psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y86	14.13	Yes	Yes	1	0	5
2	L:L:?1	R:R:L104	6.42	Yes	Yes	0	0	5
3	L:L:?1	R:R:F107	45.17	Yes	Yes	1	0	6
4	L:L:?1	R:R:R111	9.01	Yes	No	0	0	7
5	L:L:?1	R:R:Y284	13.04	Yes	Yes	1	0	7
6	R:R:C18	R:R:N17	11.02	No	No	6	8	6
7	R:R:C183	R:R:N17	6.3	Yes	No	6	1	6
8	R:R:C18	R:R:S181	3.44	No	No	6	8	5
9	R:R:C18	R:R:C183	7.28	No	Yes	6	8	1
10	R:R:C19	R:R:F21	4.19	No	Yes	7	3	3
11	R:R:C19	R:R:C266	7.28	No	No	7	3	6
12	R:R:I178	R:R:V20	4.61	No	No	0	3	2
13	R:R:C266	R:R:F21	4.19	No	Yes	7	6	3
14	R:R:F21	R:R:R270	13.9	Yes	No	0	3	2
15	R:R:D273	R:R:F21	5.97	No	Yes	0	4	3
16	R:R:I26	R:R:R22	6.26	Yes	Yes	1	4	5
17	R:R:R22	R:R:Y86	3.09	Yes	Yes	1	5	5
18	R:R:R22	R:R:Y87	7.2	Yes	Yes	1	5	5
19	R:R:R22	R:R:R90	3.2	Yes	No	1	5	3
20	R:R:R22	R:R:S91	9.22	Yes	No	1	5	4
21	R:R:F277	R:R:R22	5.34	No	Yes	1	5	5
22	R:R:D23	R:R:D24	10.65	No	No	0	5	4
23	R:R:F25	R:R:V29	7.87	No	No	0	5	4
24	R:R:F25	R:R:L274	3.65	No	No	0	5	3
25	R:R:I26	R:R:L30	4.28	Yes	No	0	4	6
26	R:R:I26	R:R:Y87	6.04	Yes	Yes	1	4	5
27	R:R:F277	R:R:I26	6.28	No	Yes	1	5	4
28	R:R:L30	R:R:L34	4.15	No	No	0	6	8
29	R:R:P31	R:R:P32	5.84	No	No	0	6	4
30	R:R:E37	R:R:V33	5.7	No	No	0	7	6
31	R:R:L34	R:R:V83	5.96	No	Yes	0	8	6
32	R:R:L34	R:R:M84	5.65	No	No	0	8	7
33	R:R:E37	R:R:M288	5.41	No	No	0	7	6
34	R:R:F38	R:R:L42	6.09	No	No	0	6	6
35	R:R:F38	R:R:P81	2.89	No	No	0	6	9
36	R:R:I39	R:R:L43	2.85	No	No	0	5	4
37	R:R:I77	R:R:L42	2.85	Yes	No	0	5	6
38	R:R:F296	R:R:G44	3.01	No	No	0	7	7
39	R:R:D73	R:R:N45	12.12	No	Yes	0	9	9
40	R:R:I77	R:R:N45	7.08	Yes	Yes	0	5	9
41	R:R:N45	R:R:P291	6.52	Yes	No	0	9	9
42	R:R:I51	R:R:L47	2.85	No	No	0	7	5
43	R:R:F67	R:R:L49	3.65	Yes	No	0	6	7
44	R:R:F74	R:R:L49	7.31	No	No	0	7	7
45	R:R:F54	R:R:W50	17.04	No	No	0	4	4
46	R:R:F301	R:R:I51	5.02	No	No	0	8	7
47	R:R:F52	R:R:W59	3.01	No	No	3	7	6
48	R:R:F52	R:R:F67	11.79	No	Yes	3	7	6
49	R:R:F52	R:R:Y295	6.19	No	Yes	3	7	5
50	R:R:C53	R:R:F54	8.38	No	No	0	2	4
51	R:R:F301	R:R:H55	3.39	No	No	0	8	5
52	R:R:I64	R:R:W59	3.52	No	No	0	6	6
53	R:R:F67	R:R:W59	4.01	Yes	No	3	6	6
54	R:R:I139	R:R:S61	4.64	No	No	0	7	7
55	R:R:A144	R:R:S61	3.42	No	No	0	8	7
56	R:R:D124	R:R:S62	5.89	No	No	0	8	8
57	R:R:A144	R:R:I64	6.5	No	No	0	8	6
58	R:R:F65	R:R:V120	6.55	No	No	0	6	6
59	R:R:L66	R:R:V121	2.98	No	No	0	8	8
60	R:R:L66	R:R:Y294	3.52	No	Yes	3	8	9
61	R:R:L66	R:R:Y295	7.03	No	Yes	3	8	5
62	R:R:F67	R:R:N68	4.83	Yes	No	0	6	9
63	R:R:F67	R:R:V71	6.55	Yes	No	0	6	5
64	R:R:F117	R:R:N68	12.08	No	No	0	7	9
65	R:R:N68	R:R:S148	7.45	No	No	0	9	6
66	R:R:L118	R:R:L69	4.15	No	No	0	8	9
67	R:R:D290	R:R:L69	9.5	Yes	No	0	9	9
68	R:R:L69	R:R:Y295	3.52	No	Yes	0	9	5
69	R:R:A70	R:R:Y295	4	No	Yes	0	8	5
70	R:R:D73	R:R:S287	5.89	No	No	0	9	8
71	R:R:D290	R:R:D73	3.99	Yes	No	0	9	9
72	R:R:F74	R:R:I77	7.54	No	Yes	0	7	5
73	R:R:F74	R:R:I78	7.54	No	No	0	7	4
74	R:R:L75	R:R:M106	4.24	No	No	5	6	5
75	R:R:L75	R:R:N110	6.87	No	Yes	5	6	8
76	R:R:L76	R:R:N110	4.12	No	Yes	0	6	8
77	R:R:L76	R:R:Y284	4.69	No	Yes	0	6	7
78	R:R:L76	R:R:S287	6.01	No	No	0	6	8
79	R:R:I77	R:R:L80	2.85	Yes	No	0	5	8
80	R:R:C79	R:R:M106	3.24	No	No	0	6	5
