psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C13	R:R:P177	9.41	No	No	0	7	4
2	R:R:C13	R:R:C258	7.28	No	No	0	7	5
3	R:R:E166	R:R:T14	5.64	No	No	0	3	3
4	R:R:I15	R:R:Y176	10.88	No	Yes	2	2	6
5	R:R:F265	R:R:I15	3.77	Yes	No	2	3	2
6	R:R:H17	R:R:H84	9.55	No	No	0	4	3
7	R:R:D85	R:R:H17	21.43	No	No	0	4	4
8	R:R:I19	R:R:N266	5.66	No	No	0	3	1
9	R:R:H20	R:R:V81	5.54	Yes	No	0	4	5
10	R:R:D85	R:R:H20	15.13	No	Yes	0	4	4
11	R:R:F265	R:R:H20	5.66	Yes	Yes	2	3	4
12	R:R:H20	R:R:H269	14.33	Yes	Yes	2	4	4
13	R:R:H84	R:R:Q21	13.6	No	No	0	3	4
14	R:R:L23	R:R:T22	4.42	No	No	0	5	3
15	R:R:L273	R:R:V27	7.45	Yes	No	0	5	5
16	R:R:F277	R:R:V27	3.93	No	No	0	4	5
17	R:R:L74	R:R:Y28	7.03	No	No	0	7	8
18	R:R:V81	R:R:Y28	3.79	No	No	0	5	8
19	R:R:L273	R:R:Y28	4.69	Yes	No	0	5	8
20	R:R:L78	R:R:V29	4.47	No	No	0	7	6
21	R:R:S276	R:R:V31	6.46	No	No	0	7	7
22	R:R:L32	R:R:P75	6.57	No	No	0	6	9
23	R:R:F36	R:R:P37	4.33	No	No	0	6	5
24	R:R:F36	R:R:I71	5.02	No	No	0	6	5
25	R:R:N39	R:R:T64	5.85	No	No	0	9	8
26	R:R:D67	R:R:N39	10.77	Yes	No	0	9	9
27	R:R:N39	R:R:P283	13.03	No	No	0	9	9
28	R:R:S42	R:R:T64	7.99	No	No	0	8	8
29	R:R:C287	R:R:S42	6.89	No	No	0	6	8
30	R:R:L43	R:R:T64	4.42	No	No	0	6	8
31	R:R:F45	R:R:Y44	7.22	Yes	No	0	6	4
32	R:R:L48	R:R:Y44	16.41	No	No	0	4	4
33	R:R:C287	R:R:F45	4.19	No	Yes	0	6	6
34	R:R:F45	R:R:T293	7.78	Yes	No	0	6	8
35	R:R:N54	R:R:Q49	10.56	No	No	0	7	4
36	R:R:L56	R:R:N54	4.12	No	No	0	7	7
37	R:R:E55	R:R:Y59	5.61	Yes	Yes	1	6	7
38	R:R:D118	R:R:E55	11.69	No	Yes	1	8	6
39	R:R:E55	R:R:R133	5.82	Yes	Yes	1	6	7
40	R:R:A138	R:R:E55	4.53	No	Yes	1	7	6
41	R:R:L56	R:R:L60	5.54	No	No	0	7	7
42	R:R:I115	R:R:L56	4.28	Yes	No	0	8	7
43	R:R:A138	R:R:V58	5.09	No	Yes	0	7	6
44	R:R:C114	R:R:Y59	6.72	No	Yes	0	6	7
45	R:R:D118	R:R:Y59	12.64	No	Yes	1	8	7
46	R:R:A138	R:R:Y59	5.34	No	Yes	1	7	7
47	R:R:V141	R:R:Y59	5.05	No	Yes	0	4	7
48	R:R:F111	R:R:N62	14.5	Yes	No	5	7	9
49	R:R:N62	R:R:S142	7.45	No	No	5	9	6
50	R:R:N62	R:R:W146	5.65	No	Yes	5	9	9
51	R:R:D67	R:R:L63	5.43	Yes	No	1	9	9
52	R:R:D282	R:R:L63	12.21	Yes	No	1	9	9
53	R:R:F69	R:R:V65	3.93	No	No	0	7	5
54	R:R:D67	R:R:S108	4.42	Yes	No	0	9	9
55	R:R:C279	R:R:D67	6.22	No	Yes	0	8	9
56	R:R:D282	R:R:D67	6.65	Yes	Yes	1	9	9
57	R:R:F69	R:R:W146	4.01	No	Yes	0	7	9
58	R:R:L74	R:R:Y70	5.86	No	Yes	0	7	6
59	R:R:L101	R:R:Y70	8.21	No	Yes	0	6	6
60	R:R:S276	R:R:Y70	7.63	No	Yes	0	7	6
61	R:R:C279	R:R:Y70	5.38	No	Yes	0	8	6
62	R:R:L100	R:R:S73	9.01	No	No	0	5	6
63	R:R:C97	R:R:F76	5.59	Yes	No	0	5	6
64	R:R:W77	R:R:Y80	5.79	Yes	No	0	6	5
