Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L12 4.85402
2A:A:K34 4.535404
3A:A:H41 7.5025406
4A:A:S51 4.11754169
5A:A:K53 4.8054169
6A:A:F219 6.44167608
7A:A:H220 8.4325427
8A:A:F222 9.278527
9A:A:R228 6.0075429
10A:A:R231 8.5409
11A:A:K233 6.59143729
12A:A:W234 7.93509
13A:A:F238 11.4425409
14A:A:D249 9.594178
15A:A:Y253 8.225208
16A:A:L270 6.1075406
17A:A:F273 5.93857769
18A:A:W277 7.615666
19A:A:W281 10.002525
20A:A:L282 6.32754199
21A:A:I288 6.0075449
22A:A:F290 7.39167649
23A:A:K293 7.3975409
24A:A:F312 4.7156218
25A:A:F315 10.2975406
26A:A:E330 6.344223
27A:A:V334 3.4425404
28A:A:K338 8.02465
29A:A:Y339 6.75667663
30A:A:F340 8.7054217
31A:A:R342 7.152564
32A:A:E344 6.4065215
33A:A:F345 9.885468
34A:A:S349 4.76467
35A:A:Y360 8.5175848
36A:A:F363 9.358565
37A:A:T364 7.5449
38A:A:N371 7.194549
39A:A:R373 6.8254115
40A:A:R374 7.405444
41A:A:F376 7.716676118
42A:A:D381 7.57548
43A:A:I383 4.195408
44A:A:R385 4.21445
45A:A:H387 6.1625418
46A:A:L388 4.26254238
47A:A:Y391 7.55143714
48A:A:L394 4.01254238
49B:B:R8 2.588503
50B:B:I37 4.742592
51B:B:V40 6.5493
52B:B:L51 8.605439
53B:B:H54 7.55143739
54B:B:K57 12.294529
55B:B:Y59 9.47628
56B:B:W63 9.964507
57B:B:Q75 9.9325429
58B:B:D76 9.0025439
59B:B:L79 6.24754267
60B:B:I80 8.935438
61B:B:W82 9.82667639
62B:B:N88 5.905407
63B:B:K89 6.905639
64B:B:H91 5.6525405
65B:B:I93 5.815407
66B:B:W99 9.85629
67B:B:M101 4.78429
68B:B:Y105 4.595406
69B:B:Y111 6.4245104
70B:B:I123 4.05754106
71B:B:Y124 6.135406
72B:B:E130 3.3585273
73B:B:H142 8.855429
74B:B:Y145 7.29286728
75B:B:F151 5.54333609
76B:B:T159 6.7625429
77B:B:D163 9.165429
78B:B:W169 9.71833628
79B:B:I171 3.5985106
80B:B:Q176 5.54424
81B:B:F180 8.53577
82B:B:H183 9.224579
83B:B:D186 10.8375429
84B:B:F199 9.505479
85B:B:K209 10.935476
86B:B:W211 11.146578
87B:B:F222 7.832558
88B:B:H225 9.97833659
89B:B:D228 9.84429
90B:B:I232 4.705458
91B:B:F235 7.1185146
92B:B:F241 8.37833656
93B:B:D246 4.22429
94B:B:D247 10.3075459
95B:B:R251 10.49558
96B:B:F253 8.314556
97B:B:D254 6.01409
98B:B:D258 9.9457
99B:B:Y264 6.06833605
100B:B:I273 5.3775406
101B:B:R283 8.582599
102B:B:Y289 5.66286727
103B:B:D290 6.854526
104B:B:N295 7.8775426
105B:B:L300 5.585496
106B:B:K301 7.3275405
107B:B:H311 10.125129
108B:B:R314 12.246528
109B:B:L318 5.5725406
110B:B:T329 5.95754128
111B:B:W332 11.1657729
112B:B:D333 9.5554129
113B:B:L336 5.3175437
114B:B:K337 6.7725406
115B:B:I338 6.1575435
116B:B:W339 8.208509
117G:G:R27 6.0225458
118G:G:Y40 10.2254146
119G:G:D48 6.5775409
120G:G:P49 4.38407
121G:G:L51 3.254506
122G:G:N59 10.285439
123G:G:F61 8.34625838
124R:R:H17 9.5675414
125R:R:H20 8.848514
126R:R:F45 5.2985136
127R:R:L48 5.944134
128R:R:N54 7.1825417
129R:R:E55 5.832516
130R:R:L56 5.052517
131R:R:V58 3.215406
132R:R:Y59 6.49833617
133R:R:D67 6.698519
134R:R:Y70 6.77406
135R:R:W77 7.702506
136R:R:N86 5.4175404
137R:R:W87 7.6365299
138R:R:C97 4.87405
139R:R:Y102 7.9025415
140R:R:E103 12.34485
141R:R:V109 5.0775417
142R:R:F111 9.514157
143R:R:L112 4.7375418
144R:R:I115 5.0425418
145R:R:D118 8.7225418
146R:R:R119 8.285419
147R:R:Y120 5.205408
148R:R:F129 7.76406
149R:R:R133 5.548517
150R:R:W146 5.65159
151R:R:F156 6.682584
152R:R:N167 6.2025414
153R:R:H169 9.91412
154R:R:R170 3.8575404
155R:R:E174 9.34415
