psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C13	R:R:I15	3.27	No	No	0	7	2
2	R:R:C13	R:R:C258	7.28	No	No	0	7	5
3	R:R:E166	R:R:T14	5.64	No	No	0	3	3
4	R:R:I15	R:R:Y176	4.84	No	Yes	3	2	6
5	R:R:F265	R:R:I15	8.79	Yes	No	3	3	2
6	R:R:H17	R:R:Q21	8.65	No	No	0	4	4
7	R:R:H17	R:R:H84	5.97	No	No	0	4	3
8	R:R:D85	R:R:H17	21.43	No	No	0	4	4
9	R:R:I19	R:R:T22	3.04	No	No	0	3	3
10	R:R:F265	R:R:I19	3.77	Yes	No	3	3	3
11	R:R:I19	R:R:N266	12.74	No	No	3	3	1
12	R:R:H20	R:R:V81	9.69	No	No	0	4	5
13	R:R:D85	R:R:H20	10.08	No	No	0	4	4
14	R:R:A24	R:R:Y28	5.34	No	Yes	2	5	8
15	R:R:A24	R:R:V81	3.39	No	No	0	5	5
16	R:R:A24	R:R:L273	3.15	No	No	2	5	5
17	R:R:P25	R:R:V81	3.53	No	No	0	6	5
18	R:R:L273	R:R:V27	2.98	No	Yes	2	5	5
19	R:R:F277	R:R:V27	2.62	No	Yes	0	4	5
20	R:R:W77	R:R:Y28	2.89	Yes	Yes	2	6	8
21	R:R:L78	R:R:Y28	4.69	No	Yes	0	7	8
22	R:R:L273	R:R:Y28	3.52	No	Yes	2	5	8
23	R:R:L78	R:R:V29	2.98	No	No	0	7	6
24	R:R:L74	R:R:V31	2.98	No	No	0	7	7
25	R:R:S276	R:R:V31	4.85	No	No	0	7	7
26	R:R:F277	R:R:V31	2.62	No	No	0	4	7
27	R:R:L32	R:R:P75	3.28	No	No	0	6	9
28	R:R:V33	R:R:V34	3.21	No	No	0	5	6
29	R:R:F36	R:R:P37	4.33	No	No	0	6	5
30	R:R:C40	R:R:F36	4.19	No	No	0	3	6
31	R:R:A38	R:R:P283	3.74	No	Yes	0	7	9
32	R:R:N39	R:R:T64	4.39	Yes	No	0	9	8
33	R:R:D67	R:R:N39	6.73	Yes	Yes	0	9	9
34	R:R:L68	R:R:N39	2.75	No	Yes	0	7	9
35	R:R:I71	R:R:N39	2.83	No	Yes	0	5	9
36	R:R:N39	R:R:P283	6.52	Yes	Yes	0	9	9
37	R:R:F288	R:R:L41	3.65	Yes	No	0	7	6
38	R:R:S42	R:R:T64	7.99	No	No	0	8	8
39	R:R:P283	R:R:S42	3.56	Yes	No	0	9	8
40	R:R:C287	R:R:S42	3.44	No	No	0	6	8
41	R:R:C61	R:R:L43	3.17	No	No	0	6	6
42	R:R:L43	R:R:T64	4.42	No	No	0	6	8
43	R:R:F45	R:R:Y44	4.13	Yes	No	0	6	4
44	R:R:L48	R:R:Y44	14.07	No	No	0	4	4
45	R:R:C287	R:R:F45	4.19	No	Yes	0	6	6
46	R:R:F45	R:R:T293	18.16	Yes	No	0	6	8
47	R:R:D296	R:R:F45	3.58	No	Yes	0	4	6
48	R:R:K51	R:R:Y47	8.36	No	No	0	6	2
49	R:R:N54	R:R:Q49	6.6	No	No	0	7	4
50	R:R:G57	R:R:Q49	3.29	No	No	0	7	4
51	R:R:G57	R:R:I50	3.53	No	No	0	7	5
52	R:R:I50	R:R:V58	3.07	No	No	0	5	6
53	R:R:E55	R:R:N54	2.63	Yes	No	0	6	7
54	R:R:L56	R:R:N54	4.12	No	No	0	7	7
55	R:R:D118	R:R:E55	5.2	Yes	Yes	7	8	6
56	R:R:E55	R:R:R133	9.3	Yes	Yes	7	6	7
57	R:R:L56	R:R:L60	4.15	No	No	0	7	7
58	R:R:D118	R:R:L56	4.07	Yes	No	0	8	7
59	R:R:A138	R:R:V58	5.09	No	No	0	7	6
60	R:R:C114	R:R:Y59	5.38	No	Yes	0	6	7
61	R:R:D118	R:R:Y59	4.6	Yes	Yes	0	8	7
62	R:R:A138	R:R:Y59	4	No	Yes	0	7	7
