psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C13	R:R:I15	3.27	No	No	0	7	2
2	R:R:C13	R:R:C258	7.28	No	No	0	7	5
3	R:R:E166	R:R:T14	5.64	No	No	0	3	3
4	R:R:I15	R:R:Y176	4.84	No	Yes	3	2	6
5	R:R:F265	R:R:I15	8.79	Yes	No	3	3	2
6	R:R:H17	R:R:Q21	8.65	No	No	0	4	4
7	R:R:H17	R:R:H84	5.97	No	No	0	4	3
8	R:R:D85	R:R:H17	21.43	No	No	0	4	4
9	R:R:I19	R:R:T22	3.04	No	No	0	3	3
10	R:R:F265	R:R:I19	3.77	Yes	No	3	3	3
11	R:R:I19	R:R:N266	12.74	No	No	3	3	1
12	R:R:H20	R:R:V81	9.69	No	No	0	4	5
13	R:R:D85	R:R:H20	10.08	No	No	0	4	4
14	R:R:A24	R:R:Y28	5.34	No	Yes	2	5	8
15	R:R:A24	R:R:V81	3.39	No	No	0	5	5
16	R:R:A24	R:R:L273	3.15	No	No	2	5	5
17	R:R:P25	R:R:V81	3.53	No	No	0	6	5
18	R:R:L273	R:R:V27	2.98	No	Yes	2	5	5
19	R:R:F277	R:R:V27	2.62	No	Yes	0	4	5
20	R:R:W77	R:R:Y28	2.89	Yes	Yes	2	6	8
21	R:R:L78	R:R:Y28	4.69	No	Yes	0	7	8
22	R:R:L273	R:R:Y28	3.52	No	Yes	2	5	8
23	R:R:L78	R:R:V29	2.98	No	No	0	7	6
24	R:R:L74	R:R:V31	2.98	No	No	0	7	7
25	R:R:S276	R:R:V31	4.85	No	No	0	7	7
26	R:R:F277	R:R:V31	2.62	No	No	0	4	7
27	R:R:L32	R:R:P75	3.28	No	No	0	6	9
28	R:R:V33	R:R:V34	3.21	No	No	0	5	6
29	R:R:F36	R:R:P37	4.33	No	No	0	6	5
30	R:R:C40	R:R:F36	4.19	No	No	0	3	6
31	R:R:A38	R:R:P283	3.74	No	Yes	0	7	9
32	R:R:N39	R:R:T64	4.39	Yes	No	0	9	8
33	R:R:D67	R:R:N39	6.73	Yes	Yes	0	9	9
34	R:R:L68	R:R:N39	2.75	No	Yes	0	7	9
35	R:R:I71	R:R:N39	2.83	No	Yes	0	5	9
36	R:R:N39	R:R:P283	6.52	Yes	Yes	0	9	9
37	R:R:F288	R:R:L41	3.65	Yes	No	0	7	6
38	R:R:S42	R:R:T64	7.99	No	No	0	8	8
39	R:R:P283	R:R:S42	3.56	Yes	No	0	9	8
40	R:R:C287	R:R:S42	3.44	No	No	0	6	8
41	R:R:C61	R:R:L43	3.17	No	No	0	6	6
42	R:R:L43	R:R:T64	4.42	No	No	0	6	8
43	R:R:F45	R:R:Y44	4.13	Yes	No	0	6	4
44	R:R:L48	R:R:Y44	14.07	No	No	0	4	4
45	R:R:C287	R:R:F45	4.19	No	Yes	0	6	6
46	R:R:F45	R:R:T293	18.16	Yes	No	0	6	8
47	R:R:D296	R:R:F45	3.58	No	Yes	0	4	6
48	R:R:K51	R:R:Y47	8.36	No	No	0	6	2
49	R:R:N54	R:R:Q49	6.6	No	No	0	7	4
50	R:R:G57	R:R:Q49	3.29	No	No	0	7	4
51	R:R:G57	R:R:I50	3.53	No	No	0	7	5
52	R:R:I50	R:R:V58	3.07	No	No	0	5	6
53	R:R:E55	R:R:N54	2.63	Yes	No	0	6	7
54	R:R:L56	R:R:N54	4.12	No	No	0	7	7
55	R:R:D118	R:R:E55	5.2	Yes	Yes	7	8	6
56	R:R:E55	R:R:R133	9.3	Yes	Yes	7	6	7
57	R:R:L56	R:R:L60	4.15	No	No	0	7	7
58	R:R:D118	R:R:L56	4.07	Yes	No	0	8	7
59	R:R:A138	R:R:V58	5.09	No	No	0	7	6
60	R:R:C114	R:R:Y59	5.38	No	Yes	0	6	7
61	R:R:D118	R:R:Y59	4.6	Yes	Yes	0	8	7
62	R:R:A138	R:R:Y59	4	No	Yes	0	7	7
63	R:R:F111	R:R:N62	13.29	Yes	No	4	7	9
64	R:R:N62	R:R:S142	10.43	No	No	4	9	6
65	R:R:N62	R:R:W146	5.65	No	Yes	4	9	9
66	R:R:D67	R:R:L63	2.71	Yes	Yes	1	9	9
67	R:R:L63	R:R:S108	3	Yes	No	1	9	9
68	R:R:L112	R:R:L63	2.77	No	Yes	1	8	9
69	R:R:D282	R:R:L63	5.43	Yes	Yes	1	9	9
70	R:R:F69	R:R:V65	2.62	No	No	0	7	5
71	R:R:A66	R:R:I107	3.25	No	Yes	0	8	7
72	R:R:D67	R:R:S108	4.42	Yes	No	1	9	9
73	R:R:C279	R:R:D67	4.67	No	Yes	0	8	9
74	R:R:D282	R:R:D67	6.65	Yes	Yes	1	9	9
75	R:R:F69	R:R:W146	4.01	No	Yes	0	7	9
76	R:R:L101	R:R:Y70	3.52	No	No	0	6	6
77	R:R:S276	R:R:Y70	5.09	No	No	0	7	6
