Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:V34 5.5054235
2A:A:L37 4.3225449
3A:A:L38 4.1875408
4A:A:K46 3.824509
5A:A:F191 8.214245
6A:A:K197 8.2085126
7A:A:F199 9.64125
8A:A:Q204 5.5325449
9A:A:R208 5.088549
10A:A:K210 4.80833649
11A:A:W211 5.54429749
12A:A:F215 6.59549
13A:A:S228 3.0325499
14A:A:D229 5.2475498
15A:A:Y230 9.9975498
16A:A:S246 3.32254139
17A:A:F250 4.586676139
18A:A:N255 7.684258
19A:A:W258 7.67675
20A:A:N269 5.28409
21A:A:F274 8.0575499
22A:A:I278 6.4325496
23A:A:C286 3.9325406
24A:A:Y287 7.2075407
25A:A:Y296 8.0154264
26A:A:E298 5.194194
27A:A:F307 3.9345138
28A:A:Y320 3.70754187
29A:A:F323 5.6354264
30A:A:N331 2.76408
31A:A:F336 5.69254248
32B:B:V40 5.03754203
33B:B:R48 5.61437
34B:B:R49 6.9075437
35B:B:L51 5.614539
36B:B:H54 9.22167639
37B:B:Y59 5.782578
38B:B:M61 4.005406
39B:B:W63 7.214507
40B:B:D76 5.896539
41B:B:K78 4.6525408
42B:B:I81 3.24254307
43B:B:W82 9.532539
44B:B:D83 7.5438
45B:B:S84 3.19435
46B:B:Y85 9.406534
47B:B:N88 4.7225437
48B:B:K89 6.08639
49B:B:H91 4.32754305
50B:B:I93 6.9425407
51B:B:L95 4.474318
52B:B:W99 8.345609
53B:B:Y105 3.58506
54B:B:Y124 4.46506
55B:B:T128 3.7065213
56B:B:E130 5.02754213
57B:B:H142 7.22714789
58B:B:Y145 4.54571748
59B:B:L146 3.765487
60B:B:R150 5.015416
61B:B:F151 5.532509
62B:B:L152 4.2725413
63B:B:N155 5.668513
64B:B:Q156 5.085615
65B:B:T159 6.155489
66B:B:D163 8.036589
67B:B:A167 2.8825484
68B:B:L168 5.3275416
69B:B:W169 10.3617688
70B:B:D170 7.4925419
71B:B:T177 4.4225414
72B:B:F180 9.135417
73B:B:H183 8.95619
74B:B:V187 4.74419
75B:B:L190 2.66415
76B:B:L192 4.26515
77B:B:R197 7.035425
78B:B:F199 8.0875419
79B:B:V200 5.5025426
80B:B:S201 4.2975419
81B:B:D205 6.618519
82B:B:K209 10.088516
83B:B:L210 5.31425
84B:B:W211 9.764518
85B:B:D212 5.5625429
86B:B:F222 6.45333628
87B:B:H225 8.95629
88B:B:I232 4.395428
89B:B:F234 5.8525405
90B:B:F235 10.23456
91B:B:P236 7.494557
92B:B:F241 7.01429726
93B:B:T243 5.08167628
94B:B:S245 6.5925429
95B:B:D247 6.1875429
96B:B:T249 5.555426
97B:B:R251 11.35528
98B:B:L252 3.215407
99B:B:F253 6.284526
100B:B:D254 4.3525409
101B:B:Y264 7.13655
102B:B:H266 8.875454
103B:B:I269 3.0825404
104B:B:F278 6.615657
105B:B:R283 7.273336209
106B:B:Y289 4.82167657
107B:B:D290 8.335476
108B:B:N295 9.24456
109B:B:V296 3.12405
110B:B:W297 7.876558
111B:B:D298 8.90754209
112B:B:H311 9.6745119
113B:B:R314 10.3625478
114B:B:L318 2.978506
115B:B:W332 7.89571779
116B:B:D333 10.434119
117B:B:L336 3.6975407
118B:B:K337 5.29254116
119B:B:I338 4.1275435
120B:B:W339 8.8054119
121B:B:N340 5.1775439
122G:G:Y40 12.94456
123G:G:D48 6.668559
124G:G:L51 2.7925406
125G:G:N59 4.962539
126G:G:P60 4.94439
127G:G:F61 4.56875838
128R:R:E37 4.346507
129R:R:F38 7.84106
130R:R:H55 4.0425405
131R:R:S62 4.9554148
132R:R:L69 4.506569
133R:R:D73 6.074569
134R:R:I77 7.29254105
135R:R:F82 5.505406