63	R:R:F111	R:R:N62	13.29	Yes	No	4	7	9
64	R:R:N62	R:R:S142	10.43	No	No	4	9	6
65	R:R:N62	R:R:W146	5.65	No	Yes	4	9	9
66	R:R:D67	R:R:L63	2.71	Yes	Yes	1	9	9
67	R:R:L63	R:R:S108	3	Yes	No	1	9	9
68	R:R:L112	R:R:L63	2.77	No	Yes	1	8	9
69	R:R:D282	R:R:L63	5.43	Yes	Yes	1	9	9
70	R:R:F69	R:R:V65	2.62	No	No	0	7	5
71	R:R:A66	R:R:I107	3.25	No	Yes	0	8	7
72	R:R:D67	R:R:S108	4.42	Yes	No	1	9	9
73	R:R:C279	R:R:D67	4.67	No	Yes	0	8	9
74	R:R:D282	R:R:D67	6.65	Yes	Yes	1	9	9
75	R:R:F69	R:R:W146	4.01	No	Yes	0	7	9
76	R:R:L101	R:R:Y70	3.52	No	No	0	6	6
77	R:R:S276	R:R:Y70	5.09	No	No	0	7	6
78	R:R:C279	R:R:I71	4.91	No	No	0	8	5
79	R:R:S73	R:R:W77	6.18	No	Yes	2	6	6
80	R:R:C97	R:R:S73	3.44	Yes	No	2	5	6
81	R:R:L100	R:R:S73	4.5	No	No	0	5	6
82	R:R:F76	R:R:H89	4.53	No	Yes	0	6	7
83	R:R:C97	R:R:F76	5.59	Yes	No	0	5	6
84	R:R:W77	R:R:Y80	3.86	Yes	No	2	6	5
85	R:R:W77	R:R:W87	5.62	Yes	Yes	2	6	9
86	R:R:C97	R:R:W77	5.22	Yes	Yes	2	5	6
87	R:R:L101	R:R:W77	10.25	No	Yes	0	6	6
88	R:R:C172	R:R:W77	2.61	Yes	Yes	2	9	6
89	R:R:L78	R:R:L82	5.54	No	No	0	7	4
90	R:R:Q79	R:R:Q83	8.96	No	No	0	4	4
91	R:R:H89	R:R:Q79	7.42	Yes	No	0	7	4
92	R:R:D85	R:R:Y80	14.94	No	No	0	4	5
93	R:R:W87	R:R:Y80	8.68	Yes	No	2	9	5
94	R:R:Q83	R:R:S88	7.22	No	No	0	4	3
95	R:R:H169	R:R:N86	6.38	No	No	0	2	4
96	R:R:N86	R:R:R170	3.62	No	No	0	4	4
97	R:R:H89	R:R:W87	3.17	Yes	Yes	0	7	9
98	R:R:C94	R:R:W87	6.53	No	Yes	2	9	9
99	R:R:C97	R:R:W87	5.22	Yes	Yes	2	5	9
100	R:R:C172	R:R:W87	3.92	Yes	Yes	2	9	9
101	R:R:H89	R:R:S88	5.58	Yes	No	0	7	3
102	R:R:H89	R:R:S93	2.79	Yes	No	0	7	5
103	R:R:D91	R:R:I163	2.8	No	No	0	3	1
104	R:R:L92	R:R:V96	2.98	No	No	0	2	4
105	R:R:C172	R:R:C94	7.28	Yes	No	2	9	9
106	R:R:L157	R:R:Q95	6.65	No	No	0	4	7
107	R:R:Q95	R:R:V162	4.3	No	No	0	7	5
108	R:R:F173	R:R:G98	7.53	Yes	No	0	3	5
109	R:R:L100	R:R:N104	5.49	No	No	0	5	8
110	R:R:L101	R:R:Y102	5.86	No	Yes	0	6	5
111	R:R:F173	R:R:Y102	9.28	Yes	Yes	0	3	5
112	R:R:E174	R:R:Y102	8.98	Yes	Yes	0	5	5
113	R:R:L272	R:R:Y102	4.69	No	Yes	0	6	5
114	R:R:E103	R:R:Y106	3.37	No	Yes	6	5	7
115	R:R:E103	R:R:F156	7	No	No	0	5	4
116	R:R:E103	R:R:R189	8.14	No	Yes	6	5	5
117	R:R:E149	R:R:N104	5.26	No	No	0	7	8
118	R:R:I105	R:R:Y106	7.25	No	Yes	0	7	7
119	R:R:R189	R:R:Y106	8.23	Yes	Yes	6	5	7
120	R:R:G193	R:R:Y106	4.35	No	Yes	0	5	7
121	R:R:H245	R:R:Y106	7.62	No	Yes	0	8	7
122	R:R:F111	R:R:I107	3.77	Yes	Yes	4	7	7
123	R:R:I107	R:R:I145	2.94	Yes	No	4	7	6