65	R:R:C97	R:R:W77	3.92	Yes	Yes	0	5	6
66	R:R:G98	R:R:W77	4.22	No	Yes	0	5	6
67	R:R:L101	R:R:W77	19.36	No	Yes	0	6	6
68	R:R:C172	R:R:W77	5.22	No	Yes	0	9	6
69	R:R:L82	R:R:Q79	5.32	No	No	0	4	4
70	R:R:Q79	R:R:Q83	12.8	No	No	0	4	4
71	R:R:D85	R:R:Y80	17.24	No	No	0	4	5
72	R:R:W87	R:R:Y80	9.65	Yes	No	0	9	5
73	R:R:N86	R:R:Q83	5.28	Yes	No	0	4	4
74	R:R:H169	R:R:H84	15.53	Yes	No	0	2	3
75	R:R:N86	R:R:S88	8.94	Yes	No	0	4	3
76	R:R:H169	R:R:N86	3.83	Yes	Yes	0	2	4
77	R:R:C94	R:R:W87	7.84	No	Yes	6	9	9
78	R:R:C97	R:R:W87	6.53	Yes	Yes	0	5	9
79	R:R:C172	R:R:W87	10.45	No	Yes	6	9	9
80	R:R:C172	R:R:C94	7.28	No	No	6	9	9
81	R:R:L157	R:R:Q95	5.32	No	No	0	4	7
82	R:R:E161	R:R:Q95	10.19	No	No	0	4	7
83	R:R:F173	R:R:G98	9.03	No	No	0	3	5
84	R:R:E103	R:R:I99	16.4	Yes	No	3	5	5
85	R:R:I99	R:R:S153	4.64	No	No	3	5	6
86	R:R:F156	R:R:I99	7.54	Yes	No	3	4	5
87	R:R:L100	R:R:N104	5.49	No	No	0	5	8
88	R:R:L101	R:R:Y102	8.21	No	Yes	0	6	5
89	R:R:E174	R:R:Y102	11.22	No	Yes	2	5	5
90	R:R:Y102	R:R:Y268	3.97	Yes	Yes	2	5	5
91	R:R:L272	R:R:Y102	8.21	No	Yes	0	6	5
92	R:R:E103	R:R:T152	14.11	Yes	No	0	5	4
93	R:R:E103	R:R:S153	7.19	Yes	No	3	5	6
94	R:R:E103	R:R:F156	11.66	Yes	Yes	3	5	4
95	R:R:I105	R:R:Y106	8.46	No	No	0	7	7
96	R:R:F241	R:R:I105	5.02	Yes	No	0	9	7
97	R:R:R189	R:R:Y106	10.29	No	No	0	5	7
98	R:R:H245	R:R:Y106	10.89	Yes	No	0	8	7
99	R:R:I107	R:R:W146	5.87	No	Yes	0	7	9
100	R:R:I107	R:R:K148	5.82	No	No	0	7	4
101	R:R:F237	R:R:V109	6.55	Yes	Yes	1	9	7
102	R:R:F241	R:R:V109	6.55	Yes	Yes	1	9	7
103	R:R:F111	R:R:S142	3.96	Yes	No	5	7	6
104	R:R:F111	R:R:I145	12.56	Yes	No	0	7	6
105	R:R:F111	R:R:W146	7.02	Yes	Yes	5	7	9
106	R:R:L112	R:R:L201	4.15	Yes	No	1	8	8
107	R:R:F237	R:R:L112	4.87	Yes	Yes	1	9	8
108	R:R:D282	R:R:L112	4.07	Yes	Yes	1	9	8
109	R:R:L112	R:R:Y286	5.86	Yes	Yes	1	8	9
110	R:R:C113	R:R:P197	3.77	No	Yes	0	7	9
111	R:R:C113	R:R:L200	4.76	No	No	0	7	6
112	R:R:I115	R:R:R119	5.01	Yes	No	1	8	9
113	R:R:I115	R:R:Y286	7.25	Yes	Yes	1	8	9
114	R:R:L201	R:R:S116	4.5	No	No	0	8	9
115	R:R:S116	R:R:S204	6.52	No	No	0	9	6
116	R:R:S116	R:R:Y205	6.36	No	Yes	0	9	8
117	R:R:L200	R:R:V117	4.47	No	No	0	6	5
118	R:R:D118	R:R:R133	5.96	No	Yes	1	8	7
119	R:R:R119	R:R:Y205	6.17	No	Yes	0	9	8
120	R:R:R119	R:R:Y286	6.17	No	Yes	1	9	9
121	R:R:A124	R:R:Y120	6.67	No	Yes	0	7	8
122	R:R:H125	R:R:Y120	7.62	No	Yes	0	6	8
123	R:R:F129	R:R:L121	4.87	Yes	No	0	6	5
124	R:R:A122	R:R:R133	4.15	No	Yes	0	8	7
125	R:R:I208	R:R:V123	4.61	No	No	0	8	8
126	R:R:F129	R:R:H125	9.05	Yes	No	0	6	6