136R:R:V83 4.28754106
137R:R:D85 5.8054154
138R:R:R89 6.9725154
139R:R:W93 10.9725159
140R:R:K94 7.695403
141R:R:G96 1.8354228
142R:R:F107 8.8254106
143R:R:Q112 8.2765167
144R:R:I115 4.9275468
145R:R:F117 8407
146R:R:Y126 7.587178
147R:R:R128 6.8425148
148R:R:V130 8.2154177
149R:R:P132 5.9575408
150R:R:H133 6.3575405
151R:R:W152 5.5125409
152R:R:T155 4.254167
153R:R:T159 3.4945326
154R:R:I182 4.1525402
155R:R:P200 3.265469
156R:R:R210 5.79754174
157R:R:M220 4.0254273
158R:R:H223 8.7354273
159R:R:F232 8.23467
160R:R:V236 4.945467
161R:R:F240 5.698569
162R:R:F244 8.548569
163R:R:R251 5.2525406
164R:R:L257 2.42833602
165R:R:F277 4.194505
166R:R:T279 5.18254336
167R:R:F282 6.1585337
168R:R:Y284 9.605407
169R:R:D290 8.752569
170R:R:Y294 6.586569
171R:R:Y295 7.6375465
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:W332 B:B:Y59 29.33995.79YesYes798
2B:B:S316 B:B:W332 11.96934.94NoYes099
3B:B:C317 B:B:S316 11.88713.44NoNo079
4B:B:C317 B:B:M61 11.81516.48NoYes076
5A:A:I222 A:A:L38 98.76222.85NoYes078
6A:A:K46 A:A:L38 1004.23YesYes098
7A:A:G40 A:A:K46 99.30423.49NoYes099
8A:A:G40 A:A:L39 99.4151.71NoNo099
9A:A:L37 A:A:L39 61.49664.15YesNo099
10A:A:F215 A:A:L37 61.4587.31YesYes499
11A:A:C214 A:A:F215 29.05176.98NoYes079
12A:A:C214 B:B:Y59 29.00122.69NoYes078
13A:A:I253 A:A:L39 38.1775.71NoNo089
14A:A:I253 A:A:R208 38.0335.01NoYes489
15A:A:R208 A:A:W211 54.78994YesYes499
16A:A:F215 A:A:W211 45.50884.01YesYes499
17A:A:F267 A:A:H322 98.02152.26NoNo099
18A:A:F267 A:A:I222 98.24713.77NoNo097
19A:A:Q204 B:B:N119 23.44667.92YesNo099
20A:A:Q204 A:A:W211 45.39034.38YesYes499
21A:A:F191 A:A:Q333 96.53042.34YesNo055
22A:A:K330 A:A:Q333 96.77826.78NoNo045
23A:A:F334 A:A:K330 94.07092.48NoNo034
24A:A:F334 A:A:H322 95.052911.31NoNo039
25A:A:F191 A:A:F336 96.11166.43YesYes2458
26A:A:F336 A:A:L194 46.5683.65YesNo084
27A:A:L194 R:R:H133 46.41965.14NoYes045
28A:A:F336 A:A:T340 49.46786.49YesNo086
29A:A:T340 R:R:H133 46.79624.11NoYes065
30A:A:W211 B:B:L117 22.42964.56YesNo499
31A:A:Q204 B:B:Y145 22.75134.51YesYes498
32A:A:S206 A:A:W211 22.73746.18NoYes489
33A:A:S206 B:B:Y145 22.3177.63NoYes488
34B:B:L117 B:B:Y145 22.30043.52NoYes498
35A:A:K210 B:B:Y145 66.0455.97YesYes498
36A:A:L249 A:A:R208 16.80743.64NoYes499
37A:A:K210 B:B:D228 64.03225.53YesNo499
38A:A:F223 A:A:L249 16.853.65NoNo099
39A:A:F223 A:A:F250 16.721510.72NoYes099
40A:A:F323 A:A:Q304 14.53234.68YesNo045
41A:A:L283 A:A:Y230 11.182112.89NoYes978
42B:B:R314 B:B:W332 18.033117.99YesYes789
43R:R:H133 R:R:P132 92.571612.2YesYes058
44A:A:N347 R:R:P132 85.14861.63NoYes088
45A:A:N347 R:R:R128 84.47913.62NoYes1488
46A:A:C351 R:R:S62 82.22056.89NoYes048
47R:R:R128 R:R:S62 83.15872.64YesYes1488
48A:A:C351 R:R:R125 81.89436.96NoNo049
49B:B:D290 B:B:R314 13.918117.87YesYes768
50B:B:C271 B:B:D290 14.45227.78NoYes056
51B:B:C271 B:B:Y289 13.69895.38NoYes057