124	R:R:E149	R:R:I107	9.56	No	Yes	0	7	7
125	R:R:P197	R:R:V109	3.53	No	No	0	9	7
126	R:R:F237	R:R:V109	3.93	Yes	No	8	9	7
127	R:R:F241	R:R:V109	2.62	Yes	No	8	9	7
128	R:R:F111	R:R:S142	3.96	Yes	No	4	7	6
129	R:R:F111	R:R:I145	16.33	Yes	No	4	7	6
130	R:R:F111	R:R:W146	3.01	Yes	Yes	4	7	9
131	R:R:D282	R:R:L112	5.43	Yes	No	1	9	8
132	R:R:L112	R:R:Y286	8.21	No	Yes	1	8	9
133	R:R:C113	R:R:P197	3.77	No	No	0	7	9
134	R:R:I115	R:R:R119	3.76	No	No	0	8	9
135	R:R:I115	R:R:Y286	3.63	No	Yes	0	8	9
136	R:R:L201	R:R:S116	3	No	No	0	8	9
137	R:R:S116	R:R:S204	6.52	No	No	1	9	6
138	R:R:S116	R:R:Y205	10.17	No	Yes	1	9	8
139	R:R:D118	R:R:R133	3.57	Yes	Yes	7	8	7
140	R:R:R119	R:R:Y205	5.14	No	Yes	0	9	8
141	R:R:A124	R:R:Y120	4	No	Yes	1	7	8
142	R:R:H125	R:R:Y120	6.53	Yes	Yes	1	6	8
143	R:R:G207	R:R:Y120	2.9	No	Yes	0	3	8
144	R:R:I208	R:R:Y120	3.63	Yes	Yes	1	8	8
145	R:R:F129	R:R:L121	3.65	Yes	No	0	6	5
146	R:R:A122	R:R:R133	2.77	No	Yes	0	8	7
147	R:R:A124	R:R:H125	4.39	No	Yes	1	7	6
148	R:R:H125	R:R:R128	5.64	Yes	No	1	6	4
149	R:R:F129	R:R:H125	6.79	Yes	Yes	1	6	6
150	R:R:F129	R:R:R128	8.55	Yes	No	1	6	4
151	R:R:F129	R:R:F132	3.22	Yes	No	0	6	3
152	R:R:H130	R:R:R133	4.51	No	Yes	0	5	7
153	R:R:F132	R:R:Q131	8.2	No	No	0	3	4
154	R:R:I145	R:R:V141	3.07	No	No	0	6	4
155	R:R:E149	R:R:W146	3.27	No	Yes	0	7	9
156	R:R:K148	R:R:T152	9.01	No	No	0	4	4
157	R:R:F156	R:R:F173	3.22	No	Yes	0	4	3
158	R:R:E161	R:R:H159	14.77	No	No	5	4	4
159	R:R:H159	R:R:W181	6.35	No	Yes	5	4	3
160	R:R:E161	R:R:W181	8.72	No	Yes	5	4	3
161	R:R:F173	R:R:V162	5.24	Yes	No	0	3	5
162	R:R:I163	R:R:R170	6.26	No	No	0	1	4
163	R:R:E166	R:R:N167	5.26	No	No	0	3	4
164	R:R:E174	R:R:V171	2.85	Yes	No	0	5	3
165	R:R:C172	R:R:F173	2.79	Yes	Yes	0	9	3
166	R:R:E174	R:R:Y176	10.1	Yes	Yes	3	5	6
167	R:R:E174	R:R:Y268	4.49	Yes	Yes	3	5	5
168	R:R:E174	R:R:H269	4.92	Yes	Yes	3	5	4
169	R:R:H175	R:R:Q179	16.07	No	No	5	4	1
170	R:R:H175	R:R:Q182	7.42	No	Yes	5	4	4
171	R:R:F265	R:R:Y176	6.19	Yes	Yes	3	3	6
172	R:R:H269	R:R:Y176	4.36	Yes	Yes	3	4	6
173	R:R:I178	R:R:Q182	6.86	No	Yes	0	4	4
174	R:R:I178	R:R:R251	6.26	No	Yes	0	4	5
175	R:R:Q179	R:R:W181	7.67	No	Yes	5	1	3
176	R:R:Q179	R:R:Q182	3.84	No	Yes	5	1	4
177	R:R:Q182	R:R:W181	4.38	Yes	Yes	5	4	3
178	R:R:R183	R:R:S252	3.95	No	No	0	2	6
179	R:R:N186	R:R:R189	4.82	No	Yes	6	4	5
180	R:R:L248	R:R:N186	13.73	No	No	6	5	4
181	R:R:N186	R:R:S252	8.94	No	No	0	4	6
