psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D105	15.74	Yes	Yes	1	0	9
2	L:L:?1	R:R:Y106	9.35	Yes	Yes	1	0	8
3	L:L:?1	R:R:S109	10.88	Yes	No	1	0	8
4	L:L:?1	R:R:N110	3.98	Yes	No	0	0	8
5	L:L:?1	R:R:A196	5.71	Yes	No	0	0	8
6	L:L:?1	R:R:W378	12.38	Yes	Yes	1	0	8
7	L:L:?1	R:R:Y381	12.75	Yes	Yes	1	0	8
8	L:L:?1	R:R:N382	12.94	Yes	Yes	1	0	8
9	L:L:?1	R:R:Y404	16.15	Yes	Yes	1	0	7
10	L:L:?1	R:R:C407	10.35	Yes	No	1	0	8
11	L:L:?1	R:R:Y408	6.8	Yes	Yes	1	0	8
12	R:R:G29	R:R:I28	3.53	No	No	0	5	7
13	R:R:M79	R:R:T32	4.52	Yes	Yes	0	8	6
14	R:R:T32	R:R:T83	6.28	Yes	No	0	6	8
15	R:R:L34	R:R:L35	2.77	No	Yes	0	5	7
16	R:R:L35	R:R:M79	5.65	Yes	Yes	0	7	8
17	R:R:L35	R:R:W405	3.42	Yes	No	0	7	8
18	R:R:L35	R:R:V409	2.98	Yes	No	0	7	7
19	R:R:M79	R:R:S36	7.67	Yes	No	0	8	7
20	R:R:N80	R:R:S36	4.47	No	No	0	9	7
21	R:R:S411	R:R:T39	4.8	No	No	0	9	8
22	R:R:T39	R:R:T412	4.71	No	No	0	8	8
23	R:R:T76	R:R:V40	4.76	No	No	0	5	7
24	R:R:A68	R:R:N43	3.13	No	No	0	9	9
25	R:R:D71	R:R:N43	4.04	No	No	0	9	9
26	R:R:L72	R:R:N43	6.87	No	No	0	8	9
27	R:R:K57	R:R:Y62	3.58	No	No	0	7	7
28	R:R:N60	R:R:T58	4.39	No	No	0	8	8
29	R:R:N61	R:R:T58	7.31	No	No	0	9	8
30	R:R:R137	R:R:V59	5.23	Yes	No	0	8	7
31	R:R:P139	R:R:Y62	8.34	No	No	0	5	7
32	R:R:F63	R:R:L118	4.87	No	No	0	8	7
33	R:R:F63	R:R:I119	6.28	No	No	0	8	9
34	R:R:L64	R:R:M416	9.9	No	No	0	9	6
35	R:R:N115	R:R:S66	5.96	No	No	0	8	9
36	R:R:I146	R:R:S66	7.74	No	No	0	9	9
37	R:R:S66	R:R:W150	4.94	No	No	0	9	9
38	R:R:L67	R:R:S112	3	No	No	0	9	9
39	R:R:L67	R:R:N115	5.49	No	No	0	9	8
40	R:R:L116	R:R:L67	2.77	No	No	0	8	9
41	R:R:A70	R:R:S112	3.42	No	No	0	9	9
42	R:R:D71	R:R:S411	10.31	No	No	0	9	9
43	R:R:G75	R:R:I74	3.53	No	Yes	0	8	8
44	R:R:I74	R:R:S78	4.64	Yes	Yes	1	8	8
45	R:R:D105	R:R:I74	4.2	Yes	Yes	1	9	8
46	R:R:A108	R:R:I74	3.25	No	Yes	0	7	8
47	R:R:I74	R:R:Y408	4.84	Yes	Yes	1	8	8
48	R:R:G75	R:R:M79	3.49	No	Yes	0	8	8
49	R:R:F77	R:R:T76	11.67	No	No	0	6	5
50	R:R:F77	R:R:L104	4.87	No	No	0	6	6
51	R:R:S78	R:R:W101	4.94	Yes	Yes	1	8	7
52	R:R:D105	R:R:S78	10.31	Yes	Yes	1	9	8
53	R:R:S78	R:R:Y408	7.63	Yes	Yes	1	8	8
54	R:R:M79	R:R:Y408	4.79	Yes	Yes	0	8	8
55	R:R:L81	R:R:T84	4.42	No	No	0	7	7
56	R:R:L81	R:R:W91	5.69	No	Yes	1	7	9
57	R:R:L81	R:R:W101	10.25	No	Yes	1	7	7
58	R:R:Y82	R:R:Y85	6.95	No	Yes	1	7	7
59	R:R:E401	R:R:Y82	12.35	No	No	1	6	7
60	R:R:Y404	R:R:Y82	15.89	Yes	No	1	7	7
61	R:R:L86	R:R:Y85	3.52	No	Yes	1	7	7
62	R:R:W91	R:R:Y85	7.72	Yes	Yes	1	9	7
63	R:R:Q177	R:R:Y85	5.64	No	Yes	0	4	7
64	R:R:E401	R:R:Y85	7.86	No	Yes	1	6	7
65	R:R:E401	R:R:L86	5.3	No	No	1	6	7
66	R:R:L87	R:R:M88	2.83	No	No	0	6	6
67	R:R:G89	R:R:H90	4.77	No	No	0	6	5
68	R:R:G94	R:R:W91	2.81	No	Yes	0	7	9
69	R:R:C98	R:R:W91	3.92	No	Yes	1	9	9
70	R:R:W101	R:R:W91	8.43	Yes	Yes	1	7	9
71	R:R:C178	R:R:W91	6.53	No	Yes	1	9	9
72	R:R:G94	R:R:T95	3.64	No	No	0	7	4
73	R:R:C178	R:R:C98	7.28	No	No	1	9	9
74	R:R:L100	R:R:L104	5.54	No	No	0	6	6
75	R:R:L102	R:R:W101	4.56	No	Yes	1	7	7
76	R:R:C178	R:R:W101	3.92	No	Yes	1	9	7
77	R:R:W101	R:R:Y404	2.89	Yes	Yes	1	7	7
78	R:R:L102	R:R:Y106	3.52	No	Yes	1	7	8
79	R:R:I180	R:R:L102	4.28	Yes	No	1	7	7
80	R:R:A103	R:R:I161	3.25	No	No	0	8	7
81	R:R:D105	R:R:S109	2.94	Yes	No	1	9	8
82	R:R:D105	R:R:Y404	4.6	Yes	Yes	1	9	7
83	R:R:D105	R:R:Y408	10.34	Yes	Yes	1	9	8
84	R:R:W157	R:R:Y106	8.68	No	Yes	0	8	8
85	R:R:I180	R:R:Y106	7.25	Yes	Yes	1	7	8
