Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:E33 5.852516
2A:A:V34 6.2535
3A:A:K35 5.0475419
4A:A:L36 5.84437
5A:A:L37 5.94419
6A:A:L39 5.08419
7A:A:K46 4.79754209
8A:A:F191 9.3325435
9A:A:L194 5.7025434
10A:A:H195 6.7375414
11A:A:F196 8.976537
12A:A:K197 9.365416
13A:A:F199 8.174515
14A:A:D200 5.25254209
15A:A:V201 4.3125419
16A:A:Q204 5.71419
17A:A:R208 4.98519
18A:A:K210 7.25714719
19A:A:W211 5.40714719
20A:A:I212 4.8025418
21A:A:F215 6.525619
22A:A:F223 6.706519
23A:A:V225 4.34417
24A:A:Y230 5.87286758
25A:A:D231 8.41459
26A:A:F250 7.14143719
27A:A:C254 4.6625415
28A:A:W258 10.3283615
29A:A:F259 7.1675419
30A:A:L266 4.942519
31A:A:F274 5.9875409
32A:A:K277 5.3925459
33A:A:S281 4.34457
34A:A:C286 4.3425456
35A:A:Y287 6.965657
36A:A:Y290 8.33557
37A:A:Y296 6.641676224
38A:A:Y302 13.74456
39A:A:Q306 8.69455
40A:A:F307 7.755418
41A:A:N311 6.79418
42A:A:R313 4.0975404
43A:A:Y320 6.706507
44A:A:H322 10.60254179
45A:A:F323 5.71254224
46A:A:T324 6.28254179
47A:A:N331 6.725178
48A:A:F336 9.076538
49A:A:V339 4.5475438
50A:A:V342 3.845437
51A:A:K345 4.8925435
52A:A:F354 9.1775405
53B:B:L4 2.8025404
54B:B:L7 2.4325408
55B:B:R22 6.275426
56B:B:L30 4.9775405
57B:B:V40 4.828336123
58B:B:M45 5.1675484
59B:B:H54 9.6065109
60B:B:Y59 8.72833618
61B:B:M61 5.2725476
62B:B:W63 9.678577
63B:B:L79 5.935497
64B:B:I80 11.25754108
65B:B:I81 5.6925497
66B:B:W82 9.262867109
67B:B:N88 7.0325407
68B:B:K89 7.396109
69B:B:H91 7.2525495
70B:B:I93 5.405497
71B:B:L95 5.344598
72B:B:W99 8.015819
73B:B:M101 3.4775419
74B:B:C103 3.0025408
75B:B:Y105 5.082506
76B:B:N110 7.56414
77B:B:Y111 6.19833614
78B:B:C114 4.9775498
79B:B:L117 5.245419
80B:B:C121 4.135418
81B:B:I123 5.002516
82B:B:Y124 5.40833696
83B:B:L126 4.4775405
84B:B:T128 4.9125413
85B:B:V133 5.6875494
86B:B:H142 10.3725419
87B:B:Y145 6.2725818
88B:B:C149 4.2625418
89B:B:F151 4.96857719
90B:B:L152 3.964503
91B:B:Q156 5.275145
92B:B:I157 5.11517
93B:B:V158 4.99405
94B:B:T159 5.82333619
95B:B:S160 4.7975466
96B:B:D163 10.0575419
97B:B:C166 4.235468
98B:B:L168 5.735406
99B:B:W169 9.555618
100B:B:D170 6.8154149
101B:B:F180 8.374567
102B:B:H183 9.26167669
103B:B:D186 7.4275419
104B:B:V187 4.702569
105B:B:F199 7.856569
106B:B:V200 7.76526
107B:B:S201 5.2625469
108B:B:C204 7.095417
109B:B:D205 6.5775469
110B:B:K209 11.6475466
111B:B:L210 5.535405
112B:B:W211 8.13667668
113B:B:F222 9.4375428
114B:B:H225 9.76667629
115B:B:D228 7.344519
116B:B:I229 5.45427
117B:B:I232 5.8625428
118B:B:F235 7.583336156
119B:B:F241 9.11526
120B:B:T243 6.9625428
121B:B:D247 8.846529
122B:B:T249 8.4325426
123B:B:R251 11.525628
124B:B:F253 8.506526
125B:B:R256 8.1975409
126B:B:D258 9.584527
127B:B:M262 6.715404
128B:B:T263 5.5525421
129B:B:Y264 6.702515
130B:B:I269 5.174514
131B:B:R283 7.9425129
132B:B:L284 4.9365125
133B:B:L285 5.4925416
134B:B:Y289 7.14286717
135B:B:D290 9.945416
136B:B:N293 4.9325415
137B:B:C294 4.1525405
138B:B:N295 7.08616
139B:B:W297 6.465418
140B:B:L300 6.164126
141B:B:R304 7.676515
142B:B:H311 9.618589
143B:B:R314 13.625418
144B:B:M325 5.575475
145B:B:V327 3.476586
146B:B:W332 12.51719
147B:B:D333 9.6725489
148B:B:L336 7.04754107
149B:B:K337 9.23486
150B:B:W339 8.97833689
151B:B:N340 9.1785139
152G:G:E22 4.608529
153G:G:Y40 9.7154156
154G:G:D48 7.248509