52B:B:I273 B:B:Y289 10.24979.67NoYes067
53B:B:G244 B:B:I273 10.18333.53NoNo056
54B:B:G244 B:B:T243 10.1233.64NoYes058
55B:B:F241 B:B:T243 22.46792.59YesYes268
56B:B:D258 B:B:F222 34.7978.36NoYes278
57B:B:D258 B:B:R22 33.179611.91NoNo076
58B:B:F222 B:B:F253 30.11214.29YesYes286
59B:B:Q259 B:B:R22 21.47458.18NoNo066
60B:B:A26 B:B:Q259 15.61973.03NoNo036
61B:B:A26 G:G:V30 13.66781.7NoNo038
62G:G:S31 G:G:V30 11.71583.23NoNo098
63B:B:C148 B:B:R150 12.87312.79NoYes066
64B:B:C148 B:B:T102 13.02873.38NoNo068
65B:B:C149 B:B:T102 13.20683.38NoNo088
66B:B:C121 B:B:C149 13.6693.64NoNo088
67B:B:G144 B:B:N119 22.87873.39NoNo089
68B:B:D163 B:B:G144 22.74175.03YesNo098
69B:B:D163 B:B:H142 22.15857.56YesYes899
70B:B:L210 B:B:V200 10.56422.98YesYes256
71B:B:H225 B:B:T243 33.19128.21YesYes298
72B:B:H225 B:B:S245 43.202512.55YesYes299
73B:B:F253 B:B:R251 22.61525.34YesYes268
74B:B:D228 B:B:D246 63.71856.65NoNo099
75B:B:D246 B:B:S227 62.99768.83NoNo096
76B:B:S227 B:B:S245 52.6743.26NoYes269
77R:R:F232 R:R:R125 80.876717.1YesNo679
78R:R:F232 R:R:V236 79.93393.93YesYes677
79R:R:L118 R:R:V236 71.05397.45NoYes687
80R:R:F240 R:R:L118 71.03967.31YesNo698
81R:R:F240 R:R:I115 64.48363.77YesYes698
82R:R:I115 R:R:R111 64.35993.76YesNo087
83R:R:Q112 R:R:R111 64.02511.68YesNo077
84R:R:E196 R:R:Q112 16.95277.65NoYes1667
85R:R:E196 R:R:F193 16.6072.33NoNo065
86R:R:F193 R:R:R251 16.24972.14NoYes056
87R:R:I254 R:R:R251 13.02617.52NoYes056
88R:R:I254 R:R:L257 12.3082.85NoYes052
89R:R:Q112 R:R:T155 42.12818.5YesYes1677
90R:R:T155 R:R:W152 41.44793.64YesYes079
91R:R:M109 R:R:W152 30.35463.49NoYes059
92R:R:L75 R:R:M109 27.15258.48NoNo065
93R:R:L75 R:R:M106 22.86865.65NoNo065
94R:R:C79 R:R:M106 22.55793.24NoNo065
95R:R:C79 R:R:F82 22.20598.38NoYes066
96R:R:F82 R:R:V103 10.82065.24YesNo065
97R:R:F107 R:R:V103 10.46173.93YesNo065
98R:R:F82 R:R:V83 10.82532.62YesYes066
99R:R:V83 R:R:Y86 10.56886.31YesNo065
100B:B:R251 B:B:T249 17.89217.76YesYes286
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9JIC
Class A
SubFamily Alicarboxylic acid
Type Hydroxycarboxylic Acid
SubType HCA3
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.4
Date 2025-12-17
D.O.I. 10.1016/j.celrep.2024.114895
Net Summary
Imin 2.43
Number of Linked Nodes 815
Number of Links 1000
Number of Hubs 171
Number of Links mediated by Hubs 626
Number of Communities 33
Number of Nodes involved in Communities 253
Number of Links involved in Communities 354
Path Summary
Number Of Nodes in MetaPath 101
Number Of Links MetaPath 100
Number of Shortest Paths 1796739
Length Of Smallest Path 3
Average Path Length 37.3027
Length of Longest Path 68
Minimum Path Strength 1.345
Average Path Strength 5.79505
Maximum Path Strength 21.87
Minimum Path Correlation 0.73
Average Path Correlation 0.988426
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.63158
