psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:D127	L:L:H125	3.78	Yes	Yes	1	9	9
2	L:L:A128	L:L:H125	7.32	No	Yes	0	8	9
3	L:L:H125	R:R:F233	4.53	Yes	Yes	1	9	6
4	L:L:H125	R:R:H234	5.97	Yes	Yes	1	9	7
5	L:L:H125	R:R:V237	17.99	Yes	No	1	9	6
6	L:L:H125	R:R:Y241	3.27	Yes	Yes	1	9	7
7	L:L:D127	L:L:S126	4.42	Yes	No	1	9	9
8	L:L:S126	R:R:E385	7.19	No	Yes	1	9	8
9	L:L:S126	R:R:L386	6.01	No	Yes	1	9	8
10	L:L:D127	R:R:Y161	3.45	Yes	Yes	1	9	7
11	L:L:D127	R:R:R199	11.91	Yes	Yes	1	9	8
12	L:L:D127	R:R:F233	4.78	Yes	Yes	1	9	6
13	L:L:D127	R:R:L386	5.43	Yes	Yes	1	9	8
14	L:L:A128	R:R:W306	3.89	No	Yes	0	8	5
15	L:L:V129	R:R:E374	5.7	No	No	0	7	4
16	L:L:V129	R:R:R381	6.54	No	No	0	7	7
17	L:L:V129	R:R:L382	5.96	No	No	0	7	5
18	L:L:F130	L:L:Y134	3.09	Yes	Yes	1	9	8
19	L:L:F130	R:R:Y150	6.19	Yes	Yes	1	9	4
20	L:L:F130	R:R:V153	3.93	Yes	No	0	9	6
21	L:L:F130	R:R:Y157	7.22	Yes	Yes	1	9	8
22	L:L:T131	R:R:K206	9.01	No	Yes	0	9	6
23	L:L:D132	L:L:R136	5.96	No	No	3	9	9
24	L:L:D132	R:R:M299	5.54	No	No	3	9	5
25	L:L:N133	R:R:Y150	5.81	No	Yes	1	8	4
26	L:L:N133	R:R:K378	6.99	No	No	1	8	5
27	L:L:N133	R:R:L382	4.12	No	No	0	8	5
28	L:L:R138	L:L:Y134	7.2	No	Yes	1	8	8
29	L:L:Y134	R:R:D147	3.45	Yes	No	0	8	1
30	L:L:Y134	R:R:Y150	3.97	Yes	Yes	1	8	4
31	L:L:Y134	R:R:Y211	11.91	Yes	Yes	1	8	4
32	L:L:T135	R:R:D298	5.78	No	Yes	0	9	6
33	L:L:T135	R:R:M299	3.01	No	No	0	9	5
34	L:L:Q140	L:L:R136	3.5	No	No	3	7	9
35	L:L:R136	R:R:M299	6.2	No	No	3	9	5
36	L:L:L137	R:R:D147	4.07	No	No	0	5	1
37	L:L:R138	R:R:Y211	14.4	No	Yes	1	8	4
38	L:L:K139	R:R:I83	5.82	No	No	0	8	4
39	L:L:Q140	R:R:I83	12.35	No	No	3	7	4
40	L:L:Q140	R:R:F84	22.25	No	No	3	7	5
41	L:L:M141	R:R:D147	5.54	No	No	0	8	1
42	L:L:K144	R:R:F81	3.72	No	Yes	0	8	6
43	L:L:K144	R:R:F84	16.13	No	No	0	8	5
44	L:L:I150	L:L:Y146	14.51	No	Yes	0	6	8
45	L:L:L147	R:R:F81	3.65	No	Yes	4	9	6
46	L:L:L147	R:R:F131	6.09	No	No	4	9	4
47	L:L:I150	R:R:N60	4.25	No	No	0	6	6
48	R:R:C25	R:R:K28	4.85	No	No	0	4	3
49	R:R:F27	R:R:L80	3.65	No	No	0	6	5
50	R:R:C34	R:R:C63	7.28	No	No	2	9	9
51	R:R:L35	R:R:W58	10.25	No	No	0	2	7
52	R:R:K37	R:R:R40	3.71	No	No	0	4	5
53	R:R:G56	R:R:I38	3.53	Yes	No	2	5	6
54	R:R:I38	R:R:P66	3.39	No	No	2	6	4
55	R:R:C118	R:R:C54	7.28	No	No	2	9	9
56	R:R:C54	R:R:W123	7.84	No	Yes	2	9	9
57	R:R:G56	R:R:P66	6.09	Yes	No	2	5	4
58	R:R:M57	R:R:W123	9.31	No	Yes	0	6	9
59	R:R:D59	R:R:T62	5.78	Yes	No	2	9	5
60	R:R:D59	R:R:W64	5.58	Yes	Yes	2	9	9
61	R:R:D59	R:R:R116	5.96	Yes	Yes	2	9	9
62	R:R:F131	R:R:I61	20.09	No	No	0	4	4
63	R:R:T62	R:R:W64	7.28	No	Yes	2	5	9
64	R:R:P78	R:R:T62	3.5	No	No	0	9	5
65	R:R:V73	R:R:W64	12.26	No	Yes	0	8	9
66	R:R:V75	R:R:W64	7.36	No	Yes	0	6	9
67	R:R:R116	R:R:W64	19.99	Yes	Yes	2	9	9
68	R:R:W123	R:R:W64	12.18	Yes	Yes	2	9	9
69	R:R:D110	R:R:S76	8.83	No	No	0	4	4
70	R:R:G112	R:R:S76	3.71	No	No	0	6	4
71	R:R:C77	R:R:F81	4.19	No	Yes	0	9	6
72	R:R:C134	R:R:C77	7.28	No	No	0	9	9
73	R:R:E79	R:R:L80	6.63	No	No	0	2	5
74	R:R:F131	R:R:F81	15	No	Yes	4	4	6
75	R:R:D110	R:R:R82	3.57	No	No	0	4	4
76	R:R:F84	R:R:I83	5.02	No	No	3	5	4
77	R:R:N85	R:R:P86	4.89	No	No	0	3	2
78	R:R:D87	R:R:N85	9.42	No	No	0	2	3
79	R:R:S115	R:R:Y130	6.36	No	No	0	5	8
80	R:R:R116	R:R:W123	11	Yes	Yes	2	9	9
81	R:R:P126	R:R:R116	7.21	No	Yes	0	5	9
82	R:R:C118	R:R:W123	6.53	No	Yes	2	9	9
83	R:R:D121	R:R:E120	9.09	No	No	0	4	1
84	R:R:P128	R:R:Y130	12.52	No	No	0	4	8
85	R:R:G144	R:R:T143	3.64	No	No	0	1	2
86	R:R:S152	R:R:Y148	8.9	No	No	0	4	1
87	R:R:Y149	R:R:Y150	9.93	Yes	Yes	0	4	4
88	R:R:V153	R:R:Y149	6.31	No	Yes	0	6	4
89	R:R:R379	R:R:Y149	23.66	No	Yes	0	4	4
90	R:R:L382	R:R:Y149	3.52	No	Yes	0	5	4
91	R:R:V383	R:R:Y149	3.79	No	Yes	0	5	4
92	R:R:K378	R:R:Y150	4.78	No	Yes	1	5	4
93	R:R:K154	R:R:Y157	4.78	No	Yes	0	5	8
94	R:R:K154	R:R:Y211	7.17	No	Yes	0	5	4
95	R:R:G387	R:R:L156	3.42	No	No	0	5	6
96	R:R:Y157	R:R:Y161	3.97	Yes	Yes	1	8	7
97	R:R:V203	R:R:Y157	5.05	Yes	Yes	1	7	8
98	R:R:D207	R:R:Y157	5.75	Yes	Yes	1	7	8
99	R:R:L386	R:R:Y157	14.07	Yes	Yes	1	8	8
100	R:R:S390	R:R:Y157	3.82	No	Yes	1	9	8
101	R:R:F391	R:R:G160	9.03	No	No	0	7	9
102	R:R:R199	R:R:Y161	5.14	Yes	Yes	1	8	7
103	R:R:V203	R:R:Y161	3.79	Yes	Yes	1	7	7
104	R:R:L386	R:R:Y161	3.52	Yes	Yes	1	8	7
105	R:R:S390	R:R:Y161	11.45	No	Yes	1	9	7
106	R:R:F204	R:R:S162	3.96	No	No	0	7	7
107	R:R:F394	R:R:T163	3.89	No	No	0	5	5
108	R:R:G393	R:R:S164	3.71	No	No	0	9	9
109	R:R:A200	R:R:L165	4.73	No	No	0	8	7
110	R:R:F394	R:R:T167	9.08	No	No	0	5	7
111	R:R:A397	R:R:T167	3.36	No	No	0	9	7
112	R:R:F193	R:R:L168	4.87	No	Yes	0	8	9
113	R:R:F196	R:R:L168	3.65	Yes	Yes	0	8	9
114	R:R:G393	R:R:L168	5.13	No	Yes	0	9	9
115	R:R:A397	R:R:L168	3.15	No	Yes	0	9	9
116	R:R:M197	R:R:T169	4.52	No	No	0	7	4
117	R:R:F402	R:R:T170	5.19	No	No	0	8	5
