psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:G135	L:L:H132	4.77	No	Yes	0	9	9
2	L:L:H132	R:R:V237	15.22	Yes	Yes	0	9	6
3	L:L:H132	R:R:Y241	5.44	Yes	Yes	0	9	7
4	L:L:H132	R:R:W306	6.35	Yes	Yes	0	9	5
5	L:L:S133	R:R:E385	7.19	No	No	0	9	8
6	L:L:S133	R:R:L386	4.5	No	No	0	9	8
7	L:L:D134	R:R:Y161	6.9	Yes	Yes	1	9	7
8	L:L:D134	R:R:R199	10.72	Yes	Yes	1	9	8
9	L:L:D134	R:R:F233	5.97	Yes	Yes	1	9	6
10	L:L:D134	R:R:V237	4.38	Yes	Yes	1	9	6
11	L:L:I136	R:R:E374	12.3	No	Yes	0	9	4
12	L:L:I136	R:R:K378	4.36	No	No	0	9	5
13	L:L:I136	R:R:R381	3.76	No	No	0	9	7
14	L:L:F137	R:R:Y150	4.13	Yes	Yes	0	9	4
15	L:L:F137	R:R:V153	6.55	Yes	No	0	9	6
16	L:L:F137	R:R:Y157	8.25	Yes	Yes	0	9	8
17	L:L:F137	R:R:L382	3.65	Yes	No	0	9	5
18	L:L:F137	R:R:L386	3.65	Yes	No	0	9	8
19	L:L:T138	R:R:K206	12.01	No	Yes	0	9	6
20	L:L:D139	L:L:R143	11.91	No	No	0	9	9
21	L:L:D139	R:R:N300	5.39	No	No	0	9	6
22	L:L:S140	R:R:Y150	5.09	No	Yes	0	9	4
23	L:L:S140	R:R:K378	7.65	No	No	0	9	5
24	L:L:R145	L:L:Y141	13.38	No	No	1	9	9
25	L:L:Y141	R:R:Y150	7.94	No	Yes	0	9	4
26	L:L:Y141	R:R:Y211	16.88	No	Yes	1	9	4
27	L:L:S142	R:R:Y211	5.09	No	Yes	0	9	4
28	L:L:S142	R:R:D298	8.83	No	No	0	9	6
29	L:L:Q147	L:L:R143	4.67	No	No	0	9	9
30	L:L:R143	R:R:D301	4.76	No	No	0	9	4
31	L:L:M148	L:L:Y144	13.17	No	Yes	0	9	9
32	L:L:Y144	R:R:Q146	4.51	Yes	No	0	9	1
33	L:L:Y144	R:R:D147	5.75	Yes	No	0	9	1
34	L:L:Y144	R:R:Y150	7.94	Yes	Yes	0	9	4
35	L:L:R145	R:R:Y211	11.32	No	Yes	1	9	4
36	L:L:K146	R:R:I83	10.18	No	No	0	9	4
37	L:L:K146	R:R:M299	4.32	No	No	0	9	5
38	L:L:Q147	R:R:F84	4.68	No	Yes	0	9	5
39	L:L:K151	L:L:M148	5.76	No	No	0	9	9
40	L:L:V150	R:R:F84	5.24	No	Yes	0	9	5
41	L:L:K151	R:R:F136	6.2	No	No	0	9	3
42	L:L:V157	L:L:Y153	10.09	No	No	0	9	9
43	L:L:Y153	R:R:K28	7.17	No	No	4	9	3
44	L:L:Y153	R:R:Q31	4.51	No	Yes	4	9	4
45	L:L:L154	R:R:F81	8.53	No	Yes	0	9	6
46	L:L:V157	R:R:N60	10.35	No	No	0	9	6
47	R:R:F27	R:R:I26	7.54	No	No	0	6	5
48	R:R:K28	R:R:Q31	10.85	No	Yes	4	3	4
49	R:R:E30	R:R:L80	6.63	No	No	0	7	5
50	R:R:Q31	R:R:W58	18.62	Yes	No	0	4	7
51	R:R:N60	R:R:Q31	11.88	No	Yes	0	6	4
52	R:R:C34	R:R:C63	7.28	No	No	0	9	9
53	R:R:E36	R:R:L35	7.95	No	No	5	4	2
54	R:R:L35	R:R:Q39	7.99	No	No	5	2	4
55	R:R:L35	R:R:W58	18.22	No	No	0	2	7
56	R:R:E36	R:R:Q39	3.82	No	No	5	4	4
57	R:R:E36	R:R:R40	5.82	No	No	0	4	5
58	R:R:G56	R:R:I38	3.53	No	No	0	5	6
59	R:R:C63	R:R:I38	3.27	No	No	0	9	6
60	R:R:P52	R:R:P55	3.9	No	Yes	0	1	4
61	R:R:C118	R:R:C54	7.28	No	Yes	2	9	9
62	R:R:C54	R:R:W123	10.45	Yes	Yes	2	9	9
63	R:R:G122	R:R:P55	4.06	No	Yes	0	9	4
64	R:R:D59	R:R:M57	8.32	No	No	0	9	6
65	R:R:C63	R:R:W58	9.14	No	No	0	9	7
66	R:R:D59	R:R:R116	4.76	No	Yes	0	9	9
67	R:R:F81	R:R:I61	5.02	Yes	No	0	6	4
68	R:R:F131	R:R:I61	21.35	No	No	0	4	4
69	R:R:T62	R:R:W64	8.49	No	Yes	0	5	9
70	R:R:P78	R:R:T62	3.5	No	No	0	9	5