Average % Of Corr. Nodes 40.7115
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.32
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development
Gene OntologyBiological Process• multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • D2 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • neuropeptide signaling pathway   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • response to peptide hormone   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • cell surface receptor signaling pathway   • response to cytokine   • response to chemokine   • cytokine-mediated signaling pathway   • cellular response to chemokine   • chemokine-mediated signaling pathway   • response to peptide   • cellular response to cytokine stimulus   • multicellular organismal process   • system process   • relaxation of smooth muscle   • regulation of system process   • regulation of muscle system process   • muscle system process   • relaxation of muscle   • positive regulation of relaxation of smooth muscle   • positive regulation of relaxation of muscle   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • regulation of relaxation of smooth muscle   • regulation of relaxation of muscle   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • localization   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • sperm principal piece   • 9+2 motile cilium   • sperm flagellum   • motile cilium   • nucleoplasm   • Golgi apparatus   • endomembrane system   • ciliary basal body   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • nicotinic acid receptor activity   • negative regulation of catabolic process   • lipid catabolic process   • catabolic process   • negative regulation of metabolic process   • regulation of catabolic process   • regulation of lipid catabolic process   • negative regulation of lipid metabolic process   • negative regulation of lipid catabolic process
SCOP2Domain Identifier• Ras-like P-loop GTPases
SCOP2Family Identifier• Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>9JIC_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKST 
IVKQMTGIV ETHFTFKDL HFKMFDVGA QRSERKKWI HCFEGVTAI 
IFCVALSDY DLVNRMHES MKLFDSICN NKWFTDTSI ILFLNKKDL 
FEEKIKKSP LTICYPEYA GSNTYEEAA AYIQCQFED LNKRKDTKE 
IYTHFTCST DTKNVQFVF DAVTDVIIK NNLKDC


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9JIC_Chain_B
EAEQLKNQI RDARKACAD ATLSQITNN IDPVGRIQM RTRRTLRGH 
LAKIYAMHW GTDSRLLVS ASQDGKLII WDSYTTNKV HAIPLRSSW 
VMTCAYAPS GNYVACGGL DNICSIYNL KTREGNVRV SRELAGHTG 
YLSCCRFLD DNQIVTSSG DTTCALWDI ETGQQTTTF TGHTGDVMS 
LSLAPDTRL FVSGACDAS AKLWDVREG MCRQTFTGH ESDINAICF 
FPNGNAFAT GSDDATCRL FDLRADQEL MTYSHDNII CGITSVSFS 
KSGRLLLAG YDDFNCNVW DALKADRAG VLAGHDNRV SCLGVTDDG 
MAVATGSWD SFLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9JIC_Chain_G