118	R:R:A171	R:R:C401	3.61	No	No	0	9	9
119	R:R:R177	R:R:V173	6.54	No	No	0	3	1
120	R:R:F402	R:R:I174	5.02	No	No	0	8	8
121	R:R:L175	R:R:N186	4.12	Yes	No	0	8	9
122	R:R:L175	R:R:M190	5.65	Yes	No	0	8	6
123	R:R:C401	R:R:L175	3.17	No	Yes	0	9	8
124	R:R:F178	R:R:L181	4.87	Yes	Yes	6	6	9
125	R:R:E410	R:R:F178	15.16	No	Yes	6	8	6
126	R:R:F178	R:R:K414	8.69	Yes	No	0	6	5
127	R:R:H182	R:R:R179	11.28	No	No	0	8	8
128	R:R:E410	R:R:K180	10.8	No	No	0	8	7
129	R:R:K180	R:R:R413	7.43	No	No	0	7	7
130	R:R:L181	R:R:V407	4.47	Yes	No	0	9	9
131	R:R:E410	R:R:L181	13.25	No	Yes	6	8	9
132	R:R:F187	R:R:H182	4.53	No	No	0	6	8
133	R:R:C183	R:R:R185	5.57	No	No	5	8	9
134	R:R:C183	R:R:N186	6.3	No	No	5	8	9
135	R:R:T184	R:R:Y250	6.24	No	No	0	7	8
136	R:R:N186	R:R:R185	8.44	No	No	5	9	9
137	R:R:H189	R:R:R185	6.77	No	No	0	9	9
138	R:R:F187	R:R:F266	4.29	No	No	0	6	6
139	R:R:I188	R:R:W243	4.7	No	Yes	0	9	9
140	R:R:E247	R:R:I188	6.83	No	No	0	9	9
141	R:R:F266	R:R:I188	5.02	No	No	0	6	9
142	R:R:E247	R:R:H189	7.39	No	No	0	9	9
143	R:R:N191	R:R:W243	14.69	No	Yes	0	8	9
144	R:R:F196	R:R:L192	6.09	Yes	No	0	8	9
145	R:R:L192	R:R:L244	4.15	No	No	0	9	9
146	R:R:N240	R:R:S195	7.45	Yes	No	0	9	9
147	R:R:S195	R:R:W243	4.94	No	Yes	0	9	9
148	R:R:F196	R:R:N240	14.5	Yes	Yes	0	8	9
149	R:R:F196	R:R:Q392	7.03	Yes	No	0	8	9
150	R:R:F232	R:R:L198	3.65	No	No	7	4	7
151	R:R:C236	R:R:L198	6.35	No	No	7	5	7
152	R:R:R199	R:R:V237	9.15	Yes	No	1	8	6
153	R:R:N240	R:R:R199	9.64	Yes	Yes	0	9	8
154	R:R:R199	R:R:Y241	6.17	Yes	Yes	1	8	7
155	R:R:R199	R:R:Y366	3.09	Yes	Yes	1	8	8
156	R:R:S202	R:R:V203	3.23	No	Yes	0	6	7
157	R:R:F233	R:R:S202	6.61	Yes	No	0	6	6
158	R:R:C236	R:R:S202	6.89	No	No	0	5	6
159	R:R:D207	R:R:V203	4.38	Yes	Yes	1	7	7
160	R:R:I205	R:R:V229	4.61	No	No	0	6	6
161	R:R:D207	R:R:K206	5.53	Yes	Yes	0	7	6
162	R:R:K206	R:R:L210	4.23	Yes	No	0	6	7
163	R:R:F233	R:R:K206	8.69	Yes	Yes	0	6	6
164	R:R:D207	R:R:Y211	5.75	Yes	Yes	1	7	4
165	R:R:I209	R:R:V229	3.07	No	No	0	5	6
166	R:R:L210	R:R:Y211	9.38	No	Yes	0	7	4
167	R:R:D298	R:R:L210	13.57	Yes	No	0	6	7
168	R:R:G295	R:R:S222	3.71	No	No	0	4	6
169	R:R:C226	R:R:T223	3.38	No	No	0	9	3
170	R:R:C226	R:R:C296	7.28	No	No	0	9	9
171	R:R:D293	R:R:K227	5.53	No	No	1	6	7
172	R:R:K227	R:R:W297	17.4	No	Yes	1	7	8
173	R:R:F233	R:R:M230	3.73	Yes	No	0	6	6
174	R:R:D298	R:R:M230	6.93	Yes	No	0	6	6
175	R:R:V231	R:R:V281	3.21	No	No	0	6	7
176	R:R:C236	R:R:F232	8.38	No	No	7	5	4
177	R:R:F233	R:R:H234	11.31	Yes	Yes	1	6	7
178	R:R:F233	R:R:V237	3.93	Yes	No	1	6	6
179	R:R:H234	R:R:W284	5.29	Yes	Yes	1	7	8
180	R:R:H234	R:R:W306	3.17	Yes	Yes	0	7	5
181	R:R:W274	R:R:Y235	3.86	Yes	Yes	0	8	9
182	R:R:P277	R:R:Y235	4.17	Yes	Yes	0	9	9
183	R:R:T278	R:R:Y235	7.49	No	Yes	0	4	9
184	R:R:P277	R:R:V238	8.84	Yes	No	0	9	6
185	R:R:C280	R:R:V238	5.12	No	No	0	5	6
186	R:R:S239	R:R:W274	4.94	No	Yes	0	8	8
187	R:R:L244	R:R:N240	4.12	No	Yes	0	9	9
188	R:R:V313	R:R:Y241	5.05	No	Yes	0	7	7
189	R:R:I317	R:R:Y241	4.84	Yes	Yes	1	7	7
190	R:R:Y241	R:R:Y366	16.88	Yes	Yes	1	7	8
191	R:R:F242	R:R:T276	7.78	No	No	0	5	4
192	R:R:I246	R:R:W243	3.52	Yes	Yes	0	8	9
193	R:R:W243	R:R:W274	20.62	Yes	Yes	0	9	8
194	R:R:F245	R:R:I246	3.77	Yes	Yes	0	8	8
195	R:R:F245	R:R:L249	4.87	Yes	No	0	8	6
196	R:R:F245	R:R:S316	3.96	Yes	No	0	8	7
197	R:R:F245	R:R:V319	6.55	Yes	No	0	8	6
198	R:R:I246	R:R:Y269	7.25	Yes	Yes	0	8	7
199	R:R:E247	R:R:L361	5.3	No	No	0	9	9
200	R:R:F362	R:R:G248	4.52	Yes	No	0	9	9
201	R:R:L249	R:R:Y269	8.21	No	Yes	0	6	7
202	R:R:L254	R:R:Y250	16.41	No	No	0	7	8
203	R:R:Y250	R:R:Y269	3.97	No	Yes	0	8	7
204	R:R:I327	R:R:L251	7.14	Yes	No	0	9	9
205	R:R:F252	R:R:V256	5.24	No	No	0	7	6
206	R:R:F252	R:R:L323	13.4	No	No	0	7	8
207	R:R:T253	R:R:Y269	3.75	No	Yes	0	7	7
208	R:R:I327	R:R:L255	4.28	Yes	No	0	9	8
209	R:R:I330	R:R:L255	4.28	Yes	No	0	8	8
210	R:R:E257	R:R:F260	3.5	No	No	9	5	6
211	R:R:E257	R:R:R263	8.14	No	No	9	5	4
212	R:R:F259	R:R:T258	9.08	No	No	0	7	7
213	R:R:F259	R:R:F260	3.22	No	No	0	7	6
214	R:R:F260	R:R:R263	11.76	No	No	9	6	4
215	R:R:E262	R:R:Y265	4.49	No	Yes	0	6	4
216	R:R:R263	R:R:Y265	19.55	No	Yes	0	4	4
217	R:R:F266	R:R:T270	7.78	No	No	0	6	5
218	R:R:W268	R:R:Y267	11.58	No	No	0	3	3
219	R:R:I271	R:R:Y267	10.88	No	No	0	4	3
220	R:R:T270	R:R:W274	3.64	No	Yes	0	5	8
221	R:R:P277	R:R:T276	3.5	Yes	No	0	9	4
222	R:R:C280	R:R:I309	3.27	No	No	0	5	7
223	R:R:R288	R:R:W284	10	Yes	Yes	1	8	8
224	R:R:W284	R:R:W297	5.62	Yes	Yes	1	8	8
225	R:R:I309	R:R:W284	9.4	No	Yes	0	7	8
226	R:R:T286	R:R:Y290	3.75	No	No	0	4	3
227	R:R:F291	R:R:L287	3.65	No	No	0	3	4
228	R:R:L287	R:R:L305	8.3	No	Yes	0	4	2
229	R:R:R288	R:R:W297	22.99	Yes	Yes	1	8	8
230	R:R:N300	R:R:R288	6.03	No	Yes	0	6	8
231	R:R:L305	R:R:R288	4.86	Yes	Yes	1	2	8
232	R:R:D293	R:R:L289	4.07	No	No	1	6	3