182	R:R:S252	R:R:Y187	6.36	No	No	0	6	4
183	R:R:V253	R:R:Y187	5.05	No	No	0	4	4
184	R:R:V192	R:R:Y188	6.31	No	No	0	4	3
185	R:R:L248	R:R:R189	4.86	No	Yes	6	5	5
186	R:R:F190	R:R:L191	4.87	No	No	0	6	4
187	R:R:F190	R:R:L249	6.09	No	No	0	6	5
188	R:R:F194	R:R:L242	3.65	No	No	0	8	4
189	R:R:F194	R:R:H245	13.58	No	No	0	8	8
190	R:R:F196	R:R:P197	4.33	No	No	0	5	9
191	R:R:F196	R:R:L200	8.53	No	No	0	5	6
192	R:R:I198	R:R:L202	2.85	Yes	No	0	6	3
193	R:R:I198	R:R:L238	2.85	Yes	No	0	6	5
194	R:R:F237	R:R:L201	4.87	Yes	No	0	9	8
195	R:R:S204	R:R:Y205	3.82	No	Yes	1	6	8
196	R:R:V230	R:R:Y205	7.57	No	Yes	0	7	8
197	R:R:T233	R:R:Y205	4.99	No	Yes	1	7	8
198	R:R:V234	R:R:Y205	3.79	No	Yes	0	7	8
199	R:R:L209	R:R:Q227	3.99	No	No	0	5	6
200	R:R:L209	R:R:V230	10.43	No	No	0	5	7
201	R:R:R210	R:R:R213	4.26	No	No	9	3	4
202	R:R:I226	R:R:V212	3.07	No	Yes	0	7	8
203	R:R:S215	R:R:T218	6.4	No	No	0	5	3
204	R:R:K223	R:R:T218	3	No	No	0	7	3
205	R:R:Q219	R:R:S221	4.33	No	No	0	4	3
206	R:R:Q219	R:R:R222	4.67	No	No	0	4	5
207	R:R:D224	R:R:K220	4.15	No	No	0	5	4
208	R:R:L231	R:R:Q227	5.32	No	No	0	4	6
209	R:R:L229	R:R:V289	4.47	No	No	0	7	6
210	R:R:L285	R:R:T233	4.42	No	No	1	8	7
211	R:R:T233	R:R:Y286	3.75	No	Yes	1	7	9
212	R:R:I236	R:R:L285	4.28	No	No	0	6	8
213	R:R:F237	R:R:F241	7.5	Yes	Yes	8	9	9
214	R:R:C240	R:R:N278	4.72	No	No	0	8	9
215	R:R:F241	R:R:T275	2.59	Yes	No	0	9	7
216	R:R:F241	R:R:N278	10.87	Yes	No	0	9	9
217	R:R:L242	R:R:P243	3.28	No	No	0	4	9
218	R:R:L242	R:R:V246	2.98	No	No	0	4	5
219	R:R:H245	R:R:Y244	8.71	No	Yes	0	8	7
220	R:R:L248	R:R:Y244	4.69	No	Yes	0	5	7
221	R:R:L272	R:R:Y244	4.69	No	Yes	0	6	7
222	R:R:T275	R:R:Y244	3.75	No	Yes	0	7	7
223	R:R:A267	R:R:L247	3.15	No	No	0	5	4
224	R:R:L247	R:R:S271	7.51	No	No	0	4	7
225	R:R:E255	R:R:R251	16.28	Yes	Yes	0	3	5
226	R:R:R251	R:R:V264	2.62	Yes	No	0	5	5
227	R:R:R251	R:R:Y268	12.35	Yes	Yes	0	5	5
228	R:R:V253	R:R:W254	8.58	No	No	0	4	2
229	R:R:E255	R:R:F260	4.66	Yes	No	0	3	1
230	R:R:A261	R:R:E255	6.03	No	Yes	0	3	3
231	R:R:D259	R:R:S257	7.36	No	No	0	1	5
232	R:R:F260	R:R:V264	5.24	No	No	0	1	5
233	R:R:F265	R:R:N266	4.83	Yes	No	3	3	1
234	R:R:F265	R:R:H269	11.31	Yes	Yes	3	3	4
235	R:R:H269	R:R:Y268	7.62	Yes	Yes	3	4	5
236	R:R:D282	R:R:N278	9.42	Yes	No	0	9	9
237	R:R:F288	R:R:P283	2.89	Yes	Yes	0	7	9
238	R:R:L285	R:R:Y286	3.52	No	Yes	1	8	9
239	R:R:C287	R:R:F288	2.79	No	Yes	0	6	7
240	R:R:F288	R:R:L297	4.87	Yes	No	0	7	7