71	R:R:V73	R:R:W64	4.9	No	Yes	2	8	9
72	R:R:V75	R:R:W64	7.36	No	Yes	0	6	9
73	R:R:R116	R:R:W64	32.99	Yes	Yes	2	9	9
74	R:R:W123	R:R:W64	5.62	Yes	Yes	2	9	9
75	R:R:E71	R:R:H68	9.85	No	No	0	3	2
76	R:R:V73	R:R:W123	7.36	No	Yes	2	8	9
77	R:R:L74	R:R:S115	4.5	No	No	0	4	5
78	R:R:G112	R:R:S76	3.71	No	No	0	6	4
79	R:R:C77	R:R:F81	8.38	No	Yes	0	9	6
80	R:R:C134	R:R:C77	7.28	No	No	0	9	9
81	R:R:F81	R:R:G135	4.52	Yes	No	0	6	3
82	R:R:F84	R:R:I83	3.77	Yes	No	0	5	4
83	R:R:F136	R:R:F84	7.5	No	Yes	0	3	5
84	R:R:D137	R:R:F84	10.75	No	Yes	0	1	5
85	R:R:D137	R:R:N85	10.77	No	No	0	1	3
86	R:R:D87	R:R:P86	4.83	No	No	0	2	2
87	R:R:G112	R:R:M111	3.49	No	No	0	6	3
88	R:R:M111	R:R:V113	4.56	No	No	0	3	1
89	R:R:C134	R:R:V114	3.42	No	No	0	9	6
90	R:R:R116	R:R:W123	4	Yes	Yes	2	9	9
91	R:R:F131	R:R:R116	6.41	No	Yes	0	4	9
92	R:R:N117	R:R:S124	5.96	No	No	6	4	6
93	R:R:N117	R:R:P126	4.89	No	No	6	4	5
94	R:R:C118	R:R:W123	9.14	No	Yes	2	9	9
95	R:R:E120	R:R:T119	4.23	No	No	0	1	6
96	R:R:P126	R:R:S124	7.13	No	No	6	5	6
97	R:R:E125	R:R:P128	7.86	No	No	0	4	4
98	R:R:F127	R:R:Y130	35.07	No	No	0	3	8
99	R:R:D132	R:R:H129	17.65	No	No	0	6	2
100	R:R:A133	R:R:Y130	4	No	No	0	6	8
101	R:R:D132	R:R:F136	3.58	No	No	0	6	3
102	R:R:D147	R:R:L151	8.14	No	No	0	1	2
103	R:R:S152	R:R:Y148	8.9	No	No	0	4	1
104	R:R:Y149	R:R:Y150	8.94	Yes	Yes	0	4	4
105	R:R:V153	R:R:Y149	3.79	No	Yes	0	6	4
106	R:R:R379	R:R:Y149	9.26	No	Yes	0	4	4
107	R:R:L382	R:R:Y149	3.52	No	Yes	0	5	4
108	R:R:V383	R:R:Y149	5.05	No	Yes	0	5	4
109	R:R:K154	R:R:Y157	4.78	No	Yes	0	5	8
110	R:R:K154	R:R:Y211	4.78	No	Yes	0	5	4
111	R:R:G387	R:R:L156	3.42	No	No	0	5	6
112	R:R:Y157	R:R:Y161	7.94	Yes	Yes	1	8	7
113	R:R:V203	R:R:Y157	3.79	No	Yes	1	7	8
114	R:R:D207	R:R:Y157	9.2	Yes	Yes	1	7	8
115	R:R:S390	R:R:Y157	3.82	No	Yes	1	9	8
116	R:R:G160	R:R:V159	3.68	No	No	0	9	6
117	R:R:F391	R:R:G160	9.03	No	No	0	7	9
118	R:R:R199	R:R:Y161	9.26	Yes	Yes	1	8	7
119	R:R:A200	R:R:Y161	4	No	Yes	0	8	7
120	R:R:V203	R:R:Y161	8.83	No	Yes	1	7	7
121	R:R:S390	R:R:Y161	16.53	No	Yes	1	9	7
122	R:R:F204	R:R:S162	5.28	No	No	0	7	7
123	R:R:F394	R:R:T163	3.89	No	No	0	5	5
124	R:R:F394	R:R:T167	10.38	No	No	0	5	7
125	R:R:A397	R:R:T167	3.36	No	No	0	9	7
126	R:R:F402	R:R:T167	3.89	Yes	No	0	8	7
127	R:R:F193	R:R:L168	6.09	No	No	0	8	9
128	R:R:G393	R:R:L168	3.42	No	No	0	9	9
129	R:R:A397	R:R:L168	3.15	No	No	0	9	9
130	R:R:F402	R:R:T170	3.89	Yes	No	0	8	5
131	R:R:A171	R:R:C401	3.61	No	Yes	0	9	9
132	R:R:C176	R:R:M172	3.24	No	Yes	7	4	6
133	R:R:M172	R:R:M190	7.22	Yes	No	7	6	6
134	R:R:C401	R:R:I174	3.27	Yes	No	0	9	8
135	R:R:C401	R:R:L175	3.17	Yes	No	0	9	8
136	R:R:C176	R:R:M190	3.24	No	No	7	4	6
137	R:R:F178	R:R:L181	6.09	Yes	Yes	0	6	9
138	R:R:E410	R:R:F178	17.49	Yes	Yes	3	8	6
139	R:R:F178	R:R:I411	5.02	Yes	No	0	6	5
140	R:R:F178	R:R:K414	6.2	Yes	No	3	6	5
