Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 4.6464
2A:A:H41 5.672596
3A:A:L43 3.818597
4A:A:L44 6.4125419
5A:A:L45 5.95438
6A:A:N50 6.3245199
7A:A:K53 4.69667639
8A:A:V217 3.64495
9A:A:F219 5.38833698
10A:A:H220 4.1375417
11A:A:F222 7.9925417
12A:A:V224 5.41419
13A:A:Q227 4.2619
14A:A:K233 5.726519
15A:A:W234 6.97419
16A:A:C237 3.2775418
17A:A:F238 5.938519
18A:A:I244 2.902518
19A:A:F246 4.17429
20A:A:V247 4.24537
21A:A:L270 5.01426
22A:A:F273 4.09857729
23A:A:W277 6.39857726
24A:A:W281 9.918336155
25A:A:L282 4.185409
26A:A:I288 4.11439
27A:A:L289 4.3875429
28A:A:F290 4.24714739
29A:A:L291 3.305428
30A:A:N292 3.945439
31A:A:K293 8.105409
32A:A:L297 3.125408
33A:A:V301 2.436507
34A:A:F312 3.288528
35A:A:Y318 6.285426
36A:A:F340 11.95427
37A:A:R342 6.164524
38A:A:F345 5.31429728
39A:A:S349 3.716527
40A:A:Y360 7.81638
41A:A:H362 6.82439
42A:A:F363 4.554525
43A:A:T364 5.282539
44A:A:D368 6.125439
45A:A:N371 5.546539
46A:A:R374 7.3775434
47A:A:F376 4.7425898
48A:A:D381 4.712538
49A:A:I383 3.624508
50A:A:Y391 5.156679114
51A:A:V394 3.23754228
52B:B:V40 4.673336123
53B:B:M45 3.90254124
54B:B:H54 6.18571769
55B:B:W63 5.556507
56B:B:Q75 9.74419
57B:B:D76 6.14333669
58B:B:K78 2.765468
59B:B:I80 8.6525468
60B:B:W82 9.762569
61B:B:D83 8.63254248
62B:B:K89 4.682569
63B:B:I93 4.335407
64B:B:L95 4.1065258
65B:B:W99 7.365619
66B:B:M101 3.828519
67B:B:Y105 3.402506
68B:B:Y111 4.43404
69B:B:L117 3.56519
70B:B:Y124 4.5456256
71B:B:N125 7.85254214
72B:B:L139 7.2825409
73B:B:H142 7.3645149
74B:B:Y145 5.82718
75B:B:F151 4.592509
76B:B:L152 4.255403
77B:B:D163 7.765149
78B:B:W169 8.586148
79B:B:F180 7.1185107
80B:B:H183 7.8985109
81B:B:D186 7.575419
82B:B:V187 4.3154109
83B:B:M188 5.2975418
84B:B:F199 5.23254109
85B:B:V200 6.5325486
86B:B:C204 6.7225417
87B:B:D205 3.574109
88B:B:K209 7.296106
89B:B:L210 4.4075405
90B:B:W211 7.786108
91B:B:F222 8.7125488
92B:B:H225 7.805689
93B:B:D228 9.245419
94B:B:I232 5.03488
95B:B:F234 6.055405
96B:B:F235 6.5125856
97B:B:P236 6.0025457
98B:B:N237 8.375455
99B:B:F241 6.08786
100B:B:T243 3.318588
101B:B:D247 7.4925489
102B:B:T249 4.6625486
103B:B:R251 8.6325488
104B:B:F253 6.688586
105B:B:D254 5.886509
106B:B:Y264 5.46167655
107B:B:H266 4.7175454
108B:B:F278 5.18557
109B:B:R283 9.84129
110B:B:L284 4.07254125
111B:B:L285 3.935456
112B:B:Y289 6.508557
113B:B:N295 7.602556
114B:B:W297 4.73558
115B:B:R304 6.42455
116B:B:H311 9.8675409
117B:B:R314 9.5325158
118B:B:L318 4.1125406
119B:B:T321 5.33754207
120B:B:D323 6.7254207
121B:B:W332 9.096159
122B:B:D333 4.265409
123B:B:L336 3.845467
124B:B:K337 6.7625236
125B:B:W339 9.084239
126G:G:Y40 9.4456
127G:G:D48 5.9025409
128R:R:V27 2.1725475
129R:R:Y28 4.11478
130R:R:N39 4.644509
131R:R:F45 7.515406
132R:R:N54 4.425117
133R:R:E55 4.8145116
134R:R:L56 3.9565117
135R:R:L63 3.27549
136R:R:D67 5.036549
137R:R:W77 5.23286776
138R:R:Y80 7.5475
139R:R:W87 5.08714779
140R:R:H89 4.18677
141R:R:C97 4.236575
142R:R:Y102 7.2025405
143R:R:Y106 6.1645177
144R:R:I107 4.194547
145R:R:F111 7.13333647
146R:R:L112 4.7125448
147R:R:D118 5.0985118
148R:R:R119 5.1225409
149R:R:Y120 4.2654188
150R:R:H125 5.83754186
151R:R:F127 5.708595
152R:R:F129 5.55254186
153R:R:R133 4.8545117
154R:R:W146 3.47667649
