psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R71	13.52	Yes	No	1	0	6
2	L:L:?1	R:R:Y75	4.35	Yes	Yes	1	0	5
3	L:L:?1	R:R:L95	7.7	Yes	Yes	1	0	6
4	L:L:?1	R:R:R99	10.14	Yes	Yes	1	0	8
5	L:L:?1	R:R:S167	8.36	Yes	No	1	0	4
6	L:L:?1	R:R:F168	14.68	Yes	Yes	1	0	4
7	L:L:?1	R:R:H261	7.15	Yes	Yes	1	0	5
8	L:L:?1	R:R:L264	12.84	Yes	No	1	0	6
9	L:L:?1	R:R:Y268	9.78	Yes	Yes	1	0	7
10	R:R:C157	R:R:C6	5.46	No	No	0	3	6
11	R:R:C6	R:R:Q159	6.1	No	No	0	6	3
12	R:R:C7	R:R:E171	7.6	No	No	0	6	1
13	R:R:C252	R:R:C7	7.28	No	No	0	7	6
14	R:R:Q159	R:R:R8	5.84	No	No	0	3	2
15	R:R:E160	R:R:R8	9.3	No	No	0	2	2
16	R:R:I9	R:R:R79	3.76	No	Yes	1	4	5
17	R:R:H257	R:R:I9	10.61	Yes	No	1	4	4
18	R:R:I14	R:R:M18	7.29	Yes	Yes	0	4	5
19	R:R:H257	R:R:I14	5.3	Yes	Yes	1	4	4
20	R:R:G258	R:R:I14	3.53	No	Yes	1	1	4
21	R:R:M18	R:R:Y75	16.76	Yes	Yes	0	5	5
22	R:R:P19	R:R:P20	5.84	No	No	0	6	4
23	R:R:L76	R:R:P19	6.57	No	No	0	3	6
24	R:R:L22	R:R:T72	8.84	No	No	0	7	7
25	R:R:F26	R:R:P69	10.11	No	No	0	7	9
26	R:R:L28	R:R:M272	5.65	No	Yes	0	5	8
27	R:R:G29	R:R:M65	3.49	No	No	0	8	6
28	R:R:G29	R:R:M272	3.49	No	Yes	0	8	8
29	R:R:G32	R:R:P275	4.06	No	No	0	7	9
30	R:R:D61	R:R:N33	6.73	Yes	No	0	9	9
31	R:R:F62	R:R:N33	6.04	Yes	No	0	7	9
32	R:R:N33	R:R:P275	13.03	No	No	0	9	9
33	R:R:F62	R:R:G34	4.52	Yes	No	0	7	4
34	R:R:F280	R:R:V35	5.24	No	No	0	7	5
35	R:R:A36	R:R:Y279	5.34	No	Yes	0	8	7
36	R:R:F55	R:R:L37	6.09	Yes	No	0	6	8
37	R:R:F62	R:R:L37	3.65	Yes	No	0	7	8
38	R:R:G39	R:R:H43	6.35	No	No	0	8	5
39	R:R:F40	R:R:W47	4.01	Yes	Yes	3	7	6
40	R:R:F40	R:R:T51	3.89	Yes	No	3	7	8
41	R:R:F40	R:R:L54	4.87	Yes	No	0	7	8
42	R:R:F40	R:R:F55	6.43	Yes	Yes	3	7	6
43	R:R:F40	R:R:Y279	11.35	Yes	Yes	3	7	7
44	R:R:F285	R:R:F40	5.36	No	Yes	3	9	7
45	R:R:C41	R:R:F42	4.19	No	No	0	4	4
46	R:R:C41	R:R:F55	4.19	No	Yes	0	4	6
47	R:R:M44	R:R:W47	3.49	No	Yes	3	6	6
48	R:R:M44	R:R:T51	4.52	No	No	3	6	8
49	R:R:M44	R:R:P286	3.35	No	No	0	6	8
50	R:R:T51	R:R:W47	12.13	No	Yes	3	8	6
51	R:R:F55	R:R:W47	15.03	Yes	Yes	3	6	6
52	R:R:P49	R:R:Y53	4.17	Yes	Yes	5	7	7
53	R:R:I127	R:R:P49	5.08	No	Yes	0	7	7
54	R:R:A132	R:R:P49	3.74	No	Yes	5	8	7
55	R:R:D112	R:R:S50	4.42	No	No	0	8	7
56	R:R:A132	R:R:V52	5.09	No	No	0	8	7
57	R:R:V136	R:R:V52	4.81	Yes	No	0	7	7
58	R:R:V108	R:R:Y53	8.83	No	Yes	0	6	7
59	R:R:D112	R:R:Y53	9.2	No	Yes	0	8	7
60	R:R:A132	R:R:Y53	4	No	Yes	5	8	7
61	R:R:L54	R:R:V109	4.47	No	No	0	8	9
62	R:R:L54	R:R:Y278	4.69	No	Yes	0	8	9
63	R:R:F55	R:R:V59	3.93	Yes	No	0	6	5
64	R:R:F105	R:R:N56	10.87	No	No	6	7	9
65	R:R:N56	R:R:V136	11.82	No	Yes	0	9	7
66	R:R:N56	R:R:W140	6.78	No	No	6	9	9
67	R:R:D61	R:R:L57	6.79	Yes	No	2	9	9
68	R:R:L106	R:R:L57	5.54	No	No	2	8	9
69	R:R:L57	R:R:Y278	7.03	No	Yes	2	9	9
70	R:R:D61	R:R:S102	5.89	Yes	No	2	9	9
