psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y106	5.1	Yes	Yes	1	0	8
2	L:L:?1	R:R:S109	8.71	Yes	No	0	0	8
3	L:L:?1	R:R:W157	5.78	Yes	Yes	1	0	8
4	L:L:?1	R:R:T192	4.27	Yes	No	0	0	8
5	L:L:?1	R:R:A196	5.71	Yes	No	0	0	8
6	L:L:?1	R:R:W378	17.34	Yes	Yes	1	0	8
7	L:L:?1	R:R:Y381	6.8	Yes	Yes	1	0	8
8	L:L:?1	R:R:N382	3.98	Yes	No	1	0	8
9	L:L:?1	R:R:Y404	11.05	Yes	Yes	1	0	7
10	L:L:?1	R:R:C407	8.05	Yes	No	0	0	8
11	L:L:?1	R:R:Y408	6.8	Yes	Yes	1	0	8
12	R:R:G29	R:R:I28	3.53	No	No	0	5	7
13	R:R:I28	R:R:T32	6.08	No	Yes	0	7	6
14	R:R:I28	R:R:L87	9.99	No	No	0	7	6
15	R:R:T32	R:R:T83	12.56	Yes	No	0	6	8
16	R:R:T32	R:R:W405	4.85	Yes	No	0	6	8
17	R:R:L35	R:R:T412	13.27	No	No	0	7	8
18	R:R:L37	R:R:T41	5.9	No	No	0	5	5
19	R:R:T39	R:R:T412	6.28	No	No	0	8	8
20	R:R:T76	R:R:V40	4.76	No	No	0	5	7
21	R:R:G42	R:R:L45	5.13	No	No	0	9	8
22	R:R:G42	R:R:P415	4.06	No	No	0	9	9
23	R:R:L47	R:R:N43	8.24	No	Yes	0	7	9
24	R:R:A68	R:R:N43	4.69	No	Yes	0	9	9
25	R:R:D71	R:R:N43	12.12	Yes	Yes	0	9	9
26	R:R:L72	R:R:N43	16.48	No	Yes	0	8	9
27	R:R:I48	R:R:L44	5.71	No	No	0	6	5
28	R:R:C69	R:R:L47	4.76	No	No	0	6	7
29	R:R:F50	R:R:K57	12.41	No	No	0	8	7
30	R:R:F50	R:R:L65	3.65	No	No	0	8	7
31	R:R:N53	R:R:V52	5.91	No	No	0	8	7
32	R:R:L56	R:R:N53	4.12	Yes	No	0	9	8
33	R:R:K57	R:R:Y62	9.55	No	No	0	7	7
34	R:R:N61	R:R:T58	4.39	No	No	0	9	8
35	R:R:R137	R:R:V59	10.46	No	Yes	0	8	7
36	R:R:P139	R:R:V59	3.53	No	Yes	0	5	7
37	R:R:A142	R:R:V59	5.09	No	Yes	0	8	7
38	R:R:I146	R:R:Y62	6.04	Yes	No	0	9	7
39	R:R:F63	R:R:N115	3.62	Yes	No	0	8	8
40	R:R:F63	R:R:L118	6.09	Yes	No	0	8	7
41	R:R:F63	R:R:I119	5.02	Yes	No	0	8	9
42	R:R:D122	R:R:F63	4.78	No	Yes	0	9	8
43	R:R:F63	R:R:I146	5.02	Yes	Yes	0	8	9
44	R:R:L64	R:R:Y418	8.21	No	No	0	9	9
45	R:R:N115	R:R:S66	5.96	No	No	0	8	9
46	R:R:I146	R:R:S66	7.74	Yes	No	0	9	9
47	R:R:S66	R:R:W150	7.41	No	Yes	0	9	9
48	R:R:L67	R:R:N414	5.49	No	Yes	1	9	9
49	R:R:L67	R:R:Y418	5.86	No	No	1	9	9
50	R:R:D71	R:R:S411	4.42	Yes	No	0	9	9
51	R:R:L72	R:R:T76	4.42	No	No	0	8	5
52	R:R:I73	R:R:L104	5.71	No	No	0	8	6
53	R:R:A108	R:R:I73	3.25	No	No	0	7	8
54	R:R:I74	R:R:S78	6.19	Yes	No	1	8	8
55	R:R:D105	R:R:I74	5.6	Yes	Yes	1	9	8
56	R:R:A108	R:R:I74	4.87	No	Yes	0	7	8
57	R:R:I74	R:R:S411	7.74	Yes	No	0	8	9
58	R:R:F77	R:R:T76	11.67	No	No	0	6	5
59	R:R:F77	R:R:L104	4.87	No	No	0	6	6
60	R:R:D105	R:R:S78	11.78	Yes	No	1	9	8
61	R:R:S78	R:R:Y408	5.09	No	Yes	1	8	8
62	R:R:N80	R:R:T84	4.39	No	No	0	9	7
63	R:R:L81	R:R:W101	12.53	No	No	0	7	7
64	R:R:L86	R:R:Y82	3.52	No	Yes	0	7	7
65	R:R:E401	R:R:Y82	3.37	No	Yes	0	6	7
66	R:R:Y404	R:R:Y82	10.92	Yes	Yes	1	7	7
67	R:R:W405	R:R:Y82	5.79	No	Yes	0	8	7
68	R:R:Y408	R:R:Y82	8.94	Yes	Yes	1	8	7
69	R:R:A92	R:R:Y85	4	No	Yes	0	4	7
70	R:R:Q177	R:R:Y85	11.27	No	Yes	0	4	7
71	R:R:C178	R:R:Y85	9.41	No	Yes	0	9	7
72	R:R:H90	R:R:M88	6.57	No	No	0	5	6
73	R:R:T95	R:R:W91	31.53	No	No	0	4	9
74	R:R:C98	R:R:T95	3.38	No	No	0	9	4
