psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C13	R:R:C258	7.28	No	No	0	7	5
2	R:R:E166	R:R:T14	2.82	No	No	0	3	3
3	R:R:I15	R:R:Y176	10.88	Yes	No	2	2	6
4	R:R:I15	R:R:K262	7.27	Yes	No	0	2	3
5	R:R:F265	R:R:I15	6.28	Yes	Yes	2	3	2
6	R:R:D16	R:R:T18	2.89	No	No	0	3	3
7	R:R:H17	R:R:H20	4.78	Yes	No	2	4	4
8	R:R:H17	R:R:Q21	8.65	Yes	No	2	4	4
9	R:R:H17	R:R:H84	4.78	Yes	No	2	4	3
10	R:R:D85	R:R:H17	12.61	Yes	Yes	2	4	4
11	R:R:I19	R:R:T22	3.04	No	No	0	3	3
12	R:R:I19	R:R:N266	11.33	No	No	0	3	1
13	R:R:H20	R:R:Q21	4.95	No	No	2	4	4
14	R:R:F265	R:R:H20	3.39	Yes	No	2	3	4
15	R:R:D85	R:R:Q21	3.92	Yes	No	2	4	4
16	R:R:L23	R:R:T22	7.37	No	No	0	5	3
17	R:R:A24	R:R:Y28	2.67	No	Yes	5	5	8
18	R:R:A24	R:R:V81	3.39	No	No	5	5	5
19	R:R:P25	R:R:V81	3.53	No	No	0	6	5
20	R:R:L273	R:R:V27	10.43	No	No	0	5	5
21	R:R:F277	R:R:V27	2.62	No	No	0	4	5
22	R:R:V81	R:R:Y28	2.52	No	Yes	5	5	8
23	R:R:L74	R:R:V31	2.98	Yes	No	0	7	7
24	R:R:F277	R:R:V31	2.62	No	No	0	4	7
25	R:R:V280	R:R:V34	3.21	No	No	0	7	6
26	R:R:F36	R:R:P37	5.78	No	No	0	6	5
27	R:R:N39	R:R:T64	2.92	Yes	No	0	9	8
28	R:R:D67	R:R:N39	6.73	Yes	Yes	0	9	9
29	R:R:L68	R:R:N39	4.12	No	Yes	0	7	9
30	R:R:I71	R:R:N39	2.83	No	Yes	0	5	9
31	R:R:N39	R:R:P283	6.52	Yes	No	0	9	9
32	R:R:S42	R:R:T64	7.99	No	No	0	8	8
33	R:R:P283	R:R:S42	3.56	No	No	0	9	8
34	R:R:C287	R:R:S42	6.89	No	No	0	6	8
35	R:R:L43	R:R:T64	5.9	No	No	0	6	8
36	R:R:L48	R:R:Y44	4.69	No	No	0	4	4
37	R:R:C287	R:R:F45	6.98	No	Yes	0	6	6
38	R:R:F288	R:R:F45	4.29	No	Yes	0	7	6
39	R:R:F45	R:R:T293	5.19	Yes	No	0	6	8
40	R:R:D296	R:R:L48	4.07	No	No	0	4	4
41	R:R:N54	R:R:Q49	3.96	No	Yes	0	7	4
42	R:R:Q49	R:R:T292	2.83	Yes	No	0	4	6
43	R:R:E55	R:R:Y59	15.71	No	Yes	6	6	7
44	R:R:D118	R:R:E55	6.5	No	No	0	8	6
45	R:R:A138	R:R:E55	4.53	No	No	6	7	6
46	R:R:I115	R:R:L56	2.85	No	No	0	8	7
47	R:R:D118	R:R:L56	5.43	No	No	0	8	7
48	R:R:A138	R:R:V58	5.09	No	No	0	7	6
49	R:R:C114	R:R:Y59	6.72	No	Yes	0	6	7
50	R:R:A138	R:R:Y59	5.34	No	Yes	6	7	7
51	R:R:V141	R:R:Y59	3.79	No	Yes	0	4	7
52	R:R:F111	R:R:N62	12.08	Yes	No	1	7	9
53	R:R:N62	R:R:S142	8.94	No	No	1	9	6
54	R:R:N62	R:R:W146	6.78	No	Yes	1	9	9
55	R:R:D67	R:R:L63	2.71	Yes	Yes	1	9	9
56	R:R:L63	R:R:S108	3	Yes	No	0	9	9
57	R:R:D282	R:R:L63	6.79	Yes	Yes	1	9	9
58	R:R:F69	R:R:V65	2.62	No	No	0	7	5
59	R:R:A66	R:R:I107	3.25	No	Yes	1	8	7
60	R:R:A66	R:R:W146	2.59	No	Yes	1	8	9
61	R:R:C279	R:R:D67	6.22	No	Yes	0	8	9
62	R:R:D282	R:R:D67	6.65	Yes	Yes	1	9	9
63	R:R:L101	R:R:Y70	4.69	No	Yes	0	6	6
64	R:R:N104	R:R:Y70	11.63	No	Yes	0	8	6
65	R:R:S276	R:R:Y70	7.63	No	Yes	0	7	6
66	R:R:C279	R:R:Y70	5.38	No	Yes	0	8	6
67	R:R:C279	R:R:I71	4.91	No	No	0	8	5
68	R:R:L100	R:R:S73	3	No	No	0	5	6
69	R:R:C97	R:R:F76	5.59	No	No	0	5	6
70	R:R:W77	R:R:Y80	4.82	Yes	No	0	6	5
71	R:R:C97	R:R:W77	2.61	No	Yes	0	5	6
72	R:R:L101	R:R:W77	18.22	No	Yes	0	6	6
73	R:R:C172	R:R:W77	6.53	No	Yes	0	9	6
74	R:R:L78	R:R:L82	5.54	No	No	0	7	4