71	R:R:D61	R:R:S271	8.83	Yes	No	2	9	9
72	R:R:D274	R:R:D61	11.98	Yes	Yes	2	9	9
73	R:R:F62	R:R:I66	6.28	Yes	No	0	7	5
74	R:R:L63	R:R:N98	8.24	No	No	0	7	8
75	R:R:L64	R:R:M65	4.24	No	No	0	7	6
76	R:R:L64	R:R:L95	5.54	No	Yes	0	7	6
77	R:R:L64	R:R:N98	5.49	No	No	0	7	8
78	R:R:L68	R:R:M65	4.24	No	No	0	8	6
79	R:R:C67	R:R:T94	5.07	No	No	0	6	4
80	R:R:L68	R:R:Y268	11.72	No	Yes	0	8	7
81	R:R:R71	R:R:Y74	16.46	No	Yes	1	6	5
82	R:R:R71	R:R:Y75	11.32	No	Yes	1	6	5
83	R:R:D73	R:R:F83	5.97	No	No	0	3	7
84	R:R:Y74	R:R:Y75	7.94	Yes	Yes	1	5	5
85	R:R:R79	R:R:Y74	8.23	Yes	Yes	1	5	5
86	R:R:W81	R:R:Y74	7.72	Yes	Yes	1	8	5
87	R:R:E166	R:R:Y74	6.73	No	Yes	0	4	5
88	R:R:R79	R:R:Y75	4.12	Yes	Yes	1	5	5
89	R:R:H261	R:R:Y75	9.8	Yes	Yes	1	5	5
90	R:R:H257	R:R:R79	10.16	Yes	Yes	1	4	5
91	R:R:H80	R:R:V163	4.15	No	No	0	5	5
92	R:R:F83	R:R:W81	14.03	No	Yes	0	7	8
93	R:R:C88	R:R:W81	5.22	No	Yes	1	9	8
94	R:R:L156	R:R:W81	5.69	Yes	Yes	1	5	8
95	R:R:C165	R:R:W81	7.84	No	Yes	1	9	8
96	R:R:G84	R:R:P87	4.06	No	No	0	8	6
97	R:R:D85	R:R:R89	16.68	No	No	1	3	6
98	R:R:D85	R:R:N154	9.42	No	No	1	3	4
99	R:R:D85	R:R:L156	5.43	No	Yes	1	3	5
100	R:R:I86	R:R:P87	3.39	No	No	0	3	6
101	R:R:C88	R:R:L156	6.35	No	Yes	1	9	5
102	R:R:C165	R:R:C88	7.28	No	No	1	9	9
103	R:R:N154	R:R:R89	7.23	No	No	1	4	6
104	R:R:H155	R:R:L92	6.43	No	No	0	4	6
105	R:R:C165	R:R:L92	4.76	No	No	0	9	6
106	R:R:F93	R:R:M97	11.2	No	Yes	1	5	6
107	R:R:F93	R:R:T147	6.49	No	Yes	1	5	6
108	R:R:F93	R:R:L151	10.96	No	No	0	5	5
109	R:R:L95	R:R:Y268	4.69	Yes	Yes	1	6	7
110	R:R:I144	R:R:M97	7.29	No	Yes	0	4	6
111	R:R:M97	R:R:T147	4.52	Yes	Yes	1	6	6
112	R:R:E184	R:R:R99	10.47	No	Yes	0	5	8
113	R:R:R99	R:R:Y233	4.12	Yes	Yes	1	8	9
114	R:R:R99	R:R:T267	5.17	Yes	No	1	8	8
115	R:R:G101	R:R:V143	3.68	No	No	0	7	7
116	R:R:S102	R:R:S271	3.26	No	No	2	9	9
117	R:R:E184	R:R:I103	6.83	No	Yes	0	5	8
118	R:R:I103	R:R:P188	3.39	Yes	No	0	8	9
119	R:R:F229	R:R:I103	5.02	Yes	Yes	1	9	8
120	R:R:I103	R:R:Y233	10.88	Yes	Yes	1	8	9
121	R:R:L139	R:R:V104	5.96	Yes	No	0	7	6
122	R:R:F105	R:R:L139	3.65	No	Yes	0	7	7
123	R:R:F105	R:R:W140	14.03	No	No	6	7	9
124	R:R:D274	R:R:L106	8.14	Yes	No	2	9	8
125	R:R:L106	R:R:Y278	5.86	No	Yes	2	8	9
126	R:R:P188	R:R:T107	6.99	No	No	0	9	7
127	R:R:I191	R:R:T107	4.56	No	No	0	6	7
128	R:R:R113	R:R:V109	7.85	No	No	0	9	9
129	R:R:D112	R:R:K116	15.21	No	No	0	8	8
130	R:R:I222	R:R:R113	5.01	No	No	0	7	9
131	R:R:R113	R:R:Y278	6.17	No	Yes	0	9	9
132	R:R:F115	R:R:Y114	7.22	No	Yes	4	5	9
133	R:R:V118	R:R:Y114	12.62	Yes	Yes	4	7	9
134	R:R:H119	R:R:Y114	8.71	Yes	Yes	4	7	9
135	R:R:F194	R:R:Y114	9.28	No	Yes	4	5	9
136	R:R:C195	R:R:Y114	8.06	No	Yes	0	8	9
137	R:R:K198	R:R:Y114	5.97	No	Yes	4	4	9
138	R:R:F115	R:R:H119	4.53	No	Yes	4	5	7
139	R:R:F115	R:R:V124	5.24	No	No	0	5	5
