psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:V83	12.95	Yes	No	1	0	6
2	L:L:?1	R:R:Y86	3.06	Yes	No	0	0	5
3	L:L:?1	R:R:Y87	9.17	Yes	No	1	0	5
4	L:L:?1	R:R:L104	6.02	Yes	Yes	1	0	5
5	L:L:?1	R:R:F107	28.59	Yes	No	1	0	6
6	L:L:?1	R:R:R111	9.5	Yes	No	0	0	7
7	L:L:?1	R:R:Y284	18.34	Yes	No	1	0	7
8	R:R:C18	R:R:N17	7.87	No	No	4	8	6
9	R:R:C183	R:R:N17	4.72	No	No	4	1	6
10	R:R:C18	R:R:S181	3.44	No	No	0	8	5
11	R:R:C18	R:R:C183	7.28	No	No	4	8	1
12	R:R:C19	R:R:F21	5.59	No	No	0	3	3
13	R:R:C19	R:R:C266	5.46	No	No	0	3	6
14	R:R:D273	R:R:F21	7.17	No	No	0	4	3
15	R:R:R22	R:R:S91	3.95	No	No	0	5	4
16	R:R:D23	R:R:I26	4.2	No	No	0	5	4
17	R:R:D24	R:R:F25	8.36	No	No	0	4	5
18	R:R:I26	R:R:L30	5.71	No	Yes	0	4	6
19	R:R:I26	R:R:Y87	3.63	No	No	0	4	5
20	R:R:L30	R:R:V29	4.47	Yes	No	0	6	4
21	R:R:I278	R:R:L30	5.71	No	Yes	0	5	6
22	R:R:L30	R:R:S281	4.5	Yes	No	0	6	5
23	R:R:P31	R:R:P32	5.84	No	No	0	6	4
24	R:R:E37	R:R:V33	7.13	No	No	0	7	6
25	R:R:L34	R:R:L80	9.69	No	No	0	8	8
26	R:R:L34	R:R:M84	7.07	No	No	0	8	7
27	R:R:G35	R:R:M84	3.49	No	No	0	5	7
28	R:R:F40	R:R:L36	4.87	No	No	0	5	4
29	R:R:F38	R:R:L42	3.65	No	No	0	6	6
30	R:R:F38	R:R:L80	9.74	No	No	0	6	8
31	R:R:F38	R:R:P81	7.22	No	No	0	6	9
32	R:R:F40	R:R:M288	6.22	No	Yes	0	5	6
33	R:R:F74	R:R:L42	7.31	Yes	No	0	7	6
34	R:R:G44	R:R:P291	4.06	No	Yes	0	7	9
35	R:R:D73	R:R:N45	12.12	Yes	Yes	2	9	9
36	R:R:F74	R:R:N45	12.08	Yes	Yes	0	7	9
37	R:R:I77	R:R:N45	5.66	Yes	Yes	2	5	9
38	R:R:N45	R:R:P291	6.52	Yes	Yes	2	9	9
39	R:R:I51	R:R:L47	2.85	Yes	No	0	7	5
40	R:R:F296	R:R:L47	7.31	No	No	0	7	5
41	R:R:F74	R:R:L49	4.87	Yes	No	0	7	7
42	R:R:F54	R:R:W50	19.04	No	No	0	4	4
43	R:R:H55	R:R:W50	4.23	No	No	0	5	4
44	R:R:H55	R:R:I51	9.28	No	Yes	0	5	7
45	R:R:F52	R:R:L56	12.18	No	No	0	7	6
46	R:R:F52	R:R:Y295	7.22	No	Yes	0	7	5
47	R:R:C53	R:R:F54	8.38	No	No	0	2	4
48	R:R:L56	R:R:W59	14.81	No	Yes	0	6	6
49	R:R:I64	R:R:W59	5.87	Yes	Yes	0	6	6
50	R:R:F67	R:R:W59	5.01	No	Yes	0	6	6
51	R:R:F65	R:R:S61	5.28	No	No	0	6	7
52	R:R:I139	R:R:S61	6.19	No	No	0	7	7
53	R:R:A144	R:R:S61	3.42	No	No	0	8	7
54	R:R:D124	R:R:S62	5.89	No	No	6	8	8
55	R:R:R128	R:R:S62	3.95	No	No	6	8	8
56	R:R:I64	R:R:N68	2.83	Yes	Yes	0	6	9
57	R:R:A144	R:R:I64	3.25	No	Yes	0	8	6
58	R:R:F65	R:R:V120	9.18	No	No	0	6	6
59	R:R:L66	R:R:Y294	3.52	No	Yes	2	8	9
60	R:R:L66	R:R:Y295	7.03	No	Yes	2	8	5
61	R:R:F67	R:R:N68	4.83	No	Yes	0	6	9
62	R:R:F67	R:R:V71	3.93	No	No	0	6	5
63	R:R:F117	R:R:N68	9.67	No	Yes	0	7	9
64	R:R:N68	R:R:S148	5.96	Yes	No	0	9	6
65	R:R:F117	R:R:L69	6.09	No	Yes	0	7	9
66	R:R:L118	R:R:L69	5.54	No	Yes	0	8	9
67	R:R:L69	R:R:Y295	4.69	Yes	Yes	0	9	5
68	R:R:A70	R:R:Y295	5.34	No	Yes	0	8	5
69	R:R:D73	R:R:I77	2.8	Yes	Yes	2	9	5