233	R:R:L289	R:R:W297	4.56	No	Yes	1	3	8
234	R:R:D292	R:R:F291	3.58	No	No	0	5	3
235	R:R:D292	R:R:S302	5.89	No	No	1	5	5
236	R:R:D292	R:R:L305	4.07	No	Yes	1	5	2
237	R:R:D293	R:R:W297	7.82	No	Yes	1	6	8
238	R:R:C296	R:R:D298	7.78	No	Yes	0	9	6
239	R:R:N300	R:R:W306	9.04	No	Yes	0	6	5
240	R:R:L305	R:R:S302	7.51	Yes	No	1	2	5
241	R:R:T303	R:R:W307	8.49	No	No	0	6	6
242	R:R:I309	R:R:W306	5.87	No	Yes	0	7	5
243	R:R:K310	R:R:W306	11.6	No	Yes	0	6	5
244	R:R:E374	R:R:W306	4.36	No	Yes	0	4	5
245	R:R:K310	R:R:W307	9.28	No	No	0	6	6
246	R:R:G311	R:R:P312	4.06	No	No	0	4	9
247	R:R:I317	R:R:Y366	6.04	Yes	Yes	1	7	8
248	R:R:I317	R:R:T367	3.04	Yes	No	0	7	6
249	R:R:F362	R:R:N320	9.67	Yes	No	0	9	9
250	R:R:F321	R:R:I325	7.54	No	No	0	6	5
251	R:R:F324	R:R:I325	3.77	Yes	No	0	9	5
252	R:R:F324	R:R:I328	7.54	Yes	No	0	9	7
253	R:R:F324	R:R:L358	4.87	Yes	No	8	9	9
254	R:R:F324	R:R:F362	5.36	Yes	Yes	8	9	9
255	R:R:F324	R:R:I364	8.79	Yes	No	0	9	6
256	R:R:I328	R:R:T355	3.04	No	No	0	7	9
257	R:R:L357	R:R:R353	6.07	No	No	0	8	8
258	R:R:I359	R:R:T355	3.04	No	No	0	8	9
259	R:R:L357	R:R:L399	8.3	No	No	0	8	8
260	R:R:F362	R:R:L358	8.53	Yes	No	8	9	9
261	R:R:I359	R:R:P360	3.39	No	No	0	8	9
262	R:R:I359	R:R:I364	10.3	No	No	0	8	6
263	R:R:P360	R:R:V395	5.3	No	No	0	9	6
264	R:R:F362	R:R:L361	7.31	Yes	No	0	9	9
265	R:R:L361	R:R:Y400	16.41	No	No	0	9	9
266	R:R:G363	R:R:H365	3.18	No	No	0	9	9
267	R:R:H365	R:R:Y366	22.87	No	Yes	1	9	8
268	R:R:H365	R:R:Q392	4.95	No	No	1	9	9
269	R:R:E385	R:R:Y366	4.49	Yes	Yes	1	8	8
270	R:R:Q392	R:R:Y366	3.38	No	Yes	1	9	8
271	R:R:E380	R:R:F369	7	No	Yes	0	5	6
272	R:R:F369	R:R:R381	4.28	Yes	No	1	6	7
273	R:R:F369	R:R:F384	7.5	Yes	No	1	6	3
274	R:R:E385	R:R:F369	3.5	Yes	Yes	1	8	6
275	R:R:P373	R:R:S372	3.56	No	No	10	8	5
276	R:R:S372	R:R:V376	3.23	No	No	10	5	4
277	R:R:P373	R:R:V376	12.37	No	No	10	8	4
278	R:R:S377	R:R:V376	3.23	No	No	0	5	4
279	R:R:E380	R:R:S377	7.19	No	No	0	5	5
280	R:R:E385	R:R:R381	20.93	Yes	No	1	8	7
281	R:R:C401	R:R:F402	6.98	No	No	0	9	8
282	R:R:E406	R:R:N404	13.15	No	No	0	9	9
283	R:R:N404	R:R:V407	7.39	No	No	0	9	9
284	R:R:G405	R:R:Q408	3.29	No	No	0	5	7
285	R:R:I411	R:R:W415	10.57	No	No	0	5	5
286	R:R:K414	R:R:R413	8.66	No	No	0	5	7
287	R:R:L331	R:R:S354	3	No	No	0	9	9
288	R:R:N117	R:R:S124	2.98	No	No	0	4	6
289	R:R:Y265	R:R:Y269	2.98	Yes	Yes	0	4	7
290	R:R:L323	R:R:V319	2.98	No	No	0	8	6
291	R:R:I246	R:R:I272	2.94	Yes	No	0	8	6
292	R:R:I26	R:R:K29	2.91	No	No	0	5	5
293	R:R:F242	R:R:P312	2.89	No	No	0	5	9
294	R:R:I328	R:R:L351	2.85	No	No	0	7	9
295	R:R:L165	R:R:M197	2.83	No	No	0	7	7
296	R:R:L168	R:R:M197	2.83	Yes	No	0	9	7
297	R:R:E120	R:R:T119	2.82	No	No	0	1	6
298	R:R:G56	R:R:W123	2.81	Yes	Yes	2	5	9
299	R:R:G273	R:R:W243	2.81	No	Yes	0	9	9
300	R:R:W415	R:R:W418	2.81	No	No	0	5	4
301	R:R:M72	R:R:N117	2.8	No	No	0	4	4
302	R:R:L175	R:R:L181	2.77	Yes	Yes	0	8	9
303	R:R:L331	R:R:L351	2.77	No	No	0	9	9
304	L:L:L137	R:R:Q146	2.66	No	No	0	5	1
305	R:R:L403	R:R:Q408	2.66	No	No	0	7	7
306	L:L:V143	R:R:F27	2.62	No	No	0	6	6
307	R:R:F369	R:R:V368	2.62	Yes	No	1	6	6
308	R:R:F384	R:R:V368	2.62	No	No	1	3	6
309	R:R:F394	R:R:V398	2.62	No	No	0	5	5
310	R:R:D145	R:R:Q146	2.61	No	No	0	1	1
311	R:R:V114	R:R:Y130	2.52	No	No	0	6	8
312	R:R:V281	R:R:Y235	2.52	No	Yes	0	7	9
313	R:R:V396	R:R:Y400	2.52	No	No	0	9	9
314	R:R:F252	R:R:I327	2.51	No	Yes	0	7	9
315	R:R:F362	R:R:I327	2.51	Yes	Yes	0	9	9
316	R:R:T158	R:R:Y157	2.5	No	Yes	0	7	8
317	R:R:F193	R:R:M172	2.49	No	No	0	8	6
318	R:R:F371	R:R:M318	2.49	No	No	0	4	4
319	R:R:E71	R:R:H68	2.46	No	No	0	3	2
320	R:R:V194	R:R:W274	2.45	No	Yes	0	4	8
321	L:L:Y146	R:R:K28	2.39	Yes	No	0	8	3
322	R:R:I209	R:R:W208	2.35	No	No	0	5	4
323	R:R:L399	R:R:Y400	2.34	No	No	0	8	9
324	R:R:E79	R:R:R82	2.33	No	No	0	2	4
325	R:R:Q31	R:R:W58	2.19	No	No	0	4	7
326	L:L:Y146	R:R:F27	2.06	Yes	No	0	8	6
327	R:R:F204	R:R:Y161	2.06	No	Yes	0	7	7
328	R:R:F291	R:R:Y290	2.06	No	No	0	3	3
329	R:R:G53	R:R:P55	2.03	No	No	0	1	4
330	R:R:G56	R:R:P55	2.03	Yes	No	0	5	4
331	R:R:G275	R:R:P277	2.03	No	Yes	0	7	9
332	R:R:R264	R:R:W268	2	No	No	0	5	3
333	R:R:C118	R:R:G70	1.96	No	No	0	9	7
334	R:R:W268	R:R:Y265	1.93	No	Yes	0	3	4
335	R:R:C77	R:R:P78	1.88	No	No	0	9	9
336	R:R:G160	R:R:S390	1.86	No	No	0	9	9
337	R:R:G53	R:R:V69	1.84	No	No	0	1	6
338	R:R:G70	R:R:V69	1.84	No	No	0	7	6
339	R:R:G112	R:R:V113	1.84	No	No	0	6	1
340	R:R:G160	R:R:V159	1.84	No	No	0	9	6
341	R:R:G311	R:R:V314	1.84	No	No	0	4	4
342	R:R:G315	R:R:V314	1.84	No	No	0	4	4
343	R:R:G326	R:R:V329	1.84	No	No	0	8	8
344	R:R:G122	R:R:T119	1.82	No	No	0	9	6
345	R:R:P338	R:R:S337	1.78	No	No	0	6	7
346	R:R:G112	R:R:M111	1.75	No	No	0	6	3
347	R:R:C134	R:R:V113	1.71	No	No	0	9	1
348	R:R:C134	R:R:V114	1.71	No	No	0	9	6
