psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C157	R:R:C6	5.46	No	No	0	3	6
2	R:R:C252	R:R:C7	7.28	No	No	0	7	6
3	R:R:E10	R:R:R8	6.98	No	No	0	4	2
4	R:R:Q159	R:R:R8	3.5	No	No	0	3	2
5	R:R:I9	R:R:R79	3.76	No	Yes	0	4	5
6	R:R:C252	R:R:I9	3.27	No	No	0	7	4
7	R:R:H257	R:R:I9	13.26	No	No	0	4	4
8	R:R:G11	R:R:I14	3.53	No	Yes	0	4	4
9	R:R:G258	R:R:I14	3.53	No	Yes	0	1	4
10	R:R:M18	R:R:Y75	15.57	Yes	No	0	5	5
11	R:R:P19	R:R:P20	7.79	No	No	0	6	4
12	R:R:L76	R:R:P19	6.57	No	No	0	3	6
13	R:R:L22	R:R:Y268	3.52	No	Yes	0	7	7
14	R:R:F26	R:R:L68	3.65	No	No	0	7	8
15	R:R:F26	R:R:P69	11.56	No	No	0	7	9
16	R:R:L28	R:R:M272	9.9	No	Yes	0	5	8
17	R:R:G29	R:R:M65	5.24	No	No	0	8	6
18	R:R:G29	R:R:M272	3.49	No	Yes	0	8	8
19	R:R:G32	R:R:L31	3.42	No	No	0	7	4
20	R:R:G32	R:R:P275	4.06	No	No	0	7	9
21	R:R:D61	R:R:N33	5.39	Yes	No	0	9	9
22	R:R:F62	R:R:N33	6.04	No	No	0	7	9
23	R:R:N33	R:R:P275	6.52	No	No	0	9	9
24	R:R:F280	R:R:V35	3.93	No	No	0	7	5
25	R:R:A36	R:R:Y279	4	No	Yes	0	8	7
26	R:R:F55	R:R:L37	3.65	Yes	No	0	6	8
27	R:R:F62	R:R:L37	3.65	No	No	0	7	8
28	R:R:F40	R:R:L54	4.87	Yes	No	1	7	8
29	R:R:F40	R:R:F55	7.5	Yes	Yes	0	7	6
30	R:R:F40	R:R:Y279	7.22	Yes	Yes	1	7	7
31	R:R:F285	R:R:F40	5.36	Yes	Yes	1	9	7
32	R:R:C41	R:R:F42	5.59	No	No	0	4	4
33	R:R:F42	R:R:H43	4.53	No	No	0	4	5
34	R:R:M44	R:R:T51	9.03	No	No	0	6	8
35	R:R:T51	R:R:W47	8.49	No	No	0	8	6
36	R:R:F55	R:R:W47	15.03	Yes	No	0	6	6
37	R:R:P49	R:R:Y53	4.17	Yes	No	0	7	7
38	R:R:A132	R:R:P49	3.74	No	Yes	0	8	7
39	R:R:D112	R:R:S50	4.42	No	No	0	8	7
40	R:R:A132	R:R:V52	5.09	No	No	0	8	7
41	R:R:V136	R:R:V52	4.81	No	No	0	7	7
42	R:R:V108	R:R:Y53	8.83	No	No	0	6	7
43	R:R:D112	R:R:Y53	8.05	No	No	0	8	7
44	R:R:L54	R:R:V109	4.47	No	No	1	8	9
45	R:R:L54	R:R:Y278	3.52	No	Yes	1	8	9
46	R:R:F55	R:R:V59	5.24	Yes	No	0	6	5
47	R:R:F105	R:R:N56	15.71	Yes	No	3	7	9
48	R:R:N56	R:R:V136	11.82	No	No	3	9	7
49	R:R:N56	R:R:W140	10.17	No	Yes	3	9	9
50	R:R:D61	R:R:L57	5.43	Yes	Yes	1	9	9
51	R:R:L106	R:R:L57	5.54	No	Yes	1	8	9
52	R:R:D274	R:R:L57	5.43	Yes	Yes	1	9	9
53	R:R:L57	R:R:Y278	4.69	Yes	Yes	1	9	9
54	R:R:D61	R:R:S102	5.89	Yes	No	0	9	9
55	R:R:D61	R:R:S271	10.31	Yes	No	0	9	9
56	R:R:D274	R:R:D61	7.98	Yes	Yes	1	9	9
57	R:R:F62	R:R:I66	7.54	No	No	0	7	5
58	R:R:L63	R:R:N98	13.73	No	No	0	7	8
59	R:R:L64	R:R:N98	5.49	No	No	0	7	8
60	R:R:L64	R:R:S271	4.5	No	No	0	7	9
61	R:R:C67	R:R:T94	8.45	No	No	0	6	4