75	R:R:Q79	R:R:Q83	7.68	No	No	0	4	4
76	R:R:H89	R:R:Q79	9.89	No	No	0	7	4
77	R:R:W87	R:R:Y80	7.72	Yes	No	0	9	5
78	R:R:V171	R:R:Y80	2.52	No	No	0	3	5
79	R:R:N86	R:R:Q83	15.85	No	No	7	4	4
80	R:R:Q83	R:R:S88	7.22	No	No	7	4	3
81	R:R:D85	R:R:H84	23.95	Yes	No	2	4	3
82	R:R:H169	R:R:H84	11.94	Yes	No	2	2	3
83	R:R:D85	R:R:H169	18.91	Yes	Yes	2	4	2
84	R:R:N86	R:R:S88	5.96	No	No	7	4	3
85	R:R:S93	R:R:W87	3.71	No	Yes	0	5	9
86	R:R:C94	R:R:W87	7.84	No	Yes	0	9	9
87	R:R:C172	R:R:W87	7.84	No	Yes	0	9	9
88	R:R:D91	R:R:L92	6.79	No	No	0	3	2
89	R:R:L92	R:R:S93	4.5	No	No	0	2	5
90	R:R:L157	R:R:Q95	2.66	No	No	0	4	7
91	R:R:E161	R:R:Q95	5.1	No	No	0	4	7
92	R:R:F173	R:R:G98	6.02	Yes	No	0	3	5
93	R:R:I99	R:R:S153	3.1	No	No	0	5	6
94	R:R:F156	R:R:I99	2.51	Yes	No	0	4	5
95	R:R:L101	R:R:Y102	7.03	No	Yes	0	6	5
96	R:R:F173	R:R:Y102	13.41	Yes	Yes	0	3	5
97	R:R:E174	R:R:Y102	6.73	No	Yes	0	5	5
98	R:R:Y102	R:R:Y268	3.97	Yes	Yes	0	5	5
99	R:R:L272	R:R:Y102	4.69	No	Yes	0	6	5
100	R:R:E103	R:R:Y106	5.61	No	Yes	3	5	7
101	R:R:E103	R:R:F156	10.49	No	Yes	0	5	4
102	R:R:E103	R:R:R189	15.12	No	No	3	5	5
103	R:R:I105	R:R:Y106	9.67	No	Yes	0	7	7
104	R:R:F241	R:R:I105	6.28	Yes	No	0	9	7
105	R:R:V109	R:R:Y106	2.52	Yes	Yes	3	7	7
106	R:R:R189	R:R:Y106	8.23	No	Yes	3	5	7
107	R:R:H245	R:R:Y106	6.53	Yes	Yes	0	8	7
108	R:R:F111	R:R:I107	2.51	Yes	Yes	1	7	7
109	R:R:I107	R:R:I145	2.94	Yes	No	1	7	6
110	R:R:I107	R:R:W146	3.52	Yes	Yes	1	7	9
111	R:R:E149	R:R:I107	10.93	No	Yes	1	7	7
112	R:R:N278	R:R:S108	2.98	No	No	0	9	9
113	R:R:F237	R:R:V109	3.93	Yes	Yes	3	9	7
114	R:R:F241	R:R:V109	3.93	Yes	Yes	3	9	7
115	R:R:F111	R:R:S142	5.28	Yes	No	1	7	6
116	R:R:F111	R:R:I145	7.54	Yes	No	1	7	6
117	R:R:F111	R:R:W146	4.01	Yes	Yes	1	7	9
118	R:R:D282	R:R:L112	5.43	Yes	No	0	9	8
119	R:R:L112	R:R:Y286	8.21	No	Yes	0	8	9
120	R:R:C113	R:R:P197	3.77	No	No	0	7	9
121	R:R:C113	R:R:L200	3.17	No	No	0	7	6
122	R:R:I115	R:R:R119	6.26	No	No	4	8	9
123	R:R:I115	R:R:Y286	4.84	No	Yes	4	8	9
124	R:R:L201	R:R:S116	3	No	No	0	8	9
125	R:R:S116	R:R:S204	6.52	No	No	4	9	6
126	R:R:S116	R:R:Y205	12.72	No	Yes	4	9	8
127	R:R:L200	R:R:V117	4.47	No	No	0	6	5
128	R:R:D118	R:R:R133	4.76	No	No	0	8	7
129	R:R:R119	R:R:Y205	5.14	No	Yes	4	9	8
130	R:R:R119	R:R:Y286	4.12	No	Yes	4	9	9
131	R:R:A124	R:R:Y120	4	No	Yes	8	7	8
132	R:R:H125	R:R:Y120	6.53	Yes	Yes	8	6	8
133	R:R:G207	R:R:Y120	2.9	No	Yes	0	3	8
134	R:R:I208	R:R:Y120	3.63	No	Yes	0	8	8
135	R:R:F129	R:R:L121	3.65	No	No	0	6	5
136	R:R:I208	R:R:V123	6.14	No	No	0	8	8
137	R:R:A124	R:R:H125	2.93	No	Yes	8	7	6
138	R:R:F129	R:R:H125	3.39	No	Yes	0	6	6
139	R:R:F129	R:R:R128	3.21	No	No	0	6	4
140	R:R:F132	R:R:Q131	8.2	No	No	0	3	4
141	R:R:K148	R:R:V144	3.04	No	No	0	4	3
142	R:R:E149	R:R:W146	3.27	No	Yes	1	7	9
143	R:R:E149	R:R:T152	4.23	No	No	0	7	4
144	R:R:I154	R:R:L151	4.28	No	No	0	5	4
145	R:R:F156	R:R:Y155	3.09	Yes	No	0	4	8
146	R:R:W181	R:R:Y155	2.89	No	No	0	3	8
