psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:V83	17.58	Yes	No	0	0	6
2	L:L:?1	R:R:W93	13.44	Yes	Yes	0	0	9
3	L:L:?1	R:R:L104	7.26	Yes	No	0	0	5
4	L:L:?1	R:R:F107	23.96	Yes	Yes	1	0	6
5	L:L:?1	R:R:Y284	9.23	Yes	Yes	1	0	7
6	R:R:C18	R:R:I182	9.82	No	No	0	8	2
7	R:R:C18	R:R:C183	7.28	No	No	0	8	1
8	R:R:C19	R:R:C266	7.28	No	No	0	3	6
9	R:R:F21	R:R:V20	6.55	No	No	0	3	2
10	R:R:F21	R:R:I178	7.54	No	No	0	3	3
11	R:R:F21	R:R:F277	4.29	No	Yes	0	3	5
12	R:R:R22	R:R:R270	4.26	No	Yes	0	5	2
13	R:R:D23	R:R:R270	11.91	No	Yes	3	5	2
14	R:R:D23	R:R:L274	5.43	No	No	3	5	3
15	R:R:A27	R:R:D24	6.18	No	No	0	4	4
16	R:R:F25	R:R:V29	3.93	No	No	0	5	4
17	R:R:K28	R:R:R89	17.33	No	No	0	3	4
18	R:R:K28	R:R:R90	14.85	No	No	0	3	3
19	R:R:L30	R:R:V33	4.47	Yes	No	0	6	6
20	R:R:P31	R:R:P32	5.84	No	No	0	6	4
21	R:R:E37	R:R:V33	5.7	Yes	No	0	7	6
22	R:R:E37	R:R:M285	5.41	Yes	No	0	7	5
23	R:R:E37	R:R:M288	12.18	Yes	No	0	7	6
24	R:R:F38	R:R:L80	4.87	Yes	No	0	6	8
25	R:R:F107	R:R:F38	4.29	Yes	Yes	1	6	6
26	R:R:F38	R:R:Y284	6.19	Yes	Yes	1	6	7
27	R:R:F38	R:R:S287	6.61	Yes	No	0	6	8
28	R:R:I77	R:R:L42	7.14	Yes	No	0	5	6
29	R:R:L43	R:R:L47	4.15	No	No	0	4	5
30	R:R:G44	R:R:L47	5.13	No	No	0	7	5
31	R:R:G44	R:R:P291	4.06	No	No	0	7	9
32	R:R:A70	R:R:N45	4.69	No	No	0	8	9
33	R:R:D73	R:R:N45	10.77	Yes	No	0	9	9
34	R:R:F74	R:R:N45	13.29	No	No	0	7	9
35	R:R:L47	R:R:W50	6.83	No	No	0	5	4
36	R:R:A48	R:R:Y294	8.01	No	Yes	0	8	9
37	R:R:F52	R:R:L49	4.87	No	No	0	7	7
38	R:R:F54	R:R:W50	13.03	No	No	0	4	4
39	R:R:H55	R:R:I51	7.95	No	No	0	5	7
40	R:R:I51	R:R:W59	5.87	No	Yes	0	7	6
41	R:R:F67	R:R:I51	3.77	No	No	0	6	7
42	R:R:F52	R:R:W59	7.02	No	Yes	0	7	6
43	R:R:F52	R:R:F67	5.36	No	No	0	7	6
44	R:R:C53	R:R:F54	8.38	No	No	0	2	4
45	R:R:H55	R:R:R63	11.28	No	No	0	5	7
46	R:R:L56	R:R:W59	5.69	No	Yes	0	6	6
47	R:R:I64	R:R:W59	8.22	No	Yes	0	6	6
48	R:R:I139	R:R:S61	6.19	No	No	0	7	7
49	R:R:R63	R:R:S298	6.59	No	No	0	7	8
50	R:R:I64	R:R:N141	7.08	No	No	0	6	3
51	R:R:A144	R:R:I64	4.87	No	No	0	8	6
52	R:R:F65	R:R:V120	9.18	No	No	0	6	6
53	R:R:D124	R:R:F65	4.78	No	No	0	8	6
54	R:R:L66	R:R:Y294	9.38	No	Yes	0	8	9
55	R:R:F67	R:R:V71	5.24	No	No	0	6	5
56	R:R:F117	R:R:N68	15.71	No	No	4	7	9
57	R:R:N68	R:R:S148	10.43	No	No	0	9	6
58	R:R:N68	R:R:W152	6.78	No	Yes	4	9	9
59	R:R:D290	R:R:L69	5.43	Yes	No	0	9	9
60	R:R:A70	R:R:Y294	4	No	Yes	0	8	9
61	R:R:V71	R:R:W152	4.9	No	Yes	0	5	9
62	R:R:A72	R:R:W152	3.89	No	Yes	0	8	9
63	R:R:D73	R:R:I77	8.4	Yes	Yes	0	9	5
64	R:R:D73	R:R:S287	4.42	Yes	No	0	9	8
