psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:V83	6.53	Yes	No	0	0	6
2	L:L:?1	R:R:L104	3.64	Yes	No	0	0	5
3	L:L:?1	R:R:F107	17.08	Yes	No	0	0	6
4	L:L:?1	R:R:R111	13.85	Yes	No	1	0	7
5	L:L:?1	R:R:I178	7.51	Yes	Yes	0	0	3
6	L:L:?1	R:R:F180	13.88	Yes	Yes	0	0	4
7	L:L:?1	R:R:L280	12.13	Yes	No	0	0	5
8	L:L:?1	R:R:T283	5.17	Yes	No	1	0	8
9	L:L:?1	R:R:Y284	8.22	Yes	Yes	1	0	7
10	R:R:C18	R:R:C183	7.28	No	No	0	8	1
11	R:R:C19	R:R:C266	7.28	No	No	0	3	6
12	R:R:F21	R:R:I178	3.77	No	Yes	0	3	3
13	R:R:D273	R:R:F21	5.97	No	No	9	4	3
14	R:R:F21	R:R:F277	5.36	No	Yes	9	3	5
15	R:R:R22	R:R:R270	4.26	No	No	0	5	2
16	R:R:D23	R:R:F25	7.17	No	No	0	5	5
17	R:R:D23	R:R:I26	8.4	No	Yes	0	5	4
18	R:R:D24	R:R:F25	7.17	No	No	0	4	5
19	R:R:I26	R:R:L30	8.56	Yes	Yes	0	4	6
20	R:R:F277	R:R:I26	8.79	Yes	Yes	0	5	4
21	R:R:I26	R:R:I278	2.94	Yes	No	0	4	5
22	R:R:A27	R:R:R90	6.91	No	No	0	4	3
23	R:R:K28	R:R:R90	7.43	No	No	0	3	3
24	R:R:L30	R:R:V33	4.47	Yes	No	3	6	6
25	R:R:L30	R:R:L34	5.54	Yes	Yes	3	6	8
26	R:R:L30	R:R:Y87	4.69	Yes	Yes	3	6	5
27	R:R:L30	R:R:S281	7.51	Yes	No	3	6	5
28	R:R:P31	R:R:P32	7.79	Yes	No	0	6	4
29	R:R:M84	R:R:P31	3.35	No	Yes	3	7	6
30	R:R:P31	R:R:Y87	15.3	Yes	Yes	3	6	5
31	R:R:P31	R:R:V88	3.53	Yes	Yes	3	6	3
32	R:R:L34	R:R:V33	2.98	Yes	No	3	8	6
33	R:R:L34	R:R:V83	4.47	Yes	No	0	8	6
34	R:R:L34	R:R:Y87	14.07	Yes	Yes	3	8	5
35	R:R:L34	R:R:S281	3	Yes	No	3	8	5
36	R:R:E37	R:R:L36	5.3	No	No	0	7	4
37	R:R:E37	R:R:Y284	7.86	No	Yes	0	7	7
38	R:R:E37	R:R:M288	10.83	No	No	0	7	6
39	R:R:F38	R:R:L80	14.61	No	No	0	6	8
40	R:R:F38	R:R:P81	8.67	No	No	0	6	9
41	R:R:F40	R:R:M288	11.2	No	No	0	5	6
42	R:R:I77	R:R:L42	2.85	Yes	No	0	5	6
43	R:R:G44	R:R:P291	4.06	No	No	0	7	9
44	R:R:G46	R:R:N45	3.39	No	Yes	0	1	9
45	R:R:D73	R:R:N45	8.08	Yes	Yes	1	9	9
46	R:R:F74	R:R:N45	14.5	No	Yes	0	7	9
47	R:R:I77	R:R:N45	5.66	Yes	Yes	1	5	9
48	R:R:F52	R:R:W59	5.01	No	No	0	7	6
49	R:R:F52	R:R:Y295	4.13	No	Yes	0	7	5
50	R:R:C53	R:R:F54	13.97	No	No	0	2	4
51	R:R:F54	R:R:H55	11.31	No	No	0	4	5
52	R:R:R63	R:R:W59	4	No	No	0	7	6
53	R:R:F67	R:R:W59	4.01	Yes	No	0	6	6
54	R:R:F65	R:R:S61	5.28	No	No	0	6	7
55	R:R:I139	R:R:S61	4.64	No	No	0	7	7
56	R:R:D124	R:R:S62	2.94	No	No	0	8	8
57	R:R:L66	R:R:R63	3.64	No	No	0	8	7
58	R:R:I64	R:R:N141	2.83	No	No	0	6	3
59	R:R:F65	R:R:V120	7.87	No	No	0	6	6
60	R:R:L66	R:R:Y294	3.52	No	Yes	2	8	9
61	R:R:L66	R:R:Y295	9.38	No	Yes	2	8	5
62	R:R:F67	R:R:N68	3.62	Yes	Yes	0	6	9
63	R:R:F67	R:R:V71	5.24	Yes	No	0	6	5
64	R:R:F117	R:R:N68	13.29	No	Yes	6	7	9
65	R:R:N68	R:R:S148	4.47	Yes	No	0	9	6
66	R:R:N68	R:R:W152	4.52	Yes	Yes	6	9	9
67	R:R:L69	R:R:S114	3	No	No	0	9	9
68	R:R:D290	R:R:L69	4.07	No	No	0	9	9
69	R:R:D73	R:R:I77	4.2	Yes	Yes	1	9	5
70	R:R:D73	R:R:S287	4.42	Yes	No	1	9	8
71	R:R:L75	R:R:M106	2.83	No	No	6	6	5
72	R:R:L75	R:R:M109	5.65	No	Yes	6	6	5
73	R:R:F107	R:R:L76	3.65	No	Yes	0	6	6
74	R:R:L76	R:R:N110	16.48	Yes	No	0	6	8
75	R:R:L76	R:R:Y284	4.69	Yes	Yes	1	6	7