81	R:R:L80	R:R:V83	2.98	No	Yes	0	8	6
82	R:R:L80	R:R:Y284	3.52	No	Yes	0	8	7
83	R:R:F82	R:R:P81	4.33	No	No	0	6	9
84	R:R:D85	R:R:F82	3.58	No	No	0	4	6
85	R:R:V83	R:R:Y87	3.79	Yes	Yes	0	6	5
86	R:R:F107	R:R:V83	5.24	Yes	Yes	0	6	6
87	R:R:D85	R:R:W93	5.58	No	Yes	0	4	9
88	R:R:Y86	R:R:Y87	11.91	Yes	Yes	1	5	5
89	R:R:W93	R:R:Y86	2.89	Yes	Yes	1	9	5
90	R:R:F107	R:R:Y86	3.09	Yes	Yes	1	6	5
91	R:R:R89	R:R:V88	10.46	No	No	0	4	3
92	R:R:D92	R:R:R89	3.57	No	No	8	3	4
93	R:R:K94	R:R:R89	12.38	No	No	8	3	4
94	R:R:R90	R:R:S91	7.91	No	No	1	3	4
95	R:R:A174	R:R:R90	4.15	No	No	0	3	3
96	R:R:D92	R:R:K94	9.68	No	No	8	3	3
97	R:R:F95	R:R:W93	7.02	No	Yes	1	7	9
98	R:R:P99	R:R:W93	4.05	Yes	Yes	1	5	9
99	R:R:C100	R:R:W93	6.53	No	Yes	1	9	9
100	R:R:V103	R:R:W93	3.68	No	Yes	0	5	9
101	R:R:C177	R:R:W93	5.22	No	Yes	1	9	9
102	R:R:F95	R:R:P99	7.22	No	Yes	1	7	5
103	R:R:G96	R:R:P99	4.06	No	Yes	0	8	5
104	R:R:D97	R:R:K166	8.3	No	No	0	3	5
105	R:R:D97	R:R:L168	6.79	No	No	0	3	4
106	R:R:I98	R:R:P99	3.39	No	Yes	0	1	5
107	R:R:C100	R:R:L168	3.17	No	No	0	9	4
108	R:R:C100	R:R:C177	7.28	No	No	1	9	9
109	R:R:K166	R:R:R101	3.71	No	No	0	5	7
110	R:R:L167	R:R:R101	3.64	No	No	0	4	7
111	R:R:F107	R:R:V103	3.93	Yes	No	0	6	5
112	R:R:L104	R:R:L167	4.15	Yes	No	0	5	4
113	R:R:C177	R:R:L104	4.76	No	Yes	0	9	5
114	R:R:L104	R:R:S179	4.5	Yes	No	0	5	5
115	R:R:F105	R:R:M109	4.98	No	Yes	5	5	5
116	R:R:F105	R:R:T159	5.19	No	No	5	5	6
117	R:R:F105	R:R:L163	9.74	No	No	0	5	4
118	R:R:M106	R:R:N110	4.21	No	Yes	5	5	8
119	R:R:F107	R:R:Y284	5.16	Yes	Yes	1	6	7
120	R:R:M109	R:R:N110	5.61	Yes	Yes	5	5	8
121	R:R:M109	R:R:T155	3.01	Yes	No	0	5	7
122	R:R:M109	R:R:V156	3.04	Yes	No	0	5	4
123	R:R:M109	R:R:T159	3.01	Yes	No	5	5	6
124	R:R:E196	R:R:R111	8.14	Yes	No	0	6	7
125	R:R:R111	R:R:T283	5.17	No	Yes	0	7	8
126	R:R:Q112	R:R:T155	4.25	Yes	No	0	7	7
127	R:R:L158	R:R:Q112	3.99	No	Yes	0	4	7
128	R:R:M192	R:R:Q112	4.08	No	Yes	0	5	7
129	R:R:E196	R:R:Q112	6.37	Yes	Yes	0	6	7
130	R:R:E196	R:R:I115	6.83	Yes	Yes	0	6	8
131	R:R:I115	R:R:P200	3.39	Yes	No	0	8	9
132	R:R:F244	R:R:I115	11.3	Yes	Yes	0	9	8
133	R:R:I116	R:R:L151	4.28	No	No	0	5	7
134	R:R:F117	R:R:W152	7.02	No	No	0	7	9
135	R:R:L118	R:R:Y294	7.03	No	Yes	0	8	9
136	R:R:P200	R:R:T119	3.5	No	No	0	9	7
137	R:R:I203	R:R:T119	4.56	No	No	0	6	7
138	R:R:I204	R:R:T119	3.04	Yes	No	0	8	7
139	R:R:R125	R:R:V121	7.85	No	No	0	9	8
140	R:R:D124	R:R:R128	10.72	No	No	0	8	8
141	R:R:R125	R:R:Y294	5.14	No	Yes	0	9	9
142	R:R:F127	R:R:Y126	5.16	Yes	Yes	2	5	8
143	R:R:V130	R:R:Y126	12.62	No	Yes	2	7	8
144	R:R:H131	R:R:Y126	5.44	No	Yes	2	6	8
145	R:R:F206	R:R:Y126	6.19	No	Yes	2	3	8
146	R:R:C207	R:R:Y126	9.41	No	Yes	0	6	8
147	R:R:R210	R:R:Y126	8.23	No	Yes	2	4	8
148	R:R:I211	R:R:Y126	3.63	No	Yes	0	8	8
149	R:R:F127	R:R:H134	10.18	Yes	No	2	5	5
150	R:R:F127	R:R:L136	7.31	Yes	No	2	5	4
151	R:R:N137	R:R:R128	7.23	No	No	0	4	8
152	R:R:I211	R:R:V129	6.14	No	No	0	8	8
153	R:R:L215	R:R:V129	4.47	Yes	No	0	8	8
154	R:R:H131	R:R:V130	13.84	No	No	2	6	7
155	R:R:H133	R:R:P132	3.05	No	No	0	5	8
156	R:R:H134	R:R:L136	3.86	No	No	2	5	4
157	R:R:I139	R:R:L136	2.85	No	No	0	7	4
