	0	7	7
106	R:R:R189	R:R:Y106	8.23	No	Yes	0	5	7
107	R:R:H245	R:R:Y106	6.53	Yes	Yes	0	8	7
108	R:R:F111	R:R:I107	2.51	Yes	Yes	1	7	7
109	R:R:I107	R:R:I145	2.94	Yes	No	1	7	6
110	R:R:I107	R:R:W146	3.52	Yes	Yes	1	7	9
111	R:R:E149	R:R:I107	10.93	No	Yes	1	7	7
112	R:R:N278	R:R:S108	2.98	No	No	0	9	9
113	R:R:F237	R:R:V109	3.93	Yes	No	4	9	7
114	R:R:F241	R:R:V109	3.93	Yes	No	4	9	7
115	R:R:F111	R:R:S142	5.28	Yes	No	1	7	6
116	R:R:F111	R:R:I145	7.54	Yes	No	1	7	6
117	R:R:F111	R:R:W146	4.01	Yes	Yes	1	7	9
118	R:R:D282	R:R:L112	5.43	Yes	No	0	9	8
119	R:R:L112	R:R:Y286	8.21	No	Yes	0	8	9
120	R:R:C113	R:R:P197	3.77	No	No	0	7	9
121	R:R:C113	R:R:L200	3.17	No	No	0	7	6
122	R:R:I115	R:R:R119	6.26	No	No	3	8	9
123	R:R:I115	R:R:Y286	4.84	No	Yes	3	8	9
124	R:R:L200	R:R:S116	3	No	Yes	0	6	9
125	R:R:L201	R:R:S116	4.5	No	Yes	0	8	9
126	R:R:S116	R:R:S204	4.89	Yes	No	3	9	6
127	R:R:S116	R:R:Y205	3.82	Yes	Yes	3	9	8
128	R:R:L200	R:R:V117	4.47	No	No	0	6	5
129	R:R:D118	R:R:R133	4.76	No	Yes	5	8	7
130	R:R:R119	R:R:Y205	5.14	No	Yes	3	9	8
131	R:R:R119	R:R:Y286	4.12	No	Yes	3	9	9
132	R:R:A124	R:R:Y120	4	No	Yes	9	7	8
133	R:R:H125	R:R:Y120	6.53	Yes	Yes	9	6	8
134	R:R:G207	R:R:Y120	2.9	No	Yes	0	3	8
135	R:R:I208	R:R:Y120	3.63	No	Yes	0	8	8
136	R:R:F129	R:R:L121	3.65	No	No	0	6	5
137	R:R:I208	R:R:V123	6.14	No	No	0	8	8
138	R:R:A124	R:R:H125	2.93	No	Yes	9	7	6
139	R:R:F129	R:R:H125	3.39	No	Yes	0	6	6
140	R:R:F129	R:R:R128	3.21	No	No	0	6	4
141	R:R:F132	R:R:Q131	8.2	No	No	0	3	4
142	R:R:K136	R:R:T134	4.5	No	No	0	4	6
143	R:R:E149	R:R:W146	3.27	No	Yes	1	7	9
144	R:R:K148	R:R:T152	7.51	No	No	0	4	4
145	R:R:E149	R:R:T152	4.23	No	No	0	7	4
146	R:R:F156	R:R:Y155	3.09	Yes	No	0	4	8
147	R:R:W181	R:R:Y155	2.89	No	No	0	3	8
148	R:R:I185	R:R:Y155	6.04	No	No	0	5	8
149	R:R:F156	R:R:F173	3.22	Yes	Yes	0	4	3
150	R:R:H159	R:R:W181	27.51	No	No	0	4	3
151	R:R:E161	R:R:F173	13.99	No	Yes	0	4	3
152	R:R:R170	R:R:V162	5.23	No	No	0	4	5
153	R:R:I163	R:R:V171	4.61	No	No	0	1	3
154	R:R:E164	R:R:Q168	11.47	No	No	0	1	4
155	R:R:D165	R:R:N167	6.73	No	No	2	2	4
156	R:R:D165	R:R:H169	7.56	No	Yes	2	2	2
157	R:R:H169	R:R:N167	2.55	Yes	No	2	2	4
158	R:R:C172	R:R:F173	2.79	No	Yes	0	9	3
159	R:R:E174	R:R:H269	11.08	No	No	0	5	4
160	R:R:H175	R:R:Q179	3.71	No	No	0	4	1
161	R:R:F265	R:R:Y176	7.22	Yes	No	7	3	6
162	R:R:I178	R:R:Q182	8.23	No	No	0	4	4
163	R:R:I178	R:R:R251	8.77	No	No	0	4	5
164	R:R:Q179	R:R:W181	4.38	No	No	0	1	3
165	R:R:N186	R:R:Q182	5.28	No	No	0	4	4
166	R:R:I185	R:R:R189	3.76	No	No	0	5	5
167	R:R:L248	R:R:N186	12.36	No	No	0	5	4