147	R:R:I185	R:R:Y155	6.04	No	No	0	5	8
148	R:R:F156	R:R:F173	3.22	Yes	Yes	0	4	3
149	R:R:H159	R:R:M158	5.25	No	No	0	4	4
150	R:R:H159	R:R:W181	27.51	No	No	0	4	3
151	R:R:E161	R:R:F173	13.99	No	Yes	0	4	3
152	R:R:I163	R:R:V171	4.61	No	No	0	1	3
153	R:R:E164	R:R:R170	4.65	No	No	0	1	4
154	R:R:D165	R:R:H169	5.04	No	Yes	0	2	2
155	R:R:D165	R:R:V171	5.84	No	No	0	2	3
156	R:R:H169	R:R:N167	2.55	Yes	No	0	2	4
157	R:R:Q168	R:R:R170	12.85	No	No	0	4	4
158	R:R:C172	R:R:F173	2.79	No	Yes	0	9	3
159	R:R:E174	R:R:H269	11.08	No	No	0	5	4
160	R:R:H175	R:R:P177	12.2	No	No	0	4	4
161	R:R:H175	R:R:Q179	6.18	No	No	0	4	1
162	R:R:F265	R:R:Y176	7.22	Yes	No	2	3	6
163	R:R:I178	R:R:Q182	8.23	No	No	0	4	4
164	R:R:I178	R:R:R183	11.27	No	No	0	4	2
165	R:R:I178	R:R:R251	8.77	No	No	0	4	5
166	R:R:Q179	R:R:W181	4.38	No	No	0	1	3
167	R:R:N186	R:R:Q182	5.28	No	No	0	4	4
168	R:R:A256	R:R:R183	2.77	No	No	0	1	2
169	R:R:I185	R:R:R189	3.76	No	No	0	5	5
170	R:R:L248	R:R:N186	12.36	No	No	0	5	4
171	R:R:N186	R:R:S252	4.47	No	No	0	4	6
172	R:R:S252	R:R:Y187	5.09	No	No	0	6	4
173	R:R:V253	R:R:Y187	6.31	No	No	0	4	4
174	R:R:F190	R:R:H245	5.66	No	Yes	0	6	8
175	R:R:F190	R:R:L249	21.92	No	No	0	6	5
176	R:R:G193	R:R:P197	4.06	No	No	0	5	9
177	R:R:F194	R:R:F237	4.29	Yes	Yes	3	8	9
178	R:R:F194	R:R:L238	3.65	Yes	No	3	8	5
179	R:R:F194	R:R:L242	7.31	Yes	Yes	3	8	4
180	R:R:F194	R:R:H245	14.71	Yes	Yes	0	8	8
181	R:R:F196	R:R:P197	2.89	No	No	0	5	9
182	R:R:F237	R:R:L201	3.65	Yes	No	0	9	8
183	R:R:S204	R:R:Y205	5.09	No	Yes	4	6	8
184	R:R:V230	R:R:Y205	8.83	No	Yes	0	7	8
185	R:R:V234	R:R:Y205	2.52	No	Yes	0	7	8
186	R:R:Q206	R:R:R210	3.5	No	No	0	4	3
187	R:R:L209	R:R:Q227	2.66	Yes	No	0	5	6
188	R:R:K223	R:R:T218	6.01	No	No	0	7	3
189	R:R:K220	R:R:Q219	6.78	No	No	0	4	4
190	R:R:E291	R:R:R222	3.49	No	No	0	6	5
191	R:R:L231	R:R:Q227	2.66	No	No	0	4	6
192	R:R:R228	R:R:S232	7.91	No	No	0	6	6
193	R:R:L285	R:R:T233	7.37	No	No	0	8	7
194	R:R:A281	R:R:I236	3.25	No	No	0	6	6
195	R:R:F237	R:R:F241	7.5	Yes	Yes	3	9	9
196	R:R:L238	R:R:L242	2.77	No	Yes	3	5	4
197	R:R:F241	R:R:H245	3.39	Yes	Yes	0	9	8
198	R:R:F241	R:R:T275	5.19	Yes	No	0	9	7
199	R:R:F241	R:R:N278	3.62	Yes	No	0	9	9
200	R:R:L242	R:R:P243	3.28	Yes	No	0	4	9
201	R:R:L242	R:R:V246	2.98	Yes	No	0	4	5
202	R:R:L248	R:R:Y244	4.69	No	Yes	0	5	7
203	R:R:Y244	R:R:Y268	10.92	Yes	Yes	0	7	5
204	R:R:S271	R:R:Y244	7.63	No	Yes	0	7	7
205	R:R:L272	R:R:Y244	4.69	No	Yes	0	6	7
206	R:R:A267	R:R:L247	4.73	No	No	0	5	4
207	R:R:L247	R:R:S271	7.51	No	No	0	4	7
208	R:R:L249	R:R:S252	3	No	No	0	5	6
209	R:R:E255	R:R:V250	4.28	No	No	0	3	5
210	R:R:R251	R:R:Y268	18.52	No	Yes	0	5	5
211	R:R:E255	R:R:F260	9.33	No	No	0	3	1
212	R:R:F260	R:R:S257	6.61	No	No	0	1	5
213	R:R:G263	R:R:K262	3.49	No	No	0	2	3
214	R:R:F265	R:R:H269	23.76	Yes	No	0	3	4
215	R:R:H269	R:R:Y268	4.36	No	Yes	0	4	5
216	R:R:D282	R:R:N278	14.81	Yes	No	0	9	9
217	R:R:S290	R:R:T293	6.4	No	No	0	8	8