76	R:R:L76	R:R:S287	3	Yes	No	1	6	8
77	R:R:C79	R:R:M106	6.48	No	No	0	6	5
78	R:R:L80	R:R:V83	4.47	No	No	0	8	6
79	R:R:F82	R:R:V103	14.42	No	No	0	6	5
80	R:R:M84	R:R:V88	4.56	No	Yes	3	7	3
81	R:R:D85	R:R:V88	4.38	No	Yes	0	4	3
82	R:R:D85	R:R:R89	3.57	No	No	0	4	4
83	R:R:W93	R:R:Y86	4.82	Yes	No	8	9	5
84	R:R:C177	R:R:Y86	9.41	No	No	8	9	5
85	R:R:V88	R:R:Y87	3.79	Yes	Yes	3	3	5
86	R:R:D92	R:R:R89	4.76	No	No	0	3	4
87	R:R:D92	R:R:N175	12.12	No	No	0	3	3
88	R:R:C100	R:R:W93	7.84	No	Yes	8	9	9
89	R:R:N175	R:R:W93	5.65	No	Yes	0	3	9
90	R:R:C177	R:R:W93	7.84	No	Yes	8	9	9
91	R:R:F95	R:R:K94	6.2	No	No	4	7	3
92	R:R:K94	R:R:P99	5.02	No	No	4	3	5
93	R:R:F95	R:R:P99	2.89	No	No	4	7	5
94	R:R:D97	R:R:I98	9.8	No	No	4	3	1
95	R:R:D97	R:R:R101	5.96	No	Yes	4	3	7
96	R:R:D97	R:R:Q170	3.92	No	Yes	4	3	2
97	R:R:I98	R:R:P99	3.39	No	No	4	1	5
98	R:R:I98	R:R:R101	10.02	No	Yes	4	1	7
99	R:R:C100	R:R:C177	7.28	No	No	8	9	9
100	R:R:L102	R:R:R101	3.64	No	Yes	0	4	7
101	R:R:K166	R:R:R101	6.19	No	Yes	4	5	7
102	R:R:Q170	R:R:R101	11.68	Yes	Yes	4	2	7
103	R:R:F105	R:R:T159	3.89	No	Yes	0	5	6
104	R:R:M106	R:R:M109	2.89	No	Yes	6	5	5
105	R:R:A108	R:R:T159	3.36	No	Yes	0	5	6
106	R:R:M109	R:R:W152	4.65	Yes	Yes	6	5	9
107	R:R:M109	R:R:T159	3.01	Yes	Yes	0	5	6
108	R:R:R111	R:R:T283	9.06	No	No	1	7	8
109	R:R:L158	R:R:Q112	3.99	No	Yes	0	4	7
110	R:R:Q112	R:R:T159	2.83	Yes	Yes	0	7	6
111	R:R:M192	R:R:Q112	8.16	No	Yes	10	5	7
112	R:R:E196	R:R:Q112	16.57	No	Yes	10	6	7
113	R:R:I115	R:R:P200	3.39	No	No	0	8	9
114	R:R:F244	R:R:I115	10.05	Yes	No	0	9	8
115	R:R:I116	R:R:L151	4.28	No	No	0	5	7
116	R:R:F117	R:R:W152	8.02	No	Yes	6	7	9
117	R:R:L118	R:R:Y294	5.86	No	Yes	0	8	9
118	R:R:I203	R:R:T119	4.56	No	No	0	6	7
119	R:R:I204	R:R:T119	3.04	Yes	No	0	8	7
120	R:R:R125	R:R:V121	5.23	No	No	0	9	8
121	R:R:A122	R:R:I204	4.87	No	Yes	0	9	8
122	R:R:D124	R:R:R128	9.53	No	No	0	8	8
123	R:R:F232	R:R:R125	9.62	Yes	No	0	7	9
124	R:R:F127	R:R:Y126	4.13	No	Yes	5	5	8
125	R:R:V130	R:R:Y126	11.36	No	Yes	5	7	8
126	R:R:H131	R:R:Y126	3.27	No	Yes	5	6	8
127	R:R:F206	R:R:Y126	6.19	No	Yes	5	3	8
128	R:R:C207	R:R:Y126	9.41	No	Yes	0	6	8
129	R:R:R210	R:R:Y126	7.2	No	Yes	5	4	8
130	R:R:I211	R:R:Y126	3.63	No	Yes	0	8	8
131	R:R:F127	R:R:H134	5.66	No	No	5	5	5
132	R:R:F127	R:R:L136	10.96	No	No	5	5	4
133	R:R:N137	R:R:R128	3.62	No	No	0	4	8
134	R:R:I211	R:R:V129	6.14	No	No	0	8	8
135	R:R:L215	R:R:V129	2.98	No	No	0	8	8
136	R:R:H131	R:R:V130	8.3	No	No	5	6	7
137	R:R:S214	R:R:V130	3.23	No	No	0	5	7
138	R:R:H134	R:R:L136	3.86	No	No	5	5	4
139	R:R:S140	R:R:T143	4.8	No	No	0	6	3
140	R:R:I146	R:R:W142	11.74	No	No	0	3	4
141	R:R:I147	R:R:L151	2.85	No	No	0	4	7
142	R:R:I154	R:R:L150	5.71	No	No	0	4	3
143	R:R:T155	R:R:W152	3.64	No	Yes	0	7	9
144	R:R:I154	R:R:L158	4.28	No	No	0	4	4
145	R:R:G157	R:R:V160	3.68	No	No	0	4	4
146	R:R:L163	R:R:V160	2.98	No	No	0	4	4
147	R:R:H161	R:R:K165	5.24	Yes	No	0	8	4