158	R:R:S140	R:R:T143	4.8	No	No	0	6	3
159	R:R:I146	R:R:W142	7.05	No	No	0	3	4
160	R:R:I147	R:R:L151	2.85	No	No	0	4	7
161	R:R:I154	R:R:L150	2.85	No	No	0	4	3
162	R:R:G157	R:R:V160	3.68	No	No	0	4	4
163	R:R:L163	R:R:V160	2.98	No	No	0	4	4
164	R:R:H161	R:R:L162	6.43	No	No	0	8	3
165	R:R:H161	R:R:W188	14.81	No	No	0	8	4
166	R:R:H189	R:R:L162	3.86	No	No	0	5	3
167	R:R:K164	R:R:K165	2.87	No	No	0	4	4
168	R:R:L168	R:R:N175	10.98	No	No	0	4	3
169	R:R:G172	R:R:N171	3.39	No	No	0	3	2
170	R:R:A174	R:R:N171	4.69	No	No	0	3	2
171	R:R:I178	R:R:V176	3.07	No	No	0	3	1
172	R:R:F180	R:R:S179	3.96	Yes	No	4	4	5
173	R:R:H189	R:R:S179	11.16	No	No	4	5	5
174	R:R:F180	R:R:H189	11.31	Yes	No	4	4	5
175	R:R:F180	R:R:F193	5.36	Yes	Yes	4	4	5
176	R:R:F180	R:R:R251	5.34	Yes	Yes	4	4	6
177	R:R:F180	R:R:F276	12.86	Yes	No	4	4	4
178	R:R:C183	R:R:S181	3.44	Yes	No	6	1	5
179	R:R:I182	R:R:L258	8.56	No	No	9	2	3
180	R:R:I182	R:R:Y269	6.04	No	Yes	9	2	4
181	R:R:C183	R:R:R187	8.36	Yes	No	0	1	1
182	R:R:H184	R:R:L258	14.14	No	No	0	3	3
183	R:R:R187	R:R:T185	10.35	No	No	0	1	4
184	R:R:F186	R:R:F255	6.43	No	No	0	3	5
185	R:R:M192	R:R:W188	5.82	No	No	0	5	4
186	R:R:E190	R:R:R251	19.77	No	Yes	0	4	6
187	R:R:E190	R:R:F255	9.33	No	No	0	4	5
188	R:R:E196	R:R:F193	4.66	Yes	Yes	0	6	5
189	R:R:F193	R:R:S247	3.96	Yes	No	0	5	6
190	R:R:F193	R:R:R251	6.41	Yes	Yes	4	5	6
191	R:R:F193	R:R:F276	4.29	Yes	No	4	5	4
192	R:R:L194	R:R:V248	2.98	No	No	0	4	8
193	R:R:F197	R:R:F198	6.43	Yes	No	0	8	4
194	R:R:F197	R:R:L201	3.65	Yes	Yes	10	8	6
195	R:R:F197	R:R:F240	3.22	Yes	Yes	10	8	9
196	R:R:F197	R:R:L245	6.09	Yes	No	0	8	5
197	R:R:F197	R:R:V248	9.18	Yes	No	0	8	8
198	R:R:L199	R:R:P200	3.28	No	No	0	5	9
199	R:R:I203	R:R:L199	4.28	No	No	0	6	5
200	R:R:L201	R:R:L205	5.54	Yes	No	0	6	4
201	R:R:F240	R:R:L201	3.65	Yes	Yes	10	9	6
202	R:R:L201	R:R:V241	2.98	Yes	No	0	6	4
203	R:R:F240	R:R:I204	3.77	Yes	Yes	0	9	8
204	R:R:F206	R:R:R210	8.55	No	No	2	3	4
205	R:R:R210	R:R:W213	5	No	No	0	4	4
206	R:R:I211	R:R:I233	2.94	No	No	0	8	7
207	R:R:I212	R:R:I230	7.36	No	No	0	5	5
208	R:R:I212	R:R:M234	2.92	No	No	0	5	5
209	R:R:Q217	R:R:W213	9.86	No	No	0	5	4
210	R:R:L215	R:R:M220	4.24	Yes	No	0	8	3
211	R:R:I226	R:R:L215	2.85	No	Yes	0	7	8
212	R:R:I230	R:R:L215	2.85	No	Yes	0	5	8
213	R:R:D221	R:R:R216	9.53	No	No	0	3	4
214	R:R:M220	R:R:R218	8.69	No	No	0	3	6
215	R:R:Q219	R:R:R222	11.68	No	No	0	4	4
216	R:R:H223	R:R:K225	6.55	No	No	0	3	5
217	R:R:K225	R:R:P299	5.02	No	No	0	5	5
218	R:R:F232	R:R:R228	6.41	Yes	No	0	7	7
219	R:R:P299	R:R:R228	10.09	No	No	0	5	7
220	R:R:F232	R:R:V235	5.24	Yes	No	0	7	5
221	R:R:F232	R:R:S297	14.53	Yes	No	0	7	6
222	R:R:V236	R:R:Y294	8.83	No	Yes	0	7	9
223	R:R:F240	R:R:F244	6.43	Yes	Yes	0	9	9
224	R:R:C243	R:R:N286	9.45	No	No	0	8	9
225	R:R:F244	R:R:T283	3.89	Yes	Yes	0	9	8
226	R:R:F244	R:R:N286	7.25	Yes	No	0	9	9
227	R:R:L245	R:R:P246	3.28	No	No	0	5	9
228	R:R:L245	R:R:V249	2.98	No	No	0	5	5
229	R:R:P246	R:R:T279	5.25	No	No	0	9	6
230	R:R:I252	R:R:V248	3.07	No	No	0	6	8
231	R:R:T279	R:R:V250	3.17	No	No	0	6	4
232	R:R:I254	R:R:R251	6.26	No	Yes	0	5	6
233	R:R:F276	R:R:R251	12.83	No	Yes	4	4	6