65	R:R:D290	R:R:D73	13.31	Yes	Yes	0	9	9
66	R:R:F74	R:R:I77	8.79	No	Yes	0	7	5
67	R:R:L75	R:R:M106	4.24	No	No	0	6	5
68	R:R:F107	R:R:L76	20.7	Yes	No	0	6	6
69	R:R:L76	R:R:N110	21.97	No	No	0	6	8
70	R:R:C79	R:R:V103	5.12	Yes	No	0	6	5
71	R:R:C79	R:R:M106	6.48	Yes	No	0	6	5
72	R:R:C79	R:R:F107	5.59	Yes	Yes	0	6	6
73	R:R:L80	R:R:P81	4.93	No	No	0	8	9
74	R:R:D92	R:R:Y87	10.34	No	No	0	3	5
75	R:R:K94	R:R:Y87	7.17	No	No	0	3	5
76	R:R:V88	R:R:W93	9.81	No	Yes	0	3	9
77	R:R:D92	R:R:R89	5.96	No	No	0	3	4
78	R:R:N175	R:R:W93	6.78	No	Yes	0	3	9
79	R:R:C177	R:R:W93	3.92	No	Yes	0	9	9
80	R:R:G96	R:R:P99	6.09	No	No	0	8	5
81	R:R:C100	R:R:G96	3.92	No	No	0	9	8
82	R:R:D97	R:R:N171	9.42	No	No	0	3	2
83	R:R:I98	R:R:N171	8.5	No	No	0	1	2
84	R:R:C100	R:R:C177	7.28	No	No	0	9	9
85	R:R:L104	R:R:R101	3.64	No	No	0	5	7
86	R:R:L163	R:R:R101	6.07	No	No	0	4	7
87	R:R:F105	R:R:T159	3.89	No	Yes	0	5	6
88	R:R:F105	R:R:L163	4.87	No	No	0	5	4
89	R:R:F107	R:R:Y284	14.44	Yes	Yes	1	6	7
90	R:R:M109	R:R:T155	6.02	No	Yes	0	5	7
91	R:R:M109	R:R:T159	6.02	No	Yes	0	5	6
92	R:R:F193	R:R:R111	4.28	No	No	0	5	7
93	R:R:F244	R:R:R111	4.28	Yes	No	0	9	7
94	R:R:Q112	R:R:T155	4.25	No	Yes	0	7	7
95	R:R:L158	R:R:Q112	3.99	No	No	0	4	7
96	R:R:N286	R:R:S114	7.45	No	No	0	9	9
97	R:R:F240	R:R:I115	5.02	Yes	No	0	9	8
98	R:R:F244	R:R:I115	12.56	Yes	No	0	9	8
99	R:R:I116	R:R:L151	4.28	No	No	0	5	7
100	R:R:I116	R:R:T155	4.56	No	Yes	0	5	7
101	R:R:F117	R:R:W152	13.03	No	Yes	4	7	9
102	R:R:F240	R:R:L118	3.65	Yes	No	0	9	8
103	R:R:P200	R:R:T119	5.25	No	No	0	9	7
104	R:R:I203	R:R:T119	4.56	No	No	0	6	7
105	R:R:I204	R:R:T119	6.08	No	No	0	8	7
106	R:R:L151	R:R:V120	4.47	No	No	0	7	6
107	R:R:A122	R:R:I204	4.87	No	No	0	9	8
108	R:R:D124	R:R:R128	10.72	No	No	0	8	8
109	R:R:F232	R:R:R125	21.38	Yes	No	0	7	9
110	R:R:F127	R:R:Y126	5.16	No	Yes	0	5	8
111	R:R:V130	R:R:Y126	13.88	No	Yes	5	7	8
112	R:R:H131	R:R:Y126	7.62	No	Yes	5	6	8
113	R:R:C207	R:R:Y126	6.72	No	Yes	0	6	8
114	R:R:R210	R:R:Y126	8.23	No	Yes	0	4	8
115	R:R:F127	R:R:H134	9.05	No	No	0	5	5
116	R:R:F127	R:R:L136	9.74	No	No	0	5	4
117	R:R:N137	R:R:R128	6.03	No	No	0	4	8
118	R:R:I211	R:R:V129	6.14	No	No	0	8	8
119	R:R:H131	R:R:V130	6.92	No	No	5	6	7
120	R:R:H133	R:R:P132	4.58	No	No	0	5	8
121	R:R:H134	R:R:N137	3.83	No	No	0	5	4
122	R:R:I139	R:R:T143	9.12	No	No	0	7	3
123	R:R:I146	R:R:W142	19.97	No	No	0	3	4
124	R:R:I147	R:R:L150	4.28	No	No	0	4	3
125	R:R:I154	R:R:L150	5.71	No	No	0	4	3
126	R:R:T155	R:R:W152	4.85	Yes	Yes	0	7	9
127	R:R:E196	R:R:L158	7.95	No	No	0	6	4