156R:R:Y176 9.468516
157R:R:W181 10.56583
158R:R:F190 5.5725416
159R:R:P197 3.9225409
160R:R:L201 4.87418
161R:R:Y205 4.97718
162R:R:T233 4.085407
163R:R:F237 6.464519
164R:R:F241 6.42167619
165R:R:Y244 7.468517
166R:R:H245 9.14518
167R:R:R251 9.1925405
168R:R:F260 6.4625401
169R:R:F265 10.0275413
170R:R:Y268 7.27333615
171R:R:H269 11.16514
172R:R:L273 4.535405
173R:R:D282 7.93519
174R:R:Y286 5.19167619
175R:R:C287 4.66254136
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D76 B:B:H54 25.80363.78YesYes399
2B:B:H54 B:B:W82 21.55664.23YesYes399
3B:B:D76 B:B:L55 27.059910.86YesNo096
4A:A:Y37 B:B:L55 28.1474.69NoNo046
5A:A:R42 A:A:Y37 28.456620.58NoNo094
6A:A:F222 A:A:R42 28.61133.21YesNo079
7A:A:F222 A:A:H220 1004.53YesYes277
8A:A:H220 A:A:K211 99.45467.86YesNo074
9A:A:K211 A:A:R61 99.3577.43NoNo048
10A:A:R61 A:A:T210 99.259310.35NoNo087
11A:A:M221 A:A:T210 99.06374.52NoNo087
12A:A:F212 A:A:M221 98.69546.22NoNo1898
13A:A:F212 A:A:F219 98.671311.79NoYes098
14A:A:F219 A:A:H41 87.25616.79YesYes086
15A:A:H41 A:A:I383 87.14775.3YesYes068
16A:A:F219 A:A:L43 16.40714.87YesNo087
17A:A:I245 A:A:L43 16.24464.28NoNo077
18A:A:F222 B:B:W99 84.837722.05YesYes279
19A:A:F238 B:B:W99 37.217315.03YesYes099
20A:A:F290 A:A:I245 13.23415.02YesNo497
21A:A:F222 A:A:I207 30.75613.77YesNo279
22A:A:I207 B:B:L117 30.74314.28NoNo299
23A:A:W234 B:B:L117 61.55684.56YesNo099
24A:A:R231 A:A:W234 43.849912YesYes099
25A:A:I276 A:A:R231 21.64427.52NoYes089
26B:B:L117 B:B:W99 30.87873.42NoYes299
27A:A:F238 A:A:W234 31.00796.01YesYes099
28A:A:W234 B:B:Y145 65.8844.82YesYes098
29A:A:K233 B:B:Y145 45.67043.58YesYes298
30A:A:K233 B:B:D228 19.92829.68YesYes299
31A:A:D272 A:A:R231 21.609910.72NoYes099
32B:B:Q75 B:B:W99 17.3737.67YesYes299
33A:A:K233 B:B:D246 21.68025.53YesYes299
34A:A:D272 A:A:F246 21.441911.94NoNo099
35A:A:F246 A:A:I276 27.21923.77NoNo098
36A:A:F246 A:A:F273 48.26817.5NoYes099
37A:A:F273 A:A:F345 14.38269.65YesYes698
38A:A:F273 A:A:L289 11.18413.65YesNo699
39A:A:L289 A:A:L291 10.79376.92NoNo098
40A:A:F345 A:A:L270 13.193912.18YesYes086
41A:A:F312 A:A:I308 11.2133.77YesNo087
42A:A:F273 A:A:I348 13.98445.02YesNo094
43A:A:I348 A:A:L270 13.19534.28NoYes046
44A:A:E344 A:A:L270 15.99193.98YesYes056
45A:A:H387 A:A:I383 86.48656.63YesYes088
46A:A:H387 A:A:Y391 83.54386.53YesYes184
47A:A:Y391 R:R:L56 82.53194.69YesYes147
48R:R:I115 R:R:L56 81.9474.28YesYes187
49B:B:C271 B:B:D290 21.46136.22NoYes256
50B:B:C271 B:B:Y289 20.15654.03NoYes257
51B:B:W297 B:B:Y289 16.77325.79NoYes287
52B:B:W297 B:B:Y264 16.53684.82NoYes085
53B:B:L285 B:B:Y264 12.9095.86NoYes065
54B:B:F278 B:B:L285 12.38699.74NoNo076
55B:B:F235 B:B:F278 11.86446.43YesNo067
56B:B:D228 B:B:S227 19.63992.94YesNo096
57B:B:E226 B:B:S227 39.52532.87NoNo036
58B:B:D247 B:B:E226 39.19929.09YesNo093
59B:B:D247 B:B:H225 27.90958.82YesYes599
60B:B:H225 B:B:T243 16.6266.85YesNo098
61B:B:F222 B:B:F253 15.96179.65YesYes586
62B:B:D246 B:B:S227 20.23742.94YesNo096
63B:B:F253 B:B:R251 17.95674.28YesYes568
64B:B:D247 B:B:T249 10.632713.01YesNo096
65G:G:N59 G:G:V54 14.04468.87YesNo096
66G:G:P49 G:G:V54 13.55533.53YesNo076
67G:G:D48 G:G:P49 12.93953.22YesYes097
68G:G:F61 G:G:N59 14.13427.25YesYes389
69B:B:L51 B:B:W82 18.16915.94YesYes399
70B:B:I338 B:B:L51 17.69467.14YesYes359