75	R:R:A97	R:R:W101	7.78	No	No	0	6	7
76	R:R:D99	R:R:L100	6.79	No	No	0	7	6
77	R:R:D99	R:R:L162	8.14	No	No	0	7	6
78	R:R:A103	R:R:I161	3.25	No	Yes	0	8	7
79	R:R:A103	R:R:L162	4.73	No	No	0	8	6
80	R:R:D105	R:R:Y106	4.6	Yes	Yes	1	9	8
81	R:R:D105	R:R:Y408	12.64	Yes	Yes	1	9	8
82	R:R:W157	R:R:Y106	13.5	Yes	Yes	1	8	8
83	R:R:I161	R:R:Y106	9.67	Yes	Yes	1	7	8
84	R:R:I180	R:R:Y106	9.67	Yes	Yes	1	7	8
85	R:R:L183	R:R:Y106	4.69	No	Yes	1	7	8
86	R:R:V107	R:R:W150	3.68	No	Yes	0	8	9
87	R:R:N110	R:R:S153	4.47	No	No	1	8	8
88	R:R:L156	R:R:N110	6.87	No	No	1	8	8
89	R:R:N110	R:R:W157	14.69	No	Yes	1	8	8
90	R:R:A111	R:R:W150	10.37	No	Yes	1	8	9
91	R:R:A111	R:R:S153	3.42	No	No	1	8	8
92	R:R:P200	R:R:V113	3.53	No	No	0	9	9
93	R:R:L117	R:R:M114	5.65	No	No	0	7	7
94	R:R:I370	R:R:L116	4.28	Yes	No	0	8	8
95	R:R:L118	R:R:M145	8.48	No	No	0	7	7
96	R:R:I119	R:R:R123	5.01	No	No	0	9	9
97	R:R:M204	R:R:S120	6.13	No	No	0	9	9
98	R:R:F121	R:R:F125	7.5	Yes	No	0	7	7
99	R:R:F121	R:R:L207	7.31	Yes	No	0	7	8
100	R:R:D122	R:R:R137	3.57	No	No	0	9	8
101	R:R:A363	R:R:R123	4.15	No	No	0	9	9
102	R:R:L367	R:R:R123	7.29	No	No	0	9	9
103	R:R:T128	R:R:Y124	8.74	No	No	0	8	8
104	R:R:L207	R:R:Y124	10.55	No	No	0	8	8
105	R:R:R210	R:R:Y124	12.35	No	No	0	7	8
106	R:R:F125	R:R:Y133	14.44	No	No	0	7	9
107	R:R:R129	R:R:T128	3.88	No	No	0	7	8
108	R:R:L131	R:R:P130	6.57	No	No	0	7	8
109	R:R:R134	R:R:R137	4.26	No	No	0	7	8
110	R:R:K136	R:R:R141	8.66	No	No	0	6	8
111	R:R:P139	R:R:T138	8.74	No	No	0	5	8
112	R:R:M145	R:R:R141	6.2	No	No	0	7	8
113	R:R:S153	R:R:W150	3.71	No	Yes	1	8	9
114	R:R:F154	R:R:W150	4.01	No	Yes	0	6	9
115	R:R:A158	R:R:F154	4.16	No	No	0	6	6
116	R:R:L156	R:R:W157	3.42	No	Yes	1	8	8
117	R:R:I161	R:R:W157	4.7	Yes	Yes	1	7	8
118	R:R:F182	R:R:W157	5.01	Yes	Yes	1	6	8
119	R:R:I161	R:R:I180	5.89	Yes	Yes	1	7	7
120	R:R:F182	R:R:I161	3.77	Yes	Yes	1	6	7
121	R:R:F163	R:R:L162	9.74	No	No	0	6	6
122	R:R:F163	R:R:Y166	7.22	No	No	0	6	5
123	R:R:F182	R:R:W164	20.04	Yes	No	0	6	7
124	R:R:Q165	R:R:Y166	13.53	No	No	0	7	5
125	R:R:Q165	R:R:V173	4.3	No	Yes	0	7	4
126	R:R:E170	R:R:L174	15.9	No	No	0	4	3
127	R:R:G176	R:R:Y179	5.79	No	No	0	2	4
128	R:R:Q177	R:R:Y179	18.04	No	No	0	4	4
129	R:R:F182	R:R:I180	11.3	Yes	Yes	1	6	7
130	R:R:I180	R:R:L183	7.14	Yes	No	1	7	7
131	R:R:F182	R:R:L183	3.65	Yes	No	1	6	7
132	R:R:I188	R:R:Q185	9.61	No	No	0	8	7
133	R:R:F190	R:R:M194	9.95	Yes	No	1	7	6
134	R:R:F190	R:R:Y198	5.16	Yes	Yes	1	7	7
135	R:R:F190	R:R:L386	7.31	Yes	No	1	7	7
136	R:R:M194	R:R:Y198	9.58	No	Yes	1	6	7
137	R:R:F197	R:R:Y198	8.25	Yes	Yes	1	9	7
138	R:R:F197	R:R:V201	13.11	Yes	Yes	1	9	7
139	R:R:F197	R:R:F374	7.5	Yes	Yes	1	9	9
140	R:R:F197	R:R:T379	5.19	Yes	No	0	9	7
141	R:R:F197	R:R:N382	22.96	Yes	No	1	9	8
142	R:R:N382	R:R:Y198	11.63	No	Yes	1	8	7
143	R:R:L386	R:R:Y198	11.72	No	Yes	1	7	7
144	R:R:L199	R:R:P200	3.28	No	No	0	7	9
145	R:R:F374	R:R:V201	3.93	Yes	Yes	1	9	7