RIKVSKAAA DLMAYCEAH AKEDPLLTP VPASENPFR E


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP49019
Sequence
>9JIC_Chain_R
CCVFRDDFI AKVLPPVLG LEFIFGLLG NGLALWIFC FHLKSWKSS 
RIFLFNLAV ADFLLIICL PFVMDYYVR RSDWKFGDI PCRLVLFMF 
AMNRQGSII FLTVVAVDR YFRVVHPHH ALNKISNWT AAIISCLLW 
GITVGLTVH LLKQNGTAN VCISFSICF RWHEAMFLL EFFLPLGII 
LFCSARIIW SLRQRQMDR HAKIKRAIT FIMVVAIVF VICFLPSVV 
VRIHIFWLL HTSTQNCEV YRSVDLAFF ITLSFTYMN SMLDPVVYY 
FSSPS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IHJAAlicarboxylic acidHydroxycarboxylic AcidHCA3Homo sapiensAcifran-Gi1/β1/γ23.072023-08-30doi.org/10.1038/s41467-023-41650-7
8IHJ (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA3Homo sapiensAcifran-3.072023-08-30doi.org/10.1038/s41467-023-41650-7
8IHKAAlicarboxylic acidHydroxycarboxylic AcidHCA3Homo sapiensAcifran--3.212023-08-30doi.org/10.1038/s41467-023-41650-7
9JKSAAlicarboxylic acidHydroxycarboxylic AcidHCA3Homo sapiensPubChem 44250176-Gi1/β1/γ23.312025-10-29To be published
9JKS (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA3Homo sapiensPubChem 44250176-3.312025-10-29To be published
9JKTAAlicarboxylic acidHydroxycarboxylic AcidHCA3Homo sapiens(2R)-2-hydroxy-3-phenylpropanoic acid-Gi1/β1/γ23.052025-10-29To be published
9JKT (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA3Homo sapiens(2R)-2-hydroxy-3-phenylpropanoic acid-3.052025-10-29To be published
9JKVAAlicarboxylic acidHydroxycarboxylic AcidHCA3Homo sapiensPubChem 2736690-Gi1/β1/γ23.262025-10-29To be published
9JKV (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA3Homo sapiensPubChem 2736690-3.262025-10-29To be published
9JKXAAlicarboxylic acidHydroxycarboxylic AcidHCA3Homo sapiensAcifran-Gi1/β1/γ23.182025-10-29To be published
9JKX (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA3Homo sapiensAcifran-3.182025-10-29To be published
8JEFAAlicarboxylic acidHydroxycarboxylic AcidHCA3Homo sapiensPubChem 11367166-Gi1/β1/γ22.962024-12-18doi.org/10.1016/j.celrep.2024.114895
8JEF (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA3Homo sapiensPubChem 11367166-2.962024-12-18doi.org/10.1016/j.celrep.2024.114895
9KT6AAlicarboxylic acidHydroxycarboxylic AcidHCA3Homo sapiensAcifran-Gi1/β1/γ23.012025-12-1010.1021/acs.jmedchem.4c02567
9KT6 (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA3Homo sapiensAcifran-3.012025-12-1010.1021/acs.jmedchem.4c02567
9JIC (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA3Homo sapiens--3.42025-12-1710.1016/j.celrep.2024.114895
9JIDAAlicarboxylic acidHydroxycarboxylic AcidHCA3Homo sapiensNiacin-Gi1/β1/γ22.782025-12-1710.1016/j.celrep.2024.114895
9JID (No Gprot) AAlicarboxylic acidHydroxycarboxylic AcidHCA3Homo sapiensNiacin-2.782025-12-1710.1016/j.celrep.2024.114895




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9JIC.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.