127	R:R:F129	R:R:R128	11.76	Yes	No	0	6	4
128	R:R:F129	R:R:F132	5.36	Yes	No	0	6	3
129	R:R:F132	R:R:Q131	12.88	No	No	0	3	4
130	R:R:E149	R:R:W146	5.45	No	Yes	0	7	9
131	R:R:E149	R:R:L150	3.98	No	No	0	7	4
132	R:R:E149	R:R:S153	8.62	No	No	0	7	6
133	R:R:H159	R:R:Y155	14.16	No	No	3	4	8
134	R:R:W181	R:R:Y155	4.82	Yes	No	3	3	8
135	R:R:F156	R:R:F173	6.43	Yes	No	0	4	3
136	R:R:F156	R:R:W181	4.01	Yes	Yes	3	4	3
137	R:R:F156	R:R:I185	3.77	Yes	No	0	4	5
138	R:R:H159	R:R:W181	26.45	No	Yes	3	4	3
139	R:R:E161	R:R:F173	17.49	No	No	0	4	3
140	R:R:R170	R:R:V162	9.15	Yes	No	0	4	5
141	R:R:I163	R:R:V171	4.61	No	No	0	1	3
142	R:R:H175	R:R:I163	7.95	No	No	0	4	1
143	R:R:D165	R:R:E166	10.39	No	No	4	2	3
144	R:R:D165	R:R:N167	4.04	No	Yes	4	2	4
145	R:R:D165	R:R:H169	11.35	No	Yes	4	2	2
146	R:R:E166	R:R:N167	10.52	No	Yes	4	3	4
147	R:R:H169	R:R:N167	8.93	Yes	Yes	4	2	4
148	R:R:E174	R:R:Y176	12.35	No	Yes	2	5	6
149	R:R:E174	R:R:Y268	10.1	No	Yes	2	5	5
150	R:R:H175	R:R:Q179	18.54	No	No	0	4	1
151	R:R:R251	R:R:Y176	6.17	Yes	Yes	0	5	6
152	R:R:F265	R:R:Y176	10.32	Yes	Yes	2	3	6
153	R:R:H269	R:R:Y176	7.62	Yes	Yes	2	4	6
154	R:R:I178	R:R:Q182	10.98	No	No	0	4	4
155	R:R:I178	R:R:R183	3.76	No	No	0	4	2
156	R:R:I178	R:R:R251	7.52	No	Yes	0	4	5
157	R:R:Q179	R:R:W181	6.57	No	Yes	0	1	3
158	R:R:Q182	R:R:W181	10.95	No	Yes	0	4	3
159	R:R:N186	R:R:R189	4.82	No	No	0	4	5
160	R:R:L248	R:R:N186	13.73	No	No	0	5	4
161	R:R:N186	R:R:S252	7.45	No	No	0	4	6
162	R:R:V253	R:R:Y187	5.05	No	No	0	4	4
163	R:R:V192	R:R:Y188	3.79	No	No	0	4	3
164	R:R:F190	R:R:F194	4.29	No	No	0	6	8
165	R:R:F190	R:R:L249	10.96	No	No	0	6	5
166	R:R:L191	R:R:L195	4.15	No	No	0	4	4
167	R:R:G193	R:R:P197	4.06	No	Yes	0	5	9
168	R:R:F194	R:R:L242	6.09	No	No	0	8	4
169	R:R:F194	R:R:H245	20.36	No	Yes	0	8	8
170	R:R:F196	R:R:P197	4.33	No	Yes	0	5	9
171	R:R:I198	R:R:L202	5.71	No	No	0	6	3
172	R:R:F237	R:R:I198	5.02	Yes	No	0	9	6
173	R:R:I198	R:R:L238	4.28	No	No	0	6	5
174	R:R:F237	R:R:L201	7.31	Yes	No	1	9	8
175	R:R:V230	R:R:Y205	7.57	No	Yes	0	7	8
176	R:R:V234	R:R:Y205	3.79	No	Yes	0	7	8
177	R:R:L209	R:R:Q227	3.99	No	No	0	5	6
178	R:R:L209	R:R:V230	10.43	No	No	0	5	7
179	R:R:R210	R:R:R214	13.86	No	No	0	3	4
180	R:R:K223	R:R:V212	4.55	No	No	0	7	8
181	R:R:S215	R:R:T218	4.8	No	No	0	5	3
182	R:R:K223	R:R:T218	7.51	No	No	0	7	3
183	R:R:Q219	R:R:S221	5.78	No	No	0	4	3
184	R:R:R222	R:R:S221	5.27	No	No	0	5	3
185	R:R:D224	R:R:R228	10.72	No	No	0	5	6
186	R:R:L285	R:R:T233	7.37	No	Yes	0	8	7
187	R:R:I236	R:R:L285	4.28	No	No	0	6	8