78	R:R:C279	R:R:I71	4.91	No	No	0	8	5
79	R:R:S73	R:R:W77	6.18	No	Yes	2	6	6
80	R:R:C97	R:R:S73	3.44	Yes	No	2	5	6
81	R:R:L100	R:R:S73	4.5	No	No	0	5	6
82	R:R:F76	R:R:H89	4.53	No	Yes	0	6	7
83	R:R:C97	R:R:F76	5.59	Yes	No	0	5	6
84	R:R:W77	R:R:Y80	3.86	Yes	No	2	6	5
85	R:R:W77	R:R:W87	5.62	Yes	Yes	2	6	9
86	R:R:C97	R:R:W77	5.22	Yes	Yes	2	5	6
87	R:R:L101	R:R:W77	10.25	No	Yes	0	6	6
88	R:R:C172	R:R:W77	2.61	Yes	Yes	2	9	6
89	R:R:L78	R:R:L82	5.54	No	No	0	7	4
90	R:R:Q79	R:R:Q83	8.96	No	No	0	4	4
91	R:R:H89	R:R:Q79	7.42	Yes	No	0	7	4
92	R:R:D85	R:R:Y80	14.94	No	No	0	4	5
93	R:R:W87	R:R:Y80	8.68	Yes	No	2	9	5
94	R:R:Q83	R:R:S88	7.22	No	No	0	4	3
95	R:R:H169	R:R:N86	6.38	No	No	0	2	4
96	R:R:N86	R:R:R170	3.62	No	No	0	4	4
97	R:R:H89	R:R:W87	3.17	Yes	Yes	0	7	9
98	R:R:C94	R:R:W87	6.53	No	Yes	2	9	9
99	R:R:C97	R:R:W87	5.22	Yes	Yes	2	5	9
100	R:R:C172	R:R:W87	3.92	Yes	Yes	2	9	9
101	R:R:H89	R:R:S88	5.58	Yes	No	0	7	3
102	R:R:H89	R:R:S93	2.79	Yes	No	0	7	5
103	R:R:D91	R:R:I163	2.8	No	No	0	3	1
104	R:R:L92	R:R:V96	2.98	No	No	0	2	4
105	R:R:C172	R:R:C94	7.28	Yes	No	2	9	9
106	R:R:L157	R:R:Q95	6.65	No	No	0	4	7
107	R:R:Q95	R:R:V162	4.3	No	No	0	7	5
108	R:R:F173	R:R:G98	7.53	Yes	No	0	3	5
109	R:R:L100	R:R:N104	5.49	No	No	0	5	8
110	R:R:L101	R:R:Y102	5.86	No	Yes	0	6	5
111	R:R:F173	R:R:Y102	9.28	Yes	Yes	0	3	5
112	R:R:E174	R:R:Y102	8.98	Yes	Yes	0	5	5
113	R:R:L272	R:R:Y102	4.69	No	Yes	0	6	5
114	R:R:E103	R:R:Y106	3.37	No	Yes	6	5	7
115	R:R:E103	R:R:F156	7	No	No	0	5	4
116	R:R:E103	R:R:R189	8.14	No	Yes	6	5	5
117	R:R:E149	R:R:N104	5.26	No	No	0	7	8
118	R:R:I105	R:R:Y106	7.25	No	Yes	0	7	7
119	R:R:R189	R:R:Y106	8.23	Yes	Yes	6	5	7
120	R:R:G193	R:R:Y106	4.35	No	Yes	0	5	7
121	R:R:H245	R:R:Y106	7.62	No	Yes	0	8	7
122	R:R:F111	R:R:I107	3.77	Yes	Yes	4	7	7
123	R:R:I107	R:R:I145	2.94	Yes	No	4	7	6
124	R:R:E149	R:R:I107	9.56	No	Yes	0	7	7
125	R:R:P197	R:R:V109	3.53	No	No	0	9	7
126	R:R:F237	R:R:V109	3.93	Yes	No	8	9	7
127	R:R:F241	R:R:V109	2.62	Yes	No	8	9	7
128	R:R:F111	R:R:S142	3.96	Yes	No	4	7	6
129	R:R:F111	R:R:I145	16.33	Yes	No	4	7	6
130	R:R:F111	R:R:W146	3.01	Yes	Yes	4	7	9
131	R:R:D282	R:R:L112	5.43	Yes	No	1	9	8
132	R:R:L112	R:R:Y286	8.21	No	Yes	1	8	9
133	R:R:C113	R:R:P197	3.77	No	No	0	7	9
134	R:R:I115	R:R:R119	3.76	No	No	0	8	9
135	R:R:I115	R:R:Y286	3.63	No	Yes	0	8	9
136	R:R:L201	R:R:S116	3	No	No	0	8	9
137	R:R:S116	R:R:S204	6.52	No	No	1	9	6
138	R:R:S116	R:R:Y205	10.17	No	Yes	1	9	8
139	R:R:D118	R:R:R133	3.57	Yes	Yes	7	8	7
140	R:R:R119	R:R:Y205	5.14	No	Yes	0	9	8
141	R:R:A124	R:R:Y120	4	No	Yes	1	7	8
142	R:R:H125	R:R:Y120	6.53	Yes	Yes	1	6	8
143	R:R:G207	R:R:Y120	2.9	No	Yes	0	3	8
144	R:R:I208	R:R:Y120	3.63	Yes	Yes	1	8	8
145	R:R:F129	R:R:L121	3.65	Yes	No	0	6	5
146	R:R:A122	R:R:R133	2.77	No	Yes	0	8	7
147	R:R:A124	R:R:H125	4.39	No	Yes	1	7	6
148	R:R:H125	R:R:R128	5.64	Yes	No	1	6	4
149	R:R:F129	R:R:H125	6.79	Yes	Yes	1	6	6
150	R:R:F129	R:R:R128	8.55	Yes	No	1	6	4
151	R:R:F129	R:R:F132	3.22	Yes	No	0	6	3