141	R:R:H182	R:R:R179	7.9	No	No	0	8	8
142	R:R:K180	R:R:L181	4.23	No	Yes	0	7	9
143	R:R:E410	R:R:K180	13.5	Yes	No	0	8	7
144	R:R:L181	R:R:V407	4.47	Yes	No	0	9	9
145	R:R:F187	R:R:H182	6.79	No	No	0	6	8
146	R:R:C183	R:R:R185	5.57	No	No	8	8	9
147	R:R:C183	R:R:N186	6.3	No	No	8	8	9
148	R:R:T184	R:R:Y250	6.24	No	No	0	7	8
149	R:R:N186	R:R:R185	4.82	No	No	8	9	9
150	R:R:H189	R:R:R185	4.51	No	No	0	9	9
151	R:R:F187	R:R:F266	8.57	No	No	0	6	6
152	R:R:I188	R:R:W243	3.52	No	Yes	0	9	9
153	R:R:E247	R:R:I188	6.83	Yes	No	0	9	9
154	R:R:F266	R:R:I188	3.77	No	No	0	6	9
155	R:R:E247	R:R:H189	4.92	Yes	No	0	9	9
156	R:R:H189	R:R:Y400	7.62	No	No	0	9	9
157	R:R:N191	R:R:W243	14.69	No	Yes	9	8	9
158	R:R:N191	R:R:W274	5.65	No	Yes	9	8	8
159	R:R:L192	R:R:S195	4.5	Yes	No	0	9	9
160	R:R:F196	R:R:L192	8.53	Yes	Yes	1	8	9
161	R:R:L192	R:R:L244	4.15	Yes	Yes	1	9	9
162	R:R:E247	R:R:L192	13.25	Yes	Yes	0	9	9
163	R:R:V194	R:R:W274	3.68	No	Yes	0	4	8
164	R:R:N240	R:R:S195	7.45	Yes	No	0	9	9
165	R:R:S195	R:R:W243	6.18	No	Yes	0	9	9
166	R:R:F196	R:R:N240	15.71	Yes	Yes	1	8	9
167	R:R:F196	R:R:L244	4.87	Yes	Yes	1	8	9
168	R:R:F196	R:R:Q392	7.03	Yes	Yes	1	8	9
169	R:R:F196	R:R:G393	4.52	Yes	No	0	8	9
170	R:R:C236	R:R:L198	6.35	No	No	0	5	7
171	R:R:R199	R:R:V237	7.85	Yes	Yes	1	8	6
172	R:R:N240	R:R:R199	9.64	Yes	Yes	1	9	8
173	R:R:R199	R:R:Y241	4.12	Yes	Yes	1	8	7
174	R:R:R199	R:R:Y366	4.12	Yes	Yes	1	8	8
175	R:R:F233	R:R:S202	5.28	Yes	No	0	6	6
176	R:R:C236	R:R:S202	6.89	No	No	0	5	6
177	R:R:D207	R:R:V203	4.38	Yes	No	1	7	7
178	R:R:I205	R:R:V229	4.61	No	No	0	6	6
179	R:R:D207	R:R:K206	4.15	Yes	Yes	1	7	6
180	R:R:K206	R:R:L210	5.64	Yes	Yes	1	6	7
181	R:R:K206	R:R:Y211	3.58	Yes	Yes	1	6	4
182	R:R:K206	R:R:M230	5.76	Yes	No	1	6	6
183	R:R:F233	R:R:K206	17.37	Yes	Yes	1	6	6
184	R:R:I209	R:R:W208	3.52	Yes	No	10	5	4
185	R:R:A212	R:R:W208	3.89	No	No	0	4	4
186	R:R:E213	R:R:W208	16.36	No	No	10	3	4
187	R:R:E213	R:R:I209	4.1	No	Yes	10	3	5
188	R:R:L210	R:R:Y211	10.55	Yes	Yes	1	7	4
189	R:R:L210	R:R:M230	4.24	Yes	No	1	7	6
190	R:R:C296	R:R:L210	3.17	Yes	Yes	1	9	7
191	R:R:D298	R:R:L210	4.07	No	Yes	1	6	7
192	R:R:G295	R:R:S222	3.71	No	No	0	4	6
193	R:R:C226	R:R:T223	3.38	No	No	0	9	3
194	R:R:C226	R:R:C296	7.28	No	Yes	0	9	9
195	R:R:D293	R:R:K227	6.91	No	No	1	6	7
196	R:R:K227	R:R:W297	8.12	No	Yes	1	7	8
197	R:R:H234	R:R:M230	3.94	Yes	No	1	7	6
198	R:R:C236	R:R:F232	8.38	No	No	0	5	4
199	R:R:F233	R:R:H234	6.79	Yes	Yes	1	6	7
200	R:R:F233	R:R:V237	3.93	Yes	Yes	1	6	6
201	R:R:H234	R:R:W284	4.23	Yes	Yes	1	7	8
202	R:R:H234	R:R:W306	3.17	Yes	Yes	1	7	5
203	R:R:H234	R:R:I309	5.3	Yes	No	1	7	7
204	R:R:P277	R:R:Y235	4.17	Yes	No	0	9	9
205	R:R:T278	R:R:Y235	6.24	No	No	0	4	9
206	R:R:V281	R:R:Y235	5.05	No	No	0	7	9
207	R:R:P277	R:R:V238	7.07	Yes	No	0	9	6
208	R:R:C280	R:R:V238	5.12	No	No	0	5	6
