psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:V83	13.06	Yes	No	1	0	6
2	L:L:?1	R:R:Y86	9.25	Yes	No	0	0	5
3	L:L:?1	R:R:L104	3.64	Yes	No	1	0	5
4	L:L:?1	R:R:F107	10.68	Yes	Yes	1	0	6
5	L:L:?1	R:R:S179	5.27	Yes	No	1	0	5
6	L:L:?1	R:R:F180	7.47	Yes	Yes	1	0	4
7	L:L:?1	R:R:F277	12.81	Yes	No	0	0	5
8	L:L:?1	R:R:L280	3.64	Yes	No	0	0	5
9	L:L:?1	R:R:Y284	11.31	Yes	Yes	1	0	7
10	R:R:C18	R:R:V20	3.42	No	Yes	0	8	2
11	R:R:C18	R:R:C183	7.28	No	No	0	8	1
12	R:R:C19	R:R:F21	4.19	No	No	0	3	3
13	R:R:C19	R:R:C266	7.28	No	No	0	3	6
14	R:R:I169	R:R:V20	4.61	No	Yes	0	1	2
15	R:R:I178	R:R:V20	12.29	No	Yes	6	3	2
16	R:R:S181	R:R:V20	8.08	No	Yes	6	5	2
17	R:R:F21	R:R:R270	7.48	No	Yes	0	3	2
18	R:R:R22	R:R:R90	10.66	Yes	No	0	5	3
19	R:R:R22	R:R:S91	9.22	Yes	No	0	5	4
20	R:R:N171	R:R:R22	3.62	No	Yes	0	2	5
21	R:R:D23	R:R:F25	3.58	Yes	Yes	7	5	5
22	R:R:D23	R:R:I26	9.8	Yes	No	0	5	4
23	R:R:D23	R:R:L274	6.79	Yes	No	7	5	3
24	R:R:F25	R:R:K28	3.72	Yes	No	0	5	3
25	R:R:F25	R:R:V29	3.93	Yes	No	0	5	4
26	R:R:F25	R:R:L274	6.09	Yes	No	7	5	3
27	R:R:I26	R:R:L30	9.99	No	No	0	4	6
28	R:R:L30	R:R:P31	3.28	No	Yes	0	6	6
29	R:R:P31	R:R:P32	5.84	Yes	No	5	6	4
30	R:R:M84	R:R:P31	3.35	No	Yes	5	7	6
31	R:R:P31	R:R:Y87	20.86	Yes	No	5	6	5
32	R:R:P32	R:R:Y87	4.17	No	No	5	4	5
33	R:R:E37	R:R:Y284	3.37	No	Yes	0	7	7
34	R:R:E37	R:R:M285	4.06	No	Yes	0	7	5
35	R:R:E37	R:R:M288	9.47	No	No	0	7	6
36	R:R:F38	R:R:L42	3.65	Yes	No	0	6	6
37	R:R:F38	R:R:L80	6.09	Yes	No	0	6	8
38	R:R:F38	R:R:P81	5.78	Yes	No	0	6	9
39	R:R:F40	R:R:L43	8.53	No	No	0	5	4
40	R:R:F40	R:R:M288	9.95	No	No	0	5	6
41	R:R:G41	R:R:S287	3.71	No	No	0	8	8
42	R:R:F74	R:R:L42	4.87	No	No	0	7	6
43	R:R:I77	R:R:L42	9.99	No	No	0	5	6
44	R:R:G44	R:R:L43	5.13	No	No	0	7	4
45	R:R:D73	R:R:N45	13.46	No	No	0	9	9
46	R:R:F74	R:R:N45	10.87	No	No	0	7	9
47	R:R:N45	R:R:P291	3.26	No	No	0	9	9
48	R:R:G46	R:R:W50	4.22	No	No	0	1	4
49	R:R:I51	R:R:L47	7.14	No	No	8	7	5
50	R:R:F296	R:R:L47	4.87	No	No	8	7	5
51	R:R:A48	R:R:Y295	5.34	No	Yes	0	8	5
52	R:R:F74	R:R:L49	6.09	No	No	0	7	7
53	R:R:F296	R:R:I51	5.02	No	No	8	7	7
54	R:R:F301	R:R:I51	10.05	No	No	0	8	7
55	R:R:F52	R:R:Y295	10.32	No	Yes	0	7	5
56	R:R:C53	R:R:F54	11.17	No	No	0	2	4
57	R:R:F54	R:R:H55	3.39	No	No	0	4	5
58	R:R:F301	R:R:H55	10.18	No	No	0	8	5
59	R:R:L56	R:R:W59	11.39	No	No	0	6	6
60	R:R:L56	R:R:R63	9.72	No	Yes	0	6	7
61	R:R:I64	R:R:W59	3.52	No	No	0	6	6
62	R:R:F67	R:R:W59	9.02	No	No	0	6	6
63	R:R:I139	R:R:S61	7.74	No	No	0	7	7
64	R:R:A144	R:R:S61	3.42	No	No	0	8	7
65	R:R:I64	R:R:N141	4.25	No	No	0	6	3
66	R:R:A144	R:R:I64	4.87	No	No	0	8	6
