psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C157	R:R:C6	7.28	No	No	1	3	6
2	R:R:C6	R:R:Q159	10.68	No	No	0	6	3
3	R:R:C252	R:R:C7	7.28	No	No	0	7	6
4	R:R:E10	R:R:R8	13.96	No	No	0	4	2
5	R:R:Q159	R:R:R8	3.5	No	No	0	3	2
6	R:R:I9	R:R:R79	8.77	Yes	Yes	1	4	5
7	R:R:C252	R:R:I9	3.27	No	Yes	1	7	4
8	R:R:H257	R:R:I9	13.26	No	Yes	1	4	4
9	R:R:Q16	R:R:T13	4.25	No	No	0	3	3
10	R:R:G258	R:R:I14	3.53	No	No	0	1	4
11	R:R:H261	R:R:I14	3.98	No	No	0	5	4
12	R:R:R78	R:R:S15	5.27	No	No	0	3	5
13	R:R:M18	R:R:V17	3.04	Yes	No	0	5	5
14	R:R:L22	R:R:M18	2.83	No	Yes	0	7	5
15	R:R:M18	R:R:Y75	9.58	Yes	Yes	0	5	5
16	R:R:I262	R:R:M18	2.92	No	Yes	0	5	5
17	R:R:P19	R:R:P20	5.84	No	No	0	6	4
18	R:R:L76	R:R:P19	8.21	No	No	0	3	6
19	R:R:L21	R:R:S265	9.01	No	No	0	4	5
20	R:R:L22	R:R:T72	4.42	No	No	0	7	7
21	R:R:I23	R:R:T72	4.56	No	No	0	5	7
22	R:R:F26	R:R:P69	11.56	No	No	0	7	9
23	R:R:L28	R:R:M272	2.83	No	Yes	0	5	8
24	R:R:G29	R:R:M272	3.49	No	Yes	0	8	8
25	R:R:F280	R:R:G32	3.01	Yes	No	0	7	7
26	R:R:D61	R:R:N33	8.08	Yes	No	0	9	9
27	R:R:N33	R:R:P275	8.15	No	No	0	9	9
28	R:R:A36	R:R:F40	2.77	No	Yes	0	8	7
29	R:R:F55	R:R:L37	3.65	Yes	No	0	6	8
30	R:R:G39	R:R:H43	6.35	No	No	0	8	5
31	R:R:F40	R:R:M44	3.73	Yes	No	0	7	6
32	R:R:F40	R:R:F55	3.22	Yes	Yes	0	7	6
33	R:R:A58	R:R:F40	2.77	No	Yes	0	8	7
34	R:R:F40	R:R:Y279	6.19	Yes	Yes	3	7	7
35	R:R:F285	R:R:F40	3.22	Yes	Yes	3	9	7
36	R:R:C41	R:R:F42	6.98	No	No	0	4	4
37	R:R:H43	R:R:P286	3.05	No	Yes	0	5	8
38	R:R:M44	R:R:P286	3.35	No	Yes	0	6	8
39	R:R:T51	R:R:W47	3.64	No	No	0	8	6
40	R:R:D112	R:R:S50	4.42	No	No	0	8	7
41	R:R:N56	R:R:V52	4.43	Yes	No	5	9	7
42	R:R:V136	R:R:V52	4.81	No	No	5	7	7
43	R:R:V108	R:R:Y53	8.83	No	No	0	6	7
44	R:R:D112	R:R:Y53	6.9	No	No	0	8	7
45	R:R:A132	R:R:Y53	4	No	No	0	8	7
46	R:R:L54	R:R:V109	4.47	No	No	0	8	9
47	R:R:L54	R:R:Y278	3.52	No	Yes	0	8	9
48	R:R:F55	R:R:N56	3.62	Yes	Yes	0	6	9
49	R:R:F55	R:R:V59	7.87	Yes	No	0	6	5
50	R:R:F105	R:R:N56	9.67	Yes	Yes	0	7	9
51	R:R:N56	R:R:V136	8.87	Yes	No	5	9	7
52	R:R:D61	R:R:L57	5.43	Yes	Yes	4	9	9
53	R:R:F105	R:R:L57	3.65	Yes	Yes	0	7	9
54	R:R:L106	R:R:L57	2.77	No	Yes	0	8	9
55	R:R:D274	R:R:L57	6.79	Yes	Yes	4	9	9
56	R:R:D61	R:R:S102	4.42	Yes	No	0	9	9
57	R:R:D61	R:R:S271	11.78	Yes	No	0	9	9
58	R:R:D274	R:R:D61	5.32	Yes	Yes	4	9	9
59	R:R:F62	R:R:I66	7.54	No	No	0	7	5
60	R:R:L63	R:R:N98	10.98	No	Yes	0	7	8
61	R:R:L64	R:R:N98	2.75	No	Yes	0	7	8
62	R:R:L64	R:R:S271	6.01	No	No	0	7	9
63	R:R:C67	R:R:F70	2.79	No	No	0	6	6
64	R:R:C67	R:R:T94	6.76	No	No	0	6	4
65	R:R:C67	R:R:L95	3.17	No	No	0	6	6
66	R:R:L68	R:R:P69	3.28	No	No	0	8	9
67	R:R:R71	R:R:Y74	6.17	No	Yes	1	6	5
68	R:R:R71	R:R:Y75	11.32	No	Yes	1	6	5
69	L:L:?1	R:R:R71	13.08	Yes	No	1	0	6
70	R:R:D73	R:R:R77	10.72	No	No	0	3	4
