psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R71	9.74	Yes	Yes	0	0	6
2	L:L:?1	R:R:L95	8.32	Yes	No	0	0	6
3	L:L:?1	R:R:R99	4.87	Yes	No	0	0	8
4	L:L:?1	R:R:S167	6.02	Yes	No	0	0	4
5	L:L:?1	R:R:L264	4.16	Yes	No	0	0	6
6	L:L:?1	R:R:Y268	10.58	Yes	Yes	0	0	7
7	R:R:C157	R:R:C6	5.46	No	No	0	3	6
8	R:R:C252	R:R:C7	5.46	No	No	0	7	6
9	R:R:Q159	R:R:R8	10.51	No	No	0	3	2
10	R:R:E160	R:R:R8	5.82	No	No	0	2	2
11	R:R:C252	R:R:I9	4.91	No	No	0	7	4
12	R:R:H257	R:R:I9	7.95	Yes	No	0	4	4
13	R:R:D12	R:R:Q16	10.44	No	No	0	4	3
14	R:R:I14	R:R:M18	4.37	Yes	No	0	4	5
15	R:R:H261	R:R:I14	3.98	Yes	Yes	0	5	4
16	R:R:M18	R:R:Y75	19.16	No	Yes	0	5	5
17	R:R:M18	R:R:S265	4.6	No	No	0	5	5
18	R:R:P19	R:R:P20	5.84	No	No	0	6	4
19	R:R:L76	R:R:P19	6.57	No	No	0	3	6
20	R:R:L21	R:R:M269	4.24	No	No	0	4	4
21	R:R:L22	R:R:T72	8.84	No	No	0	7	7
22	R:R:F26	R:R:L68	3.65	No	No	0	7	8
23	R:R:F26	R:R:P69	10.11	No	No	0	7	9
24	R:R:L28	R:R:M272	8.48	No	No	0	5	8
25	R:R:G29	R:R:M65	3.49	No	No	0	8	6
26	R:R:G29	R:R:M272	3.49	No	No	0	8	8
27	R:R:G32	R:R:P275	4.06	No	No	0	7	9
28	R:R:D61	R:R:N33	8.08	Yes	No	0	9	9
29	R:R:F62	R:R:N33	3.62	Yes	No	0	7	9
30	R:R:N33	R:R:P275	13.03	No	No	0	9	9
31	R:R:F280	R:R:V35	5.24	No	No	0	7	5
32	R:R:A36	R:R:Y279	5.34	No	Yes	0	8	7
33	R:R:F55	R:R:L37	3.65	Yes	No	0	6	8
34	R:R:F62	R:R:L37	4.87	Yes	No	0	7	8
35	R:R:C38	R:R:F42	4.19	No	No	0	4	4
36	R:R:G39	R:R:Y279	4.35	No	Yes	0	8	7
37	R:R:F40	R:R:L54	4.87	Yes	No	1	7	8
38	R:R:F40	R:R:F55	6.43	Yes	Yes	0	7	6
39	R:R:F40	R:R:Y279	10.32	Yes	Yes	1	7	7
40	R:R:F285	R:R:F40	5.36	No	Yes	1	9	7
41	R:R:C41	R:R:F55	4.19	No	Yes	0	4	6
42	R:R:F42	R:R:H43	3.39	No	No	0	4	5
43	R:R:M44	R:R:T51	6.02	No	No	0	6	8
44	R:R:T51	R:R:W47	7.28	No	No	0	8	6
45	R:R:F55	R:R:W47	16.04	Yes	No	0	6	6
46	R:R:P49	R:R:Y53	4.17	Yes	Yes	6	7	7
47	R:R:I127	R:R:P49	6.77	No	Yes	0	7	7
48	R:R:P49	R:R:T129	3.5	Yes	No	0	7	3
49	R:R:A132	R:R:P49	3.74	No	Yes	6	8	7
50	R:R:A132	R:R:V52	5.09	No	No	0	8	7
51	R:R:V136	R:R:V52	4.81	Yes	No	0	7	7
52	R:R:V108	R:R:Y53	8.83	No	Yes	0	6	7
53	R:R:D112	R:R:Y53	9.2	No	Yes	0	8	7
54	R:R:A132	R:R:Y53	4	No	Yes	6	8	7
55	R:R:L54	R:R:V109	4.47	No	No	1	8	9
56	R:R:L54	R:R:Y278	4.69	No	Yes	1	8	9
57	R:R:F55	R:R:N56	3.62	Yes	Yes	0	6	9
58	R:R:F55	R:R:V59	7.87	Yes	No	0	6	5
59	R:R:F105	R:R:N56	10.87	No	Yes	5	7	9
60	R:R:N56	R:R:V136	10.35	Yes	Yes	5	9	7
61	R:R:N56	R:R:W140	3.39	Yes	Yes	5	9	9
62	R:R:D61	R:R:L57	5.43	Yes	Yes	1	9	9
63	R:R:L106	R:R:L57	5.54	No	Yes	1	8	9
64	R:R:D274	R:R:L57	5.43	Yes	Yes	1	9	9
65	R:R:L57	R:R:Y278	7.03	Yes	Yes	1	9	9