67	R:R:F65	R:R:V120	7.87	No	No	0	6	6
68	R:R:L66	R:R:Y294	3.52	No	Yes	0	8	9
69	R:R:L66	R:R:Y295	4.69	No	Yes	0	8	5
70	R:R:F67	R:R:N68	3.62	No	Yes	0	6	9
71	R:R:F67	R:R:V71	7.87	No	No	0	6	5
72	R:R:F117	R:R:N68	10.87	No	Yes	2	7	9
73	R:R:N68	R:R:S148	8.94	Yes	No	0	9	6
74	R:R:N68	R:R:W152	4.52	Yes	Yes	2	9	9
75	R:R:L69	R:R:Y295	5.86	No	Yes	0	9	5
76	R:R:A70	R:R:Y295	5.34	No	Yes	0	8	5
77	R:R:A72	R:R:W152	3.89	No	Yes	0	8	9
78	R:R:D73	R:R:S287	8.83	No	No	0	9	8
79	R:R:D290	R:R:D73	5.32	Yes	No	0	9	9
80	R:R:L75	R:R:N110	8.24	No	No	0	6	8
81	R:R:L76	R:R:N110	10.98	No	No	0	6	8
82	R:R:L76	R:R:Y284	3.52	No	Yes	0	6	7
83	R:R:C79	R:R:I78	3.27	No	No	9	6	4
84	R:R:I78	R:R:M106	5.83	No	No	9	4	5
85	R:R:C79	R:R:V103	5.12	No	No	0	6	5
86	R:R:C79	R:R:M106	4.86	No	No	9	6	5
87	R:R:F82	R:R:F95	4.29	No	No	0	6	7
88	R:R:F107	R:R:V83	5.24	Yes	No	1	6	6
89	R:R:M84	R:R:Y87	5.99	No	No	5	7	5
90	R:R:W93	R:R:Y86	7.72	Yes	No	0	9	5
91	R:R:D92	R:R:V88	4.38	Yes	No	0	3	3
92	R:R:D92	R:R:R89	5.96	Yes	No	0	3	4
93	R:R:D92	R:R:K94	13.83	Yes	No	0	3	3
94	R:R:F95	R:R:W93	9.02	No	Yes	0	7	9
95	R:R:C100	R:R:W93	19.59	Yes	Yes	4	9	9
96	R:R:N175	R:R:W93	6.78	Yes	Yes	4	3	9
97	R:R:F95	R:R:P99	11.56	No	No	0	7	5
98	R:R:G96	R:R:P99	4.06	No	No	0	8	5
99	R:R:D97	R:R:K164	5.53	No	No	0	3	4
100	R:R:D97	R:R:L168	5.43	No	No	0	3	4
101	R:R:I98	R:R:P99	3.39	No	No	0	1	5
102	R:R:I98	R:R:R101	10.02	No	Yes	2	1	7
103	R:R:I98	R:R:K164	11.63	No	No	2	1	4
104	R:R:C100	R:R:L167	3.17	Yes	No	4	9	4
105	R:R:C100	R:R:N175	6.3	Yes	Yes	4	9	3
106	R:R:C100	R:R:C177	7.28	Yes	No	4	9	9
107	R:R:L102	R:R:R101	4.86	No	Yes	0	4	7
108	R:R:L163	R:R:R101	20.65	No	Yes	2	4	7
109	R:R:K164	R:R:R101	17.33	No	Yes	2	4	7
110	R:R:F107	R:R:V103	3.93	Yes	No	0	6	5
111	R:R:L104	R:R:S179	4.5	No	No	1	5	5
112	R:R:F105	R:R:M109	4.98	Yes	Yes	2	5	5
113	R:R:F105	R:R:T159	3.89	Yes	No	2	5	6
114	R:R:F105	R:R:V160	5.24	Yes	No	2	5	4
115	R:R:F105	R:R:L163	4.87	Yes	No	2	5	4
116	R:R:M106	R:R:N110	5.61	No	No	0	5	8
117	R:R:F107	R:R:Y284	7.22	Yes	Yes	1	6	7
118	R:R:A108	R:R:T159	3.36	No	No	0	5	6
119	R:R:M109	R:R:W152	3.49	Yes	Yes	2	5	9
120	R:R:M109	R:R:T159	6.02	Yes	No	2	5	6
121	R:R:F180	R:R:R111	4.28	Yes	No	0	4	7
122	R:R:F193	R:R:R111	17.1	Yes	No	0	5	7
123	R:R:R111	R:R:T283	3.88	No	No	0	7	8
124	R:R:Q112	R:R:T155	7.09	Yes	No	0	7	7
125	R:R:L158	R:R:Q112	9.32	No	Yes	0	4	7
126	R:R:F193	R:R:Q112	3.51	Yes	Yes	1	5	7
127	R:R:E196	R:R:Q112	11.47	No	Yes	1	6	7
128	R:R:I115	R:R:P200	3.39	No	No	0	8	9
129	R:R:F244	R:R:I115	6.28	No	No	0	9	8
130	R:R:I116	R:R:L151	5.71	No	No	0	5	7
131	R:R:F117	R:R:W152	7.02	No	Yes	2	7	9