71	R:R:Y74	R:R:Y75	8.94	Yes	Yes	1	5	5
72	R:R:R79	R:R:Y74	5.14	Yes	Yes	1	5	5
73	R:R:W81	R:R:Y74	7.72	No	Yes	0	8	5
74	R:R:E166	R:R:Y74	3.37	Yes	Yes	1	4	5
75	R:R:R79	R:R:Y75	4.12	Yes	Yes	1	5	5
76	R:R:H261	R:R:Y75	9.8	No	Yes	0	5	5
77	L:L:?1	R:R:Y75	3.71	Yes	Yes	1	0	5
78	R:R:H80	R:R:R77	4.51	Yes	No	6	5	4
79	R:R:A82	R:R:R77	4.15	No	No	6	3	4
80	R:R:R78	R:R:R79	4.26	No	Yes	0	3	5
81	R:R:E166	R:R:R79	4.65	Yes	Yes	1	4	5
82	R:R:A82	R:R:H80	2.93	No	Yes	6	3	5
83	R:R:A162	R:R:H80	5.85	No	Yes	0	3	5
84	R:R:H80	R:R:V163	4.15	Yes	No	0	5	5
85	R:R:C88	R:R:W81	10.45	Yes	No	0	9	8
86	R:R:G84	R:R:P87	6.09	No	No	0	8	6
87	R:R:D85	R:R:L156	8.14	No	Yes	0	3	5
88	R:R:I86	R:R:P87	3.39	No	No	0	3	6
89	R:R:C88	R:R:L92	4.76	Yes	No	0	9	6
90	R:R:C88	R:R:L156	3.17	Yes	Yes	7	9	5
91	R:R:C165	R:R:C88	7.28	No	Yes	7	9	9
92	R:R:H155	R:R:L92	3.86	No	No	0	4	6
93	R:R:F93	R:R:M97	4.98	Yes	Yes	0	5	6
94	R:R:F93	R:R:T147	5.19	Yes	No	1	5	6
95	R:R:F93	R:R:L150	3.65	Yes	Yes	1	5	5
96	R:R:F93	R:R:L151	15.83	Yes	No	0	5	5
97	R:R:N98	R:R:T94	7.31	Yes	No	0	8	4
98	R:R:L95	R:R:Y268	5.86	No	No	1	6	7
99	L:L:?1	R:R:L95	11.4	Yes	No	1	0	6
100	R:R:A96	R:R:L150	3.15	No	Yes	0	5	5
101	R:R:M97	R:R:N98	8.41	Yes	Yes	0	6	8
102	R:R:M97	R:R:W140	3.49	Yes	No	0	6	9
103	R:R:I144	R:R:M97	5.83	No	Yes	0	4	6
104	R:R:I103	R:R:R99	5.01	Yes	Yes	1	8	8
105	R:R:F181	R:R:R99	11.76	No	Yes	0	5	8
106	R:R:E184	R:R:R99	9.3	Yes	Yes	1	5	8
107	R:R:R99	R:R:Y233	5.14	Yes	Yes	1	8	9
108	R:R:R99	R:R:T267	3.88	Yes	Yes	1	8	8
109	R:R:A100	R:R:E184	3.02	No	Yes	0	6	5
110	R:R:G101	R:R:V143	3.68	No	No	0	7	7
111	R:R:E184	R:R:I103	5.47	Yes	Yes	1	5	8
112	R:R:I103	R:R:P188	3.39	Yes	No	0	8	9
113	R:R:I103	R:R:Y233	8.46	Yes	Yes	1	8	9
114	R:R:L139	R:R:V104	5.96	No	No	0	7	6
115	R:R:F105	R:R:W140	4.01	Yes	No	0	7	9
116	R:R:L106	R:R:Y278	3.52	No	Yes	0	8	9
117	R:R:P188	R:R:T107	3.5	No	No	0	9	7
118	R:R:I191	R:R:T107	4.56	No	No	0	6	7
119	R:R:R113	R:R:V109	3.92	No	No	0	9	9
120	R:R:D112	R:R:K116	8.3	No	No	0	8	8
121	R:R:R113	R:R:Y278	4.12	No	Yes	0	9	9
122	R:R:F115	R:R:Y114	3.09	Yes	Yes	2	5	9
123	R:R:V118	R:R:Y114	10.09	No	Yes	2	7	9
124	R:R:H119	R:R:Y114	4.36	Yes	Yes	2	7	9
125	R:R:F194	R:R:Y114	6.19	No	Yes	2	5	9
126	R:R:C195	R:R:Y114	9.41	No	Yes	0	8	9
127	R:R:K198	R:R:Y114	7.17	No	Yes	2	4	9
128	R:R:I199	R:R:Y114	3.63	No	Yes	0	8	9
129	R:R:F115	R:R:H119	3.39	Yes	Yes	2	5	7
130	R:R:F115	R:R:H122	4.53	Yes	Yes	2	5	4
131	R:R:F115	R:R:V124	6.55	Yes	No	2	5	5
132	R:R:K116	R:R:N125	9.79	No	No	0	8	3
133	R:R:I199	R:R:V117	6.14	No	No	0	8	8
134	R:R:L203	R:R:V117	2.98	No	No	0	8	8
135	R:R:H119	R:R:V118	8.3	Yes	No	2	7	7
136	R:R:S202	R:R:V118	6.46	No	No	0	5	7
137	R:R:H119	R:R:H122	5.97	Yes	Yes	2	7	4
138	R:R:H121	R:R:P120	6.1	No	No	0	6	7