70	R:R:D73	R:R:S287	7.36	Yes	No	2	9	8
71	R:R:D73	R:R:P291	3.22	Yes	Yes	2	9	9
72	R:R:F74	R:R:I78	7.54	Yes	No	0	7	4
73	R:R:L75	R:R:N110	5.49	No	No	0	6	8
74	R:R:L76	R:R:N110	6.87	No	No	0	6	8
75	R:R:L76	R:R:S287	6.01	No	No	0	6	8
76	R:R:I77	R:R:S287	3.1	Yes	No	2	5	8
77	R:R:C79	R:R:M106	3.24	No	No	0	6	5
78	R:R:F82	R:R:F95	5.36	No	Yes	0	6	7
79	R:R:F82	R:R:V103	7.87	No	No	0	6	5
80	R:R:V83	R:R:Y87	5.05	No	No	1	6	5
81	R:R:F107	R:R:V83	5.24	No	No	1	6	6
82	R:R:D85	R:R:F95	7.17	No	Yes	0	4	7
83	R:R:W93	R:R:Y86	2.89	Yes	No	0	9	5
84	R:R:R89	R:R:V88	6.54	No	No	0	4	3
85	R:R:D92	R:R:R89	3.57	No	No	0	3	4
86	R:R:S91	R:R:T173	3.2	No	No	0	4	5
87	R:R:D92	R:R:T173	4.34	No	No	7	3	5
88	R:R:D92	R:R:N175	12.12	No	No	7	3	3
89	R:R:F95	R:R:W93	8.02	Yes	Yes	1	7	9
90	R:R:G96	R:R:W93	2.81	No	Yes	1	8	9
91	R:R:P99	R:R:W93	4.05	Yes	Yes	1	5	9
92	R:R:C100	R:R:W93	5.22	No	Yes	1	9	9
93	R:R:V103	R:R:W93	3.68	No	Yes	0	5	9
94	R:R:C177	R:R:W93	13.06	No	Yes	1	9	9
95	R:R:F95	R:R:P99	2.89	Yes	Yes	1	7	5
96	R:R:G96	R:R:P99	4.06	No	Yes	1	8	5
97	R:R:D97	R:R:I98	2.8	No	Yes	1	3	1
98	R:R:D97	R:R:K166	11.06	No	No	1	3	5
99	R:R:D97	R:R:L168	2.71	No	No	0	3	4
100	R:R:I98	R:R:P99	3.39	Yes	Yes	1	1	5
101	R:R:I98	R:R:R101	6.26	Yes	Yes	1	1	7
102	R:R:I98	R:R:K166	4.36	Yes	No	1	1	5
103	R:R:C100	R:R:L104	3.17	No	Yes	1	9	5
104	R:R:C100	R:R:C177	7.28	No	No	1	9	9
105	R:R:L102	R:R:R101	3.64	No	Yes	0	4	7
106	R:R:L163	R:R:R101	9.72	No	Yes	0	4	7
107	R:R:K166	R:R:R101	11.14	No	Yes	1	5	7
108	R:R:L104	R:R:V103	2.98	Yes	No	0	5	5
109	R:R:C177	R:R:L104	4.76	No	Yes	1	9	5
110	R:R:L104	R:R:S179	3	Yes	No	1	5	5
111	R:R:F105	R:R:M109	7.46	No	Yes	8	5	5
112	R:R:F105	R:R:T159	10.38	No	No	8	5	6
113	R:R:F105	R:R:L163	9.74	No	No	0	5	4
114	R:R:M106	R:R:M109	2.89	No	Yes	0	5	5
115	R:R:F107	R:R:Y284	7.22	No	No	1	6	7
116	R:R:A108	R:R:H189	2.93	No	Yes	0	5	5
117	R:R:M109	R:R:N110	5.61	Yes	No	0	5	8
118	R:R:M109	R:R:T159	10.54	Yes	No	8	5	6
119	R:R:E196	R:R:R111	11.63	Yes	No	0	6	7
120	R:R:F244	R:R:R111	3.21	Yes	No	0	9	7
121	R:R:Q112	R:R:T155	4.25	Yes	Yes	0	7	7
122	R:R:M192	R:R:Q112	8.16	No	Yes	0	5	7
123	R:R:E196	R:R:Q112	6.37	Yes	Yes	0	6	7
124	R:R:E196	R:R:I115	6.83	Yes	No	0	6	8
125	R:R:I115	R:R:P200	3.39	No	No	0	8	9
126	R:R:F244	R:R:I115	6.28	Yes	No	0	9	8
127	R:R:I116	R:R:L151	5.71	No	No	0	5	7
128	R:R:F117	R:R:W152	8.02	No	No	0	7	9
129	R:R:L118	R:R:Y294	8.21	No	Yes	0	8	9
130	R:R:P200	R:R:T119	3.5	No	No	0	9	7
131	R:R:I203	R:R:T119	4.56	No	No	0	6	7
132	R:R:I204	R:R:T119	3.04	No	No	0	8	7
133	R:R:R125	R:R:V121	5.23	Yes	No	2	9	8
134	R:R:V121	R:R:Y294	3.79	No	Yes	2	8	9
135	R:R:D124	R:R:R128	5.96	No	No	6	8	8
136	R:R:F232	R:R:R125	9.62	No	Yes	0	7	9
137	R:R:I233	R:R:R125	3.76	No	Yes	0	7	9
