Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:I15 5.9175412
2R:R:H20 12.8825414
3R:R:Y28 4.606518
4R:R:V31 3.7375407
5R:R:N39 5.39409
6R:R:L56 5.372537
7R:R:Y59 5.546507
8R:R:L63 3.822599
9R:R:D67 5.64599
10R:R:Y70 4.202506
11R:R:L74 3.0725417
12R:R:W77 7.045416
13R:R:V81 4.255415
14R:R:D85 12.274514
15R:R:W87 9.37519
16R:R:C94 6.195419
17R:R:L101 7.13416
18R:R:Y102 8.29667615
19R:R:N104 4.0125498
20R:R:I107 4.69597
21R:R:F111 7.586597
22R:R:I115 3.9875408
23R:R:R119 6.00167639
24R:R:Y120 4.845438
25R:R:H125 7.8875436
26R:R:P126 5.7475438
27R:R:F127 7.925435
28R:R:R133 4.58537
29R:R:W146 5.185499
30R:R:E149 4.17407
31R:R:F156 6.396514
32R:R:F173 7.46667613
33R:R:Y176 7.015616
34R:R:Q182 5.81571714
35R:R:N186 7.2275414
36R:R:R189 5.69429715
37R:R:F190 6.03416
38R:R:Y205 4.56333638
39R:R:G217 4.5425454
40R:R:R222 8.51254135
41R:R:F237 4.87419
42R:R:F241 6.306519
43R:R:Y244 6.026517
44R:R:H245 10.03518
45R:R:L247 3.7225404
46R:R:R251 8.095415
47R:R:E255 7.8425413
48R:R:F265 8.888513
49R:R:Y268 6.262515
50R:R:L272 5.1325416
51R:R:L273 5.616515
52R:R:L285 4.7325408
53R:R:Y286 5.495439
54R:R:F288 5.2975407
55A:A:N23 10.455467
56A:A:K28 3.21254154
57A:A:L44 9.7725429
58A:A:T55 2.425409
59A:A:I56 5.4775457
60A:A:F219 6.412508
61A:A:M221 3.8854218
62A:A:F222 10.386527
63A:A:V224 7.92429
64A:A:Q227 5.432529
65A:A:R232 7.5875428
66A:A:K233 7.36529
67A:A:W234 7.648529
68A:A:F238 9.32529
69A:A:I244 5.4275428
70A:A:D249 8.5175458
71A:A:S251 4.8725459
72A:A:Y253 9.4975408
73A:A:L270 6.4675406
74A:A:W277 13.394106
75A:A:W281 13.058525
76A:A:I288 4.33559
77A:A:L289 4.57409
78A:A:F290 5.182559
79A:A:L291 5.515408
80A:A:N292 5.466559
81A:A:K293 6.01459
82A:A:F315 9.1254236
83A:A:V334 4.95404
84A:A:Y339 6.53754103
85A:A:F340 10.27254237
86A:A:R342 7.18254104
87A:A:F345 7.925408
88A:A:S349 4.884107
89A:A:C359 3.9085105
90A:A:Y360 9.04571758
91A:A:F363 7.19254105
92A:A:T364 7.102559
93A:A:F376 5.935638
94A:A:R380 6.8437
95A:A:D381 5.658558
96A:A:H387 4.9275438
97A:A:Y391 8.645634
98B:B:M45 4.7375484
99B:B:L51 7.056569
100B:B:H54 10.132569
101B:B:K57 12.9429
102B:B:I58 6.125469
103B:B:Y59 5.42428
104B:B:W63 6.00714707
105B:B:S72 6.015469
106B:B:Q75 8.9725429
107B:B:D76 5.381676209
108B:B:K78 4.7125408
109B:B:I80 7.4675468
110B:B:W82 9.71333669
111B:B:D83 9.44468
112B:B:N88 6.094567
113B:B:K89 7.896569
114B:B:V90 4.3325465
115B:B:L95 8.08754258
116B:B:W99 12.434529
117B:B:M101 4.912529
118B:B:Y105 5.4225406
119B:B:Y111 3.60754164
120B:B:I123 4.09754166
121B:B:Y124 4.62833606
122B:B:H142 7.2285119
123B:B:Y145 7.19667628
124B:B:L146 3.71754117
125B:B:C149 4.075118
126B:B:F151 5.07167609