71B:B:G162 B:B:Y145 25.6354.35NoYes298
72B:B:G162 B:B:S161 25.50463.71NoNo299
73B:B:H142 B:B:S161 24.78812.55YesNo299
74B:B:H142 B:B:T159 14.67216.85YesYes299
75B:B:C121 B:B:T159 14.35483.38NoYes089
76B:B:C121 B:B:C149 14.38973.64NoNo088
77B:B:C149 B:B:T102 14.20678.45NoNo088
78B:B:C148 B:B:T102 14.02363.38NoNo068
79B:B:F241 B:B:L255 10.64693.65YesNo566
80B:B:L210 B:B:L255 16.30254.15NoNo056
81B:B:L210 B:B:R219 11.64513.64NoNo055
82R:R:I115 R:R:Y286 77.45717.25YesYes189
83R:R:L112 R:R:Y286 13.98485.86YesYes189
84R:R:F237 R:R:L112 13.75074.87YesYes198
85R:R:F237 R:R:F241 12.27388.57YesYes199
86R:R:F241 R:R:H245 21.80084.53YesYes198
87R:R:H245 R:R:Y244 15.79516.53YesYes187
88R:R:Y244 R:R:Y268 13.40125.96YesYes175
89R:R:D282 R:R:Y286 37.62644.6YesYes199
90R:R:D282 R:R:N278 12.234212.12YesNo099
91R:R:F241 R:R:N278 12.08789.67YesNo099
92R:R:L63 R:R:Y286 25.5153.52NoYes199
93R:R:D67 R:R:L63 25.37765.43YesNo199
94R:R:C279 R:R:D67 40.69456.22NoYes089
95R:R:C279 R:R:Y70 38.95685.38NoYes086
96R:R:L74 R:R:Y70 10.71425.86NoYes076
97R:R:D282 R:R:D67 25.69926.65YesYes199
98R:R:L101 R:R:Y70 27.55268.21NoYes066
99R:R:L101 R:R:W77 26.151419.36NoYes066
100R:R:D67 R:R:N39 10.382510.77YesNo099
101R:R:G98 R:R:W77 14.36654.22NoYes056
102R:R:F173 R:R:G98 14.06459.03NoNo035
103R:R:F156 R:R:F173 12.86016.43YesNo043
104B:B:I338 G:G:F61 15.37827.54YesYes358
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8Z68
Class A
SubFamily Orphan
Type Orphan
SubType GPR68
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 2.64
Date 2025-04-23
D.O.I. To be published
Net Summary
Imin 3.38
Number of Linked Nodes 862
Number of Links 1062
Number of Hubs 175
Number of Links mediated by Hubs 647
Number of Communities 30
Number of Nodes involved in Communities 250
Number of Links involved in Communities 356
Path Summary
Number Of Nodes in MetaPath 105
Number Of Links MetaPath 104
Number of Shortest Paths 2911249
Length Of Smallest Path 3
Average Path Length 31.215
Length of Longest Path 59
Minimum Path Strength 1.33
Average Path Strength 7.20915
Maximum Path Strength 24.295
Minimum Path Correlation 0.7
Average Path Correlation 0.987686
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.5
Average % Of Corr. Nodes 38.9903
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 56.0587
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • positive regulation of cell communication   • regulation of localization   • establishment of protein localization   • regulation of cellular process   • nitrogen compound transport   • response to stimulus   • positive regulation of establishment of protein localization   • cell communication   • localization   • carbohydrate homeostasis   • establishment of localization in cell   • positive regulation of insulin secretion involved in cellular response to glucose stimulus   • positive regulation of insulin secretion   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • regulation of biological process   • regulation of hormone levels   • positive regulation of peptide hormone secretion   • establishment of protein localization to extracellular region   • intracellular glucose homeostasis   • protein secretion   • establishment of localization   • cellular response to oxygen-containing