349	R:R:G387	R:R:L386	1.71	No	Yes	0	5	8
350	R:R:A67	R:R:V73	1.7	No	No	0	8	8
351	R:R:A133	R:R:V113	1.7	No	No	0	6	1
352	R:R:G405	R:R:N404	1.7	No	No	0	5	9
353	R:R:D145	R:R:G144	1.68	No	No	0	1	1
354	R:R:K65	R:R:P66	1.67	No	No	0	7	4
355	R:R:C226	R:R:I209	1.64	No	No	0	9	5
356	R:R:L254	R:R:P261	1.64	No	No	0	7	7
357	R:R:C176	R:R:M172	1.62	No	No	0	4	6
358	R:R:A32	R:R:K29	1.61	No	No	0	2	5
359	R:R:A41	R:R:K37	1.61	No	No	0	4	4
360	R:R:S124	R:R:T119	1.6	No	No	0	6	6
361	R:R:V279	R:R:V283	1.6	No	No	0	4	4
362	R:R:V283	R:R:V308	1.6	No	No	0	4	8
363	R:R:V329	R:R:V332	1.6	No	No	0	8	6
364	R:R:T282	R:R:V281	1.59	No	No	0	3	7
365	R:R:T282	R:R:V283	1.59	No	No	0	3	4
366	R:R:E125	R:R:P126	1.57	No	No	0	4	5
367	R:R:C34	R:R:D59	1.56	No	Yes	2	9	9
368	R:R:C63	R:R:D59	1.56	No	Yes	2	9	9
369	R:R:I330	R:R:V329	1.54	Yes	No	0	8	8
370	R:R:K227	R:R:S222	1.53	No	No	0	7	6
371	R:R:A32	R:R:Q31	1.52	No	No	0	2	4
372	R:R:F81	R:R:G135	1.51	Yes	No	0	6	3
373	R:R:L74	R:R:S115	1.5	No	No	0	4	5
374	L:L:N148	L:L:S149	1.49	No	No	0	7	8
375	R:R:I201	R:R:I205	1.47	No	No	0	4	6
376	R:R:D301	R:R:S302	1.47	No	No	0	4	5
377	R:R:I317	R:R:M318	1.46	Yes	No	0	7	4
378	R:R:I330	R:R:K334	1.45	Yes	No	0	8	9
379	R:R:K29	R:R:M33	1.44	No	No	0	5	4
380	R:R:F127	R:R:P128	1.44	No	No	0	3	4
381	R:R:I38	R:R:L35	1.43	No	No	0	6	2
382	R:R:I347	R:R:L335	1.43	No	No	0	7	8
383	R:R:E225	R:R:T223	1.41	No	No	0	5	3
384	R:R:C176	R:R:R177	1.39	No	No	0	4	3
385	R:R:L331	R:R:L335	1.38	No	No	0	9	8
386	R:R:I330	R:R:Q333	1.37	Yes	No	0	8	7
387	R:R:M111	R:R:Q88	1.36	No	No	0	3	3
388	R:R:E30	R:R:L80	1.33	No	No	0	7	5
389	R:R:A285	R:R:W297	1.3	No	Yes	0	5	8
390	R:R:R288	R:R:T294	1.29	Yes	No	0	8	3
391	R:R:Q333	R:R:Q336	1.28	No	No	0	7	7
392	R:R:D132	R:R:H129	1.26	No	No	0	6	2
393	R:R:F178	R:R:I411	1.26	Yes	No	0	6	5
394	L:L:K145	L:L:Y146	1.19	No	Yes	0	9	8
395	L:L:Y134	R:R:L151	1.17	Yes	No	0	8	2
396	R:R:R350	R:R:R353	1.07	No	No	0	8	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:H125	7.14333	6	1	9
2	L:L:D127	5.62833	6	1	9
3	L:L:F130	5.1075	4	1	9
4	L:L:Y134	5.13167	6	1	8
5	L:L:Y146	5.0375	4	0	8
6	R:R:G56	3.615	4	2	5
7	R:R:D59	4.088	5	2	9
8	R:R:W64	10.775	6	2	9
9	R:R:F81	5.614	5	4	6
10	R:R:R116	11.04	4	2	9
11	R:R:W123	8.27833	6	2	9
12	R:R:Y149	9.442	5	0	4
13	R:R:Y150	6.136	5	1	4
14	R:R:Y157	5.895	8	1	8
15	R:R:Y161	4.76857	7	1	7
16	R:R:L168	3.926	5	0	9
17	R:R:L175	3.9275	4	0	8
18	R:R:F178	7.495	4	6	6
19	R:R:L181	6.34	4	6	9
20	R:R:F196	7.8175	4	0	8
21	R:R:R199	7.51667	6	1	8
22	R:R:V203	4.1125	4	1	7
23	R:R:K206	6.865	4	0	6
24	R:R:D207	5.3525	4	1	7
25	R:R:Y211	9.722	5	1	4
26	R:R:F233	6.22571	7	1	6
27	R:R:H234	6.435	4	1	7
28	R:R:Y235	4.51	4	0	9
29	R:R:N240	8.9275	4	0	9
30	R:R:Y241	7.242	5	1	7
31	R:R:W243	8.54667	6	0	9
32	R:R:F245	4.7875	4	0	8
33	R:R:I246	4.37	4	0	8
34	R:R:Y265	7.2375	4	0	4
35	R:R:Y269	5.232	5	0	7
36	R:R:W274	7.102	5	0	8
37	R:R:P277	4.635	4	0	9
38	R:R:W284	7.5775	4	1	8
39	R:R:R288	9.034	5	1	8
40	R:R:W297	9.94833	6	1	8
41	R:R:D298	8.515	4	0	6
42	R:R:L305	6.185	4	1	2
43	R:R:W306	6.32167	6	0	5
44	R:R:I317	3.845	4	1	7
45	R:R:F324	6.066	5	8	9
46	R:R:I327	4.11	4	0	9
47	R:R:I330	2.16	4	0	8
48	R:R:F362	6.31667	6	8	9
49	R:R:Y366	9.45833	6	1	8
50	R:R:F369	4.98	5	1	6
51	R:R:E385	9.0275	4	1	8
52	R:R:L386	6.148	5	1	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:D127	L:L:H125	10.2276	3.78	Yes	Yes	1	9	9
2	L:L:H125	R:R:H234	22.3053	5.97	Yes	Yes	1	9	7
3	L:L:D127	R:R:F233	35.0122	4.78	Yes	Yes	1	9	6
4	R:R:F233	R:R:H234	28.2906	11.31	Yes	Yes	1	6	7
5	L:L:D127	R:R:R199	38.9952	11.91	Yes	Yes	1	9	8
6	R:R:R199	R:R:V237	37.965	9.15	Yes	No	1	8	6
7	R:R:F233	R:R:V237	29.9556	3.93	Yes	No	1	6	6
8	L:L:H125	R:R:Y241	12.4041	3.27	Yes	Yes	1	9	7
9	R:R:H234	R:R:W306	13.8424	3.17	Yes	Yes	0	7	5
10	R:R:F233	R:R:M230	59.8603	3.73	Yes	No	0	6	6
11	R:R:D298	R:R:M230	59.3199	6.93	Yes	No	0	6	6
12	L:L:T135	R:R:D298	60.0526	5.78	No	Yes	0	9	6
13	L:L:T135	R:R:M299	59.3851	3.01	No	No	0	9	5
14	L:L:R136	R:R:M299	57.9088	6.2	No	No	3	9	5
15	L:L:Q140	L:L:R136	57.361	3.5	No	No	3	7	9
16	L:L:Q140	R:R:F84	55.0576	22.25	No	No	3	7	5
17	L:L:K144	R:R:F84	54.6114	16.13	No	No	0	8	5
18	L:L:K144	R:R:F81	53.8968	3.72	No	Yes	0	8	6
19	R:R:C77	R:R:F81	50.3491	4.19	No	Yes	0	9	6
20	R:R:C134	R:R:C77	23.1033	7.28	No	No	0	9	9
21	R:R:C134	R:R:V113	17.1107	1.71	No	No	0	9	1
22	R:R:G112	R:R:V113	15.3659	1.84	No	No	0	6	1
23	R:R:G112	R:R:S76	12.7215	3.71	No	No	0	6	4
24	R:R:D110	R:R:S76	11.8328	8.83	No	No	0	4	4
25	R:R:D110	R:R:R82	10.9404	3.57	No	No	0	4	4
26	R:R:E79	R:R:R82	10.0444	2.33	No	No	0	2	4
27	R:R:C77	R:R:P78	29.747	1.88	No	No	0	9	9
28	R:R:P78	R:R:T62	28.9254	3.5	No	No	0	9	5
29	R:R:T62	R:R:W64	22.8494	7.28	No	Yes	2	5	9
30	R:R:W123	R:R:W64	16.9421	12.18	Yes	Yes	2	9	9
