Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:D16 4.8225405
2A:A:K34 5.4225404
3A:A:H41 6.0225426
4A:A:L43 3.045427
5A:A:L46 3.435408
6A:A:T55 2.6725409
7A:A:M60 3.4375429
8A:A:F212 5.78429
9A:A:V214 4.02526
10A:A:V217 4.9525425
11A:A:F219 5.595628
12A:A:M221 2.496528
13A:A:R231 6.78409
14A:A:K233 5.81167679
15A:A:F238 10.0825409
16A:A:V248 3.5075407
17A:A:S250 5.63254116
18A:A:D252 4.774168
19A:A:R265 6.2554169
20A:A:L270 4.8625406
21A:A:F273 4.78754259
22A:A:W277 9.45754256
23A:A:N279 3.934248
24A:A:W281 5.8775405
25A:A:L289 4.225409
26A:A:F290 4.734179
27A:A:L291 4.1565118
28A:A:Q294 4.9085116
29A:A:L297 3.044118
30A:A:V301 2.2425407
31A:A:F315 9.7425406
32A:A:F340 6.2145157
33A:A:D343 6.32254153
34A:A:E344 7.2754155
35A:A:F345 7.145408
36A:A:Y360 7.9854268
37A:A:N371 6.9085179
38A:A:R374 7.60254174
39A:A:F376 5.482528
40A:A:D378 8.554267
41A:A:I382 5.22254266
42A:A:R385 3.11505
43A:A:H387 4.645418
44A:A:Y391 7.948514
45A:A:E392 4.47254286
46B:B:R22 5.9854126
47B:B:H54 7.1475489
48B:B:K57 7.60754189
49B:B:M61 3.5175406
50B:B:S74 6.22489
51B:B:L79 3.36754207
52B:B:N88 5.55407
53B:B:K89 4.728589
54B:B:L95 4.4065208
55B:B:W99 9.5775409
56B:B:Y105 3.545406
57B:B:I120 3.07754216
58B:B:I123 3.3525406
59B:B:Y124 3.756206
60B:B:H142 5.932599
61B:B:Y145 4.888508
62B:B:F151 5.1525409
63B:B:L152 3.865403
64B:B:T165 2.915497
65B:B:W169 6.335698
66B:B:F180 6.58254107
67B:B:H183 4.4154109
68B:B:D186 6.042579
69B:B:V187 4.125409
70B:B:M188 4.4375478
71B:B:C204 4.3725477
72B:B:K209 5.9354106
73B:B:W211 8.38254108
74B:B:H225 8.385139
75B:B:D228 5.374579
76B:B:I232 4.3425408
77B:B:F235 5.72333636
78B:B:P236 6.3775437
79B:B:T243 6.55754138
80B:B:R251 8.625408
81B:B:L252 2.0425407
82B:B:F253 5.88754136
83B:B:Y264 5.7875435
84B:B:I273 4.105406
85B:B:V276 3.6406
86B:B:F278 3.67333637
87B:B:R283 8.845199
88B:B:L285 3.3925436
89B:B:Y289 5.78667637
90B:B:N295 9.2075436
91B:B:R304 3.8925435
92B:B:H311 84309
93B:B:R314 10.2675408
94B:B:T329 4.8375408
95B:B:W332 9.548336189
96B:B:D333 11.294309
97B:B:F335 5.4175404
98B:B:K337 3.58406
99G:G:L51 4.6125406
100G:G:V54 3.22446
101G:G:N59 6.815449
102G:G:P60 6.465449
103G:G:F61 5.38857748
104R:R:I15 6.5175452
105R:R:H17 7.705454
106R:R:N39 4.624509
107R:R:F45 4.63406
108R:R:Q49 2.7785284
109R:R:Y59 7.89417
110R:R:L63 3.735469
111R:R:D67 5.5775469
112R:R:Y70 6.334506
113R:R:L74 2.325407
114R:R:W77 6.93506
115R:R:D85 14.8475454
116R:R:W87 6.7775409
117R:R:Y102 7.166505
118R:R:Y106 7.514327
119R:R:I107 5.16467
120R:R:F111 6.27567
121R:R:D118 6.7575418
122R:R:R119 5.3975419
123R:R:Y120 4.2654338
124R:R:W146 4.395469
125R:R:F156 4.8275404
126R:R:H169 9.61452
127R:R:F173 7.886503
128R:R:F194 7.494148
129R:R:Y205 6.86518
130R:R:L209 1.7125405
131R:R:F237 4.84254149
132R:R:F241 4.9856149
133R:R:L242 4.0854144
134R:R:Y244 6.9825407
135R:R:H245 7.5725408
136R:R:F265 8.372553
137R:R:Y268 9.4425405
138R:R:D282 8.42469
139R:R:Y286 4.9175419
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D66 B:B:R68 12.52682.38NoNo085
2B:B:D66 B:B:L69 12.199412.21NoNo085
3B:B:L69 B:B:Y105 11.87193.52NoYes056
4B:B:R68 B:B:Y85 16.012420.58NoNo054