140	R:R:K116	R:R:N125	8.39	No	No	0	8	3
141	R:R:I199	R:R:V117	9.22	No	No	0	8	8
142	R:R:L203	R:R:V117	4.47	No	No	0	8	8
143	R:R:H119	R:R:V118	6.92	Yes	Yes	4	7	7
144	R:R:S202	R:R:V118	6.46	No	Yes	0	5	7
145	R:R:H119	R:R:H122	3.58	Yes	No	0	7	4
146	R:R:H121	R:R:P120	7.63	No	No	0	6	7
147	R:R:H122	R:R:V124	5.54	No	No	0	4	5
148	R:R:I127	R:R:V131	9.22	No	No	0	7	4
149	R:R:R130	R:R:T129	10.35	No	No	0	4	3
150	R:R:L150	R:R:Y149	11.72	No	Yes	0	5	7
151	R:R:W176	R:R:Y149	10.61	No	Yes	1	5	7
152	R:R:H177	R:R:Y149	8.71	Yes	Yes	1	5	7
153	R:R:M180	R:R:Y149	5.99	No	Yes	1	4	7
154	R:R:H155	R:R:L150	6.43	No	No	0	4	5
155	R:R:E153	R:R:H155	6.15	No	No	0	4	4
156	R:R:L156	R:R:N154	5.49	Yes	No	1	5	4
157	R:R:L156	R:R:V163	5.96	Yes	No	0	5	5
158	R:R:C157	R:R:S164	3.44	No	No	0	3	4
159	R:R:E166	R:R:H261	11.08	No	Yes	0	4	5
160	R:R:F168	R:R:S167	3.96	Yes	No	1	4	4
161	R:R:H177	R:R:S167	12.55	Yes	No	1	5	4
162	R:R:F168	R:R:H177	24.89	Yes	Yes	1	4	5
163	R:R:F168	R:R:F181	15	Yes	Yes	1	4	5
164	R:R:F168	R:R:R240	8.55	Yes	Yes	1	4	5
165	R:R:F168	R:R:L264	6.09	Yes	No	1	4	6
166	R:R:E171	R:R:I169	5.47	No	No	0	1	4
167	R:R:I169	R:R:N174	8.5	No	No	0	4	3
168	R:R:F243	R:R:M170	6.22	No	No	0	4	3
169	R:R:H257	R:R:M170	9.19	Yes	No	0	4	3
170	R:R:H177	R:R:N174	8.93	Yes	No	0	5	3
171	R:R:I179	R:R:W176	8.22	No	No	0	4	5
172	R:R:M180	R:R:W176	16.29	No	No	1	4	5
173	R:R:D178	R:R:H177	3.78	Yes	Yes	1	4	5
174	R:R:D178	R:R:R240	13.1	Yes	Yes	1	4	5
175	R:R:D178	R:R:L244	10.86	Yes	No	1	4	5
176	R:R:F181	R:R:Q182	5.86	Yes	Yes	1	5	5
177	R:R:E184	R:R:F181	4.66	No	Yes	0	5	5
178	R:R:F181	R:R:S236	5.28	Yes	No	0	5	6
179	R:R:F181	R:R:R240	4.28	Yes	Yes	1	5	5
180	R:R:F181	R:R:L264	3.65	Yes	No	1	5	6
181	R:R:F186	R:R:Q182	5.86	No	Yes	1	5	5
182	R:R:Q182	R:R:V237	5.73	Yes	No	1	5	8
183	R:R:L241	R:R:Q182	5.32	No	Yes	0	5	5
184	R:R:L183	R:R:M187	5.65	No	No	0	4	5
185	R:R:F185	R:R:F186	6.43	Yes	No	1	8	5
186	R:R:F185	R:R:L189	7.31	Yes	Yes	1	8	6
187	R:R:F185	R:R:F229	6.43	Yes	Yes	1	8	9
188	R:R:F185	R:R:L234	6.09	Yes	Yes	0	8	5
189	R:R:F185	R:R:V237	6.55	Yes	No	1	8	8
190	R:R:F186	R:R:V237	3.93	No	No	1	5	8
191	R:R:M187	R:R:P188	3.35	No	No	0	5	9
192	R:R:L189	R:R:L193	4.15	Yes	No	0	6	4
193	R:R:F229	R:R:L189	3.65	Yes	Yes	1	9	6
194	R:R:F194	R:R:K198	11.17	No	No	4	5	4
195	R:R:F197	R:R:K198	4.96	No	No	0	1	4
196	R:R:I199	R:R:I222	4.42	No	No	0	8	7
197	R:R:R204	R:R:V200	5.23	No	No	7	4	5
198	R:R:T219	R:R:V200	4.76	No	No	7	6	5
199	R:R:S202	R:R:W201	3.71	No	No	0	5	3
200	R:R:R205	R:R:W201	11	No	No	0	4	3
201	R:R:L203	R:R:T219	5.9	No	No	0	8	6
202	R:R:R204	R:R:T219	7.76	No	No	7	4	6
203	R:R:Q208	R:R:R211	4.67	No	No	0	3	3
204	R:R:L209	R:R:Q212	5.32	No	No	8	2	3
205	R:R:L209	R:R:M215	9.9	No	No	8	2	7