146	R:R:L371	R:R:M204	7.07	No	No	0	7	9
147	R:R:R210	R:R:T206	5.17	No	No	0	7	5
148	R:R:I211	R:R:Y208	4.84	No	No	0	9	9
149	R:R:S368	R:R:Y208	6.36	No	No	0	7	9
150	R:R:E360	R:R:K359	10.8	No	No	0	9	7
151	R:R:K362	R:R:R365	3.71	No	No	0	8	7
152	R:R:I370	R:R:N414	7.08	Yes	Yes	0	8	9
153	R:R:C417	R:R:I370	3.27	No	Yes	0	8	8
154	R:R:L372	R:R:L376	4.15	No	No	0	7	5
155	R:R:F374	R:R:W378	22.05	Yes	Yes	1	9	8
156	R:R:T377	R:R:W378	6.06	No	Yes	1	8	8
157	R:R:N410	R:R:T377	4.39	No	No	1	9	8
158	R:R:N410	R:R:W378	7.91	No	Yes	1	9	8
159	R:R:P380	R:R:T379	8.74	No	No	0	9	7
160	R:R:I383	R:R:T379	4.56	No	No	0	7	7
161	R:R:V385	R:R:Y381	3.79	Yes	Yes	1	8	8
162	R:R:W400	R:R:Y381	7.72	Yes	Yes	1	7	8
163	R:R:Y381	R:R:Y404	9.93	Yes	Yes	1	8	7
164	R:R:M384	R:R:V395	10.65	No	No	1	6	6
165	R:R:M384	R:R:W400	12.8	No	Yes	1	6	7
166	R:R:V385	R:R:W400	3.68	Yes	Yes	1	8	7
167	R:R:C394	R:R:V387	3.42	No	No	0	8	6
168	R:R:S388	R:R:W400	6.18	No	Yes	0	5	7
169	R:R:F390	R:R:T389	3.89	No	No	0	5	8
170	R:R:P396	R:R:V395	3.53	No	No	0	6	6
171	R:R:V395	R:R:W400	4.9	No	Yes	1	6	7
172	R:R:P396	R:R:T398	3.5	No	No	0	6	4
173	R:R:L399	R:R:P396	3.28	No	No	0	5	6
174	R:R:E397	R:R:E401	10.15	No	No	0	3	6
175	R:R:Y404	R:R:Y408	8.94	Yes	Yes	1	7	8
176	R:R:V409	R:R:W405	7.36	No	No	0	7	8
177	R:R:N410	R:R:N414	5.45	No	Yes	1	9	9
178	R:R:C417	R:R:I413	3.27	No	No	0	8	6
179	R:R:N414	R:R:Y418	4.65	Yes	No	1	9	9
180	R:R:D71	R:R:P415	3.22	Yes	No	0	9	9
181	R:R:T172	R:R:V173	3.17	No	Yes	0	4	4
182	R:R:T189	R:R:V385	3.17	No	Yes	0	7	8
183	R:R:P186	R:R:Q185	3.16	No	No	0	5	7
184	R:R:M79	R:R:S36	3.07	No	No	0	8	7
185	R:R:I375	R:R:V201	3.07	No	Yes	0	7	7
186	R:R:I30	R:R:T31	3.04	No	No	0	4	4
187	R:R:M114	R:R:V152	3.04	No	No	0	7	5
188	R:R:I370	R:R:T366	3.04	Yes	No	0	8	8
189	R:R:M79	R:R:T39	3.01	No	No	0	8	8
190	R:R:L148	R:R:V152	2.98	No	No	0	4	5
191	R:R:L156	R:R:V152	2.98	No	No	0	8	5
192	R:R:L406	R:R:V409	2.98	No	No	0	8	7
193	R:R:N43	R:R:V46	2.96	Yes	No	0	9	9
194	R:R:N60	R:R:V59	2.96	No	Yes	0	8	7
195	R:R:D71	R:R:T39	2.89	Yes	No	0	9	8
196	R:R:Q181	R:R:V173	2.87	No	Yes	0	8	4
197	R:R:A160	R:R:F182	2.77	No	Yes	0	7	6
198	R:R:L56	R:R:N61	2.75	Yes	No	0	9	9
199	R:R:L81	R:R:N80	2.75	No	No	0	7	9
200	R:R:L174	R:R:Q181	2.66	No	No	0	3	8
201	R:R:F374	R:R:V113	2.62	Yes	No	0	9	9
202	R:R:F121	R:R:V203	2.62	Yes	No	0	7	7
203	R:R:A70	R:R:W150	2.59	No	Yes	0	9	9
204	R:R:F121	R:R:L117	2.44	Yes	No	0	7	7
205	R:R:F390	R:R:L386	2.44	No	No	0	5	7
206	R:R:L100	R:R:W101	2.28	No	No	0	6	7
207	R:R:W91	R:R:Y85	1.93	No	Yes	0	9	7
208	R:R:A158	R:R:P159	1.87	No	No	0	6	8
209	R:R:G75	R:R:V40	1.84	No	No	0	8	7
210	R:R:G33	R:R:T32	1.82	No	Yes	0	5	6
211	R:R:G42	R:R:T41	1.82	No	No	0	9	5
212	R:R:A369	R:R:C417	1.81	No	No	0	8	8
213	R:R:G147	R:R:I146	1.76	No	Yes	0	4	9
214	R:R:P186	R:R:T389	1.75	No	No	0	5	8
215	R:R:G176	R:R:L93	1.71	No	No	0	2	7
216	R:R:C205	R:R:V201	1.71	No	Yes	0	5	7
217	R:R:G403	R:R:L402	1.71	No	No	0	6	5