86	R:R:S109	R:R:W378	4.94	No	Yes	1	8	8
87	R:R:N110	R:R:S153	4.47	No	No	0	8	8
88	R:R:N110	R:R:W157	11.3	No	No	0	8	8
89	R:R:A111	R:R:W150	10.37	No	No	0	8	9
90	R:R:P200	R:R:V113	3.53	No	No	0	9	9
91	R:R:V113	R:R:W378	3.68	No	Yes	0	9	8
92	R:R:M114	R:R:V152	3.04	No	No	0	7	5
93	R:R:I119	R:R:N115	2.83	No	No	0	9	8
94	R:R:L116	R:R:M204	2.83	No	Yes	1	8	9
95	R:R:F374	R:R:L116	4.87	Yes	No	1	9	8
96	R:R:L117	R:R:P200	4.93	No	No	0	7	9
97	R:R:L117	R:R:V203	2.98	No	Yes	0	7	7
98	R:R:L117	R:R:M204	2.83	No	Yes	0	7	9
99	R:R:L118	R:R:M145	4.24	No	No	0	7	7
100	R:R:M204	R:R:S120	4.6	Yes	No	0	9	9
101	R:R:L207	R:R:S120	4.5	Yes	No	0	8	9
102	R:R:F121	R:R:V203	3.93	No	Yes	4	7	7
103	R:R:F121	R:R:L207	7.31	No	Yes	4	7	8
104	R:R:D122	R:R:S126	2.94	No	Yes	2	9	9
105	R:R:D122	R:R:Y133	5.75	No	Yes	2	9	9
106	R:R:D122	R:R:R137	13.1	No	Yes	2	9	8
107	R:R:E360	R:R:R123	5.82	No	No	0	9	9
108	R:R:F125	R:R:Y124	3.09	No	Yes	0	7	8
109	R:R:T128	R:R:Y124	8.74	No	Yes	0	8	8
110	R:R:L207	R:R:Y124	10.55	Yes	Yes	0	8	8
111	R:R:R210	R:R:Y124	11.32	No	Yes	0	7	8
112	R:R:I211	R:R:Y124	4.84	No	Yes	0	9	8
113	R:R:F125	R:R:R129	6.41	No	Yes	0	7	7
114	R:R:F125	R:R:Y133	8.25	No	Yes	0	7	9
115	R:R:S126	R:R:Y133	3.82	Yes	Yes	2	9	9
116	R:R:R137	R:R:S126	7.91	Yes	Yes	2	8	9
117	R:R:I211	R:R:V127	7.68	No	No	0	9	8
118	R:R:R129	R:R:T128	5.17	Yes	No	0	7	8
119	R:R:R129	R:R:S132	3.95	Yes	No	0	7	7
120	R:R:R137	R:R:Y133	14.4	Yes	Yes	2	8	9
121	R:R:P139	R:R:T138	3.5	No	No	0	5	8
122	R:R:L144	R:R:R141	3.64	No	No	0	2	8
123	R:R:M145	R:R:R141	3.72	No	No	0	7	8
124	R:R:G147	R:R:I146	3.53	No	No	0	4	9
125	R:R:F154	R:R:V155	3.93	Yes	No	0	6	5
126	R:R:A158	R:R:F154	5.55	No	Yes	0	6	6
127	R:R:T192	R:R:W157	3.64	No	No	0	8	8
128	R:R:F163	R:R:P159	5.78	No	No	0	6	8
129	R:R:A160	R:R:F182	4.16	No	No	0	7	6
130	R:R:I161	R:R:I180	5.89	No	Yes	0	7	7
131	R:R:F182	R:R:W164	30.07	No	No	0	6	7
132	R:R:L174	R:R:Q177	7.99	No	No	0	3	4
133	R:R:Q177	R:R:Y179	10.15	No	No	0	4	4
134	R:R:I180	R:R:L183	8.56	Yes	Yes	0	7	7
135	R:R:I188	R:R:L183	18.55	No	Yes	0	8	7
136	R:R:L183	R:R:T189	2.95	Yes	No	0	7	7
137	R:R:L183	R:R:T192	7.37	Yes	No	0	7	8
138	R:R:P186	R:R:Q185	4.74	No	No	0	5	7
139	R:R:I188	R:R:Q185	5.49	No	No	0	8	7
140	R:R:T189	R:R:V385	3.17	No	No	0	7	8
141	R:R:F190	R:R:G191	4.52	No	No	0	7	6
142	R:R:A193	R:R:V385	5.09	No	No	0	7	8
143	R:R:M194	R:R:Y198	3.59	No	No	0	6	7
144	R:R:F197	R:R:Y198	10.32	Yes	No	0	9	7
145	R:R:F197	R:R:V201	7.87	Yes	No	0	9	7
146	R:R:F197	R:R:F374	5.36	Yes	Yes	1	9	9
147	R:R:F197	R:R:W378	5.01	Yes	Yes	1	9	8
148	R:R:F197	R:R:N382	21.75	Yes	Yes	1	9	8
149	R:R:L386	R:R:Y198	3.52	No	No	0	7	7
150	R:R:L199	R:R:P200	3.28	No	No	0	7	9
151	R:R:I375	R:R:V201	4.61	No	No	0	7	7
152	R:R:L207	R:R:V203	2.98	Yes	Yes	4	8	7
153	R:R:L371	R:R:M204	4.24	No	Yes	0	7	9
154	R:R:F374	R:R:M204	3.73	Yes	Yes	1	9	9
155	R:R:R210	R:R:T206	5.17	No	No	0	7	5
156	R:R:L367	R:R:Y208	4.69	No	No	0	9	9
157	R:R:S368	R:R:Y208	7.63	No	No	0	7	9
158	R:R:R213	R:R:W209	16.99	No	No	0	5	4
159	R:R:R213	R:R:Y212	9.26	No	No	0	5	7
160	R:R:I370	R:R:T366	3.04	No	No	0	8	8
161	R:R:A369	R:R:P415	3.74	No	No	0	8	9
162	R:R:I370	R:R:P415	5.08	No	No	0	8	9
163	R:R:I370	R:R:M416	4.37	No	No	0	8	6
164	R:R:I375	R:R:L371	4.28	No	No	0	7	7
165	R:R:A373	R:R:I413	3.25	No	No	0	7	6
166	R:R:F374	R:R:I375	5.02	Yes	No	0	9	7
167	R:R:F374	R:R:W378	15.03	Yes	Yes	1	9	8