132	R:R:L118	R:R:Y294	8.21	No	Yes	0	8	9
133	R:R:P200	R:R:T119	3.5	No	No	0	9	7
134	R:R:I203	R:R:T119	4.56	No	No	0	6	7
135	R:R:R125	R:R:V121	5.23	No	No	0	9	8
136	R:R:D124	R:R:R128	10.72	No	No	0	8	8
137	R:R:F127	R:R:Y126	5.16	Yes	Yes	3	5	8
138	R:R:V130	R:R:Y126	10.09	No	Yes	3	7	8
139	R:R:H131	R:R:Y126	6.53	No	Yes	3	6	8
140	R:R:F206	R:R:Y126	3.09	No	Yes	3	3	8
141	R:R:C207	R:R:Y126	9.41	No	Yes	0	6	8
142	R:R:R210	R:R:Y126	6.17	No	Yes	3	4	8
143	R:R:I211	R:R:Y126	3.63	No	Yes	0	8	8
144	R:R:F127	R:R:H134	4.53	Yes	No	3	5	5
145	R:R:F127	R:R:L136	8.53	Yes	No	3	5	4
146	R:R:N137	R:R:R128	4.82	No	No	0	4	8
147	R:R:I211	R:R:V129	7.68	No	No	0	8	8
148	R:R:H131	R:R:V130	6.92	No	No	3	6	7
149	R:R:H134	R:R:L136	3.86	No	No	3	5	4
150	R:R:I146	R:R:W142	14.09	No	No	0	3	4
151	R:R:T155	R:R:W152	3.64	No	Yes	0	7	9
152	R:R:L163	R:R:V160	4.47	No	No	2	4	4
153	R:R:H161	R:R:W188	20.1	No	No	0	8	4
154	R:R:H161	R:R:H189	13.14	No	No	0	8	5
155	R:R:K165	R:R:L162	8.46	No	No	0	4	3
156	R:R:L167	R:R:N175	4.12	No	Yes	4	4	3
157	R:R:C177	R:R:L167	4.76	No	No	4	9	4
158	R:R:L168	R:R:N175	19.22	No	Yes	0	4	3
159	R:R:I169	R:R:V176	16.9	No	No	0	1	1
160	R:R:G172	R:R:N171	6.79	No	No	0	3	2
161	R:R:T173	R:R:V176	3.17	No	No	0	5	1
162	R:R:C177	R:R:N175	9.45	No	Yes	4	9	3
163	R:R:I178	R:R:S181	9.29	No	No	6	3	5
164	R:R:F277	R:R:I178	3.77	No	No	0	5	3
165	R:R:F180	R:R:S179	3.96	Yes	No	1	4	5
166	R:R:F180	R:R:H189	16.97	Yes	No	0	4	5
167	R:R:F180	R:R:F276	7.5	Yes	Yes	1	4	4
168	R:R:C183	R:R:S181	5.16	No	No	0	1	5
169	R:R:I182	R:R:I254	13.25	No	No	0	2	5
170	R:R:I182	R:R:Y269	4.84	No	No	0	2	4
171	R:R:D273	R:R:I182	11.2	No	No	0	4	2
172	R:R:H184	R:R:L258	9	No	No	0	3	3
173	R:R:R187	R:R:T185	18.11	No	No	0	1	4
174	R:R:E190	R:R:R187	6.98	Yes	No	0	4	1
175	R:R:E190	R:R:R251	4.65	Yes	Yes	1	4	6
176	R:R:E190	R:R:F255	7	Yes	No	0	4	5
177	R:R:E190	R:R:F276	8.16	Yes	Yes	1	4	4
178	R:R:E196	R:R:F193	12.83	No	Yes	1	6	5
179	R:R:F193	R:R:R251	4.28	Yes	Yes	1	5	6
180	R:R:L194	R:R:V248	4.47	No	No	0	4	8
181	R:R:E196	R:R:L195	6.63	No	No	0	6	5
182	R:R:F197	R:R:F198	6.43	Yes	No	0	8	4
183	R:R:F197	R:R:L201	3.65	Yes	Yes	10	8	6
184	R:R:F197	R:R:F240	3.22	Yes	No	10	8	9
185	R:R:F197	R:R:L245	7.31	Yes	No	0	8	5
186	R:R:F197	R:R:V248	11.8	Yes	No	0	8	8
187	R:R:L199	R:R:P200	6.57	No	No	0	5	9
188	R:R:F240	R:R:L201	3.65	No	Yes	10	9	6
189	R:R:F206	R:R:R210	5.34	No	No	3	3	4
190	R:R:I233	R:R:S208	4.64	No	No	0	7	8
191	R:R:R210	R:R:W213	4	No	No	0	4	4
192	R:R:I212	R:R:I230	7.36	No	No	0	5	5
193	R:R:I212	R:R:I233	4.42	No	No	0	5	7
194	R:R:D221	R:R:R216	4.76	No	No	0	3	4
