Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:H125 5.43167619
2L:L:D127 5.022519
3L:L:F130 5.436519
4L:L:Y134 7.805418
5L:L:L137 2.635405
6L:L:L151 6.275408
7R:R:F27 4.025406
8R:R:Q31 4.28404
9R:R:I38 2.905466
10R:R:W64 12.9529
11R:R:P66 3.6375464
12R:R:R82 9.24667644
13R:R:F84 9.75445
14R:R:D107 8.4625403
15R:R:D110 6.9025404
16R:R:M111 5.5475403
17R:R:V113 2.1475401
18R:R:W123 15.3617629
19R:R:F131 10.66404
20R:R:Y149 3.235404
21R:R:Y150 4.45514
22R:R:Y157 7.8725408
23R:R:Y161 5.90625817
24R:R:F178 8.228536
25R:R:N186 5.13409
26R:R:M190 4.335486
27R:R:R199 5.35518
28R:R:K206 4.862516
29R:R:Y211 6.71167614
30R:R:V229 2.2975416
31R:R:M230 4.2725416
32R:R:F233 6.196516
33R:R:H234 6.3675417
34R:R:S239 5.51458
35R:R:Y241 8.09417
36R:R:W243 11.5233659
37R:R:I246 5.1575408
38R:R:Y250 6.51408
39R:R:F252 5.1225407
40R:R:F266 4.13406
41R:R:Y269 5.9525107
42R:R:W274 12.0725458
43R:R:P277 3.445409
44R:R:W284 5.74408
45R:R:W297 15.5425498
46R:R:D298 5.726516
47R:R:W306 8.61667615
48R:R:V314 2.105404
49R:R:I330 1.49408
50R:R:F362 7.274509
51R:R:H365 8.0575419
52R:R:Y366 10.154518
53R:R:F369 8.6375406
54R:R:R381 6.0975407
55R:R:L386 5.68418
56R:R:Q392 5.7375419
57R:R:E410 11.68538
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:H125 R:R:F233 10.32973.39YesYes196
2L:L:H125 R:R:Y241 62.81473.27YesYes197
3L:L:H125 R:R:W306 67.66324.23YesYes195
4L:L:D127 R:R:F233 44.76547.17YesYes196
5L:L:D127 R:R:Y161 14.86073.45YesYes197
6R:R:R199 R:R:Y241 58.46446.17YesYes187
7R:R:R199 R:R:Y161 22.56733.09YesYes187
8R:R:E374 R:R:W306 12.34097.63NoYes045
9R:R:Y157 R:R:Y161 12.28155.96YesYes087
10L:L:F130 R:R:Y157 10.745411.35YesYes098
11R:R:F233 R:R:K206 29.93057.44YesYes166
12L:L:T131 R:R:K206 11.45286.01NoYes196
13L:L:T131 R:R:D298 13.89774.34NoYes196
14R:R:K206 R:R:M230 12.10345.76YesYes166
15R:R:D298 R:R:M230 13.17224.16YesYes166
16R:R:N300 R:R:W306 83.264918.08NoYes065
17L:L:D132 R:R:N300 82.787312.12NoNo096
18L:L:D132 L:L:R136 87.59974.76NoNo099
19L:L:R136 R:R:P86 87.09114.32NoNo092
20R:R:D107 R:R:P86 86.07913.22YesNo032
21R:R:D107 R:R:D110 83.26239.31YesYes034
22R:R:D110 R:R:R82 71.47918.34YesYes044
23R:R:F84 R:R:R82 65.796616.03YesYes454
24L:L:K144 R:R:F84 64.65554.96NoYes085
25L:L:K144 R:R:F81 63.89387.44NoNo086
26L:L:L147 R:R:F81 62.355123.14NoNo096
27L:L:L147 L:L:L151 61.5782.77NoYes098
28L:L:L151 R:R:I61 57.61759.99YesNo084
29R:R:I61 R:R:N60 18.21191.42NoNo046
30L:L:I150 R:R:N60 17.181711.33NoNo066
31L:L:I150 L:L:Y146 15.1062.42NoNo068
32R:R:F131 R:R:I61 42.276621.35YesNo044
33R:R:F131 R:R:P126 35.86614.33YesNo045
34R:R:P126 R:R:R116 32.086321.62NoNo059
35R:R:R116 R:R:W123 29.057937.99NoYes299
36R:R:W123 R:R:W64 13.993224.37YesYes299
37R:R:K65 R:R:W64 11.17658.12NoYes079
38R:R:K65 R:R:P66 10.08181.67NoYes074
39R:R:C118 R:R:W123 12.94765.22NoYes299
40R:R:C118 R:R:C54 12.29447.28NoNo099
41R:R:D110 R:R:E79 16.18522.6YesNo042
42R:R:E79 R:R:M111 15.14211.35NoYes023
43R:R:M111 R:R:S76 10.91833.07YesNo034
44R:R:S390 R:R:Y161 13.3413.99NoYes097
45R:R:G160 R:R:S390 11.69033.71NoNo099
46R:R:F391 R:R:G160 10.03546.02NoNo079
47R:R:N240 R:R:R199 99.62059.64NoYes098
48R:R:N240 R:R:S195 1005.96NoNo099
49R:R:S195 R:R:W243 86.43028.65NoYes599
50R:R:I246 R:R:W243 86.98535.87YesYes089