188	R:R:F237	R:R:F241	8.57	Yes	Yes	1	9	9
189	R:R:C240	R:R:F241	4.19	No	Yes	0	8	9
190	R:R:F241	R:R:H245	4.53	Yes	Yes	0	9	8
191	R:R:F241	R:R:N278	9.67	Yes	No	0	9	9
192	R:R:L242	R:R:P243	4.93	No	No	0	4	9
193	R:R:H245	R:R:Y244	6.53	Yes	Yes	0	8	7
194	R:R:L248	R:R:Y244	15.24	No	Yes	0	5	7
195	R:R:Y244	R:R:Y268	5.96	Yes	Yes	0	7	5
196	R:R:L272	R:R:Y244	5.86	No	Yes	0	6	7
197	R:R:L247	R:R:S271	6.01	No	No	0	4	7
198	R:R:E255	R:R:R251	12.79	No	Yes	0	3	5
199	R:R:R251	R:R:Y268	10.29	Yes	Yes	0	5	5
200	R:R:F260	R:R:W254	6.01	Yes	No	0	1	2
201	R:R:E255	R:R:F260	8.16	No	Yes	0	3	1
202	R:R:D259	R:R:S257	8.83	No	No	0	1	5
203	R:R:F260	R:R:V264	10.49	Yes	No	0	1	5
204	R:R:G263	R:R:K262	5.23	No	No	0	2	3
205	R:R:F265	R:R:H269	20.36	Yes	Yes	2	3	4
206	R:R:H269	R:R:Y268	9.8	Yes	Yes	2	4	5
207	R:R:F270	R:R:L274	6.09	No	No	0	6	7
208	R:R:L272	R:R:T275	4.42	No	No	0	6	7
209	R:R:D282	R:R:N278	12.12	Yes	No	0	9	9
210	R:R:D282	R:R:Y286	4.6	Yes	Yes	1	9	9
211	R:R:C287	R:R:F288	4.19	No	No	0	6	7
212	R:R:S290	R:R:T292	6.4	No	No	0	8	6
213	R:R:T233	R:R:Y205	3.75	Yes	Yes	0	7	8
214	R:R:T233	R:R:Y286	3.75	Yes	Yes	0	7	9
215	R:R:A38	R:R:P283	3.74	No	No	0	7	9
216	R:R:S93	R:R:W87	3.71	No	Yes	0	5	9
217	R:R:G110	R:R:V109	3.68	No	Yes	0	5	7
218	R:R:F45	R:R:L41	3.65	Yes	No	0	6	6
219	R:R:F190	R:R:L195	3.65	No	No	0	6	4
220	R:R:I115	R:R:Y59	3.63	Yes	Yes	1	8	7
221	R:R:I208	R:R:Y120	3.63	No	Yes	0	8	8
222	R:R:I208	R:R:Y205	3.63	No	Yes	0	8	8
223	R:R:N86	R:R:R170	3.62	Yes	Yes	0	4	4
224	R:R:P243	R:R:S271	3.56	No	No	0	9	7
225	R:R:G57	R:R:I50	3.53	No	No	0	7	5
226	R:R:P197	R:R:V109	3.53	Yes	Yes	0	9	7
227	R:R:C97	R:R:S73	3.44	Yes	No	0	5	6
228	R:R:F76	R:R:H89	3.39	No	No	0	6	7
229	R:R:C279	R:R:I71	3.27	No	No	0	8	5
230	R:R:A66	R:R:I107	3.25	No	No	0	8	7
231	R:R:V33	R:R:V34	3.21	No	No	0	5	6
232	R:R:V280	R:R:V34	3.21	No	No	0	7	6
233	R:R:V139	R:R:V58	3.21	No	Yes	0	3	6
234	R:R:S290	R:R:T293	3.2	No	No	0	8	8
235	R:R:T30	R:R:V34	3.17	No	No	0	4	6
236	R:R:C40	R:R:L68	3.17	No	No	0	3	7
237	R:R:C61	R:R:L43	3.17	No	No	0	6	6
238	R:R:A24	R:R:L273	3.15	No	Yes	0	5	5
239	R:R:A267	R:R:L247	3.15	No	No	0	5	4
240	R:R:I50	R:R:V58	3.07	No	Yes	0	5	6
241	R:R:I226	R:R:V212	3.07	No	No	0	7	8
242	R:R:A261	R:R:E255	3.02	No	No	0	3	3
243	R:R:L229	R:R:V289	2.98	No	No	0	7	6
244	R:R:L242	R:R:V246	2.98	No	No	0	4	5
245	R:R:L247	R:R:V250	2.98	No	No	0	4	5
246	R:R:G207	R:R:Y120	2.9	No	Yes	0	3	8
247	R:R:I19	R:R:L23	2.85	No	No	0	3	5
248	R:R:I19	R:R:L273	2.85	No	Yes	0	3	5
249	R:R:E291	R:R:T292	2.82	No	No	0	6	6