195	R:R:Q217	R:R:R218	4.67	No	No	0	5	6
196	R:R:M220	R:R:R218	4.96	No	No	0	3	6
197	R:R:K227	R:R:R228	4.95	No	No	0	5	7
198	R:R:R228	R:R:T231	5.17	No	No	0	7	6
199	R:R:F232	R:R:R228	7.48	No	No	0	7	7
200	R:R:F232	R:R:S297	7.93	No	No	0	7	6
201	R:R:I238	R:R:M234	4.37	No	No	0	4	5
202	R:R:V236	R:R:Y294	11.36	No	Yes	0	7	9
203	R:R:F240	R:R:F244	3.22	No	No	0	9	9
204	R:R:C243	R:R:M285	3.24	No	Yes	0	8	5
205	R:R:C243	R:R:N286	7.87	No	No	0	8	9
206	R:R:F244	R:R:N286	12.08	No	No	0	9	9
207	R:R:L245	R:R:P246	3.28	No	No	0	5	9
208	R:R:P246	R:R:T279	3.5	No	No	0	9	6
209	R:R:R251	R:R:S247	7.91	Yes	No	0	6	6
210	R:R:I252	R:R:V248	3.07	No	No	0	6	8
211	R:R:T279	R:R:V250	4.76	No	No	0	6	4
212	R:R:F276	R:R:R251	8.55	Yes	Yes	1	4	6
213	R:R:H253	R:R:L257	10.29	No	Yes	0	5	2
214	R:R:I254	R:R:V272	6.14	No	No	0	5	4
215	R:R:L257	R:R:Y269	8.21	Yes	No	0	2	4
216	R:R:L257	R:R:V272	4.47	Yes	No	0	2	4
217	R:R:E267	R:R:N265	11.83	No	No	0	1	4
218	R:R:C266	R:R:R270	5.57	No	Yes	0	6	2
219	R:R:D273	R:R:R270	3.57	No	Yes	0	4	2
220	R:R:F276	R:R:L280	4.87	Yes	No	0	4	5
221	R:R:L280	R:R:T283	8.84	No	No	0	5	8
222	R:R:F282	R:R:S281	6.61	No	No	0	7	5
223	R:R:F282	R:R:M285	3.73	No	Yes	0	7	5
224	R:R:L289	R:R:M285	7.07	No	Yes	0	7	5
225	R:R:D290	R:R:N286	12.12	Yes	No	0	9	9
226	R:R:D290	R:R:P291	4.83	Yes	No	0	9	9
227	R:R:D290	R:R:Y294	3.45	Yes	Yes	0	9	9
228	R:R:V293	R:R:Y294	5.05	No	Yes	0	7	9
229	R:R:P299	R:R:S298	3.56	No	No	0	5	8
230	R:R:M109	R:R:V156	3.04	Yes	No	0	5	4
231	R:R:I204	R:R:T119	3.04	No	No	0	8	7
232	R:R:I147	R:R:T143	3.04	No	No	0	4	3
233	R:R:F38	R:R:G35	3.01	Yes	No	0	6	5
234	R:R:L257	R:R:S261	3	Yes	No	0	2	4
235	R:R:L201	R:R:V241	2.98	Yes	No	0	6	4
236	R:R:L289	R:R:V239	2.98	No	No	0	7	7
237	R:R:L245	R:R:V249	2.98	No	No	0	5	5
238	R:R:I211	R:R:I233	2.94	No	No	0	8	7
239	R:R:I226	R:R:I230	2.94	Yes	No	11	7	5
240	R:R:I212	R:R:M234	2.92	No	No	0	5	5
241	R:R:D92	R:R:T173	2.89	Yes	No	0	3	5
242	R:R:I278	R:R:L30	2.85	No	No	0	5	6
243	R:R:I39	R:R:L43	2.85	No	No	0	5	4
244	R:R:I146	R:R:L150	2.85	No	No	0	3	3
245	R:R:I147	R:R:L150	2.85	No	No	0	4	3
246	R:R:I147	R:R:L151	2.85	No	No	0	4	7
247	R:R:I154	R:R:L158	2.85	No	No	0	4	4
248	R:R:I226	R:R:L215	2.85	Yes	No	11	7	8
249	R:R:I230	R:R:L215	2.85	No	No	11	5	8
250	R:R:I278	R:R:L274	2.85	No	No	0	5	3
251	R:R:K166	R:R:L162	2.82	No	No	0	5	3
252	R:R:L201	R:R:L205	2.77	Yes	No	0	6	4
253	R:R:M192	R:R:Q112	2.72	No	Yes	0	5	7
254	R:R:R63	R:R:S58	2.64	Yes	No	0	7	6
255	R:R:R63	R:R:S300	2.64	Yes	No	0	7	6
256	R:R:F65	R:R:S148	2.64	No	No	0	6	6
257	R:R:F127	R:R:V123	2.62	Yes	No	0	5	6