128	R:R:H189	R:R:L162	3.86	No	No	0	5	3
129	R:R:F193	R:R:L162	14.61	No	No	0	5	3
130	R:R:S179	R:R:T173	6.4	No	No	0	5	5
131	R:R:N175	R:R:V176	5.91	No	No	0	3	1
132	R:R:I178	R:R:N175	7.08	No	No	0	3	3
133	R:R:C177	R:R:V176	6.83	No	No	0	9	1
134	R:R:F180	R:R:S181	5.28	No	No	0	4	5
135	R:R:F180	R:R:F276	8.57	No	Yes	0	4	4
136	R:R:R251	R:R:S181	7.91	No	No	0	6	5
137	R:R:D273	R:R:I182	7	No	No	0	4	2
138	R:R:H184	R:R:L258	15.43	No	No	0	3	3
139	R:R:F186	R:R:W188	8.02	No	No	7	3	4
140	R:R:F186	R:R:F255	6.43	No	No	7	3	5
141	R:R:F186	R:R:L258	21.92	No	No	0	3	3
142	R:R:F255	R:R:W188	9.02	No	No	7	5	4
143	R:R:E190	R:R:R251	6.98	No	No	0	4	6
144	R:R:E190	R:R:F255	23.32	No	No	0	4	5
145	R:R:L194	R:R:V248	5.96	No	No	0	4	8
146	R:R:L194	R:R:R251	3.64	No	No	0	4	6
147	R:R:I252	R:R:L194	7.14	No	No	0	6	4
148	R:R:F197	R:R:F198	9.65	Yes	No	2	8	4
149	R:R:F197	R:R:L201	4.87	Yes	Yes	2	8	6
150	R:R:F197	R:R:F240	4.29	Yes	Yes	2	8	9
151	R:R:F197	R:R:V248	18.35	Yes	No	2	8	8
152	R:R:F198	R:R:V248	3.93	No	No	2	4	8
153	R:R:L199	R:R:P200	4.93	No	No	0	5	9
154	R:R:I203	R:R:L199	4.28	No	No	0	6	5
155	R:R:L201	R:R:L205	8.3	Yes	No	0	6	4
156	R:R:F240	R:R:L201	7.31	Yes	Yes	2	9	6
157	R:R:F240	R:R:I204	5.02	Yes	No	0	9	8
158	R:R:F206	R:R:R210	5.34	No	No	0	3	4
159	R:R:I233	R:R:S208	7.74	No	No	0	7	8
160	R:R:I212	R:R:I230	7.36	No	No	0	5	5
161	R:R:S214	R:R:W213	7.41	No	No	0	5	4
162	R:R:Q217	R:R:W213	4.38	No	No	8	5	4
163	R:R:R218	R:R:W213	9	No	No	8	6	4
164	R:R:I226	R:R:L215	5.71	No	No	0	7	8
165	R:R:Q217	R:R:R218	4.67	No	No	8	5	6
166	R:R:D221	R:R:Q219	9.14	No	No	0	3	4
167	R:R:D221	R:R:I226	7	No	No	0	3	7
168	R:R:H223	R:R:K225	3.93	No	No	0	3	5
169	R:R:F232	R:R:I233	3.77	Yes	No	0	7	7
170	R:R:F232	R:R:V236	5.24	Yes	No	0	7	7
171	R:R:F232	R:R:V293	3.93	Yes	No	0	7	7
172	R:R:F232	R:R:S297	10.57	Yes	No	0	7	6
173	R:R:L289	R:R:V239	4.47	No	No	0	7	7
174	R:R:C243	R:R:F244	4.19	No	Yes	0	8	9
175	R:R:F244	R:R:N286	7.25	Yes	No	0	9	9
176	R:R:P246	R:R:T279	5.25	No	No	0	9	6
177	R:R:S247	R:R:T283	4.8	No	No	0	6	8
178	R:R:F276	R:R:V250	3.93	Yes	No	6	4	4
179	R:R:T279	R:R:V250	4.76	No	No	6	6	4
180	R:R:H253	R:R:W256	5.29	No	No	9	5	4
181	R:R:H253	R:R:L257	11.57	No	Yes	9	5	2
182	R:R:L257	R:R:W256	5.69	Yes	No	9	2	4
183	R:R:T260	R:R:W256	18.19	No	No	0	1	4
184	R:R:L257	R:R:Y269	4.69	Yes	No	0	2	4
185	R:R:N265	R:R:V268	7.39	No	No	0	4	1
186	R:R:E267	R:R:R270	4.65	No	Yes	0	1	2
187	R:R:L274	R:R:R270	10.93	No	Yes	3	3	2
188	R:R:F276	R:R:F277	7.5	Yes	Yes	0	4	5