127B:B:L152 8.065443
128B:B:N155 6.665443
129B:B:Q156 8.585445
130B:B:I157 5.28254117
131B:B:V158 4.29445
132B:B:T159 5.636676119
133B:B:S160 4.4475446
134B:B:D163 5.4425409
135B:B:C166 4.0475448
136B:B:L168 5.144546
137B:B:W169 7.441676118
138B:B:Q176 4.99254114
139B:B:F180 8.806547
140B:B:H183 9.21649
141B:B:D186 6.5675429
142B:B:V187 5.5475449
143B:B:M188 6.3428
144B:B:L190 4.3445
145B:B:L198 4.2175403
146B:B:F199 7.114549
147B:B:S201 6.42449
148B:B:C204 4.32527
149B:B:D205 6.478549
150B:B:K209 11.976546
151B:B:W211 8.04429748
152B:B:H225 9.13571779
153B:B:D228 9.5075429
154B:B:I232 3.584578
155B:B:F235 7.84754176
156B:B:F241 4.3776
157B:B:T243 6.055478
158B:B:D247 7.968579
159B:B:T249 6.0575476
160B:B:R251 10.535678
161B:B:F253 5.63286776
162B:B:H266 5.74254124
163B:B:F278 7.2385177
164B:B:L284 3.6175485
165B:B:L286 5.0025487
166B:B:Y289 8.2425127
167B:B:D290 5.815426
168B:B:V296 3.44485
169B:B:W297 10.2025128
170B:B:K301 4.72254145
171B:B:L308 4.77487
172B:B:H311 9.89589
173B:B:R314 14.728528
174B:B:L318 5.08406
175B:B:T321 5.2125247
176B:B:W332 12.9217629
177B:B:D333 7.2575489
178B:B:F335 5.9775404
179B:B:L336 4.308567
180B:B:K337 9.0325486
181B:B:W339 6.60333689
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:Y244 R:R:Y268 11.60183.97YesYes175
2R:R:H245 R:R:Y244 12.48366.53YesYes187
3R:R:F241 R:R:H245 25.25127.92YesYes198
4R:R:C279 R:R:Y70 37.01275.38NoYes086
5R:R:C279 R:R:D67 37.58276.22NoYes089
6R:R:L101 R:R:Y102 17.703111.72YesYes165
7R:R:L101 R:R:Y70 28.01394.69YesYes066
8R:R:F237 R:R:F241 25.67493.22YesYes199
9R:R:F237 R:R:L201 28.57957.31YesNo098
10R:R:L201 R:R:S116 29.42684.5NoNo089
11R:R:S116 R:R:Y205 30.01773.82NoYes098
12R:R:R119 R:R:Y205 34.66836.17YesYes398
13R:R:D67 R:R:L63 45.02554.07YesYes999
14R:R:I115 R:R:L63 51.06692.85YesYes089
15A:A:Y391 R:R:R119 88.59844.12YesYes349
16R:R:Q182 R:R:R189 11.48453.5YesYes145
17A:A:Y391 R:R:A122 48.64199.34YesNo348
18A:A:H387 R:R:A122 48.76414.39YesNo388
19A:A:H387 R:R:P126 97.86953.05YesYes388
20A:A:R380 R:R:P126 98.01338.65YesYes378
21A:A:Y391 R:R:R133 48.6915.14YesYes347
22A:A:H387 R:R:R133 49.05795.64YesYes387
23A:A:I375 A:A:L43 99.80942.85NoNo097
24A:A:L43 A:A:M221 99.84164.24NoYes078
25A:A:F212 A:A:M221 99.93713.73NoYes098
26A:A:F212 A:A:F219 10010.72NoYes098
27A:A:F219 A:A:H41 49.90266.79YesNo086
28A:A:H41 R:R:F127 49.911912.44NoYes065
29A:A:R380 R:R:F127 97.65128.55YesYes375
30A:A:F290 A:A:I375 96.29163.77YesNo099
31A:A:F219 A:A:F376 50.126.43YesYes088
32A:A:F376 R:R:F127 50.01456.43YesYes385
33B:B:I80 B:B:K78 21.28445.82YesYes088
34B:B:D76 B:B:K78 22.54234.15YesYes098