234	R:R:H253	R:R:W256	3.17	No	No	0	5	4
235	R:R:H253	R:R:L257	3.86	No	No	0	5	2
236	R:R:I254	R:R:V272	4.61	No	No	0	5	4
237	R:R:T260	R:R:W256	4.85	No	No	0	1	4
238	R:R:L257	R:R:T260	2.95	No	No	0	2	1
239	R:R:L258	R:R:Y269	11.72	No	Yes	9	3	4
240	R:R:G262	R:R:S261	3.71	No	No	0	3	4
241	R:R:S261	R:R:Y269	7.63	No	Yes	0	4	4
242	R:R:Q264	R:R:T263	4.25	No	No	0	1	3
243	R:R:E267	R:R:N265	6.57	No	No	0	1	4
244	R:R:N265	R:R:V268	7.39	No	No	0	4	1
245	R:R:V268	R:R:Y269	8.83	No	Yes	0	1	4
246	R:R:L274	R:R:S271	3	No	No	0	3	2
247	R:R:D273	R:R:F277	3.58	No	No	0	4	5
248	R:R:L280	R:R:T283	7.37	No	Yes	1	5	8
249	R:R:L280	R:R:Y284	3.52	No	Yes	1	5	7
250	R:R:F282	R:R:S281	3.96	No	No	0	7	5
251	R:R:F282	R:R:M285	7.46	No	No	0	7	5
252	R:R:T283	R:R:Y284	7.49	Yes	Yes	1	8	7
253	R:R:L289	R:R:M285	5.65	No	No	0	7	5
254	R:R:D290	R:R:P291	4.83	Yes	No	0	9	9
255	R:R:D290	R:R:Y294	8.05	Yes	Yes	0	9	9
256	R:R:F296	R:R:V292	5.24	No	No	0	7	6
257	R:R:Y294	R:R:Y295	2.98	Yes	Yes	3	9	5
258	R:R:S298	R:R:S300	6.52	No	No	0	8	6
259	R:R:F301	R:R:P302	7.22	No	No	0	8	8
260	R:R:L289	R:R:M288	2.83	No	No	0	7	6
261	R:R:A191	R:R:F186	2.77	No	No	0	2	3
262	R:R:H184	R:R:T263	2.74	No	No	0	3	3
263	R:R:H223	R:R:I226	2.65	No	No	0	3	7
264	R:R:R63	R:R:S300	2.64	No	No	0	7	6
265	R:R:F65	R:R:S148	2.64	No	No	0	6	6
266	R:R:R22	R:R:V176	2.62	Yes	No	0	5	1
267	R:R:F127	R:R:V123	2.62	Yes	No	0	5	6
268	R:R:A72	R:R:W152	2.59	No	No	0	8	9
269	R:R:S214	R:R:W213	2.47	No	No	0	5	4
270	R:R:F40	R:R:L36	2.44	No	No	0	5	4
271	R:R:F296	R:R:L47	2.44	No	No	0	7	5
272	R:R:E190	R:R:R187	2.33	No	No	0	4	1
273	R:R:G113	R:R:T155	1.82	No	No	0	6	7
274	R:R:G172	R:R:T173	1.82	No	No	0	3	5
275	R:R:P299	R:R:S298	1.78	No	No	0	5	8
276	R:R:G41	R:R:I77	1.76	No	Yes	0	8	5
277	R:R:G113	R:R:I116	1.76	No	No	0	6	5
278	R:R:G41	R:R:M288	1.75	No	No	0	8	6
279	R:R:G44	R:R:L43	1.71	No	No	0	7	4
280	R:R:G46	R:R:L49	1.71	No	No	0	1	7
281	R:R:G202	R:R:L201	1.71	No	Yes	0	3	6
282	R:R:C243	R:R:V239	1.71	No	No	0	8	7
283	R:R:G44	R:R:N45	1.7	No	Yes	0	7	9
284	R:R:A275	R:R:V250	1.7	No	No	0	5	4
285	R:R:M84	R:R:P31	1.68	No	No	0	7	6
286	R:R:A108	R:R:T159	1.68	No	No	0	5	6
287	R:R:G172	R:R:Q170	1.64	No	No	0	3	2
288	R:R:C243	R:R:I242	1.64	No	No	0	8	5
289	R:R:A122	R:R:I204	1.62	No	Yes	0	9	8
290	R:R:A237	R:R:I204	1.62	No	Yes	0	7	8
291	R:R:V235	R:R:V293	1.6	No	No	0	5	7
292	R:R:V236	R:R:V293	1.6	No	No	0	7	7
293	R:R:V292	R:R:V293	1.6	No	No	0	6	7
294	R:R:A275	R:R:L274	1.58	No	No	0	5	3
295	R:R:I115	R:R:S114	1.55	Yes	No	0	8	9
296	R:R:I233	R:R:S208	1.55	No	No	0	7	8
297	R:R:I278	R:R:V29	1.54	No	No	0	5	4
298	R:R:I182	R:R:V272	1.54	No	No	0	2	4
299	R:R:H131	R:R:P132	1.53	No	No	0	6	8
300	R:R:K28	R:R:V29	1.52	No	No	0	3	4
301	R:R:I139	R:R:T143	1.52	No	No	0	7	3
302	R:R:I147	R:R:T143	1.52	No	No	0	4	3
303	R:R:F38	R:R:G35	1.51	No	No	0	6	5
304	R:R:F40	R:R:G41	1.51	No	No	0	5	8
305	R:R:L56	R:R:S58	1.5	No	No	0	6	6
306	R:R:D85	R:R:V88	1.46	No	No	0	4	3
307	R:R:I98	R:R:L102	1.43	No	No	0	1	4
308	R:R:I154	R:R:L151	1.43	No	No	0	4	7
309	R:R:I154	R:R:L158	1.43	No	No	0	4	4
310	R:R:I64	R:R:N141	1.42	No	No	0	6	3