155R:R:C172 4.15479
156R:R:F173 5.612503
157R:R:E174 6.2685135
158R:R:Y176 6.37254136
159R:R:W181 6.784163
160R:R:Q182 5.6254164
161R:R:R189 6.51254175
162R:R:I198 2.4625406
163R:R:Y205 5.41429748
164R:R:S215 4.905435
165R:R:Q219 5.3575404
166R:R:F237 4.25549
167R:R:F241 5.218549
168R:R:Y244 5.46407
169R:R:R251 9.3775405
170R:R:E255 7.135403
171R:R:F265 6.9785133
172R:R:Y268 6.74135
173R:R:H269 7.05254134
174R:R:D282 6.7325449
175R:R:P283 4.1775409
176R:R:Y286 4.7775449
177R:R:F288 3.102507
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:H54 B:B:I80 13.030510.61YesYes698
2B:B:D76 B:B:H54 19.72362.52YesYes699
3B:B:D76 B:B:K78 12.61994.15YesYes698
4A:A:Y37 B:B:D76 33.91855.75YesYes649
5A:A:R42 A:A:Y37 38.66344.12NoYes094
6A:A:F219 A:A:H41 1007.92YesYes986
7A:A:F219 A:A:L43 1002.44YesYes987
8A:A:I245 A:A:L43 1005.71NoYes077
9A:A:F290 A:A:I245 1003.77YesNo097
10A:A:F290 A:A:V247 1002.62YesYes397
11A:A:N292 A:A:V247 1002.96YesYes397
12A:A:K293 A:A:N292 1005.6YesYes099
13A:A:D249 A:A:K293 10015.21NoYes089
14A:A:D249 A:A:S251 1002.94NoNo089
15A:A:L297 A:A:S251 1003YesNo089
16A:A:L297 A:A:S250 1003YesNo086
17A:A:Q294 A:A:S250 1002.89NoNo066
18A:A:F363 A:A:Q294 1007.03YesNo256
19A:A:F363 A:A:L291 1003.65YesYes258
20A:A:L291 A:A:V248 1002.98YesNo287
21A:A:F246 A:A:V248 1002.62YesNo297
22A:A:D272 A:A:F246 1005.97NoYes089
23A:A:D272 A:A:R231 10010.72NoNo089
24A:A:R231 A:A:W234 1009NoYes099
25A:A:V224 A:A:W234 59.45188.58YesYes199
26A:A:F238 A:A:V224 58.67342.62YesYes199
27A:A:F238 B:B:W99 56.70996.01YesYes199
28A:A:F222 B:B:W99 46.540516.04YesYes179
29A:A:F222 A:A:R42 40.24453.21YesNo079
30A:A:I375 A:A:L43 1002.85NoYes097
31A:A:F290 A:A:I375 1002.51YesNo099
32A:A:F290 A:A:T364 1006.49YesYes399
33A:A:N292 A:A:T364 1004.39YesYes399
34A:A:K293 A:A:L296 1009.87YesNo096
35A:A:L296 A:A:S251 1006.01NoNo069
36A:A:L289 A:A:L291 1004.15YesYes298
37A:A:F246 A:A:L289 1004.87YesYes299
38A:A:Q227 A:A:W234 83.8635.48YesYes199
39A:A:Q227 B:B:L117 57.26013.99YesYes199
40B:B:L117 B:B:W99 56.88255.69YesYes199
41A:A:I276 A:A:R231 99.21412.51NoNo089
42A:A:I276 A:A:L282 95.67162.85NoYes089
43A:A:L282 A:A:N279 92.53679.61YesNo098
44A:A:N279 A:A:W281 92.14346.78NoYes085
45A:A:W281 B:B:W332 29.14672.81YesYes1559
46B:B:S316 B:B:W332 20.15474.94NoYes099
47B:B:C317 B:B:S316 19.75893.44NoNo079
48B:B:C317 B:B:I58 10.313.27NoNo079
49A:A:H41 A:A:R38 1006.77YesNo064
50A:A:I383 A:A:R38 54.28032.51YesNo084
51A:A:H41 R:R:F127 54.34226.79YesYes965
52A:A:I383 R:R:F127 1005.02YesYes085
53A:A:F219 A:A:V217 54.39455.24YesYes985
54A:A:V217 R:R:F127 54.33243.93YesYes955
55A:A:F219 A:A:F376 54.79724.29YesYes988
56A:A:F376 R:R:F127 54.35215.36YesYes985
57A:A:R38 R:R:H130 55.35363.39NoNo045
58A:A:Q227 B:B:N119 25.7565.28YesNo099
59A:A:Y391 R:R:R119 1003.09YesYes049
60A:A:N387 A:A:Y391 1004.65NoYes1184
61A:A:I383 A:A:N387 1002.83YesNo088
62A:A:Y391 R:R:R133 54.02134.12YesYes1147
63R:R:H130 R:R:R133 55.29164.51NoYes057
64B:B:L284 B:B:V40 51.47012.98YesYes1253
65B:B:R283 B:B:V40 48.33117.85YesYes1293
66B:B:R314 B:B:T274 61.2556.47YesNo088
67B:B:S275 B:B:T274 60.86034.8NoNo088
68B:B:L318 B:B:S275 60.46564.5YesNo068
69B:B:L286 B:B:L318 56.1192.77NoYes076
70B:B:L286 B:B:V296 54.93475.96NoNo075