66	R:R:D61	R:R:S271	7.36	Yes	No	0	9	9
67	R:R:D274	R:R:D61	11.98	Yes	Yes	1	9	9
68	R:R:F62	R:R:I66	5.02	Yes	No	0	7	5
69	R:R:I66	R:R:L63	4.28	No	No	0	5	7
70	R:R:L63	R:R:N98	9.61	No	Yes	0	7	8
71	R:R:L64	R:R:N98	6.87	Yes	Yes	0	7	8
72	R:R:L64	R:R:Y268	7.03	Yes	Yes	0	7	7
73	R:R:L64	R:R:S271	7.51	Yes	No	0	7	9
74	R:R:C67	R:R:T94	6.76	No	No	0	6	4
75	R:R:L68	R:R:Y268	4.69	No	Yes	0	8	7
76	R:R:F70	R:R:F83	6.43	No	No	0	6	7
77	R:R:R71	R:R:Y74	8.23	Yes	Yes	2	6	5
78	R:R:R71	R:R:Y75	5.14	Yes	Yes	2	6	5
79	R:R:Y74	R:R:Y75	7.94	Yes	Yes	2	5	5
80	R:R:R79	R:R:Y74	9.26	Yes	Yes	2	5	5
81	R:R:W81	R:R:Y74	7.72	Yes	Yes	2	8	5
82	R:R:E166	R:R:Y74	6.73	Yes	Yes	2	4	5
83	R:R:R79	R:R:Y75	4.12	Yes	Yes	2	5	5
84	R:R:H261	R:R:Y75	9.8	Yes	Yes	0	5	5
85	R:R:E166	R:R:R79	6.98	Yes	Yes	2	4	5
86	R:R:H257	R:R:R79	7.9	Yes	Yes	0	4	5
87	R:R:F83	R:R:W81	8.02	No	Yes	0	7	8
88	R:R:C88	R:R:W81	5.22	No	Yes	2	9	8
89	R:R:L156	R:R:W81	3.42	No	Yes	2	5	8
90	R:R:C165	R:R:W81	11.75	No	Yes	2	9	8
91	R:R:D85	R:R:R89	17.87	No	No	0	3	6
92	R:R:D85	R:R:N154	10.77	No	No	0	3	4
93	R:R:I86	R:R:P87	3.39	No	No	0	3	6
94	R:R:I86	R:R:R89	3.76	No	No	0	3	6
95	R:R:C88	R:R:L156	6.35	No	No	2	9	5
96	R:R:C165	R:R:C88	7.28	No	No	2	9	9
97	R:R:H155	R:R:R89	3.39	No	No	0	4	6
98	R:R:H155	R:R:L92	7.71	No	No	0	4	6
99	R:R:C165	R:R:L92	4.76	No	No	0	9	6
100	R:R:L92	R:R:S167	4.5	No	No	0	6	4
101	R:R:F93	R:R:M97	11.2	No	Yes	7	5	6
102	R:R:F93	R:R:T147	5.19	No	No	7	5	6
103	R:R:F93	R:R:L151	15.83	No	No	0	5	5
104	R:R:N98	R:R:T94	4.39	Yes	No	0	8	4
105	R:R:M97	R:R:N98	4.21	Yes	Yes	0	6	8
106	R:R:I144	R:R:M97	4.37	No	Yes	0	4	6
107	R:R:M97	R:R:T147	9.03	Yes	No	7	6	6
108	R:R:E184	R:R:R99	4.65	No	No	0	5	8
109	R:R:G101	R:R:V143	3.68	No	No	0	7	7
110	R:R:E184	R:R:I103	5.47	No	No	0	5	8
111	R:R:I103	R:R:P188	3.39	No	No	0	8	9
112	R:R:I103	R:R:Y233	9.67	No	Yes	0	8	9
113	R:R:L139	R:R:V104	4.47	No	No	0	7	6
114	R:R:F105	R:R:V136	3.93	No	Yes	5	7	7
115	R:R:F105	R:R:W140	15.03	No	Yes	5	7	9
116	R:R:D274	R:R:L106	5.43	Yes	No	1	9	8
117	R:R:L106	R:R:Y278	3.52	No	Yes	1	8	9
118	R:R:P188	R:R:T107	5.25	No	No	0	9	7
119	R:R:I191	R:R:T107	4.56	No	No	0	6	7
120	R:R:R113	R:R:V109	6.54	No	No	1	9	9
121	R:R:V109	R:R:Y278	5.05	No	Yes	1	9	9
122	R:R:D112	R:R:K116	11.06	No	No	0	8	8
123	R:R:R113	R:R:Y278	8.23	No	Yes	1	9	9
124	R:R:F115	R:R:Y114	9.28	No	Yes	3	5	9
125	R:R:V118	R:R:Y114	12.62	Yes	Yes	3	7	9
126	R:R:H119	R:R:Y114	7.62	Yes	Yes	3	7	9
127	R:R:F194	R:R:Y114	6.19	No	Yes	3	5	9
128	R:R:C195	R:R:Y114	8.06	No	Yes	0	8	9
129	R:R:K198	R:R:Y114	5.97	No	Yes	3	4	9
130	R:R:F115	R:R:H119	4.53	No	Yes	3	5	7