311	R:R:G153	R:R:W152	1.41	No	No	0	4	9
312	R:R:D24	R:R:K28	1.38	No	No	0	4	3
313	R:R:L195	R:R:L199	1.38	No	No	0	5	5
314	R:R:D221	R:R:K227	1.38	No	No	0	3	5
315	R:R:H259	R:R:T260	1.37	No	No	0	2	1
316	R:R:A48	R:R:Y295	1.33	No	Yes	0	8	5
317	R:R:R63	R:R:S58	1.32	No	No	0	7	6
318	R:R:F232	R:R:T231	1.3	Yes	No	0	7	6
319	R:R:H134	R:R:N137	1.28	No	No	0	5	4
320	R:R:S140	R:R:W142	1.24	No	No	0	6	4
321	R:R:H55	R:R:W50	1.06	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	17.554	5	1	0
2	R:R:F21	7.0625	4	7	3
3	R:R:R22	5.27571	7	1	5
4	R:R:I26	5.715	4	1	4
5	R:R:N45	6.855	4	0	9
6	R:R:F67	6.166	5	3	6
7	R:R:I77	4.416	5	0	5
8	R:R:V83	4.4925	4	0	6
9	R:R:Y86	7.022	5	1	5
10	R:R:Y87	7.235	4	1	5
11	R:R:W93	4.99571	7	1	9
12	R:R:P99	4.68	4	1	5
13	R:R:L104	4.9575	4	0	5
14	R:R:F107	12.518	5	1	6
15	R:R:M109	3.93	5	5	5
16	R:R:N110	5.2025	4	5	8
17	R:R:Q112	4.6725	4	0	7
18	R:R:I115	5.7675	4	0	8
19	R:R:Y126	7.24	7	2	8
20	R:R:F127	6.3175	4	2	5
21	R:R:F180	7.766	5	4	4
22	R:R:C183	6.345	4	6	1
23	R:R:F193	4.936	5	4	5
24	R:R:E196	6.5	4	0	6
25	R:R:F197	5.714	5	10	8
26	R:R:L201	3.506	5	10	6
27	R:R:I204	2.5125	4	0	8
28	R:R:L215	3.6025	4	0	8
29	R:R:F232	6.87	4	0	7
30	R:R:F240	4.2675	4	10	9
31	R:R:F244	7.2175	4	0	9
32	R:R:R251	10.122	5	4	6
33	R:R:Y269	8.555	4	9	4
34	R:R:T283	5.98	4	1	8
35	R:R:Y284	6.23667	6	1	7
36	R:R:D290	6.5925	4	0	9
37	R:R:Y294	5.925	6	3	9
38	R:R:Y295	4.175	6	3	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L104	35.3677	6.42	Yes	Yes	0	0	5
2	R:R:L104	R:R:S179	26.3245	4.5	Yes	No	0	5	5
3	R:R:F180	R:R:S179	23.0875	3.96	Yes	No	4	4	5
4	R:R:F180	R:R:R251	21.2491	5.34	Yes	Yes	4	4	6
5	R:R:E190	R:R:R251	28.2884	19.77	No	Yes	0	4	6
6	R:R:E190	R:R:R187	17.0301	2.33	No	No	0	4	1
7	R:R:C183	R:R:R187	11.264	8.36	Yes	No	0	1	1
8	L:L:?1	R:R:R111	47.9676	9.01	Yes	No	0	0	7
9	R:R:E196	R:R:R111	55.789	8.14	Yes	No	0	6	7
10	R:R:E196	R:R:F193	52.2265	4.66	Yes	Yes	0	6	5
11	R:R:F193	R:R:R251	44.9874	6.41	Yes	Yes	4	5	6
12	L:L:?1	R:R:Y86	45.2329	14.13	Yes	Yes	1	0	5
13	R:R:R22	R:R:Y86	31.7253	3.09	Yes	Yes	1	5	5
14	R:R:F277	R:R:R22	14.1984	5.34	No	Yes	1	5	5
15	R:R:D273	R:R:F277	15.129	3.58	No	No	0	4	5
16	R:R:D273	R:R:F21	12.1717	5.97	No	Yes	0	4	3
17	R:R:R22	R:R:R90	14.9292	3.2	Yes	No	1	5	3
18	R:R:R111	R:R:T283	27.4549	5.17	No	Yes	0	7	8
19	R:R:F244	R:R:T283	58.5579	3.89	Yes	Yes	0	9	8
20	R:R:F240	R:R:F244	60.2192	6.43	Yes	Yes	0	9	9
21	R:R:F197	R:R:F240	42.6239	3.22	Yes	Yes	10	8	9
22	R:R:F197	R:R:L245	32.1249	6.09	Yes	No	0	8	5
23	R:R:L245	R:R:P246	27.6718	3.28	No	No	0	5	9
24	R:R:P246	R:R:T279	25.4282	5.25	No	No	0	9	6
25	R:R:T279	R:R:V250	23.1731	3.17	No	No	0	6	4
26	R:R:A275	R:R:V250	20.9066	1.7	No	No	0	5	4
27	R:R:A275	R:R:L274	18.6287	1.58	No	No	0	5	3
28	R:R:F25	R:R:L274	14.0386	3.65	No	No	0	5	3
29	R:R:F25	R:R:V29	11.7264	7.87	No	No	0	5	4
30	L:L:?1	R:R:Y284	60.2934	13.04	Yes	Yes	1	0	7
31	R:R:T283	R:R:Y284	67.4355	7.49	Yes	Yes	1	8	7
32	R:R:F107	R:R:V83	15.0263	5.24	Yes	Yes	0	6	6
33	R:R:L34	R:R:V83	11.3782	5.96	No	Yes	0	8	6
34	R:R:L80	R:R:Y284	71.9342	3.52	No	Yes	0	8	7
35	R:R:I77	R:R:L80	100	2.85	Yes	No	0	5	8