218	R:R:H294	R:R:T293	4.11	No	No	0	8	8
219	R:R:T233	R:R:Y286	2.5	No	Yes	0	7	9
220	R:R:S73	R:R:W77	2.47	No	Yes	0	6	6
221	R:R:F111	R:R:L63	2.44	Yes	Yes	1	7	9
222	R:R:F190	R:R:L191	2.44	No	No	0	6	4
223	R:R:F277	R:R:L274	2.44	No	No	0	4	7
224	R:R:I208	R:R:Y205	2.42	No	Yes	0	8	8
225	R:R:L74	R:R:Y28	2.34	Yes	Yes	0	7	8
226	R:R:L78	R:R:Y28	2.34	No	Yes	0	7	8
227	R:R:L74	R:R:Y70	2.34	Yes	Yes	0	7	6
228	R:R:Q219	R:R:R222	2.34	No	No	0	4	5
229	R:R:F76	R:R:H89	2.26	No	No	0	6	7
230	R:R:H130	R:R:R133	2.26	No	No	0	5	7
231	R:R:F45	R:R:Y44	2.06	Yes	No	0	6	4
232	R:R:Y44	R:R:Y47	1.99	No	No	0	4	2
233	R:R:C61	R:R:G46	1.96	No	No	0	6	6
234	R:R:C113	R:R:G110	1.96	No	No	0	7	5
235	R:R:A38	R:R:G35	1.95	No	No	0	7	8
236	R:R:A38	R:R:P283	1.87	No	No	0	7	9
237	R:R:G35	R:R:V34	1.84	No	No	0	8	6
238	R:R:G110	R:R:V109	1.84	No	Yes	0	5	7
239	R:R:G193	R:R:V192	1.84	No	No	0	5	4
240	R:R:A124	R:R:A211	1.79	No	No	0	7	5
241	R:R:G57	R:R:I50	1.76	No	No	0	7	5
242	R:R:C13	R:R:S12	1.72	No	No	0	7	6
243	R:R:C94	R:R:V162	1.71	No	No	0	9	5
244	R:R:A267	R:R:V264	1.7	No	No	0	5	5
245	R:R:A137	R:R:T134	1.68	No	No	0	1	6
246	R:R:C13	R:R:I15	1.64	No	Yes	0	7	2
247	R:R:L32	R:R:P75	1.64	No	No	0	6	9
248	R:R:G46	R:R:Q49	1.64	No	Yes	0	6	4
249	R:R:G57	R:R:Q49	1.64	No	Yes	0	7	4
250	R:R:L74	R:R:P75	1.64	Yes	No	0	7	9
251	R:R:G207	R:R:Q206	1.64	No	No	0	3	4
252	R:R:C240	R:R:I236	1.64	No	No	0	8	6
253	R:R:V29	R:R:V33	1.6	No	No	0	6	5
254	R:R:V139	R:R:V143	1.6	No	No	0	3	4
255	R:R:S215	R:R:T218	1.6	No	No	0	5	3
256	R:R:V246	R:R:V250	1.6	No	No	0	5	5
257	R:R:S290	R:R:T292	1.6	No	No	0	8	6
258	R:R:T30	R:R:V26	1.59	No	No	0	4	5
259	R:R:T30	R:R:V29	1.59	No	No	0	4	6
260	R:R:T30	R:R:V34	1.59	No	No	0	4	6
261	R:R:C199	R:R:L195	1.59	No	No	0	3	4
262	R:R:G217	R:R:H216	1.59	No	No	0	4	3
263	R:R:I226	R:R:V230	1.54	No	No	0	7	7
264	R:R:H125	R:R:P126	1.53	Yes	No	0	6	8
265	R:R:I19	R:R:T18	1.52	No	No	0	3	3
266	R:R:L43	R:R:V65	1.49	No	No	0	6	5
267	R:R:L100	R:R:V96	1.49	No	No	0	5	4
268	R:R:L202	R:R:V234	1.49	No	No	0	3	7
269	R:R:L209	R:R:V212	1.49	Yes	No	0	5	8
270	R:R:L209	R:R:V230	1.49	Yes	No	0	5	7
271	R:R:L229	R:R:V289	1.49	No	No	0	7	6
272	R:R:L285	R:R:V289	1.49	No	No	0	8	6
273	R:R:D224	R:R:S221	1.47	No	No	0	5	3
274	R:R:I198	R:R:L238	1.43	No	No	0	6	5
275	R:R:I236	R:R:L285	1.43	No	No	0	6	8
276	R:R:L56	R:R:L60	1.38	No	No	0	7	7
277	R:R:A122	R:R:R133	1.38	No	No	0	8	7
278	R:R:L191	R:R:L195	1.38	No	No	0	4	4
279	R:R:R170	R:R:V162	1.31	No	No	0	4	5
280	R:R:D224	R:R:Q225	1.31	No	No	0	5	7
281	R:R:R222	R:R:T218	1.29	No	No	0	5	3
282	R:R:F36	R:R:I71	1.26	No	No	0	6	5
283	R:R:V192	R:R:Y188	1.26	No	No	0	4	3
284	R:R:V253	R:R:W254	1.23	No	No	0	4	2
285	R:R:F288	R:R:L41	1.22	No	No	0	7	6
286	R:R:L209	R:R:R213	1.21	Yes	No	0	5	4
287	R:R:F265	R:R:N266	1.21	Yes	No	0	3	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I15	6.5175	4	2	2
2	R:R:H17	7.705	4	2	4
3	R:R:Y28	2.4675	4	5	8