209	R:R:S239	R:R:W274	7.41	No	Yes	0	8	8
210	R:R:P277	R:R:S239	3.56	Yes	No	0	9	8
211	R:R:L244	R:R:N240	4.12	Yes	Yes	1	9	9
212	R:R:V313	R:R:Y241	11.36	No	Yes	0	7	7
213	R:R:I317	R:R:Y241	4.84	No	Yes	1	7	7
214	R:R:Y241	R:R:Y366	21.84	Yes	Yes	1	7	8
215	R:R:F242	R:R:T276	9.08	No	No	0	5	4
216	R:R:I246	R:R:W243	5.87	No	Yes	0	8	9
217	R:R:W243	R:R:W274	23.43	Yes	Yes	9	9	8
218	R:R:L244	R:R:Q392	6.65	Yes	Yes	1	9	9
219	R:R:F245	R:R:I246	3.77	Yes	No	0	8	8
220	R:R:F245	R:R:L249	6.09	Yes	No	0	8	6
221	R:R:F245	R:R:V319	6.55	Yes	No	0	8	6
222	R:R:E247	R:R:L361	6.63	Yes	No	0	9	9
223	R:R:F362	R:R:G248	7.53	Yes	No	0	9	9
224	R:R:L249	R:R:Y269	8.21	No	Yes	0	6	7
225	R:R:L254	R:R:Y250	14.07	No	No	0	7	8
226	R:R:Y250	R:R:Y269	4.96	No	Yes	0	8	7
227	R:R:I327	R:R:L251	5.71	No	No	0	9	9
228	R:R:F252	R:R:V256	9.18	No	No	0	7	6
229	R:R:F252	R:R:L323	7.31	No	No	0	7	8
230	R:R:F252	R:R:I327	3.77	No	No	0	7	9
231	R:R:T253	R:R:Y269	4.99	No	Yes	0	7	7
232	R:R:I330	R:R:L255	4.28	No	No	0	8	8
233	R:R:E257	R:R:Y265	3.37	No	No	0	5	4
234	R:R:F259	R:R:T258	9.08	No	No	0	7	7
235	R:R:F260	R:R:R263	4.28	No	No	0	6	4
236	R:R:R263	R:R:Y265	14.4	No	No	0	4	4
237	R:R:R264	R:R:Y267	4.12	No	No	0	5	3
238	R:R:Y265	R:R:Y269	5.96	No	Yes	0	4	7
239	R:R:F266	R:R:T270	5.19	No	No	0	6	5
240	R:R:W268	R:R:Y267	11.58	No	No	0	3	3
241	R:R:I271	R:R:Y267	9.67	No	No	0	4	3
242	R:R:I272	R:R:T276	6.08	No	No	0	6	4
243	R:R:G275	R:R:T278	3.64	No	No	0	7	4
244	R:R:P277	R:R:T276	3.5	Yes	No	0	9	4
245	R:R:C280	R:R:V281	3.42	No	No	0	5	7
246	R:R:R288	R:R:W284	10	Yes	Yes	1	8	8
247	R:R:W284	R:R:W297	3.75	Yes	Yes	1	8	8
248	R:R:I309	R:R:W284	8.22	No	Yes	1	7	8
249	R:R:T286	R:R:Y290	6.24	No	No	0	4	3
250	R:R:F291	R:R:L287	3.65	No	No	0	3	4
251	R:R:D292	R:R:R288	9.53	No	Yes	1	5	8
252	R:R:R288	R:R:T294	3.88	Yes	No	1	8	3
253	R:R:R288	R:R:W297	23.99	Yes	Yes	1	8	8
254	R:R:L289	R:R:W297	6.83	No	Yes	0	3	8
255	R:R:F291	R:R:Y290	4.13	No	No	0	3	3
256	R:R:D292	R:R:T294	8.67	No	No	1	5	3
257	R:R:D293	R:R:W297	8.93	No	Yes	1	6	8
258	R:R:C296	R:R:D298	4.67	Yes	No	1	9	6
259	R:R:N300	R:R:W306	24.86	No	Yes	0	6	5
260	R:R:L305	R:R:S302	7.51	Yes	No	0	2	5
261	R:R:I309	R:R:W306	5.87	No	Yes	1	7	5
262	R:R:K310	R:R:W306	5.8	Yes	Yes	1	6	5
263	R:R:E374	R:R:W306	8.72	Yes	Yes	1	4	5
264	R:R:K310	R:R:W307	4.64	Yes	No	0	6	6
265	R:R:E374	R:R:K310	4.05	Yes	Yes	1	4	6
266	R:R:G311	R:R:P312	4.06	No	No	0	4	9
267	R:R:G315	R:R:M318	5.24	No	No	0	4	4
268	R:R:I317	R:R:Y366	4.84	No	Yes	1	7	8
269	R:R:A370	R:R:I317	3.25	No	No	0	6	7
270	R:R:F371	R:R:M318	3.73	No	No	0	4	4
271	R:R:F362	R:R:N320	10.87	Yes	No	0	9	9
272	R:R:F321	R:R:I325	5.02	No	No	0	6	5
273	R:R:F321	R:R:I364	3.77	No	No	0	6	6
274	R:R:F321	R:R:T367	5.19	No	No	0	6	6
275	R:R:F324	R:R:I328	10.05	Yes	No	0	9	7
276	R:R:F324	R:R:L358	4.87	Yes	No	11	9	9