168	R:R:N186	R:R:S252	4.47	No	No	0	4	6
169	R:R:S252	R:R:Y187	5.09	No	Yes	0	6	4
170	R:R:V253	R:R:Y187	6.31	No	Yes	0	4	4
171	R:R:F190	R:R:H245	5.66	No	Yes	0	6	8
172	R:R:F190	R:R:L249	21.92	No	No	0	6	5
173	R:R:G193	R:R:P197	4.06	No	No	0	5	9
174	R:R:F194	R:R:F237	4.29	Yes	Yes	4	8	9
175	R:R:F194	R:R:L238	3.65	Yes	No	4	8	5
176	R:R:F194	R:R:L242	7.31	Yes	Yes	4	8	4
177	R:R:F194	R:R:H245	14.71	Yes	Yes	0	8	8
178	R:R:F196	R:R:P197	2.89	No	No	0	5	9
179	R:R:F237	R:R:L201	3.65	Yes	No	0	9	8
180	R:R:S204	R:R:Y205	5.09	No	Yes	3	6	8
181	R:R:V230	R:R:Y205	8.83	No	Yes	0	7	8
182	R:R:V234	R:R:Y205	2.52	No	Yes	0	7	8
183	R:R:Q206	R:R:R210	3.5	No	No	0	4	3
184	R:R:L209	R:R:Q227	2.66	Yes	No	0	5	6
185	R:R:H216	R:R:R214	4.51	No	No	0	3	4
186	R:R:K223	R:R:T218	6.01	No	No	0	7	3
187	R:R:L231	R:R:Q227	2.66	No	No	0	4	6
188	R:R:R228	R:R:S232	6.59	No	No	0	6	6
189	R:R:L229	R:R:S232	3	No	No	0	7	6
190	R:R:L285	R:R:T233	7.37	Yes	No	0	8	7
191	R:R:T233	R:R:Y286	2.5	No	Yes	0	7	9
192	R:R:A281	R:R:I236	3.25	No	No	0	6	6
193	R:R:F237	R:R:F241	7.5	Yes	Yes	4	9	9
194	R:R:L238	R:R:L242	2.77	No	Yes	4	5	4
195	R:R:F241	R:R:H245	3.39	Yes	Yes	0	9	8
196	R:R:F241	R:R:T275	5.19	Yes	No	0	9	7
197	R:R:F241	R:R:N278	3.62	Yes	No	0	9	9
198	R:R:L242	R:R:P243	3.28	Yes	No	0	4	9
199	R:R:L242	R:R:V246	2.98	Yes	No	0	4	5
200	R:R:L248	R:R:Y244	4.69	No	Yes	0	5	7
201	R:R:Y244	R:R:Y268	10.92	Yes	Yes	0	7	5
202	R:R:S271	R:R:Y244	7.63	No	Yes	0	7	7
203	R:R:L272	R:R:Y244	4.69	No	Yes	0	6	7
204	R:R:L247	R:R:V246	2.98	No	No	0	4	5
205	R:R:A267	R:R:L247	3.15	No	No	0	5	4
206	R:R:L247	R:R:S271	4.5	No	No	0	4	7
207	R:R:L249	R:R:S252	3	No	No	0	5	6
208	R:R:E255	R:R:V250	4.28	No	No	0	3	5
209	R:R:R251	R:R:Y268	18.52	No	Yes	0	5	5
210	R:R:E255	R:R:F260	4.66	No	No	0	3	1
211	R:R:E255	R:R:V264	4.28	No	No	0	3	5
212	R:R:F260	R:R:S257	11.89	No	No	0	1	5
213	R:R:D259	R:R:F260	4.78	No	No	0	1	1
214	R:R:A267	R:R:V264	3.39	No	No	0	5	5
215	R:R:F265	R:R:H269	23.76	Yes	No	0	3	4
216	R:R:H269	R:R:Y268	4.36	No	Yes	0	4	5
217	R:R:D282	R:R:N278	14.81	Yes	No	0	9	9
218	R:R:S290	R:R:T293	6.4	No	No	0	8	8
219	R:R:E291	R:R:T292	2.82	No	No	0	6	6
220	R:R:H294	R:R:T293	4.11	No	No	0	8	8
221	R:R:S73	R:R:W77	2.47	No	Yes	0	6	6
222	R:R:F111	R:R:L63	2.44	Yes	Yes	1	7	9
223	R:R:F190	R:R:L191	2.44	No	No	0	6	4
224	R:R:F277	R:R:L274	2.44	No	No	0	4	7
225	R:R:I208	R:R:Y205	2.42	No	Yes	0	8	8
226	R:R:L74	R:R:Y28	2.34	Yes	Yes	0	7	8
227	R:R:L78	R:R:Y28	2.34	No	Yes	0	7	8
228	R:R:L74	R:R:Y70	2.34	Yes	Yes	0	7	6
229	R:R:F76	R:R:H89	2.26	No	No	0	6	7
230	R:R:H130	R:R:R133	2.26	No	Yes	0	5	7