4	R:R:N39	4.624	5	0	9
5	R:R:F45	4.63	4	0	6
6	R:R:Q49	2.5175	4	0	4
7	R:R:Y59	7.89	4	6	7
8	R:R:L63	3.735	4	1	9
9	R:R:D67	5.5775	4	1	9
10	R:R:Y70	6.334	5	0	6
11	R:R:L74	2.325	4	0	7
12	R:R:W77	6.93	5	0	6
13	R:R:D85	14.8475	4	2	4
14	R:R:W87	6.7775	4	0	9
15	R:R:Y102	7.166	5	0	5
16	R:R:Y106	6.512	5	3	7
17	R:R:I107	4.63	5	1	7
18	R:R:V109	3.055	4	3	7
19	R:R:F111	5.64333	6	1	7
20	R:R:Y120	4.265	4	8	8
21	R:R:H125	3.595	4	8	6
22	R:R:W146	4.034	5	1	9
23	R:R:F156	4.8275	4	0	4
24	R:R:H169	9.61	4	2	2
25	R:R:F173	7.886	5	0	3
26	R:R:F194	7.49	4	3	8
27	R:R:Y205	6.12	6	4	8
28	R:R:L209	1.7125	4	0	5
29	R:R:F237	4.8425	4	3	9
30	R:R:F241	4.985	6	3	9
31	R:R:L242	4.085	4	3	4
32	R:R:Y244	6.9825	4	0	7
33	R:R:H245	7.5725	4	0	8
34	R:R:F265	8.372	5	2	3
35	R:R:Y268	9.4425	4	0	5
36	R:R:D282	8.42	4	1	9
37	R:R:Y286	4.9175	4	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F265	R:R:I15	17.3712	6.28	Yes	Yes	2	3	2
2	R:R:F265	R:R:N266	17.3987	1.21	Yes	No	0	3	1
3	R:R:I19	R:R:N266	14.5211	11.33	No	No	0	3	1
4	R:R:F265	R:R:H20	11.0744	3.39	Yes	No	2	3	4
5	R:R:L74	R:R:Y70	22.2911	2.34	Yes	Yes	0	7	6
6	R:R:L101	R:R:Y70	92.9781	4.69	No	Yes	0	6	6
7	R:R:L101	R:R:Y102	65.657	7.03	No	Yes	0	6	5
8	R:R:E174	R:R:Y102	25.4027	6.73	No	Yes	0	5	5
9	R:R:E174	R:R:H269	24.2003	11.08	No	No	0	5	4
10	R:R:F265	R:R:H269	48.474	23.76	Yes	No	0	3	4
11	R:R:Y102	R:R:Y268	39.8412	3.97	Yes	Yes	0	5	5
12	R:R:H269	R:R:Y268	26.9356	4.36	No	Yes	0	4	5
13	R:R:C279	R:R:Y70	100	5.38	No	Yes	0	8	6
14	R:R:C279	R:R:D67	68.4566	6.22	No	Yes	0	8	9
15	R:R:D67	R:R:N39	63.1924	6.73	Yes	Yes	0	9	9
16	R:R:N39	R:R:P283	50.039	6.52	Yes	No	0	9	9
17	R:R:A38	R:R:P283	15.3793	1.87	No	No	0	7	9
18	R:R:A38	R:R:G35	13.4885	1.95	No	No	0	7	8
19	R:R:G35	R:R:V34	11.5884	1.84	No	No	0	8	6
20	R:R:C279	R:R:I71	35.1508	4.91	No	No	0	8	5
21	R:R:I71	R:R:N39	33.907	2.83	No	Yes	0	5	9
22	R:R:N39	R:R:T64	41.0666	2.92	Yes	No	0	9	8
23	R:R:S42	R:R:T64	34.2375	7.99	No	No	0	8	8
24	R:R:P283	R:R:S42	34.6735	3.56	No	No	0	9	8
25	R:R:C287	R:R:S42	65.0191	6.89	No	No	0	6	8
26	R:R:C287	R:R:F45	61.4438	6.98	No	Yes	0	6	6
27	R:R:F45	R:R:Y44	14.489	2.06	Yes	No	0	6	4
28	R:R:F45	R:R:T293	36.5047	5.19	Yes	No	0	6	8
29	R:R:S290	R:R:T293	29.5746	6.4	No	No	0	8	8
30	R:R:S290	R:R:T292	25.9167	1.6	No	No	0	8	6
31	R:R:Q49	R:R:T292	22.2406	2.83	Yes	No	0	4	6
32	R:R:D282	R:R:D67	56.1705	6.65	Yes	Yes	1	9	9
33	R:R:D282	R:R:L112	48.3317	5.43	Yes	No	0	9	8
34	R:R:L112	R:R:Y286	47.1155	8.21	No	Yes	0	8	9
35	R:R:I115	R:R:Y286	17.2059	4.84	No	Yes	4	8	9
36	R:R:I115	R:R:L56	19.6338	2.85	No	No	0	8	7
37	R:R:D118	R:R:L56	16.568	5.43	No	No	0	8	7
38	R:R:D67	R:R:L63	11.9923	2.71	Yes	Yes	1	9	9
39	R:R:F111	R:R:L63	25.4303	2.44	Yes	Yes	1	7	9
40	R:R:L101	R:R:W77	35.0314	18.22	No	Yes	0	6	6
41	R:R:C97	R:R:W77	11.0377	2.61	No	Yes	0	5	6
42	R:R:W77	R:R:Y80	17.7016	4.82	Yes	No	0	6	5
43	R:R:F173	R:R:Y102	32.0804	13.41	Yes	Yes	0	3	5