277	R:R:F324	R:R:F362	5.36	Yes	Yes	11	9	9
278	R:R:F324	R:R:I364	8.79	Yes	No	0	9	6
279	R:R:G326	R:R:I325	3.53	No	No	0	8	5
280	R:R:I328	R:R:T355	4.56	No	No	0	7	9
281	R:R:L331	R:R:S354	4.5	No	No	0	9	9
282	R:R:I347	R:R:Y348	6.04	No	No	0	7	7
283	R:R:R350	R:R:R353	7.46	No	No	0	8	8
284	R:R:L357	R:R:R353	6.07	No	No	0	8	8
285	R:R:F362	R:R:L358	3.65	Yes	No	11	9	9
286	R:R:I359	R:R:P360	3.39	No	No	0	8	9
287	R:R:I359	R:R:I364	7.36	No	No	0	8	6
288	R:R:P360	R:R:V395	3.53	No	No	0	9	6
289	R:R:F362	R:R:L361	8.53	Yes	No	0	9	9
290	R:R:L361	R:R:Y400	15.24	No	No	0	9	9
291	R:R:G363	R:R:H365	3.18	No	Yes	1	9	9
292	R:R:G363	R:R:Q392	3.29	No	Yes	1	9	9
293	R:R:H365	R:R:Y366	16.33	Yes	Yes	1	9	8
294	R:R:F384	R:R:H365	3.39	No	Yes	0	3	9
295	R:R:H365	R:R:Q392	12.36	Yes	Yes	1	9	9
296	R:R:E385	R:R:Y366	6.73	No	Yes	0	8	8
297	R:R:Q392	R:R:Y366	3.38	Yes	Yes	1	9	8
298	R:R:F369	R:R:V368	5.24	Yes	No	0	6	6
299	R:R:F369	R:R:S372	3.96	Yes	No	0	6	5
300	R:R:F369	R:R:R381	11.76	Yes	No	0	6	7
301	R:R:E385	R:R:F369	4.66	No	Yes	0	8	6
302	R:R:P373	R:R:S372	3.56	No	No	0	8	5
303	R:R:P373	R:R:V376	7.07	No	No	0	8	4
304	R:R:K378	R:R:L382	5.64	No	No	0	5	5
305	R:R:E380	R:R:R379	4.65	No	No	0	5	4
306	R:R:F384	R:R:L388	4.87	No	No	0	3	7
307	R:R:F402	R:R:V398	3.93	Yes	No	0	8	5
308	R:R:C401	R:R:F402	5.59	Yes	Yes	0	9	8
309	R:R:E406	R:R:N404	13.15	No	No	0	9	9
310	R:R:N404	R:R:V407	5.91	No	No	0	9	9
311	R:R:E410	R:R:R413	9.3	Yes	No	3	8	7
312	R:R:E410	R:R:K414	10.8	Yes	No	3	8	5
313	R:R:K414	R:R:R413	4.95	No	No	3	5	7
314	R:R:E30	R:R:P78	3.14	No	No	0	7	9
315	R:R:F204	R:R:Y161	3.09	No	Yes	0	7	7
316	R:R:I209	R:R:V229	3.07	Yes	No	0	5	6
317	R:R:M172	R:R:V194	3.04	Yes	No	0	6	4
318	R:R:K310	R:R:V314	3.04	Yes	No	0	6	4
319	R:R:M197	R:R:T169	3.01	No	No	0	7	4
320	R:R:L351	R:R:S354	3	Yes	No	0	9	9
321	L:L:L154	L:L:V150	2.98	No	No	0	9	9
322	L:L:L158	L:L:V157	2.98	No	No	0	9	9
323	R:R:L287	R:R:V283	2.98	No	Yes	0	4	4
324	R:R:L323	R:R:V319	2.98	No	No	0	8	6
325	R:R:L351	R:R:V332	2.98	Yes	No	0	9	6
326	R:R:L399	R:R:V395	2.98	No	No	0	8	6
327	R:R:L165	R:R:T169	2.95	No	No	0	7	4
328	R:R:L351	R:R:T355	2.95	Yes	No	0	9	9
329	R:R:I330	R:R:K334	2.91	No	No	0	8	9
330	R:R:M172	R:R:M197	2.89	Yes	No	0	6	7
331	R:R:F242	R:R:P312	2.89	No	No	0	5	9
332	R:R:Q333	R:R:V329	2.87	No	No	0	7	8
333	R:R:I201	R:R:L165	2.85	No	No	0	4	7
334	R:R:I327	R:R:L255	2.85	No	No	0	9	8
335	R:R:E262	R:R:T184	2.82	No	No	0	6	7
336	R:R:G273	R:R:W243	2.81	No	Yes	0	9	9
337	R:R:L287	R:R:L305	2.77	No	Yes	0	4	2
338	R:R:L335	R:R:L351	2.77	No	Yes	0	8	9
339	R:R:A370	R:R:F371	2.77	No	No	0	6	4
340	R:R:L181	R:R:N186	2.75	Yes	No	0	9	9
341	R:R:F127	R:R:S115	2.64	No	No	0	3	5
342	R:R:F245	R:R:S316	2.64	Yes	No	0	8	7
343	R:R:F369	R:R:S377	2.64	Yes	No	0	6	5
344	R:R:F391	R:R:T163	2.59	No	No	0	7	5
345	R:R:E30	R:R:Q31	2.55	No	Yes	0	7	4