51R:R:I246 R:R:Y269 84.62293.63YesYes087
52R:R:Y250 R:R:Y269 64.25277.94YesYes087
53R:R:I188 R:R:Y250 61.76397.25NoYes098
54R:R:E247 R:R:I188 53.84048.2NoNo099
55R:R:E247 R:R:H189 26.80927.39NoNo099
56R:R:H189 R:R:R185 19.68353.39NoNo099
57R:R:N186 R:R:R185 18.77734.82YesNo099
58R:R:L181 R:R:N186 16.39695.49NoYes099
59R:R:F266 R:R:I188 12.2663.77YesNo069
60R:R:F187 R:R:F266 12.65855.36NoYes066
61R:R:F187 R:R:H182 10.96744.53NoNo068
62R:R:Y265 R:R:Y269 16.236810.92NoYes047
63R:R:E262 R:R:Y265 11.85294.49NoNo064
64R:R:E262 R:R:F266 11.27463.5NoYes066
65R:R:E410 R:R:L181 10.272915.9YesNo389
66R:R:S195 R:R:S239 13.24194.89NoYes598
67R:R:C296 R:R:D298 22.16974.67NoYes096
68R:R:C226 R:R:C296 20.57427.28NoNo099
69R:R:C226 R:R:K227 18.40034.85NoNo097
70R:R:K227 R:R:W297 16.226526.69NoYes078
71R:R:P277 R:R:S239 12.1553.56YesYes098
72R:R:E247 R:R:L361 31.6017.95NoNo099
73R:R:F362 R:R:L361 22.39437.31YesNo099
74R:R:L249 R:R:Y269 10.24713.52NoYes1067
75R:R:R288 R:R:W297 12.942521.99NoYes088
76R:R:D107 R:R:L106 10.17221.36YesNo033
77R:R:F362 R:R:L358 18.68174.87YesNo099
78R:R:F324 R:R:L358 17.74466.09NoNo099
79R:R:F324 R:R:I328 11.158411.3NoNo097
80R:R:F233 R:R:H234 12.84189.05YesYes167
81R:R:H234 R:R:W306 11.16884.23YesYes175
82L:L:D127 R:R:R199 27.3414.76YesYes198
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:H125 R:R:F233 3.39 1 Yes Yes 9 6 0 1
L:L:H125 R:R:H234 4.78 1 Yes Yes 9 7 0 1
L:L:H125 R:R:V237 11.07 1 Yes No 9 6 0 1
L:L:H125 R:R:Y241 3.27 1 Yes Yes 9 7 0 1
L:L:H125 R:R:W306 4.23 1 Yes Yes 9 5 0 1
L:L:S126 R:R:E385 5.75 1 No No 9 8 0 1
L:L:S126 R:R:L386 6.01 1 No Yes 9 8 0 1
L:L:D127 R:R:Y161 3.45 1 Yes Yes 9 7 0 1
L:L:D127 R:R:R199 4.76 1 Yes Yes 9 8 0 1
L:L:D127 R:R:F233 7.17 1 Yes Yes 9 6 0 1
L:L:D127 R:R:L386 6.79 1 Yes Yes 9 8 0 1
L:L:V129 R:R:E374 7.13 0 No No 7 4 0 1
L:L:V129 R:R:L382 2.98 0 No No 7 5 0 1
L:L:F130 R:R:Y150 5.16 1 Yes Yes 9 4 0 1
L:L:F130 R:R:V153 3.93 1 Yes No 9 6 0 1
L:L:F130 R:R:Y157 11.35 1 Yes Yes 9 8 0 1
L:L:F130 R:R:L382 3.65 1 Yes No 9 5 0 1
L:L:T131 R:R:K206 6.01 1 No Yes 9 6 0 1
L:L:T131 R:R:Y211 3.75 1 No Yes 9 4 0 1
L:L:T131 R:R:D298 4.34 1 No Yes 9 6 0 1
L:L:D132 R:R:M299 4.16 0 No No 9 5 0 1
L:L:D132 R:R:N300 12.12 0 No No 9 6 0 1
L:L:N133 R:R:Y150 5.81 0 No Yes 8 4 0 1
L:L:N133 R:R:K378 13.99 0 No No 8 5 0 1
L:L:Y134 R:R:Y150 2.98 1 Yes Yes 8 4 0 1
L:L:Y134 R:R:Y211 15.89 1 Yes Yes 8 4 0 1
L:L:T135 R:R:D298 8.67 0 No Yes 9 6 0 1
L:L:T135 R:R:M299 6.02 0 No No 9 5 0 1
L:L:R136 R:R:P86 4.32 0 No No 9 2 0 1
L:L:R138 R:R:Y211 3.09 1 No Yes 8 4 0 1
L:L:Q140 R:R:F84 3.51 0 No Yes 7 5 0 1
L:L:K144 R:R:F81 7.44 0 No No 8 6 0 1
L:L:K144 R:R:F84 4.96 0 No Yes 8 5 0 1
L:L:Y146 R:R:F27 9.28 0 No Yes 8 6 0 1
L:L:Y146 R:R:Q31 5.64 0 No Yes 8 4 0 1
L:L:L147 R:R:F81 23.14 0 No No 9 6 0 1
L:L:I150 R:R:N60 11.33 0 No No 6 6 0 1
L:L:L151 R:R:I61 9.99 0 Yes No 8 4 0 1
R:R:K28 R:R:Q31 4.07 0 No Yes 3 4 2 1
R:R:A32 R:R:Q31 3.03 0 No Yes 2 4 2 1
R:R:Q31 R:R:W58 4.38 0 Yes No 4 7 1 2
R:R:F131 R:R:I61 21.35 0 Yes No 4 4 2 1
R:R:F84 R:R:R82 16.03 4 Yes Yes 5 4 1 2
R:R:N85 R:R:R82 7.23 4 No Yes 3 4 2 2
R:R:I83 R:R:P86 3.39 0 No No 4 2 2 1
R:R:F84 R:R:N85 14.5 4 Yes No 5 3 1 2
R:R:D107 R:R:P86 3.22 0 Yes No 3 2 2 1