218	R:R:G403	R:R:L406	1.71	No	No	0	6	8
219	R:R:A193	R:R:V385	1.7	No	Yes	0	7	8
220	R:R:A38	R:R:T412	1.68	No	No	0	5	8
221	R:R:A97	R:R:T95	1.68	No	No	0	6	4
222	R:R:M204	R:R:P200	1.68	No	No	0	9	9
223	R:R:S109	R:R:S112	1.63	No	No	0	8	9
224	R:R:A373	R:R:I413	1.62	No	No	0	7	6
225	R:R:A149	R:R:M114	1.61	No	No	0	8	7
226	R:R:T58	R:R:V59	1.59	No	Yes	0	8	7
227	R:R:T128	R:R:V127	1.59	No	No	0	8	8
228	R:R:A175	R:R:L174	1.58	No	No	0	3	3
229	R:R:T31	R:R:T32	1.57	No	Yes	0	4	6
230	R:R:I211	R:R:V127	1.54	No	No	0	9	8
231	R:R:F190	R:R:G191	1.51	Yes	No	0	7	6
232	R:R:L56	R:R:S49	1.5	Yes	No	0	9	9
233	R:R:L87	R:R:V25	1.49	No	No	0	6	4
234	R:R:L96	R:R:V173	1.49	No	Yes	0	4	4
235	R:R:I187	R:R:I188	1.47	No	No	0	5	8
236	R:R:L199	R:R:T202	1.47	No	No	0	7	5
237	R:R:G89	R:R:Y85	1.45	No	Yes	0	6	7
238	R:R:P130	R:R:R129	1.44	No	No	0	8	7
239	R:R:I161	R:R:L102	1.43	Yes	No	1	7	7
240	R:R:I180	R:R:L102	1.43	Yes	No	1	7	7
241	R:R:E55	R:R:L56	1.33	No	Yes	0	7	9
242	R:R:R129	R:R:S132	1.32	No	No	0	7	7
243	R:R:R140	R:R:T138	1.29	No	No	0	6	8
244	R:R:F50	R:R:K51	1.24	No	No	0	8	5
245	R:R:K361	R:R:R365	1.24	No	No	0	7	7
246	R:R:F154	R:R:L151	1.22	No	No	0	6	4
247	R:R:F27	R:R:W23	1	No	No	0	3	4
248	R:R:Y208	R:R:Y212	0.99	No	No	0	9	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.59909	11	1	0
2	R:R:T32	5.376	5	0	6
3	R:R:N43	8.898	5	0	9
4	R:R:L56	2.425	4	0	9
5	R:R:V59	4.726	5	0	7
6	R:R:F63	4.906	5	0	8
7	R:R:D71	5.6625	4	0	9
8	R:R:I74	6.1	4	1	8
9	R:R:Y82	6.508	5	1	7
10	R:R:Y85	5.612	5	0	7
11	R:R:D105	8.655	4	1	9
12	R:R:Y106	7.87167	6	1	8
13	R:R:F121	4.9675	4	0	7
14	R:R:I146	5.14	4	0	9
15	R:R:W150	5.295	6	1	9
16	R:R:W157	7.85	6	1	8
17	R:R:I161	4.785	6	1	7
18	R:R:V173	2.9575	4	0	4
19	R:R:I180	7.086	5	1	7
20	R:R:F182	7.75667	6	1	6
21	R:R:F190	5.9825	4	1	7
22	R:R:F197	11.402	5	1	9
23	R:R:Y198	9.268	5	1	7
24	R:R:V201	5.455	4	1	7
25	R:R:I370	4.4175	4	0	8
26	R:R:F374	9.025	4	1	9
27	R:R:W378	13.34	4	1	8
28	R:R:Y381	7.06	4	1	8
29	R:R:V385	3.085	4	1	8
30	R:R:W400	7.056	5	1	7
31	R:R:Y404	10.21	4	1	7
32	R:R:Y408	8.482	5	1	8
33	R:R:N414	5.6675	4	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y404	30.4218	11.05	Yes	Yes	1	0	7
2	R:R:Y404	R:R:Y82	30.6518	10.92	Yes	Yes	1	7	7
3	R:R:W405	R:R:Y82	57.7991	5.79	No	Yes	0	8	7
4	R:R:T32	R:R:W405	37.2546	4.85	Yes	No	0	6	8
5	R:R:I28	R:R:T32	16.9939	6.08	No	Yes	0	7	6
6	L:L:?1	R:R:Y408	60.115	6.8	Yes	Yes	1	0	8
7	R:R:Y408	R:R:Y82	42.2929	8.94	Yes	Yes	1	8	7
8	L:L:?1	R:R:Y106	40.9816	5.1	Yes	Yes	1	0	8
9	R:R:D105	R:R:Y106	54.1258	4.6	Yes	Yes	1	9	8
10	R:R:D105	R:R:I74	67.6074	5.6	Yes	Yes	1	9	8
11	R:R:I74	R:R:S411	65.5598	7.74	Yes	No	0	8	9
12	R:R:D71	R:R:S411	62.7071	4.42	Yes	No	0	9	9
13	R:R:D71	R:R:T39	18.9034	2.89	Yes	No	0	9	8
14	R:R:D105	R:R:Y408	26.8405	12.64	Yes	Yes	1	9	8
15	R:R:S78	R:R:Y408	22.4693	5.09	No	Yes	1	8	8
16	R:R:I74	R:R:S78	21.25	6.19	Yes	No	1	8	8
17	R:R:D71	R:R:P415	15.7899	3.22	Yes	No	0	9	9