5B:B:Y85 G:G:F61 16.25227.22NoYes448
6B:B:W63 G:G:F61 26.64663.01NoYes478
7B:B:L70 B:B:W63 27.94336.83NoNo057
8B:B:L70 B:B:M61 28.26324.24NoYes056
9B:B:C317 B:B:M61 29.22594.86NoYes076
10B:B:C317 B:B:S316 29.54693.44NoNo079
11B:B:S316 B:B:W332 29.86864.94NoYes099
12B:B:R314 B:B:W332 25.695715.99YesYes089
13A:A:W281 B:B:R314 49.29898YesYes058
14A:A:N279 A:A:W281 73.31093.39YesYes085
15A:A:I235 A:A:N279 73.52944.25NoYes2498
16A:A:I235 A:A:R231 73.80963.76NoYes099
17A:A:D272 A:A:R231 97.623210.72NoYes099
18A:A:D272 A:A:F246 1008.36NoNo099
19A:A:F246 A:A:V248 49.54412.62NoYes097
20A:A:L291 A:A:V248 49.23454.47YesYes087
21A:A:L291 A:A:S250 49.8546.01YesYes1186
22A:A:L297 A:A:S250 49.52153YesYes1186
23A:A:L297 A:A:Y253 97.16553.52YesNo088
24A:A:Y253 A:A:Y311 97.70262.98NoNo086
25A:A:N264 A:A:Y311 97.41125.81NoNo096
26A:A:D252 A:A:N264 97.26534.04YesNo089
27A:A:D249 A:A:D252 96.38762.66NoYes088
28A:A:D249 A:A:K293 95.26038.3NoNo089
29A:A:K293 A:A:N292 94.88264.2NoNo099
30A:A:N292 A:A:V247 94.73474.43NoNo097
31A:A:F290 A:A:V247 94.58672.62YesNo097
32A:A:F290 A:A:I288 89.35473.77YesNo099
33A:A:D378 A:A:I288 89.05511.2YesNo079
34A:A:N239 B:B:W332 23.64732.26NoYes089
35A:A:N239 A:A:W281 23.78952.26NoYes085
36A:A:F246 A:A:L289 50.56063.65NoYes099
37A:A:L289 A:A:L291 50.4182.77YesYes098
38A:A:L291 A:A:Q294 49.59622.66YesYes1186
39A:A:L297 A:A:Q294 49.52112.66YesYes1186
40A:A:V224 A:A:W234 24.984212.26NoNo099
41A:A:Q227 A:A:V224 23.97032.87NoNo099
42A:A:Q227 B:B:Y145 23.46173.38NoYes098
43A:A:K233 B:B:Y145 10.92274.78YesYes098
44A:A:D378 A:A:I382 12.50168.4YesYes2676
45A:A:D378 A:A:Y360 74.635311.49YesYes2678
46A:A:R385 A:A:Y360 74.04884.12YesYes058
47A:A:I382 A:A:M386 12.25451.46YesNo063
48A:A:I383 A:A:M386 12.12481.46NoNo083
49A:A:H387 A:A:I383 11.24866.63YesNo188
50A:A:R385 A:A:R389 73.29273.2YesNo054
51A:A:L394 A:A:R389 73.13363.64NoNo084
52A:A:L394 R:R:I226 69.81362.85NoNo087
53A:A:L393 R:R:I226 69.65362.85NoNo087
54A:A:L393 R:R:R119 69.49486.07NoYes089
55B:B:D290 B:B:R314 26.960611.91NoYes068
56B:B:C271 B:B:D290 26.64516.22NoNo056
57B:B:C271 B:B:Y289 26.15194.03NoYes357
58B:B:W297 B:B:Y289 15.99815.79NoYes387
59B:B:L285 B:B:W297 13.98273.42YesNo368
60B:B:F278 B:B:L285 13.5983.65YesYes376
61B:B:G330 B:B:I58 10.17623.53NoNo059
62B:B:G330 B:B:T329 10.49573.64NoYes058
63B:B:H311 B:B:T329 14.32465.48YesYes098
64B:B:G162 B:B:Y145 10.77035.79NoYes098
65B:B:G162 B:B:S161 10.41453.71NoNo099
66B:B:D333 B:B:H311 18.862711.35YesYes3099
67B:B:D312 B:B:D333 21.460410.65NoYes059
68B:B:D312 B:B:N313 21.78434.04NoNo057
69R:R:R119 R:R:Y286 47.25664.12YesYes199
70R:R:L112 R:R:Y286 46.59528.21NoYes089
71R:R:D282 R:R:L112 46.42375.43YesNo098
72R:R:D282 R:R:D67 32.67246.65YesYes699
73R:R:C279 R:R:D67 29.16466.22NoYes089
74R:R:C279 R:R:Y70 28.95615.38NoYes086
75R:R:L101 R:R:Y70 25.71734.69NoYes066
76R:R:L101 R:R:Y102 19.44057.03NoYes065
77R:R:F265 R:R:H269 14.339923.76YesNo034
78R:R:D282 R:R:N278 11.642114.81YesNo099
79R:R:R119 R:R:Y205 22.22025.14YesYes198
80R:R:S116 R:R:Y205 21.529212.72NoYes198
81R:R:L201 R:R:S116 21.39293NoNo089
82R:R:F237 R:R:L201 21.23693.65YesNo098