206	R:R:M215	R:R:Q212	4.08	No	No	8	7	3
207	R:R:F221	R:R:K217	8.69	No	No	0	8	7
208	R:R:K217	R:R:P283	5.02	No	No	0	7	5
209	R:R:F221	R:R:V224	3.93	No	No	0	8	6
210	R:R:F221	R:R:S281	11.89	No	No	0	8	7
211	R:R:V225	R:R:Y278	8.83	No	Yes	0	8	9
212	R:R:F229	R:R:Y233	11.35	Yes	Yes	1	9	9
213	R:R:C232	R:R:N270	7.87	No	Yes	0	9	9
214	R:R:T267	R:R:Y233	7.49	No	Yes	1	8	9
215	R:R:N270	R:R:Y233	13.96	Yes	Yes	0	9	9
216	R:R:L234	R:R:P235	3.28	Yes	No	0	5	9
217	R:R:P235	R:R:T263	3.5	No	No	0	9	7
218	R:R:F266	R:R:P235	5.78	No	No	0	7	9
219	R:R:F243	R:R:R240	13.9	No	Yes	0	4	5
220	R:R:L244	R:R:R240	4.86	No	Yes	1	5	5
221	R:R:L260	R:R:R240	4.86	No	Yes	0	4	5
222	R:R:T246	R:R:Y242	4.99	No	No	0	3	4
223	R:R:S250	R:R:T246	6.4	No	No	0	2	3
224	R:R:P248	R:R:V247	3.53	No	No	0	1	3
225	R:R:D253	R:R:P254	9.66	No	No	0	2	2
226	R:R:D253	R:R:V256	10.22	No	No	0	2	3
227	R:R:G258	R:R:H257	4.77	No	Yes	1	1	4
228	R:R:H257	R:R:H261	19.11	Yes	Yes	1	4	5
229	R:R:T267	R:R:Y268	6.24	No	Yes	1	8	7
230	R:R:M269	R:R:M272	4.33	No	Yes	0	4	8
231	R:R:D274	R:R:N270	9.42	Yes	Yes	0	9	9
232	R:R:L273	R:R:M272	4.24	No	Yes	0	7	8
233	R:R:D274	R:R:Y278	5.75	Yes	Yes	2	9	9
234	R:R:F280	R:R:L276	3.65	No	No	0	7	6
235	R:R:V277	R:R:Y278	3.79	No	Yes	0	8	9
236	R:R:F285	R:R:Y279	13.41	No	Yes	3	9	7
237	R:R:P283	R:R:S282	3.56	No	No	0	5	8
238	R:R:S282	R:R:S284	3.26	No	No	0	8	6
239	R:R:F285	R:R:S282	13.21	No	No	0	9	8
240	R:R:S250	R:R:V256	3.23	No	No	0	2	3
241	R:R:A25	R:R:M269	3.22	No	No	0	7	4
242	R:R:V104	R:R:V143	3.21	No	No	0	6	7
243	R:R:V117	R:R:V118	3.21	No	Yes	0	8	7
244	R:R:V158	R:R:V163	3.21	No	No	0	1	5
245	R:R:C67	R:R:L95	3.17	No	Yes	0	6	6
246	R:R:A58	R:R:L37	3.15	No	No	0	8	8
247	R:R:I222	R:R:S196	3.1	No	No	0	7	8
248	R:R:A173	R:R:D178	3.09	No	Yes	0	3	4
249	R:R:I262	R:R:V17	3.07	No	No	0	5	5
250	R:R:M269	R:R:S265	3.07	No	No	0	4	5
251	R:R:I14	R:R:T13	3.04	Yes	No	0	4	3
252	R:R:I23	R:R:T72	3.04	No	No	0	5	7
253	R:R:M97	R:R:V143	3.04	Yes	No	0	6	7
254	R:R:I192	R:R:T107	3.04	No	No	0	8	7
255	R:R:M170	R:R:V256	3.04	No	No	0	3	3
256	R:R:M223	R:R:V200	3.04	No	No	0	5	5
257	R:R:F280	R:R:G32	3.01	No	No	0	7	7
258	R:R:M180	R:R:T147	3.01	No	Yes	1	4	6
259	R:R:L21	R:R:S265	3	No	No	0	4	5
260	R:R:L234	R:R:S238	3	Yes	No	0	5	6
261	R:R:N270	R:R:V228	2.96	Yes	No	0	9	7
262	R:R:L76	R:R:T72	2.95	No	No	0	3	7
263	R:R:D253	R:R:S255	2.94	No	No	0	2	4
264	R:R:A82	R:R:H80	2.93	No	No	0	3	5
265	R:R:A123	R:R:H122	2.93	No	No	0	5	4
266	R:R:I262	R:R:M18	2.92	No	Yes	0	5	5
267	R:R:G39	R:R:Y279	2.9	No	Yes	0	8	7
268	R:R:F70	R:R:P69	2.89	No	No	0	6	9
269	R:R:I135	R:R:L139	2.85	No	Yes	0	6	7
270	R:R:I230	R:R:L189	2.85	No	Yes	0	6	6
271	R:R:I230	R:R:L234	2.85	No	Yes	0	6	5
272	R:R:L22	R:R:M18	2.83	No	Yes	0	7	5
273	R:R:C38	R:R:F42	2.79	No	No	0	4	4