R:R:D147 R:R:L151 6.79 0 No No 1 2 1 2
R:R:Y149 R:R:Y150 5.96 0 Yes Yes 4 4 2 1
R:R:L382 R:R:Y149 4.69 0 No Yes 5 4 1 2
R:R:K154 R:R:Y157 5.97 0 No Yes 5 8 2 1
R:R:D207 R:R:K154 9.68 0 No No 7 5 2 2
R:R:Y157 R:R:Y161 5.96 0 Yes Yes 8 7 1 1
R:R:L386 R:R:Y157 8.21 1 Yes Yes 8 8 1 1
R:R:R199 R:R:Y161 3.09 1 Yes Yes 8 7 1 1
R:R:A200 R:R:Y161 4 0 No Yes 8 7 2 1
R:R:V203 R:R:Y161 10.09 0 No Yes 7 7 2 1
R:R:F204 R:R:Y161 4.13 0 No Yes 7 7 2 1
R:R:S390 R:R:Y161 13.99 0 No Yes 9 7 2 1
R:R:N240 R:R:R199 9.64 0 No Yes 9 8 2 1
R:R:R199 R:R:Y241 6.17 1 Yes Yes 8 7 1 1
R:R:R199 R:R:Y366 3.09 1 Yes Yes 8 8 1 2
R:R:K206 R:R:Y211 3.58 1 Yes Yes 6 4 1 1
R:R:K206 R:R:M230 5.76 1 Yes Yes 6 6 1 2
R:R:F233 R:R:K206 7.44 1 Yes Yes 6 6 1 1
R:R:D207 R:R:Y211 5.75 0 No Yes 7 4 2 1
R:R:L210 R:R:Y211 8.21 1 No Yes 7 4 2 1
R:R:L210 R:R:M230 5.65 1 No Yes 7 6 2 2
R:R:D298 R:R:L210 6.79 1 Yes No 6 7 1 2
R:R:D298 R:R:M230 4.16 1 Yes Yes 6 6 1 2
R:R:F233 R:R:H234 9.05 1 Yes Yes 6 7 1 1
R:R:F233 R:R:V237 3.93 1 Yes No 6 6 1 1
R:R:H234 R:R:W284 7.41 1 Yes Yes 7 8 1 2
R:R:H234 R:R:W306 4.23 1 Yes Yes 7 5 1 1
R:R:V313 R:R:Y241 5.05 0 No Yes 7 7 2 1
R:R:Y241 R:R:Y366 17.87 1 Yes Yes 7 8 1 2
R:R:I309 R:R:W284 10.57 0 No Yes 7 8 2 2
R:R:C296 R:R:D298 4.67 0 No Yes 9 6 2 1
R:R:N300 R:R:W306 18.08 0 No Yes 6 5 1 1
R:R:I309 R:R:W306 10.57 0 No Yes 7 5 2 1
R:R:K310 R:R:W306 6.96 0 No Yes 6 5 2 1
R:R:E374 R:R:W306 7.63 0 No Yes 4 5 1 1
R:R:E385 R:R:Y366 10.1 0 No Yes 8 8 1 2
R:R:F369 R:R:R381 17.1 0 Yes Yes 6 7 2 2
R:R:E385 R:R:F369 8.16 0 No Yes 8 6 1 2
R:R:E374 R:R:R381 4.65 0 No Yes 4 7 1 2
R:R:K378 R:R:N375 6.99 0 No No 5 5 1 2
R:R:C25 R:R:F27 2.79 0 No Yes 4 6 2 1
L:L:A142 R:R:F27 2.77 0 No Yes 9 6 0 1
L:L:L137 R:R:D147 2.71 0 Yes No 5 1 0 1
L:L:L137 R:R:Q146 2.66 0 Yes No 5 1 0 1
L:L:V143 R:R:F81 2.62 0 No No 6 6 0 1
R:R:S164 R:R:Y161 2.54 0 No Yes 9 7 2 1
L:L:L137 R:R:Y150 2.34 0 Yes Yes 5 4 0 1
R:R:C236 R:R:V237 1.71 0 No No 5 6 2 1
R:R:G387 R:R:L386 1.71 0 No Yes 5 8 2 1
R:R:K206 R:R:V229 1.52 1 Yes Yes 6 6 1 2
R:R:M230 R:R:V229 1.52 1 Yes Yes 6 6 2 2
L:L:K139 R:R:M299 1.44 0 No No 8 5 0 1
R:R:I61 R:R:N60 1.42 0 No No 4 6 1 1
L:L:L151 R:R:D132 1.36 0 Yes No 8 6 0 1
R:R:F27 R:R:I26 1.26 0 Yes No 6 5 1 2
R:R:D132 R:R:H129 1.26 0 No No 6 2 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9P92_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.89
Number of Linked Nodes 359
Number of Links 409
Number of Hubs 57
Number of Links mediated by Hubs 210
Number of Communities 11
Number of Nodes involved in Communities 67
Number of Links involved in Communities 91
Path Summary
Number Of Nodes in MetaPath 83
Number Of Links MetaPath 82
Number of Shortest Paths 84639
Length Of Smallest Path 3
Average Path Length 17.5466
Length of Longest Path 47
Minimum Path Strength 1.145
Average Path Strength 7.37571
Maximum Path Strength 31.18
Minimum Path Correlation 0.7
Average Path Correlation 0.964278
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.125
Average % Of Corr. Nodes 60.5209
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 44.6132