18	R:R:G42	R:R:P415	12.661	4.06	No	No	0	9	9
19	R:R:A108	R:R:I74	21.319	4.87	No	Yes	0	7	8
20	R:R:A108	R:R:I73	18.2362	3.25	No	No	0	7	8
21	R:R:I73	R:R:L104	15.184	5.71	No	No	0	8	6
22	R:R:F77	R:R:L104	12.2469	4.87	No	No	0	6	6
23	R:R:D71	R:R:N43	27.4617	12.12	Yes	Yes	0	9	9
24	R:R:L72	R:R:N43	12.8221	16.48	No	Yes	0	8	9
25	R:R:T76	R:R:V40	12.3236	4.76	No	No	0	5	7
26	L:L:?1	R:R:W157	95.2684	5.78	Yes	Yes	1	0	8
27	R:R:N110	R:R:W157	88.4739	14.69	No	Yes	1	8	8
28	R:R:N110	R:R:S153	100	4.47	No	No	1	8	8
29	R:R:S153	R:R:W150	97.454	3.71	No	Yes	1	8	9
30	R:R:S66	R:R:W150	90.3374	7.41	No	Yes	0	9	9
31	R:R:I146	R:R:S66	49.4479	7.74	Yes	No	0	9	9
32	R:R:N115	R:R:S66	39.8313	5.96	No	No	0	8	9
33	R:R:F63	R:R:N115	38.3589	3.62	Yes	No	0	8	8
34	R:R:D122	R:R:F63	52.1779	4.78	No	Yes	0	9	8
35	R:R:D122	R:R:R137	49.4018	3.57	No	No	0	9	8
36	R:R:R137	R:R:V59	43.3742	10.46	No	Yes	0	8	7
37	R:R:T58	R:R:V59	23.8267	1.59	No	Yes	0	8	7
38	R:R:N61	R:R:T58	20.4678	4.39	No	No	0	9	8
39	R:R:L56	R:R:N61	17.0936	2.75	Yes	No	0	9	9
40	R:R:F63	R:R:I146	39.7929	5.02	Yes	Yes	0	8	9
41	R:R:P139	R:R:V59	10.2991	3.53	No	Yes	0	5	7
42	R:R:F63	R:R:L118	12.7301	6.09	Yes	No	0	8	7
43	R:R:F63	R:R:I119	11.8635	5.02	Yes	No	0	8	9
44	L:L:?1	R:R:W378	60.6748	17.34	Yes	Yes	1	0	8
45	R:R:N410	R:R:W378	31.7255	7.91	No	Yes	1	9	8
46	R:R:N410	R:R:N414	29.1948	5.45	No	Yes	1	9	9
47	R:R:I161	R:R:Y106	37.3773	9.67	Yes	Yes	1	7	8
48	R:R:A103	R:R:I161	79.8006	3.25	No	Yes	0	8	7
49	R:R:A103	R:R:L162	77.3313	4.73	No	No	0	8	6
50	R:R:D99	R:R:L162	49.4632	8.14	No	No	0	7	6
51	R:R:D99	R:R:L100	47.2776	6.79	No	No	0	7	6
52	R:R:L100	R:R:W101	44.5936	2.28	No	No	0	6	7
53	R:R:I161	R:R:W157	46.7791	4.7	Yes	Yes	1	7	8
54	R:R:A97	R:R:W101	34.1334	7.78	No	No	0	6	7
55	R:R:A97	R:R:T95	31.3727	1.68	No	No	0	6	4
56	R:R:T95	R:R:W91	25.8052	31.53	No	No	0	4	9
57	R:R:W91	R:R:Y85	22.9985	1.93	No	Yes	0	9	7
58	R:R:Q177	R:R:Y85	11.6181	11.27	No	Yes	0	4	7
59	R:R:L156	R:R:W157	31.6028	3.42	No	Yes	1	8	8
60	R:R:F374	R:R:W378	29.1411	22.05	Yes	Yes	1	9	8
61	R:R:F374	R:R:V113	18.6196	2.62	Yes	No	0	9	9
62	R:R:P200	R:R:V113	16.0046	3.53	No	No	0	9	9
63	R:R:L156	R:R:V152	42.4387	2.98	No	No	0	8	5
64	R:R:M114	R:R:V152	39.0184	3.04	No	No	0	7	5
65	R:R:L117	R:R:M114	35.5368	5.65	No	No	0	7	7
66	R:R:I370	R:R:N414	19.2101	7.08	Yes	Yes	0	8	9
67	R:R:F121	R:R:L117	33.7577	2.44	Yes	No	0	7	7
68	R:R:F121	R:R:L207	26.8558	7.31	Yes	No	0	7	8
69	R:R:L207	R:R:Y124	25.0153	10.55	No	No	0	8	8
70	R:R:T128	R:R:Y124	19.4018	8.74	No	No	0	8	8
71	R:R:F163	R:R:L162	28.1058	9.74	No	No	0	6	6
72	R:R:F163	R:R:Y166	25.3144	7.22	No	No	0	6	5
73	R:R:Q165	R:R:Y166	22.5077	13.53	No	No	0	7	5
74	R:R:Q165	R:R:V173	19.6856	4.3	No	Yes	0	7	4
75	R:R:Q181	R:R:V173	11.1273	2.87	No	Yes	0	8	4
76	L:L:?1	R:R:N382	45.8436	3.98	Yes	No	1	0	8
77	R:R:N382	R:R:Y198	26.9402	11.63	No	Yes	1	8	7
78	R:R:L386	R:R:Y198	18.8727	11.72	No	Yes	1	7	7