36	R:R:G41	R:R:I77	23.4586	1.76	No	Yes	0	8	5
37	R:R:G41	R:R:M288	16.5392	1.75	No	No	0	8	6
38	R:R:I77	R:R:L42	10.6474	2.85	Yes	No	0	5	6
39	R:R:W93	R:R:Y86	39.992	2.89	Yes	Yes	1	9	5
40	R:R:D85	R:R:W93	14.0043	5.58	No	Yes	0	4	9
41	R:R:I77	R:R:N45	59.7454	7.08	Yes	Yes	0	5	9
42	R:R:G44	R:R:N45	49.0066	1.7	No	Yes	0	7	9
43	R:R:F296	R:R:G44	43.0578	3.01	No	No	0	7	7
44	R:R:L76	R:R:Y284	52.9459	4.69	No	Yes	0	6	7
45	R:R:L76	R:R:S287	44.1025	6.01	No	No	0	6	8
46	R:R:D73	R:R:S287	43.2918	5.89	No	No	0	9	8
47	R:R:F296	R:R:L47	18.4688	2.44	No	No	0	7	5
48	R:R:I51	R:R:L47	16.2594	2.85	No	No	0	7	5
49	R:R:F74	R:R:I77	39.05	7.54	No	Yes	0	7	5
50	R:R:F74	R:R:L49	35.8187	7.31	No	No	0	7	7
51	R:R:F67	R:R:L49	33.2724	3.65	Yes	No	0	6	7
52	R:R:F301	R:R:I51	13.9358	5.02	No	No	0	8	7
53	R:R:F67	R:R:W59	15.7056	4.01	Yes	No	3	6	6
54	R:R:D290	R:R:D73	45.5469	3.99	Yes	No	0	9	9
55	R:R:D290	R:R:L69	12.0176	9.5	Yes	No	0	9	9
56	R:R:D290	R:R:Y294	38.2051	8.05	Yes	Yes	0	9	9
57	R:R:Y294	R:R:Y295	12.0918	2.98	Yes	Yes	3	9	5
58	R:R:I64	R:R:W59	19.7077	3.52	No	No	0	6	6
59	R:R:E196	R:R:Q112	42.5953	6.37	Yes	Yes	0	6	7
60	R:R:L158	R:R:Q112	34.1003	3.99	No	Yes	0	4	7
61	R:R:I154	R:R:L158	32.7986	1.43	No	No	0	4	4
62	R:R:I154	R:R:L151	30.6406	1.43	No	No	0	4	7
63	R:R:I147	R:R:L151	34.3629	2.85	No	No	0	4	7
64	R:R:I147	R:R:T143	33.6321	1.52	No	No	0	4	3
65	R:R:I139	R:R:T143	32.536	1.52	No	No	0	7	3
66	R:R:I139	R:R:S61	15.2546	4.64	No	No	0	7	7
67	R:R:A144	R:R:I64	16.4193	6.5	No	No	0	8	6
68	R:R:A144	R:R:S61	15.5287	3.42	No	No	0	8	7
69	R:R:I139	R:R:L136	37.7369	2.85	No	No	0	7	4
70	R:R:F67	R:R:N68	17.7381	4.83	Yes	No	0	6	9
71	R:R:L76	R:R:N110	21.4261	4.12	No	Yes	0	6	8
72	R:R:D85	R:R:V88	11.2526	1.46	No	No	0	4	3
73	R:R:A174	R:R:R90	12.4971	4.15	No	No	0	3	3
74	R:R:P99	R:R:W93	18.2861	4.05	Yes	Yes	1	5	9
75	R:R:C100	R:R:W93	17.5953	6.53	No	Yes	1	9	9
76	R:R:C177	R:R:L104	10.7616	4.76	No	Yes	0	9	5
77	R:R:F107	R:R:V103	16.4021	3.93	Yes	No	0	6	5
78	R:R:C100	R:R:L168	17.8694	3.17	No	No	0	9	4
79	R:R:M109	R:R:N110	17.544	5.61	Yes	Yes	5	5	8
80	R:R:E196	R:R:I115	24.6118	6.83	Yes	Yes	0	6	8
81	R:R:I115	R:R:P200	11.4695	3.39	Yes	No	0	8	9
82	R:R:F127	R:R:L136	29.5387	7.31	Yes	No	2	5	4
83	R:R:F127	R:R:Y126	28.1685	5.16	Yes	Yes	2	5	8
84	R:R:I211	R:R:Y126	15.4887	3.63	No	Yes	0	8	8
85	R:R:I211	R:R:V129	11.9947	6.14	No	No	0	8	8
86	R:R:L215	R:R:V129	10.8644	4.47	Yes	No	0	8	8
87	R:R:A174	R:R:N171	10.0194	4.69	No	No	0	3	2
88	R:R:I254	R:R:R251	37.2517	6.26	No	Yes	0	5	6
89	R:R:I254	R:R:V272	34.4542	4.61	No	No	0	5	4
90	R:R:I182	R:R:V272	31.6454	1.54	No	No	0	2	4
91	R:R:I182	R:R:L258	11.5266	8.56	No	No	9	2	3
92	R:R:I182	R:R:Y269	17.2928	6.04	No	Yes	9	2	4
93	R:R:V236	R:R:Y294	23.1046	8.83	No	Yes	0	7	9
94	R:R:V236	R:R:V293	21.1235	1.6	No	No	0	7	7
95	R:R:V235	R:R:V293	42.4754	1.6	No	No	0	5	7
96	R:R:F232	R:R:V235	39.815	5.24	Yes	No	0	7	5
97	R:R:F232	R:R:R228	31.457	6.41	Yes	No	0	7	7
98	R:R:P299	R:R:R228	28.728	10.09	No	No	0	5	7
99	R:R:K225	R:R:P299	13.2222	5.02	No	No	0	5	5
100	R:R:H223	R:R:K225	10.5389	6.55	No	No	0	3	5