346	R:R:S164	R:R:Y161	2.54	No	Yes	0	9	7
347	R:R:V231	R:R:W284	2.45	No	Yes	1	6	8
348	R:R:V231	R:R:W297	2.45	No	Yes	1	6	8
349	R:R:L305	R:R:R288	2.43	Yes	Yes	0	2	8
350	R:R:L335	R:R:R350	2.43	No	No	0	8	8
351	R:R:E79	R:R:R82	2.33	No	No	0	2	4
352	R:R:F259	R:R:F260	2.14	No	No	0	7	6
353	R:R:C134	R:R:G112	1.96	No	No	0	9	6
354	R:R:C54	R:R:P55	1.88	Yes	Yes	0	9	4
355	R:R:G53	R:R:V69	1.84	No	No	0	1	6
356	R:R:G70	R:R:V69	1.84	No	No	0	7	6
357	R:R:G326	R:R:V329	1.84	No	No	0	8	8
358	R:R:G393	R:R:V396	1.84	No	No	0	9	9
359	R:R:G122	R:R:T119	1.82	No	No	0	9	6
360	R:R:A67	R:R:C54	1.81	No	Yes	2	8	9
361	R:R:A67	R:R:C118	1.81	No	No	2	8	9
362	R:R:P338	R:R:S337	1.78	No	No	0	6	7
363	R:R:C296	R:R:S222	1.72	Yes	No	0	9	6
364	R:R:G387	R:R:L386	1.71	No	No	0	5	8
365	R:R:A285	R:R:V231	1.7	No	No	0	5	6
366	R:R:G405	R:R:N404	1.7	No	No	0	5	9
367	R:R:A155	R:R:T158	1.68	No	No	0	4	7
368	R:R:K65	R:R:P66	1.67	No	No	0	7	4
369	R:R:C226	R:R:I209	1.64	No	Yes	0	9	5
370	R:R:L254	R:R:P261	1.64	No	No	0	7	7
371	R:R:N42	R:R:P66	1.63	No	No	0	2	4
372	R:R:N85	R:R:P86	1.63	No	No	0	3	2
373	R:R:A32	R:R:K28	1.61	No	No	0	2	3
374	R:R:A32	R:R:K29	1.61	No	No	0	2	5
375	R:R:D121	R:R:P55	1.61	No	Yes	0	4	4
376	R:R:V279	R:R:V283	1.6	No	Yes	0	4	4
377	R:R:V283	R:R:V308	1.6	Yes	No	0	4	8
378	R:R:T282	R:R:V281	1.59	No	No	0	3	7
379	R:R:T282	R:R:V283	1.59	No	Yes	0	3	4
380	R:R:G389	R:R:H365	1.59	No	Yes	0	7	9
381	R:R:A304	R:R:L305	1.58	No	Yes	0	1	2
382	R:R:E125	R:R:P126	1.57	No	No	0	4	5
383	R:R:A67	R:R:E71	1.51	No	No	0	8	3
384	R:R:L403	R:R:V398	1.49	No	No	0	7	5
385	R:R:D207	R:R:T158	1.45	Yes	No	0	7	7
386	R:R:F127	R:R:P128	1.44	No	No	0	3	4
387	R:R:E120	R:R:V69	1.43	No	No	0	1	6
388	R:R:E225	R:R:T223	1.41	No	No	0	5	3
389	R:R:K412	R:R:Q408	1.36	No	No	0	6	7
390	R:R:L403	R:R:Q408	1.33	No	No	0	7	7
391	R:R:E43	R:R:N42	1.31	No	No	0	2	2
392	R:R:R177	R:R:V173	1.31	No	No	0	3	1
393	R:R:E374	R:R:N375	1.31	Yes	No	0	4	5
394	R:R:V113	R:R:Y130	1.26	No	No	0	1	8
395	L:L:K146	R:R:F27	1.24	No	No	0	9	6
396	R:R:K37	R:R:R40	1.24	No	No	0	4	5
397	L:L:K151	R:R:Y139	1.19	No	No	0	9	4
398	R:R:D110	R:R:R82	1.19	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:H132	7.945	4	0	9
2	L:L:D134	6.9925	4	1	9
3	L:L:F137	5.246	5	0	9
4	L:L:Y144	7.8425	4	0	9
5	R:R:Q31	9.682	5	4	4
6	R:R:C54	5.355	4	2	9
7	R:R:P55	2.8625	4	0	4
8	R:R:W64	11.872	5	2	9
9	R:R:F81	6.6125	4	0	6
10	R:R:F84	6.388	5	0	5
11	R:R:R116	12.04	4	2	9
12	R:R:W123	7.314	5	2	9
13	R:R:Y149	6.112	5	0	4
14	R:R:Y150	6.808	5	0	4
15	R:R:Y157	6.29667	6	1	8
16	R:R:Y161	7.38625	8	1	7
17	R:R:M172	4.0975	4	7	6
18	R:R:F178	8.7	4	3	6
19	R:R:L181	4.385	4	0	9
20	R:R:L192	7.6075	4	1	9
21	R:R:F196	8.132	5	1	8
22	R:R:R199	7.61833	6	1	8
23	R:R:K206	8.085	6	1	6
24	R:R:D207	4.795	4	1	7
25	R:R:I209	3.0825	4	10	5
26	R:R:L210	5.534	5	1	7
27	R:R:Y211	8.7	6	1	4