148	R:R:H161	R:R:R187	6.77	Yes	No	0	8	1
149	R:R:H161	R:R:W188	3.17	Yes	No	0	8	4
150	R:R:H161	R:R:H189	22.69	Yes	No	0	8	5
151	R:R:I169	R:R:L162	8.56	No	No	0	1	3
152	R:R:H189	R:R:L162	3.86	No	No	0	5	3
153	R:R:K164	R:R:K166	5.75	No	No	0	4	5
154	R:R:K166	R:R:Q170	9.49	No	Yes	4	5	2
155	R:R:G172	R:R:N171	5.09	No	No	0	3	2
156	R:R:T173	R:R:V176	4.76	No	No	0	5	1
157	R:R:I178	R:R:S181	4.64	Yes	No	0	3	5
158	R:R:F180	R:R:S179	3.96	Yes	No	0	4	5
159	R:R:F180	R:R:R251	3.21	Yes	Yes	0	4	6
160	R:R:F180	R:R:F276	8.57	Yes	No	0	4	4
161	R:R:I182	R:R:Y269	4.84	No	Yes	0	2	4
162	R:R:D273	R:R:I182	5.6	No	No	0	4	2
163	R:R:H184	R:R:L258	20.57	No	No	12	3	3
164	R:R:H184	R:R:T263	5.48	No	No	12	3	3
165	R:R:R187	R:R:T185	9.06	No	No	0	1	4
166	R:R:E190	R:R:F186	8.16	No	Yes	0	4	3
167	R:R:F186	R:R:F255	4.29	Yes	No	0	3	5
168	R:R:H189	R:R:M192	3.94	No	No	0	5	5
169	R:R:E190	R:R:R251	9.3	No	Yes	0	4	6
170	R:R:E196	R:R:M192	9.47	No	No	10	6	5
171	R:R:E196	R:R:F193	7	No	No	0	6	5
172	R:R:F193	R:R:S247	7.93	No	No	0	5	6
173	R:R:F193	R:R:R251	4.28	No	Yes	0	5	6
174	R:R:L195	R:R:L199	4.15	No	No	0	5	5
175	R:R:F197	R:R:F198	10.72	Yes	No	0	8	4
176	R:R:F197	R:R:L201	3.65	Yes	Yes	7	8	6
177	R:R:F197	R:R:F240	5.36	Yes	Yes	7	8	9
178	R:R:F197	R:R:F244	3.22	Yes	Yes	7	8	9
179	R:R:F197	R:R:L245	4.87	Yes	No	0	8	5
180	R:R:F197	R:R:V248	11.8	Yes	No	0	8	8
181	R:R:L199	R:R:P200	3.28	No	No	0	5	9
182	R:R:F240	R:R:P200	2.89	Yes	No	0	9	9
183	R:R:F240	R:R:L201	6.09	Yes	Yes	7	9	6
184	R:R:L201	R:R:V241	2.98	Yes	No	0	6	4
185	R:R:F240	R:R:I204	3.77	Yes	Yes	0	9	8
186	R:R:F206	R:R:R210	7.48	No	No	5	3	4
187	R:R:I233	R:R:S208	9.29	No	No	0	7	8
188	R:R:M234	R:R:S208	3.07	No	No	0	5	8
189	R:R:R210	R:R:W213	3	No	No	0	4	4
190	R:R:I211	R:R:I233	2.94	No	No	0	8	7
191	R:R:I212	R:R:I230	5.89	No	Yes	0	5	5
192	R:R:I212	R:R:I233	2.94	No	No	0	5	7
193	R:R:Q217	R:R:W213	4.38	No	No	0	5	4
194	R:R:I226	R:R:L215	4.28	Yes	No	11	7	8
195	R:R:I230	R:R:L215	2.85	Yes	No	11	5	8
196	R:R:D221	R:R:R216	10.72	No	No	0	3	4
197	R:R:M220	R:R:R218	3.72	No	No	0	3	6
198	R:R:I226	R:R:M220	5.83	Yes	No	0	7	3
199	R:R:I226	R:R:I230	2.94	Yes	Yes	11	7	5
200	R:R:K227	R:R:T231	6.01	No	No	0	5	6
201	R:R:F232	R:R:V236	5.24	Yes	No	2	7	7
202	R:R:F232	R:R:Y294	4.13	Yes	Yes	2	7	9
203	R:R:F232	R:R:F296	7.5	Yes	No	0	7	7
204	R:R:V236	R:R:V293	3.21	No	Yes	2	7	7
205	R:R:V236	R:R:Y294	10.09	No	Yes	2	7	9
206	R:R:L289	R:R:V239	4.47	Yes	No	2	7	7
207	R:R:V239	R:R:V293	4.81	No	Yes	2	7	7
208	R:R:F240	R:R:F244	4.29	Yes	Yes	7	9	9
209	R:R:C243	R:R:F244	11.17	No	Yes	7	8	9
210	R:R:C243	R:R:M285	4.86	No	Yes	0	8	5
211	R:R:C243	R:R:N286	6.3	No	No	7	8	9
212	R:R:F244	R:R:N286	7.25	Yes	No	7	9	9
213	R:R:L245	R:R:V249	2.98	No	No	0	5	5
214	R:R:P246	R:R:T279	3.5	No	No	0	9	6
215	R:R:F282	R:R:P246	4.33	No	No	0	7	9
216	R:R:S247	R:R:V248	3.23	No	No	0	6	8
217	R:R:A275	R:R:V250	3.39	No	No	0	5	4
218	R:R:T279	R:R:V250	7.93	No	No	0	6	4