35A:A:Y37 B:B:D76 50.08424.6NoYes2049
36A:A:R42 A:A:Y37 50.849421.61NoNo094
37A:A:F222 A:A:R42 51.81724.28YesNo079
38A:A:F222 B:B:W99 53.005225.05YesYes279
39A:A:F238 B:B:W99 52.200414.03YesYes299
40A:A:F238 A:A:L44 26.500720.7YesYes299
41A:A:I244 A:A:L44 26.627211.42YesYes289
42A:A:I244 A:A:V287 32.90613.07YesNo086
43A:A:C359 A:A:V287 32.9813.42YesNo056
44A:A:C359 A:A:L289 32.85293.17YesYes059
45A:A:L289 A:A:L291 88.60284.15YesYes098
46A:A:I341 A:A:L291 90.57524.28NoYes088
47A:A:I341 A:A:S250 90.62517.74NoNo086
48A:A:L297 A:A:S250 90.72619.01NoNo086
49A:A:L297 A:A:S251 93.55344.5NoYes089
50A:A:K293 A:A:S251 93.02633.06YesYes599
51A:A:K293 A:A:N292 93.72386.99YesYes599
52A:A:N292 A:A:T364 94.05545.85YesYes599
53A:A:F290 A:A:T364 94.78529.08YesYes599
54A:A:F238 A:A:W234 27.44014.01YesYes299
55A:A:R231 A:A:W234 56.5884NoYes099
56A:A:L272 A:A:R231 56.66117.29NoNo089
57A:A:F246 A:A:L272 56.73456.09NoNo098
58A:A:F246 A:A:L289 56.8914.87NoYes099
59A:A:W234 B:B:Y145 32.3747.72YesYes298
60B:B:D186 B:B:Y145 31.33323.45YesYes298
61A:A:R228 B:B:D186 30.649811.91NoYes299
62A:A:R228 B:B:T164 30.63833.88NoNo096
63B:B:M45 B:B:N340 21.71715.61YesNo049
64B:B:N340 B:B:R48 22.21054.82NoNo097
65B:B:R48 B:B:R49 23.19772.13NoNo077
66B:B:R49 B:B:Y85 23.69443.09NoNo074
67B:B:M325 B:B:Y85 24.19852.39NoNo054
68B:B:D323 B:B:M325 24.702912.48NoNo075
69B:B:D323 B:B:T321 25.19747.23NoYes2477
70B:B:T321 B:B:W63 28.24112.13YesYes077
71B:B:L70 B:B:W63 30.211410.25NoYes057
72B:B:L70 B:B:W82 30.70045.69NoYes659
73B:B:H54 B:B:W82 16.29358.46YesYes699
74B:B:H54 B:B:S74 19.414311.16YesNo099
75B:B:D76 B:B:S74 19.665910.31YesNo099
76B:B:I80 B:B:W82 16.323911.74YesYes689
77B:B:C148 B:B:T102 22.85183.38NoNo068
78B:B:C149 B:B:T102 23.10953.38YesNo088
79B:B:C149 B:B:L146 11.51073.17YesYes1187
80B:B:H142 B:B:L146 11.75383.86YesYes1197
81B:B:H142 B:B:S161 29.98049.76YesNo099
82B:B:D163 B:B:S161 30.08844.42YesNo099
83B:B:D163 B:B:T164 30.52234.34YesNo096
84B:B:C149 B:B:T159 11.56235.07YesYes1189
85B:B:H142 B:B:T159 14.14778.21YesYes1199
86B:B:C148 B:B:L190 21.79176.35NoYes065
87B:B:L152 B:B:V158 13.61335.96YesYes435
88B:B:L190 B:B:V158 13.82612.98YesYes455
89B:B:L152 B:B:L168 10.97224.15YesYes436
90B:B:L168 B:B:V213 10.71832.98YesNo064
91B:B:D212 B:B:V213 10.46682.92NoNo094
92R:R:I115 R:R:R119 50.87673.76YesYes089
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9BHM
Class A
SubFamily Orphan
Type Orphan
SubType GPR68
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1
PDB Resolution 2.9
Date 2025-01-22
D.O.I. doi.org/10.1016/j.cell.2024.11.036
Net Summary
Imin 2.85
Number of Linked Nodes 748
Number of Links 966