258	R:R:V121	R:R:Y294	2.52	No	Yes	0	8	9
259	R:R:V268	R:R:Y269	2.52	No	No	0	1	4
260	L:L:?1	R:R:L34	2.43	Yes	No	0	0	8
261	R:R:D273	R:R:F277	2.39	No	No	0	4	5
262	R:R:D23	R:R:R270	2.38	Yes	Yes	0	5	2
263	R:R:L49	R:R:W50	2.28	No	No	0	7	4
264	R:R:F21	R:R:R22	2.14	No	Yes	0	3	5
265	R:R:F54	R:R:W50	2	No	No	0	4	4
266	R:R:G153	R:R:V156	1.84	No	No	0	4	4
267	R:R:G157	R:R:V156	1.84	No	No	0	4	4
268	R:R:G113	R:R:T155	1.82	No	No	0	6	7
269	R:R:P291	R:R:V292	1.77	No	No	0	9	6
270	R:R:G113	R:R:I116	1.76	No	No	0	6	5
271	R:R:G202	R:R:L201	1.71	No	Yes	0	3	6
272	R:R:A275	R:R:V250	1.7	No	No	0	5	4
273	R:R:K225	R:R:P299	1.67	No	No	0	5	5
274	R:R:C207	R:R:I203	1.64	No	No	0	6	6
275	R:R:C243	R:R:I242	1.64	No	No	0	8	5
276	R:R:S297	R:R:S298	1.63	No	No	0	6	8
277	R:R:S298	R:R:S300	1.63	No	No	0	8	6
278	R:R:A27	R:R:I26	1.62	No	No	0	4	4
279	R:R:S281	R:R:V33	1.62	No	No	0	5	6
280	R:R:A122	R:R:I204	1.62	No	No	0	9	8
281	R:R:S214	R:R:V130	1.62	No	No	0	5	7
282	R:R:A145	R:R:I146	1.62	No	No	0	4	3
283	R:R:A237	R:R:I204	1.62	No	No	0	7	8
284	R:R:S140	R:R:T143	1.6	No	No	0	6	3
285	R:R:V235	R:R:V239	1.6	No	No	0	5	7
286	R:R:V235	R:R:V293	1.6	No	No	0	5	7
287	R:R:S261	R:R:T260	1.6	No	No	0	4	1
288	R:R:K60	R:R:S62	1.53	No	No	0	7	8
289	R:R:H131	R:R:P132	1.53	No	No	0	6	8
290	R:R:D124	R:R:S62	1.47	No	No	0	8	8
291	R:R:A135	R:R:H134	1.46	No	No	0	5	5
292	R:R:I39	R:R:L36	1.43	No	No	0	5	4
293	R:R:Q264	R:R:T263	1.42	No	No	0	1	3
294	R:R:L215	R:R:M220	1.41	No	No	0	8	3
295	R:R:D221	R:R:I226	1.4	No	Yes	0	3	7
296	R:R:A191	R:R:F186	1.39	No	No	0	2	3
297	R:R:H223	R:R:I226	1.33	No	Yes	0	3	7
298	R:R:R63	R:R:S62	1.32	Yes	No	0	7	8
299	R:R:N265	R:R:Q264	1.32	No	No	0	4	1
300	R:R:D24	R:R:F25	1.19	No	Yes	0	4	5
301	R:R:D24	R:R:R90	1.19	No	No	0	4	3
302	R:R:H223	R:R:R222	1.13	No	No	0	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.956	10	1	0
2	R:R:V20	7.1	4	6	2
3	R:R:R22	6.41	4	0	5
4	R:R:D23	5.6375	4	7	5
5	R:R:F25	3.702	5	7	5
6	R:R:P31	8.3325	4	5	6
7	R:R:F38	4.6325	4	0	6
8	R:R:R63	4.08	4	0	7
9	R:R:N68	6.9875	4	2	9
10	R:R:D92	6.765	4	0	3
11	R:R:W93	10.7775	4	4	9
12	R:R:C100	9.085	4	4	9
13	R:R:R101	13.215	4	2	7
14	R:R:F105	4.745	4	2	5
15	R:R:F107	6.7675	4	1	6
16	R:R:M109	4.3825	4	2	5
17	R:R:Q112	6.822	5	1	7
18	R:R:Y126	6.29714	7	3	8
19	R:R:F127	5.21	4	3	5
20	R:R:W152	4.512	5	2	9
21	R:R:N175	9.174	5	4	3
22	R:R:F180	8.036	5	1	4
23	R:R:E190	6.6975	4	1	4
24	R:R:F193	9.43	4	1	5
25	R:R:F197	6.482	5	10	8
26	R:R:L201	2.952	5	10	6
27	R:R:I226	2.13	4	11	7
28	R:R:R251	6.3475	4	1	6
29	R:R:L257	6.4925	4	0	2
30	R:R:R270	4.75	4	0	2
31	R:R:F276	7.27	4	1	4