31	R:R:G56	R:R:W123	11.8527	2.81	Yes	Yes	2	5	9
32	R:R:N240	R:R:R199	100	9.64	Yes	Yes	0	9	8
33	R:R:F196	R:R:N240	19.5629	14.5	Yes	Yes	0	8	9
34	R:R:F196	R:R:L168	19.1149	3.65	Yes	Yes	0	8	9
35	R:R:N240	R:R:S195	88.3504	7.45	Yes	No	0	9	9
36	R:R:S195	R:R:W243	87.7174	4.94	No	Yes	0	9	9
37	R:R:I188	R:R:W243	63.7236	4.7	No	Yes	0	9	9
38	R:R:E247	R:R:I188	61.0719	6.83	No	No	0	9	9
39	R:R:E247	R:R:H189	28.3323	7.39	No	No	0	9	9
40	R:R:H189	R:R:R185	27.3293	6.77	No	No	0	9	9
41	R:R:N186	R:R:R185	25.2689	8.44	No	No	5	9	9
42	R:R:L175	R:R:N186	24.2985	4.12	Yes	No	0	8	9
43	R:R:L175	R:R:L181	17.0998	2.77	Yes	Yes	0	8	9
44	R:R:I246	R:R:W243	27.3801	3.52	Yes	Yes	0	8	9
45	R:R:I246	R:R:Y269	19.1004	7.25	Yes	Yes	0	8	7
46	R:R:H234	R:R:W284	36.066	5.29	Yes	Yes	1	7	8
47	R:R:W284	R:R:W297	12.7578	5.62	Yes	Yes	1	8	8
48	R:R:W243	R:R:W274	15.8955	20.62	Yes	Yes	0	9	8
49	R:R:W274	R:R:Y235	13.8279	3.86	Yes	Yes	0	8	9
50	R:R:C280	R:R:I309	16.0787	3.27	No	No	0	5	7
51	R:R:C280	R:R:V238	14.8454	5.12	No	No	0	5	6
52	R:R:P277	R:R:V238	14.2342	8.84	Yes	No	0	9	6
53	R:R:P277	R:R:Y235	11.6659	4.17	Yes	Yes	0	9	9
54	R:R:E247	R:R:L361	35.5945	5.3	No	No	0	9	9
55	R:R:F362	R:R:L361	28.8057	7.31	Yes	No	0	9	9
56	R:R:F362	R:R:I327	10.7518	2.51	Yes	Yes	0	9	9
57	R:R:Y265	R:R:Y269	12.1683	2.98	Yes	Yes	0	4	7
58	R:R:R288	R:R:W284	21.5979	10	Yes	Yes	1	8	8
59	R:R:L305	R:R:R288	18.9916	4.86	Yes	Yes	1	2	8
60	R:R:F324	R:R:F362	14.9796	5.36	Yes	Yes	8	9	9
61	R:R:R199	R:R:Y161	12.8575	5.14	Yes	Yes	1	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:H125	R:R:F233	4.53	1	Yes	Yes	9	6	0	1
L:L:H125	R:R:H234	5.97	1	Yes	Yes	9	7	0	1
L:L:H125	R:R:V237	17.99	1	Yes	No	9	6	0	1
L:L:H125	R:R:Y241	3.27	1	Yes	Yes	9	7	0	1
L:L:S126	R:R:E385	7.19	1	No	Yes	9	8	0	1
L:L:S126	R:R:L386	6.01	1	No	Yes	9	8	0	1
L:L:D127	R:R:Y161	3.45	1	Yes	Yes	9	7	0	1
L:L:D127	R:R:R199	11.91	1	Yes	Yes	9	8	0	1
L:L:D127	R:R:F233	4.78	1	Yes	Yes	9	6	0	1
L:L:D127	R:R:L386	5.43	1	Yes	Yes	9	8	0	1
L:L:A128	R:R:W306	3.89	0	No	Yes	8	5	0	1
L:L:V129	R:R:E374	5.7	0	No	No	7	4	0	1
L:L:V129	R:R:R381	6.54	0	No	No	7	7	0	1
L:L:V129	R:R:L382	5.96	0	No	No	7	5	0	1
L:L:F130	R:R:Y150	6.19	1	Yes	Yes	9	4	0	1
L:L:F130	R:R:V153	3.93	1	Yes	No	9	6	0	1
L:L:F130	R:R:Y157	7.22	1	Yes	Yes	9	8	0	1
L:L:T131	R:R:K206	9.01	0	No	Yes	9	6	0	1
L:L:D132	R:R:M299	5.54	3	No	No	9	5	0	1
L:L:N133	R:R:Y150	5.81	1	No	Yes	8	4	0	1
L:L:N133	R:R:K378	6.99	1	No	No	8	5	0	1
L:L:N133	R:R:L382	4.12	1	No	No	8	5	0	1
L:L:Y134	R:R:D147	3.45	1	Yes	No	8	1	0	1
L:L:Y134	R:R:Y150	3.97	1	Yes	Yes	8	4	0	1
L:L:Y134	R:R:Y211	11.91	1	Yes	Yes	8	4	0	1
L:L:T135	R:R:D298	5.78	0	No	Yes	9	6	0	1
L:L:T135	R:R:M299	3.01	0	No	No	9	5	0	1
L:L:R136	R:R:M299	6.2	3	No	No	9	5	0	1
L:L:L137	R:R:D147	4.07	0	No	No	5	1	0	1
L:L:R138	R:R:Y211	14.4	1	No	Yes	8	4	0	1
L:L:K139	R:R:I83	5.82	0	No	No	8	4	0	1
L:L:Q140	R:R:I83	12.35	3	No	No	7	4	0	1
L:L:Q140	R:R:F84	22.25	3	No	No	7	5	0	1
L:L:M141	R:R:D147	5.54	0	No	No	8	1	0	1
L:L:K144	R:R:F81	3.72	0	No	Yes	8	6	0	1
L:L:K144	R:R:F84	16.13	0	No	No	8	5	0	1
L:L:L147	R:R:F81	3.65	4	No	Yes	9	6	0	1
L:L:L147	R:R:F131	6.09	4	No	No	9	4	0	1
L:L:I150	R:R:N60	4.25	0	No	No	6	6	0	1
R:R:C25	R:R:K28	4.85	0	No	No	4	3	2	1
R:R:F27	R:R:L80	3.65	0	No	No	6	5	1	2
R:R:F131	R:R:I61	20.09	4	No	No	4	4	1	2
R:R:C77	R:R:F81	4.19	0	No	Yes	9	6	2	1
R:R:F131	R:R:F81	15	4	No	Yes	4	6	1	1
R:R:F84	R:R:I83	5.02	3	No	No	5	4	1	1
R:R:Y149	R:R:Y150	9.93	0	Yes	Yes	4	4	2	1
R:R:V153	R:R:Y149	6.31	0	No	Yes	6	4	1	2
R:R:L382	R:R:Y149	3.52	0	No	Yes	5	4	1	2
R:R:K378	R:R:Y150	4.78	1	No	Yes	5	4	1	1
R:R:K154	R:R:Y157	4.78	0	No	Yes	5	8	2	1
R:R:K154	R:R:Y211	7.17	0	No	Yes	5	4	2	1
R:R:Y157	R:R:Y161	3.97	1	Yes	Yes	8	7	1	1
R:R:V203	R:R:Y157	5.05	1	Yes	Yes	7	8	2	1
R:R:D207	R:R:Y157	5.75	1	Yes	Yes	7	8	2	1
R:R:L386	R:R:Y157	14.07	1	Yes	Yes	8	8	1	1
R:R:S390	R:R:Y157	3.82	1	No	Yes	9	8	2	1
R:R:R199	R:R:Y161	5.14	1	Yes	Yes	8	7	1	1
R:R:V203	R:R:Y161	3.79	1	Yes	Yes	7	7	2	1
R:R:L386	R:R:Y161	3.52	1	Yes	Yes	8	7	1	1
R:R:S390	R:R:Y161	11.45	1	No	Yes	9	7	2	1
R:R:R199	R:R:V237	9.15	1	Yes	No	8	6	1	1
R:R:N240	R:R:R199	9.64	0	Yes	Yes	9	8	2	1
R:R:R199	R:R:Y241	6.17	1	Yes	Yes	8	7	1	1
R:R:R199	R:R:Y366	3.09	1	Yes	Yes	8	8	1	2
R:R:S202	R:R:V203	3.23	0	No	Yes	6	7	2	2
R:R:F233	R:R:S202	6.61	1	Yes	No	6	6	1	2
R:R:D207	R:R:V203	4.38	1	Yes	Yes	7	7	2	2
R:R:D207	R:R:K206	5.53	1	Yes	Yes	7	6	2	1
R:R:K206	R:R:L210	4.23	0	Yes	No	6	7	1	2
R:R:F233	R:R:K206	8.69	1	Yes	Yes	6	6	1	1
R:R:D207	R:R:Y211	5.75	1	Yes	Yes	7	4	2	1
R:R:L210	R:R:Y211	9.38	0	No	Yes	7	4	2	1
R:R:D298	R:R:L210	13.57	0	Yes	No	6	7	1	2
R:R:F233	R:R:M230	3.73	1	Yes	No	6	6	1	2
R:R:D298	R:R:M230	6.93	0	Yes	No	6	6	1	2
R:R:F233	R:R:H234	11.31	1	Yes	Yes	6	7	1	1