274	R:R:A30	R:R:F26	2.77	No	No	0	5	7
275	R:R:F243	R:R:V247	2.62	No	No	0	4	3
276	R:R:A60	R:R:W140	2.59	No	No	0	8	9
277	R:R:S164	R:R:Y74	2.54	No	Yes	0	4	5
278	R:R:M223	R:R:R220	2.48	No	No	0	5	5
279	R:R:F26	R:R:L68	2.44	No	No	0	7	8
280	R:R:L209	R:R:R206	2.43	No	No	0	2	5
281	R:R:T246	R:R:W245	2.43	No	No	0	3	4
282	R:R:A100	R:R:G101	1.95	No	No	0	6	7
283	R:R:G11	R:R:T13	1.82	No	No	0	4	3
284	R:R:G91	R:R:T94	1.82	No	No	0	6	4
285	R:R:A110	R:R:C195	1.81	No	No	0	9	8
286	R:R:P49	R:R:T129	1.75	Yes	No	0	7	3
287	R:R:G32	R:R:L31	1.71	No	No	0	7	4
288	R:R:C137	R:R:V136	1.71	No	Yes	0	5	7
289	R:R:G190	R:R:L189	1.71	No	Yes	0	3	6
290	R:R:A226	R:R:S196	1.71	No	No	0	7	8
291	R:R:A133	R:R:V136	1.7	No	Yes	0	4	7
292	R:R:C232	R:R:T231	1.69	No	No	0	9	6
293	R:R:A96	R:R:T147	1.68	No	Yes	0	5	6
294	R:R:A239	R:R:T263	1.68	No	No	0	4	7
295	R:R:K48	R:R:P49	1.67	No	Yes	0	7	7
296	R:R:S172	R:R:V247	1.62	No	No	0	1	3
297	R:R:S128	R:R:T129	1.6	No	No	0	6	3
298	R:R:T94	R:R:V90	1.59	No	No	0	4	5
299	R:R:I86	R:R:V90	1.54	No	No	0	3	5
300	R:R:H119	R:R:P120	1.53	Yes	No	0	7	7
301	R:R:L28	R:R:V24	1.49	No	No	0	5	5
302	R:R:L28	R:R:V27	1.49	No	No	0	5	6
303	R:R:L151	R:R:V148	1.49	No	No	0	5	3
304	R:R:L152	R:R:V148	1.49	No	No	0	3	3
305	R:R:L142	R:R:T138	1.47	No	No	0	4	3
306	R:R:A162	R:R:H80	1.46	No	No	0	3	5
307	R:R:L203	R:R:M215	1.41	No	No	0	8	7
308	R:R:A82	R:R:R77	1.38	No	No	0	3	4
309	R:R:L139	R:R:L142	1.38	Yes	No	0	7	4
310	R:R:K216	R:R:R220	1.24	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.83556	9	1	0
2	R:R:I14	4.79	4	1	4
3	R:R:M18	7.45	4	0	5
4	R:R:F40	5.985	6	3	7
5	R:R:W47	8.665	4	3	6
6	R:R:P49	3.282	5	5	7
7	R:R:Y53	6.55	4	5	7
8	R:R:F55	7.134	5	3	6
9	R:R:D61	8.044	5	2	9
10	R:R:F62	5.1225	4	0	7
11	R:R:Y74	8.27	6	1	5
12	R:R:Y75	9.04833	6	1	5
13	R:R:R79	6.5675	4	1	5
14	R:R:W81	8.1	5	1	8
15	R:R:L95	5.275	4	1	6
16	R:R:M97	6.5125	4	1	6
17	R:R:R99	7.475	4	1	8
18	R:R:I103	6.53	4	1	8
19	R:R:Y114	8.64333	6	4	9
20	R:R:V118	7.3025	4	4	7
21	R:R:H119	5.054	5	4	7
22	R:R:V136	5.01	4	0	7
23	R:R:L139	3.46	4	0	7
24	R:R:T147	3.925	4	1	6
25	R:R:Y149	9.2575	4	1	7
26	R:R:L156	5.784	5	1	5
27	R:R:F168	12.195	6	1	4
28	R:R:H177	11.772	5	1	5
29	R:R:D178	7.7075	4	1	4
30	R:R:F181	6.455	6	1	5
31	R:R:Q182	5.6925	4	1	5
32	R:R:F185	6.562	5	1	8
33	R:R:L189	3.934	5	1	6
34	R:R:F229	6.6125	4	1	9
35	R:R:Y233	9.56	5	1	9
36	R:R:L234	3.805	4	0	5
37	R:R:R240	8.25833	6	1	5
38	R:R:H257	9.85667	6	1	4
39	R:R:H261	11.785	4	1	5
40	R:R:Y268	8.1075	4	1	7
41	R:R:N270	8.5525	4	0	9
42	R:R:M272	4.4275	4	0	8
43	R:R:D274	8.8225	4	2	9
44	R:R:Y278	6.01714	7	2	9
45	R:R:Y279	8.25	4	3	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R71	20.8182	13.52	Yes	No	1	0	6
2	R:R:R71	R:R:Y74	19.9437	16.46	No	Yes	1	6	5