155G:G:L51 4.813336126
156G:G:V54 3.95476
157G:G:F61 6.696676138
158R:R:I14 2.875404
159R:R:M18 4.94505
160R:R:L37 3.3575448
161R:R:F40 6.2375447
162R:R:P49 2.8375407
163R:R:F55 7.855446
164R:R:L57 4.818549
165R:R:D61 7549
166R:R:R71 5.6775406
167R:R:Y74 9.434115
168R:R:Y75 9.20254115
169R:R:R79 7.4945115
170R:R:F83 7.2125407
171R:R:L92 3.4175406
172R:R:M97 4.698506
173R:R:F105 10.26754197
174R:R:L106 5.005448
175R:R:D112 6.3154188
176R:R:Y114 5.9556169
177R:R:K116 7.0425188
178R:R:H121 6.77536
179R:R:E166 7.4565114
180R:R:I169 9.18254114
181R:R:F181 9.4675405
182R:R:F185 5.7345248
183R:R:K198 4.84254164
184R:R:L209 7.2475432
185R:R:I222 4.262507
186R:R:Y233 8.323336249
187R:R:R240 7.39254115
188R:R:F243 4.90754114
189R:R:L260 5.4654114
190R:R:H261 10.15754115
191R:R:Y268 3.5925407
192R:R:M272 4.83254238
193R:R:D274 5.998549
194R:R:Y278 5.56875849
195R:R:Y279 6.09647
196R:R:F285 6.485449
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:M61 B:B:W63 13.19634.65YesYes767
2B:B:C317 B:B:M61 13.72619.73NoYes076
3B:B:C317 B:B:S316 14.09983.44NoNo079
4B:B:S316 B:B:W332 14.29084.94NoYes099
5A:A:W258 B:B:W332 13.144.69YesYes159
6A:A:N256 A:A:W258 52.644610.17NoYes185
7A:A:I212 A:A:N256 52.67245.66YesNo188
8A:A:I212 A:A:R208 52.70045.01YesYes189
9A:A:L249 A:A:R208 41.42434.86NoYes099
10A:A:F223 A:A:L249 41.45156.09YesNo099
11A:A:F223 A:A:F250 10013.93YesYes199
12A:A:C254 A:A:F250 85.19184.19YesYes159
13A:A:C254 A:A:K317 84.91226.47YesNo157
14A:A:K317 A:A:R313 85.75753.71NoYes074
15A:A:R313 A:A:T316 90.19812.59YesNo043
16A:A:T316 R:R:R214 90.05232.59NoNo034
17A:A:F354 R:R:R214 89.97929.62YesNo054
18A:A:F354 A:A:K345 89.75896.2YesYes055
19A:A:K345 A:A:V342 24.00214.55YesYes357
20A:A:T219 A:A:V342 23.74713.17NoYes377
21A:A:T219 A:A:V34 10.73436.35NoYes375
22A:A:I253 A:A:R208 41.45083.76NoYes189
23A:A:F223 A:A:I253 41.45123.77YesNo198
24A:A:T219 A:A:V339 12.84793.17NoYes378
25A:A:F215 B:B:W99 11.504512.03YesYes199
26A:A:V201 A:A:W211 15.05057.36YesYes199
27A:A:L39 A:A:V201 23.4322.98YesYes199
28A:A:W211 B:B:Y145 45.48745.79YesYes198
29A:A:F223 A:A:L266 14.9893.65YesYes199
30A:A:L283 A:A:Y287 12.53254.69NoYes077
31A:A:M247 A:A:Y287 29.1324.79NoYes067
32A:A:F307 A:A:M247 16.71389.95YesNo086
33A:A:C286 A:A:Y287 11.30085.38YesYes567
34A:A:L310 A:A:M247 12.83437.07NoNo046
35A:A:K345 R:R:L209 76.78514.23YesYes352
36R:R:L209 R:R:M215 76.892314.14YesNo027
37R:R:L203 R:R:M215 76.69497.07NoNo087
38R:R:L203 R:R:V117 38.22674.47NoNo088
39R:R:I199 R:R:V117 38.10547.68NoNo088
40R:R:I199 R:R:I222 37.98414.42NoYes087
41R:R:I222 R:R:R113 74.66285.01YesNo079
42R:R:F40 R:R:L54 15.31094.87YesNo478
43R:R:L203 R:R:T219 38.36994.42NoNo086
44R:R:T219 R:R:V200 38.24863.17NoNo065
45R:R:I222 R:R:V200 38.0063.07YesNo075
46R:R:R113 R:R:Y278 66.35328.23NoYes499
47B:B:L261 B:B:L30 18.8975.54NoYes055
48B:B:L261 G:G:V30 18.69924.47NoNo058
49B:B:Q259 G:G:V30 18.50115.73NoNo068
50B:B:Q259 B:B:R22 18.10453.5NoYes066
51B:B:D258 B:B:R22 11.849413.1YesYes276
52B:B:L30 B:B:M262 20.40047.07YesYes054
53B:B:E138 B:B:I120 10.36755.47NoNo066
54B:B:D118 B:B:I120 11.02824.2NoNo096
55B:B:D118 B:B:S97 11.252411.78NoNo098
56B:B:G162 B:B:Y145 45.844610.14NoYes198
57B:B:G162 B:B:S161 45.65813.71NoNo199
58B:B:H142 B:B:S161 43.925716.74YesNo199