250	R:R:C40	R:R:F36	2.79	No	No	0	3	6
251	R:R:D91	R:R:L92	2.71	No	No	0	3	2
252	R:R:H159	R:R:M158	2.63	No	No	0	4	4
253	R:R:F277	R:R:V280	2.62	No	No	0	4	7
254	R:R:S252	R:R:Y187	2.54	No	No	0	6	4
255	R:R:F277	R:R:L274	2.44	No	No	0	4	7
256	R:R:D296	R:R:R295	2.38	No	No	0	4	5
257	R:R:L48	R:R:Y47	2.34	No	No	0	4	2
258	R:R:C61	R:R:G46	1.96	No	No	0	6	6
259	R:R:A38	R:R:G35	1.95	No	No	0	7	8
260	R:R:A24	R:R:P25	1.87	No	No	0	5	6
261	R:R:G140	R:R:V139	1.84	No	No	0	2	3
262	R:R:A261	R:R:C13	1.81	No	No	0	3	7
263	R:R:A124	R:R:A211	1.79	No	No	0	7	5
264	R:R:A137	R:R:T134	1.68	No	No	0	1	6
265	R:R:L78	R:R:P25	1.64	No	No	0	7	6
266	R:R:L74	R:R:P75	1.64	No	No	0	7	9
267	R:R:A281	R:R:I236	1.62	No	No	0	6	6
268	R:R:V123	R:R:V212	1.6	No	No	0	8	8
269	R:R:A147	R:R:L150	1.58	No	No	0	4	4
270	R:R:T18	R:R:T22	1.57	No	No	0	3	3
271	R:R:H125	R:R:P126	1.53	No	No	0	6	8
272	R:R:A137	R:R:E55	1.51	No	Yes	0	1	6
273	R:R:G90	R:R:R170	1.5	No	Yes	0	8	4
274	R:R:K136	R:R:T134	1.5	No	No	0	4	6
275	R:R:G207	R:R:R210	1.5	No	No	0	3	3
276	R:R:L285	R:R:S232	1.5	No	No	0	8	6
277	R:R:L135	R:R:V58	1.49	No	Yes	0	3	6
278	R:R:L92	R:R:V96	1.49	No	No	0	2	4
279	R:R:L100	R:R:V96	1.49	No	No	0	5	4
280	R:R:L191	R:R:V192	1.49	No	No	0	4	4
281	R:R:L231	R:R:V230	1.49	No	No	0	4	7
282	R:R:L231	R:R:V235	1.49	No	No	0	4	4
283	R:R:L229	R:R:T233	1.47	No	Yes	0	7	7
284	R:R:D16	R:R:T18	1.45	No	No	0	3	3
285	R:R:H294	R:R:T293	1.37	No	No	0	8	8
286	R:R:D296	R:R:L48	1.36	No	No	0	4	4
287	R:R:N167	R:R:Q168	1.32	Yes	No	0	4	4
288	R:R:R228	R:R:S232	1.32	No	No	0	6	6
289	R:R:D224	R:R:Q225	1.31	No	No	0	5	7
290	R:R:F288	R:R:V284	1.31	No	No	0	7	6
291	R:R:D259	R:R:F260	1.19	No	Yes	0	1	1
292	R:R:Q225	R:R:R222	1.17	No	No	0	7	5
293	R:R:E164	R:R:R170	1.16	No	Yes	0	1	4
294	R:R:H130	R:R:R133	1.13	No	Yes	0	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:H20	10.165	4	2	4
2	R:R:F45	5.71	4	0	6
3	R:R:E55	5.832	5	1	6
4	R:R:V58	3.215	4	0	6
5	R:R:Y59	6.49833	6	1	7
6	R:R:D67	6.698	5	1	9
7	R:R:Y70	6.77	4	0	6
8	R:R:W77	7.702	5	0	6
9	R:R:N86	5.4175	4	0	4
10	R:R:W87	7.636	5	6	9
11	R:R:C97	4.87	4	0	5
12	R:R:Y102	7.9025	4	2	5
13	R:R:E103	12.34	4	3	5
14	R:R:V109	5.0775	4	1	7
15	R:R:F111	9.51	4	5	7
16	R:R:L112	4.7375	4	1	8
17	R:R:I115	5.0425	4	1	8
18	R:R:Y120	5.205	4	0	8
19	R:R:F129	7.76	4	0	6
20	R:R:R133	4.265	4	1	7
21	R:R:W146	5.6	5	5	9
22	R:R:F156	6.682	5	3	4
23	R:R:N167	6.2025	4	4	4
24	R:R:H169	9.91	4	4	2
25	R:R:R170	3.8575	4	0	4
26	R:R:Y176	9.468	5	2	6
27	R:R:W181	10.56	5	3	3
28	R:R:P197	3.9225	4	0	9