138	R:R:R125	R:R:Y294	4.12	Yes	Yes	2	9	9
139	R:R:F127	R:R:Y126	4.13	Yes	Yes	0	5	8
140	R:R:V130	R:R:Y126	11.36	No	Yes	0	7	8
141	R:R:F206	R:R:Y126	5.16	No	Yes	9	3	8
142	R:R:C207	R:R:Y126	9.41	No	Yes	0	6	8
143	R:R:R210	R:R:Y126	5.14	No	Yes	9	4	8
144	R:R:F127	R:R:H131	3.39	Yes	No	0	5	6
145	R:R:F127	R:R:H134	9.05	Yes	No	0	5	5
146	R:R:F127	R:R:L136	6.09	Yes	No	0	5	4
147	R:R:N137	R:R:R128	4.82	No	No	0	4	8
148	R:R:I211	R:R:V129	12.29	No	No	0	8	8
149	R:R:H131	R:R:V130	6.92	No	No	0	6	7
150	R:R:S214	R:R:V130	3.23	No	No	0	5	7
151	R:R:S140	R:R:T143	4.8	No	No	0	6	3
152	R:R:I146	R:R:W142	9.4	No	No	0	3	4
153	R:R:I147	R:R:L151	2.85	No	No	0	4	7
154	R:R:H161	R:R:L162	12.86	No	No	0	8	3
155	R:R:H161	R:R:W188	9.52	No	No	0	8	4
156	R:R:H189	R:R:L162	5.14	Yes	No	0	5	3
157	R:R:K165	R:R:L167	2.82	No	No	0	4	4
158	R:R:A174	R:R:Q170	6.06	No	No	0	3	2
159	R:R:G172	R:R:N171	3.39	No	No	0	3	2
160	R:R:N175	R:R:T173	5.85	No	No	7	3	5
161	R:R:I178	R:R:V176	3.07	No	Yes	0	3	1
162	R:R:F180	R:R:S179	3.96	Yes	No	1	4	5
163	R:R:H189	R:R:S179	5.58	Yes	No	1	5	5
164	R:R:F180	R:R:H189	7.92	Yes	Yes	1	4	5
165	R:R:F180	R:R:F193	10.72	Yes	Yes	1	4	5
166	R:R:F180	R:R:R251	3.21	Yes	Yes	1	4	6
167	R:R:F180	R:R:F276	7.5	Yes	Yes	1	4	4
168	R:R:I182	R:R:Y269	6.04	No	Yes	0	2	4
169	R:R:D273	R:R:I182	2.8	No	No	0	4	2
170	R:R:C183	R:R:R187	2.79	No	No	0	1	1
171	R:R:H184	R:R:T263	4.11	No	No	0	3	3
172	R:R:E190	R:R:R187	13.96	No	No	0	4	1
173	R:R:M192	R:R:W188	9.31	No	No	0	5	4
174	R:R:E190	R:R:R251	12.79	No	Yes	1	4	6
175	R:R:E190	R:R:F255	11.66	No	No	1	4	5
176	R:R:E196	R:R:F193	4.66	Yes	Yes	0	6	5
177	R:R:F193	R:R:S247	3.96	Yes	No	0	5	6
178	R:R:F193	R:R:R251	3.21	Yes	Yes	1	5	6
179	R:R:F193	R:R:F276	3.22	Yes	Yes	1	5	4
180	R:R:I252	R:R:L194	4.28	No	No	0	6	4
181	R:R:F197	R:R:F198	7.5	Yes	No	0	8	4
182	R:R:F197	R:R:L201	3.65	Yes	No	3	8	6
183	R:R:F197	R:R:F240	3.22	Yes	No	3	8	9
184	R:R:F197	R:R:F244	4.29	Yes	Yes	3	8	9
185	R:R:F197	R:R:V248	11.8	Yes	No	0	8	8
186	R:R:L199	R:R:P200	3.28	No	No	0	5	9
187	R:R:I203	R:R:L199	5.71	No	No	0	6	5
188	R:R:F240	R:R:L201	3.65	No	No	3	9	6
189	R:R:F206	R:R:R210	11.76	No	No	9	3	4
190	R:R:I233	R:R:S208	3.1	No	No	0	7	8
191	R:R:R210	R:R:W213	3	No	No	0	4	4
192	R:R:I212	R:R:I230	4.42	No	No	0	5	5
193	R:R:I212	R:R:I233	2.94	No	No	0	5	7
194	R:R:I212	R:R:M234	2.92	No	No	0	5	5
195	R:R:L215	R:R:M220	2.83	No	No	0	8	3
196	R:R:I226	R:R:L215	2.85	Yes	No	0	7	8
197	R:R:D221	R:R:R216	14.29	No	No	0	3	4
198	R:R:M220	R:R:R218	7.44	No	No	0	3	6
199	R:R:H223	R:R:R222	9.03	No	No	0	3	4
200	R:R:I226	R:R:I230	2.94	Yes	No	0	7	5
201	R:R:P299	R:R:R228	8.65	No	No	0	5	7
202	R:R:F232	R:R:V236	5.24	No	No	0	7	7