241	R:R:S290	R:R:T292	4.8	No	No	0	8	6
242	R:R:E291	R:R:H294	3.69	No	No	0	6	8
243	R:R:D296	R:R:R295	4.76	No	No	0	4	5
244	R:R:H169	R:R:N167	2.55	No	No	0	2	4
245	R:R:F156	R:R:I99	2.51	No	No	0	4	5
246	R:R:F237	R:R:I198	2.51	Yes	Yes	0	9	6
247	R:R:V250	R:R:W254	2.45	No	No	0	5	2
248	R:R:F270	R:R:L23	2.44	No	No	0	6	5
249	R:R:F36	R:R:L68	2.44	No	No	0	6	7
250	R:R:I115	R:R:Y59	2.42	No	Yes	0	8	7
251	R:R:I185	R:R:Y155	2.42	No	No	0	5	8
252	R:R:I208	R:R:Y205	2.42	Yes	Yes	1	8	8
253	R:R:D165	R:R:R170	2.38	No	No	0	2	4
254	R:R:D224	R:R:R228	2.38	No	No	0	5	6
255	R:R:L249	R:R:Y187	2.34	No	No	0	5	4
256	R:R:L247	R:R:Y268	2.34	No	Yes	0	4	5
257	R:R:H159	R:R:Y155	2.18	No	No	0	4	8
258	R:R:R210	R:R:R214	2.13	No	No	9	3	4
259	R:R:R213	R:R:R214	2.13	No	No	9	4	4
260	R:R:G35	R:R:P37	2.03	No	No	0	8	5
261	R:R:C61	R:R:G46	1.96	No	No	0	6	6
262	R:R:C113	R:R:G110	1.96	No	No	0	7	5
263	R:R:G35	R:R:V280	1.84	No	No	0	8	7
264	R:R:G193	R:R:V192	1.84	No	No	0	5	4
265	R:R:C97	R:R:V96	1.71	Yes	No	0	5	4
266	R:R:A211	R:R:V123	1.7	No	No	0	5	8
267	R:R:D91	R:R:G90	1.68	No	No	0	3	8
268	R:R:A137	R:R:T134	1.68	No	No	0	1	6
269	R:R:L74	R:R:P75	1.64	No	No	0	7	9
270	R:R:C199	R:R:I198	1.64	No	Yes	0	3	6
271	R:R:G207	R:R:Q206	1.64	No	No	0	3	4
272	R:R:L274	R:R:P243	1.64	No	No	0	7	9
273	R:R:A281	R:R:I236	1.62	No	No	0	6	6
274	R:R:C258	R:R:K262	1.62	No	No	0	5	3
275	R:R:V26	R:R:V27	1.6	No	Yes	2	5	5
276	R:R:V29	R:R:V33	1.6	No	No	0	6	5
277	R:R:V280	R:R:V34	1.6	No	No	0	7	6
278	R:R:V123	R:R:V212	1.6	No	Yes	1	8	8
279	R:R:V139	R:R:V143	1.6	No	No	0	3	4
280	R:R:T30	R:R:V34	1.59	No	No	0	4	6
281	R:R:G90	R:R:H89	1.59	No	Yes	0	8	7
282	R:R:G217	R:R:H216	1.59	No	No	0	4	3
283	R:R:T18	R:R:T22	1.57	No	No	0	3	3
284	R:R:E255	R:R:P177	1.57	Yes	No	0	3	4
285	R:R:T292	R:R:T293	1.57	No	No	0	6	8
286	R:R:I99	R:R:S153	1.55	No	No	0	5	6
287	R:R:I236	R:R:S232	1.55	No	No	0	6	6
288	R:R:I208	R:R:V123	1.54	Yes	No	1	8	8
289	R:R:I208	R:R:V212	1.54	Yes	Yes	1	8	8
290	R:R:I226	R:R:V230	1.54	No	No	0	7	7
291	R:R:H125	R:R:P126	1.53	Yes	No	0	6	8
292	R:R:K223	R:R:V212	1.52	No	Yes	0	7	8
293	R:R:K136	R:R:T134	1.5	No	No	0	4	6
294	R:R:G207	R:R:R210	1.5	No	No	0	3	3
295	R:R:L23	R:R:V26	1.49	No	No	2	5	5
296	R:R:L23	R:R:V27	1.49	No	Yes	2	5	5
297	R:R:L121	R:R:V117	1.49	No	No	0	5	5
298	R:R:L200	R:R:V117	1.49	No	No	0	6	5
299	R:R:I107	R:R:K148	1.45	Yes	No	0	7	4
300	R:R:F127	R:R:P126	1.44	No	No	0	5	8
301	R:R:K220	R:R:K223	1.44	No	No	0	4	7