219	R:R:I254	R:R:R251	5.01	No	Yes	0	5	6
220	R:R:H253	R:R:L257	9	No	No	13	5	2
221	R:R:H253	R:R:V272	5.54	No	Yes	13	5	4
222	R:R:I254	R:R:V272	3.07	No	Yes	0	5	4
223	R:R:L257	R:R:T260	2.95	No	No	0	2	1
224	R:R:L257	R:R:V272	4.47	No	Yes	13	2	4
225	R:R:L258	R:R:T263	2.95	No	No	12	3	3
226	R:R:L258	R:R:Y269	7.03	No	Yes	0	3	4
227	R:R:S261	R:R:T260	3.2	No	No	0	4	1
228	R:R:Q264	R:R:T263	2.83	No	No	0	1	3
229	R:R:E267	R:R:N265	10.52	No	No	0	1	4
230	R:R:C266	R:R:Y269	4.03	No	Yes	0	6	4
231	R:R:D273	R:R:F277	16.72	No	Yes	9	4	5
232	R:R:F276	R:R:T279	5.19	No	No	0	4	6
233	R:R:F276	R:R:L280	13.4	No	No	0	4	5
234	R:R:I278	R:R:S281	3.1	No	No	0	5	5
235	R:R:F282	R:R:M285	6.22	No	Yes	0	7	5
236	R:R:T283	R:R:Y284	12.48	No	Yes	1	8	7
237	R:R:S287	R:R:Y284	6.36	No	Yes	1	8	7
238	R:R:L289	R:R:M285	2.83	Yes	Yes	0	7	5
239	R:R:D290	R:R:N286	9.42	No	No	0	9	9
240	R:R:L289	R:R:M288	2.83	Yes	No	0	7	6
241	R:R:L289	R:R:V293	2.98	Yes	Yes	2	7	7
242	R:R:V293	R:R:Y294	6.31	Yes	Yes	2	7	9
243	R:R:Y294	R:R:Y295	3.97	Yes	Yes	2	9	5
244	R:R:F301	R:R:P299	2.89	No	No	0	8	5
245	R:R:F301	R:R:S300	3.96	No	No	0	8	6
246	R:R:G96	R:R:W93	2.81	No	Yes	0	8	9
247	R:R:D221	R:R:I230	2.8	No	Yes	0	3	5
248	R:R:A191	R:R:F186	2.77	No	Yes	0	2	3
249	R:R:I116	R:R:Q112	2.74	No	Yes	0	5	7
250	R:R:A70	R:R:Y295	2.67	No	Yes	0	8	5
251	R:R:H223	R:R:I226	2.65	No	Yes	0	3	7
252	R:R:R228	R:R:S298	2.64	No	No	0	7	8
253	R:R:F107	R:R:V103	2.62	No	No	0	6	5
254	R:R:A72	R:R:W152	2.59	No	Yes	0	8	9
255	R:R:V268	R:R:Y269	2.52	No	Yes	0	1	4
256	R:R:S140	R:R:W142	2.47	No	No	0	6	4
257	R:R:F67	R:R:L49	2.44	Yes	No	0	6	7
258	R:R:F186	R:R:L194	2.44	Yes	No	0	3	4
259	R:R:F277	R:R:L274	2.44	Yes	No	0	5	3
260	R:R:T260	R:R:W256	2.43	No	No	0	1	4
261	R:R:D92	R:R:R90	2.38	No	No	0	3	3
262	R:R:L49	R:R:W50	2.28	No	No	0	7	4
263	R:R:G262	R:R:S261	1.86	No	No	0	3	4
264	R:R:G153	R:R:V156	1.84	No	No	0	4	4
265	R:R:G113	R:R:T155	1.82	No	No	0	6	7
266	R:R:P299	R:R:S298	1.78	No	No	0	5	8
267	R:R:G41	R:R:I77	1.76	No	Yes	0	8	5
268	R:R:G35	R:R:M84	1.75	No	No	0	5	7
269	R:R:C149	R:R:S148	1.72	No	No	0	3	6
270	R:R:C183	R:R:S181	1.72	No	No	0	1	5
271	R:R:G44	R:R:L43	1.71	No	No	0	7	4
272	R:R:A144	R:R:S61	1.71	No	No	0	8	7
273	R:R:C207	R:R:V123	1.71	No	No	0	6	6
274	R:R:A145	R:R:S148	1.71	No	No	0	4	6
275	R:R:G202	R:R:L201	1.71	No	Yes	0	3	6
276	R:R:C79	R:R:I78	1.64	No	No	0	6	4
277	R:R:C207	R:R:I203	1.64	No	No	0	6	6
278	R:R:S297	R:R:S298	1.63	No	No	0	6	8
279	R:R:A144	R:R:I64	1.62	No	No	0	8	6
280	R:R:A237	R:R:I204	1.62	No	Yes	0	7	8
281	R:R:S271	R:R:V272	1.62	No	Yes	0	2	4
282	R:R:D73	R:R:P291	1.61	Yes	No	0	9	9
283	R:R:D290	R:R:P291	1.61	No	No	0	9	9
284	R:R:V235	R:R:V239	1.6	No	No	2	5	7
285	R:R:V235	R:R:V293	1.6	No	Yes	2	5	7
286	R:R:T155	R:R:V156	1.59	No	No	0	7	4
287	R:R:A237	R:R:L205	1.58	No	No	0	7	4
288	R:R:I116	R:R:V120	1.54	No	No	0	5	6
289	R:R:I178	R:R:V176	1.54	Yes	No	0	3	1
290	R:R:K57	R:R:S58	1.53	No	No	0	6	6