44	R:R:C172	R:R:F173	13.3232	2.79	No	Yes	0	9	3
45	R:R:C172	R:R:W87	15.3151	7.84	No	Yes	0	9	9
46	R:R:C94	R:R:W87	11.9739	7.84	No	Yes	0	9	9
47	R:R:F156	R:R:F173	35.2012	3.22	Yes	Yes	0	4	3
48	R:R:L272	R:R:Y102	10.6889	4.69	No	Yes	0	6	5
49	R:R:Y244	R:R:Y268	11.4278	10.92	Yes	Yes	0	7	5
50	R:R:E103	R:R:F156	34.0814	10.49	No	Yes	0	5	4
51	R:R:E103	R:R:Y106	34.7974	5.61	No	Yes	3	5	7
52	R:R:V109	R:R:Y106	25.9443	2.52	Yes	Yes	3	7	7
53	R:R:F241	R:R:V109	13.8189	3.93	Yes	Yes	3	9	7
54	R:R:H245	R:R:Y106	15.2462	6.53	Yes	Yes	0	8	7
55	R:R:F241	R:R:H245	22.7087	3.39	Yes	Yes	0	9	8
56	R:R:D282	R:R:N278	37.9458	14.81	Yes	No	0	9	9
57	R:R:F237	R:R:V109	14.7827	3.93	Yes	Yes	3	9	7
58	R:R:C113	R:R:G110	12.5522	1.96	No	No	0	7	5
59	R:R:G110	R:R:V109	14.0805	1.84	No	Yes	0	5	7
60	R:R:R119	R:R:Y286	20.6021	4.12	No	Yes	4	9	9
61	R:R:F237	R:R:L201	22.8051	3.65	Yes	No	0	9	8
62	R:R:L201	R:R:S116	21.7862	3	No	No	0	8	9
63	R:R:R119	R:R:Y205	24.058	5.14	No	Yes	4	9	8
64	R:R:S116	R:R:Y205	20.1983	12.72	No	Yes	4	9	8
65	R:R:I208	R:R:Y120	18.1192	3.63	No	Yes	0	8	8
66	R:R:I208	R:R:Y205	21.2171	2.42	No	Yes	0	8	8
67	R:R:F156	R:R:Y155	15.875	3.09	Yes	No	0	4	8
68	R:R:W181	R:R:Y155	19.6016	2.89	No	No	0	3	8
69	R:R:L249	R:R:S252	10.4043	3	No	No	0	5	6
70	R:R:F190	R:R:L249	11.157	21.92	No	No	0	6	5
71	R:R:F194	R:R:H245	14.2687	14.71	Yes	Yes	0	8	8
72	R:R:F194	R:R:L242	13.874	7.31	Yes	Yes	3	8	4
73	R:R:V230	R:R:Y205	11.3268	8.83	No	Yes	0	7	8
74	R:R:T233	R:R:Y286	11.3268	2.5	No	Yes	0	7	9
75	R:R:L242	R:R:V246	10.0005	2.98	Yes	No	0	4	5
76	R:R:S271	R:R:Y244	12.2034	7.63	No	Yes	0	7	7
77	R:R:V171	R:R:Y80	11.2672	2.52	No	No	0	3	5
78	R:R:C172	R:R:W77	12.8368	6.53	No	Yes	0	9	6
79	R:R:F241	R:R:N278	44.8804	3.62	Yes	No	0	9	9
80	R:R:F237	R:R:F241	10.2345	7.5	Yes	Yes	3	9	9
81	R:R:F190	R:R:H245	15.618	5.66	No	Yes	0	6	8
82	R:R:F194	R:R:F237	10.8266	4.29	Yes	Yes	3	8	9
83	R:R:R189	R:R:Y106	11.0698	8.23	No	Yes	3	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8Z5H_nogp

PDB Summary
PDB	8Z5H_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.51
Number of Linked Nodes	261
Number of Links	287
Number of Hubs	37
Number of Links mediated by Hubs	136
Number of Communities	8
Number of Nodes involved in Communities	47
Number of Links involved in Communities	60

Path Summary
Number Of Nodes in MetaPath	84
Number Of Links MetaPath	83
Number of Shortest Paths	54907
Length Of Smallest Path	3
Average Path Length	12.6983
Length of Longest Path	23
Minimum Path Strength	1.35
Average Path Strength	5.96586
Maximum Path Strength	17.42
Minimum Path Correlation	0.7
Average Path Correlation	0.922757
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.55556
Average % Of Corr. Nodes	49.0609
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.3166