168	R:R:T377	R:R:V409	3.17	No	No	0	8	7
169	R:R:N410	R:R:T377	7.31	No	No	0	9	8
170	R:R:N382	R:R:W378	3.39	Yes	Yes	1	8	8
171	R:R:C407	R:R:W378	6.53	No	Yes	1	8	8
172	R:R:N410	R:R:W378	7.91	No	Yes	0	9	8
173	R:R:P380	R:R:T379	3.5	No	No	0	9	7
174	R:R:L406	R:R:P380	3.28	No	No	0	8	9
175	R:R:N382	R:R:Y381	3.49	Yes	Yes	1	8	8
176	R:R:W400	R:R:Y381	11.58	No	Yes	0	7	8
177	R:R:Y381	R:R:Y404	9.93	Yes	Yes	1	8	7
178	R:R:M384	R:R:W400	4.65	No	No	0	6	7
179	R:R:P396	R:R:V395	3.53	No	No	3	6	6
180	R:R:L399	R:R:V395	2.98	No	No	3	5	6
181	R:R:V395	R:R:W400	3.68	No	No	0	6	7
182	R:R:P396	R:R:T398	6.99	No	No	3	6	4
183	R:R:L399	R:R:P396	8.21	No	No	3	5	6
184	R:R:E397	R:R:T398	4.23	No	No	0	3	4
185	R:R:L399	R:R:T398	4.42	No	No	3	5	4
186	R:R:L402	R:R:W405	3.42	No	No	0	5	8
187	R:R:L402	R:R:L406	2.77	No	No	0	5	8
188	R:R:G403	R:R:L406	3.42	No	No	0	6	8
189	R:R:Y404	R:R:Y408	3.97	Yes	Yes	1	7	8
190	R:R:L56	R:R:N61	2.75	No	No	0	9	9
191	R:R:D99	R:R:L162	2.71	No	No	0	7	6
192	R:R:R123	R:R:S126	2.64	No	Yes	0	9	9
193	R:R:R134	R:R:S126	2.64	No	Yes	0	7	9
194	R:R:R365	R:R:S368	2.64	No	No	0	7	7
195	R:R:F154	R:R:V107	2.62	Yes	No	0	6	8
196	R:R:S184	R:R:Y179	2.54	No	No	0	6	4
197	R:R:F182	R:R:I161	2.51	No	No	0	6	7
198	R:R:L367	R:R:R123	2.43	No	No	0	9	9
199	R:R:Q181	R:R:W164	2.19	No	No	0	8	7
200	R:R:R210	R:R:W209	2	No	No	0	7	4
201	R:R:A175	R:R:G176	1.95	No	No	0	3	2
202	R:R:A158	R:R:P159	1.87	No	No	0	6	8
203	R:R:G29	R:R:T32	1.82	No	Yes	0	5	6
204	R:R:G33	R:R:T32	1.82	No	Yes	0	5	6
205	R:R:G75	R:R:T39	1.82	No	No	0	8	8
206	R:R:G42	R:R:T41	1.82	No	No	0	9	5
207	R:R:C205	R:R:V201	1.71	No	No	0	5	7
208	R:R:A26	R:R:V25	1.7	No	No	0	5	4
209	R:R:A68	R:R:V46	1.7	No	No	0	9	9
210	R:R:A142	R:R:V59	1.7	No	No	0	8	7
211	R:R:N414	R:R:P415	1.63	No	No	0	9	9
212	R:R:S36	R:R:V40	1.62	No	No	0	7	7
213	R:R:A108	R:R:I73	1.62	No	No	0	7	8
214	R:R:A149	R:R:M114	1.61	No	No	0	8	7
215	R:R:C69	R:R:L47	1.59	No	No	0	6	7
216	R:R:G176	R:R:H90	1.59	No	No	0	2	5
217	R:R:T202	R:R:V203	1.59	No	Yes	0	5	7
218	R:R:A92	R:R:L93	1.58	No	No	0	4	7
219	R:R:A97	R:R:L93	1.58	No	No	0	6	7
220	R:R:A149	R:R:L118	1.58	No	No	0	8	7
221	R:R:T31	R:R:T32	1.57	No	Yes	0	4	6
222	R:R:A373	R:R:N410	1.56	No	No	0	7	9
223	R:R:M416	R:R:V46	1.52	No	No	0	6	9
224	R:R:I383	R:R:T379	1.52	No	No	0	7	7
225	R:R:A364	R:R:E360	1.51	No	No	0	8	9
226	R:R:L44	R:R:V40	1.49	No	No	0	5	7
227	R:R:L45	R:R:V46	1.49	No	No	0	8	9
228	R:R:L37	R:R:T41	1.47	No	No	0	5	5
229	R:R:L96	R:R:T95	1.47	No	No	0	4	4
230	R:R:P130	R:R:R129	1.44	No	Yes	0	8	7
231	R:R:I30	R:R:L34	1.43	No	No	0	4	5
232	R:R:G176	R:R:W91	1.41	No	Yes	0	2	9
233	R:R:L47	R:R:L65	1.38	No	No	0	7	7
234	R:R:L47	R:R:L72	1.38	No	No	0	7	8
235	R:R:L64	R:R:N61	1.37	No	No	0	9	9
236	R:R:I187	R:R:Q185	1.37	No	No	0	5	7
237	R:R:F154	R:R:S153	1.32	Yes	No	0	6	8
238	R:R:A97	R:R:W91	1.3	No	Yes	0	6	9
239	R:R:R140	R:R:T138	1.29	No	No	0	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.6391	11	1	0
2	R:R:T32	3.202	5	0	6
3	R:R:L35	3.705	4	0	7
4	R:R:I74	4.092	5	1	8
5	R:R:S78	6.88	4	1	8
6	R:R:M79	5.224	5	0	8
7	R:R:Y85	6.338	5	1	7
8	R:R:W91	4.72625	8	1	9
9	R:R:W101	5.83167	6	1	7
10	R:R:D105	8.02167	6	1	9
11	R:R:Y106	7.2	4	1	8
12	R:R:Y124	7.708	5	0	8
13	R:R:S126	3.99	5	2	9
14	R:R:R129	4.2425	4	0	7
15	R:R:Y133	8.055	4	2	9
16	R:R:R137	10.16	4	2	8
17	R:R:F154	3.355	4	0	6