231	R:R:F45	R:R:Y44	2.06	No	No	0	6	4
232	R:R:Y44	R:R:Y47	1.99	No	No	0	4	2
233	R:R:C61	R:R:G46	1.96	No	No	0	6	6
234	R:R:C113	R:R:G110	1.96	No	No	0	7	5
235	R:R:A38	R:R:G35	1.95	No	No	0	7	8
236	R:R:A38	R:R:P283	1.87	No	No	0	7	9
237	R:R:G35	R:R:V34	1.84	No	No	0	8	6
238	R:R:G193	R:R:V192	1.84	No	No	0	5	4
239	R:R:A124	R:R:A211	1.79	No	No	0	7	5
240	R:R:G57	R:R:I50	1.76	No	No	0	7	5
241	R:R:C13	R:R:S12	1.72	No	No	0	7	6
242	R:R:G90	R:R:L92	1.71	No	No	0	8	2
243	R:R:C94	R:R:V162	1.71	No	No	0	9	5
244	R:R:A137	R:R:T134	1.68	No	No	0	1	6
245	R:R:C13	R:R:I15	1.64	No	Yes	0	7	2
246	R:R:L32	R:R:P75	1.64	No	No	0	6	9
247	R:R:G46	R:R:Q49	1.64	No	Yes	0	6	4
248	R:R:G57	R:R:Q49	1.64	No	Yes	0	7	4
249	R:R:L74	R:R:P75	1.64	Yes	No	0	7	9
250	R:R:G207	R:R:Q206	1.64	No	No	0	3	4
251	R:R:C240	R:R:I236	1.64	No	No	0	8	6
252	R:R:V29	R:R:V33	1.6	No	No	0	6	5
253	R:R:V139	R:R:V143	1.6	No	No	0	3	4
254	R:R:S215	R:R:T218	1.6	No	No	0	5	3
255	R:R:S290	R:R:T292	1.6	No	No	0	8	6
256	R:R:T30	R:R:V26	1.59	No	No	0	4	5
257	R:R:T30	R:R:V29	1.59	No	No	0	4	6
258	R:R:T30	R:R:V34	1.59	No	No	0	4	6
259	R:R:C199	R:R:L195	1.59	No	No	0	3	4
260	R:R:G217	R:R:H216	1.59	No	No	0	4	3
261	R:R:I50	R:R:V58	1.54	No	No	0	5	6
262	R:R:I226	R:R:V230	1.54	No	No	0	7	7
263	R:R:H125	R:R:P126	1.53	Yes	No	0	6	8
264	R:R:L285	R:R:S232	1.5	Yes	No	0	8	6
265	R:R:L23	R:R:V27	1.49	No	No	0	5	5
266	R:R:L43	R:R:V65	1.49	No	No	0	6	5
267	R:R:L100	R:R:V96	1.49	No	No	0	5	4
268	R:R:L202	R:R:V234	1.49	No	No	0	3	7
269	R:R:L209	R:R:V212	1.49	Yes	No	0	5	8
270	R:R:L209	R:R:V230	1.49	Yes	No	0	5	7
271	R:R:L229	R:R:V289	1.49	No	No	0	7	6
272	R:R:L285	R:R:V289	1.49	Yes	No	0	8	6
273	R:R:Q95	R:R:V96	1.43	No	No	0	7	4
274	R:R:I99	R:R:L157	1.43	No	No	0	5	4
275	R:R:I154	R:R:L151	1.43	No	No	0	5	4
276	R:R:E160	R:R:V162	1.43	No	No	0	5	5
277	R:R:I198	R:R:L238	1.43	No	No	0	6	5
278	R:R:I236	R:R:L285	1.43	No	Yes	0	6	8
279	R:R:P177	R:R:Y176	1.39	No	No	0	4	6
280	R:R:A122	R:R:R133	1.38	No	Yes	0	8	7
281	R:R:A180	R:R:R183	1.38	No	No	0	1	2
282	R:R:L191	R:R:L195	1.38	No	No	0	4	4
283	R:R:H159	R:R:M158	1.31	No	No	0	4	4
284	R:R:E166	R:R:N167	1.31	No	No	0	3	4
285	R:R:R222	R:R:T218	1.29	No	No	0	5	3
286	R:R:F36	R:R:I71	1.26	No	No	0	6	5
287	R:R:V253	R:R:W254	1.23	No	No	0	4	2
288	R:R:F288	R:R:L41	1.22	No	No	0	7	6
289	R:R:L209	R:R:R213	1.21	Yes	No	0	5	4
290	R:R:F265	R:R:N266	1.21	Yes	No	0	3	1
291	R:R:Q219	R:R:R222	1.17	No	No	0	4	5
292	R:R:R183	R:R:Y187	1.03	No	Yes	0	2	4
293	R:R:Y187	R:R:Y188	0.99	Yes	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I15	6.5175	4	7	2