compound   • regulation of protein secretion   • regulation of secretion   • cellular response to carbohydrate stimulus   • chemical homeostasis   • response to glucose   • response to chemical   • glucose homeostasis   • positive regulation of protein localization   • insulin secretion involved in cellular response to glucose stimulus   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • signaling   • homeostatic process   • positive regulation of biological process   • positive regulation of secretion by cell   • hormone secretion   • protein localization to extracellular region   • positive regulation of protein transport   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • positive regulation of hormone secretion   • response to monosaccharide   • response to carbohydrate   • positive regulation of secretion   • amide transport   • signal release   • cellular response to hexose stimulus   • intracellular chemical homeostasis   • cellular response to monosaccharide stimulus   • positive regulation of cellular process   • positive regulation of peptide secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • biological regulation   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • response to oxygen-containing compound   • cellular response to glucose stimulus   • regulation of protein transport   • positive regulation of protein secretion   • peptide transport   • response to hexose   • cellular response to chemical stimulus   • cellular homeostasis   • positive regulation of transport   • regulation of cellular localization   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • regulation of insulin secretion involved in cellular response to glucose stimulus   • hormone transport   • regulation of cell communication   • cellular process   • insulin secretion   • positive regulation of signaling   • developmental process   • myeloid leukocyte differentiation   • cellular developmental process   • hemopoiesis   • cell development   • mononuclear cell differentiation   • myeloid cell differentiation   • cell differentiation   • anatomical structure development   • monocyte differentiation   • leukocyte differentiation   • multicellular organismal process   • regulation of leukocyte differentiation   • regulation of cell differentiation   • regulation of cell development   • positive regulation of developmental process   • multicellular organism development   • skeletal system development   • regulation of immune system process   • positive regulation of immune system process   • regulation of osteoclast development   • system development   • positive regulation of cell development   • regulation of myeloid leukocyte differentiation   • osteoclast development   • positive regulation of myeloid leukocyte differentiation   • positive regulation of multicellular organismal process   • regulation of developmental process   • positive regulation of osteoclast differentiation   • regulation of osteoclast differentiation   • positive regulation of cell differentiation   • positive regulation of hemopoiesis   • bone cell development   • osteoclast differentiation   • regulation of multicellular organismal process   • bone development   • positive regulation of osteoclast