18	R:R:I180	6.495	4	1	7
19	R:R:L183	9.3575	4	0	7
20	R:R:F197	10.062	5	1	9
21	R:R:V203	2.87	4	4	7
22	R:R:M204	3.646	5	1	9
23	R:R:L207	6.335	4	4	8
24	R:R:F374	6.802	5	1	9
25	R:R:W378	7.35875	8	1	8
26	R:R:Y381	9.4375	4	1	8
27	R:R:N382	10.3925	4	1	8
28	R:R:Y404	8.905	6	1	7
29	R:R:Y408	6.395	6	1	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y408	69.4965	6.8	Yes	Yes	1	0	8
2	R:R:M79	R:R:Y408	58.5713	4.79	Yes	Yes	0	8	8
3	R:R:L35	R:R:M79	18.2893	5.65	Yes	Yes	0	7	8
4	R:R:L35	R:R:W405	15.234	3.42	Yes	No	0	7	8
5	L:L:?1	R:R:W378	95.8621	12.38	Yes	Yes	1	0	8
6	R:R:N410	R:R:W378	13.425	7.91	No	Yes	0	9	8
7	R:R:M79	R:R:S36	13.4535	7.67	Yes	No	0	8	7
8	L:L:?1	R:R:D105	25.7745	15.74	Yes	Yes	1	0	9
9	R:R:D105	R:R:I74	43.1522	4.2	Yes	Yes	1	9	8
10	R:R:G75	R:R:I74	70.9707	3.53	No	Yes	0	8	8
11	R:R:G75	R:R:T39	96.2538	1.82	No	No	0	8	8
12	R:R:S411	R:R:T39	88.092	4.8	No	No	0	9	8
13	R:R:I74	R:R:Y408	28.5948	4.84	Yes	Yes	1	8	8
14	R:R:G75	R:R:M79	30.4893	3.49	No	Yes	0	8	8
15	R:R:S36	R:R:V40	10.1204	1.62	No	No	0	7	7
16	R:R:D71	R:R:S411	83.9897	10.31	No	No	0	9	9
17	R:R:D71	R:R:N43	79.8732	4.04	No	No	0	9	9
18	R:R:A68	R:R:N43	59.077	3.13	No	No	0	9	9
19	R:R:L72	R:R:N43	17.456	6.87	No	No	0	8	9
20	R:R:A68	R:R:V46	54.875	1.7	No	No	0	9	9
21	R:R:M416	R:R:V46	46.4141	1.52	No	No	0	6	9
22	R:R:L64	R:R:M416	21.772	9.9	No	No	0	9	6
23	R:R:L64	R:R:N61	17.456	1.37	No	No	0	9	9
24	R:R:F374	R:R:W378	100	15.03	Yes	Yes	1	9	8
25	R:R:F374	R:R:M204	69.3683	3.73	Yes	Yes	1	9	9
26	R:R:M204	R:R:S120	64.4968	4.6	Yes	No	0	9	9
27	R:R:L207	R:R:S120	62.7235	4.5	Yes	No	0	8	9
28	R:R:L207	R:R:Y124	60.4444	10.55	Yes	Yes	0	8	8
29	R:R:F125	R:R:Y124	37.0486	3.09	No	Yes	0	7	8
30	R:R:F125	R:R:Y133	29.1361	8.25	No	Yes	0	7	9
31	R:R:F374	R:R:L116	34.1001	4.87	Yes	No	1	9	8
32	R:R:L116	R:R:L67	37.597	2.77	No	No	0	8	9
33	R:R:L67	R:R:N115	31.5718	5.49	No	No	0	9	8
34	R:R:I119	R:R:N115	19.1368	2.83	No	No	0	9	8
35	R:R:F63	R:R:I119	17.0073	6.28	No	No	0	8	9
36	R:R:F63	R:R:L118	15.0986	4.87	No	No	0	8	7
37	R:R:N115	R:R:S66	11.032	5.96	No	No	0	8	9
38	L:L:?1	R:R:Y404	18.5955	16.15	Yes	Yes	1	0	7
39	R:R:W101	R:R:Y404	17.5913	2.89	Yes	Yes	1	7	7
40	R:R:Y404	R:R:Y82	14.2511	15.89	Yes	No	1	7	7
41	R:R:W101	R:R:W91	21.017	8.43	Yes	Yes	1	7	9
42	L:L:?1	R:R:Y106	28.0251	9.35	Yes	Yes	1	0	8
43	R:R:I180	R:R:Y106	23.1892	7.25	Yes	Yes	1	7	8
44	R:R:I161	R:R:I180	12.5347	5.89	No	Yes	0	7	7
45	L:L:?1	R:R:N110	16.872	3.98	Yes	No	0	0	8
46	R:R:N110	R:R:S153	13.2042	4.47	No	No	0	8	8
47	R:R:V113	R:R:W378	11.7727	3.68	No	Yes	0	9	8
48	R:R:P200	R:R:V113	10.1773	3.53	No	No	0	9	9
49	R:R:L117	R:R:V203	11.4949	2.98	No	Yes	0	7	7
50	R:R:S126	R:R:Y133	18.9232	3.82	Yes	Yes	2	9	9
51	R:R:R123	R:R:S126	14.8565	2.64	No	Yes	0	9	9
52	R:R:R210	R:R:Y124	11.1032	11.32	No	Yes	0	7	8
53	R:R:F154	R:R:S153	11.3596	1.32	Yes	No	0	6	8
54	R:R:I180	R:R:L183	15.7824	8.56	Yes	Yes	0	7	7
55	R:R:F197	R:R:Y198	10.099	10.32	Yes	No	0	9	7
56	R:R:F197	R:R:N382	13.4321	21.75	Yes	Yes	1	9	8
57	R:R:I370	R:R:M416	21.3802	4.37	No	No	0	8	6
58	R:R:I370	R:R:P415	13.1116	5.08	No	No	0	8	9
59	R:R:L402	R:R:W405	13.0689	3.42	No	No	0	5	8
60	R:R:L402	R:R:L406	11.2029	2.77	No	No	0	5	8
61	L:L:?1	R:R:Y381	15.0203	12.75	Yes	Yes	1	0	8
62	R:R:W400	R:R:Y381	31.5291	11.58	No	Yes	0	7	8
63	R:R:V395	R:R:W400	24.87	3.68	No	No	0	6	7