291	R:R:H131	R:R:P132	1.53	No	No	0	6	8
292	R:R:H133	R:R:P132	1.53	No	No	0	5	8
293	R:R:I139	R:R:T143	1.52	No	No	0	7	3
294	R:R:I147	R:R:T143	1.52	No	No	0	4	3
295	R:R:L56	R:R:S58	1.5	No	No	0	6	6
296	R:R:N171	R:R:V176	1.48	No	No	0	2	1
297	R:R:I238	R:R:I242	1.47	No	No	0	4	5
298	R:R:A135	R:R:H134	1.46	No	No	0	5	5
299	R:R:I242	R:R:M285	1.46	No	Yes	0	5	5
300	R:R:I226	R:R:K225	1.45	Yes	No	0	7	5
301	R:R:I39	R:R:L36	1.43	No	No	0	5	4
302	R:R:I39	R:R:L43	1.43	No	No	0	5	4
303	R:R:I51	R:R:L56	1.43	No	No	0	7	6
304	R:R:I169	R:R:Q170	1.37	No	Yes	0	1	2
305	R:R:R125	R:R:S62	1.32	No	No	0	9	8
306	R:R:D221	R:R:Q219	1.31	No	No	0	3	4
307	R:R:F232	R:R:T231	1.3	Yes	No	0	7	6
308	R:R:H55	R:R:L56	1.29	No	No	0	5	6
309	R:R:S91	R:R:Y86	1.27	No	No	0	4	5
310	R:R:K60	R:R:R63	1.24	No	No	0	7	7
311	R:R:L168	R:R:R187	1.21	No	No	0	4	1
312	R:R:N265	R:R:Y269	1.16	No	Yes	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.77889	9	1	0
2	R:R:I26	7.1725	4	0	4
3	R:R:L30	6.154	5	3	6
4	R:R:P31	7.4925	4	3	6
5	R:R:L34	6.012	5	3	8
6	R:R:N45	7.9075	4	1	9
7	R:R:F67	3.8275	4	0	6
8	R:R:N68	6.475	4	6	9
9	R:R:D73	4.5775	4	1	9
10	R:R:L76	6.955	4	1	6
11	R:R:I77	3.6175	4	1	5
12	R:R:Y87	9.4625	4	3	5
13	R:R:V88	4.065	4	3	3
14	R:R:W93	5.792	5	8	9
15	R:R:R101	7.498	5	4	7
16	R:R:M109	4.05	4	6	5
17	R:R:Q112	6.858	5	10	7
18	R:R:Y126	6.45571	7	5	8
19	R:R:W152	4.684	5	6	9
20	R:R:T159	3.2725	4	0	6
21	R:R:H161	9.4675	4	0	8
22	R:R:Q170	6.615	4	4	2
23	R:R:I178	4.365	4	0	3
24	R:R:F180	7.405	4	0	4
25	R:R:F186	4.415	4	0	3
26	R:R:F197	6.60333	6	7	8
27	R:R:L201	3.6075	4	7	6
28	R:R:I204	3.325	4	0	8
29	R:R:I226	3.43	5	11	7
30	R:R:I230	3.62	4	11	5
31	R:R:F232	5.558	5	2	7
32	R:R:F240	4.48	5	7	9
33	R:R:F244	7.196	5	7	9
34	R:R:R251	5.45	4	0	6
35	R:R:Y269	3.916	5	0	4
36	R:R:V272	3.675	4	13	4
37	R:R:F277	8.3275	4	9	5
38	R:R:Y284	7.922	5	1	7
39	R:R:M285	3.8425	4	0	5
40	R:R:L289	3.2775	4	2	7
41	R:R:V293	3.782	5	2	7
42	R:R:Y294	5.64667	6	2	9
43	R:R:Y295	5.0375	4	2	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:I178	51.1032	7.51	Yes	Yes	0	0	3
2	R:R:F21	R:R:I178	36.3293	3.77	No	Yes	0	3	3
3	R:R:D273	R:R:F21	23.322	5.97	No	No	9	4	3
4	R:R:D273	R:R:I182	24.2632	5.6	No	No	0	4	2
5	R:R:I182	R:R:Y269	22.1339	4.84	No	Yes	0	2	4
6	L:L:?1	R:R:V83	64.6582	6.53	Yes	No	0	0	6
7	R:R:L34	R:R:V83	57.846	4.47	Yes	No	0	8	6
8	R:R:I26	R:R:L30	11.4411	8.56	Yes	Yes	0	4	6
9	R:R:D23	R:R:I26	12.3283	8.4	No	Yes	0	5	4
10	R:R:F21	R:R:F277	11.6031	5.36	No	Yes	9	3	5
11	R:R:F277	R:R:I26	11.3717	8.79	Yes	Yes	0	5	4
12	R:R:L34	R:R:Y87	41.3054	14.07	Yes	Yes	3	8	5
13	R:R:V88	R:R:Y87	34.5549	3.79	Yes	Yes	3	3	5
14	R:R:D85	R:R:V88	28.5758	4.38	No	Yes	0	4	3
15	R:R:D85	R:R:R89	26.4697	3.57	No	No	0	4	4
16	R:R:D92	R:R:R89	24.3481	4.76	No	No	0	3	4
17	L:L:?1	R:R:Y284	57.7766	8.22	Yes	Yes	1	0	7
18	R:R:E37	R:R:Y284	46.5437	7.86	No	Yes	0	7	7
19	R:R:E37	R:R:M288	45.0856	10.83	No	No	0	7	6