152	R:R:H130	R:R:R133	4.51	No	Yes	0	5	7
153	R:R:F132	R:R:Q131	8.2	No	No	0	3	4
154	R:R:I145	R:R:V141	3.07	No	No	0	6	4
155	R:R:E149	R:R:W146	3.27	No	Yes	0	7	9
156	R:R:K148	R:R:T152	9.01	No	No	0	4	4
157	R:R:F156	R:R:F173	3.22	No	Yes	0	4	3
158	R:R:E161	R:R:H159	14.77	No	No	5	4	4
159	R:R:H159	R:R:W181	6.35	No	Yes	5	4	3
160	R:R:E161	R:R:W181	8.72	No	Yes	5	4	3
161	R:R:F173	R:R:V162	5.24	Yes	No	0	3	5
162	R:R:I163	R:R:R170	6.26	No	No	0	1	4
163	R:R:E166	R:R:N167	5.26	No	No	0	3	4
164	R:R:E174	R:R:V171	2.85	Yes	No	0	5	3
165	R:R:C172	R:R:F173	2.79	Yes	Yes	0	9	3
166	R:R:E174	R:R:Y176	10.1	Yes	Yes	3	5	6
167	R:R:E174	R:R:Y268	4.49	Yes	Yes	3	5	5
168	R:R:E174	R:R:H269	4.92	Yes	Yes	3	5	4
169	R:R:H175	R:R:Q179	16.07	No	No	5	4	1
170	R:R:H175	R:R:Q182	7.42	No	Yes	5	4	4
171	R:R:F265	R:R:Y176	6.19	Yes	Yes	3	3	6
172	R:R:H269	R:R:Y176	4.36	Yes	Yes	3	4	6
173	R:R:I178	R:R:Q182	6.86	No	Yes	0	4	4
174	R:R:I178	R:R:R251	6.26	No	Yes	0	4	5
175	R:R:Q179	R:R:W181	7.67	No	Yes	5	1	3
176	R:R:Q179	R:R:Q182	3.84	No	Yes	5	1	4
177	R:R:Q182	R:R:W181	4.38	Yes	Yes	5	4	3
178	R:R:R183	R:R:S252	3.95	No	No	0	2	6
179	R:R:N186	R:R:R189	4.82	No	Yes	6	4	5
180	R:R:L248	R:R:N186	13.73	No	No	6	5	4
181	R:R:N186	R:R:S252	8.94	No	No	0	4	6
182	R:R:S252	R:R:Y187	6.36	No	No	0	6	4
183	R:R:V253	R:R:Y187	5.05	No	No	0	4	4
184	R:R:V192	R:R:Y188	6.31	No	No	0	4	3
185	R:R:L248	R:R:R189	4.86	No	Yes	6	5	5
186	R:R:F190	R:R:L191	4.87	No	No	0	6	4
187	R:R:F190	R:R:L249	6.09	No	No	0	6	5
188	R:R:F194	R:R:L242	3.65	No	No	0	8	4
189	R:R:F194	R:R:H245	13.58	No	No	0	8	8
190	R:R:F196	R:R:P197	4.33	No	No	0	5	9
191	R:R:F196	R:R:L200	8.53	No	No	0	5	6
192	R:R:I198	R:R:L202	2.85	Yes	No	0	6	3
193	R:R:I198	R:R:L238	2.85	Yes	No	0	6	5
194	R:R:F237	R:R:L201	4.87	Yes	No	0	9	8
195	R:R:S204	R:R:Y205	3.82	No	Yes	1	6	8
196	R:R:V230	R:R:Y205	7.57	No	Yes	0	7	8
197	R:R:T233	R:R:Y205	4.99	No	Yes	1	7	8
198	R:R:V234	R:R:Y205	3.79	No	Yes	0	7	8
199	R:R:L209	R:R:Q227	3.99	No	No	0	5	6
200	R:R:L209	R:R:V230	10.43	No	No	0	5	7
201	R:R:R210	R:R:R213	4.26	No	No	9	3	4
202	R:R:I226	R:R:V212	3.07	No	Yes	0	7	8
203	R:R:S215	R:R:T218	6.4	No	No	0	5	3
204	R:R:K223	R:R:T218	3	No	No	0	7	3
205	R:R:Q219	R:R:S221	4.33	No	No	0	4	3
206	R:R:Q219	R:R:R222	4.67	No	No	0	4	5
207	R:R:D224	R:R:K220	4.15	No	No	0	5	4
208	R:R:L231	R:R:Q227	5.32	No	No	0	4	6
209	R:R:L229	R:R:V289	4.47	No	No	0	7	6
210	R:R:L285	R:R:T233	4.42	No	No	1	8	7
211	R:R:T233	R:R:Y286	3.75	No	Yes	1	7	9
212	R:R:I236	R:R:L285	4.28	No	No	0	6	8
213	R:R:F237	R:R:F241	7.5	Yes	Yes	8	9	9
214	R:R:C240	R:R:N278	4.72	No	No	0	8	9
215	R:R:F241	R:R:T275	2.59	Yes	No	0	9	7
216	R:R:F241	R:R:N278	10.87	Yes	No	0	9	9
217	R:R:L242	R:R:P243	3.28	No	No	0	4	9
218	R:R:L242	R:R:V246	2.98	No	No	0	4	5
219	R:R:H245	R:R:Y244	8.71	No	Yes	0	8	7
220	R:R:L248	R:R:Y244	4.69	No	Yes	0	5	7
221	R:R:L272	R:R:Y244	4.69	No	Yes	0	6	7
222	R:R:T275	R:R:Y244	3.75	No	Yes	0	7	7
223	R:R:A267	R:R:L247	3.15	No	No	0	5	4
224	R:R:L247	R:R:S271	7.51	No	No	0	4	7