83R:R:H245 R:R:Y106 12.10116.53YesYes087
84R:R:E103 R:R:Y106 10.7285.61NoYes3257
85R:R:F237 R:R:F241 10.97517.5YesYes1499
86R:R:F241 R:R:H245 13.06333.39YesYes098
87R:R:F241 R:R:N278 11.33213.62YesNo099
88R:R:W181 R:R:Y155 11.39452.89NoNo038
89B:B:N313 B:B:W332 22.43183.39NoYes079
90A:A:R231 A:A:W234 25.04649YesNo099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8Z5H
Class A
SubFamily Orphan
Type Orphan
SubType GPR68
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 3.3
Date 2025-04-23
D.O.I. To be published
Net Summary
Imin 2.62
Number of Linked Nodes 846
Number of Links 975
Number of Hubs 139
Number of Links mediated by Hubs 496
Number of Communities 33
Number of Nodes involved in Communities 196
Number of Links involved in Communities 254
Path Summary
Number Of Nodes in MetaPath 91
Number Of Links MetaPath 90
Number of Shortest Paths 2013176
Length Of Smallest Path 3
Average Path Length 38.9611
Length of Longest Path 66
Minimum Path Strength 1.335
Average Path Strength 5.55204
Maximum Path Strength 17.42
Minimum Path Correlation 0.71
Average Path Correlation 0.986087
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.32558
Average % Of Corr. Nodes 36.4327
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 44.6651
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8Z5H_Chain_A
EKAEKIEKQ LQKDKQVYR ATHRLLLLG ASGKSTIVK QMRIHVTSG 
IFETKFQVD KVNFHMFDV GQRDERRKW IQCFNDVTA IIFVVSSYN 
RLQEALNFK SIWNNRWLR TISVILFLN KQDLLAEKV LAGKSKIED 
YFPEFARYT TPEDATPEP GEDPRVTRA KYFIRDEFL RISTASGDG 
RHYCYPHFT CVDTENRRF NDCRDIIQR MHLRQYELL LSADAVRSM 
DNYKADDDS AI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8Z5H_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8Z5H_Chain_G
QARKLVEQL KMEANIDRI KVSKAAADL MAYCEAHAK EDPLLTPVP 
ASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ15743
Sequence
>8Z5H_Chain_R
SCTIDHTIH QTLAPVVYV TVLVVGFPA NCLSLYFGY LQIKARNEL 
GVYLCNLTV ADLFYICSL PFWLQYVLQ HDNWSHGDL SCQVCGILL 
YENIYISVG FLCCISVDR YLAVAHPFR FHQFRTLKA AVGVSVVIW 
AKELLTSIY FLMHEEVIE DENQHRVCF EHYPIQAWQ RAINYYRFL 
VGFLFPICL LLASYQGIL RAVRRSHGT QKSRKDQIQ RLVLSTVVI 
FLACFLPYH VLLLVRSVW EASCDFAKG VFNAYHFSL LLTSFNCVA 
DPVLYCFVS ETTHRDL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9BHMAOrphanOrphanGPR68Homo sapiens--Gs/β12.92025-01-22doi.org/10.1016/j.cell.2024.11.036
9BHM (No Gprot) AOrphanOrphanGPR68Homo sapiens--2.92025-01-22doi.org/10.1016/j.cell.2024.11.036
9BI6AOrphanOrphanGPR68Homo sapiens--chim(Gs-CtGq)/β1/γ22.92025-01-22doi.org/10.1016/j.cell.2024.11.036
9BI6 (No Gprot) AOrphanOrphanGPR68Homo sapiens--2.92025-01-22doi.org/10.1016/j.cell.2024.11.036
8Z3OAOrphanOrphanGPR68Homo sapiens---3.32025-04-23To be published
8Z5HAOrphanOrphanGPR68Homo sapiens--chim(NtGi1-Gs)/β1/γ23.32025-04-23To be published
8Z5H (No Gprot) AOrphanOrphanGPR68Homo sapiens--3.32025-04-23To be published
8Z68AOrphanOrphanGPR68Homo sapiens--chim(NtGi1-Gs)/β1/γ22.642025-04-23To be published
8Z68 (No Gprot) AOrphanOrphanGPR68Homo sapiens--2.642025-04-23To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8Z5H.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.