64	R:R:P396	R:R:V395	10.6759	3.53	No	No	3	6	6
65	R:R:L399	R:R:V395	10.6759	2.98	No	No	3	5	6
66	R:R:L47	R:R:L72	13.1116	1.38	No	No	0	7	8
67	R:R:D105	R:R:S109	16.7652	2.94	Yes	No	1	9	8
68	R:R:S109	R:R:W378	16.6441	4.94	No	Yes	1	8	8
69	R:R:S78	R:R:W101	11.324	4.94	Yes	Yes	1	8	7
70	R:R:Y381	R:R:Y404	10.8753	9.93	Yes	Yes	1	8	7
71	R:R:N382	R:R:Y381	11.4023	3.49	Yes	Yes	1	8	8
72	R:R:Y404	R:R:Y408	14.1657	3.97	Yes	Yes	1	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D105	15.74	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Y106	9.35	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:S109	10.88	1	Yes	No	0	8	0	1
L:L:?1	R:R:N110	3.98	1	Yes	No	0	8	0	1
L:L:?1	R:R:A196	5.71	1	Yes	No	0	8	0	1
L:L:?1	R:R:W378	12.38	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y381	12.75	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:N382	12.94	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y404	16.15	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:C407	10.35	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y408	6.8	1	Yes	Yes	0	8	0	1
R:R:I74	R:R:S78	4.64	1	Yes	Yes	8	8	2	2
R:R:D105	R:R:I74	4.2	1	Yes	Yes	9	8	1	2
R:R:I74	R:R:Y408	4.84	1	Yes	Yes	8	8	2	1
R:R:S78	R:R:W101	4.94	1	Yes	Yes	8	7	2	2
R:R:D105	R:R:S78	10.31	1	Yes	Yes	9	8	1	2
R:R:S78	R:R:Y408	7.63	1	Yes	Yes	8	8	2	1
R:R:M79	R:R:Y408	4.79	0	Yes	Yes	8	8	2	1
R:R:Y404	R:R:Y82	15.89	1	Yes	No	7	7	1	2
R:R:L102	R:R:W101	4.56	1	No	Yes	7	7	2	2
R:R:W101	R:R:Y404	2.89	1	Yes	Yes	7	7	2	1
R:R:L102	R:R:Y106	3.52	1	No	Yes	7	8	2	1
R:R:I180	R:R:L102	4.28	1	Yes	No	7	7	2	2
R:R:D105	R:R:S109	2.94	1	Yes	No	9	8	1	1
R:R:D105	R:R:Y404	4.6	1	Yes	Yes	9	7	1	1
R:R:D105	R:R:Y408	10.34	1	Yes	Yes	9	8	1	1
R:R:W157	R:R:Y106	8.68	0	No	Yes	8	8	2	1
R:R:I180	R:R:Y106	7.25	1	Yes	Yes	7	8	2	1
R:R:S109	R:R:W378	4.94	1	No	Yes	8	8	1	1
R:R:N110	R:R:S153	4.47	0	No	No	8	8	1	2
R:R:N110	R:R:W157	11.3	0	No	No	8	8	1	2
R:R:V113	R:R:W378	3.68	0	No	Yes	9	8	2	1
R:R:F197	R:R:F374	5.36	1	Yes	Yes	9	9	2	2
R:R:F197	R:R:W378	5.01	1	Yes	Yes	9	8	2	1
R:R:F197	R:R:N382	21.75	1	Yes	Yes	9	8	2	1
R:R:F374	R:R:W378	15.03	1	Yes	Yes	9	8	2	1
R:R:N382	R:R:W378	3.39	1	Yes	Yes	8	8	1	1
R:R:C407	R:R:W378	6.53	1	No	Yes	8	8	1	1
R:R:N410	R:R:W378	7.91	0	No	Yes	9	8	2	1
R:R:N382	R:R:Y381	3.49	1	Yes	Yes	8	8	1	1
R:R:W400	R:R:Y381	11.58	0	No	Yes	7	8	2	1
R:R:Y381	R:R:Y404	9.93	1	Yes	Yes	8	7	1	1
R:R:Y404	R:R:Y408	3.97	1	Yes	Yes	7	8	1	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9JEA_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.77
Number of Linked Nodes	207
Number of Links	239
Number of Hubs	29
Number of Links mediated by Hubs	111
Number of Communities	4
Number of Nodes involved in Communities	38
Number of Links involved in Communities	64

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	34972
Length Of Smallest Path	3
Average Path Length	12.235
Length of Longest Path	29
Minimum Path Strength	1.355
Average Path Strength	6.12173
Maximum Path Strength	17.115
Minimum Path Correlation	0.7
Average Path Correlation	0.914395
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	49.6419
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.9627