225	R:R:E255	R:R:R251	16.28	Yes	Yes	0	3	5
226	R:R:R251	R:R:V264	2.62	Yes	No	0	5	5
227	R:R:R251	R:R:Y268	12.35	Yes	Yes	0	5	5
228	R:R:V253	R:R:W254	8.58	No	No	0	4	2
229	R:R:E255	R:R:F260	4.66	Yes	No	0	3	1
230	R:R:A261	R:R:E255	6.03	No	Yes	0	3	3
231	R:R:D259	R:R:S257	7.36	No	No	0	1	5
232	R:R:F260	R:R:V264	5.24	No	No	0	1	5
233	R:R:F265	R:R:N266	4.83	Yes	No	3	3	1
234	R:R:F265	R:R:H269	11.31	Yes	Yes	3	3	4
235	R:R:H269	R:R:Y268	7.62	Yes	Yes	3	4	5
236	R:R:D282	R:R:N278	9.42	Yes	No	0	9	9
237	R:R:F288	R:R:P283	2.89	Yes	Yes	0	7	9
238	R:R:L285	R:R:Y286	3.52	No	Yes	1	8	9
239	R:R:C287	R:R:F288	2.79	No	Yes	0	6	7
240	R:R:F288	R:R:L297	4.87	Yes	No	0	7	7
241	R:R:S290	R:R:T292	4.8	No	No	0	8	6
242	R:R:E291	R:R:H294	3.69	No	No	0	6	8
243	R:R:D296	R:R:R295	4.76	No	No	0	4	5
244	R:R:H169	R:R:N167	2.55	No	No	0	2	4
245	R:R:F156	R:R:I99	2.51	No	No	0	4	5
246	R:R:F237	R:R:I198	2.51	Yes	Yes	0	9	6
247	R:R:V250	R:R:W254	2.45	No	No	0	5	2
248	R:R:F270	R:R:L23	2.44	No	No	0	6	5
249	R:R:F36	R:R:L68	2.44	No	No	0	6	7
250	R:R:I115	R:R:Y59	2.42	No	Yes	0	8	7
251	R:R:I185	R:R:Y155	2.42	No	No	0	5	8
252	R:R:I208	R:R:Y205	2.42	Yes	Yes	1	8	8
253	R:R:D165	R:R:R170	2.38	No	No	0	2	4
254	R:R:D224	R:R:R228	2.38	No	No	0	5	6
255	R:R:L249	R:R:Y187	2.34	No	No	0	5	4
256	R:R:L247	R:R:Y268	2.34	No	Yes	0	4	5
257	R:R:H159	R:R:Y155	2.18	No	No	0	4	8
258	R:R:R210	R:R:R214	2.13	No	No	9	3	4
259	R:R:R213	R:R:R214	2.13	No	No	9	4	4
260	R:R:G35	R:R:P37	2.03	No	No	0	8	5
261	R:R:C61	R:R:G46	1.96	No	No	0	6	6
262	R:R:C113	R:R:G110	1.96	No	No	0	7	5
263	R:R:G35	R:R:V280	1.84	No	No	0	8	7
264	R:R:G193	R:R:V192	1.84	No	No	0	5	4
265	R:R:C97	R:R:V96	1.71	Yes	No	0	5	4
266	R:R:A211	R:R:V123	1.7	No	No	0	5	8
267	R:R:D91	R:R:G90	1.68	No	No	0	3	8
268	R:R:A137	R:R:T134	1.68	No	No	0	1	6
269	R:R:L74	R:R:P75	1.64	No	No	0	7	9
270	R:R:C199	R:R:I198	1.64	No	Yes	0	3	6
271	R:R:G207	R:R:Q206	1.64	No	No	0	3	4
272	R:R:L274	R:R:P243	1.64	No	No	0	7	9
273	R:R:A281	R:R:I236	1.62	No	No	0	6	6
274	R:R:C258	R:R:K262	1.62	No	No	0	5	3
275	R:R:V26	R:R:V27	1.6	No	Yes	2	5	5
276	R:R:V29	R:R:V33	1.6	No	No	0	6	5
277	R:R:V280	R:R:V34	1.6	No	No	0	7	6
278	R:R:V123	R:R:V212	1.6	No	Yes	1	8	8
279	R:R:V139	R:R:V143	1.6	No	No	0	3	4
280	R:R:T30	R:R:V34	1.59	No	No	0	4	6
281	R:R:G90	R:R:H89	1.59	No	Yes	0	8	7
282	R:R:G217	R:R:H216	1.59	No	No	0	4	3
283	R:R:T18	R:R:T22	1.57	No	No	0	3	3
284	R:R:E255	R:R:P177	1.57	Yes	No	0	3	4
285	R:R:T292	R:R:T293	1.57	No	No	0	6	8
286	R:R:I99	R:R:S153	1.55	No	No	0	5	6
287	R:R:I236	R:R:S232	1.55	No	No	0	6	6
288	R:R:I208	R:R:V123	1.54	Yes	No	1	8	8
289	R:R:I208	R:R:V212	1.54	Yes	Yes	1	8	8
290	R:R:I226	R:R:V230	1.54	No	No	0	7	7
291	R:R:H125	R:R:P126	1.53	Yes	No	0	6	8
292	R:R:K223	R:R:V212	1.52	No	Yes	0	7	8
293	R:R:K136	R:R:T134	1.5	No	No	0	4	6
294	R:R:G207	R:R:R210	1.5	No	No	0	3	3
295	R:R:L23	R:R:V26	1.49	No	No	2	5	5
296	R:R:L23	R:R:V27	1.49	No	Yes	2	5	5
297	R:R:L121	R:R:V117	1.49	No	No	0	5	5
298	R:R:L200	R:R:V117	1.49	No	No	0	6	5