20	R:R:S287	R:R:Y284	20.1975	6.36	No	Yes	1	8	7
21	R:R:D73	R:R:S287	21.7482	4.42	Yes	No	1	9	8
22	R:R:D73	R:R:P291	13.9176	1.61	Yes	No	0	9	9
23	R:R:L289	R:R:M288	44.9159	2.83	Yes	No	0	7	6
24	R:R:L289	R:R:V293	62.9147	2.98	Yes	Yes	2	7	7
25	R:R:V293	R:R:Y294	44.8233	6.31	Yes	Yes	2	7	9
26	R:R:L66	R:R:Y294	20.6758	3.52	No	Yes	2	8	9
27	R:R:L66	R:R:R63	19.6652	3.64	No	No	0	8	7
28	R:R:R63	R:R:W59	17.7982	4	No	No	0	7	6
29	R:R:Y294	R:R:Y295	20.4752	3.97	Yes	Yes	2	9	5
30	L:L:?1	R:R:F180	98.2024	13.88	Yes	Yes	0	0	4
31	R:R:F180	R:R:R251	100	3.21	Yes	Yes	0	4	6
32	R:R:F193	R:R:R251	99.7763	4.28	No	Yes	0	5	6
33	R:R:E196	R:R:F193	94.3836	7	No	No	0	6	5
34	R:R:E196	R:R:Q112	57.792	16.57	No	Yes	10	6	7
35	R:R:Q112	R:R:T159	48.5187	2.83	Yes	Yes	0	7	6
36	R:R:M109	R:R:T159	44.6536	3.01	Yes	Yes	0	5	6
37	R:R:M109	R:R:W152	38.366	4.65	Yes	Yes	6	5	9
38	R:R:N68	R:R:W152	29.3782	4.52	Yes	Yes	6	9	9
39	R:R:F67	R:R:N68	26.5931	3.62	Yes	Yes	0	6	9
40	R:R:F67	R:R:W59	33.2048	4.01	Yes	No	0	6	6
41	R:R:F52	R:R:Y295	18.3228	4.13	No	Yes	0	7	5
42	R:R:F52	R:R:W59	17.5359	5.01	No	No	0	7	6
43	R:R:I116	R:R:Q112	32.3407	2.74	No	Yes	0	5	7
44	R:R:I116	R:R:V120	15.1443	1.54	No	No	0	5	6
45	R:R:F65	R:R:V120	12.9995	7.87	No	No	0	6	6
46	R:R:F65	R:R:S61	11.0477	5.28	No	No	0	6	7
47	R:R:I116	R:R:L151	15.314	4.28	No	No	0	5	7
48	R:R:I147	R:R:L151	13.1693	2.85	No	No	0	4	7
49	R:R:I147	R:R:T143	11.0477	1.52	No	No	0	4	3
50	R:R:V236	R:R:V293	16.3555	3.21	No	Yes	2	7	7
51	R:R:F232	R:R:V236	14.5271	5.24	Yes	No	2	7	7
52	R:R:F232	R:R:R125	24.0164	9.62	Yes	No	0	7	9
53	R:R:R125	R:R:S62	16.3864	1.32	No	No	0	9	8
54	R:R:D124	R:R:S62	12.5289	2.94	No	No	0	8	8
55	R:R:F232	R:R:Y294	25.3587	4.13	Yes	Yes	2	7	9
56	R:R:D290	R:R:P291	15.2214	1.61	No	No	0	9	9
57	R:R:D92	R:R:N175	15.7075	12.12	No	No	0	3	3
58	R:R:N175	R:R:W93	13.5087	5.65	No	Yes	0	3	9
59	R:R:E196	R:R:M192	35.4961	9.47	No	No	10	6	5
60	R:R:H189	R:R:M192	47.1609	3.94	No	No	0	5	5
61	R:R:H189	R:R:L162	33.9608	3.86	No	No	0	5	3
62	R:R:I169	R:R:L162	32.0707	8.56	No	No	0	1	3
63	R:R:I169	R:R:Q170	30.2345	1.37	No	Yes	0	1	2
64	R:R:D97	R:R:Q170	10.8471	3.92	No	Yes	4	3	2
65	R:R:I98	R:R:P99	13.1384	3.39	No	No	4	1	5
66	R:R:Q170	R:R:R101	12.9995	11.68	Yes	Yes	4	2	7
67	R:R:F193	R:R:S247	74.1861	7.93	No	No	0	5	6
68	R:R:S247	R:R:V248	73.6383	3.23	No	No	0	6	8
69	R:R:F197	R:R:V248	73.2372	11.8	Yes	No	0	8	8
70	R:R:F197	R:R:F244	14.7585	3.22	Yes	Yes	7	8	9
71	R:R:L289	R:R:M285	36.9696	2.83	Yes	Yes	0	7	5
72	R:R:C243	R:R:M285	37.5868	4.86	No	Yes	0	8	5
73	R:R:C243	R:R:F244	34.1151	11.17	No	Yes	7	8	9
74	R:R:D290	R:R:N286	17.5127	9.42	No	No	0	9	9
75	R:R:F244	R:R:N286	14.9668	7.25	Yes	No	7	9	9
76	R:R:F197	R:R:F240	55.5701	5.36	Yes	Yes	7	8	9
77	R:R:F240	R:R:I204	80.898	3.77	Yes	Yes	0	9	8
78	R:R:I204	R:R:T119	74.2941	3.04	Yes	No	0	8	7
79	R:R:I203	R:R:T119	72.6045	4.56	No	No	0	6	7
80	R:R:C207	R:R:I203	70.8996	1.64	No	No	0	6	6