62	R:R:C67	R:R:L95	3.17	No	No	0	6	6
63	R:R:R71	R:R:Y74	9.26	Yes	Yes	0	6	5
64	R:R:R71	R:R:Y75	6.17	Yes	No	0	6	5
65	R:R:L92	R:R:R71	3.64	No	Yes	0	6	6
66	R:R:L95	R:R:R71	3.64	No	Yes	0	6	6
67	R:R:D73	R:R:R77	11.91	No	No	0	3	4
68	R:R:D73	R:R:F83	4.78	No	Yes	0	3	7
69	R:R:R79	R:R:Y74	13.38	Yes	Yes	2	5	5
70	R:R:W81	R:R:Y74	3.86	No	Yes	0	8	5
71	R:R:E166	R:R:Y74	11.22	Yes	Yes	2	4	5
72	R:R:H261	R:R:Y75	11.98	Yes	No	0	5	5
73	R:R:E166	R:R:R79	10.47	Yes	Yes	2	4	5
74	R:R:H261	R:R:R79	6.77	Yes	Yes	2	5	5
75	R:R:H80	R:R:V163	9.69	No	No	0	5	5
76	R:R:F83	R:R:W81	19.04	Yes	No	0	7	8
77	R:R:C88	R:R:W81	13.06	No	No	0	9	8
78	R:R:D85	R:R:R89	8.34	No	No	0	3	6
79	R:R:D85	R:R:N154	6.73	No	No	0	3	4
80	R:R:D85	R:R:L156	4.07	No	No	0	3	5
81	R:R:I86	R:R:P87	3.39	No	No	0	3	6
82	R:R:C88	R:R:L92	3.17	No	No	0	9	6
83	R:R:C165	R:R:C88	7.28	No	No	0	9	9
84	R:R:H155	R:R:L92	3.86	No	No	0	4	6
85	R:R:F93	R:R:M97	7.46	No	Yes	0	5	6
86	R:R:F93	R:R:L151	4.87	No	No	0	5	5
87	R:R:L95	R:R:Y268	3.52	No	Yes	0	6	7
88	R:R:M97	R:R:N98	7.01	Yes	No	0	6	8
89	R:R:M97	R:R:T147	4.52	Yes	No	0	6	6
90	R:R:F181	R:R:R99	11.76	Yes	No	0	5	8
91	R:R:E184	R:R:R99	9.3	No	No	0	5	8
92	R:R:R99	R:R:Y233	12.35	No	Yes	0	8	9
93	R:R:A100	R:R:V143	3.39	No	No	0	6	7
94	R:R:E184	R:R:I103	4.1	No	No	0	5	8
95	R:R:I103	R:R:P188	3.39	No	No	0	8	9
96	R:R:I103	R:R:Y233	10.88	No	Yes	0	8	9
97	R:R:L139	R:R:V104	5.96	No	No	0	7	6
98	R:R:F105	R:R:V136	5.24	Yes	No	3	7	7
99	R:R:F105	R:R:L139	6.09	Yes	No	0	7	7
100	R:R:F105	R:R:W140	14.03	Yes	Yes	3	7	9
101	R:R:D274	R:R:L106	6.79	Yes	No	1	9	8
102	R:R:L106	R:R:Y278	4.69	No	Yes	1	8	9
103	R:R:P188	R:R:T107	3.5	No	No	0	9	7
104	R:R:I191	R:R:T107	6.08	No	No	0	6	7
105	R:R:R113	R:R:V109	6.54	No	No	1	9	9
106	R:R:V109	R:R:Y278	6.31	No	Yes	1	9	9
107	R:R:D112	R:R:K116	9.68	No	No	0	8	8
108	R:R:I222	R:R:R113	5.01	No	No	0	7	9
109	R:R:R113	R:R:Y278	8.23	No	Yes	1	9	9
110	R:R:F115	R:R:Y114	9.28	No	Yes	6	5	9
111	R:R:V118	R:R:Y114	10.09	No	Yes	0	7	9
112	R:R:H119	R:R:Y114	3.27	No	Yes	6	7	9
113	R:R:C195	R:R:Y114	4.03	No	Yes	0	8	9
114	R:R:K198	R:R:Y114	5.97	Yes	Yes	0	4	9
115	R:R:F115	R:R:H119	3.39	No	No	6	5	7
116	R:R:K116	R:R:N125	4.2	No	No	0	8	3
117	R:R:I199	R:R:V117	7.68	No	No	0	8	8
118	R:R:L203	R:R:V117	4.47	No	No	0	8	8
119	R:R:S202	R:R:V118	6.46	No	No	0	5	7
120	R:R:H122	R:R:V124	8.3	No	No	0	4	5
121	R:R:I127	R:R:V131	4.61	No	No	0	7	4