3	R:R:S164	R:R:Y74	14.0026	2.54	No	Yes	0	4	5
4	R:R:C157	R:R:S164	11.687	3.44	No	No	0	3	4
5	L:L:?1	R:R:Y75	35.5639	4.35	Yes	Yes	1	0	5
6	R:R:Y74	R:R:Y75	21.1935	7.94	Yes	Yes	1	5	5
7	L:L:?1	R:R:S167	36.4571	8.36	Yes	No	1	0	4
8	R:R:H177	R:R:S167	35.8003	12.55	Yes	No	1	5	4
9	R:R:H177	R:R:N174	10.2045	8.93	Yes	No	0	5	3
10	L:L:?1	R:R:F168	44.3685	14.68	Yes	Yes	1	0	4
11	R:R:F168	R:R:H177	47.1195	24.89	Yes	Yes	1	4	5
12	L:L:?1	R:R:H261	12.903	7.15	Yes	Yes	1	0	5
13	R:R:H257	R:R:H261	11.1691	19.11	Yes	Yes	1	4	5
14	R:R:M18	R:R:Y75	14.1227	16.76	Yes	Yes	0	5	5
15	L:L:?1	R:R:Y268	14.4005	9.78	Yes	Yes	1	0	7
16	R:R:L68	R:R:Y268	20.0225	11.72	No	Yes	0	8	7
17	L:L:?1	R:R:L95	22.4658	7.7	Yes	Yes	1	0	6
18	R:R:L64	R:R:L95	14.1903	5.54	No	Yes	0	7	6
19	R:R:G29	R:R:M65	21.0171	3.49	No	No	0	8	6
20	R:R:G29	R:R:M272	18.9416	3.49	No	Yes	0	8	8
21	R:R:L68	R:R:M65	13.9238	4.24	No	No	0	8	6
22	L:L:?1	R:R:R99	84.59	10.14	Yes	Yes	1	0	8
23	R:R:R99	R:R:Y233	85.5433	4.12	Yes	Yes	1	8	9
24	R:R:N270	R:R:Y233	100	13.96	Yes	Yes	0	9	9
25	R:R:D274	R:R:N270	96.8775	9.42	Yes	Yes	0	9	9
26	R:R:D274	R:R:D61	20.3453	11.98	Yes	Yes	2	9	9
27	R:R:D61	R:R:N33	17.0276	6.73	Yes	No	0	9	9
28	R:R:D274	R:R:Y278	78.0897	5.75	Yes	Yes	2	9	9
29	R:R:L54	R:R:Y278	33.6649	4.69	No	Yes	0	8	9
30	R:R:F40	R:R:L54	34.9597	4.87	Yes	No	0	7	8
31	R:R:F285	R:R:F40	12.0585	5.36	No	Yes	3	9	7
32	R:R:H177	R:R:Y149	73.5635	8.71	Yes	Yes	1	5	7
33	R:R:M180	R:R:Y149	68.921	5.99	No	Yes	1	4	7
34	R:R:M180	R:R:T147	67.5812	3.01	No	Yes	1	4	6
35	R:R:M97	R:R:T147	57.1064	4.52	Yes	Yes	1	6	6
36	R:R:M97	R:R:V143	54.194	3.04	Yes	No	0	6	7
37	R:R:V104	R:R:V143	49.0448	3.21	No	No	0	6	7
38	R:R:L139	R:R:V104	47.3109	5.96	Yes	No	0	7	6
39	R:R:F105	R:R:L139	40.3115	3.65	No	Yes	0	7	7
40	R:R:F105	R:R:N56	34.8508	10.87	No	No	6	7	9
41	R:R:N56	R:R:V136	33.1957	11.82	No	Yes	0	9	7
42	R:R:V136	R:R:V52	27.7876	4.81	Yes	No	0	7	7
43	R:R:A132	R:R:V52	25.9711	5.09	No	No	0	8	7
44	R:R:A132	R:R:P49	13.0418	3.74	No	Yes	5	8	7
45	R:R:A132	R:R:Y53	11.0903	4	No	Yes	5	8	7
46	R:R:R113	R:R:Y278	50.486	6.17	No	Yes	0	9	9
47	R:R:C67	R:R:L95	12.2124	3.17	No	Yes	0	6	6
48	R:R:C67	R:R:T94	10.4898	5.07	No	No	0	6	4
49	R:R:W81	R:R:Y74	27.9039	7.72	Yes	Yes	1	8	5
50	R:R:L156	R:R:W81	20.2252	5.69	Yes	Yes	1	5	8
51	R:R:L156	R:R:V163	12.2237	5.96	Yes	No	0	5	5
52	R:R:T267	R:R:Y268	12.7716	6.24	No	Yes	1	8	7
53	R:R:E184	R:R:I103	10.5536	6.83	No	Yes	0	5	8
54	R:R:I103	R:R:Y233	10.2683	10.88	Yes	Yes	1	8	9
55	R:R:F229	R:R:Y233	13.6536	11.35	Yes	Yes	1	9	9
56	R:R:I222	R:R:R113	51.9384	5.01	No	No	0	7	9
57	R:R:I199	R:R:I222	48.054	4.42	No	No	0	8	7
58	R:R:I199	R:R:V117	46.7105	9.22	No	No	0	8	8
59	R:R:V117	R:R:V118	30.1107	3.21	No	Yes	0	8	7