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• phosphoric ester hydrolase activity • phospholipase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • glycerophospholipase activity • hydrolase activity • C-type glycerophospholipase activity • phosphatidylinositol-4,5-bisphosphate phospholipase C activity • catalytic activity • lipase activity • neurotransmitter receptor activity • G protein-coupled amine receptor activity • G protein-coupled acetylcholine receptor activity • postsynaptic neurotransmitter receptor activity • molecular transducer activity • G protein-coupled receptor activity • signaling receptor activity • transmembrane signaling receptor activity • G protein-coupled neurotransmitter receptor activity • acetylcholine receptor activity • regulation of localization • regulation of biological process • transport • regulation of transport • regulation of monoatomic ion transport • biological regulation • positive regulation of biological process • establishment of localization • localization • positive regulation of transport • positive regulation of monoatomic ion transport • monoatomic ion transport • cellular response to stimulus • cellular response to nitrogen compound
Gene Ontology	Biological Process	• regulation of localization • regulation of biological process • transport • regulation of transport • regulation of monoatomic ion transport • biological regulation • positive regulation of biological process • establishment of localization • localization • positive regulation of transport • positive regulation of monoatomic ion transport • monoatomic ion transport • cellular response to stimulus • cellular response to nitrogen compound • regulation of cellular process • response to stimulus • signaling • cell communication • synaptic signaling • signal transduction • cellular response to acetylcholine • response to oxygen-containing compound • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to acetylcholine • G protein-coupled receptor signaling pathway • cellular process • adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway • multicellular organismal process • regulation of body fluid levels • system process • secretion by tissue • digestive system process • secretion • body fluid secretion • digestion • saliva secretion • regulation of biological quality • nervous system process • cognition • regulation of postsynaptic membrane potential • regulation of membrane potential • trans-synaptic signaling • chemical synaptic transmission • anterograde trans-synaptic signaling • neuromuscular synaptic transmission • regulation of signaling • modulation of chemical synaptic transmission • regulation of trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • regulation of cell communication • developmental process • multicellular organism development • anatomical structure development • nervous system development • system development • cell population proliferation • cellular developmental process • neurogenesis • regulation of glial cell proliferation • gliogenesis • cell differentiation • regulation of cell population proliferation • glial cell proliferation • establishment of protein localization • cellular localization • regulation of protein localization • positive regulation of establishment of protein localization • positive regulation of protein transport • establishment of