2	R:R:H17	8.015	4	2	4
3	R:R:Y28	2.4675	4	8	8
4	R:R:N39	4.624	5	0	9
5	R:R:Q49	2.5175	4	0	4
6	R:R:E55	7.765	4	5	6
7	R:R:Y59	5.365	4	5	7
8	R:R:L63	3.735	4	1	9
9	R:R:D67	5.5775	4	1	9
10	R:R:Y70	6.8	5	0	6
11	R:R:L74	2.325	4	0	7
12	R:R:W77	6.93	5	0	6
13	R:R:H84	12.64	4	2	3
14	R:R:D85	14.52	4	2	4
15	R:R:W87	6.1225	4	0	9
16	R:R:Y102	7.166	5	0	5
17	R:R:Y106	6.7375	4	0	7
18	R:R:I107	4.63	5	1	7
19	R:R:F111	5.64333	6	1	7
20	R:R:S116	4.0525	4	3	9
21	R:R:Y120	4.265	4	9	8
22	R:R:H125	3.595	4	9	6
23	R:R:R133	4.135	4	5	7
24	R:R:W146	4.034	5	1	9
25	R:R:F156	6.285	4	0	4
26	R:R:H169	10.24	4	2	2
27	R:R:F173	7.886	5	0	3
28	R:R:Y187	3.355	4	0	4
29	R:R:F194	7.49	4	4	8
30	R:R:Y205	4.63667	6	3	8
31	R:R:L209	1.7125	4	0	5
32	R:R:F237	4.8425	4	4	9
33	R:R:F241	4.985	6	4	9
34	R:R:L242	4.085	4	4	4
35	R:R:Y244	6.9825	4	0	7
36	R:R:H245	7.5725	4	0	8
37	R:R:F265	8.372	5	7	3
38	R:R:Y268	9.4425	4	0	5
39	R:R:D282	8.42	4	1	9
40	R:R:L285	2.9475	4	0	8
41	R:R:Y286	4.9175	4	3	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F265	R:R:I15	12.7666	6.28	Yes	Yes	7	3	2
2	R:R:F265	R:R:H20	37.0715	3.39	Yes	No	0	3	4
3	R:R:H17	R:R:H20	34.8588	4.78	Yes	No	0	4	4
4	R:R:H17	R:R:H84	14.9306	4.78	Yes	Yes	2	4	3
5	R:R:H169	R:R:H84	12.6779	11.94	Yes	Yes	2	2	3
6	R:R:D165	R:R:H169	10.1503	7.56	No	Yes	2	2	2
7	R:R:D85	R:R:H17	14.9306	12.61	Yes	Yes	2	4	4
8	R:R:D85	R:R:H169	12.6779	18.91	Yes	Yes	2	4	2
9	R:R:F265	R:R:N266	10.2656	1.21	Yes	No	0	3	1
10	R:R:L74	R:R:Y28	10.239	2.34	Yes	Yes	0	7	8
11	R:R:L74	R:R:Y70	25.0055	2.34	Yes	Yes	0	7	6
12	R:R:L101	R:R:Y70	100	4.69	No	Yes	0	6	6
13	R:R:L101	R:R:Y102	76.2937	7.03	No	Yes	0	6	5
14	R:R:E174	R:R:Y102	30.8279	6.73	No	Yes	0	5	5
15	R:R:E174	R:R:H269	29.7592	11.08	No	No	0	5	4
16	R:R:F265	R:R:H269	65.8596	23.76	Yes	No	0	3	4
17	R:R:Y102	R:R:Y268	41.8651	3.97	Yes	Yes	0	5	5
18	R:R:H269	R:R:Y268	38.628	4.36	No	Yes	0	4	5
19	R:R:L74	R:R:V31	10.239	2.98	Yes	No	0	7	7
20	R:R:C279	R:R:Y70	80.4842	5.38	No	Yes	0	8	6
21	R:R:C279	R:R:D67	63.8863	6.22	No	Yes	0	8	9
22	R:R:D67	R:R:N39	32.0429	6.73	Yes	Yes	0	9	9
23	R:R:N39	R:R:P283	26.2826	6.52	Yes	No	0	9	9
24	R:R:A38	R:R:P283	17.8396	1.87	No	No	0	7	9
25	R:R:A38	R:R:G35	15.6401	1.95	No	No	0	7	8
26	R:R:G35	R:R:V34	13.4318	1.84	No	No	0	8	6
27	R:R:C279	R:R:I71	19.9104	4.91	No	No	0	8	5
28	R:R:I71	R:R:N39	17.0502	2.83	No	Yes	0	5	9
29	R:R:N39	R:R:T64	15.3962	2.92	Yes	No	0	9	8
30	R:R:D282	R:R:D67	54.2858	6.65	Yes	Yes	1	9	9
31	R:R:D282	R:R:L112	64.6002	5.43	Yes	No	0	9	8
32	R:R:L112	R:R:Y286	63.7001	8.21	No	Yes	0	8	9