203	R:R:V236	R:R:Y294	8.83	No	Yes	0	7	9
204	R:R:L289	R:R:V239	2.98	No	No	0	7	7
205	R:R:F240	R:R:F244	3.22	No	Yes	3	9	9
206	R:R:C243	R:R:F244	2.79	No	Yes	3	8	9
207	R:R:C243	R:R:N286	6.3	No	No	3	8	9
208	R:R:F244	R:R:N286	6.04	Yes	No	3	9	9
209	R:R:L245	R:R:P246	3.28	No	No	0	5	9
210	R:R:L245	R:R:V249	2.98	No	No	0	5	5
211	R:R:P246	R:R:T279	6.99	No	No	0	9	6
212	R:R:S247	R:R:T279	3.2	No	No	0	6	6
213	R:R:S247	R:R:T283	4.8	No	No	0	6	8
214	R:R:F276	R:R:V250	5.24	Yes	No	0	4	4
215	R:R:I254	R:R:R251	7.52	No	Yes	0	5	6
216	R:R:F255	R:R:R251	4.28	No	Yes	1	5	6
217	R:R:F276	R:R:R251	13.9	Yes	Yes	1	4	6
218	R:R:H253	R:R:W256	4.23	No	No	0	5	4
219	R:R:I254	R:R:V272	3.07	No	No	0	5	4
220	R:R:T260	R:R:W256	10.92	No	No	0	1	4
221	R:R:L257	R:R:V268	4.47	No	No	0	2	1
222	R:R:L258	R:R:T263	4.42	No	No	10	3	3
223	R:R:L258	R:R:Y269	5.86	No	Yes	10	3	4
224	R:R:G262	R:R:S261	3.71	No	No	0	3	4
225	R:R:T263	R:R:Y269	4.99	No	Yes	10	3	4
226	R:R:E267	R:R:N265	9.2	No	No	0	1	4
227	R:R:V268	R:R:Y269	10.09	No	Yes	0	1	4
228	R:R:L274	R:R:S271	3	No	No	0	3	2
229	R:R:D273	R:R:F277	10.75	No	No	0	4	5
230	R:R:F276	R:R:L280	7.31	Yes	No	0	4	5
231	R:R:M285	R:R:M288	4.33	No	Yes	5	5	6
232	R:R:L289	R:R:M285	8.48	No	No	5	7	5
233	R:R:D290	R:R:N286	10.77	No	No	0	9	9
234	R:R:L289	R:R:M288	2.83	No	Yes	5	7	6
235	R:R:P291	R:R:Y295	2.78	Yes	Yes	2	9	5
236	R:R:Y294	R:R:Y295	5.96	Yes	Yes	2	9	5
237	R:R:P299	R:R:S298	3.56	No	No	0	5	8
238	R:R:S298	R:R:S300	4.89	No	No	0	8	6
239	R:R:D23	R:R:D24	2.66	No	No	0	5	4
240	R:R:L158	R:R:Q112	2.66	No	Yes	0	4	7
241	R:R:F301	R:R:S298	2.64	No	No	0	8	8
242	R:R:F127	R:R:V123	2.62	Yes	No	0	5	6
243	R:R:F232	R:R:V293	2.62	No	No	0	7	7
244	R:R:F296	R:R:V292	2.62	No	No	0	7	6
245	R:R:A72	R:R:W152	2.59	No	No	0	8	9
246	R:R:A191	R:R:W188	2.59	No	No	0	2	4
247	R:R:H259	R:R:L258	2.57	No	No	0	2	3
248	R:R:S91	R:R:Y86	2.54	No	No	0	4	5
249	R:R:F52	R:R:I51	2.51	No	Yes	0	7	7
250	R:R:F301	R:R:I51	2.51	No	Yes	0	8	7
251	R:R:F65	R:R:I147	2.51	No	No	0	6	4
252	R:R:F277	R:R:I178	2.51	No	No	0	5	3
253	R:R:F282	R:R:I278	2.51	No	No	0	7	5
254	R:R:K94	R:R:R89	2.48	No	No	0	3	4
255	R:R:F277	R:R:L280	2.44	No	No	0	5	5
256	R:R:I211	R:R:Y126	2.42	No	Yes	0	8	8
257	R:R:E267	R:R:R270	2.33	No	No	0	1	2
258	R:R:E37	R:R:Y284	2.24	No	No	0	7	7
259	R:R:G153	R:R:V156	1.84	No	No	0	4	4
260	R:R:G157	R:R:V160	1.84	No	No	0	4	4
261	R:R:G172	R:R:V176	1.84	No	Yes	0	3	1
262	R:R:G113	R:R:T155	1.82	No	Yes	0	6	7
263	R:R:G41	R:R:I77	1.76	No	Yes	0	8	5
264	R:R:G41	R:R:M288	1.75	No	Yes	0	8	6
265	R:R:G44	R:R:L43	1.71	No	No	0	7	4
266	R:R:G202	R:R:L201	1.71	No	No	0	3	6
267	R:R:G202	R:R:L205	1.71	No	No	0	3	4
268	R:R:M84	R:R:P31	1.68	No	No	0	7	6
269	R:R:K225	R:R:P299	1.67	No	No	0	5	5