101	R:R:F296	R:R:V292	28.9164	5.24	No	No	0	7	6
102	R:R:V292	R:R:V293	27.5462	1.6	No	No	0	6	7
103	R:R:P299	R:R:S298	15.4373	1.78	No	No	0	5	8
104	R:R:S298	R:R:S300	12.2402	6.52	No	No	0	8	6
105	R:R:F107	R:R:Y284	33.0897	5.16	Yes	Yes	1	6	7
106	R:R:F107	R:R:Y86	23.0532	3.09	Yes	Yes	1	6	5
107	R:R:V83	R:R:Y87	21.0836	3.79	Yes	Yes	0	6	5
108	R:R:L80	R:R:V83	34.4771	2.98	No	Yes	0	8	6
109	R:R:V103	R:R:W93	14.7979	3.68	No	Yes	0	5	9
110	R:R:M109	R:R:T155	11.9719	3.01	Yes	No	0	5	7
111	R:R:F244	R:R:I115	22.3624	11.3	Yes	Yes	0	9	8
112	R:R:R22	R:R:Y87	10.596	7.2	Yes	Yes	1	5	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y86	14.13	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L104	6.42	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F107	45.17	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:R111	9.01	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y284	13.04	1	Yes	Yes	0	7	0	1
R:R:R22	R:R:Y86	3.09	1	Yes	Yes	5	5	2	1
R:R:R22	R:R:Y87	7.2	1	Yes	Yes	5	5	2	2
R:R:L76	R:R:Y284	4.69	0	No	Yes	6	7	2	1
R:R:L80	R:R:V83	2.98	0	No	Yes	8	6	2	2
R:R:L80	R:R:Y284	3.52	0	No	Yes	8	7	2	1
R:R:V83	R:R:Y87	3.79	0	Yes	Yes	6	5	2	2
R:R:F107	R:R:V83	5.24	1	Yes	Yes	6	6	1	2
R:R:Y86	R:R:Y87	11.91	1	Yes	Yes	5	5	1	2
R:R:W93	R:R:Y86	2.89	1	Yes	Yes	9	5	2	1
R:R:F107	R:R:Y86	3.09	1	Yes	Yes	6	5	1	1
R:R:V103	R:R:W93	3.68	0	No	Yes	5	9	2	2
R:R:C177	R:R:W93	5.22	1	No	Yes	9	9	2	2
R:R:F107	R:R:V103	3.93	1	Yes	No	6	5	1	2
R:R:L104	R:R:L167	4.15	0	Yes	No	5	4	1	2
R:R:C177	R:R:L104	4.76	1	No	Yes	9	5	2	1
R:R:L104	R:R:S179	4.5	0	Yes	No	5	5	1	2
R:R:F107	R:R:Y284	5.16	1	Yes	Yes	6	7	1	1
R:R:E196	R:R:R111	8.14	0	Yes	No	6	7	2	1
R:R:R111	R:R:T283	5.17	0	No	Yes	7	8	1	2
R:R:L280	R:R:T283	7.37	1	No	Yes	5	8	2	2
R:R:L280	R:R:Y284	3.52	1	No	Yes	5	7	2	1
R:R:T283	R:R:Y284	7.49	1	Yes	Yes	8	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9JID_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	275
Number of Links	321
Number of Hubs	38
Number of Links mediated by Hubs	144
Number of Communities	10
Number of Nodes involved in Communities	59
Number of Links involved in Communities	75

Path Summary
Number Of Nodes in MetaPath	113
Number Of Links MetaPath	112
Number of Shortest Paths	57719
Length Of Smallest Path	3
Average Path Length	12.8178
Length of Longest Path	32
Minimum Path Strength	1.41
Average Path Strength	5.28539
Maximum Path Strength	27.09
Minimum Path Correlation	0.7
Average Path Correlation	0.922918
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	50.2218
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.8392
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • multicellular organismal process • system process • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • nicotinic acid receptor activity • negative regulation of catabolic process • lipid catabolic process • catabolic process • negative regulation of metabolic process • regulation of catabolic process • regulation of lipid catabolic process • negative regulation of lipid metabolic process • negative regulation of lipid catabolic process