302	R:R:L191	R:R:L195	1.38	No	No	0	4	4
303	R:R:E55	R:R:L135	1.33	Yes	No	0	6	3
304	R:R:D165	R:R:Q168	1.31	No	No	0	2	4
305	R:R:F288	R:R:V284	1.31	Yes	No	0	7	6
306	R:R:D165	R:R:E164	1.3	No	No	0	2	1
307	R:R:R222	R:R:T218	1.29	No	No	0	5	3
308	R:R:E160	R:R:Q95	1.27	No	No	0	5	7
309	R:R:E160	R:R:E161	1.27	No	No	0	5	4
310	R:R:L135	R:R:R53	1.21	No	No	0	3	5
311	R:R:D259	R:R:F260	1.19	No	No	0	1	1
312	R:R:L48	R:R:Y47	1.17	No	No	0	4	2
313	R:R:Q225	R:R:R222	1.17	No	No	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:V27	2.1725	4	2	5
2	R:R:Y28	4.11	4	2	8
3	R:R:N39	4.644	5	0	9
4	R:R:F45	7.515	4	0	6
5	R:R:E55	4.615	4	7	6
6	R:R:Y59	4.1	4	0	7
7	R:R:L63	3.4775	4	1	9
8	R:R:D67	5.036	5	1	9
9	R:R:W77	5.23286	7	2	6
10	R:R:W87	5.52333	6	2	9
11	R:R:H89	4.18	6	0	7
12	R:R:C97	4.236	5	2	5
13	R:R:Y102	7.2025	4	0	5
14	R:R:Y106	6.164	5	6	7
15	R:R:I107	4.194	5	4	7
16	R:R:F111	8.072	5	4	7
17	R:R:D118	4.36	4	7	8
18	R:R:Y120	4.265	4	1	8
19	R:R:H125	4.976	5	1	6
20	R:R:F129	5.5525	4	1	6
21	R:R:R133	5.0375	4	7	7
22	R:R:W146	3.985	4	4	9
23	R:R:C172	4.15	4	2	9
24	R:R:F173	5.612	5	0	3
25	R:R:E174	6.268	5	3	5
26	R:R:Y176	6.3725	4	3	6
27	R:R:W181	6.78	4	5	3
28	R:R:Q182	5.625	4	5	4
29	R:R:R189	6.5125	4	6	5
30	R:R:I198	2.4625	4	0	6
31	R:R:Y205	5.41429	7	1	8
32	R:R:I208	2.2825	4	1	8
33	R:R:V212	1.9325	4	1	8
34	R:R:F237	4.7025	4	8	9
35	R:R:F241	5.895	4	8	9
36	R:R:Y244	5.46	4	0	7
37	R:R:R251	9.3775	4	0	5
38	R:R:E255	7.135	4	0	3
39	R:R:F265	6.978	5	3	3
40	R:R:Y268	6.7	4	3	5
41	R:R:H269	7.0525	4	3	4
42	R:R:D282	6.7325	4	1	9
43	R:R:P283	4.1775	4	0	9
44	R:R:Y286	4.7775	4	1	9
45	R:R:F288	3.102	5	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E174	R:R:Y176	12.1541	10.1	Yes	Yes	3	5	6
2	R:R:E174	R:R:Y102	43.1939	8.98	Yes	Yes	0	5	5
3	R:R:L101	R:R:Y102	54.7432	5.86	No	Yes	0	6	5
4	R:R:L101	R:R:W77	48.9354	10.25	No	Yes	0	6	6
5	R:R:W77	R:R:W87	18.5791	5.62	Yes	Yes	2	6	9
6	R:R:H89	R:R:W87	37.034	3.17	Yes	Yes	0	7	9
7	R:R:G90	R:R:H89	25.9983	1.59	No	Yes	0	8	7
8	R:R:D91	R:R:G90	23.8732	1.68	No	No	0	3	8
9	R:R:D91	R:R:I163	21.7399	2.8	No	No	0	3	1
10	R:R:I163	R:R:R170	19.5982	6.26	No	No	0	1	4
11	R:R:N86	R:R:R170	10.9486	3.62	No	No	0	4	4
12	R:R:F173	R:R:Y102	27.4938	9.28	Yes	Yes	0	3	5
13	R:R:C172	R:R:F173	27.8045	2.79	Yes	Yes	0	9	3
14	R:R:C172	R:R:W87	19.4822	3.92	Yes	Yes	2	9	9
15	R:R:W77	R:R:Y28	15.9155	2.89	Yes	Yes	2	6	8