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• vasoactive intestinal polypeptide receptor binding   • protein binding   • binding   • signaling receptor binding   • type 2 vasoactive intestinal polypeptide receptor binding   • G protein-coupled receptor binding   • neuropeptide receptor binding   • hormone activity   • molecular function activator activity   • molecular function regulator activity   • signaling receptor regulator activity   • receptor ligand activity   • signaling receptor activator activity   • neuropeptide hormone activity   • neuropeptide activity   • peptide hormone receptor binding   • hormone receptor binding   • type 1 vasoactive intestinal polypeptide receptor binding   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • body fluid secretion   • localization
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • body fluid secretion   • localization   • regulation of body fluid levels   • secretion   • transport   • regulation of biological quality   • establishment of localization   • cell population proliferation   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • positive regulation of biological process   • positive regulation of cellular process   • establishment of protein localization   • nitrogen compound transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • secretion by cell   • signal release   • intracellular protein localization   • regulation of hormone levels   • prolactin secretion   • establishment of protein localization to extracellular region   • cell-cell signaling   • export from cell   • protein secretion   • peptide transport   • protein transport   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of localization   • regulation of protein localization   • monoamine transport   • epinephrine secretion   • organic hydroxy compound transport   • organic cation transport   • catecholamine secretion   • catecholamine transport   • epinephrine transport   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • intracellular signal transduction   • positive regulation of cAMP/PKA signal transduction   • positive regulation of response to stimulus   • cAMP/PKA signal transduction   • regulation of intracellular signal transduction   • intracellular signaling cassette   • regulation of signaling   • positive regulation of intracellular signal transduction   • regulation of cAMP/PKA signal transduction   • regulation of response to stimulus   • regulation of cell communication   • positive regulation of signaling   • catabolic process   • positive regulation of protein metabolic process   • macromolecule catabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • positive regulation of macromolecule metabolic process   • protein metabolic process   • regulation of protein metabolic process   • primary metabolic process   • regulation of macromolecule metabolic process   • protein catabolic process   • regulation of catabolic process   • positive regulation of protein catabolic process   • positive regulation of catabolic process   • metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • regulation of protein catabolic process   • negative regulation of biological process   • positive regulation of macromolecule biosynthetic process   • nucleobase-containing compound metabolic process   • post-transcriptional