71B:B:L284 B:B:V296 54.14565.96YesNo055
72B:B:L51 B:B:W82 12.631918.22NoYes699
73B:B:L51 B:B:T87 13.02782.95NoNo095
74B:B:S97 B:B:W99 63.11972.47NoYes089
75B:B:D118 B:B:S97 62.330410.31NoNo098
76B:B:D118 B:B:I120 61.5415.6NoNo096
77B:B:E138 B:B:I120 59.96235.47NoNo066
78B:B:E138 B:B:S122 58.38362.87NoNo068
79B:B:S122 B:B:Y124 57.59453.82NoYes086
80B:B:V112 B:B:Y124 38.66013.79NoYes086
81B:B:V112 B:B:Y105 37.87063.79NoYes086
82B:B:H62 B:B:Y105 33.18252.18NoYes066
83B:B:H62 B:B:R150 32.392718.05NoNo066
84B:B:G144 B:B:N119 25.36013.39NoNo089
85B:B:D163 B:B:G144 24.96425.03YesNo098
86B:B:D163 B:B:H142 22.58747.56YesYes1499
87B:B:H142 B:B:T159 11.88876.85YesNo099
88B:B:A167 B:B:H142 10.30352.93NoYes1449
89B:B:C148 B:B:R150 12.64132.79NoNo066
90B:B:C148 B:B:L190 11.85136.35NoNo065
91B:B:L192 B:B:R150 18.96193.64NoNo056
92B:B:L152 B:B:L192 18.17194.15YesNo035
93B:B:L152 B:B:V158 15.01232.98YesNo035
94B:B:F199 B:B:V158 14.22243.93YesNo095
95B:B:L190 B:B:S160 11.06143NoNo056
96B:B:S160 B:B:V187 10.27156.46NoYes069
97B:B:L300 B:B:R283 47.14839.72NoYes069
98B:B:L300 G:G:C41 46.35734.76NoNo067
99B:B:F235 G:G:C41 45.96172.79YesNo067
100B:B:F235 B:B:N237 24.584610.87YesYes565
101B:B:G238 B:B:N237 22.20883.39NoYes075
102B:B:F234 B:B:G238 21.41633.01YesNo057
103B:B:F234 B:B:V200 17.0557.87YesYes056
104B:B:F235 B:B:F278 11.10578.57YesYes567
105R:R:I115 R:R:R119 1003.76NoYes089
106R:R:I115 R:R:Y286 1003.63NoYes089
107R:R:L112 R:R:Y286 1008.21YesYes489
108R:R:F237 R:R:L112 75.89692.44YesYes498
109R:R:F237 R:R:F241 1007.5YesYes499
110R:R:F241 R:R:T275 99.4422.59YesNo097
111R:R:T275 R:R:Y244 98.77073.75NoYes077
112R:R:L272 R:R:Y244 80.63164.69NoYes067
113R:R:L272 R:R:Y102 79.96024.69NoYes065
114R:R:E174 R:R:Y102 26.89658.98YesYes055
115R:R:R119 R:R:Y205 85.93985.14YesYes098
116R:R:S116 R:R:Y205 76.561910.17NoYes498
117R:R:L201 R:R:S116 76.23043NoNo089
118R:R:F237 R:R:L201 75.89674.87YesNo098
119R:R:L112 R:R:L63 78.59162.77YesYes489
120R:R:F111 R:R:L63 59.83292.44YesYes479
121R:R:F111 R:R:I107 29.24343.77YesYes477
122R:R:E149 R:R:I107 27.90259.56NoYes077
123R:R:E149 R:R:N104 55.13145.26NoNo078
124R:R:L100 R:R:N104 54.465.49NoNo058
125R:R:L100 R:R:S73 53.78864.5NoNo056
126R:R:S73 R:R:W77 26.2286.18NoYes766
127R:R:W77 R:R:W87 25.545.62YesYes769
128R:R:H89 R:R:W87 57.12773.17YesYes779
129R:R:G90 R:R:H89 48.39231.59NoYes087
130R:R:D91 R:R:G90 44.35961.68NoNo038
131R:R:D91 R:R:I163 40.3272.8NoNo031
132R:R:I163 R:R:R170 36.29446.26NoNo014
133R:R:N86 R:R:R170 20.16363.62NoNo044
134R:R:H169 R:R:N86 16.13096.38NoNo024
135R:R:H169 R:R:N167 12.09822.55NoNo024
136R:R:F111 R:R:W146 28.90653.01YesYes479
137R:R:E149 R:R:W146 27.90143.27NoYes079
138R:R:L101 R:R:Y102 31.59185.86NoYes065
139R:R:L101 R:R:W77 26.214110.25NoYes066
140R:R:C97 R:R:S73 26.88963.44YesNo756
141R:R:C97 R:R:W87 12.77475.22YesYes759
142R:R:F241 R:R:I105 44.3512.51YesNo097
143R:R:I105 R:R:Y106 43.68177.25NoYes077
144R:R:E103 R:R:Y106 23.523.37NoYes1757
145R:R:E103 R:R:F156 22.85317NoNo054
146R:R:F156 R:R:F173 20.83873.22NoYes043
147R:R:C172 R:R:F173 28.2292.79YesYes093
148R:R:C172 R:R:W87 25.53313.92YesYes799
149R:R:F173 R:R:Y102 20.83349.28YesYes035
150R:R:C97 R:R:F76 12.10195.59YesNo056
151R:R:F76 R:R:H89 11.42834.53NoYes067