16	R:R:L272	R:R:Y102	90.5551	4.69	No	Yes	0	6	5
17	R:R:L272	R:R:Y244	90.7001	4.69	No	Yes	0	6	7
18	R:R:T275	R:R:Y244	100	3.75	No	Yes	0	7	7
19	R:R:F241	R:R:T275	99.8509	2.59	Yes	No	0	9	7
20	R:R:F241	R:R:N278	64.8923	10.87	Yes	No	0	9	9
21	R:R:D282	R:R:N278	63.9975	9.42	Yes	No	0	9	9
22	R:R:D282	R:R:D67	56.6156	6.65	Yes	Yes	1	9	9
23	R:R:D67	R:R:N39	68.6247	6.73	Yes	Yes	0	9	9
24	R:R:L68	R:R:N39	11.802	2.75	No	Yes	0	7	9
25	R:R:F36	R:R:L68	10.8865	2.44	No	No	0	6	7
26	R:R:N39	R:R:P283	40.9818	6.52	Yes	Yes	0	9	9
27	R:R:N39	R:R:T64	22.7382	4.39	Yes	No	0	9	8
28	R:R:F288	R:R:P283	21.3712	2.89	Yes	Yes	0	7	9
29	R:R:S42	R:R:T64	17.2867	7.99	No	No	0	8	8
30	R:R:P283	R:R:S42	17.1375	3.56	Yes	No	0	9	8
31	R:R:C287	R:R:S42	31.3919	3.44	No	No	0	6	8
32	R:R:C287	R:R:F288	15.8409	2.79	No	Yes	0	6	7
33	R:R:C287	R:R:F45	42.7713	4.19	No	Yes	0	6	6
34	R:R:F45	R:R:Y44	17.4772	4.13	Yes	No	0	6	4
35	R:R:L48	R:R:Y44	13.1193	14.07	No	No	0	4	4
36	R:R:F45	R:R:T293	12.7755	18.16	Yes	No	0	6	8
37	R:R:D282	R:R:L112	37.1417	5.43	Yes	No	1	9	8
38	R:R:L112	R:R:Y286	52.4482	8.21	No	Yes	1	8	9
39	R:R:I115	R:R:Y286	26.6404	3.63	No	Yes	0	8	9
40	R:R:I115	R:R:Y59	29.1176	2.42	No	Yes	0	8	7
41	R:R:D118	R:R:Y59	20.1201	4.6	Yes	Yes	0	8	7
42	R:R:S73	R:R:W77	22.5849	6.18	No	Yes	2	6	6
43	R:R:L100	R:R:S73	24.594	4.5	No	No	0	5	6
44	R:R:L100	R:R:N104	23.2933	5.49	No	No	0	5	8
45	R:R:E149	R:R:N104	21.9843	5.26	No	No	0	7	8
46	R:R:E149	R:R:I107	11.1143	9.56	No	Yes	0	7	7
47	R:R:F173	R:R:V162	11.3173	5.24	Yes	No	0	3	5
48	R:R:Q95	R:R:V162	10.0994	4.3	No	No	0	7	5
49	R:R:F156	R:R:F173	12.4068	3.22	No	Yes	0	4	3
50	R:R:E103	R:R:F156	12.6926	7	No	No	0	5	4
51	R:R:H245	R:R:Y244	13.7697	8.71	No	Yes	0	8	7
52	R:R:L248	R:R:Y244	15.4474	4.69	No	Yes	0	5	7
53	R:R:F241	R:R:V109	11.6736	2.62	Yes	No	8	9	7
54	R:R:P197	R:R:V109	11.8807	3.53	No	No	0	9	7
55	R:R:F237	R:R:F241	32.9536	7.5	Yes	Yes	8	9	9
56	R:R:F237	R:R:L201	30.4888	4.87	Yes	No	0	9	8
57	R:R:L201	R:R:S116	29.7804	3	No	No	0	8	9
58	R:R:S116	R:R:Y205	28.6868	10.17	No	Yes	1	9	8
59	R:R:I208	R:R:Y120	19.4325	3.63	Yes	Yes	1	8	8
60	R:R:I208	R:R:Y205	38.2022	2.42	Yes	Yes	1	8	8
61	R:R:E174	R:R:Y268	23.0613	4.49	Yes	Yes	3	5	5
62	R:R:R251	R:R:Y268	19.9337	12.35	Yes	Yes	0	5	5
63	R:R:L248	R:R:N186	11.1599	13.73	No	No	6	5	4
64	R:R:N186	R:R:S252	14.5775	8.94	No	No	0	4	6
65	R:R:S252	R:R:Y187	11.7274	6.36	No	No	0	6	4
66	R:R:T233	R:R:Y205	20.6711	4.99	No	Yes	1	7	8