Number of Hubs 181
Number of Links mediated by Hubs 626
Number of Communities 26
Number of Nodes involved in Communities 284
Number of Links involved in Communities 424
Path Summary
Number Of Nodes in MetaPath 93
Number Of Links MetaPath 92
Number of Shortest Paths 1686506
Length Of Smallest Path 3
Average Path Length 39.9536
Length of Longest Path 69
Minimum Path Strength 1.27
Average Path Strength 6.53158
Maximum Path Strength 26.99
Minimum Path Correlation 0.7
Average Path Correlation 0.981535
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.22222
Average % Of Corr. Nodes 34.6101
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 61.2268
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ15743
Sequence
>9BHM_Chain_R
CTIDHTIHQ TLAPVVYVT VLVVGFPAN CLSLYFGYL QIKARNELG 
VYLCNLTVA DLFYICSLP FWLQYVLQH DNWSHGDLS CQVCGILLY 
ENIYISVGF LCCISVDRY LAVAHPFRF HQFRTLKAA VGVSVVIWA 
KELLTSIYF LMHEEVIED ENQHRVCFE HYPIQAWQR AINYYRFLV 
GFLFPICLL LASYQGILR AVRRSHGTQ KSRKDQIQR LVLSTVVIF 
LACFLPYHV LLLVRSVWE ASCDFAKGV FNAYHFSLL LTSFNCVAD 
PVLYCFVSE TTH


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9BHM_Chain_A
EKAQREANK KIEKQLQKD KQVYRATHR LLLLGASGK STIVKGIFE 
TKFQVDKVN FHMFDVGGQ RDERRKWIQ CFNDVTAII FVVSSYNRL 
QEALNLFKS IWNNRWLRT ISVILFLNK QDLLAEKVL AGKSKIEDY 
FPEFARYTT DPRVTRAKY FIRDEFLRI STASGRHYC YPHFTCAVD 
TENRRFNDC RDIIQRMHL RQYELLDND DAI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9BHM_Chain_B
GRIQMRTRR TLRGHLAKI YAMHWGTDS RLLVSASQD GKLIIWDSY 
TTNKVHAIP LRSSWVMTC AYAPSGNYV ACGGLDNIC SIYNLKVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LELMTYSHD NIICGITSV 
SFSKSGRLL LAGYDDFNC NVWDALKAD RAGVLAGHD NRVSCLGVT 
DDGMAVATG SWDSFLKIW N


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9BHMAOrphanOrphanGPR68Homo sapiens--Gs/β12.92025-01-22doi.org/10.1016/j.cell.2024.11.036
9BHM (No Gprot) AOrphanOrphanGPR68Homo sapiens--2.92025-01-22doi.org/10.1016/j.cell.2024.11.036
9BI6AOrphanOrphanGPR68Homo sapiens--chim(Gs-CtGq)/β1/γ22.92025-01-22doi.org/10.1016/j.cell.2024.11.036
9BI6 (No Gprot) AOrphanOrphanGPR68Homo sapiens--2.92025-01-22doi.org/10.1016/j.cell.2024.11.036
8Z3OAOrphanOrphanGPR68Homo sapiens---3.32025-04-23To be published
8Z5HAOrphanOrphanGPR68Homo sapiens--chim(NtGi1-Gs)/β1/γ23.32025-04-23To be published
8Z5H (No Gprot) AOrphanOrphanGPR68Homo sapiens--3.32025-04-23To be published
8Z68AOrphanOrphanGPR68Homo sapiens--chim(NtGi1-Gs)/β1/γ22.642025-04-23To be published
8Z68 (No Gprot) AOrphanOrphanGPR68Homo sapiens--2.642025-04-23To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9BHM.zip



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