131	R:R:K116	R:R:N125	13.99	No	No	0	8	3
132	R:R:I199	R:R:V117	7.68	No	No	0	8	8
133	R:R:H119	R:R:V118	5.54	Yes	Yes	3	7	7
134	R:R:S202	R:R:V118	4.85	No	Yes	0	5	7
135	R:R:H119	R:R:H122	4.78	Yes	No	0	7	4
136	R:R:H122	R:R:V124	5.54	No	No	0	4	5
137	R:R:I127	R:R:V131	6.14	No	No	0	7	4
138	R:R:R130	R:R:T129	3.88	No	No	0	4	3
139	R:R:L150	R:R:Y149	11.72	No	Yes	0	5	7
140	R:R:W176	R:R:Y149	4.82	No	Yes	8	5	7
141	R:R:M180	R:R:Y149	4.79	No	Yes	8	4	7
142	R:R:E153	R:R:H155	7.39	No	No	0	4	4
143	R:R:L156	R:R:V163	5.96	No	No	0	5	5
144	R:R:E166	R:R:S164	4.31	Yes	No	0	4	4
145	R:R:E166	R:R:I169	8.2	Yes	No	0	4	4
146	R:R:E166	R:R:H261	11.08	Yes	Yes	0	4	5
147	R:R:F168	R:R:S167	3.96	Yes	No	0	4	4
148	R:R:F168	R:R:H177	9.05	Yes	No	0	4	5
149	R:R:F168	R:R:F181	17.15	Yes	Yes	4	4	5
150	R:R:F168	R:R:R240	4.28	Yes	Yes	4	4	5
151	R:R:F168	R:R:L264	6.09	Yes	No	0	4	6
152	R:R:H257	R:R:I169	9.28	Yes	No	0	4	4
153	R:R:M170	R:R:N174	7.01	No	No	0	3	3
154	R:R:S172	R:R:V247	6.46	No	No	0	1	3
155	R:R:H177	R:R:N174	14.03	No	No	0	5	3
156	R:R:M180	R:R:W176	16.29	No	No	8	4	5
157	R:R:D178	R:R:R240	13.1	No	Yes	4	4	5
158	R:R:D178	R:R:L244	10.86	No	Yes	4	4	5
159	R:R:F181	R:R:Q182	5.86	Yes	Yes	0	5	5
160	R:R:E184	R:R:F181	3.5	No	Yes	0	5	5
161	R:R:F181	R:R:R240	4.28	Yes	Yes	4	5	5
162	R:R:F186	R:R:Q182	4.68	No	Yes	0	5	5
163	R:R:Q182	R:R:V237	5.73	Yes	No	0	5	8
164	R:R:L241	R:R:Q182	9.32	No	Yes	0	5	5
165	R:R:L183	R:R:M187	5.65	No	No	0	4	5
166	R:R:F185	R:R:F186	9.65	Yes	No	0	8	5
167	R:R:F185	R:R:L189	8.53	Yes	Yes	0	8	6
168	R:R:F185	R:R:F229	5.36	Yes	No	0	8	9
169	R:R:F185	R:R:L234	3.65	Yes	Yes	0	8	5
170	R:R:F185	R:R:V237	6.55	Yes	No	0	8	8
171	R:R:L189	R:R:L193	5.54	Yes	No	0	6	4
172	R:R:F229	R:R:I192	3.77	No	No	0	9	8
173	R:R:F194	R:R:K198	8.69	No	No	3	5	4
174	R:R:F197	R:R:K198	4.96	No	No	0	1	4
175	R:R:I199	R:R:I222	5.89	No	No	0	8	7
176	R:R:R204	R:R:V200	6.54	No	No	0	4	5
177	R:R:T219	R:R:V200	4.76	No	No	0	6	5
178	R:R:R205	R:R:W201	16.99	No	No	0	4	3
179	R:R:L203	R:R:M215	5.65	No	No	0	8	7
180	R:R:M223	R:R:R204	3.72	No	No	0	5	4
181	R:R:Q208	R:R:R211	3.5	No	No	0	3	3
182	R:R:L209	R:R:M215	5.65	No	No	0	2	7
183	R:R:Q212	R:R:R214	10.51	No	No	0	3	4
184	R:R:M215	R:R:Q212	4.08	No	No	0	7	3
185	R:R:F221	R:R:K217	6.2	No	No	0	8	7
186	R:R:K217	R:R:P283	5.02	No	No	0	7	5
187	R:R:F221	R:R:S281	10.57	No	No	0	8	7
188	R:R:V225	R:R:Y278	8.83	No	Yes	0	8	9
189	R:R:F229	R:R:Y233	9.28	No	Yes	0	9	9
190	R:R:C232	R:R:N270	6.3	No	No	0	9	9
191	R:R:T267	R:R:Y233	8.74	No	Yes	0	8	9
192	R:R:N270	R:R:Y233	13.96	No	Yes	0	9	9