189	R:R:F276	R:R:T279	3.89	Yes	No	6	4	6
190	R:R:L280	R:R:T283	5.9	No	No	1	5	8
191	R:R:L280	R:R:Y284	8.21	No	Yes	1	5	7
192	R:R:F282	R:R:M285	6.22	No	No	0	7	5
193	R:R:T283	R:R:Y284	4.99	No	Yes	1	8	7
194	R:R:L289	R:R:M285	5.65	No	No	0	7	5
195	R:R:D290	R:R:P291	12.88	Yes	No	0	9	9
196	R:R:D290	R:R:Y294	6.9	Yes	Yes	0	9	9
197	R:R:F296	R:R:V292	5.24	No	No	0	7	6
198	R:R:P299	R:R:S298	5.34	No	No	0	5	8
199	R:R:I211	R:R:Y126	3.63	No	Yes	0	8	8
200	R:R:D24	R:R:R90	3.57	No	No	0	4	3
201	R:R:N265	R:R:Y269	3.49	No	No	0	4	4
202	R:R:G35	R:R:L34	3.42	No	No	0	5	8
203	R:R:A144	R:R:S61	3.42	No	No	0	8	7
204	R:R:C207	R:R:V123	3.42	No	No	0	6	6
205	R:R:I98	R:R:P99	3.39	No	No	0	1	5
206	R:R:L30	R:R:P31	3.28	Yes	No	0	6	6
207	R:R:C243	R:R:I242	3.27	No	No	0	8	5
208	R:R:A174	R:R:I178	3.25	No	No	0	3	3
209	R:R:S214	R:R:V130	3.23	No	No	0	5	7
210	R:R:S140	R:R:T143	3.2	No	No	0	6	3
211	R:R:T159	R:R:V156	3.17	Yes	Yes	0	6	4
212	R:R:L30	R:R:S281	3	Yes	No	0	6	5
213	R:R:L66	R:R:V121	2.98	No	No	0	8	8
214	R:R:L245	R:R:V241	2.98	No	No	0	5	4
215	R:R:L257	R:R:V272	2.98	Yes	No	0	2	4
216	R:R:D124	R:R:S62	2.94	No	No	0	8	8
217	R:R:I212	R:R:I233	2.94	No	No	0	5	7
218	R:R:A224	R:R:H223	2.93	No	No	0	4	3
219	R:R:D85	R:R:V88	2.92	No	No	0	4	3
220	R:R:I238	R:R:M234	2.92	No	No	0	4	5
221	R:R:D273	R:R:V272	2.92	No	No	0	4	4
222	R:R:I39	R:R:L80	2.85	No	No	0	5	8
223	R:R:I147	R:R:L151	2.85	No	No	0	4	7
224	R:R:I230	R:R:L215	2.85	No	No	0	5	8
225	R:R:E196	R:R:M192	2.71	No	No	0	6	5
226	R:R:E37	R:R:L36	2.65	Yes	No	0	7	4
227	R:R:H184	R:R:I254	2.65	No	No	0	3	5
228	R:R:H223	R:R:I226	2.65	No	No	0	3	7
229	R:R:S300	R:R:Y295	2.54	No	No	0	6	5
230	R:R:I211	R:R:R125	2.51	No	No	0	8	9
231	R:R:F40	R:R:M288	2.49	No	No	0	5	6
232	R:R:F25	R:R:K28	2.48	No	No	0	5	3
233	R:R:F197	R:R:L245	2.44	Yes	No	0	8	5
234	R:R:F277	R:R:L274	2.44	Yes	No	0	5	3
235	R:R:H161	R:R:H189	2.39	No	No	0	8	5
236	R:R:D273	R:R:F277	2.39	No	Yes	0	4	5
237	R:R:A72	R:R:G113	1.95	No	No	0	8	6
238	R:R:A27	R:R:P31	1.87	No	No	0	4	6
239	R:R:G153	R:R:V156	1.84	No	Yes	0	4	4
240	R:R:G157	R:R:V156	1.84	No	Yes	0	4	4
241	R:R:G41	R:R:I77	1.76	No	Yes	0	8	5
242	R:R:G41	R:R:M288	1.75	No	No	0	8	6
243	R:R:G202	R:R:L201	1.71	No	Yes	0	3	6
244	R:R:C19	R:R:T263	1.69	No	No	0	3	3
245	R:R:M84	R:R:P81	1.68	No	No	0	7	9
246	R:R:A108	R:R:T159	1.68	No	Yes	0	5	6
247	R:R:S298	R:R:S300	1.63	No	No	0	8	6
248	R:R:S271	R:R:V268	1.62	No	No	0	2	1
249	R:R:S271	R:R:V272	1.62	No	No	0	2	4
250	R:R:V156	R:R:V160	1.6	Yes	No	0	4	4