33	R:R:I115	R:R:Y286	32.8899	4.84	No	Yes	3	8	9
34	R:R:I115	R:R:L56	40.2909	2.85	No	No	0	8	7
35	R:R:D118	R:R:L56	39.1646	5.43	No	No	0	8	7
36	R:R:D118	R:R:E55	33.626	14.29	No	Yes	5	8	6
37	R:R:A138	R:R:E55	28.4777	3.02	No	Yes	5	7	6
38	R:R:A138	R:R:V58	27.3824	5.09	No	No	0	7	6
39	R:R:I50	R:R:V58	26.0121	1.54	No	No	0	5	6
40	R:R:G57	R:R:I50	24.6331	1.76	No	No	0	7	5
41	R:R:G57	R:R:Q49	23.2451	1.64	No	Yes	0	7	4
42	R:R:Q49	R:R:T292	17.6001	2.83	Yes	No	0	4	6
43	R:R:S290	R:R:T292	14.8907	1.6	No	No	0	8	6
44	R:R:S290	R:R:T293	13.4318	6.4	No	No	0	8	8
45	R:R:F45	R:R:T293	10.4962	5.19	No	No	0	6	8
46	R:R:D67	R:R:L63	11.5472	2.71	Yes	Yes	1	9	9
47	R:R:F111	R:R:L63	26.0742	2.44	Yes	Yes	1	7	9
48	R:R:N104	R:R:Y70	29.7548	13.96	No	Yes	0	8	6
49	R:R:L101	R:R:W77	37.5637	18.22	No	Yes	0	6	6
50	R:R:C97	R:R:W77	13.0327	2.61	No	Yes	0	5	6
51	R:R:C97	R:R:F76	11.5738	5.59	No	No	0	5	6
52	R:R:W77	R:R:Y80	12.6824	4.82	Yes	No	0	6	5
53	R:R:F173	R:R:Y102	18.7664	13.41	Yes	Yes	0	3	5
54	R:R:C172	R:R:W87	15.1168	7.84	No	Yes	0	9	9
55	R:R:S93	R:R:W87	10.1858	3.71	No	Yes	0	5	9
56	R:R:C94	R:R:W87	10.4075	5.22	No	Yes	0	9	9
57	R:R:F156	R:R:F173	15.3652	3.22	Yes	Yes	0	4	3
58	R:R:L272	R:R:Y102	10.208	4.69	No	Yes	0	6	5
59	R:R:Y244	R:R:Y268	18.0746	10.92	Yes	Yes	0	7	5
60	R:R:E103	R:R:R189	10.6603	13.96	No	No	0	5	5
61	R:R:I105	R:R:N104	29.3912	4.25	No	No	0	7	8
62	R:R:R189	R:R:Y106	22.7218	8.23	No	Yes	0	5	7
63	R:R:F241	R:R:I105	29.2448	6.28	Yes	No	0	9	7
64	R:R:V109	R:R:Y106	11.8398	2.52	No	Yes	0	7	7
65	R:R:H245	R:R:Y106	10.2035	6.53	Yes	Yes	0	8	7
66	R:R:F241	R:R:H245	22.274	3.39	Yes	Yes	0	9	8
67	R:R:L249	R:R:S252	11.7378	3	No	No	0	5	6
68	R:R:F190	R:R:L249	12.5892	21.92	No	No	0	6	5
69	R:R:F190	R:R:H245	17.1655	5.66	No	Yes	0	6	8
70	R:R:S271	R:R:Y244	18.0302	7.63	No	Yes	0	7	7
71	R:R:L247	R:R:S271	17.1833	4.5	No	No	0	4	7
72	R:R:L247	R:R:V246	16.3319	2.98	No	No	0	4	5
73	R:R:L242	R:R:V246	17.0635	2.98	Yes	No	0	4	5
74	R:R:F194	R:R:L242	19.13	7.31	Yes	Yes	4	8	4
75	R:R:F194	R:R:H245	10.9751	14.71	Yes	Yes	0	8	8
76	R:R:F241	R:R:N278	35.2179	3.62	Yes	No	0	9	9
77	R:R:D282	R:R:N278	28.93	14.81	Yes	No	0	9	9
78	R:R:F237	R:R:F241	29.6883	7.5	Yes	Yes	4	9	9
79	R:R:F194	R:R:F237	18.5624	4.29	Yes	Yes	4	8	9
80	R:R:C113	R:R:L200	10.9574	3.17	No	No	0	7	6
81	R:R:L200	R:R:S116	14.5404	3	No	Yes	0	6	9
82	R:R:L201	R:R:S116	41.639	4.5	No	Yes	0	8	9
83	R:R:F237	R:R:L201	42.5081	3.65	Yes	No	0	9	8
84	R:R:R119	R:R:Y286	21.529	4.12	No	Yes	3	9	9
85	R:R:S116	R:R:Y205	33.1826	3.82	Yes	Yes	3	9	8
86	R:R:R119	R:R:Y205	29.6661	5.14	No	Yes	3	9	8