270	R:R:C207	R:R:I203	1.64	No	No	0	6	6
271	R:R:A122	R:R:I204	1.62	No	No	0	9	8
272	R:R:A237	R:R:I204	1.62	No	No	0	7	8
273	R:R:S271	R:R:V272	1.62	No	No	0	2	4
274	R:R:V176	R:R:V20	1.6	Yes	No	0	1	2
275	R:R:V235	R:R:V239	1.6	No	No	0	5	7
276	R:R:V235	R:R:V293	1.6	No	No	0	5	7
277	R:R:T155	R:R:V156	1.59	Yes	No	0	7	4
278	R:R:A275	R:R:L274	1.58	No	No	0	5	3
279	R:R:I169	R:R:V176	1.54	No	Yes	0	1	1
280	R:R:I252	R:R:V248	1.54	No	No	0	6	8
281	R:R:H131	R:R:P132	1.53	No	No	0	6	8
282	R:R:H133	R:R:P132	1.53	No	No	0	5	8
283	R:R:I139	R:R:T143	1.52	No	No	0	7	3
284	R:R:I154	R:R:T155	1.52	No	Yes	0	4	7
285	R:R:L69	R:R:S114	1.5	Yes	No	0	9	9
286	R:R:L257	R:R:S261	1.5	No	No	0	2	4
287	R:R:L163	R:R:V160	1.49	No	No	0	4	4
288	R:R:L245	R:R:V241	1.49	No	No	0	5	4
289	R:R:N265	R:R:V268	1.48	No	No	0	4	1
290	R:R:I238	R:R:I242	1.47	No	No	0	4	5
291	R:R:A135	R:R:H134	1.46	No	No	0	5	5
292	R:R:I238	R:R:M234	1.46	No	No	0	4	5
293	R:R:I39	R:R:L43	1.43	No	No	0	5	4
294	R:R:I147	R:R:L150	1.43	No	No	0	4	3
295	R:R:I169	R:R:L167	1.43	No	No	0	1	4
296	R:R:I64	R:R:N141	1.42	Yes	No	0	6	3
297	R:R:D221	R:R:I226	1.4	No	Yes	0	3	7
298	R:R:A48	R:R:F296	1.39	No	No	0	8	7
299	R:R:A27	R:R:R90	1.38	No	No	0	4	3
300	R:R:H184	R:R:T185	1.37	No	No	0	3	4
301	R:R:L168	R:R:Q170	1.33	No	No	0	4	2
302	R:R:H223	R:R:I226	1.33	No	Yes	0	3	7
303	R:R:R63	R:R:S58	1.32	No	No	0	7	6
304	R:R:N265	R:R:Q264	1.32	No	No	0	4	1
305	R:R:D221	R:R:Q219	1.31	No	No	0	3	4
306	R:R:F186	R:R:T185	1.3	No	No	0	3	4
307	R:R:H134	R:R:N137	1.28	No	No	0	5	4
308	R:R:K60	R:R:R63	1.24	No	No	0	7	7
309	R:R:S140	R:R:W142	1.24	No	No	0	6	4
310	R:R:R63	R:R:W59	1	No	Yes	0	7	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	12.5186	7	1	0
2	R:R:L30	5.0975	4	0	6
3	R:R:N45	9.095	4	2	9
4	R:R:I51	4.2875	4	0	7
5	R:R:W59	6.6725	4	0	6
6	R:R:I64	3.3425	4	0	6
7	R:R:N68	5.8225	4	0	9
8	R:R:L69	4.455	4	0	9
9	R:R:D73	6.375	4	2	9
10	R:R:F74	7.95	4	0	7
11	R:R:I77	3.33	4	2	5
12	R:R:W93	5.67571	7	1	9
13	R:R:F95	5.86	4	1	7
14	R:R:I98	4.2025	4	1	1
15	R:R:P99	3.5975	4	1	5
16	R:R:R101	7.69	4	1	7
17	R:R:L104	3.986	5	1	5
18	R:R:M109	6.625	4	8	5
19	R:R:Q112	5.36	4	0	7
20	R:R:R125	5.6825	4	2	9
21	R:R:Y126	6.27	6	9	8
22	R:R:F127	5.056	5	0	5
23	R:R:T155	2.295	4	0	7
24	R:R:V176	2.0125	4	0	1
25	R:R:F180	6.662	5	1	4
26	R:R:H189	5.3925	4	1	5
27	R:R:F193	5.154	5	1	5
28	R:R:E196	7.3725	4	0	6
29	R:R:F197	6.092	5	3	8
30	R:R:I226	2.13	4	0	7
31	R:R:F244	4.305	6	3	9
32	R:R:R251	7.485	6	1	6
33	R:R:Y269	6.745	4	10	4
34	R:R:F276	7.434	5	1	4
35	R:R:M288	3.7825	4	5	6
36	R:R:P291	4.145	4	2	9
37	R:R:Y294	5.73833	6	2	9
38	R:R:Y295	5.50333	6	2	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L104	R:R:S179	53.7954	3	Yes	No	1	5	5