193	R:R:P235	R:R:T263	3.5	No	No	0	9	7
194	R:R:F266	R:R:P235	5.78	No	No	0	7	9
195	R:R:F243	R:R:R240	11.76	No	Yes	4	4	5
196	R:R:L244	R:R:R240	8.5	Yes	Yes	4	5	5
197	R:R:T246	R:R:Y242	4.99	Yes	No	0	3	4
198	R:R:V256	R:R:Y242	3.79	No	No	0	3	4
199	R:R:F243	R:R:L244	3.65	No	Yes	4	4	5
200	R:R:S250	R:R:T246	6.4	No	Yes	0	2	3
201	R:R:P248	R:R:V247	3.53	No	No	0	1	3
202	R:R:D253	R:R:S250	4.42	Yes	No	0	2	2
203	R:R:D253	R:R:P254	4.83	Yes	No	0	2	2
204	R:R:D253	R:R:V256	7.3	Yes	No	0	2	3
205	R:R:H257	R:R:H261	13.14	Yes	Yes	0	4	5
206	R:R:T267	R:R:Y268	6.24	No	Yes	0	8	7
207	R:R:D274	R:R:N270	6.73	Yes	No	0	9	9
208	R:R:L273	R:R:M272	5.65	No	No	0	7	8
209	R:R:D274	R:R:Y278	5.75	Yes	Yes	1	9	9
210	R:R:F280	R:R:L276	4.87	No	No	0	7	6
211	R:R:V277	R:R:Y278	3.79	No	Yes	0	8	9
212	R:R:F280	R:R:Y279	5.16	No	Yes	0	7	7
213	R:R:F285	R:R:Y279	4.13	No	Yes	1	9	7
214	R:R:F285	R:R:S282	11.89	No	No	0	9	8
215	R:R:K48	R:R:P49	3.35	No	Yes	0	7	7
216	R:R:L234	R:R:P235	3.28	Yes	No	0	5	9
217	R:R:H177	R:R:Y149	3.27	No	Yes	0	5	7
218	R:R:S102	R:R:S271	3.26	No	No	0	9	9
219	R:R:A25	R:R:M269	3.22	No	No	0	7	4
220	R:R:V104	R:R:V143	3.21	No	No	0	6	7
221	R:R:V117	R:R:V118	3.21	No	Yes	0	8	7
222	R:R:S236	R:R:T263	3.2	No	No	0	6	7
223	R:R:S249	R:R:T246	3.2	No	Yes	0	1	3
224	R:R:G258	R:R:H257	3.18	No	Yes	0	1	4
225	R:R:A58	R:R:L37	3.15	No	No	0	8	8
226	R:R:I222	R:R:S196	3.1	No	No	0	7	8
227	R:R:I262	R:R:V17	3.07	No	No	0	5	5
228	R:R:I23	R:R:T72	3.04	No	No	0	5	7
229	R:R:F62	R:R:G34	3.01	Yes	No	0	7	4
230	R:R:L21	R:R:S265	3	No	No	0	4	5
231	R:R:L234	R:R:S238	3	Yes	No	0	5	6
232	R:R:L28	R:R:V24	2.98	No	No	0	5	5
233	R:R:L203	R:R:V117	2.98	No	No	0	8	8
234	R:R:L244	R:R:V247	2.98	Yes	No	0	5	3
235	R:R:L203	R:R:T219	2.95	No	No	0	8	6
236	R:R:I14	R:R:I262	2.94	Yes	No	0	4	5
237	R:R:D112	R:R:S50	2.94	No	No	0	8	7
238	R:R:D253	R:R:S255	2.94	Yes	No	0	2	4
239	R:R:A82	R:R:H80	2.93	No	No	0	3	5
240	R:R:I135	R:R:L139	2.85	No	No	0	6	7
241	R:R:I230	R:R:L189	2.85	No	Yes	0	6	6
242	R:R:I230	R:R:L234	2.85	No	Yes	0	6	5
243	R:R:L64	R:R:M65	2.83	Yes	No	0	7	6
244	R:R:G101	R:R:W140	2.81	No	Yes	0	7	9
245	R:R:C41	R:R:F42	2.79	No	No	0	4	4
246	R:R:P19	R:R:Y75	2.78	No	Yes	0	6	5
247	R:R:A30	R:R:F26	2.77	No	No	0	5	7
248	R:R:A133	R:R:R130	2.77	No	No	0	4	4
249	R:R:L260	R:R:L264	2.77	No	No	0	4	6
250	R:R:R78	R:R:S15	2.64	No	No	0	3	5
251	R:R:F221	R:R:V224	2.62	No	No	0	8	6
252	R:R:F243	R:R:V256	2.62	No	No	0	4	3
253	R:R:A60	R:R:W140	2.59	No	Yes	0	8	9
254	R:R:I222	R:R:R113	2.51	No	No	0	7	9
255	R:R:K217	R:R:R220	2.48	No	No	0	7	5