regulation of gene expression   • regulation of RNA metabolic process   • negative regulation of nucleobase-containing compound metabolic process   • regulation of nucleobase-containing compound metabolic process   • RNA catabolic process   • mRNA stabilization   • mRNA catabolic process   • negative regulation of metabolic process   • nucleobase-containing compound catabolic process   • regulation of gene expression   • negative regulation of gene expression   • biosynthetic process   • negative regulation of macromolecule biosynthetic process   • nucleic acid catabolic process   • regulation of macromolecule biosynthetic process   • negative regulation of RNA metabolic process   • RNA metabolic process   • negative regulation of mRNA metabolic process   • regulation of mRNA catabolic process   • positive regulation of biosynthetic process   • negative regulation of cellular process   • negative regulation of macromolecule metabolic process   • regulation of biosynthetic process   • negative regulation of catabolic process   • negative regulation of mRNA catabolic process   • negative regulation of RNA catabolic process   • gene expression   • mRNA metabolic process   • macromolecule biosynthetic process   • nucleic acid metabolic process   • regulation of mRNA stability   • RNA stabilization   • negative regulation of biosynthetic process   • positive regulation of gene expression   • regulation of RNA stability   • regulation of mRNA metabolic process   • cellular anatomical structure   • extracellular region   • extracellular space   • cell projection   • neuron projection   • plasma membrane bounded cell projection   • small GTPase binding   • protein binding   • binding   • enzyme binding   • GTPase binding   • molecular transducer activity   • signaling receptor activity   • adenylate cyclase binding   • vasoactive intestinal polypeptide receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • neuropeptide binding   • peptide binding   • peptide hormone binding   • hormone binding   • peptide receptor activity   • G protein-coupled peptide receptor activity   • pituitary adenylate cyclase-activating polypeptide receptor activity   • response to chemical   • response to xenobiotic stimulus   • developmental process   • spermatogenesis   • sexual reproduction   • reproductive process   • multicellular organismal reproductive process   • developmental process involved in reproduction   • male gamete generation   • gamete generation   • cellular developmental process   • cell differentiation   • multicellular organismal process   • response to stress   • multicellular organismal response to stress   • response to alcohol   • response to oxygen-containing compound   • response to ethanol   • cell surface receptor signaling pathway   • regulation of calcium ion transport   • positive regulation of cation transmembrane transport   • positive regulation of calcium ion transport   • cellular localization   • regulation of calcium ion transport into cytosol   • monoatomic ion transmembrane transport   • regulation of monoatomic ion transmembrane transport   • calcium ion transport   • metal ion transport   • monoatomic cation transmembrane transport   • regulation of calcium ion transmembrane transport   • positive regulation of monoatomic ion transport   • positive regulation of calcium ion transmembrane transport   • positive regulation of transmembrane transport   • monoatomic ion transport   • positive regulation of monoatomic ion transmembrane transport   • monoatomic cation transport   • regulation of metal ion transport   • calcium ion transmembrane import into cytosol   • regulation of transport   • regulation of monoatomic ion transport   • positive regulation of cytosolic calcium ion concentration   • transmembrane transport   • positive regulation of calcium ion transport into cytosol   • regulation of transmembrane transport   • positive regulation of transport   • regulation of cellular localization   • regulation of monoatomic cation transmembrane transport   • calcium ion transmembrane transport   • calcium ion transport into cytosol   • small GTPase-mediated signal transduction   • regulation of small GTPase mediated signal transduction   • positive regulation of small GTPase mediated signal transduction   • multicellular organism development   • development of primary sexual characteristics   • sex differentiation   • anatomical structure development   • female sex differentiation   • development of primary female sexual characteristics   • regulation of inositol phosphate biosynthetic process   • alcohol metabolic process   • positive regulation of phosphate metabolic process   • inositol phosphate metabolic process   • regulation of small molecule metabolic process   • phosphate-containing compound metabolic process   • polyol biosynthetic process   • small molecule metabolic process   • phosphorus metabolic process   • regulation of carbohydrate metabolic process   • carbohydrate metabolic process   • polyol metabolic process   • positive regulation of phosphorus metabolic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • carbohydrate biosynthetic process   • positive regulation of inositol phosphate biosynthetic process   • organophosphate metabolic process   • organophosphate biosynthetic process   • inositol phosphate biosynthetic process   • alcohol biosynthetic process   • regulation of phosphorus metabolic process   • positive regulation of carbohydrate metabolic process   • regulation of carbohydrate biosynthetic process   • positive regulation of small molecule metabolic process   • positive regulation of alcohol biosynthetic process   • response to lipid   • response to estradiol   • negative regulation of response to reactive oxygen species   • negative regulation of response to stimulus   • response to reactive oxygen species   • response to oxidative stress   • regulation of response to reactive oxygen species   • regulation of response to stress   • regulation of response to oxidative stress   • negative regulation of response to oxidative stress   • cell surface   • membrane microdomain   • cell periphery   • membrane raft   • plasma membrane raft   • membrane   • plasma membrane   • plasma membrane region   • caveola   • protein-containing complex   • receptor complex   • membrane-bounded organelle   • intracellular anatomical structure   • endosome   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • cytoplasmic vesicle   • organelle   • cytoplasm   • vesicle   • cell-cell junction   • apical junction complex   • bicellular tight junction   • tight junction   • anchoring junction   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to ketone   • response to prostaglandin   • response to endogenous stimulus   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular membrane-bounded organelle   • synapse   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • system development   • Ras protein signal transduction   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • organelle membrane   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • molecular function regulator activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • cellular homeostasis   • chemical homeostasis   • homeostatic process   • glucose homeostasis   • carbohydrate homeostasis   • intracellular chemical homeostasis   • intracellular glucose homeostasis   • neuromuscular process   • regulation of system process   • skeletal muscle contraction   • muscle contraction   • muscle system process   • regulation of muscle system process   • striated muscle contraction   • multicellular organismal movement   • musculoskeletal movement   • regulation of striated muscle contraction   • regulation of muscle contraction   • regulation of skeletal muscle contraction   • regulation of multicellular organismal process   • sensory perception of smell   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • skeletal system development   • bone development   • response to pH   • cellular response to pH   • response to abiotic stimulus   • cellular response to acidic pH   • response to acidic pH   • cellular response to abiotic stimulus   • cellular response to environmental stimulus   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • coagulation   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • positive regulation of establishment of protein localization   • establishment of localization in cell   • positive regulation of insulin secretion involved in cellular response to glucose stimulus   • positive regulation of insulin secretion   • regulation of peptide hormone secretion   • positive regulation of peptide hormone secretion   • regulation of protein secretion   • regulation of secretion   • cellular response to carbohydrate stimulus   • response to glucose   • positive regulation of protein localization   • insulin secretion involved in cellular response to glucose stimulus   • regulation of hormone secretion   • regulation of peptide secretion   • positive regulation of secretion by cell   • positive regulation of protein transport   • regulation of secretion by cell   • positive regulation of hormone secretion   • response to monosaccharide   • response to carbohydrate   • positive regulation of secretion   • cellular response to hexose stimulus   • cellular response to monosaccharide stimulus   • positive regulation of peptide secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • cellular response to glucose stimulus   • regulation of protein transport   • positive regulation of protein secretion   • response to hexose   • regulation of insulin secretion   • regulation of insulin secretion involved in cellular response to glucose stimulus   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • serotonin receptor signaling pathway   • adenylate cyclase-activating serotonin receptor signaling pathway   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • inflammatory response to antigenic stimulus   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • bile acid signaling pathway   • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway   • renal system process   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • trans-Golgi network
Gene OntologyCellular Component
SCOP2Domain Identifier• FnI-like domain   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• FnI-like domain   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainL
ProteinVIP
UniProtP01282
Sequence
>9P92_nogp_Chain_L
HSDAVFTDN YTRLRKQMA VKKYLNSIL N


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP41586
Sequence
>9P92_nogp_Chain_R
DCIFKKEQA MCLEKIQRA NCPGMWDNI TCWKPAHVG EMVLVSCPE 
LFRIFNPDQ VWETETIGE SDFGDSNSL DLSDMGVVS RNCTEDGWS 
EPFPHYFDA CGDQDYYYL SVKALYTVG YSTSLVTLT TAMVILCRF 
RKLHCTRNF IHMNLFVSF MLRAISVFI KDWILYAST VECKAVMVF 
FHYCVVSNY FWLFIEGLY LFTLLVETF FPERRYFYW YTIIGWGTP 
TVCVTVWAT LRLYFDDTG CWDMNDSTA LWWVIKGPV VGSIMVNFV 
LFIGIIVIL VQKLQSPIY LRLARSTLL LIPLFGIHY TVFAFSPEN 
VSKRERLVF ELGLGSFQG FVVAVLYCF LNGEVQAEI KRKWRSW


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6P9YB1PeptideVIP and PACAPPAC1Homo sapiensPACAP27-Gs/β1/γ23.012020-02-05doi.org/10.1016/j.molcel.2020.01.012
6P9Y (No Gprot) B1PeptideVIP and PACAPPAC1Homo sapiensPACAP27-3.012020-02-05doi.org/10.1016/j.molcel.2020.01.012
6LPBB1PeptideVIP and PACAPPAC1Homo sapiensPACAP27-Gs/β1/γ13.92020-03-11doi.org/10.1038/s41594-020-0386-8
6LPB (No Gprot) B1PeptideVIP and PACAPPAC1Homo sapiensPACAP27-3.92020-03-11doi.org/10.1038/s41594-020-0386-8
6M1HB1PeptideVIP and PACAPPAC1Homo sapiensMaxadilan-Gs/β1/γ23.62020-03-11doi.org/10.1038/s41422-020-0280-2
6M1H (No Gprot) B1PeptideVIP and PACAPPAC1Homo sapiensMaxadilan-3.62020-03-11doi.org/10.1038/s41422-020-0280-2
6M1IB1PeptideVIP and PACAPPAC1Homo sapiensPACAP27-Gs/β1/γ23.52020-03-11doi.org/10.1038/s41422-020-0280-2
6M1I (No Gprot) B1PeptideVIP and PACAPPAC1Homo sapiensPACAP27-3.52020-03-11doi.org/10.1038/s41422-020-0280-2
8E3XB1PeptideVIP and PACAPPAC1Homo sapiensPACAP27-Gs/β1/γ22.32022-11-23doi.org/10.1038/s41467-022-34629-3
8E3X (No Gprot) B1PeptideVIP and PACAPPAC1Homo sapiensPACAP27-2.32022-11-23doi.org/10.1038/s41467-022-34629-3
9P92B1PeptideVIP and PACAPPAC1Homo sapiensVIP-Gs/β1/γ23.82025-11-1910.1073/pnas.2521157122
9P92 (No Gprot) B1PeptideVIP and PACAPPAC1Homo sapiensVIP-3.82025-11-1910.1073/pnas.2521157122
9P93B1PeptideVIP and PACAPPAC1Homo sapiensVIP-Gs/β1/γ23.22025-11-1910.1073/pnas.2521157122
9P93 (No Gprot) B1PeptideVIP and PACAPPAC1Homo sapiensVIP-3.22025-11-1910.1073/pnas.2521157122
9P94B1PeptideVIP and PACAPPAC1Homo sapiensPACAP27-Gs/β1/γ232025-11-1910.1073/pnas.2521157122
9P94 (No Gprot) B1PeptideVIP and PACAPPAC1Homo sapiensPACAP27-32025-11-1910.1073/pnas.2521157122




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