79	R:R:F390	R:R:L386	16.319	2.44	No	No	0	5	7
80	R:R:F390	R:R:T389	13.5736	3.89	No	No	0	5	8
81	R:R:P186	R:R:T389	10.8129	1.75	No	No	0	5	8
82	R:R:F197	R:R:N382	16.9095	22.96	Yes	No	1	9	8
83	R:R:C417	R:R:I370	11.066	3.27	No	Yes	0	8	8
84	L:L:?1	R:R:Y381	24.5169	6.8	Yes	Yes	1	0	8
85	R:R:W400	R:R:Y381	20.3374	7.72	Yes	Yes	1	7	8
86	R:R:V395	R:R:W400	12.1702	4.9	No	Yes	1	6	7
87	R:R:V409	R:R:W405	17.0169	7.36	No	No	0	7	8
88	R:R:L406	R:R:V409	12.7837	2.98	No	No	0	8	7
89	R:R:W157	R:R:Y106	25.5061	13.5	Yes	Yes	1	8	8
90	R:R:L156	R:R:N110	12.5153	6.87	No	No	1	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y106	5.1	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:S109	8.71	1	Yes	No	0	8	0	1
L:L:?1	R:R:W157	5.78	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:T192	4.27	1	Yes	No	0	8	0	1
L:L:?1	R:R:A196	5.71	1	Yes	No	0	8	0	1
L:L:?1	R:R:W378	17.34	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y381	6.8	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:N382	3.98	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y404	11.05	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:C407	8.05	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y408	6.8	1	Yes	Yes	0	8	0	1
R:R:D105	R:R:S78	11.78	1	Yes	No	9	8	2	2
R:R:S78	R:R:Y408	5.09	1	No	Yes	8	8	2	1
R:R:Y404	R:R:Y82	10.92	1	Yes	Yes	7	7	1	2
R:R:Y408	R:R:Y82	8.94	1	Yes	Yes	8	7	1	2
R:R:D105	R:R:Y106	4.6	1	Yes	Yes	9	8	2	1
R:R:D105	R:R:Y408	12.64	1	Yes	Yes	9	8	2	1
R:R:W157	R:R:Y106	13.5	1	Yes	Yes	8	8	1	1
R:R:I161	R:R:Y106	9.67	1	Yes	Yes	7	8	2	1
R:R:I180	R:R:Y106	9.67	1	Yes	Yes	7	8	2	1
R:R:L183	R:R:Y106	4.69	1	No	Yes	7	8	2	1
R:R:L156	R:R:N110	6.87	1	No	No	8	8	2	2
R:R:N110	R:R:W157	14.69	1	No	Yes	8	8	2	1
R:R:L156	R:R:W157	3.42	1	No	Yes	8	8	2	1
R:R:I161	R:R:W157	4.7	1	Yes	Yes	7	8	2	1
R:R:F182	R:R:W157	5.01	1	Yes	Yes	6	8	2	1
R:R:I161	R:R:I180	5.89	1	Yes	Yes	7	7	2	2
R:R:F182	R:R:I161	3.77	1	Yes	Yes	6	7	2	2
R:R:F182	R:R:I180	11.3	1	Yes	Yes	6	7	2	2
R:R:I180	R:R:L183	7.14	1	Yes	No	7	7	2	2
R:R:F182	R:R:L183	3.65	1	Yes	No	6	7	2	2
R:R:F197	R:R:Y198	8.25	1	Yes	Yes	9	7	2	2
R:R:F197	R:R:F374	7.5	1	Yes	Yes	9	9	2	2
R:R:F197	R:R:N382	22.96	1	Yes	No	9	8	2	1
R:R:N382	R:R:Y198	11.63	1	No	Yes	8	7	1	2
R:R:F374	R:R:W378	22.05	1	Yes	Yes	9	8	2	1
R:R:T377	R:R:W378	6.06	1	No	Yes	8	8	2	1
R:R:N410	R:R:T377	4.39	1	No	No	9	8	2	2
R:R:N410	R:R:W378	7.91	1	No	Yes	9	8	2	1
R:R:V385	R:R:Y381	3.79	1	Yes	Yes	8	8	2	1
R:R:W400	R:R:Y381	7.72	1	Yes	Yes	7	8	2	1
R:R:Y381	R:R:Y404	9.93	1	Yes	Yes	8	7	1	1
R:R:V385	R:R:W400	3.68	1	Yes	Yes	8	7	2	2
R:R:Y404	R:R:Y408	8.94	1	Yes	Yes	7	8	1	1
R:R:S109	R:R:S112	1.63	0	No	No	8	9	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9UAZ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.25
Number of Linked Nodes	229
Number of Links	248
Number of Hubs	33
Number of Links mediated by Hubs	127