139	R:R:H122	R:R:V124	8.3	Yes	No	2	4	5
140	R:R:N125	R:R:V124	4.43	No	No	0	3	5
141	R:R:I127	R:R:V131	6.14	No	No	0	7	4
142	R:R:S128	R:R:V131	3.23	No	No	0	6	4
143	R:R:I135	R:R:L139	2.85	No	No	0	6	7
144	R:R:L150	R:R:T147	4.42	Yes	No	1	5	6
145	R:R:L150	R:R:Y149	8.21	Yes	Yes	1	5	7
146	R:R:E153	R:R:Y149	5.61	No	Yes	0	4	7
147	R:R:W176	R:R:Y149	32.8	No	Yes	1	5	7
148	R:R:H177	R:R:Y149	15.24	No	Yes	1	5	7
149	R:R:M180	R:R:Y149	3.59	No	Yes	1	4	7
150	R:R:H177	R:R:L150	9	No	Yes	1	5	5
151	R:R:E153	R:R:H155	11.08	No	No	0	4	4
152	R:R:L156	R:R:N154	2.75	Yes	No	0	5	4
153	R:R:H155	R:R:S167	4.18	No	No	0	4	4
154	R:R:L156	R:R:V163	2.98	Yes	No	0	5	5
155	R:R:C165	R:R:L156	6.35	No	Yes	7	9	5
156	R:R:V158	R:R:V163	4.81	No	No	0	1	5
157	R:R:E166	R:R:I169	2.73	Yes	No	0	4	4
158	R:R:E166	R:R:H261	3.69	Yes	No	0	4	5
159	R:R:H177	R:R:S167	8.37	No	No	0	5	4
160	R:R:F168	R:R:F181	11.79	No	No	0	4	5
161	R:R:F168	R:R:R240	8.55	No	No	0	4	5
162	R:R:I169	R:R:M170	4.37	No	No	0	4	3
163	R:R:E171	R:R:M170	6.77	No	No	0	1	3
164	R:R:G175	R:R:I179	3.53	No	No	0	3	4
165	R:R:M180	R:R:W176	4.65	No	No	1	4	5
166	R:R:D178	R:R:Q182	5.22	No	Yes	0	4	5
167	R:R:D178	R:R:R240	3.57	No	No	0	4	5
168	R:R:D178	R:R:L244	6.79	No	No	0	4	5
169	R:R:E184	R:R:M180	5.41	Yes	No	1	5	4
170	R:R:F186	R:R:Q182	3.51	No	Yes	0	5	5
171	R:R:Q182	R:R:V237	4.3	Yes	No	0	5	8
172	R:R:L241	R:R:Q182	5.32	No	Yes	0	5	5
173	R:R:F185	R:R:F186	11.79	No	No	0	8	5
174	R:R:F185	R:R:Y233	3.09	No	Yes	0	8	9
175	R:R:F185	R:R:V237	11.8	No	No	0	8	8
176	R:R:L189	R:R:L193	6.92	Yes	No	8	6	4
177	R:R:F229	R:R:L189	4.87	No	Yes	0	9	6
178	R:R:I230	R:R:L189	5.71	No	Yes	0	6	6
179	R:R:F194	R:R:K198	13.65	No	No	2	5	4
180	R:R:I222	R:R:S196	3.1	No	No	0	7	8
181	R:R:F197	R:R:K198	3.72	No	No	0	1	4
182	R:R:F197	R:R:W201	6.01	No	No	0	1	3
183	R:R:R204	R:R:V200	6.54	No	No	0	4	5
184	R:R:I222	R:R:V200	3.07	No	No	0	7	5
185	R:R:L203	R:R:M215	4.24	No	No	0	8	7
186	R:R:L203	R:R:T219	4.42	No	No	0	8	6
187	R:R:R205	R:R:R206	3.2	No	No	0	4	5
188	R:R:L209	R:R:R206	7.29	No	No	0	2	5
189	R:R:Q212	R:R:R214	10.51	No	No	0	3	4
190	R:R:F221	R:R:K217	8.69	No	No	0	8	7
191	R:R:K217	R:R:P283	3.35	No	No	0	7	5
192	R:R:F221	R:R:S281	7.93	No	No	0	8	7
193	R:R:V225	R:R:Y278	5.05	No	Yes	0	8	9
194	R:R:L273	R:R:V228	2.98	No	No	0	7	7
195	R:R:F229	R:R:Y233	3.09	No	Yes	0	9	9
196	R:R:C232	R:R:N270	3.15	No	No	0	9	9
197	R:R:T267	R:R:Y233	8.74	Yes	Yes	1	8	9
198	R:R:N270	R:R:Y233	13.96	No	Yes	0	9	9
199	R:R:L234	R:R:P235	3.28	No	No	0	5	9
200	R:R:P235	R:R:T263	3.5	No	No	0	9	7
201	R:R:S236	R:R:T263	6.4	No	No	0	6	7
202	R:R:L264	R:R:S236	3	No	No	1	6	6
203	R:R:S236	R:R:T267	4.8	No	Yes	1	6	8
204	R:R:A239	R:R:L260	3.15	No	No	0	4	4
205	R:R:A239	R:R:T263	3.36	No	No	0	4	7