81	R:R:C207	R:R:Y126	67.4433	9.41	No	Yes	0	6	8
82	R:R:I211	R:R:Y126	41.6988	3.63	No	Yes	0	8	8
83	R:R:I211	R:R:V129	22.9748	6.14	No	No	0	8	8
84	R:R:L215	R:R:V129	20.8996	2.98	No	No	0	8	8
85	R:R:H161	R:R:H189	12.7141	22.69	Yes	No	0	8	5
86	R:R:E190	R:R:R251	10.4691	9.3	No	Yes	0	4	6
87	R:R:I211	R:R:I233	16.8261	2.94	No	No	0	8	7
88	R:R:I212	R:R:I233	10.8471	2.94	No	No	0	5	7
89	R:R:D221	R:R:I230	12.9995	2.8	No	Yes	0	3	5
90	R:R:I226	R:R:L215	10.4613	4.28	Yes	No	11	7	8
91	R:R:F276	R:R:T279	11.0477	5.19	No	No	0	4	6
92	R:R:I254	R:R:R251	19.3643	5.01	No	Yes	0	5	6
93	R:R:I254	R:R:V272	17.2736	3.07	No	Yes	0	5	4
94	R:R:L257	R:R:V272	10.8702	4.47	No	Yes	13	2	4
95	R:R:F240	R:R:F244	32.063	4.29	Yes	Yes	7	9	9
96	R:R:M192	R:R:Q112	13.5627	8.16	No	Yes	10	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:V83	6.53	1	Yes	No	0	6	0	1
L:L:?1	R:R:L104	3.64	1	Yes	No	0	5	0	1
L:L:?1	R:R:F107	17.08	1	Yes	No	0	6	0	1
L:L:?1	R:R:R111	13.85	1	Yes	No	0	7	0	1
L:L:?1	R:R:I178	7.51	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:F180	13.88	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L280	12.13	1	Yes	No	0	5	0	1
L:L:?1	R:R:T283	5.17	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y284	8.22	1	Yes	Yes	0	7	0	1
R:R:F21	R:R:I178	3.77	9	No	Yes	3	3	2	1
R:R:L34	R:R:V83	4.47	3	Yes	No	8	6	2	1
R:R:E37	R:R:Y284	7.86	0	No	Yes	7	7	2	1
R:R:F107	R:R:L76	3.65	0	No	Yes	6	6	1	2
R:R:L76	R:R:Y284	4.69	1	Yes	Yes	6	7	2	1
R:R:L76	R:R:S287	3	1	Yes	No	6	8	2	2
R:R:L80	R:R:V83	4.47	0	No	No	8	6	2	1
R:R:R111	R:R:T283	9.06	1	No	No	7	8	1	1
R:R:I178	R:R:S181	4.64	0	Yes	No	3	5	1	2
R:R:F180	R:R:S179	3.96	0	Yes	No	4	5	1	2
R:R:F180	R:R:R251	3.21	0	Yes	Yes	4	6	1	2
R:R:F180	R:R:F276	8.57	0	Yes	No	4	4	1	2
R:R:F276	R:R:L280	13.4	0	No	No	4	5	2	1
R:R:T283	R:R:Y284	12.48	1	No	Yes	8	7	1	1
R:R:S287	R:R:Y284	6.36	1	No	Yes	8	7	2	1
R:R:F107	R:R:V103	2.62	0	No	No	6	5	1	2
R:R:I178	R:R:V176	1.54	0	Yes	No	3	1	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9JKX_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.83
Number of Linked Nodes	271
Number of Links	312
Number of Hubs	43
Number of Links mediated by Hubs	163
Number of Communities	13
Number of Nodes involved in Communities	73
Number of Links involved in Communities	93

Path Summary
Number Of Nodes in MetaPath	97
Number Of Links MetaPath	96
Number of Shortest Paths	42277
Length Of Smallest Path	3
Average Path Length	12.9809
Length of Longest Path	30
Minimum Path Strength	1.36
Average Path Strength	5.804
Maximum Path Strength	15.48
Minimum Path Correlation	0.7
Average Path Correlation	0.925581
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	51.179
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.2731
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	P9X
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	P9X
Name	(5~{S})-5-methyl-4-oxidanylidene-5-phenyl-furan-2-carboxylic acid