256	R:R:L22	R:R:R71	2.43	No	Yes	0	7	6
257	R:R:F83	R:R:R77	2.14	No	No	0	7	4
258	R:R:G84	R:R:P87	2.03	No	No	0	8	6
259	R:R:F197	R:R:W201	2	No	No	0	1	3
260	R:R:G91	R:R:T94	1.82	No	No	0	6	4
261	R:R:A110	R:R:C195	1.81	No	No	0	9	8
262	R:R:P283	R:R:S282	1.78	No	No	0	5	8
263	R:R:G11	R:R:I14	1.76	No	Yes	0	4	4
264	R:R:C157	R:R:S164	1.72	No	No	0	3	4
265	R:R:G32	R:R:L31	1.71	No	No	0	7	4
266	R:R:C137	R:R:V136	1.71	No	Yes	0	5	7
267	R:R:G146	R:R:L145	1.71	No	No	0	4	3
268	R:R:G190	R:R:L189	1.71	No	Yes	0	3	6
269	R:R:A226	R:R:S196	1.71	No	No	0	7	8
270	R:R:C232	R:R:V228	1.71	No	No	0	9	7
271	R:R:A100	R:R:V143	1.7	No	No	0	6	7
272	R:R:C232	R:R:T231	1.69	No	No	0	9	6
273	R:R:M44	R:R:P286	1.68	No	No	0	6	8
274	R:R:A96	R:R:T147	1.68	No	No	0	5	6
275	R:R:A123	R:R:T126	1.68	No	No	0	5	4
276	R:R:M187	R:R:P188	1.68	No	No	0	5	9
277	R:R:A239	R:R:T263	1.68	No	No	0	4	7
278	R:R:S128	R:R:V131	1.62	No	No	0	6	4
279	R:R:I14	R:R:S15	1.55	Yes	No	0	4	5
280	R:R:I86	R:R:V90	1.54	No	No	0	3	5
281	R:R:A173	R:R:D178	1.54	No	No	0	3	4
282	R:R:H119	R:R:P120	1.53	Yes	No	0	7	7
283	R:R:H121	R:R:P120	1.53	No	No	0	6	7
284	R:R:K45	R:R:T46	1.5	No	No	0	6	6
285	R:R:L28	R:R:V27	1.49	No	No	0	5	6
286	R:R:L31	R:R:V27	1.49	No	No	0	4	6
287	R:R:L151	R:R:V148	1.49	No	No	0	5	3
288	R:R:L142	R:R:T138	1.47	No	No	0	4	3
289	R:R:A123	R:R:H122	1.46	No	No	0	5	4
290	R:R:E171	R:R:S172	1.44	No	No	0	1	1
291	R:R:I179	R:R:L183	1.43	No	No	0	4	4
292	R:R:A82	R:R:R77	1.38	No	No	0	3	4
293	R:R:H80	R:R:V163	1.38	No	No	0	5	5
294	R:R:L209	R:R:R206	1.21	No	No	0	2	5
295	R:R:T246	R:R:W245	1.21	Yes	No	0	3	4
296	R:R:E10	R:R:R8	1.16	No	No	0	4	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.28167	6	0	0
2	R:R:I14	2.92	5	0	4
3	R:R:F40	6.745	4	1	7
4	R:R:P49	4.306	5	6	7
5	R:R:Y53	6.55	4	6	7
6	R:R:F55	6.96667	6	0	6
7	R:R:N56	7.0575	4	5	9
8	R:R:L57	5.8575	4	1	9
9	R:R:D61	8.2125	4	1	9
10	R:R:F62	4.13	4	0	7
11	R:R:L64	6.06	4	0	7
12	R:R:R71	6.385	4	2	6
13	R:R:Y74	7.976	5	2	5
14	R:R:Y75	8.15667	6	2	5
15	R:R:R79	7.065	4	2	5
16	R:R:W81	7.226	5	2	8
17	R:R:M97	7.2025	4	7	6
18	R:R:N98	6.27	4	0	8
19	R:R:Y114	8.29	6	3	9
20	R:R:V118	6.555	4	3	7
21	R:R:H119	4.8	5	3	7
22	R:R:V136	5.2	4	5	7
23	R:R:W140	5.955	4	5	9
24	R:R:Y149	6.15	4	8	7
25	R:R:E166	7.46	5	2	4
26	R:R:F168	8.106	5	4	4
27	R:R:F181	7.6975	4	4	5
28	R:R:Q182	6.3975	4	0	5
29	R:R:F185	6.748	5	0	8
30	R:R:L189	4.6575	4	0	6
31	R:R:Y233	10.4125	4	0	9
32	R:R:L234	3.195	4	0	5
33	R:R:R240	8.384	5	4	5
34	R:R:L244	6.4975	4	4	5
35	R:R:T246	3.95	4	0	3
36	R:R:D253	4.8725	4	0	2
37	R:R:H257	8.29	5	0	4