28	R:R:F233	7.868	5	1	6
29	R:R:H234	4.686	5	1	7
30	R:R:V237	7.845	4	1	6
31	R:R:N240	9.23	4	1	9
32	R:R:Y241	9.52	5	1	7
33	R:R:W243	9.41667	6	9	9
34	R:R:L244	4.9475	4	1	9
35	R:R:F245	4.7625	4	0	8
36	R:R:E247	7.9075	4	0	9
37	R:R:Y269	6.03	4	0	7
38	R:R:W274	10.0425	4	9	8
39	R:R:P277	4.575	4	0	9
40	R:R:V283	1.9425	4	0	4
41	R:R:W284	5.73	5	1	8
42	R:R:R288	9.966	5	1	8
43	R:R:C296	4.21	4	1	9
44	R:R:W297	9.01167	6	1	8
45	R:R:L305	3.5725	4	0	2
46	R:R:W306	9.12833	6	1	5
47	R:R:K310	4.3825	4	1	6
48	R:R:F324	7.2675	4	11	9
49	R:R:L351	2.925	4	0	9
50	R:R:F362	7.188	5	11	9
51	R:R:H365	7.37	5	1	9
52	R:R:Y366	9.54	6	1	8
53	R:R:F369	5.652	5	0	6
54	R:R:E374	6.595	4	1	4
55	R:R:Q392	6.542	5	1	9
56	R:R:C401	3.91	4	0	9
57	R:R:F402	4.325	4	0	8
58	R:R:E410	12.7725	4	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:H132	R:R:V237	29.3858	15.22	Yes	Yes	0	9	6
2	L:L:H132	R:R:Y241	47.4202	5.44	Yes	Yes	0	9	7
3	L:L:H132	R:R:W306	74.9668	6.35	Yes	Yes	0	9	5
4	R:R:Y241	R:R:Y366	17.4406	21.84	Yes	Yes	1	7	8
5	R:R:R199	R:R:V237	42.7661	7.85	Yes	Yes	1	8	6
6	R:R:R199	R:R:Y161	16.4611	9.26	Yes	Yes	1	8	7
7	R:R:R199	R:R:Y241	30.5207	4.12	Yes	Yes	1	8	7
8	R:R:F233	R:R:V237	14.1492	3.93	Yes	Yes	1	6	6
9	L:L:F137	R:R:Y157	12.6377	8.25	Yes	Yes	0	9	8
10	R:R:Y157	R:R:Y161	14.211	7.94	Yes	Yes	1	8	7
11	R:R:F233	R:R:K206	15.9937	17.37	Yes	Yes	1	6	6
12	L:L:D139	R:R:N300	78.5373	5.39	No	No	0	9	6
13	R:R:N300	R:R:W306	79.4247	24.86	No	Yes	0	6	5
14	L:L:D139	L:L:R143	77.6578	11.91	No	No	0	9	9
15	R:R:K206	R:R:L210	10.1363	5.64	Yes	Yes	1	6	7
16	L:L:Q147	L:L:R143	75.9252	4.67	No	No	0	9	9
17	L:L:Y144	R:R:Y150	10.73	7.94	Yes	Yes	0	9	4
18	L:L:Q147	R:R:F84	75.105	4.68	No	Yes	0	9	5
19	L:L:V150	R:R:F84	72.1638	5.24	No	Yes	0	9	5
20	L:L:L154	L:L:V150	71.254	2.98	No	No	0	9	9
21	L:L:L154	R:R:F81	70.3324	8.53	No	Yes	0	9	6
22	R:R:F81	R:R:I61	52.5035	5.02	Yes	No	0	6	4
23	R:R:F131	R:R:I61	51.541	21.35	No	No	0	4	4
24	R:R:F131	R:R:R116	50.5971	6.41	No	Yes	0	4	9
25	R:R:R116	R:R:W64	27.9705	32.99	Yes	Yes	2	9	9
26	R:R:T62	R:R:W64	25.527	8.49	No	Yes	0	5	9
27	R:R:P78	R:R:T62	24.4908	3.5	No	No	0	9	5
28	R:R:E30	R:R:P78	23.4784	3.14	No	No	0	7	9
29	R:R:E30	R:R:Q31	21.3969	2.55	No	Yes	0	7	4
30	R:R:Q31	R:R:W58	10.834	18.62	Yes	No	0	4	7
31	R:R:R116	R:R:W123	19.7104	4	Yes	Yes	2	9	9
32	R:R:C54	R:R:W123	13.9648	10.45	Yes	Yes	2	9	9
33	R:R:C77	R:R:F81	18.2582	8.38	No	Yes	0	9	6
34	R:R:C134	R:R:C77	17.2299	7.28	No	No	0	9	9
35	R:R:C134	R:R:G112	15.1129	1.96	No	No	0	9	6
36	R:R:G112	R:R:M111	12.9853	3.49	No	No	0	6	3
37	R:R:M111	R:R:V113	11.9176	4.56	No	No	0	3	1
38	R:R:V113	R:R:Y130	10.8472	1.26	No	No	0	1	8
39	R:R:N240	R:R:R199	100	9.64	Yes	Yes	1	9	8
40	R:R:F196	R:R:N240	33.2894	15.71	Yes	Yes	1	8	9
41	R:R:F196	R:R:G393	17.6104	4.52	Yes	No	0	8	9