32	R:R:Y284	6.355	4	1	7
33	R:R:M285	4.525	4	0	5
34	R:R:D290	6.43	4	0	9
35	R:R:Y294	5.685	6	0	9
36	R:R:Y295	6.31	5	0	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F277	54.8916	12.81	Yes	No	0	0	5
2	R:R:F277	R:R:I178	16.007	3.77	No	No	0	5	3
3	R:R:I178	R:R:V20	12.1608	12.29	No	Yes	6	3	2
4	R:R:D273	R:R:F277	42.0159	2.39	No	No	0	4	5
5	R:R:D273	R:R:R270	30.92	3.57	No	Yes	0	4	2
6	R:R:D23	R:R:R270	18.5549	2.38	Yes	Yes	0	5	2
7	L:L:?1	R:R:Y284	96.8832	11.31	Yes	Yes	1	0	7
8	R:R:E37	R:R:Y284	100	3.37	No	Yes	0	7	7
9	R:R:E37	R:R:M285	98.5364	4.06	No	Yes	0	7	5
10	R:R:C243	R:R:M285	94.8604	3.24	No	Yes	0	8	5
11	R:R:C243	R:R:N286	94.2186	7.87	No	No	0	8	9
12	R:R:D290	R:R:N286	60.3326	12.12	Yes	No	0	9	9
13	R:R:D290	R:R:D73	25.4498	5.32	Yes	No	0	9	9
14	R:R:D73	R:R:N45	22.0801	13.46	No	No	0	9	9
15	R:R:F74	R:R:N45	41.6561	10.87	No	No	0	7	9
16	R:R:F74	R:R:L42	15.0199	4.87	No	No	0	7	6
17	R:R:F38	R:R:L42	10.0506	3.65	Yes	No	0	6	6
18	R:R:D290	R:R:P291	24.239	4.83	Yes	No	0	9	9
19	R:R:N45	R:R:P291	21.9926	3.26	No	No	0	9	9
20	R:R:F74	R:R:L49	24.842	6.09	No	No	0	7	7
21	R:R:L49	R:R:W50	22.4011	2.28	No	No	0	7	4
22	R:R:F54	R:R:W50	17.49	2	No	No	0	4	4
23	R:R:F54	R:R:H55	12.5401	3.39	No	No	0	4	5
24	R:R:F301	R:R:H55	10.0506	10.18	No	No	0	8	5
25	R:R:D290	R:R:Y294	15.4041	3.45	Yes	Yes	0	9	9
26	L:L:?1	R:R:F180	64.8109	7.47	Yes	Yes	1	0	4
27	R:R:F180	R:R:R111	55.7668	4.28	Yes	No	0	4	7
28	R:R:F193	R:R:R111	55.6598	17.1	Yes	No	0	5	7
29	R:R:F193	R:R:Q112	55.0715	3.51	Yes	Yes	1	5	7
30	R:R:Q112	R:R:T155	52.4798	7.09	Yes	No	0	7	7
31	R:R:T155	R:R:W152	43.3337	3.64	No	Yes	0	7	9
32	R:R:N68	R:R:W152	35.0336	4.52	Yes	Yes	2	9	9
33	R:R:F67	R:R:N68	30.8616	3.62	No	Yes	0	6	9
34	R:R:F67	R:R:W59	28.5763	9.02	No	No	0	6	6
35	R:R:L56	R:R:W59	21.4869	11.39	No	No	0	6	6
36	R:R:L56	R:R:R63	20.2421	9.72	No	Yes	0	6	7
37	L:L:?1	R:R:Y86	23.4027	9.25	Yes	No	0	0	5
38	R:R:W93	R:R:Y86	22.4011	7.72	Yes	No	0	9	5
39	R:R:F95	R:R:W93	11.7913	9.02	No	Yes	0	7	9
40	R:R:F95	R:R:P99	10.0506	11.56	No	No	0	7	5
41	R:R:M109	R:R:W152	12.5839	3.49	Yes	Yes	2	5	9
42	R:R:F244	R:R:N286	63.4688	12.08	No	No	0	9	9
43	R:R:F244	R:R:I115	47.35	6.28	No	No	0	9	8
44	R:R:I115	R:R:P200	46.3143	3.39	No	No	0	8	9
45	R:R:G113	R:R:T155	13.3181	1.82	No	No	0	6	7
46	R:R:G113	R:R:I116	12.0296	1.76	No	No	0	6	5
47	R:R:I116	R:R:L151	10.7313	5.71	No	No	0	5	7
48	R:R:P200	R:R:T119	44.2138	3.5	No	No	0	9	7
49	R:R:I203	R:R:T119	39.8959	4.56	No	No	0	6	7
50	R:R:C207	R:R:I203	38.7922	1.64	No	No	0	6	6
51	R:R:C207	R:R:Y126	37.6787	9.41	No	Yes	0	6	8
52	R:R:I211	R:R:Y126	22.4351	3.63	No	Yes	0	8	8