Number of Communities	1
Number of Nodes involved in Communities	38
Number of Links involved in Communities	62

Path Summary
Number Of Nodes in MetaPath	91
Number Of Links MetaPath	90
Number of Shortest Paths	40481
Length Of Smallest Path	3
Average Path Length	12.7657
Length of Longest Path	29
Minimum Path Strength	1.38
Average Path Strength	6.70123
Maximum Path Strength	19.695
Minimum Path Correlation	0.7
Average Path Correlation	0.907277
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	44.0021
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.6755
Maximum Path Hubs %	100

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P11229
Sequence	>9UAZ_nogp_Chain_R W Q V A F I G I T T G L L S L A T V T G N L L V L I S F K V N T E L K T V N N Y F L L S L A C A D L I I G T F S M N L Y T T Y L L M G H W A L G T L A C D L W L A L D Y V A S N A S V M N L L L I S F D R Y F S V T R P L S Y R A K R T P R R A A L M I G L A W L V S F V L W A P A I L F W Q Y L E R T V L A G Q C Y I Q F L S Q P I I T F G T A M A A F Y L P V T V M C T L Y W R I Y R K E K K A A R T L S A I L L A F I L T W T P Y N I M V L V S T F C K D C V P E T L W E L G Y W L C Y V N S T I N P M C Y A L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4ZUD	A	Peptide	Angiotensin	AT₁	Homo sapiens	Olmesartan	-	-	2.8	2015-10-07	doi.org/10.1074/jbc.M115.689000
	5CXV	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	Tiotropium	-	-	2.7	2016-03-09	doi.org/10.1038/nature17188
	5XR8	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM12033	-	-	2.95	2017-07-12	doi.org/10.1038/nature23272
	5XRA	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM11542	-	-	2.8	2017-07-12	doi.org/10.1038/nature23272
	5OM1	A	Nucleotide	Adenosine	A_2A	Homo sapiens	PubChem 135566609	Na	-	2.1	2018-01-17	doi.org/10.1038/s41598-017-18570-w
	5ZTY	A	Lipid	Cannabinoid	CB₂	Homo sapiens	AM10257	-	-	2.8	2019-01-30	doi.org/10.1016/j.cell.2018.12.011
	6OIJ	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	Iperoxo	-	chim(NtGi1L-G11)/β1/γ2	3.3	2019-05-08	doi.org/10.1126/science.aaw5188
	6OIJ (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	Iperoxo	-		3.3	2019-05-08	doi.org/10.1126/science.aaw5188
	6KPC	A	Lipid	Cannabinoid	CB₂	Homo sapiens	AM12033	-	-	3.2	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPF	A	Lipid	Cannabinoid	CB₂	Homo sapiens	AM12033	-	Gi1/β1/γ2	2.9	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPF (No Gprot)	A	Lipid	Cannabinoid	CB₂	Homo sapiens	AM12033	-		2.9	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6M1H	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	Maxadilan	-	Gs/β1/γ2	3.6	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	6M1H (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	Maxadilan	-		3.6	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	6M1I	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-	Gs/β1/γ2	3.5	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	6M1I (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-		3.5	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	6UUN	B1	Peptide	Calcitonin	CT Like (AM1)	Homo sapiens	Adrenomedullin	-	Gs/β1/γ2; RAMP2	3	2020-03-25	doi.org/10.1021/acsptsci.9b00080