122	R:R:S128	R:R:T129	3.2	No	No	0	6	3
123	R:R:R130	R:R:T129	3.88	No	No	0	4	3
124	R:R:L150	R:R:Y149	8.21	No	No	0	5	7
125	R:R:H177	R:R:Y149	10.89	No	No	0	5	7
126	R:R:H155	R:R:L150	6.43	No	No	0	4	5
127	R:R:L156	R:R:V163	4.47	No	No	0	5	5
128	R:R:C165	R:R:L156	4.76	No	No	0	9	5
129	R:R:C157	R:R:S164	3.44	No	No	0	3	4
130	R:R:V158	R:R:V163	3.21	No	No	0	1	5
131	R:R:E160	R:R:Q159	10.19	No	No	0	2	3
132	R:R:E166	R:R:I169	4.1	Yes	Yes	2	4	4
133	R:R:E166	R:R:H261	8.62	Yes	Yes	2	4	5
134	R:R:F168	R:R:S167	9.25	No	No	0	4	4
135	R:R:F168	R:R:H177	11.31	No	No	0	4	5
136	R:R:F168	R:R:F181	17.15	No	Yes	0	4	5
137	R:R:H257	R:R:I169	7.95	No	Yes	0	4	4
138	R:R:I169	R:R:L260	11.42	Yes	Yes	2	4	4
139	R:R:H261	R:R:I169	13.26	Yes	Yes	2	5	4
140	R:R:E171	R:R:M170	8.12	No	No	0	1	3
141	R:R:E171	R:R:F243	3.5	No	Yes	0	1	4
142	R:R:N174	R:R:S172	10.43	No	No	0	3	1
143	R:R:H177	R:R:N174	7.65	No	No	0	5	3
144	R:R:D178	R:R:R240	13.1	No	Yes	0	4	5
145	R:R:D178	R:R:L244	6.79	No	No	0	4	5
146	R:R:F181	R:R:Q182	4.68	Yes	No	0	5	5
147	R:R:F181	R:R:R240	4.28	Yes	Yes	0	5	5
148	R:R:Q182	R:R:V237	5.73	No	No	0	5	8
149	R:R:F185	R:R:F186	5.36	Yes	No	0	8	5
150	R:R:F185	R:R:F229	4.29	Yes	No	5	8	9
151	R:R:F185	R:R:Y233	6.19	Yes	Yes	5	8	9
152	R:R:F185	R:R:L234	3.65	Yes	No	0	8	5
153	R:R:F185	R:R:V237	9.18	Yes	No	0	8	8
154	R:R:G190	R:R:L189	3.42	No	No	0	3	6
155	R:R:L189	R:R:L193	6.92	No	No	0	6	4
156	R:R:F229	R:R:I192	6.28	No	No	0	9	8
157	R:R:F194	R:R:K198	7.44	No	Yes	0	5	4
158	R:R:K198	R:R:W201	3.48	Yes	No	0	4	3
159	R:R:I199	R:R:I222	4.42	No	No	0	8	7
160	R:R:T219	R:R:V200	3.17	No	No	0	6	5
161	R:R:R205	R:R:W201	13	No	No	0	4	3
162	R:R:L203	R:R:M215	7.07	No	No	0	8	7
163	R:R:L203	R:R:T219	4.42	No	No	0	8	6
164	R:R:L209	R:R:Q212	3.99	No	No	0	2	3
165	R:R:L209	R:R:M215	14.14	No	No	0	2	7
166	R:R:F221	R:R:S281	7.93	No	No	0	8	7
167	R:R:V225	R:R:V277	3.21	No	No	1	8	8
168	R:R:V225	R:R:Y278	7.57	No	Yes	1	8	9
169	R:R:F229	R:R:Y233	7.22	No	Yes	5	9	9
170	R:R:C232	R:R:N270	7.87	No	No	0	9	9
171	R:R:T267	R:R:Y233	7.49	No	Yes	0	8	9
172	R:R:N270	R:R:Y233	5.81	No	Yes	0	9	9
173	R:R:P235	R:R:T263	3.5	No	No	0	9	7
174	R:R:F266	R:R:P235	7.22	No	No	0	7	9
175	R:R:S236	R:R:T263	3.2	No	No	0	6	7
176	R:R:L264	R:R:S236	6.01	No	No	0	6	6
177	R:R:F243	R:R:R240	8.55	Yes	Yes	2	4	5
178	R:R:L260	R:R:R240	3.64	Yes	Yes	2	4	5
179	R:R:T246	R:R:Y242	4.99	No	No	0	3	4