53	R:R:D273	R:R:I182	12.2484	11.2	No	No	0	4	2
54	R:R:F240	R:R:F244	21.3119	3.22	No	No	0	9	9
55	R:R:F197	R:R:F240	14.7039	3.22	Yes	No	10	8	9
56	R:R:I211	R:R:I233	19.9164	2.94	No	No	0	8	7
57	R:R:I212	R:R:I233	17.49	4.42	No	No	0	5	7
58	R:R:I212	R:R:I230	13.5953	7.36	No	No	0	5	5
59	R:R:R63	R:R:S300	11.5968	2.64	Yes	No	0	7	6
60	R:R:S298	R:R:S300	10.4298	1.63	No	No	0	8	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:V83	13.06	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y86	9.25	1	Yes	No	0	5	0	1
L:L:?1	R:R:L104	3.64	1	Yes	No	0	5	0	1
L:L:?1	R:R:F107	10.68	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:S179	5.27	1	Yes	No	0	5	0	1
L:L:?1	R:R:F180	7.47	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:F277	12.81	1	Yes	No	0	5	0	1
L:L:?1	R:R:L280	3.64	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y284	11.31	1	Yes	Yes	0	7	0	1
R:R:E37	R:R:Y284	3.37	0	No	Yes	7	7	2	1
R:R:L76	R:R:Y284	3.52	0	No	Yes	6	7	2	1
R:R:F107	R:R:V83	5.24	1	Yes	No	6	6	1	1
R:R:W93	R:R:Y86	7.72	4	Yes	No	9	5	2	1
R:R:F107	R:R:V103	3.93	1	Yes	No	6	5	1	2
R:R:L104	R:R:S179	4.5	1	No	No	5	5	1	1
R:R:F107	R:R:Y284	7.22	1	Yes	Yes	6	7	1	1
R:R:F180	R:R:R111	4.28	1	Yes	No	4	7	1	2
R:R:R111	R:R:T283	3.88	0	No	No	7	8	2	2
R:R:F277	R:R:I178	3.77	0	No	No	5	3	1	2
R:R:F180	R:R:S179	3.96	1	Yes	No	4	5	1	1
R:R:F180	R:R:H189	16.97	1	Yes	No	4	5	1	2
R:R:F180	R:R:F276	7.5	1	Yes	Yes	4	4	1	2
R:R:F276	R:R:L280	4.87	1	Yes	No	4	5	2	1
R:R:L280	R:R:T283	8.84	0	No	No	5	8	1	2
L:L:?1	R:R:L34	2.43	1	Yes	No	0	8	0	1
R:R:D273	R:R:F277	2.39	0	No	No	4	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9JKS_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	269
Number of Links	302
Number of Hubs	36
Number of Links mediated by Hubs	142
Number of Communities	11
Number of Nodes involved in Communities	59
Number of Links involved in Communities	73

Path Summary
Number Of Nodes in MetaPath	61
Number Of Links MetaPath	60
Number of Shortest Paths	39959
Length Of Smallest Path	3
Average Path Length	14.6974
Length of Longest Path	38
Minimum Path Strength	1.19
Average Path Strength	6.46229
Maximum Path Strength	18.99
Minimum Path Correlation	0.7
Average Path Correlation	0.917109
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	44.6759
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.8791
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49019