38	R:R:H261	9.5	4	0	5
39	R:R:Y268	7.135	4	0	7
40	R:R:D274	7.064	5	1	9
41	R:R:Y278	5.86125	8	1	9
42	R:R:Y279	5.86	5	1	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R71	83.358	9.74	Yes	Yes	0	0	6
2	R:R:R71	R:R:Y74	28.4753	8.23	Yes	Yes	2	6	5
3	R:R:H257	R:R:R79	15.2431	7.9	Yes	Yes	0	4	5
4	R:R:H257	R:R:I9	14.2738	7.95	Yes	No	0	4	4
5	R:R:R71	R:R:Y75	49.8613	5.14	Yes	Yes	2	6	5
6	R:R:H261	R:R:Y75	19.0938	9.8	Yes	Yes	0	5	5
7	R:R:M18	R:R:Y75	18.4856	19.16	No	Yes	0	5	5
8	R:R:I14	R:R:M18	10.157	4.37	Yes	No	0	4	5
9	R:R:H261	R:R:I14	10.8108	3.98	Yes	Yes	0	5	4
10	L:L:?1	R:R:Y268	100	10.58	Yes	Yes	0	0	7
11	R:R:L64	R:R:Y268	83.1604	7.03	Yes	Yes	0	7	7
12	R:R:L64	R:R:S271	61.4361	7.51	Yes	No	0	7	9
13	R:R:D61	R:R:S271	61.4513	7.36	Yes	No	0	9	9
14	R:R:D61	R:R:N33	24.7311	8.08	Yes	No	0	9	9
15	R:R:L64	R:R:N98	29.6727	6.87	Yes	Yes	0	7	8
16	R:R:L63	R:R:N98	20.7245	9.61	No	Yes	0	7	8
17	R:R:I66	R:R:L63	20.2342	4.28	No	No	0	5	7
18	R:R:F62	R:R:I66	20.1961	5.02	Yes	No	0	7	5
19	R:R:F62	R:R:N33	21.2415	3.62	Yes	No	0	7	9
20	R:R:D61	R:R:L57	22.6328	5.43	Yes	Yes	1	9	9
21	R:R:L57	R:R:Y278	22.0132	7.03	Yes	Yes	1	9	9
22	R:R:L54	R:R:Y278	36.7887	4.69	No	Yes	1	8	9
23	R:R:F40	R:R:L54	42.9543	4.87	Yes	No	1	7	8
24	R:R:F40	R:R:Y279	10.2634	10.32	Yes	Yes	1	7	7
25	R:R:D274	R:R:D61	25.2936	11.98	Yes	Yes	1	9	9
26	R:R:D274	R:R:Y278	61.018	5.75	Yes	Yes	1	9	9
27	R:R:T267	R:R:Y268	25.4647	6.24	No	Yes	0	8	7
28	R:R:T267	R:R:Y233	25.4267	8.74	No	Yes	0	8	9
29	R:R:N270	R:R:Y233	43.4143	13.96	No	Yes	0	9	9
30	R:R:D274	R:R:N270	42.9734	6.73	Yes	No	0	9	9
31	R:R:F62	R:R:L37	36.5302	4.87	Yes	No	0	7	8
32	R:R:F55	R:R:L37	34.7626	3.65	Yes	No	0	6	8
33	R:R:F55	R:R:N56	41.6619	3.62	Yes	Yes	0	6	9
34	R:R:N56	R:R:V136	27.2475	10.35	Yes	Yes	5	9	7
35	R:R:V136	R:R:V52	25.0162	4.81	Yes	No	0	7	7
36	R:R:A132	R:R:V52	23.4804	5.09	No	No	0	8	7
37	R:R:A132	R:R:P49	12.6354	3.74	No	Yes	6	8	7
38	R:R:W81	R:R:Y74	14.2434	7.72	Yes	Yes	2	8	5
39	L:L:?1	R:R:S167	28.7946	6.02	Yes	No	0	0	4
40	R:R:L92	R:R:S167	20.3938	4.5	No	No	0	6	4
41	R:R:H155	R:R:L92	15.6916	7.71	No	No	0	4	6
42	R:R:H155	R:R:R89	12.2629	3.39	No	No	0	4	6
43	R:R:N56	R:R:W140	12.5366	3.39	Yes	Yes	5	9	9
44	R:R:G101	R:R:W140	10.043	2.81	No	Yes	0	7	9
45	R:R:E184	R:R:I103	16.068	5.47	No	No	0	5	8
46	R:R:R113	R:R:Y278	56.6693	8.23	No	Yes	1	9	9
47	R:R:I222	R:R:R113	62.5157	2.51	No	No	0	7	9
48	R:R:I199	R:R:I222	57.574	5.89	No	No	0	8	7
49	R:R:I199	R:R:V117	56.0193	7.68	No	No	0	8	8
50	R:R:V117	R:R:V118	36.3211	3.21	No	Yes	0	8	7