localization in cell • positive regulation of intracellular transport • intracellular protein localization • positive regulation of cellular process • regulation of intracellular transport • regulation of establishment of protein localization • intracellular transport • regulation of protein transport • protein transport • regulation of cellular localization • macromolecule localization • positive regulation of protein localization • regulation of intracellular protein transport • positive regulation of intracellular protein transport • intracellular protein transport • regulation of locomotion • locomotion • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • postsynaptic specialization membrane • postsynaptic specialization • synapse • membrane • plasma membrane • postsynaptic density membrane • synaptic membrane • cell periphery • postsynaptic density • postsynapse • cellular anatomical structure • neuron to neuron synapse • organelle • cell junction
Gene Ontology	Cellular Component	• postsynaptic specialization membrane • postsynaptic specialization • synapse • membrane • plasma membrane • postsynaptic density membrane • synaptic membrane • cell periphery • postsynaptic density • postsynapse • cellular anatomical structure • neuron to neuron synapse • organelle • cell junction • postsynaptic membrane • asymmetric synapse • plasma membrane region • presynapse • presynaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • cholinergic synapse • glutamatergic synapse • Schaffer collateral - CA1 synapse • axon • axon terminus • distal axon • neuron projection terminus
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P11229
Sequence	>9JEA_nogp_Chain_R V A F I G I T T G L L S L A T V T G N L L V L T L K T V N N Y F L L S L A C A D L I I G T F S M N L Y T T Y L L M G H W A L G T L A C D L W L A L D Y V A S N A S V M N L L L I S F D R Y F S V T R P L S Y R A K R T P R R A A L M I G L A W L V S F V L W A P A I L F W Q L A G Q C Y I Q F L S Q P I I T F G T A M A A F Y L P V T V M C T L Y W R I Y R K E K K A A R T L S A I L L A F I L T W T P Y N I M V L V S V P E T L W E L G Y W L C Y V N S T I N P M C K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4ZUD	A	Peptide	Angiotensin	AT₁	Homo sapiens	Olmesartan	-	-	2.8	2015-10-07	doi.org/10.1074/jbc.M115.689000
	5CXV	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	Tiotropium	-	-	2.7	2016-03-09	doi.org/10.1038/nature17188
	5XR8	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM12033	-	-	2.95	2017-07-12	doi.org/10.1038/nature23272
	5XRA	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM11542	-	-	2.8	2017-07-12	doi.org/10.1038/nature23272
	5OM1	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 135566609	Na	-	2.1	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5ZTY	A	Lipid	Cannabinoid	CB₂	Homo sapiens	AM10257	-	-	2.8	2019-01-30	doi.org/10.1016/j.cell.2018.12.011
	6OIJ	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	Iperoxo	-	chim(NtGi1L-G11)/β1/γ2	3.3	2019-05-08	doi.org/10.1126/science.aaw5188
	6OIJ (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	Iperoxo	-		3.3	2019-05-08	doi.org/10.1126/science.aaw5188