	6UUN (No Gprot)	B1	Peptide	Calcitonin	CT Like (AM1)	Homo sapiens	Adrenomedullin	-		3	2020-03-25	doi.org/10.1021/acsptsci.9b00080
	6WJC	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	Atropine	Muscarinic toxin 7	-	2.55	2020-07-08	doi.org/10.1126/science.aax2517
	6ZFZ	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	77-LH-28-1	-	-	2.17	2021-10-06	doi.org/10.1016/j.cell.2021.11.001
	6ZG4	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	HTL0009936	-	-	2.33	2021-10-06	doi.org/10.1016/j.cell.2021.11.001
	6ZG9	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	GSK1034702	-	-	2.5	2021-10-06	doi.org/10.1016/j.cell.2021.11.001
	9M1H	A	Lipid	Prostanoid	EP₁	Homo sapiens	PGE2	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.55	2025-04-09	doi.org/10.1073/pnas.2423840122
	9M1H (No Gprot)	A	Lipid	Prostanoid	EP₁	Homo sapiens	PGE2	-		2.55	2025-04-09	doi.org/10.1073/pnas.2423840122
	9BUY	A	Amine	Adrenergic	β₂	Homo sapiens	LM189	-	Gi1/β1/γ2	2.9	2025-05-28	doi.org/10.1126/sciadv.adq3971
	9BUY (No Gprot)	A	Amine	Adrenergic	β₂	Homo sapiens	LM189	-		2.9	2025-05-28	doi.org/10.1126/sciadv.adq3971
	9JEA	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	Atropine	-	-	3.4	2025-07-09	To be published
	9JEA (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	Atropine	-		3.4	2025-07-09	To be published
	9M1O	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Neuropeptide-FF	-	Gi1/β1/γ2	2.49	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M1O (No Gprot)	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Neuropeptide-FF	-		2.49	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9UAP	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	-	-	G11(CT)	3.62	2025-10-29	To be published
	9UAP (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	-	-		3.62	2025-10-29	To be published
	9UAZ	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	Atropine	-	-	3.29	2025-10-29	To be published
	9UAZ (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	Atropine	-		3.29	2025-10-29	To be published
	9UCP	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	Iperoxo	-	G11(CT)	2.88	2025-10-29	To be published
	9UCP (No Gprot)	A	Amine	Acetylcholine (muscarinic)	M₁	Homo sapiens	Iperoxo	-		2.88	2025-10-29	To be published

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Data downloads are temporarily suspended for technical reasons. We apologize for the inconvenience.

Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.