180	R:R:F243	R:R:V256	3.93	Yes	No	0	4	3
181	R:R:F243	R:R:L260	3.65	Yes	Yes	2	4	4
182	R:R:S249	R:R:T246	4.8	No	No	7	1	3
183	R:R:S250	R:R:T246	6.4	No	No	7	2	3
184	R:R:P248	R:R:V247	5.3	No	No	0	1	3
185	R:R:S249	R:R:S250	3.26	No	No	7	1	2
186	R:R:S250	R:R:V256	3.23	No	No	0	2	3
187	R:R:D253	R:R:P254	8.05	No	No	0	2	2
188	R:R:D253	R:R:S255	4.42	No	No	0	2	4
189	R:R:D253	R:R:V256	10.22	No	No	0	2	3
190	R:R:T267	R:R:Y268	4.99	No	Yes	0	8	7
191	R:R:M269	R:R:M272	4.33	No	Yes	4	4	8
192	R:R:D274	R:R:N270	4.04	Yes	No	0	9	9
193	R:R:D274	R:R:Y278	5.75	Yes	Yes	1	9	9
194	R:R:F280	R:R:L276	3.65	No	No	0	7	6
195	R:R:V277	R:R:Y278	3.79	No	Yes	1	8	9
196	R:R:F280	R:R:Y279	6.19	No	Yes	0	7	7
197	R:R:F285	R:R:Y279	9.28	Yes	Yes	1	9	7
198	R:R:P286	R:R:Y279	6.95	No	Yes	0	8	7
199	R:R:S281	R:R:S282	3.26	No	No	0	7	8
200	R:R:F285	R:R:S284	5.28	Yes	No	0	9	6
201	R:R:A58	R:R:L37	3.15	No	No	0	8	8
202	R:R:A239	R:R:L260	3.15	No	Yes	0	4	4
203	R:R:I222	R:R:S196	3.1	No	No	0	7	8
204	R:R:M18	R:R:S265	3.07	Yes	No	0	5	5
205	R:R:H43	R:R:P286	3.05	No	No	0	5	8
206	R:R:H121	R:R:P120	3.05	No	No	0	6	7
207	R:R:I23	R:R:T72	3.04	No	No	0	5	7
208	R:R:M97	R:R:V143	3.04	Yes	No	0	6	7
209	R:R:L21	R:R:S265	3	No	No	0	4	5
210	R:R:L234	R:R:S238	3	No	No	0	5	6
211	R:R:L273	R:R:V228	2.98	No	No	0	7	7
212	R:R:L22	R:R:T72	2.95	No	No	0	7	7
213	R:R:A82	R:R:H80	2.93	No	No	0	3	5
214	R:R:I14	R:R:M18	2.92	Yes	Yes	0	4	5
215	R:R:G39	R:R:Y279	2.9	No	Yes	0	8	7
216	R:R:F83	R:R:P87	2.89	Yes	No	0	7	6
217	R:R:E166	R:R:S164	2.87	Yes	No	0	4	4
218	R:R:I135	R:R:L139	2.85	No	No	0	6	7
219	R:R:I179	R:R:L183	2.85	No	No	0	4	4
220	R:R:I230	R:R:L189	2.85	No	No	0	6	6
221	R:R:I230	R:R:L234	2.85	No	No	0	6	5
222	R:R:L21	R:R:M269	2.83	No	No	0	4	4
223	R:R:R78	R:R:S15	2.64	No	No	0	3	5
224	R:R:R206	R:R:S202	2.64	No	No	0	5	5
225	R:R:F285	R:R:S282	2.64	Yes	No	0	9	8
226	R:R:R204	R:R:V200	2.62	No	No	0	4	5
227	R:R:A60	R:R:W140	2.59	No	Yes	0	8	9
228	R:R:F197	R:R:K198	2.48	No	Yes	0	1	4
229	R:R:K216	R:R:R220	2.48	No	No	0	4	5
230	R:R:V52	R:R:W47	2.45	No	No	0	7	6
231	R:R:V59	R:R:W140	2.45	No	Yes	0	5	9
232	R:R:L68	R:R:Y268	2.34	No	Yes	0	8	7
233	R:R:Q208	R:R:R211	2.34	No	No	0	3	3
234	R:R:Q212	R:R:R214	2.34	No	No	0	3	4
235	R:R:F70	R:R:F83	2.14	No	Yes	0	6	7
236	R:R:C38	R:R:G39	1.96	No	No	0	4	8
237	R:R:A60	R:R:G101	1.95	No	No	0	8	7
238	R:R:G91	R:R:V90	1.84	No	No	0	6	5