87	R:R:I208	R:R:Y120	22.3848	3.63	No	Yes	0	8	8
88	R:R:I208	R:R:Y205	26.2117	2.42	No	Yes	0	8	8
89	R:R:H125	R:R:Y120	10.2612	6.53	Yes	Yes	9	6	8
90	R:R:W181	R:R:Y155	11.6137	2.89	No	No	0	3	8
91	R:R:H169	R:R:N167	10.1503	2.55	Yes	No	2	2	4
92	R:R:S252	R:R:Y187	11.0638	5.09	No	Yes	0	6	4
93	R:R:V230	R:R:Y205	13.9063	8.83	No	Yes	0	7	8
94	R:R:L209	R:R:V230	10.2922	1.49	Yes	No	0	5	7
95	R:R:T233	R:R:Y286	15.5337	2.5	No	Yes	0	7	9
96	R:R:L285	R:R:T233	14.1457	7.37	Yes	No	0	8	7
97	R:R:A267	R:R:L247	15.547	3.15	No	No	0	5	4
98	R:R:A267	R:R:V264	13.352	3.39	No	No	0	5	5
99	R:R:E255	R:R:V264	11.1481	4.28	No	No	0	3	5
100	R:R:I185	R:R:R189	10.4918	3.76	No	No	0	5	5
101	R:R:D282	R:R:L63	11.2988	6.79	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8Z3O

PDB Summary
PDB	8Z3O
Class	A
SubFamily	Orphan
Type	Orphan
SubType	GPR68
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.3
Date	2025-04-23
D.O.I.	To be published

Net Summary
I_min	2.5
Number of Linked Nodes	259
Number of Links	293
Number of Hubs	41
Number of Links mediated by Hubs	148
Number of Communities	9
Number of Nodes involved in Communities	48
Number of Links involved in Communities	62

Path Summary
Number Of Nodes in MetaPath	102
Number Of Links MetaPath	101
Number of Shortest Paths	56128
Length Of Smallest Path	3
Average Path Length	13.3214
Length of Longest Path	33
Minimum Path Strength	1.01
Average Path Strength	6.00759
Maximum Path Strength	17.42
Minimum Path Correlation	0.7
Average Path Correlation	0.923641
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	50.185
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.2947
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • positive regulation of cell communication • regulation of localization • establishment of protein localization • regulation of cellular process • nitrogen compound transport • response to stimulus • positive regulation of establishment of protein localization • cell communication • localization • carbohydrate homeostasis • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • regulation of biological process • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • intracellular glucose homeostasis • protein secretion • establishment of localization • cellular response to oxygen-containing compound • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • chemical homeostasis • response to glucose • response to chemical • glucose homeostasis • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • signaling • homeostatic process • positive regulation of biological process • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • amide transport • signal release • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • biological regulation • regulation of establishment of protein localization • export from cell • cell-cell signaling • response to oxygen-containing compound • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • cellular response to chemical stimulus • cellular homeostasis • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • cellular process • insulin secretion • positive regulation of signaling • developmental process • myeloid leukocyte differentiation • cellular developmental process • hemopoiesis • cell development • mononuclear cell differentiation • myeloid cell differentiation • cell differentiation • anatomical structure development • monocyte differentiation • leukocyte differentiation • multicellular organismal process • regulation of leukocyte differentiation • regulation of cell differentiation • regulation of cell development • positive regulation of developmental process • multicellular organism development • skeletal system development • regulation of immune system process • positive regulation of immune system process • regulation of osteoclast development • system development • positive regulation of cell development • regulation of myeloid leukocyte differentiation • osteoclast development • positive regulation of myeloid leukocyte differentiation • positive regulation of multicellular organismal process • regulation of developmental process • positive regulation of osteoclast differentiation • regulation of osteoclast differentiation • positive regulation of cell differentiation • positive regulation of hemopoiesis • bone cell development • osteoclast differentiation • regulation of multicellular organismal process • bone development • positive regulation of osteoclast development • regulation of multicellular organismal development • regulation of myeloid cell differentiation • animal organ development • immune system process • myeloid cell development • positive regulation of myeloid cell differentiation • regulation of hemopoiesis • positive regulation of leukocyte differentiation • defense response • response to stress • inflammatory response • G protein-coupled receptor signaling pathway • signal transduction • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to abiotic stimulus • cellular response to environmental stimulus • negative regulation of biological process • negative regulation of cellular process • negative regulation of cell differentiation • negative regulation of hemopoiesis • negative regulation of monocyte differentiation • regulation of monocyte differentiation • negative regulation of leukocyte differentiation • negative regulation of developmental process • negative regulation of myeloid cell differentiation • negative regulation of myeloid leukocyte differentiation • negative regulation of cell development • negative regulation of immune system process • negative regulation of multicellular organismal process • cell periphery • cellular anatomical structure • plasma membrane • membrane
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q15743
Sequence	>8Z3O_Chain_R S C T I D H T I H Q T L A P V V Y V T V L V V G F P A N C L S L Y F G Y L Q I K A R N E L G V Y L C N L T V A D L F Y I C S L P F W L Q Y V L Q H D N W S H G D L S C Q V C G I L L Y E N I Y I S V G F L C C I S V D R Y L A V A H P F R F H Q F R T L K A A V G V S V V I W A K E L L T S I Y F L M H E E V I E D E N Q H R V C F E H Y P I Q A W Q R A I N Y Y R F L V G F L F P I C L L L A S Y Q G I L R A V R R S H G T Q K S R K D Q I Q R L V L S T V V I F L A C F L P Y H V L L L V R S V W E A S C D F A K G V F N A Y H F S L L L T S F N C V A D P V L Y C F V S E T T H R D L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9BHM	A	Orphan	Orphan	GPR68	Homo sapiens	-	-	Gs/β1	2.9	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BHM (No Gprot)	A	Orphan	Orphan	GPR68	Homo sapiens	-	-		2.9	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BI6	A	Orphan	Orphan	GPR68	Homo sapiens	-	-	chim(Gs-CtGq)/β1/γ2	2.9	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BI6 (No Gprot)	A	Orphan	Orphan	GPR68	Homo sapiens	-	-		2.9	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	8Z3O	A	Orphan	Orphan	GPR68	Homo sapiens	-	-	-	3.3	2025-04-23	To be published
	8Z5H	A	Orphan	Orphan	GPR68	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.3	2025-04-23	To be published
	8Z5H (No Gprot)	A	Orphan	Orphan	GPR68	Homo sapiens	-	-		3.3	2025-04-23	To be published
	8Z68	A	Orphan	Orphan	GPR68	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.64	2025-04-23	To be published
	8Z68 (No Gprot)	A	Orphan	Orphan	GPR68	Homo sapiens	-	-		2.64	2025-04-23	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8Z3O.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.