251	R:R:V235	R:R:V292	1.6	No	No	0	5	6
252	R:R:V249	R:R:V250	1.6	No	No	0	5	4
253	R:R:C183	R:R:N17	1.57	No	No	0	1	6
254	R:R:I278	R:R:S281	1.55	No	No	0	5	5
255	R:R:H131	R:R:P132	1.53	No	No	0	6	8
256	R:R:F38	R:R:G35	1.51	Yes	No	0	6	5
257	R:R:P299	R:R:R228	1.44	No	No	0	5	7
258	R:R:I26	R:R:L30	1.43	No	Yes	0	4	6
259	R:R:Q264	R:R:T263	1.42	No	No	0	1	3
260	R:R:C79	R:R:F82	1.4	Yes	No	0	6	6
261	R:R:D221	R:R:M220	1.39	No	No	0	3	3
262	R:R:H259	R:R:T260	1.37	No	No	0	2	1
263	R:R:C266	R:R:Y269	1.34	No	No	0	6	4
264	R:R:F296	R:R:S297	1.32	No	No	0	7	6
265	R:R:R187	R:R:T185	1.29	No	No	0	1	4
266	R:R:F74	R:R:I78	1.26	No	No	0	7	4
267	R:R:I212	R:R:R216	1.25	No	No	0	5	4
268	R:R:K60	R:R:R63	1.24	No	No	0	7	7
269	R:R:K60	R:R:R128	1.24	No	No	0	7	8
270	R:R:F95	R:R:K94	1.24	No	No	0	7	3
271	R:R:F105	R:R:L102	1.22	No	No	0	5	4
272	R:R:T143	R:R:W142	1.21	No	No	0	3	4
273	R:R:F95	R:R:Y86	1.03	No	No	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	14.294	5	1	0
2	R:R:L30	3.045	4	0	6
3	R:R:E37	6.485	4	0	7
4	R:R:F38	4.694	5	1	6
5	R:R:W59	6.7	4	0	6
6	R:R:D73	9.225	4	0	9
7	R:R:I77	6.5225	4	0	5
8	R:R:C79	4.6475	4	0	6
9	R:R:W93	8.4875	4	0	9
10	R:R:F107	13.796	5	1	6
11	R:R:Y126	7.54	6	5	8
12	R:R:W152	6.69	5	4	9
13	R:R:T155	4.92	4	0	7
14	R:R:V156	2.1125	4	0	4
15	R:R:T159	3.69	4	0	6
16	R:R:F197	7.92	5	2	8
17	R:R:L201	5.5475	4	2	6
18	R:R:F232	8.978	5	0	7
19	R:R:F240	5.058	5	2	9
20	R:R:F244	7.07	4	0	9
21	R:R:L257	6.2325	4	9	2
22	R:R:R270	7.9375	4	3	2
23	R:R:F276	5.9725	4	6	4
24	R:R:F277	4.155	4	0	5
25	R:R:Y284	8.612	5	1	7
26	R:R:D290	9.63	4	0	9
27	R:R:Y294	7.0725	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W93	88.4219	13.44	Yes	Yes	0	0	9
2	R:R:N175	R:R:W93	80.5887	6.78	No	Yes	0	3	9
3	R:R:I178	R:R:N175	81.369	7.08	No	No	0	3	3
4	R:R:F21	R:R:I178	79.7744	7.54	No	No	0	3	3
5	R:R:F21	R:R:F277	78.2688	4.29	No	Yes	0	3	5
6	R:R:D273	R:R:F277	26.2988	2.39	No	Yes	0	4	5
7	R:R:D273	R:R:V272	20.0942	2.92	No	No	0	4	4
8	R:R:L257	R:R:V272	14.8055	2.98	Yes	No	0	2	4
9	L:L:?1	R:R:F107	55.4519	23.96	Yes	Yes	1	0	6
10	R:R:F107	R:R:F38	50.7019	4.29	Yes	Yes	1	6	6
11	R:R:F38	R:R:S287	89.7663	6.61	Yes	No	0	6	8
12	R:R:D73	R:R:S287	88.2098	4.42	Yes	No	0	9	8
13	R:R:D73	R:R:I77	58.8447	8.4	Yes	Yes	0	9	5
14	R:R:G41	R:R:I77	52.2456	1.76	No	Yes	0	8	5
15	R:R:G41	R:R:M288	50.4941	1.75	No	No	0	8	6
16	R:R:E37	R:R:M288	46.9655	12.18	Yes	No	0	7	6
17	R:R:E37	R:R:V33	36.1763	5.7	Yes	No	0	7	6
18	R:R:L30	R:R:V33	34.3484	4.47	Yes	No	0	6	6
19	R:R:L30	R:R:P31	26.9519	3.28	Yes	No	0	6	6