239	R:R:G91	R:R:T94	1.82	No	No	0	6	4
240	R:R:A110	R:R:C195	1.81	No	No	0	9	8
241	R:R:P283	R:R:S282	1.78	No	No	0	5	8
242	R:R:P49	R:R:T129	1.75	Yes	No	0	7	3
243	R:R:C232	R:R:V228	1.71	No	No	0	9	7
244	R:R:I127	R:R:P49	1.69	No	Yes	0	7	7
245	R:R:M18	R:R:P19	1.68	Yes	No	0	5	6
246	R:R:A96	R:R:T147	1.68	No	No	0	5	6
247	R:R:A123	R:R:T126	1.68	No	No	0	5	4
248	R:R:M187	R:R:P188	1.68	No	No	0	5	9
249	R:R:A239	R:R:T263	1.68	No	No	0	4	7
250	R:R:K48	R:R:P49	1.67	No	Yes	0	7	7
251	R:R:C195	R:R:I191	1.64	No	No	0	8	6
252	R:R:A226	R:R:I192	1.62	No	No	0	7	8
253	R:R:A25	R:R:M269	1.61	No	No	4	7	4
254	R:R:A25	R:R:M272	1.61	No	Yes	4	7	8
255	R:R:A30	R:R:M65	1.61	No	No	0	5	6
256	R:R:A210	R:R:M215	1.61	No	No	0	3	7
257	R:R:A213	R:R:K217	1.61	No	No	0	3	7
258	R:R:V224	R:R:V228	1.6	No	No	0	6	7
259	R:R:T13	R:R:V17	1.59	No	No	0	3	5
260	R:R:H119	R:R:P120	1.53	No	No	0	7	7
261	R:R:M223	R:R:S196	1.53	No	No	0	5	8
262	R:R:I14	R:R:T13	1.52	Yes	No	0	4	3
263	R:R:I227	R:R:T231	1.52	No	No	0	4	6
264	R:R:K48	R:R:T46	1.5	No	No	0	7	6
265	R:R:L151	R:R:V148	1.49	No	No	0	5	3
266	R:R:L152	R:R:V148	1.49	No	No	0	3	3
267	R:R:L241	R:R:V237	1.49	No	No	0	5	8
268	R:R:L244	R:R:V247	1.49	No	No	0	5	3
269	R:R:I262	R:R:M18	1.46	No	Yes	0	5	5
270	R:R:I144	R:R:M97	1.46	No	Yes	0	4	6
271	R:R:A123	R:R:H122	1.46	No	No	0	5	4
272	R:R:G175	R:R:W176	1.41	No	No	0	3	5
273	R:R:F26	R:R:V27	1.31	No	No	0	7	6
274	R:R:H122	R:R:N125	1.28	No	No	0	4	3
275	R:R:K217	R:R:R220	1.24	No	No	0	7	5
276	R:R:E153	R:R:H155	1.23	No	No	0	4	4
277	R:R:I179	R:R:W176	1.17	No	No	0	4	5
278	R:R:M180	R:R:W176	1.16	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I14	2.875	4	0	4
2	R:R:M18	4.94	5	0	5
3	R:R:F40	6.2375	4	1	7
4	R:R:P49	2.604	5	0	7
5	R:R:F55	7.855	4	0	6
6	R:R:L57	5.2725	4	1	9
7	R:R:D61	7	5	1	9
8	R:R:R71	5.6775	4	0	6
9	R:R:Y74	9.43	4	2	5
10	R:R:R79	8.595	4	2	5
11	R:R:F83	7.2125	4	0	7
12	R:R:M97	4.698	5	0	6
13	R:R:F105	10.2675	4	3	7
14	R:R:Y114	6.528	5	6	9
15	R:R:W140	7.31	4	3	9
16	R:R:E166	7.456	5	2	4
17	R:R:I169	9.1825	4	2	4
18	R:R:F181	9.4675	4	0	5
19	R:R:F185	5.734	5	5	8
20	R:R:K198	4.8425	4	0	4
21	R:R:Y233	8.32333	6	5	9
22	R:R:R240	7.3925	4	2	5
23	R:R:F243	4.9075	4	2	4
24	R:R:L260	5.465	4	2	4
25	R:R:H261	10.1575	4	2	5
26	R:R:Y268	3.5925	4	0	7
27	R:R:M272	4.8325	4	4	8
28	R:R:D274	5.998	5	1	9
29	R:R:Y278	5.56875	8	1	9
30	R:R:Y279	6.09	6	1	7