59B:B:H142 B:B:T159 30.88776.85YesYes199
60B:B:C149 B:B:T159 23.05923.38YesYes189
61B:B:C149 B:B:T102 23.01836.76YesNo088
62B:B:C148 B:B:T102 22.72963.38NoNo068
63B:B:F151 B:B:I157 11.820611.3YesYes197
64B:B:H142 B:B:W169 12.82135.29YesYes198
65B:B:C148 B:B:S160 10.33453.44NoYes666
66B:B:C148 B:B:L190 12.10614.76NoNo665
67B:B:L190 B:B:V158 11.82445.96NoYes055
68B:B:D290 B:B:R314 33.643522.63YesYes168
69B:B:C271 B:B:D290 33.43547.78NoYes156
70B:B:C271 B:B:Y289 32.48454.03NoYes157
71B:B:M262 B:B:Y264 21.213711.97YesYes045
72B:B:W297 B:B:Y289 25.49898.68YesYes187
73R:R:D274 R:R:Y278 51.24575.75YesYes499
74R:R:D274 R:R:N270 45.42134.04YesNo099
75R:R:N270 R:R:Y233 44.03035.81NoYes099
76R:R:R99 R:R:Y233 17.357712.35NoYes089
77R:R:F181 R:R:R99 16.288211.76YesNo058
78R:R:T267 R:R:Y233 20.33237.49NoYes089
79R:R:T267 R:R:Y268 20.04034.99NoYes087
80R:R:L95 R:R:Y268 17.71313.52NoYes067
81R:R:L95 R:R:R71 16.27843.64NoYes066
82B:B:S97 B:B:W99 11.4793.71NoYes089
83A:A:F223 A:A:L39 32.12316.09YesYes199
84B:B:W297 B:B:Y264 25.30235.79YesYes185
85A:A:R208 A:A:W211 29.96046YesYes199
86A:A:W258 B:B:R314 38.79046YesYes158
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8Z8B
Class A
SubFamily Alicarboxylic acid
Type Hydroxycarboxylic Acid
SubType HCA1
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.65
Date 2025-10-29
D.O.I. To be published
Net Summary
Imin 2.98
Number of Linked Nodes 851
Number of Links 1077
Number of Hubs 196
Number of Links mediated by Hubs 688
Number of Communities 25
Number of Nodes involved in Communities 284
Number of Links involved in Communities 436
Path Summary
Number Of Nodes in MetaPath 87
Number Of Links MetaPath 86
Number of Shortest Paths 1828167
Length Of Smallest Path 3
Average Path Length 29.3184
Length of Longest Path 63
Minimum Path Strength 1.165
Average Path Strength 6.48905
Maximum Path Strength 26.08
Minimum Path Correlation 0.7
Average Path Correlation 0.986447
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.7027
Average % Of Corr. Nodes 43.9098
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 54.8923
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • cell communication   • negative regulation of catabolic process   • lipid catabolic process   • catabolic process   • regulation of lipid metabolic process   • negative regulation of metabolic process   • negative regulation of biological process   • primary metabolic process   • regulation of catabolic process   • regulation of lipid catabolic process   • regulation of primary metabolic process   • negative regulation of cellular process   • metabolic process   • regulation of metabolic process   • negative regulation of lipid metabolic process   • negative regulation of lipid catabolic process   • lipid metabolic process   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • neuropeptide signaling pathway   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • cell surface receptor signaling pathway   • response to cytokine   • response to chemokine   • cytokine-mediated signaling pathway   • cellular response to chemokine   • chemokine-mediated signaling pathway   • response to peptide   • cellular response to cytokine stimulus   • multicellular organismal process   • system process   • relaxation of smooth