Sequence	>9JKS_nogp_Chain_R N C C V F R D D F I A K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F V M D Y Y V R R S D W K F G D I P C R L V L F M F A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N W T A A I I S C L L W G I T V G L T V H L L K K K L L I Q N G T A N V C I S F S I C H T F R W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I H I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IHJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.07	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-		3.07	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHK	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-	-	3.21	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	9JKS	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 44250176	-	Gi1/β1/γ2	3.31	2025-10-29	To be published
	9JKS (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 44250176	-		3.31	2025-10-29	To be published
	9JKT	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	(2R)-2-hydroxy-3-phenylpropanoic acid	-	Gi1/β1/γ2	3.05	2025-10-29	To be published
	9JKT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	(2R)-2-hydroxy-3-phenylpropanoic acid	-		3.05	2025-10-29	To be published
	9JKV	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 2736690	-	Gi1/β1/γ2	3.26	2025-10-29	To be published
	9JKV (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 2736690	-		3.26	2025-10-29	To be published
	9JKX	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.18	2025-10-29	To be published
	9JKX (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-		3.18	2025-10-29	To be published
	8JEF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 11367166	-	Gi1/β1/γ2	2.96	2024-12-18	doi.org/10.1016/j.celrep.2024.114895
	8JEF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 11367166	-		2.96	2024-12-18	doi.org/10.1016/j.celrep.2024.114895
	9KT6	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.01	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT6 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-		3.01	2025-12-10	10.1021/acs.jmedchem.4c02567
	9JIC	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	-	-	Gi1/β1/γ2	3.4	2025-12-17	10.1016/j.celrep.2024.114895
	9JIC (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	-	-		3.4	2025-12-17	10.1016/j.celrep.2024.114895
	9JID	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.78	2025-12-17	10.1016/j.celrep.2024.114895
	9JID (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Niacin	-		2.78	2025-12-17	10.1016/j.celrep.2024.114895

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9JKS_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.