20	R:R:A27	R:R:P31	23.2029	1.87	No	No	0	4	6
21	L:L:?1	R:R:Y284	52.0718	9.23	Yes	Yes	1	0	7
22	R:R:F38	R:R:Y284	49.718	6.19	Yes	Yes	1	6	7
23	R:R:A27	R:R:D24	21.3156	6.18	No	No	0	4	4
24	R:R:D24	R:R:R90	19.4198	3.57	No	No	0	4	3
25	R:R:K28	R:R:R90	17.5156	14.85	No	No	0	3	3
26	R:R:K28	R:R:R89	11.752	17.33	No	No	0	3	4
27	R:R:D290	R:R:D73	24.5176	13.31	Yes	Yes	0	9	9
28	R:R:D290	R:R:P291	13.6817	12.88	Yes	No	0	9	9
29	R:R:G44	R:R:P291	11.752	4.06	No	No	0	7	9
30	L:L:?1	R:R:L104	100	7.26	Yes	No	0	0	5
31	R:R:L104	R:R:R101	99.5886	3.64	No	No	0	5	7
32	R:R:L163	R:R:R101	99.05	6.07	No	No	0	4	7
33	R:R:F105	R:R:L163	98.6344	4.87	No	No	0	5	4
34	R:R:F105	R:R:T159	97.642	3.89	No	Yes	0	5	6
35	R:R:M109	R:R:T159	94.4612	6.02	No	Yes	0	5	6
36	R:R:M109	R:R:T155	93.9014	6.02	No	Yes	0	5	7
37	R:R:T155	R:R:W152	42.576	4.85	Yes	Yes	0	7	9
38	R:R:V71	R:R:W152	37.2577	4.9	No	Yes	0	5	9
39	R:R:F67	R:R:V71	36.524	5.24	No	No	0	6	5
40	R:R:F52	R:R:F67	14.0634	5.36	No	No	0	7	6
41	R:R:F67	R:R:I51	22.6049	3.77	No	No	0	6	7
42	R:R:H55	R:R:I51	13.177	7.95	No	No	0	5	7
43	R:R:H55	R:R:R63	12.2524	11.28	No	No	0	5	7
44	R:R:I51	R:R:W59	14.5087	5.87	No	Yes	0	7	6
45	R:R:F52	R:R:W59	12.087	7.02	No	Yes	0	7	6
46	R:R:I64	R:R:W59	21.218	8.22	No	Yes	0	6	6
47	R:R:A144	R:R:I64	16.5613	4.87	No	No	0	8	6
48	R:R:A144	R:R:S61	14.2203	3.42	No	No	0	8	7
49	R:R:I139	R:R:S61	11.8707	6.19	No	No	0	7	7
50	R:R:I116	R:R:T155	52.4492	4.56	No	Yes	0	5	7
51	R:R:I116	R:R:L151	51.5204	4.28	No	No	0	5	7
52	R:R:L151	R:R:V120	47.7925	4.47	No	No	0	7	6
53	R:R:C177	R:R:W93	10.4627	3.92	No	Yes	0	9	9
54	R:R:C100	R:R:C177	10.0725	7.28	No	No	0	9	9
55	R:R:F276	R:R:F277	54.6673	7.5	Yes	Yes	0	4	5
56	R:R:F180	R:R:F276	49.3999	8.57	No	Yes	0	4	4
57	R:R:F180	R:R:S181	48.4499	5.28	No	No	0	4	5
58	R:R:R251	R:R:S181	47.3599	7.91	No	No	0	6	5
59	R:R:L194	R:R:R251	38.4961	3.64	No	No	0	4	6
60	R:R:L194	R:R:V248	36.1635	5.96	No	No	0	4	8
61	R:R:F197	R:R:V248	33.6868	18.35	Yes	No	2	8	8
62	R:R:F197	R:R:F240	26.2395	4.29	Yes	Yes	2	8	9
63	R:R:F240	R:R:I115	14.9667	5.02	Yes	No	0	9	8
64	R:R:F244	R:R:I115	13.6435	12.56	Yes	No	0	9	8
65	R:R:F65	R:R:V120	46.8637	9.18	No	No	0	6	6
66	R:R:D124	R:R:F65	46.1173	4.78	No	No	0	8	6
67	R:R:D124	R:R:R128	44.5905	10.72	No	No	0	8	8
68	R:R:N137	R:R:R128	47.6017	6.03	No	No	0	4	8
69	R:R:H134	R:R:N137	46.5669	3.83	No	No	0	5	4
70	R:R:F127	R:R:H134	45.5236	9.05	No	No	0	5	5
71	R:R:F127	R:R:Y126	43.4115	5.16	No	Yes	0	5	8