206	R:R:T246	R:R:Y242	3.75	No	No	0	3	4
207	R:R:F243	R:R:S250	6.61	Yes	No	9	4	2
208	R:R:F243	R:R:V256	5.24	Yes	No	9	4	3
209	R:R:P248	R:R:V247	3.53	No	No	0	1	3
210	R:R:S250	R:R:V256	4.85	No	No	9	2	3
211	R:R:C252	R:R:H257	4.42	No	No	1	7	4
212	R:R:D253	R:R:P254	9.66	No	No	0	2	2
213	R:R:D253	R:R:S255	4.42	No	No	0	2	4
214	R:R:D253	R:R:V256	5.84	No	No	0	2	3
215	R:R:F266	R:R:I262	3.77	No	No	0	7	5
216	R:R:L264	R:R:T267	2.95	No	Yes	1	6	8
217	L:L:?1	R:R:L264	5.26	Yes	No	1	0	6
218	L:L:?1	R:R:Y268	5.2	Yes	No	1	0	7
219	R:R:M269	R:R:M272	11.55	No	Yes	0	4	8
220	R:R:L273	R:R:M269	2.83	No	No	0	7	4
221	R:R:D274	R:R:N270	9.42	Yes	No	0	9	9
222	R:R:D274	R:R:Y278	5.75	Yes	Yes	0	9	9
223	R:R:F280	R:R:L276	4.87	Yes	No	0	7	6
224	R:R:F285	R:R:Y279	10.32	Yes	Yes	3	9	7
225	R:R:P286	R:R:Y279	8.34	Yes	Yes	3	8	7
226	R:R:F280	R:R:F288	3.22	Yes	No	0	7	4
227	R:R:P283	R:R:S282	3.56	No	No	0	5	8
228	R:R:F285	R:R:S282	10.57	Yes	No	0	9	8
229	R:R:F285	R:R:P286	4.33	Yes	Yes	3	9	8
230	R:R:D73	R:R:L76	2.71	No	No	0	3	3
231	R:R:R205	R:R:S202	2.64	No	No	0	4	5
232	R:R:F105	R:R:V108	2.62	Yes	No	0	7	6
233	R:R:F243	R:R:V247	2.62	Yes	No	0	4	3
234	R:R:A60	R:R:W140	2.59	No	No	0	8	9
235	R:R:V277	R:R:Y278	2.52	No	Yes	0	8	9
236	R:R:I222	R:R:R113	2.51	No	No	0	7	9
237	R:R:F229	R:R:I192	2.51	No	No	0	9	8
238	R:R:F243	R:R:M170	2.49	Yes	No	0	4	3
239	R:R:F62	R:R:N33	2.42	No	No	0	7	9
240	R:R:Q208	R:R:R211	2.34	No	No	0	3	3
241	R:R:F42	R:R:H43	2.26	No	No	0	4	5
242	R:R:F280	R:R:Y279	2.06	Yes	Yes	0	7	7
243	R:R:C38	R:R:G39	1.96	No	No	0	4	8
244	R:R:C137	R:R:G134	1.96	No	No	0	5	2
245	R:R:P235	R:R:S238	1.78	No	No	0	9	6
246	R:R:G11	R:R:I9	1.76	No	Yes	0	4	4
247	R:R:G29	R:R:M65	1.75	No	No	0	8	6
248	R:R:P49	R:R:T129	1.75	No	No	0	7	3
249	R:R:P69	R:R:T72	1.75	No	No	0	9	7
250	R:R:C6	R:R:S164	1.72	No	No	1	6	4
251	R:R:C157	R:R:S164	1.72	No	No	1	3	4
252	R:R:G32	R:R:L31	1.71	No	No	0	7	4
253	R:R:C137	R:R:V136	1.71	No	No	0	5	7
254	R:R:G190	R:R:L189	1.71	No	Yes	8	3	6
255	R:R:G190	R:R:L193	1.71	No	No	8	3	4
256	R:R:A226	R:R:S196	1.71	No	No	0	7	8
257	R:R:C232	R:R:V228	1.71	No	No	0	9	7
258	R:R:G175	R:R:N174	1.7	No	No	0	3	3
259	R:R:I127	R:R:P49	1.69	No	No	0	7	7
260	R:R:C232	R:R:T231	1.69	No	No	0	9	6
261	R:R:D12	R:R:G11	1.68	No	No	0	4	4
262	R:R:A162	R:R:T161	1.68	No	No	0	3	5
263	R:R:M187	R:R:P188	1.68	No	No	0	5	9
264	R:R:K48	R:R:P49	1.67	No	No	0	7	7
265	R:R:S282	R:R:S284	1.63	No	No	0	8	6
266	R:R:A110	R:R:I192	1.62	No	No	0	9	8
267	R:R:A132	R:R:I127	1.62	No	No	0	8	7
268	R:R:A25	R:R:M272	1.61	No	Yes	0	7	8
269	R:R:S50	R:R:T51	1.6	No	No	0	7	8
270	R:R:V104	R:R:V108	1.6	No	No	0	6	6
271	R:R:V104	R:R:V143	1.6	No	No	0	6	7
272	R:R:V224	R:R:V228	1.6	No	No	0	6	7
273	R:R:V224	R:R:V277	1.6	No	No	0	6	8