R:R:F233	R:R:V237	3.93	1	Yes	No	6	6	1	1
R:R:H234	R:R:W284	5.29	1	Yes	Yes	7	8	1	2
R:R:H234	R:R:W306	3.17	1	Yes	Yes	7	5	1	1
R:R:V313	R:R:Y241	5.05	0	No	Yes	7	7	2	1
R:R:I317	R:R:Y241	4.84	1	Yes	Yes	7	7	2	1
R:R:Y241	R:R:Y366	16.88	1	Yes	Yes	7	8	1	2
R:R:I309	R:R:W284	9.4	0	No	Yes	7	8	2	2
R:R:C296	R:R:D298	7.78	0	No	Yes	9	6	2	1
R:R:N300	R:R:W306	9.04	0	No	Yes	6	5	2	1
R:R:I309	R:R:W306	5.87	0	No	Yes	7	5	2	1
R:R:K310	R:R:W306	11.6	0	No	Yes	6	5	2	1
R:R:E374	R:R:W306	4.36	0	No	Yes	4	5	1	1
R:R:I317	R:R:Y366	6.04	1	Yes	Yes	7	8	2	2
R:R:E385	R:R:Y366	4.49	1	Yes	Yes	8	8	1	2
R:R:F369	R:R:R381	4.28	1	Yes	No	6	7	2	1
R:R:E385	R:R:F369	3.5	1	Yes	Yes	8	6	1	2
R:R:E385	R:R:R381	20.93	1	Yes	No	8	7	1	1
L:L:L137	R:R:Q146	2.66	0	No	No	5	1	0	1
L:L:V143	R:R:F27	2.62	0	No	No	6	6	0	1
R:R:D145	R:R:Q146	2.61	0	No	No	1	1	2	1
R:R:T158	R:R:Y157	2.5	0	No	Yes	7	8	2	1
L:L:Y146	R:R:K28	2.39	0	Yes	No	8	3	0	1
L:L:Y146	R:R:F27	2.06	0	Yes	No	8	6	0	1
R:R:F204	R:R:Y161	2.06	0	No	Yes	7	7	2	1
R:R:G387	R:R:L386	1.71	0	No	Yes	5	8	2	1
R:R:F81	R:R:G135	1.51	4	Yes	No	6	3	1	2
L:L:Y134	R:R:L151	1.17	1	Yes	No	8	2	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9P93_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.01
Number of Linked Nodes	342
Number of Links	396
Number of Hubs	52
Number of Links mediated by Hubs	194
Number of Communities	10
Number of Nodes involved in Communities	78
Number of Links involved in Communities	109

Path Summary
Number Of Nodes in MetaPath	62
Number Of Links MetaPath	61
Number of Shortest Paths	99235
Length Of Smallest Path	3
Average Path Length	16.0838
Length of Longest Path	40
Minimum Path Strength	1.325
Average Path Strength	6.47565
Maximum Path Strength	20.195
Minimum Path Correlation	0.7
Average Path Correlation	0.967112
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.94118
Average % Of Corr. Nodes	65.9211
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.9397
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • vasoactive intestinal polypeptide receptor binding • signaling receptor binding • type 2 vasoactive intestinal polypeptide receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • hormone activity • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • neuropeptide hormone activity • neuropeptide activity • peptide hormone receptor binding • hormone receptor binding • type 1 vasoactive intestinal polypeptide receptor binding • body fluid secretion • localization • regulation of body fluid levels • secretion • transport • regulation of biological quality • establishment of localization • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • establishment of protein localization • nitrogen compound transport • hormone secretion • protein localization to extracellular region • peptide secretion • secretion by cell • signal release • intracellular protein localization • regulation of hormone levels • prolactin secretion • establishment of protein localization to extracellular region • cell-cell signaling • export from cell • protein secretion • peptide transport • protein transport • peptide hormone secretion • macromolecule localization • hormone transport • regulation of localization • regulation of protein localization • monoamine transport • epinephrine secretion • organic hydroxy compound transport • organic cation transport • catecholamine secretion • catecholamine transport • epinephrine transport • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of cAMP/PKA signal transduction • positive regulation of response to stimulus • cAMP/PKA signal transduction • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of intracellular signal transduction • regulation of cAMP/PKA signal transduction • regulation of response to stimulus • regulation of cell communication • positive regulation of signaling • catabolic process • positive regulation of protein metabolic process • macromolecule catabolic process • regulation of primary metabolic process • positive regulation of metabolic process • positive regulation of macromolecule metabolic process • protein metabolic process • regulation of protein metabolic process • primary metabolic process • regulation of macromolecule metabolic process • protein catabolic process • regulation of catabolic process • positive regulation of protein catabolic process • positive regulation of catabolic process • metabolic process • macromolecule metabolic process • regulation of metabolic process • regulation of protein catabolic process • negative regulation of biological process • positive regulation of macromolecule biosynthetic process • nucleobase-containing compound metabolic process • post-transcriptional regulation of gene expression • regulation of RNA metabolic process • negative regulation of nucleobase-containing compound metabolic process • regulation of nucleobase-containing compound metabolic process • RNA catabolic process • mRNA stabilization • mRNA catabolic process • negative regulation of metabolic process • nucleobase-containing compound catabolic process • regulation of gene expression • negative regulation of gene expression • biosynthetic process • negative regulation of macromolecule biosynthetic process • nucleic acid catabolic process • regulation of macromolecule biosynthetic process • negative regulation of RNA metabolic process • RNA metabolic process • negative regulation of mRNA metabolic process • regulation of mRNA catabolic process • positive regulation of biosynthetic process • negative regulation of cellular process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • negative regulation of catabolic process • negative regulation of mRNA catabolic process • negative regulation of RNA catabolic process • gene expression • mRNA metabolic process • macromolecule biosynthetic process • nucleic acid metabolic process • regulation of mRNA stability • RNA stabilization • negative regulation of biosynthetic process • positive regulation of gene expression • regulation of RNA stability • regulation of mRNA metabolic process • small GTPase binding • enzyme binding • GTPase binding • molecular transducer activity • signaling receptor activity • adenylate cyclase binding • vasoactive intestinal polypeptide receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • neuropeptide binding • peptide binding • peptide hormone binding • hormone binding • peptide receptor activity • G protein-coupled peptide receptor activity • pituitary adenylate cyclase-activating polypeptide receptor activity • response to xenobiotic stimulus • developmental process • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • cellular developmental process • cell differentiation • multicellular organismal process • response to stress • multicellular organismal response to stress • response to ethanol • cell surface receptor signaling pathway • regulation of calcium ion transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • cellular localization • regulation of calcium ion transport into cytosol • monoatomic ion transmembrane transport • regulation of monoatomic ion transmembrane transport • calcium ion transport • metal ion transport • monoatomic cation transmembrane transport • regulation of calcium ion transmembrane transport • positive regulation of monoatomic ion transport • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation transport • regulation of metal ion transport • calcium ion transmembrane import into cytosol • regulation of transport • regulation of monoatomic ion transport • positive regulation of cytosolic calcium ion concentration • transmembrane transport • positive regulation of calcium ion transport into cytosol • regulation of transmembrane transport • positive regulation of transport • regulation of cellular localization • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • calcium ion transport into cytosol • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • positive regulation of small GTPase mediated signal transduction • multicellular organism development • development of primary sexual characteristics • sex differentiation • anatomical structure development • female sex differentiation • development of primary female sexual characteristics • regulation of inositol phosphate biosynthetic process • alcohol metabolic process • positive regulation of phosphate metabolic process • inositol phosphate metabolic process • regulation of small molecule metabolic process • phosphate-containing compound metabolic process • polyol biosynthetic process • small molecule metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • carbohydrate metabolic process • polyol metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • carbohydrate biosynthetic process • positive regulation of inositol phosphate biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • response to estradiol • negative regulation of response to reactive oxygen species • negative regulation of response to stimulus • response to reactive oxygen species • response to oxidative stress • regulation of response to reactive oxygen species • regulation of response to stress • regulation of response to oxidative stress • negative