31	R:R:F285	5.64	4	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E166	R:R:I169	10.9529	4.1	Yes	Yes	2	4	4
2	R:R:M18	R:R:Y75	28.4937	15.57	Yes	No	0	5	5
3	R:R:E166	R:R:Y74	10.0195	11.22	Yes	Yes	2	4	5
4	R:R:R71	R:R:Y74	19.6897	9.26	Yes	Yes	0	6	5
5	R:R:L95	R:R:R71	54.993	3.64	No	Yes	0	6	6
6	R:R:L95	R:R:Y268	56.8263	3.52	No	Yes	0	6	7
7	R:R:M18	R:R:S265	14.1226	3.07	Yes	No	0	5	5
8	R:R:L21	R:R:S265	12.6587	3	No	No	0	4	5
9	R:R:L21	R:R:M269	11.1275	2.83	No	No	0	4	4
10	R:R:T267	R:R:Y268	61.9099	4.99	No	Yes	0	8	7
11	R:R:T267	R:R:Y233	62.615	7.49	No	Yes	0	8	9
12	R:R:N270	R:R:Y233	100	5.81	No	Yes	0	9	9
13	R:R:D274	R:R:N270	98.4554	4.04	Yes	No	0	9	9
14	R:R:D274	R:R:D61	29.3667	7.98	Yes	Yes	1	9	9
15	R:R:D61	R:R:N33	14.3644	5.39	Yes	No	0	9	9
16	R:R:I169	R:R:L260	24.5047	11.42	Yes	Yes	2	4	4
17	R:R:L260	R:R:R240	24.5114	3.64	Yes	Yes	2	4	5
18	R:R:F181	R:R:R240	42.3544	4.28	Yes	Yes	0	5	5
19	R:R:F181	R:R:R99	46.5382	11.76	Yes	No	0	5	8
20	R:R:R99	R:R:Y233	42.4015	12.35	No	Yes	0	8	9
21	R:R:F62	R:R:N33	10.2277	6.04	No	No	0	7	9
22	R:R:D274	R:R:Y278	76.6167	5.75	Yes	Yes	1	9	9
23	R:R:L54	R:R:Y278	64.1461	3.52	No	Yes	1	8	9
24	R:R:F40	R:R:L54	68.8201	4.87	Yes	No	1	7	8
25	R:R:F40	R:R:Y279	19.1458	7.22	Yes	Yes	1	7	7
26	R:R:F40	R:R:F55	47.747	7.5	Yes	Yes	0	7	6
27	R:R:F285	R:R:F40	10.2142	5.36	Yes	Yes	1	9	7
28	R:R:F55	R:R:W47	36.8612	15.03	Yes	No	0	6	6
29	R:R:V52	R:R:W47	32.6506	2.45	No	No	0	7	6
30	R:R:A132	R:R:V52	31.2605	5.09	No	No	0	8	7
31	R:R:A132	R:R:P49	29.7159	3.74	No	Yes	0	8	7
32	R:R:P49	R:R:Y53	17.0841	4.17	Yes	No	0	7	7
33	R:R:D112	R:R:Y53	13.7331	8.05	No	No	0	8	7
34	R:R:F55	R:R:V59	13.9816	5.24	Yes	No	0	6	5
35	R:R:V59	R:R:W140	12.3229	2.45	No	Yes	0	5	9
36	R:R:D61	R:R:S271	25.7538	10.31	Yes	No	0	9	9
37	R:R:L64	R:R:S271	24.0011	4.5	No	No	0	7	9
38	R:R:L64	R:R:N98	22.2349	5.49	No	No	0	7	8
39	R:R:L92	R:R:R71	17.4065	3.64	No	Yes	0	6	6
40	R:R:W81	R:R:Y74	13.0011	3.86	No	Yes	0	8	5
41	R:R:C165	R:R:C88	14.2569	7.28	No	No	0	9	9
42	R:R:C165	R:R:L156	12.7258	4.76	No	No	0	9	5
43	R:R:M97	R:R:N98	18.6623	7.01	Yes	No	0	6	8
44	R:R:I103	R:R:Y233	31.4955	10.88	No	Yes	0	8	9
45	R:R:I103	R:R:P188	34.5309	3.39	No	No	0	8	9
46	R:R:P188	R:R:T107	31.106	3.5	No	No	0	9	7
47	R:R:I191	R:R:T107	29.3734	6.08	No	No	0	6	7
48	R:R:R113	R:R:Y278	25.0554	8.23	No	Yes	1	9	9
49	R:R:D112	R:R:K116	10.5097	9.68	No	No	0	8	8