29	R:R:Y205	5.21167	6	0	8
30	R:R:T233	4.085	4	0	7
31	R:R:F237	6.464	5	1	9
32	R:R:F241	6.42167	6	1	9
33	R:R:Y244	8.3975	4	0	7
34	R:R:H245	10.5775	4	0	8
35	R:R:R251	9.1925	4	0	5
36	R:R:F260	6.4625	4	0	1
37	R:R:F265	10.0275	4	2	3
38	R:R:Y268	8.024	5	2	5
39	R:R:H269	13.0275	4	2	4
40	R:R:L273	4.535	4	0	5
41	R:R:D282	7.93	5	1	9
42	R:R:Y286	5.526	5	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A261	R:R:E255	10.0278	3.02	No	No	0	3	3
2	R:R:E255	R:R:R251	24.7234	12.79	No	Yes	0	3	5
3	R:R:R251	R:R:Y176	12.8675	6.17	Yes	Yes	0	5	6
4	R:R:D85	R:R:H20	22.215	15.13	No	Yes	0	4	4
5	R:R:D85	R:R:H17	43.0634	21.43	No	No	0	4	4
6	R:R:H17	R:R:H84	41.0223	9.55	No	No	0	4	3
7	R:R:H169	R:R:H84	36.9047	15.53	Yes	No	0	2	3
8	R:R:H20	R:R:H269	26.6166	14.33	Yes	Yes	2	4	4
9	R:R:R251	R:R:Y268	41.9393	10.29	Yes	Yes	0	5	5
10	R:R:H269	R:R:Y268	26.3858	9.8	Yes	Yes	2	4	5
11	R:R:H20	R:R:V81	18.3754	5.54	Yes	No	0	4	5
12	R:R:V81	R:R:Y28	17.9672	3.79	No	No	0	5	8
13	R:R:L273	R:R:Y28	40.9572	4.69	Yes	No	0	5	8
14	R:R:I19	R:R:L273	13.3053	2.85	No	Yes	0	3	5
15	R:R:L273	R:R:V27	17.8844	7.45	Yes	No	0	5	5
16	R:R:F277	R:R:V27	15.6895	3.93	No	No	0	4	5
17	R:R:Y102	R:R:Y268	13.8614	3.97	Yes	Yes	2	5	5
18	R:R:L101	R:R:Y102	24.8891	8.21	No	Yes	0	6	5
19	R:R:L101	R:R:Y70	86.4699	8.21	No	Yes	0	6	6
20	R:R:L74	R:R:Y70	33.0888	5.86	No	Yes	0	7	6
21	R:R:C279	R:R:Y70	98.9292	5.38	No	Yes	0	8	6
22	R:R:C279	R:R:D67	99.4971	6.22	No	Yes	0	8	9
23	R:R:D67	R:R:N39	43.4065	10.77	Yes	No	0	9	9
24	R:R:N39	R:R:T64	36.5911	5.85	No	No	0	9	8
25	R:R:S42	R:R:T64	29.5865	7.99	No	No	0	8	8
26	R:R:C287	R:R:S42	27.8057	6.89	No	No	0	6	8
27	R:R:C287	R:R:F45	22.3925	4.19	No	Yes	0	6	6
28	R:R:Y244	R:R:Y268	61.4565	5.96	Yes	Yes	0	7	5
29	R:R:H245	R:R:Y244	68.4731	6.53	Yes	Yes	0	8	7
30	R:R:F241	R:R:H245	68.9877	4.53	Yes	Yes	0	9	8
31	R:R:F237	R:R:F241	39.3717	8.57	Yes	Yes	1	9	9
32	R:R:F237	R:R:L112	25.5694	4.87	Yes	Yes	1	9	8
33	R:R:L112	R:R:Y286	20.8247	5.86	Yes	Yes	1	8	9
34	R:R:I115	R:R:Y286	49.7604	7.25	Yes	Yes	1	8	9
35	R:R:F241	R:R:N278	28.3618	9.67	Yes	No	0	9	9
36	R:R:D282	R:R:N278	28.7996	12.12	Yes	No	0	9	9
37	R:R:D282	R:R:Y286	100	4.6	Yes	Yes	1	9	9
38	R:R:I115	R:R:Y59	44.4655	3.63	Yes	Yes	1	8	7
39	R:R:E55	R:R:Y59	14.7311	5.61	Yes	Yes	1	6	7
40	R:R:A138	R:R:Y59	15.1926	5.34	No	Yes	1	7	7
41	R:R:A138	R:R:V58	13.3408	5.09	No	Yes	0	7	6
42	R:R:I178	R:R:R251	30.7283	7.52	No	Yes	0	4	5
43	R:R:I178	R:R:Q182	26.8473	10.98	No	No	0	4	4
44	R:R:Q182	R:R:W181	25.1671	10.95	No	Yes	0	4	3