regulation of response to oxidative stress • cell surface • membrane microdomain • membrane raft • plasma membrane raft • plasma membrane region • caveola • receptor complex • endosome • intracellular vesicle • endomembrane system • cytoplasmic vesicle • cell-cell junction • apical junction complex • bicellular tight junction • tight junction • anchoring junction • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • system process • nervous system process • neuromuscular process • regulation of system process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • sensory perception of chemical stimulus • sensory perception • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • system development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of establishment of protein localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • regulation of peptide hormone secretion • positive regulation of peptide hormone secretion • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • regulation of hormone secretion • regulation of peptide secretion • positive regulation of secretion by cell • positive regulation of protein transport • regulation of secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of peptide secretion • regulation of peptide transport • regulation of establishment of protein localization • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • response to hexose • regulation of insulin secretion • regulation of insulin secretion involved in cellular response to glucose stimulus • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • FnI-like domain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • FnI-like domain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	L
Protein	VIP
UniProt	P01282
Sequence	>9P93_nogp_Chain_L H S D A V F T D N Y T R L R K Q M A V K K Y L N S I L N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P41586
Sequence	>9P93_nogp_Chain_R D C I F K K E Q A M C L E K I Q R A G C P G M W D N I T C W K P A H V G E M V L V S C P E L F R I F N P D Q D M G V V S R N C T E D G W S E P F P H Y F D A C G T G D Q D Y Y Y L S V K A L Y T V G Y S T S L V T L T T A M V I L C R F R K L H C T R N F I H M N L F V S F M L R A I S V F I K D W I L Y S T V E C K A V M V F F H Y C V V S N Y F W L F I E G L Y L F T L L V E T F F P E R R Y F Y W Y T I I G W G T P T V C V T V W A T L R L Y F D D T G C W D M N D S T A L W W V I K G P V V G S I M V N F V L F I G I I V I L V Q K L Q S P I Y L R L A R S T L L L I P L F G I H Y T V F A F S P E N V S K R E R L V F E L G L G S F Q G F V V A V L Y C F L N G E V Q A E I K R K W R S W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6P9Y	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-	Gs/β1/γ2	3.01	2020-02-05	doi.org/10.1016/j.molcel.2020.01.012
	6P9Y (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-		3.01	2020-02-05	doi.org/10.1016/j.molcel.2020.01.012
	6LPB	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-	Gs/β1/γ1	3.9	2020-03-11	doi.org/10.1038/s41594-020-0386-8
	6LPB (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-		3.9	2020-03-11	doi.org/10.1038/s41594-020-0386-8
	6M1H	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	Maxadilan	-	Gs/β1/γ2	3.6	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	6M1H (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	Maxadilan	-		3.6	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	6M1I	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-	Gs/β1/γ2	3.5	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	6M1I (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-		3.5	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	8E3X	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-	Gs/β1/γ2	2.3	2022-11-23	doi.org/10.1038/s41467-022-34629-3
	8E3X (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-		2.3	2022-11-23	doi.org/10.1038/s41467-022-34629-3
	9P92	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	VIP	-	Gs/β1/γ2	3.8	2025-11-19	10.1073/pnas.2521157122
	9P92 (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	VIP	-		3.8	2025-11-19	10.1073/pnas.2521157122
	9P93	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	VIP	-	Gs/β1/γ2	3.2	2025-11-19	10.1073/pnas.2521157122
	9P93 (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	VIP	-		3.2	2025-11-19	10.1073/pnas.2521157122
	9P94	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-	Gs/β1/γ2	3	2025-11-19	10.1073/pnas.2521157122
	9P94 (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-		3	2025-11-19	10.1073/pnas.2521157122

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