50	R:R:I222	R:R:R113	28.6818	5.01	No	No	0	7	9
51	R:R:C195	R:R:I191	27.6274	1.64	No	No	0	8	6
52	R:R:C195	R:R:Y114	24.0951	4.03	No	Yes	0	8	9
53	R:R:I199	R:R:I222	22.8259	4.42	No	No	0	8	7
54	R:R:I199	R:R:V117	20.9791	7.68	No	No	0	8	8
55	R:R:L203	R:R:V117	18.9175	4.47	No	No	0	8	8
56	R:R:F168	R:R:F181	10.3955	17.15	No	Yes	0	4	5
57	R:R:F185	R:R:Y233	15.9492	6.19	Yes	Yes	5	8	9
58	R:R:F185	R:R:L234	11.3961	3.65	Yes	No	0	8	5
59	R:R:L203	R:R:M215	10.55	7.07	No	No	0	8	7
60	R:R:A239	R:R:L260	11.5573	3.15	No	Yes	0	4	4
61	R:R:F243	R:R:V256	14.5524	3.93	Yes	No	0	4	3
62	R:R:R71	R:R:Y75	27.1842	6.17	Yes	No	0	6	5
63	R:R:C88	R:R:L92	13.1556	3.17	No	No	0	9	6
64	R:R:F243	R:R:R240	14.2502	8.55	Yes	Yes	2	4	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8Z8B_nogp

PDB Summary
PDB	8Z8B_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.17
Number of Linked Nodes	258
Number of Links	278
Number of Hubs	31
Number of Links mediated by Hubs	114
Number of Communities	7
Number of Nodes involved in Communities	37
Number of Links involved in Communities	48

Path Summary
Number Of Nodes in MetaPath	65
Number Of Links MetaPath	64
Number of Shortest Paths	32602
Length Of Smallest Path	3
Average Path Length	12.5197
Length of Longest Path	31
Minimum Path Strength	1.165
Average Path Strength	6.02278
Maximum Path Strength	16.05
Minimum Path Correlation	0.7
Average Path Correlation	0.92261
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	50.4598
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	38.9707
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • negative regulation of catabolic process • lipid catabolic process • catabolic process • regulation of lipid metabolic process • negative regulation of metabolic process • negative regulation of biological process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • negative regulation of cellular process • metabolic process • regulation of metabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process • lipid metabolic process • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cell periphery • cellular anatomical structure • plasma membrane • membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • multicellular organismal process • system process • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • cell projection • sperm principal piece • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • plasma membrane bounded cell projection • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9BXC0