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NIO
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	NIO
Name	Niacin
Synonyms	β-pyridinecarboxylic acid
Identifier
Formula	C6 H5 N O2
Molecular Weight	123.109
SMILES
PubChem	938
Formal Charge	0
Total Atoms	14
Total Chiral Atoms	0
Total Bonds	14
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49019
Sequence	>9JID_nogp_Chain_R K K N C C V F R D D F I A K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F V M D Y Y V R R S D W K F G D I P C R L V L F M F A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N W T A A I I S C L L W G I T V G L T V H L L K K K L L I Q N G T A N V C I S F S I C H T F R W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I H I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F P N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IHJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.07	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-		3.07	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHK	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-	-	3.21	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	9JKS	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 44250176	-	Gi1/β1/γ2	3.31	2025-10-29	To be published
	9JKS (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 44250176	-		3.31	2025-10-29	To be published
	9JKT	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	(2R)-2-hydroxy-3-phenylpropanoic acid	-	Gi1/β1/γ2	3.05	2025-10-29	To be published
	9JKT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	(2R)-2-hydroxy-3-phenylpropanoic acid	-		3.05	2025-10-29	To be published
	9JKV	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 2736690	-	Gi1/β1/γ2	3.26	2025-10-29	To be published
	9JKV (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 2736690	-		3.26	2025-10-29	To be published
	9JKX	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.18	2025-10-29	To be published
	9JKX (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-		3.18	2025-10-29	To be published
	8JEF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 11367166	-	Gi1/β1/γ2	2.96	2024-12-18	doi.org/10.1016/j.celrep.2024.114895
	8JEF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 11367166	-		2.96	2024-12-18	doi.org/10.1016/j.celrep.2024.114895
	9KT6	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.01	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT6 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-		3.01	2025-12-10	10.1021/acs.jmedchem.4c02567
	9JIC	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	-	-	Gi1/β1/γ2	3.4	2025-12-17	10.1016/j.celrep.2024.114895
	9JIC (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	-	-		3.4	2025-12-17	10.1016/j.celrep.2024.114895
	9JID	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.78	2025-12-17	10.1016/j.celrep.2024.114895
	9JID (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Niacin	-		2.78	2025-12-17	10.1016/j.celrep.2024.114895

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