152R:R:D85 R:R:Y80 12.100514.94NoYes045
153R:R:W77 R:R:Y28 16.14342.89YesYes768
154R:R:D67 R:R:L63 18.19232.71YesYes499
155R:R:D67 R:R:N39 34.35486.73YesYes099
156R:R:D282 R:R:L112 19.15035.43YesYes498
157R:R:D282 R:R:D67 18.1846.65YesYes499
158R:R:N39 R:R:P283 16.85176.52YesYes099
159R:R:C287 R:R:S42 12.13363.44NoNo068
160R:R:C287 R:R:F45 16.17824.19NoYes066
161R:R:F173 R:R:V162 10.76025.24YesNo035
162R:R:R189 R:R:Y106 13.44478.23YesYes1757
163R:R:N186 R:R:R189 12.77644.82NoYes1745
164R:R:N186 R:R:S252 24.20558.94NoNo046
165R:R:R183 R:R:S252 12.10263.95NoNo026
166R:R:I178 R:R:R183 10.75882.51NoNo042
167R:R:L248 R:R:Y244 13.44724.69NoYes057
168R:R:L248 R:R:N186 12.774213.73NoNo1754
169R:R:E174 R:R:Y268 10.0994.49YesYes1355
170R:R:S252 R:R:Y187 10.76386.36NoNo064
171R:R:D165 R:R:R170 12.09822.38NoNo024
172B:B:H54 B:B:S72 14.21525.58YesNo699
173A:A:W234 B:B:Y145 12.60344.82YesYes198
174A:A:W281 B:B:R314 61.43110YesYes1558
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9BI6
Class A
SubFamily Orphan
Type Orphan
SubType GPR68
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(Gs-CtGq)/Beta1/Gamma2
PDB Resolution 2.9
Date 2025-01-22
D.O.I. doi.org/10.1016/j.cell.2024.11.036
Net Summary
Imin 2.44
Number of Linked Nodes 761
Number of Links 986
Number of Hubs 177
Number of Links mediated by Hubs 647
Number of Communities 26
Number of Nodes involved in Communities 264
Number of Links involved in Communities 397
Path Summary
Number Of Nodes in MetaPath 175
Number Of Links MetaPath 174
Number of Shortest Paths 46670790
Length Of Smallest Path 3
Average Path Length 69.8032
Length of Longest Path 71
Minimum Path Strength 1.27
Average Path Strength 8.00183
Maximum Path Strength 18.615
Minimum Path Correlation 0.7
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.43902
Average % Of Corr. Nodes 47.7093
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 78.116
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • positive regulation of cell communication   • regulation of localization   • establishment of protein localization   • regulation of cellular process   • nitrogen compound transport   • response to stimulus   • positive regulation of establishment of protein localization   • cell communication   • localization   • carbohydrate homeostasis   • establishment of localization in cell   • positive regulation of insulin secretion involved in cellular response to glucose stimulus   • positive regulation of insulin secretion   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • regulation of biological process   • regulation of hormone levels   • positive regulation of peptide hormone secretion   • establishment of protein localization to extracellular region   • intracellular glucose homeostasis   • protein secretion   • establishment of localization   • cellular response to oxygen-containing compound   • regulation of protein secretion   • regulation of secretion   • cellular response to carbohydrate stimulus   • chemical homeostasis   • response to glucose   • response to chemical   • glucose homeostasis   • positive regulation of protein localization   • insulin secretion involved in cellular response to glucose stimulus   