299	R:R:I107	R:R:K148	1.45	Yes	No	0	7	4
300	R:R:F127	R:R:P126	1.44	No	No	0	5	8
301	R:R:K220	R:R:K223	1.44	No	No	0	4	7
302	R:R:L191	R:R:L195	1.38	No	No	0	4	4
303	R:R:E55	R:R:L135	1.33	Yes	No	0	6	3
304	R:R:D165	R:R:Q168	1.31	No	No	0	2	4
305	R:R:F288	R:R:V284	1.31	Yes	No	0	7	6
306	R:R:D165	R:R:E164	1.3	No	No	0	2	1
307	R:R:R222	R:R:T218	1.29	No	No	0	5	3
308	R:R:E160	R:R:Q95	1.27	No	No	0	5	7
309	R:R:E160	R:R:E161	1.27	No	No	0	5	4
310	R:R:L135	R:R:R53	1.21	No	No	0	3	5
311	R:R:D259	R:R:F260	1.19	No	No	0	1	1
312	R:R:L48	R:R:Y47	1.17	No	No	0	4	2
313	R:R:Q225	R:R:R222	1.17	No	No	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:V27	2.1725	4	2	5
2	R:R:Y28	4.11	4	2	8
3	R:R:N39	4.644	5	0	9
4	R:R:F45	7.515	4	0	6
5	R:R:E55	4.615	4	7	6
6	R:R:Y59	4.1	4	0	7
7	R:R:L63	3.4775	4	1	9
8	R:R:D67	5.036	5	1	9
9	R:R:W77	5.23286	7	2	6
10	R:R:W87	5.52333	6	2	9
11	R:R:H89	4.18	6	0	7
12	R:R:C97	4.236	5	2	5
13	R:R:Y102	7.2025	4	0	5
14	R:R:Y106	6.164	5	6	7
15	R:R:I107	4.194	5	4	7
16	R:R:F111	8.072	5	4	7
17	R:R:D118	4.36	4	7	8
18	R:R:Y120	4.265	4	1	8
19	R:R:H125	4.976	5	1	6
20	R:R:F129	5.5525	4	1	6
21	R:R:R133	5.0375	4	7	7
22	R:R:W146	3.985	4	4	9
23	R:R:C172	4.15	4	2	9
24	R:R:F173	5.612	5	0	3
25	R:R:E174	6.268	5	3	5
26	R:R:Y176	6.3725	4	3	6
27	R:R:W181	6.78	4	5	3
28	R:R:Q182	5.625	4	5	4
29	R:R:R189	6.5125	4	6	5
30	R:R:I198	2.4625	4	0	6
31	R:R:Y205	5.41429	7	1	8
32	R:R:I208	2.2825	4	1	8
33	R:R:V212	1.9325	4	1	8
34	R:R:F237	4.7025	4	8	9
35	R:R:F241	5.895	4	8	9
36	R:R:Y244	5.46	4	0	7
37	R:R:R251	9.3775	4	0	5
38	R:R:E255	7.135	4	0	3
39	R:R:F265	6.978	5	3	3
40	R:R:Y268	6.7	4	3	5
41	R:R:H269	7.0525	4	3	4
42	R:R:D282	6.7325	4	1	9
43	R:R:P283	4.1775	4	0	9
44	R:R:Y286	4.7775	4	1	9
45	R:R:F288	3.102	5	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E174	R:R:Y176	12.1541	10.1	Yes	Yes	3	5	6
2	R:R:E174	R:R:Y102	43.1939	8.98	Yes	Yes	0	5	5
3	R:R:L101	R:R:Y102	54.7432	5.86	No	Yes	0	6	5
4	R:R:L101	R:R:W77	48.9354	10.25	No	Yes	0	6	6
5	R:R:W77	R:R:W87	18.5791	5.62	Yes	Yes	2	6	9
6	R:R:H89	R:R:W87	37.034	3.17	Yes	Yes	0	7	9
7	R:R:G90	R:R:H89	25.9983	1.59	No	Yes	0	8	7
8	R:R:D91	R:R:G90	23.8732	1.68	No	No	0	3	8
9	R:R:D91	R:R:I163	21.7399	2.8	No	No	0	3	1
10	R:R:I163	R:R:R170	19.5982	6.26	No	No	0	1	4
11	R:R:N86	R:R:R170	10.9486	3.62	No	No	0	4	4
12	R:R:F173	R:R:Y102	27.4938	9.28	Yes	Yes	0	3	5
13	R:R:C172	R:R:F173	27.8045	2.79	Yes	Yes	0	9	3
14	R:R:C172	R:R:W87	19.4822	3.92	Yes	Yes	2	9	9
15	R:R:W77	R:R:Y28	15.9155	2.89	Yes	Yes	2	6	8
16	R:R:L272	R:R:Y102	90.5551	4.69	No	Yes	0	6	5
17	R:R:L272	R:R:Y244	90.7001	4.69	No	Yes	0	6	7
18	R:R:T275	R:R:Y244	100	3.75	No	Yes	0	7	7
19	R:R:F241	R:R:T275	99.8509	2.59	Yes	No	0	9	7
20	R:R:F241	R:R:N278	64.8923	10.87	Yes	No	0	9	9
21	R:R:D282	R:R:N278	63.9975	9.42	Yes	No	0	9	9
22	R:R:D282	R:R:D67	56.6156	6.65	Yes	Yes	1	9	9
23	R:R:D67	R:R:N39	68.6247	6.73	Yes	Yes	0	9	9
24	R:R:L68	R:R:N39	11.802	2.75	No	Yes	0	7	9
25	R:R:F36	R:R:L68	10.8865	2.44	No	No	0	6	7