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cellular response to stimulus • positive regulation of cell communication • regulation of localization • establishment of protein localization • regulation of cellular process • nitrogen compound transport • response to stimulus • positive regulation of establishment of protein localization • cell communication • localization • carbohydrate homeostasis • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • regulation of biological process • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • intracellular glucose homeostasis • protein secretion • establishment of localization • cellular response to oxygen-containing compound • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • chemical homeostasis • response to glucose • response to chemical • glucose homeostasis • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • signaling • homeostatic process • positive regulation of biological process • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • amide transport • signal release • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • biological regulation • regulation of establishment of protein localization • export from cell • cell-cell signaling • response to oxygen-containing compound • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • cellular response to chemical stimulus • cellular homeostasis • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • cellular process • insulin secretion • positive regulation of signaling • developmental process • myeloid leukocyte differentiation • cellular developmental process • hemopoiesis • cell development • mononuclear cell differentiation • myeloid cell differentiation • cell differentiation • anatomical structure development • monocyte differentiation • leukocyte differentiation • multicellular organismal process • regulation of leukocyte differentiation • regulation of cell differentiation • regulation of cell development • positive regulation of developmental process • multicellular organism development • skeletal system development • regulation of immune system process • positive regulation of immune system process • regulation of osteoclast development • system development • positive regulation of cell development • regulation of myeloid leukocyte differentiation • osteoclast development • positive regulation of myeloid leukocyte differentiation • positive regulation of multicellular organismal process • regulation of developmental process • positive regulation of osteoclast differentiation • regulation of osteoclast differentiation • positive regulation of cell differentiation • positive regulation of hemopoiesis • bone cell development • osteoclast differentiation • regulation of multicellular organismal process • bone development • positive regulation of osteoclast development • regulation of multicellular organismal development • regulation