60	R:R:V118	R:R:Y114	12.0811	12.62	Yes	Yes	4	7	9
61	R:R:H119	R:R:V118	12.2162	6.92	Yes	Yes	4	7	7
62	R:R:L203	R:R:V117	16.8512	4.47	No	No	0	8	8
63	R:R:F243	R:R:R240	12.6553	13.9	No	Yes	0	4	5
64	R:R:F168	R:R:F181	11.049	15	Yes	Yes	1	4	5
65	R:R:F181	R:R:Q182	12.6665	5.86	Yes	Yes	1	5	5
66	R:R:F285	R:R:S282	10.7863	13.21	No	No	0	9	8
67	R:R:M170	R:R:V256	10.5348	3.04	No	No	0	3	3
68	R:R:T267	R:R:Y233	12.2124	7.49	No	Yes	1	8	9
69	R:R:E184	R:R:F181	12.7679	4.66	No	Yes	0	5	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:R71	13.52	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y75	4.35	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L95	7.7	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:R99	10.14	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:S167	8.36	1	Yes	No	0	4	0	1
L:L:?1	R:R:F168	14.68	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:H261	7.15	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L264	12.84	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y268	9.78	1	Yes	Yes	0	7	0	1
R:R:M18	R:R:Y75	16.76	0	Yes	Yes	5	5	2	1
R:R:L64	R:R:L95	5.54	0	No	Yes	7	6	2	1
R:R:L68	R:R:Y268	11.72	0	No	Yes	8	7	2	1
R:R:R71	R:R:Y74	16.46	1	No	Yes	6	5	1	2
R:R:R71	R:R:Y75	11.32	1	No	Yes	6	5	1	1
R:R:Y74	R:R:Y75	7.94	1	Yes	Yes	5	5	2	1
R:R:R79	R:R:Y74	8.23	1	Yes	Yes	5	5	2	2
R:R:E166	R:R:Y74	6.73	0	No	Yes	4	5	2	2
R:R:R79	R:R:Y75	4.12	1	Yes	Yes	5	5	2	1
R:R:H261	R:R:Y75	9.8	1	Yes	Yes	5	5	1	1
R:R:H257	R:R:R79	10.16	1	Yes	Yes	4	5	2	2
R:R:L95	R:R:Y268	4.69	1	Yes	Yes	6	7	1	1
R:R:E184	R:R:R99	10.47	0	No	Yes	5	8	2	1
R:R:R99	R:R:Y233	4.12	1	Yes	Yes	8	9	1	2
R:R:R99	R:R:T267	5.17	1	Yes	No	8	8	1	2
R:R:E166	R:R:H261	11.08	0	No	Yes	4	5	2	1
R:R:F168	R:R:S167	3.96	1	Yes	No	4	4	1	1
R:R:H177	R:R:S167	12.55	1	Yes	No	5	4	2	1
R:R:F168	R:R:H177	24.89	1	Yes	Yes	4	5	1	2
R:R:F168	R:R:F181	15	1	Yes	Yes	4	5	1	2
R:R:F168	R:R:R240	8.55	1	Yes	Yes	4	5	1	2
R:R:F168	R:R:L264	6.09	1	Yes	No	4	6	1	1
R:R:E184	R:R:F181	4.66	0	No	Yes	5	5	2	2
R:R:F181	R:R:R240	4.28	1	Yes	Yes	5	5	2	2
R:R:F181	R:R:L264	3.65	1	Yes	No	5	6	2	1
R:R:T267	R:R:Y233	7.49	1	No	Yes	8	9	2	2
R:R:H257	R:R:H261	19.11	1	Yes	Yes	4	5	2	1
R:R:T267	R:R:Y268	6.24	1	No	Yes	8	7	2	1
R:R:C67	R:R:L95	3.17	0	No	Yes	6	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8Z87_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.26
Number of Linked Nodes	258
Number of Links	310
Number of Hubs	45
Number of Links mediated by Hubs	167
Number of Communities	8
Number of Nodes involved in Communities	75
Number of Links involved in Communities	110

Path Summary
Number Of Nodes in MetaPath	70
Number Of Links MetaPath	69
Number of Shortest Paths	60566
Length Of Smallest Path	3
Average Path Length	13.6454