67	R:R:T233	R:R:Y286	20.1201	3.75	No	Yes	1	7	9
68	R:R:I208	R:R:V212	16.5907	1.54	Yes	Yes	1	8	8
69	R:R:K223	R:R:V212	15.3273	1.52	No	Yes	0	7	8
70	R:R:D67	R:R:L63	16.0771	2.71	Yes	Yes	1	9	9
71	R:R:L112	R:R:L63	16.367	2.77	No	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9BI6_nogp

PDB Summary
PDB	9BI6_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.59
Number of Linked Nodes	268
Number of Links	313
Number of Hubs	45
Number of Links mediated by Hubs	161
Number of Communities	9
Number of Nodes involved in Communities	66
Number of Links involved in Communities	88

Path Summary
Number Of Nodes in MetaPath	72
Number Of Links MetaPath	71
Number of Shortest Paths	53912
Length Of Smallest Path	3
Average Path Length	13.7252
Length of Longest Path	30
Minimum Path Strength	1.23
Average Path Strength	5.27326
Maximum Path Strength	18.185
Minimum Path Correlation	0.7
Average Path Correlation	0.926348
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	47.8248
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.9642
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q15743
Sequence	>9BI6_nogp_Chain_R C T I D H T I H Q T L A P V V Y V T V L V V G F P A N C L S L Y F G Y L Q I K A R N E L G V Y L C N L T V A D L F Y I C S L P F W L Q Y V L Q H D N W S H G D L S C Q V C G I L L Y E N I Y I S V G F L C C I S V D R Y L A V A H P F R F H Q F R T L K A A V G V S V V I W A K E L L T S I Y F L M H E E V I E D E N Q H R V C F E H Y P I Q A W Q R A I N Y Y R F L V G F L F P I C L L L A S Y Q G I L R A V R R S H G T Q K S R K D Q I Q R L V L S T V V I F L A C F L P Y H V L L L V R S V W E A S C D F A K G V F N A Y H F S L L L T S F N C V A D P V L Y C F V S E T T H R D L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9BI6	A	Orphan	Orphan	GPR68	Homo sapiens	-	-	chim(Gs-CtGq)/β1/γ2	2.9	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BI6 (No Gprot)	A	Orphan	Orphan	GPR68	Homo sapiens	-	-		2.9	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BHM	A	Orphan	Orphan	GPR68	Homo sapiens	-	-	Gs/β1	2.9	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BHM (No Gprot)	A	Orphan	Orphan	GPR68	Homo sapiens	-	-		2.9	2025-01-22	doi.org/10.1016/j.cell.2024.11.036

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9BI6_nogp.zip

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