2	R:R:F180	R:R:S179	47.8835	3.96	Yes	No	1	4	5
3	R:R:F180	R:R:R251	11.4956	3.21	Yes	Yes	1	4	6
4	L:L:?1	R:R:R111	52.1632	9.5	Yes	No	0	0	7
5	R:R:E196	R:R:R111	29.5146	11.63	Yes	No	0	6	7
6	R:R:E196	R:R:F193	14.9376	4.66	Yes	Yes	0	6	5
7	R:R:F180	R:R:F276	29.0052	7.5	Yes	Yes	1	4	4
8	R:R:F276	R:R:L280	35.2364	7.31	Yes	No	0	4	5
9	R:R:F277	R:R:L280	34.1046	2.44	No	No	0	5	5
10	R:R:D273	R:R:F277	23.7911	10.75	No	No	0	4	5
11	L:L:?1	R:R:Y86	50.8233	3.06	Yes	No	0	0	5
12	R:R:W93	R:R:Y86	49.2449	2.89	Yes	No	0	9	5
13	R:R:P99	R:R:W93	99.2915	4.05	Yes	Yes	1	5	9
14	R:R:I98	R:R:P99	100	3.39	Yes	Yes	1	1	5
15	R:R:I98	R:R:R101	97.3275	6.26	Yes	Yes	1	1	7
16	R:R:L163	R:R:R101	97.7902	9.72	No	Yes	0	4	7
17	R:R:F105	R:R:L163	96.4934	9.74	No	No	0	5	4
18	R:R:F105	R:R:M109	95.3616	7.46	No	Yes	8	5	5
19	R:R:M109	R:R:N110	94.2603	5.61	Yes	No	0	5	8
20	R:R:L76	R:R:N110	93.3419	6.87	No	No	0	6	8
21	R:R:L76	R:R:S287	92.8774	6.01	No	No	0	6	8
22	R:R:D73	R:R:S287	76.1551	7.36	Yes	No	2	9	8
23	R:R:F74	R:R:N45	19.2406	12.08	Yes	Yes	0	7	9
24	R:R:F74	R:R:L42	14.4784	7.31	Yes	No	0	7	6
25	R:R:F38	R:R:L42	12.8838	3.65	No	No	0	6	6
26	R:R:I77	R:R:S287	16.2523	3.1	Yes	No	2	5	8
27	R:R:I77	R:R:N45	10.3781	5.66	Yes	Yes	2	5	9
28	R:R:D73	R:R:P291	67.4146	3.22	Yes	Yes	2	9	9
29	R:R:P291	R:R:Y295	68.22	2.78	Yes	Yes	2	9	5
30	R:R:F52	R:R:Y295	31.0052	7.22	No	Yes	0	7	5
31	R:R:F52	R:R:I51	12.9897	2.51	No	Yes	0	7	7
32	R:R:F52	R:R:L56	18.6899	12.18	No	No	0	7	6
33	R:R:L56	R:R:W59	17.8846	14.81	No	Yes	0	6	6
34	R:R:I64	R:R:W59	12.9359	5.87	Yes	Yes	0	6	6
35	R:R:L69	R:R:Y295	20.5912	4.69	Yes	Yes	0	9	5
36	R:R:F117	R:R:L69	19.3536	6.09	No	Yes	0	7	9
37	R:R:F117	R:R:N68	16.8837	9.67	No	Yes	0	7	9
38	R:R:I64	R:R:N68	13.4399	2.83	Yes	Yes	0	6	9
39	R:R:A144	R:R:I64	22.679	3.25	No	Yes	0	8	6
40	R:R:A144	R:R:S61	20.9481	3.42	No	No	0	8	7
41	R:R:F65	R:R:S61	10.4821	5.28	No	No	0	6	7
42	R:R:E196	R:R:I115	28.2124	6.83	Yes	No	0	6	8
43	R:R:I115	R:R:P200	46.2889	3.39	No	No	0	8	9
44	R:R:P200	R:R:T119	24.0332	3.5	No	No	0	9	7
45	R:R:I203	R:R:T119	20.8836	4.56	No	No	0	6	7
46	R:R:C207	R:R:I203	39.9896	1.64	No	No	0	6	6
47	R:R:C207	R:R:Y126	38.3556	9.41	No	Yes	0	6	8
48	R:R:F127	R:R:Y126	20.1302	4.13	Yes	Yes	0	5	8
49	R:R:F127	R:R:H134	10.075	9.05	Yes	No	0	5	5
50	R:R:F244	R:R:R111	26.6376	3.21	Yes	No	0	9	7
51	R:R:F244	R:R:I115	22.7633	6.28	Yes	No	0	9	8
52	R:R:L199	R:R:P200	21.5364	3.28	No	No	0	5	9
53	R:R:I203	R:R:L199	20.749	5.71	No	No	0	6	5
54	R:R:Y294	R:R:Y295	21.3678	5.96	Yes	Yes	2	9	5
55	R:R:L104	R:R:V103	18.1967	2.98	Yes	No	0	5	5
56	R:R:C100	R:R:L104	17.5994	3.17	No	Yes	1	9	5
57	R:R:C177	R:R:L104	17.5563	4.76	No	Yes	1	9	5