274	R:R:S249	R:R:T246	1.6	No	No	0	1	3
275	R:R:T13	R:R:V17	1.59	No	No	0	3	5
276	R:R:H119	R:R:P120	1.53	Yes	No	0	7	7
277	R:R:M223	R:R:S196	1.53	No	No	0	5	8
278	R:R:K45	R:R:T46	1.5	No	No	0	6	6
279	R:R:L244	R:R:S172	1.5	No	No	0	5	1
280	R:R:K216	R:R:T219	1.5	No	No	0	4	6
281	R:R:L21	R:R:V17	1.49	No	No	0	4	5
282	R:R:L28	R:R:V24	1.49	No	No	0	5	5
283	R:R:L28	R:R:V27	1.49	No	No	0	5	6
284	R:R:L151	R:R:V90	1.49	No	No	0	5	5
285	R:R:A123	R:R:H122	1.46	No	Yes	0	5	4
286	R:R:N125	R:R:T126	1.46	No	No	0	3	4
287	R:R:I179	R:R:L183	1.43	No	No	0	4	4
288	R:R:G84	R:R:W81	1.41	No	No	0	8	8
289	R:R:L183	R:R:M187	1.41	No	No	0	4	5
290	R:R:R130	R:R:S128	1.32	No	No	0	4	6
291	R:R:F288	R:R:V35	1.31	No	No	0	4	5
292	R:R:S164	R:R:Y74	1.27	No	Yes	1	4	5
293	R:R:I86	R:R:R89	1.25	No	No	0	3	6
294	R:R:T246	R:R:W245	1.21	No	No	0	3	4
295	R:R:F221	R:R:R220	1.07	No	No	0	8	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I9	6.765	4	1	4
2	R:R:M18	4.5925	4	0	5
3	R:R:F40	3.65	6	3	7
4	R:R:F55	4.59	4	0	6
5	R:R:N56	6.6475	4	5	9
6	R:R:L57	4.66	4	4	9
7	R:R:D61	7.006	5	4	9
8	R:R:Y74	5.435	6	1	5
9	R:R:Y75	7.91167	6	1	5
10	R:R:R79	5.388	5	1	5
11	R:R:H80	4.36	4	6	5
12	R:R:C88	6.415	4	7	9
13	R:R:F93	7.4125	4	1	5
14	R:R:M97	5.6775	4	0	6
15	R:R:N98	7.3625	4	0	8
16	R:R:R99	7.018	5	1	8
17	R:R:I103	5.5825	4	1	8
18	R:R:F105	4.9875	4	0	7
19	R:R:Y114	6.27714	7	2	9
20	R:R:F115	4.39	4	2	5
21	R:R:H119	4.71	5	2	7
22	R:R:H122	5.065	4	2	4
23	R:R:Y149	13.09	5	1	7
24	R:R:L150	5.686	5	1	5
25	R:R:L156	4.678	5	7	5
26	R:R:E166	3.61	4	1	4
27	R:R:Q182	4.5875	4	0	5
28	R:R:E184	5.8	4	1	5
29	R:R:L189	4.8025	4	8	6
30	R:R:Y233	7.08	6	1	9
31	R:R:F243	4.24	4	9	4
32	R:R:T267	5.0925	4	1	8
33	R:R:M272	4.87	4	0	8
34	R:R:D274	6.82	4	4	9
35	R:R:Y278	4.08	6	0	9
36	R:R:Y279	6.7275	4	3	7
37	R:R:F280	3.29	4	0	7
38	R:R:F285	7.11	4	3	9
39	R:R:P286	4.7675	4	3	8
40	L:L:?1	7.73	5	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S164	R:R:Y74	17.2109	1.27	No	Yes	1	4	5
2	R:R:Y74	R:R:Y75	38.9454	8.94	Yes	Yes	1	5	5
3	R:R:M18	R:R:Y75	22.9058	9.58	Yes	Yes	0	5	5
4	R:R:H261	R:R:Y75	20.1333	9.8	No	Yes	0	5	5
5	R:R:E166	R:R:Y74	33.4674	3.37	Yes	Yes	1	4	5
6	R:R:E166	R:R:H261	16.3472	3.69	Yes	No	0	4	5
7	R:R:L22	R:R:M18	10.0528	2.83	No	Yes	0	7	5
8	R:R:W81	R:R:Y74	30.2453	7.72	No	Yes	0	8	5
9	R:R:C88	R:R:W81	21.7661	10.45	Yes	No	0	9	8
10	R:R:C88	R:R:L156	27.1612	3.17	Yes	Yes	7	9	5
11	R:R:L156	R:R:V163	21.5136	2.98	Yes	No	0	5	5
12	R:R:H80	R:R:V163	17.6723	4.15	Yes	No	0	5	5
13	R:R:R71	R:R:Y74	35.8101	6.17	No	Yes	1	6	5
14	L:L:?1	R:R:R71	36.6935	13.08	Yes	No	1	0	6
15	L:L:?1	R:R:L264	90.1443	5.26	Yes	No	1	0	6
16	R:R:L264	R:R:T267	86.4214	2.95	No	Yes	1	6	8
17	R:R:T267	R:R:Y233	82.1738	8.74	Yes	Yes	1	8	9