51	R:R:V118	R:R:Y114	17.1551	12.62	Yes	Yes	3	7	9
52	R:R:H119	R:R:V118	15.4446	5.54	Yes	Yes	3	7	7
53	R:R:F168	R:R:S167	18.4133	3.96	Yes	No	0	4	4
54	R:R:F168	R:R:H177	13.8252	9.05	Yes	No	0	4	5
55	L:L:?1	R:R:L264	15.3381	4.16	Yes	No	0	0	6
56	R:R:F168	R:R:L264	13.2588	6.09	Yes	No	0	4	6
57	R:R:E184	R:R:F181	14.863	3.5	No	Yes	0	5	5
58	R:R:F168	R:R:F181	10.3965	17.15	Yes	Yes	4	4	5
59	R:R:F168	R:R:R240	15.1861	4.28	Yes	Yes	4	4	5
60	R:R:F181	R:R:Q182	10.5067	5.86	Yes	Yes	0	5	5
61	R:R:F229	R:R:Y233	15.1215	9.28	No	Yes	0	9	9
62	R:R:F185	R:R:F229	13.7454	5.36	Yes	No	0	8	9
63	R:R:F185	R:R:L234	10.1114	3.65	Yes	Yes	0	8	5
64	R:R:L203	R:R:V117	19.3295	2.98	No	No	0	8	8
65	R:R:F285	R:R:F40	13.6123	5.36	No	Yes	1	9	7
66	R:R:F285	R:R:S282	12.2553	11.89	No	No	0	9	8
67	R:R:P283	R:R:S282	10.4953	1.78	No	No	0	5	8
68	R:R:F243	R:R:R240	14.517	11.76	No	Yes	4	4	5
69	R:R:F243	R:R:V256	13.3387	2.62	No	No	0	4	3
70	R:R:I103	R:R:Y233	17.0525	9.67	No	Yes	0	8	9
71	R:R:F40	R:R:F55	24.3851	6.43	Yes	Yes	0	7	6
72	R:R:F181	R:R:R240	10.6702	4.28	Yes	Yes	4	5	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:R71	9.74	0	Yes	Yes	0	6	0	1
L:L:?1	R:R:L95	8.32	0	Yes	No	0	6	0	1
L:L:?1	R:R:R99	4.87	0	Yes	No	0	8	0	1
L:L:?1	R:R:S167	6.02	0	Yes	No	0	4	0	1
L:L:?1	R:R:L264	4.16	0	Yes	No	0	6	0	1
L:L:?1	R:R:Y268	10.58	0	Yes	Yes	0	7	0	1
R:R:L64	R:R:Y268	7.03	0	Yes	Yes	7	7	2	1
R:R:L68	R:R:Y268	4.69	0	No	Yes	8	7	2	1
R:R:R71	R:R:Y74	8.23	2	Yes	Yes	6	5	1	2
R:R:R71	R:R:Y75	5.14	2	Yes	Yes	6	5	1	2
R:R:Y74	R:R:Y75	7.94	2	Yes	Yes	5	5	2	2
R:R:L92	R:R:S167	4.5	0	No	No	6	4	2	1
R:R:E184	R:R:R99	4.65	0	No	No	5	8	2	1
R:R:F168	R:R:S167	3.96	4	Yes	No	4	4	2	1
R:R:F168	R:R:L264	6.09	4	Yes	No	4	6	2	1
R:R:T267	R:R:Y268	6.24	0	No	Yes	8	7	2	1
R:R:L260	R:R:L264	2.77	0	No	No	4	6	2	1
R:R:L22	R:R:R71	2.43	0	No	Yes	7	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8Z8A_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.39
Number of Linked Nodes	263
Number of Links	296
Number of Hubs	42
Number of Links mediated by Hubs	153
Number of Communities	8
Number of Nodes involved in Communities	45
Number of Links involved in Communities	60

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	57698
Length Of Smallest Path	3
Average Path Length	13.1821
Length of Longest Path	24
Minimum Path Strength	1.49
Average Path Strength	6.49011
Maximum Path Strength	14.48
Minimum Path Correlation	0.7
Average Path Correlation	0.92285
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	47.2814
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.2729