58	R:R:D273	R:R:I182	19.2172	2.8	No	No	0	4	2
59	R:R:I182	R:R:Y269	18.1572	6.04	No	Yes	0	2	4
60	R:R:F193	R:R:S247	10.2059	3.96	Yes	No	0	5	6
61	R:R:R125	R:R:Y294	17.2532	4.12	Yes	Yes	2	9	9
62	R:R:I233	R:R:R125	14.6811	3.76	No	Yes	0	7	9
63	R:R:I212	R:R:I233	13.0237	2.94	No	No	0	5	7
64	R:R:V103	R:R:W93	17.5097	3.68	No	Yes	0	5	9
65	R:R:C100	R:R:W93	17.5079	5.22	No	Yes	1	9	9
66	R:R:C177	R:R:W93	17.5079	13.06	No	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:V83	12.95	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y86	3.06	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y87	9.17	1	Yes	No	0	5	0	1
L:L:?1	R:R:L104	6.02	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F107	28.59	1	Yes	No	0	6	0	1
L:L:?1	R:R:R111	9.5	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y284	18.34	1	Yes	No	0	7	0	1
R:R:I26	R:R:Y87	3.63	0	No	No	4	5	2	1
R:R:V83	R:R:Y87	5.05	1	No	No	6	5	1	1
R:R:F107	R:R:V83	5.24	1	No	No	6	6	1	1
R:R:W93	R:R:Y86	2.89	1	Yes	No	9	5	2	1
R:R:C100	R:R:W93	5.22	1	No	Yes	9	9	2	2
R:R:V103	R:R:W93	3.68	0	No	Yes	5	9	2	2
R:R:C177	R:R:W93	13.06	1	No	Yes	9	9	2	2
R:R:C100	R:R:L104	3.17	1	No	Yes	9	5	2	1
R:R:C100	R:R:C177	7.28	1	No	No	9	9	2	2
R:R:L104	R:R:V103	2.98	1	Yes	No	5	5	1	2
R:R:C177	R:R:L104	4.76	1	No	Yes	9	5	2	1
R:R:L104	R:R:S179	3	1	Yes	No	5	5	1	2
R:R:F107	R:R:Y284	7.22	1	No	No	6	7	1	1
R:R:E196	R:R:R111	11.63	0	Yes	No	6	7	2	1
R:R:F244	R:R:R111	3.21	3	Yes	No	9	7	2	1
R:R:S91	R:R:Y86	2.54	0	No	No	4	5	2	1
R:R:E37	R:R:Y284	2.24	0	No	No	7	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9JKT_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.71
Number of Linked Nodes	271
Number of Links	310
Number of Hubs	38
Number of Links mediated by Hubs	144
Number of Communities	10
Number of Nodes involved in Communities	61
Number of Links involved in Communities	80

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	85859
Length Of Smallest Path	3
Average Path Length	20.1245
Length of Longest Path	39
Minimum Path Strength	1.12
Average Path Strength	5.61864
Maximum Path Strength	17.305
Minimum Path Correlation	0.7
Average Path Correlation	0.921536
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	35.5489
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.044
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HF2
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	HF2
Name	(2R)-2-hydroxy-3-phenylpropanoic acid
Synonyms
Identifier
Formula	C9 H10 O3
Molecular Weight	166.174
SMILES
PubChem	643327
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	1
Total Bonds	22
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49019