Synonyms	Acifran
Identifier
Formula	C12 H10 O4
Molecular Weight	218.205
SMILES
PubChem	76969700
Formal Charge	0
Total Atoms	26
Total Chiral Atoms	1
Total Bonds	27
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49019
Sequence	>9JKX_nogp_Chain_R N C C V F R D D F I A K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F V M D Y Y V R R S D W K F G D I P C R L V L F M F A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N W T A A I I S C L L W G I T V G L T V H L L K K K L L I Q N G T A N V C I S F S I C H T F R W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I H I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IHJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.07	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-		3.07	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHK	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-	-	3.21	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	9JKS	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 44250176	-	Gi1/β1/γ2	3.31	2025-10-29	To be published
	9JKS (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 44250176	-		3.31	2025-10-29	To be published
	9JKT	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	(2R)-2-hydroxy-3-phenylpropanoic acid	-	Gi1/β1/γ2	3.05	2025-10-29	To be published
	9JKT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	(2R)-2-hydroxy-3-phenylpropanoic acid	-		3.05	2025-10-29	To be published
	9JKV	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 2736690	-	Gi1/β1/γ2	3.26	2025-10-29	To be published
	9JKV (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 2736690	-		3.26	2025-10-29	To be published
	9JKX	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.18	2025-10-29	To be published
	9JKX (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-		3.18	2025-10-29	To be published
	8JEF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 11367166	-	Gi1/β1/γ2	2.96	2024-12-18	doi.org/10.1016/j.celrep.2024.114895
	8JEF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 11367166	-		2.96	2024-12-18	doi.org/10.1016/j.celrep.2024.114895
	9KT6	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.01	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT6 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-		3.01	2025-12-10	10.1021/acs.jmedchem.4c02567
	9JIC	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	-	-	Gi1/β1/γ2	3.4	2025-12-17	10.1016/j.celrep.2024.114895
	9JIC (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	-	-		3.4	2025-12-17	10.1016/j.celrep.2024.114895
	9JID	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.78	2025-12-17	10.1016/j.celrep.2024.114895
	9JID (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Niacin	-		2.78	2025-12-17	10.1016/j.celrep.2024.114895

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