45	R:R:F156	R:R:W181	22.3392	4.01	Yes	Yes	3	4	3
46	R:R:F156	R:R:I99	26.9656	7.54	Yes	No	3	4	5
47	R:R:I99	R:R:S153	25.4156	4.64	No	No	3	5	6
48	R:R:E149	R:R:S153	47.6543	8.62	No	No	0	7	6
49	R:R:E149	R:R:W146	37.5555	5.45	No	Yes	0	7	9
50	R:R:F111	R:R:W146	10.2999	7.02	Yes	Yes	5	7	9
51	R:R:E103	R:R:F156	28.7227	11.66	Yes	Yes	3	5	4
52	R:R:E103	R:R:S153	25.5694	7.19	Yes	No	3	5	6
53	R:R:L101	R:R:W77	91.6405	19.36	No	Yes	0	6	6
54	R:R:C97	R:R:W77	21.5879	3.92	Yes	Yes	0	5	6
55	R:R:C97	R:R:S73	13.4118	3.44	Yes	No	0	5	6
56	R:R:L100	R:R:S73	11.2051	9.01	No	No	0	5	6
57	R:R:D85	R:R:Y80	29.2966	17.24	No	No	0	4	5
58	R:R:W77	R:R:Y80	30.4739	5.79	Yes	No	0	6	5
59	R:R:G98	R:R:W77	57.9483	4.22	No	Yes	0	5	6
60	R:R:H169	R:R:N86	19.961	3.83	Yes	Yes	0	2	4
61	R:R:F156	R:R:F173	50.8194	6.43	Yes	No	0	4	3
62	R:R:R189	R:R:Y106	10.8738	10.29	No	No	0	5	7
63	R:R:L248	R:R:Y244	11.85	15.24	No	Yes	0	5	7
64	R:R:I107	R:R:W146	10.4833	5.87	No	Yes	0	7	9
65	R:R:F241	R:R:V109	12.5362	6.55	Yes	Yes	1	9	7
66	R:R:F237	R:R:L201	19.3575	7.31	Yes	No	1	9	8
67	R:R:P197	R:R:V109	14.2992	3.53	Yes	Yes	0	9	7
68	R:R:R119	R:R:Y286	24.7885	6.17	No	Yes	1	9	9
69	R:R:L201	R:R:S116	20.4816	4.5	No	No	0	8	9
70	R:R:S116	R:R:Y205	18.1151	6.36	No	Yes	0	9	8
71	R:R:I208	R:R:Y120	35.1417	3.63	No	Yes	0	8	8
72	R:R:I208	R:R:Y205	52.6001	3.63	No	Yes	0	8	8
73	R:R:H125	R:R:Y120	19.1682	7.62	No	Yes	0	6	8
74	R:R:F129	R:R:H125	13.749	9.05	Yes	No	0	6	6
75	R:R:I208	R:R:V123	15.8197	4.61	No	No	0	8	8
76	R:R:Q179	R:R:W181	10.1343	6.57	No	Yes	0	1	3
77	R:R:N186	R:R:S252	12.3469	7.45	No	No	0	4	6
78	R:R:F194	R:R:H245	29.5628	20.36	No	Yes	0	8	8
79	R:R:F190	R:R:F194	12.9504	4.29	No	No	0	6	8
80	R:R:F194	R:R:L242	15.0683	6.09	No	No	0	8	4
81	R:R:V230	R:R:Y205	13.5716	7.57	No	Yes	0	7	8
82	R:R:V123	R:R:V212	13.2521	1.6	No	No	0	8	8
83	R:R:T233	R:R:Y286	48.9736	3.75	Yes	Yes	0	7	9
84	R:R:L285	R:R:T233	22.1795	7.37	No	Yes	0	8	7
85	R:R:L285	R:R:S232	15.6777	1.5	No	No	0	8	6
86	R:R:R228	R:R:S232	13.4828	1.32	No	No	0	6	6
87	R:R:D224	R:R:R228	11.2643	10.72	No	No	0	5	6
88	R:R:L242	R:R:P243	10.8206	4.93	No	No	0	4	9
89	R:R:E255	R:R:F260	12.5067	8.16	No	Yes	0	3	1
90	R:R:L74	R:R:Y28	28.6872	7.03	No	No	0	7	8
91	R:R:D282	R:R:D67	99.9704	6.65	Yes	Yes	1	9	9
92	R:R:F173	R:R:G98	56.3983	9.03	No	No	0	3	5
93	R:R:R119	R:R:Y205	27.6164	6.17	No	Yes	0	9	8
94	R:R:T233	R:R:Y205	25.3091	3.75	Yes	Yes	0	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8Z68_nogp

PDB Summary
PDB	8Z68_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.76