	6KPC	A	Lipid	Cannabinoid	CB₂	Homo sapiens	AM12033	-	-	3.2	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPF	A	Lipid	Cannabinoid	CB₂	Homo sapiens	AM12033	-	Gi1/β1/γ2	2.9	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPF (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	AM12033	-		2.9	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6M1H	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	Maxadilan	-	Gs/β1/γ2	3.6	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	6M1H (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	Maxadilan	-		3.6	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	6M1I	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-	Gs/β1/γ2	3.5	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	6M1I (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-		3.5	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	6UUN	B1	Peptide	Calcitonin	CT Like (AM1)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP2	3	2020-03-25	doi.org/10.1021/acsptsci.9b00080
	6UUN (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM1)	Homo sapiens	Adrenomedullin	-		3	2020-03-25	doi.org/10.1021/acsptsci.9b00080
	6WJC	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	Atropine	Muscarinic toxin 7	-	2.55	2020-07-08	doi.org/10.1126/science.aax2517
	6ZFZ	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	77-LH-28-1	-	-	2.17	2021-10-06	doi.org/10.1016/j.cell.2021.11.001
	6ZG4	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	HTL0009936	-	-	2.33	2021-10-06	doi.org/10.1016/j.cell.2021.11.001
	6ZG9	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	GSK1034702	-	-	2.5	2021-10-06	doi.org/10.1016/j.cell.2021.11.001
	9M1H	A	Lipid	Prostanoid	EP₁	Homo sapiens	PGE2	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.55	2025-04-09	doi.org/10.1073/pnas.2423840122
	9M1H (No Gprot)	A	Lipid	Prostanoid	EP₁	Homo sapiens	PGE2	-		2.55	2025-04-09	doi.org/10.1073/pnas.2423840122
	9BUY	A	Amine	Adrenergic	β₂	Homo sapiens	LM189	-	Gi1/β1/γ2	2.9	2025-05-28	doi.org/10.1126/sciadv.adq3971
	9BUY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	LM189	-		2.9	2025-05-28	doi.org/10.1126/sciadv.adq3971
	9JEA	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	Atropine	-	-	3.4	2025-07-09	To be published
	9JEA (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	Atropine	-		3.4	2025-07-09	To be published
	9M1O	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Neuropeptide-FF	-	Gi1/β1/γ2	2.49	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M1O (No Gprot)	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Neuropeptide-FF	-		2.49	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9UAP	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	-	-	G11(CT)	3.62	2025-10-29	To be published
	9UAP (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	-	-		3.62	2025-10-29	To be published
	9UAZ	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	Atropine	-	-	3.29	2025-10-29	To be published
	9UAZ (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	Atropine	-		3.29	2025-10-29	To be published
	9UCP	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	Iperoxo	-	G11(CT)	2.88	2025-10-29	To be published
	9UCP (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	Iperoxo	-		2.88	2025-10-29	To be published

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.