Sequence	>8Z8B_nogp_Chain_R C C R I E G D T I S Q V M P P L L I V A F V L G A L G N G V A L C G F C F H M K T W K P S T V Y L F N L A V A D F L L M I C L P F R T D Y Y L R R R H W A F G D I P C R V G L F T L A M N R A G S I V F L T V V A A D R Y F K V V H P H H A V N T I S T R V A A G I V C T L W A L V I L G T V Y L L L E N H L C V Q E T A V S C E S F I M E S A N G W H D I M F Q L E F F M P L G I I L F C S F K I V W S L R R R Q Q L A R Q A R M K K A T R F I M V V A I V F I T C Y L P S V S A R L Y F L W T V P S S A C D P S V H G A L H I T L S F T Y M N S M L D P L V Y Y F S S P S F P Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9IZD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	CHBA	-	Gi1/β1/γ2	3.16	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9IZD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	CHBA	-		3.16	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9J8Z	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	-	-	Gi1/β1/γ2	3.36	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9J8Z (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	-	-		3.36	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	8Z8A	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	Lactate	-	Gi1/β1/γ2	2.82	2025-10-29	To be published
	8Z8A (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	Lactate	-		2.82	2025-10-29	To be published
	8Z8B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	-	-	Gi1/β1/γ2	2.65	2025-10-29	To be published
	8Z8B (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	-	-		2.65	2025-10-29	To be published
	8Z87	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	CHBA	-	Gi1/β1/γ2	2.73	2025-11-05	To be published
	8Z87 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	CHBA	-		2.73	2025-11-05	To be published
	9KT9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	3,5-DHBA	-	Gi1/β1/γ2	2.7	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	3,5-DHBA	-		2.7	2025-12-10	10.1021/acs.jmedchem.4c02567

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8Z8B_nogp.zip

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