26	R:R:N39	R:R:P283	40.9818	6.52	Yes	Yes	0	9	9
27	R:R:N39	R:R:T64	22.7382	4.39	Yes	No	0	9	8
28	R:R:F288	R:R:P283	21.3712	2.89	Yes	Yes	0	7	9
29	R:R:S42	R:R:T64	17.2867	7.99	No	No	0	8	8
30	R:R:P283	R:R:S42	17.1375	3.56	Yes	No	0	9	8
31	R:R:C287	R:R:S42	31.3919	3.44	No	No	0	6	8
32	R:R:C287	R:R:F288	15.8409	2.79	No	Yes	0	6	7
33	R:R:C287	R:R:F45	42.7713	4.19	No	Yes	0	6	6
34	R:R:F45	R:R:Y44	17.4772	4.13	Yes	No	0	6	4
35	R:R:L48	R:R:Y44	13.1193	14.07	No	No	0	4	4
36	R:R:F45	R:R:T293	12.7755	18.16	Yes	No	0	6	8
37	R:R:D282	R:R:L112	37.1417	5.43	Yes	No	1	9	8
38	R:R:L112	R:R:Y286	52.4482	8.21	No	Yes	1	8	9
39	R:R:I115	R:R:Y286	26.6404	3.63	No	Yes	0	8	9
40	R:R:I115	R:R:Y59	29.1176	2.42	No	Yes	0	8	7
41	R:R:D118	R:R:Y59	20.1201	4.6	Yes	Yes	0	8	7
42	R:R:S73	R:R:W77	22.5849	6.18	No	Yes	2	6	6
43	R:R:L100	R:R:S73	24.594	4.5	No	No	0	5	6
44	R:R:L100	R:R:N104	23.2933	5.49	No	No	0	5	8
45	R:R:E149	R:R:N104	21.9843	5.26	No	No	0	7	8
46	R:R:E149	R:R:I107	11.1143	9.56	No	Yes	0	7	7
47	R:R:F173	R:R:V162	11.3173	5.24	Yes	No	0	3	5
48	R:R:Q95	R:R:V162	10.0994	4.3	No	No	0	7	5
49	R:R:F156	R:R:F173	12.4068	3.22	No	Yes	0	4	3
50	R:R:E103	R:R:F156	12.6926	7	No	No	0	5	4
51	R:R:H245	R:R:Y244	13.7697	8.71	No	Yes	0	8	7
52	R:R:L248	R:R:Y244	15.4474	4.69	No	Yes	0	5	7
53	R:R:F241	R:R:V109	11.6736	2.62	Yes	No	8	9	7
54	R:R:P197	R:R:V109	11.8807	3.53	No	No	0	9	7
55	R:R:F237	R:R:F241	32.9536	7.5	Yes	Yes	8	9	9
56	R:R:F237	R:R:L201	30.4888	4.87	Yes	No	0	9	8
57	R:R:L201	R:R:S116	29.7804	3	No	No	0	8	9
58	R:R:S116	R:R:Y205	28.6868	10.17	No	Yes	1	9	8
59	R:R:I208	R:R:Y120	19.4325	3.63	Yes	Yes	1	8	8
60	R:R:I208	R:R:Y205	38.2022	2.42	Yes	Yes	1	8	8
61	R:R:E174	R:R:Y268	23.0613	4.49	Yes	Yes	3	5	5
62	R:R:R251	R:R:Y268	19.9337	12.35	Yes	Yes	0	5	5
63	R:R:L248	R:R:N186	11.1599	13.73	No	No	6	5	4
64	R:R:N186	R:R:S252	14.5775	8.94	No	No	0	4	6
65	R:R:S252	R:R:Y187	11.7274	6.36	No	No	0	6	4
66	R:R:T233	R:R:Y205	20.6711	4.99	No	Yes	1	7	8
67	R:R:T233	R:R:Y286	20.1201	3.75	No	Yes	1	7	9
68	R:R:I208	R:R:V212	16.5907	1.54	Yes	Yes	1	8	8
69	R:R:K223	R:R:V212	15.3273	1.52	No	Yes	0	7	8
70	R:R:D67	R:R:L63	16.0771	2.71	Yes	Yes	1	9	9
71	R:R:L112	R:R:L63	16.367	2.77	No	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9BI6_nogp

PDB Summary
PDB	9BI6_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.59
Number of Linked Nodes	268
Number of Links	313
Number of Hubs	45
Number of Links mediated by Hubs	161
Number of Communities	9
Number of Nodes involved in Communities	66
Number of Links involved in Communities	88

Path Summary
Number Of Nodes in MetaPath	72
Number Of Links MetaPath	71
Number of Shortest Paths	53912
Length Of Smallest Path	3
Average Path Length	13.7252
Length of Longest Path	30
Minimum Path Strength	1.23
Average Path Strength	5.27326
Maximum Path Strength	18.185
Minimum Path Correlation	0.7
Average Path Correlation	0.926347
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	47.8262