muscle   • regulation of system process   • regulation of muscle system process   • muscle system process   • relaxation of muscle   • positive regulation of relaxation of smooth muscle   • positive regulation of relaxation of muscle   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • regulation of relaxation of smooth muscle   • regulation of relaxation of muscle   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of transport   • localization   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • signal release   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • cell projection   • sperm principal piece   • cilium   • 9+2 motile cilium   • sperm flagellum   • motile cilium   • plasma membrane bounded cell projection   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • ciliary basal body   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to hormone stimulus   • synapse   • cell junction   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium
Gene OntologyCellular Component
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>8Z8B_Chain_A
CTLSAEDKA AVERSKMID RNLREDGEK AAREVKLLL LGAGESGKT 
IVKQMKTGI VETHFTFKD LHFKMFDVG QRSERKKWI HCFEGVTAI 
IFCVALSDY DLVLAEDEE MNRMHSMKL FDSICNNKW FTDTSIILF 
LNKKDLFEE KIKKSPLTI CYPEYAGSN TYEEAAAYI QCQFEDLNK 
RKDTKEIYT HFTCTDTKN VQFVFDAVT DVIIKNNLK DCGLFNAAS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8Z8B_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8Z8B_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ9BXC0
Sequence
>8Z8B_Chain_R
CCRIEGDTI SQVMPPLLI VAFVLGALG NGVALCGFC FHMKTWKPS 
TVYLFNLAV ADFLLMICL PFRTDYYLR RRHWAFGDI PCRVGLFTL 
AMNRAGSIV FLTVVAADR YFKVVHPHH AVNTISTRV AAGIVCTLW 
ALVILGTVY LLLENHLCV QETAVSCES FIMESANGW HDIMFQLEF 
FMPLGIILF CSFKIVWSL RRRQQLARQ ARMKKATRF IMVVAIVFI 
TCYLPSVSA RLYFLWTVP SSACDPSVH GALHITLSF TYMNSMLDP 
LVYYFSSPS FP


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9IZDAAlicarboxylic acidHydroxycarboxylic AcidHCA1Homo sapiensCHBA-Gi1/β1/γ23.162025-04-02doi.org/10.1371/journal.pbio.3003126
9IZD (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA1Homo sapiensCHBA-3.162025-04-02doi.org/10.1371/journal.pbio.3003126
9J8ZAAlicarboxylic acidHydroxycarboxylic AcidHCA1Homo sapiens--Gi1/β1/γ23.362025-04-02doi.org/10.1371/journal.pbio.3003126
9J8Z (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA1Homo sapiens--3.362025-04-02doi.org/10.1371/journal.pbio.3003126
8Z8AAAlicarboxylic acidHydroxycarboxylic AcidHCA1Homo sapiensLactate-Gi1/β1/γ22.822025-10-29To be published
8Z8A (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA1Homo sapiensLactate-2.822025-10-29To be published
8Z8B (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA1Homo sapiens--2.652025-10-29To be published
8Z87AAlicarboxylic acidHydroxycarboxylic AcidHCA1Homo sapiensCHBA-Gi1/β1/γ22.732025-11-05To be published
8Z87 (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA1Homo sapiensCHBA-2.732025-11-05To be published
9KT9AAlicarboxylic acidHydroxycarboxylic AcidHCA1Homo sapiens3,5-DHBA-Gi1/β1/γ22.72025-12-1010.1021/acs.jmedchem.4c02567
9KT9 (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA1Homo sapiens3,5-DHBA-2.72025-12-1010.1021/acs.jmedchem.4c02567




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