72	R:R:I211	R:R:Y126	28.941	3.63	No	Yes	0	8	8
73	R:R:I211	R:R:R125	26.549	2.51	No	No	0	8	9
74	R:R:F232	R:R:R125	25.3403	21.38	Yes	No	0	7	9
75	R:R:F232	R:R:I233	17.0703	3.77	Yes	No	0	7	7
76	R:R:I212	R:R:I233	14.5299	2.94	No	No	0	5	7
77	R:R:I212	R:R:I230	11.9725	7.36	No	No	0	5	5
78	R:R:I230	R:R:L215	10.6748	2.85	No	No	0	5	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:V83	17.58	1	Yes	No	0	6	0	1
L:L:?1	R:R:W93	13.44	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:L104	7.26	1	Yes	No	0	5	0	1
L:L:?1	R:R:F107	23.96	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y284	9.23	1	Yes	Yes	0	7	0	1
R:R:F107	R:R:F38	4.29	1	Yes	Yes	6	6	1	2
R:R:F38	R:R:Y284	6.19	1	Yes	Yes	6	7	2	1
R:R:F107	R:R:L76	20.7	1	Yes	No	6	6	1	2
R:R:C79	R:R:F107	5.59	0	Yes	Yes	6	6	2	1
R:R:V88	R:R:W93	9.81	0	No	Yes	3	9	2	1
R:R:N175	R:R:W93	6.78	0	No	Yes	3	9	2	1
R:R:C177	R:R:W93	3.92	0	No	Yes	9	9	2	1
R:R:L104	R:R:R101	3.64	0	No	No	5	7	1	2
R:R:F107	R:R:Y284	14.44	1	Yes	Yes	6	7	1	1
R:R:L280	R:R:T283	5.9	1	No	No	5	8	2	2
R:R:L280	R:R:Y284	8.21	1	No	Yes	5	7	2	1
R:R:T283	R:R:Y284	4.99	1	No	Yes	8	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9JKV_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.64
Number of Linked Nodes	258
Number of Links	273
Number of Hubs	27
Number of Links mediated by Hubs	102
Number of Communities	9
Number of Nodes involved in Communities	32
Number of Links involved in Communities	35

Path Summary
Number Of Nodes in MetaPath	79
Number Of Links MetaPath	78
Number of Shortest Paths	46852
Length Of Smallest Path	3
Average Path Length	20.232
Length of Longest Path	49
Minimum Path Strength	1.135
Average Path Strength	6.61129
Maximum Path Strength	22.33
Minimum Path Correlation	0.7
Average Path Correlation	0.930502
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.94118
Average % Of Corr. Nodes	38.8414
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	33.2459
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49019
Sequence	>9JKV_nogp_Chain_R N C C V F R D D F I A K V L P P V L G L E F I F G L L G N G L A L W I F C F H L K S W K S S R I F L F N L A V A D F L L I I C L P F V M D Y Y V R R S D W K F G D I P C R L V L F M F A M N R Q G S I I F L T V V A V D R Y F R V V H P H H A L N K I S N W T A A I I S C L L W G I T V G L T V H L L K N G T A N V C I S F S I C H T F R W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R Q M D R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I H I F W L L