Sequence	>9JKT_nogp_Chain_R N C C V F R D D F I A K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F V M D Y Y V R R S D W K F G D I P C R L V L F M F A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N W T A A I I S C L L W G I T V G L T V H L L K K K L L I Q N G T A N V C I S F S I C H T F R W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I H I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IHJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.07	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-		3.07	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHK	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-	-	3.21	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	9JKS	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 44250176	-	Gi1/β1/γ2	3.31	2025-10-29	To be published
	9JKS (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 44250176	-		3.31	2025-10-29	To be published
	9JKT	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	(2R)-2-hydroxy-3-phenylpropanoic acid	-	Gi1/β1/γ2	3.05	2025-10-29	To be published
	9JKT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	(2R)-2-hydroxy-3-phenylpropanoic acid	-		3.05	2025-10-29	To be published
	9JKV	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 2736690	-	Gi1/β1/γ2	3.26	2025-10-29	To be published
	9JKV (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 2736690	-		3.26	2025-10-29	To be published
	9JKX	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.18	2025-10-29	To be published
	9JKX (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-		3.18	2025-10-29	To be published
	8JEF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 11367166	-	Gi1/β1/γ2	2.96	2024-12-18	doi.org/10.1016/j.celrep.2024.114895
	8JEF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 11367166	-		2.96	2024-12-18	doi.org/10.1016/j.celrep.2024.114895
	9KT6	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.01	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT6 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-		3.01	2025-12-10	10.1021/acs.jmedchem.4c02567
	9JIC	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	-	-	Gi1/β1/γ2	3.4	2025-12-17	10.1016/j.celrep.2024.114895
	9JIC (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	-	-		3.4	2025-12-17	10.1016/j.celrep.2024.114895
	9JID	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.78	2025-12-17	10.1016/j.celrep.2024.114895
	9JID (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Niacin	-		2.78	2025-12-17	10.1016/j.celrep.2024.114895

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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