18	R:R:N270	R:R:Y233	90.1641	13.96	No	Yes	0	9	9
19	R:R:C232	R:R:N270	16.6746	3.15	No	No	0	9	9
20	R:R:C232	R:R:V228	14.0322	1.71	No	No	0	9	7
21	R:R:L273	R:R:V228	12.4546	2.98	No	No	0	7	7
22	R:R:L273	R:R:M269	11.1019	2.83	No	No	0	7	4
23	L:L:?1	R:R:Y75	100	3.71	Yes	Yes	1	0	5
24	L:L:?1	R:R:L95	49.8896	11.4	Yes	No	1	0	6
25	R:R:C67	R:R:L95	50.0158	3.17	No	No	0	6	6
26	R:R:C67	R:R:T94	49.5583	6.76	No	No	0	6	4
27	R:R:N98	R:R:T94	49.4518	7.31	Yes	No	0	8	4
28	R:R:M97	R:R:N98	49.3453	8.41	Yes	Yes	0	6	8
29	R:R:M97	R:R:W140	72.8506	3.49	Yes	No	0	6	9
30	R:R:F105	R:R:W140	73.1188	4.01	Yes	No	0	7	9
31	R:R:F105	R:R:N56	75.1301	9.67	Yes	Yes	0	7	9
32	R:R:F55	R:R:N56	67.4199	3.62	Yes	Yes	0	6	9
33	R:R:F40	R:R:F55	62.8333	3.22	Yes	Yes	0	7	6
34	R:R:F40	R:R:Y279	22.1289	6.19	Yes	Yes	3	7	7
35	R:R:F280	R:R:Y279	10.4236	2.06	Yes	Yes	0	7	7
36	R:R:D274	R:R:N270	85.4275	9.42	Yes	No	0	9	9
37	R:R:D274	R:R:L57	75.067	6.79	Yes	Yes	4	9	9
38	R:R:F105	R:R:L57	84.69	3.65	Yes	Yes	0	7	9
39	R:R:F40	R:R:M44	12.08	3.73	Yes	No	0	7	6
40	R:R:M44	R:R:P286	10.3486	3.35	No	Yes	0	6	8
41	R:R:H43	R:R:P286	26.4789	3.05	No	Yes	0	5	8
42	R:R:G39	R:R:H43	10.6129	6.35	No	No	0	8	5
43	R:R:P286	R:R:Y279	10.6405	8.34	Yes	Yes	3	8	7
44	R:R:F285	R:R:F40	24.0771	3.22	Yes	Yes	3	9	7
45	R:R:F285	R:R:P286	10.672	4.33	Yes	Yes	3	9	8
46	R:R:F42	R:R:H43	10.6129	2.26	No	No	0	4	5
47	R:R:F105	R:R:V108	95.8708	2.62	Yes	No	0	7	6
48	R:R:V108	R:R:Y53	87.2575	8.83	No	No	0	6	7
49	R:R:D112	R:R:Y53	73.7774	6.9	No	No	0	8	7
50	R:R:A132	R:R:Y53	14.7618	4	No	No	0	8	7
51	R:R:D274	R:R:Y278	17.4752	5.75	Yes	Yes	0	9	9
52	R:R:R113	R:R:Y278	14.0322	4.12	No	Yes	0	9	9
53	R:R:G84	R:R:W81	14.8722	1.41	No	No	0	8	8
54	R:R:G84	R:R:P87	11.165	6.09	No	No	0	8	6
55	R:R:C88	R:R:L92	24.6056	4.76	Yes	No	0	9	6
56	R:R:H155	R:R:L92	25.7454	3.86	No	No	0	4	6
57	R:R:F93	R:R:M97	29.3934	4.98	Yes	Yes	0	5	6
58	R:R:E153	R:R:H155	14.7578	11.08	No	No	0	4	4
59	R:R:E153	R:R:Y149	15.5032	5.61	No	Yes	0	4	7
60	R:R:L150	R:R:Y149	15.7083	8.21	Yes	Yes	1	5	7
61	R:R:F93	R:R:L150	27.2085	3.65	Yes	Yes	1	5	5
62	R:R:H155	R:R:S167	12.2496	4.18	No	No	0	4	4
63	R:R:H177	R:R:S167	12.8648	8.37	No	No	0	5	4
64	R:R:H177	R:R:L150	12.7583	9	No	Yes	1	5	5
65	R:R:R99	R:R:T267	10.2224	3.88	Yes	Yes	1	8	8
66	R:R:I103	R:R:Y233	13.3105	8.46	Yes	Yes	1	8	9
67	R:R:I103	R:R:P188	13.973	3.39	Yes	No	0	8	9
68	R:R:D112	R:R:K116	67.7354	8.3	No	No	0	8	8
69	R:R:K116	R:R:N125	66.1697	9.79	No	No	0	8	3
70	R:R:N125	R:R:V124	63.0147	4.43	No	No	0	3	5
71	R:R:F115	R:R:V124	44.2499	6.55	Yes	No	2	5	5
72	R:R:F115	R:R:Y114	28.9714	3.09	Yes	Yes	2	5	9
73	R:R:F115	R:R:H119	13.7324	3.39	Yes	Yes	2	5	7
74	R:R:H119	R:R:V118	17.1123	8.3	Yes	No	2	7	7
75	R:R:H122	R:R:V124	17.1715	8.3	Yes	No	2	4	5