Length of Longest Path	34
Minimum Path Strength	1.425
Average Path Strength	7.30216
Maximum Path Strength	17.3875
Minimum Path Correlation	0.7
Average Path Correlation	0.925293
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	49.4494
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	52.6878
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • negative regulation of catabolic process • lipid catabolic process • catabolic process • negative regulation of metabolic process • regulation of catabolic process • regulation of lipid catabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9BXC0
Sequence	>8Z87_nogp_Chain_R C C R I E G D T I S Q V M P P L L I V A F V L G A L G N G V A L C G F C F H M K T W K P S T V Y L F N L A V A D F L L M I C L P F R T D Y Y L R R R H W A F G D I P C R V G L F T L A M N R A G S I V F L T V V A A D R Y F K V V H P H H A V N T I S T R V A A G I V C T L W A L V I L G T V Y L L L E N H L C V Q E T A V S C E S F I M E S A N G W H D I M F Q L E F F M P L G I I L F C S F K I V W S L R R R Q Q L A R Q A R M K K A T R F I M V V A I V F I T C Y L P S V S A R L Y F L W T V P S S A C D P S V H G A L H I T L S F T Y M N S M L D P L V Y Y F S S P S F P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9IZD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	CHBA	-	Gi1/β1/γ2	3.16	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9IZD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	CHBA	-		3.16	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9J8Z	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	-	-	Gi1/β1/γ2	3.36	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9J8Z (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	-	-		3.36	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	8Z8A	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	Lactate	-	Gi1/β1/γ2	2.82	2025-10-29	To be published
	8Z8A (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	Lactate	-		2.82	2025-10-29	To be published
	8Z8B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	-	-	Gi1/β1/γ2	2.65	2025-10-29	To be published
	8Z8B (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	-	-		2.65	2025-10-29	To be published
	8Z87	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	CHBA	-	Gi1/β1/γ2	2.73	2025-11-05	To be published
	8Z87 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	CHBA	-		2.73	2025-11-05	To be published
	9KT9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	3,5-DHBA	-	Gi1/β1/γ2	2.7	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	3,5-DHBA	-		2.7	2025-12-10	10.1021/acs.jmedchem.4c02567

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.