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.9642
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • positive regulation of cell communication • regulation of localization • establishment of protein localization • regulation of cellular process • nitrogen compound transport • response to stimulus • positive regulation of establishment of protein localization • cell communication • localization • carbohydrate homeostasis • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • regulation of biological process • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • intracellular glucose homeostasis • protein secretion • establishment of localization • cellular response to oxygen-containing compound • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • chemical homeostasis • response to glucose • response to chemical • glucose homeostasis • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • signaling • homeostatic process • positive regulation of biological process • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • amide transport • signal release • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • biological regulation • regulation of establishment of protein localization • export from cell • cell-cell signaling • response to oxygen-containing compound • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • cellular response to chemical stimulus • cellular homeostasis • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • cellular process • insulin secretion • positive regulation of signaling • developmental process • myeloid leukocyte differentiation • cellular developmental process • hemopoiesis • cell development • mononuclear cell differentiation • myeloid cell differentiation • cell differentiation • anatomical structure development • monocyte differentiation • leukocyte differentiation • multicellular organismal process • regulation of leukocyte differentiation • regulation of cell differentiation • regulation of cell development • positive regulation of developmental process • multicellular organism development • skeletal system development • regulation of immune system process • positive regulation of immune system process • regulation of osteoclast development • system development • positive regulation of cell development • regulation of myeloid leukocyte differentiation • osteoclast development • positive regulation of myeloid leukocyte differentiation • positive regulation of multicellular organismal process • regulation of developmental process • positive regulation of osteoclast differentiation • regulation of osteoclast differentiation • positive regulation of cell differentiation • positive regulation of hemopoiesis • bone cell development • osteoclast differentiation • regulation of multicellular organismal process • bone development • positive regulation of osteoclast development • regulation of multicellular organismal