Number of Linked Nodes	262
Number of Links	294
Number of Hubs	42
Number of Links mediated by Hubs	151
Number of Communities	6
Number of Nodes involved in Communities	42
Number of Links involved in Communities	57

Path Summary
Number Of Nodes in MetaPath	95
Number Of Links MetaPath	94
Number of Shortest Paths	54030
Length Of Smallest Path	3
Average Path Length	12.6992
Length of Longest Path	25
Minimum Path Strength	1.24
Average Path Strength	7.20924
Maximum Path Strength	19.335
Minimum Path Correlation	0.7
Average Path Correlation	0.920035
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	48.7372
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.553
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q15743
Sequence	>8Z68_nogp_Chain_R C T I D H T I H Q T L A P V V Y V T V L V V G F P A N C L S L Y F G Y L Q I K A R N E L G V Y L C N L T V A D L F Y I C S L P F W L Q Y V L Q H D N W S H G D L S C Q V C G I L L Y E N I Y I S V G F L C C I S V D R Y L A V A H P F R F H Q F R T L K A A V G V S V V I W A K E L L T S I Y F L M H E E V I E D E N Q H R V C F E H Y P I Q A W Q R A I N Y Y R F L V G F L F P I C L L L A S Y Q G I L R A V R R S H G T Q K S R K D Q I Q R L V L S T V V I F L A C F L P Y H V L L L V R S V W E A S C D F A K G V F N A Y H F S L L L T S F N C V A D P V L Y C F V S E T T H R D L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9BHM	A	Orphan	Orphan	GPR68	Homo sapiens	-	-	Gs/β1	2.9	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BHM (No Gprot)	A	Orphan	Orphan	GPR68	Homo sapiens	-	-		2.9	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BI6	A	Orphan	Orphan	GPR68	Homo sapiens	-	-	chim(Gs-CtGq)/β1/γ2	2.9	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BI6 (No Gprot)	A	Orphan	Orphan	GPR68	Homo sapiens	-	-		2.9	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	8Z3O	A	Orphan	Orphan	GPR68	Homo sapiens	-	-	-	3.3	2025-04-23	To be published
	8Z5H	A	Orphan	Orphan	GPR68	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.3	2025-04-23	To be published
	8Z5H (No Gprot)	A	Orphan	Orphan	GPR68	Homo sapiens	-	-		3.3	2025-04-23	To be published
	8Z68	A	Orphan	Orphan	GPR68	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.64	2025-04-23	To be published
	8Z68 (No Gprot)	A	Orphan	Orphan	GPR68	Homo sapiens	-	-		2.64	2025-04-23	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8Z68_nogp.zip

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