76	R:R:H119	R:R:H122	13.8587	5.97	Yes	Yes	2	7	4
77	R:R:I199	R:R:Y114	10.5182	3.63	No	Yes	0	8	9
78	R:R:S202	R:R:V118	20.5987	6.46	No	No	0	5	7
79	R:R:A132	R:R:I127	12.9437	1.62	No	No	0	8	7
80	R:R:E166	R:R:I169	59.7847	2.73	Yes	No	0	4	4
81	R:R:I169	R:R:M170	55.0521	4.37	No	No	0	4	3
82	R:R:F185	R:R:Y233	16.6824	3.09	No	Yes	0	8	9
83	R:R:I222	R:R:R113	10.6799	2.51	No	No	0	7	9
84	R:R:R205	R:R:S202	15.8621	2.64	No	No	0	4	5
85	R:R:R205	R:R:R206	10.5813	3.2	No	No	0	4	5
86	R:R:F285	R:R:S282	12.4468	10.57	Yes	No	0	9	8
87	R:R:F243	R:R:M170	44.104	2.49	Yes	No	0	4	3
88	R:R:F243	R:R:V256	22.0973	5.24	Yes	No	9	4	3
89	R:R:F243	R:R:V247	11.0704	2.62	Yes	No	0	4	3
90	R:R:D253	R:R:V256	16.5957	5.84	No	No	0	2	3
91	R:R:C6	R:R:S164	11.5121	1.72	No	No	1	6	4
92	R:R:R79	R:R:Y75	27.8632	4.12	Yes	Yes	1	5	5
93	R:R:E166	R:R:R79	16.2131	4.65	Yes	Yes	1	4	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:M18	R:R:Y75	9.58	0	Yes	Yes	5	5	2	1
R:R:C67	R:R:L95	3.17	0	No	No	6	6	2	1
R:R:R71	R:R:Y74	6.17	1	No	Yes	6	5	1	2
R:R:R71	R:R:Y75	11.32	1	No	Yes	6	5	1	1
L:L:?1	R:R:R71	13.08	1	Yes	No	0	6	0	1
R:R:Y74	R:R:Y75	8.94	1	Yes	Yes	5	5	2	1
R:R:R79	R:R:Y74	5.14	1	Yes	Yes	5	5	2	2
R:R:R79	R:R:Y75	4.12	1	Yes	Yes	5	5	2	1
R:R:H261	R:R:Y75	9.8	0	No	Yes	5	5	2	1
L:L:?1	R:R:Y75	3.71	1	Yes	Yes	0	5	0	1
R:R:L95	R:R:Y268	5.86	1	No	No	6	7	1	1
L:L:?1	R:R:L95	11.4	1	Yes	No	0	6	0	1
R:R:L264	R:R:S236	3	1	No	No	6	6	1	2
R:R:S236	R:R:T267	4.8	1	No	Yes	6	8	2	2
R:R:L264	R:R:T267	2.95	1	No	Yes	6	8	1	2
L:L:?1	R:R:L264	5.26	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y268	5.2	1	Yes	No	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9KT9_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.73
Number of Linked Nodes	261
Number of Links	295
Number of Hubs	40
Number of Links mediated by Hubs	142
Number of Communities	9
Number of Nodes involved in Communities	58
Number of Links involved in Communities	76

Path Summary
Number Of Nodes in MetaPath	94
Number Of Links MetaPath	93
Number of Shortest Paths	68219
Length Of Smallest Path	3
Average Path Length	15.0582
Length of Longest Path	31
Minimum Path Strength	1.405
Average Path Strength	5.70048
Maximum Path Strength	20.505
Minimum Path Correlation	0.7
Average Path Correlation	0.928254
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	43.4896
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.4672
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • negative regulation of catabolic process • lipid catabolic process • catabolic process • regulation of lipid metabolic process • negative regulation of metabolic process • negative regulation of biological process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • negative regulation of cellular process • metabolic process • regulation of metabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process • lipid metabolic process • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	34D