development • regulation of myeloid cell differentiation • animal organ development • immune system process • myeloid cell development • positive regulation of myeloid cell differentiation • regulation of hemopoiesis • positive regulation of leukocyte differentiation • defense response • response to stress • inflammatory response • G protein-coupled receptor signaling pathway • signal transduction • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to abiotic stimulus • cellular response to environmental stimulus • negative regulation of biological process • negative regulation of cellular process • negative regulation of cell differentiation • negative regulation of hemopoiesis • negative regulation of monocyte differentiation • regulation of monocyte differentiation • negative regulation of leukocyte differentiation • negative regulation of developmental process • negative regulation of myeloid cell differentiation • negative regulation of myeloid leukocyte differentiation • negative regulation of cell development • negative regulation of immune system process • negative regulation of multicellular organismal process • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q15743
Sequence	>9BI6_nogp_Chain_R C T I D H T I H Q T L A P V V Y V T V L V V G F P A N C L S L Y F G Y L Q I K A R N E L G V Y L C N L T V A D L F Y I C S L P F W L Q Y V L Q H D N W S H G D L S C Q V C G I L L Y E N I Y I S V G F L C C I S V D R Y L A V A H P F R F H Q F R T L K A A V G V S V V I W A K E L L T S I Y F L M H E E V I E D E N Q H R V C F E H Y P I Q A W Q R A I N Y Y R F L V G F L F P I C L L L A S Y Q G I L R A V R R S H G T Q K S R K D Q I Q R L V L S T V V I F L A C F L P Y H V L L L V R S V W E A S C D F A K G V F N A Y H F S L L L T S F N C V A D P V L Y C F V S E T T H R D L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9BHM	A	Orphan	Orphan	GPR68	Homo sapiens	-	-	Gs/β1	2.9	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BHM (No Gprot)	A	Orphan	Orphan	GPR68	Homo sapiens	-	-		2.9	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BI6	A	Orphan	Orphan	GPR68	Homo sapiens	-	-	chim(Gs-CtGq)/β1/γ2	2.9	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BI6 (No Gprot)	A	Orphan	Orphan	GPR68	Homo sapiens	-	-		2.9	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	8Z3O	A	Orphan	Orphan	GPR68	Homo sapiens	-	-	-	3.3	2025-04-23	To be published
	8Z5H	A	Orphan	Orphan	GPR68	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.3	2025-04-23	To be published
	8Z5H (No Gprot)	A	Orphan	Orphan	GPR68	Homo sapiens	-	-		3.3	2025-04-23	To be published
	8Z68	A	Orphan	Orphan	GPR68	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.64	2025-04-23	To be published
	8Z68 (No Gprot)	A	Orphan	Orphan	GPR68	Homo sapiens	-	-		2.64	2025-04-23	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9BI6_nogp.zip

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