of myeloid cell differentiation • animal organ development • immune system process • myeloid cell development • positive regulation of myeloid cell differentiation • regulation of hemopoiesis • positive regulation of leukocyte differentiation • defense response • response to stress • inflammatory response • G protein-coupled receptor signaling pathway • signal transduction • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to abiotic stimulus • cellular response to environmental stimulus • negative regulation of biological process • negative regulation of cellular process • negative regulation of cell differentiation • negative regulation of hemopoiesis • negative regulation of monocyte differentiation • regulation of monocyte differentiation • negative regulation of leukocyte differentiation • negative regulation of developmental process • negative regulation of myeloid cell differentiation • negative regulation of myeloid leukocyte differentiation • negative regulation of cell development • negative regulation of immune system process • negative regulation of multicellular organismal process • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q15743
Sequence	>8Z5H_nogp_Chain_R S C T I D H T I H Q T L A P V V Y V T V L V V G F P A N C L S L Y F G Y L Q I K A R N E L G V Y L C N L T V A D L F Y I C S L P F W L Q Y V L Q H D N W S H G D L S C Q V C G I L L Y E N I Y I S V G F L C C I S V D R Y L A V A H P F R F H Q F R T L K A A V G V S V V I W A K E L L T S I Y F L M H E E V I E D E N Q H R V C F E H Y P I Q A W Q R A I N Y Y R F L V G F L F P I C L L L A S Y Q G I L R A V R R S H G T Q K S R K D Q I Q R L V L S T V V I F L A C F L P Y H V L L L V R S V W E A S C D F A K G V F N A Y H F S L L L T S F N C V A D P V L Y C F V S E T T H R D L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9BHM	A	Orphan	Orphan	GPR68	Homo sapiens	-	-	Gs/β1	2.9	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BHM (No Gprot)	A	Orphan	Orphan	GPR68	Homo sapiens	-	-		2.9	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BI6	A	Orphan	Orphan	GPR68	Homo sapiens	-	-	chim(Gs-CtGq)/β1/γ2	2.9	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	9BI6 (No Gprot)	A	Orphan	Orphan	GPR68	Homo sapiens	-	-		2.9	2025-01-22	doi.org/10.1016/j.cell.2024.11.036
	8Z3O	A	Orphan	Orphan	GPR68	Homo sapiens	-	-	-	3.3	2025-04-23	To be published
	8Z5H	A	Orphan	Orphan	GPR68	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.3	2025-04-23	To be published
	8Z5H (No Gprot)	A	Orphan	Orphan	GPR68	Homo sapiens	-	-		3.3	2025-04-23	To be published
	8Z68	A	Orphan	Orphan	GPR68	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.64	2025-04-23	To be published
	8Z68 (No Gprot)	A	Orphan	Orphan	GPR68	Homo sapiens	-	-		2.64	2025-04-23	To be published

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