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	34D
Name	3,5-DIHYDROXYBENZOATE
Synonyms
Identifier
Formula	C7 H6 O4
Molecular Weight	154.12
SMILES
PubChem	7424
Formal Charge	0
Total Atoms	17
Total Chiral Atoms	0
Total Bonds	17
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9BXC0
Sequence	>9KT9_nogp_Chain_R C C R I E G D T I S Q V M P P L L I V A F V L G A L G N G V A L C G F C F H M K T W K P S T V Y L F N L A V A D F L L M I C L P F R T D Y Y L R R R H W A F G D I P C R V G L F T L A M N R A G S I V F L T V V A A D R Y F K V V H P H H A V N T I S T R V A A G I V C T L W A L V I L G T V Y L L L E N H L C V Q E T A V S C E S F I M E S A N G W H D I M F Q L E F F M P L G I I L F C S F K I V W S L R R R Q Q L A R Q A R M K K A T R F I M V V A I V F I T C Y L P S V S A R L Y F L W T V P S S A C D P S V H G A L H I T L S F T Y M N S M L D P L V Y Y F S S P S F P K F Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9IZD	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	CHBA	-	Gi1/β1/γ2	3.16	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9IZD (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	CHBA	-		3.16	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9J8Z	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	-	-	Gi1/β1/γ2	3.36	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	9J8Z (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	-	-		3.36	2025-04-02	doi.org/10.1371/journal.pbio.3003126
	8Z8A	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	Lactate	-	Gi1/β1/γ2	2.82	2025-10-29	To be published
	8Z8A (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	Lactate	-		2.82	2025-10-29	To be published
	8Z8B	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	-	-	Gi1/β1/γ2	2.65	2025-10-29	To be published
	8Z8B (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	-	-		2.65	2025-10-29	To be published
	8Z87	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	CHBA	-	Gi1/β1/γ2	2.73	2025-11-05	To be published
	8Z87 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	CHBA	-		2.73	2025-11-05	To be published
	9KT9	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	3,5-DHBA	-	Gi1/β1/γ2	2.7	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT9 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₁	Homo sapiens	3,5-DHBA	-		2.7	2025-12-10	10.1021/acs.jmedchem.4c02567

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.