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	2OP
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	2OP
Name	L-Lactic acid
Synonyms	(S)-(+)-lactic acid
Identifier
Formula	C3 H6 O3
Molecular Weight	90.078
SMILES
PubChem	107689
Formal Charge	0
Total Atoms	12
Total Chiral Atoms	1
Total Bonds	11
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9BXC0
Sequence	>8Z8A_nogp_Chain_R C C R I E G D T I S Q V M P P L L I V A F V L G A L G N G V A L C G F C F H M K T W K P S T V Y L F N L A V A D F L L M I C L P F R T D Y Y L R R R H W A F G D I P C R V G L F T L A M N R A G S I V F L T V V A A D R Y F K V V H P H H A V N T I S T R V A A G I V C T L W A L V I L G T V Y L L L E N H L C V Q E T A V S C E S F I M E S A N G W H D I M F Q L E F F M P L G I I L F C S F K I V W S L R R R Q Q L A R Q A R M K K A T R F I M V V A I V F I T C Y L P S V S A R L Y F L W T V P S S A C D P S V H G A L H I T L S F T Y M N S M L D P L V Y Y F S S P S F P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9IZD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	CHBA	-	Gi1/β1/γ2	3.16	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9IZD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	CHBA	-		3.16	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9J8Z	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	-	-	Gi1/β1/γ2	3.36	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9J8Z (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	-	-		3.36	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	8Z8A	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	Lactate	-	Gi1/β1/γ2	2.82	2025-10-29	To be published
	8Z8A (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	Lactate	-		2.82	2025-10-29	To be published
	8Z8B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	-	-	Gi1/β1/γ2	2.65	2025-10-29	To be published
	8Z8B (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	-	-		2.65	2025-10-29	To be published
	8Z87	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	CHBA	-	Gi1/β1/γ2	2.73	2025-11-05	To be published
	8Z87 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	CHBA	-		2.73	2025-11-05	To be published
	9KT9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	3,5-DHBA	-	Gi1/β1/γ2	2.7	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	3,5-DHBA	-		2.7	2025-12-10	10.1021/acs.jmedchem.4c02567

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8Z8A_nogp.zip

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