H T S G T Q N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IHJ	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.07	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHJ (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-		3.07	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	8IHK	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-	-	3.21	2023-08-30	doi.org/10.1038/s41467-023-41650-7
	9JKS	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 44250176	-	Gi1/β1/γ2	3.31	2025-10-29	To be published
	9JKS (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 44250176	-		3.31	2025-10-29	To be published
	9JKT	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	(2R)-2-hydroxy-3-phenylpropanoic acid	-	Gi1/β1/γ2	3.05	2025-10-29	To be published
	9JKT (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	(2R)-2-hydroxy-3-phenylpropanoic acid	-		3.05	2025-10-29	To be published
	9JKV	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 2736690	-	Gi1/β1/γ2	3.26	2025-10-29	To be published
	9JKV (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 2736690	-		3.26	2025-10-29	To be published
	9JKX	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.18	2025-10-29	To be published
	9JKX (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-		3.18	2025-10-29	To be published
	8JEF	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 11367166	-	Gi1/β1/γ2	2.96	2024-12-18	doi.org/10.1016/j.celrep.2024.114895
	8JEF (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	PubChem 11367166	-		2.96	2024-12-18	doi.org/10.1016/j.celrep.2024.114895
	9KT6	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-	Gi1/β1/γ2	3.01	2025-12-10	10.1021/acs.jmedchem.4c02567
	9KT6 (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Acifran	-		3.01	2025-12-10	10.1021/acs.jmedchem.4c02567
	9JIC	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	-	-	Gi1/β1/γ2	3.4	2025-12-17	10.1016/j.celrep.2024.114895
	9JIC (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	-	-		3.4	2025-12-17	10.1016/j.celrep.2024.114895
	9JID	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Niacin	-	Gi1/β1/γ2	2.78	2025-12-17	10.1016/j.celrep.2024.114895
	9JID (No Gprot)	A	Alicarboxylic acid	Hydroxycarboxylic Acid	HCA₃	Homo sapiens	Niacin	-		2.78	2025-12-17	10.1016/j.celrep.2024.114895

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9JKV_nogp.zip

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