development   • regulation of multicellular organismal development   • regulation of myeloid cell differentiation   • animal organ development   • immune system process   • myeloid cell development   • positive regulation of myeloid cell differentiation   • regulation of hemopoiesis   • positive regulation of leukocyte differentiation   • defense response   • response to stress   • inflammatory response   • G protein-coupled receptor signaling pathway   • signal transduction   • response to pH   • cellular response to pH   • response to abiotic stimulus   • cellular response to abiotic stimulus   • cellular response to environmental stimulus   • negative regulation of biological process   • negative regulation of cellular process   • negative regulation of cell differentiation   • negative regulation of hemopoiesis   • negative regulation of monocyte differentiation   • regulation of monocyte differentiation   • negative regulation of leukocyte differentiation   • negative regulation of developmental process   • negative regulation of myeloid cell differentiation   • negative regulation of myeloid leukocyte differentiation   • negative regulation of cell development   • negative regulation of immune system process   • negative regulation of multicellular organismal process   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • sensory organ development   • eye development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8Z68_Chain_A
EKAEKIEKQ LQKDKQVYR ATHRLLLLG ASGKSTIVK QMRIHVTSG 
IFETKFQVD KVNFHMFDV GQRDERRKW IQCFNDVTA IIFVVSSYN 
RLQEALNFK SIWNNRWLR TISVILFLN KQDLLAEKV LAGKSKIED 
YFPEFARYT TPEDATPEP GEDPRVTRA KYFIRDEFL RISTASGDG 
RHYCYPHFT CVDTENRRF NDCRDIIQR MHLRQYELL TLSADAVRS 
MDNYKADDD SAI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8Z68_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8Z68_Chain_G
QARKLVEQL KMEANIDRI KVSKAAADL MAYCEAHAK EDPLLTPVP 
ASENPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ15743
Sequence
>8Z68_Chain_R
CTIDHTIHQ TLAPVVYVT VLVVGFPAN CLSLYFGYL QIKARNELG 
VYLCNLTVA DLFYICSLP FWLQYVLQH DNWSHGDLS CQVCGILLY 
ENIYISVGF LCCISVDRY LAVAHPFRF HQFRTLKAA VGVSVVIWA 
KELLTSIYF LMHEEVIED ENQHRVCFE HYPIQAWQR AINYYRFLV 
GFLFPICLL LASYQGILR AVRRSHGTQ KSRKDQIQR LVLSTVVIF 
LACFLPYHV LLLVRSVWE ASCDFAKGV FNAYHFSLL LTSFNCVAD 
PVLYCFVSE TTHRDL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9BHMAOrphanOrphanGPR68Homo sapiens--Gs/β12.92025-01-22doi.org/10.1016/j.cell.2024.11.036
9BHM (No Gprot) AOrphanOrphanGPR68Homo sapiens--2.92025-01-22doi.org/10.1016/j.cell.2024.11.036
9BI6AOrphanOrphanGPR68Homo sapiens--chim(Gs-CtGq)/β1/γ22.92025-01-22doi.org/10.1016/j.cell.2024.11.036
9BI6 (No Gprot) AOrphanOrphanGPR68Homo sapiens--2.92025-01-22doi.org/10.1016/j.cell.2024.11.036
8Z3OAOrphanOrphanGPR68Homo sapiens---3.32025-04-23To be published
8Z5HAOrphanOrphanGPR68Homo sapiens--chim(NtGi1-Gs)/β1/γ23.32025-04-23To be published
8Z5H (No Gprot) AOrphanOrphanGPR68Homo sapiens--3.32025-04-23To be published
8Z68AOrphanOrphanGPR68Homo sapiens--chim(NtGi1-Gs)/β1/γ22.642025-04-23To be published
8Z68 (No Gprot) AOrphanOrphanGPR68Homo sapiens--2.642025-04-23To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8Z68.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.