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • signaling   • homeostatic process   • positive regulation of biological process   • positive regulation of secretion by cell   • hormone secretion   • protein localization to extracellular region   • positive regulation of protein transport   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • positive regulation of hormone secretion   • response to monosaccharide   • response to carbohydrate   • positive regulation of secretion   • amide transport   • signal release   • cellular response to hexose stimulus   • intracellular chemical homeostasis   • cellular response to monosaccharide stimulus   • positive regulation of cellular process   • positive regulation of peptide secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • biological regulation   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • response to oxygen-containing compound   • cellular response to glucose stimulus   • regulation of protein transport   • positive regulation of protein secretion   • peptide transport   • response to hexose   • cellular response to chemical stimulus   • cellular homeostasis   • positive regulation of transport   • regulation of cellular localization   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • regulation of insulin secretion involved in cellular response to glucose stimulus   • hormone transport   • regulation of cell communication   • cellular process   • insulin secretion   • positive regulation of signaling   • developmental process   • myeloid leukocyte differentiation   • cellular developmental process   • hemopoiesis   • cell development   • mononuclear cell differentiation   • myeloid cell differentiation   • cell differentiation   • anatomical structure development   • monocyte differentiation   • leukocyte differentiation   • multicellular organismal process   • regulation of leukocyte differentiation   • regulation of cell differentiation   • regulation of cell development   • positive regulation of developmental process   • multicellular organism development   • skeletal system development   • regulation of immune system process   • positive regulation of immune system process   • regulation of osteoclast development   • system development   • positive regulation of cell development   • regulation of myeloid leukocyte differentiation   • osteoclast development   • positive regulation of myeloid leukocyte differentiation   • positive regulation of multicellular organismal process   • regulation of developmental process   • positive regulation of osteoclast differentiation   • regulation of osteoclast differentiation   • positive regulation of cell differentiation   • positive regulation of hemopoiesis   • bone cell development   • osteoclast differentiation   • regulation of multicellular organismal process   • bone development   • positive regulation of osteoclast development   • regulation of multicellular organismal development   • regulation of myeloid cell differentiation   • animal organ development   • immune system process   • myeloid cell development   • positive regulation of myeloid cell differentiation   • regulation of hemopoiesis   • positive regulation of leukocyte differentiation   • defense response   • response to stress   • inflammatory response   • G protein-coupled receptor signaling pathway   • signal transduction   • response to pH   • cellular response to pH   • response to abiotic stimulus   • cellular response to abiotic stimulus   • cellular response to environmental stimulus   • negative regulation of biological process   • negative regulation of cellular process   • negative regulation of cell differentiation   • negative regulation of hemopoiesis   • negative regulation of monocyte differentiation   • regulation of monocyte differentiation   • negative regulation of leukocyte differentiation   • negative regulation of developmental process   • negative regulation of myeloid cell differentiation   • negative regulation of myeloid leukocyte differentiation   • negative regulation of cell development   • negative regulation of immune system process   • negative regulation of multicellular organismal process   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • sensory organ development   • eye development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9BI6_Chain_A
IEKQLQKDK QVYRATHRL LLLGASGKS TIIFETKFQ VDKVNFHMF 
DVGGQRDER RKWIQCFND VTAIIFVVS SYNRLQEAL NFKSIWNNR 
WLRTISVIL FLNKQDLLA EKVLAYFPE FARYTTPPR VTRAKYFIR 
DEFLRISTA SGDGRHYCY PHFTCAVDT ENRRFNDCD IIMLRYLGD 
NDDDAIKLQ NENV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9BI6_Chain_B
IDPVGRIQM RTRRTLRGH LAKIYAMHW GTDSRLLVS ASQDGKLII 
WDSYTTNKV HAIPLRSSW VMTCAYAPS GNYVACGGL DNICSIYNL 
KVRVSRELA GHTGYLSCC RFLDDNQIV TSSGDTTCA LWDIETGQQ 
TTTFTGHTG DVMSLSLAP DTRLFVSGA CDASAKLWD VREGMCRQT 
FTGHESDIN AICFFPNGN AFATGSDDA TCRLFDLRA DQELMTYSH 
DNIICGITS VSFSKSGRL LLAGYDDFN CNVWDALKA DRAGVLAGH 
DNRVSCLGV TDDGMAVAT GSWDSFLKI WN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9BI6_Chain_G
VSKAAADLM AYCEAHAKE DPL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ15743
Sequence
>9BI6_Chain_R
CTIDHTIHQ TLAPVVYVT VLVVGFPAN CLSLYFGYL QIKARNELG 
VYLCNLTVA DLFYICSLP FWLQYVLQH DNWSHGDLS CQVCGILLY 
ENIYISVGF LCCISVDRY LAVAHPFRF HQFRTLKAA VGVSVVIWA 
KELLTSIYF LMHEEVIED ENQHRVCFE HYPIQAWQR AINYYRFLV 
GFLFPICLL LASYQGILR AVRRSHGTQ KSRKDQIQR LVLSTVVIF 
LACFLPYHV LLLVRSVWE ASCDFAKGV FNAYHFSLL LTSFNCVAD 
PVLYCFVSE TTHRDL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9BHMAOrphanOrphanGPR68Homo sapiens--Gs/β12.92025-01-22doi.org/10.1016/j.cell.2024.11.036
9BHM (No Gprot) AOrphanOrphanGPR68Homo sapiens--2.92025-01-22doi.org/10.1016/j.cell.2024.11.036
9BI6AOrphanOrphanGPR68Homo sapiens--chim(Gs-CtGq)/β1/γ22.92025-01-22doi.org/10.1016/j.cell.2024.11.036
9BI6 (No Gprot) AOrphanOrphanGPR68Homo sapiens--2.92025-01-22doi.org/10.1016/j.cell.2024.11.036
8Z3OAOrphanOrphanGPR68Homo sapiens---3.32025-04-23To be published
8Z5HAOrphanOrphanGPR68Homo sapiens--chim(NtGi1-Gs)/β1/γ23.32025-04-23To be published
8Z5H (No Gprot) AOrphanOrphanGPR68Homo sapiens--3.32025-04-23To be published
8Z68AOrphanOrphanGPR68Homo sapiens--chim(NtGi1-Gs)/β1/γ22.642025-04-23To be published
8Z68 (No Gprot) AOrphanOrphanGPR68Homo sapiens--2.642025-04-23To be published




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Download 9BI6.zip



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