42	R:R:G393	R:R:L168	15.9831	3.42	No	No	0	9	9
43	R:R:A397	R:R:L168	14.3453	3.15	No	No	0	9	9
44	R:R:A397	R:R:T167	13.5225	3.36	No	No	0	9	7
45	R:R:Q392	R:R:Y366	19.9579	3.38	Yes	Yes	1	9	8
46	R:R:F196	R:R:Q392	12.618	7.03	Yes	Yes	1	8	9
47	R:R:N240	R:R:S195	49.3555	7.45	Yes	No	0	9	9
48	R:R:S195	R:R:W243	30.1916	6.18	No	Yes	0	9	9
49	R:R:W243	R:R:W274	14.1373	23.43	Yes	Yes	9	9	8
50	R:R:L192	R:R:S195	23.951	4.5	Yes	No	0	9	9
51	R:R:E247	R:R:L192	80.3252	13.25	Yes	Yes	0	9	9
52	R:R:E247	R:R:H189	33.8411	4.92	Yes	No	0	9	9
53	R:R:H189	R:R:R185	30.9539	4.51	No	No	0	9	9
54	R:R:N186	R:R:R185	27.3267	4.82	No	No	8	9	9
55	R:R:L181	R:R:N186	25.5388	2.75	Yes	No	0	9	9
56	R:R:F178	R:R:L181	10.9618	6.09	Yes	Yes	0	6	9
57	R:R:F196	R:R:L192	33.0933	8.53	Yes	Yes	1	8	9
58	R:R:L244	R:R:N240	22.2421	4.12	Yes	Yes	1	9	9
59	R:R:L192	R:R:L244	30.0428	4.15	Yes	Yes	1	9	9
60	R:R:I246	R:R:W243	17.962	5.87	No	Yes	0	8	9
61	R:R:F245	R:R:I246	17.3037	3.77	Yes	No	0	8	8
62	R:R:E247	R:R:L361	49.6268	6.63	Yes	No	0	9	9
63	R:R:C296	R:R:L210	12.9063	3.17	Yes	Yes	1	9	7
64	R:R:H234	R:R:W284	16.2939	4.23	Yes	Yes	1	7	8
65	R:R:R288	R:R:W284	13.2118	10	Yes	Yes	1	8	8
66	R:R:L305	R:R:R288	10.2376	2.43	Yes	Yes	0	2	8
67	R:R:F362	R:R:L361	46.7922	8.53	Yes	No	0	9	9
68	R:R:F324	R:R:F362	39.6801	5.36	Yes	Yes	11	9	9
69	R:R:F324	R:R:I364	20.0132	8.79	Yes	No	0	9	6
70	R:R:F321	R:R:I364	10.9552	3.77	No	No	0	6	6
71	R:R:F324	R:R:I328	18.2068	10.05	Yes	No	0	9	7
72	R:R:I328	R:R:T355	16.3979	4.56	No	No	0	7	9
73	R:R:L351	R:R:T355	14.5863	2.95	Yes	No	0	9	9
74	R:R:F233	R:R:H234	13.0748	6.79	Yes	Yes	1	6	7
75	L:L:D134	R:R:R199	14.0781	10.72	Yes	Yes	1	9	8
76	L:L:D134	R:R:F233	14.6481	5.97	Yes	Yes	1	9	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:H132	R:R:V237	15.22	0	Yes	Yes	9	6	0	1
L:L:H132	R:R:Y241	5.44	0	Yes	Yes	9	7	0	1
L:L:H132	R:R:W306	6.35	0	Yes	Yes	9	5	0	1
L:L:S133	R:R:E385	7.19	0	No	No	9	8	0	1
L:L:S133	R:R:L386	4.5	0	No	No	9	8	0	1
L:L:D134	R:R:Y161	6.9	1	Yes	Yes	9	7	0	1
L:L:D134	R:R:R199	10.72	1	Yes	Yes	9	8	0	1
L:L:D134	R:R:F233	5.97	1	Yes	Yes	9	6	0	1
L:L:D134	R:R:V237	4.38	1	Yes	Yes	9	6	0	1
L:L:I136	R:R:E374	12.3	0	No	Yes	9	4	0	1
L:L:I136	R:R:K378	4.36	0	No	No	9	5	0	1
L:L:I136	R:R:R381	3.76	0	No	No	9	7	0	1
L:L:F137	R:R:Y150	4.13	0	Yes	Yes	9	4	0	1
L:L:F137	R:R:V153	6.55	0	Yes	No	9	6	0	1
L:L:F137	R:R:Y157	8.25	0	Yes	Yes	9	8	0	1
L:L:F137	R:R:L382	3.65	0	Yes	No	9	5	0	1
L:L:F137	R:R:L386	3.65	0	Yes	No	9	8	0	1
L:L:T138	R:R:K206	12.01	0	No	Yes	9	6	0	1
L:L:D139	R:R:N300	5.39	0	No	No	9	6	0	1
L:L:S140	R:R:Y150	5.09	0	No	Yes	9	4	0	1
L:L:S140	R:R:K378	7.65	0	No	No	9	5	0	1
L:L:Y141	R:R:Y150	7.94	1	No	Yes	9	4	0	1
L:L:Y141	R:R:Y211	16.88	1	No	Yes	9	4	0	1
L:L:S142	R:R:Y211	5.09	0	No	Yes	9	4	0	1
L:L:S142	R:R:D298	8.83	0	No	No	9	6	0	1
L:L:R143	R:R:D301	4.76	0	No	No	9	4	0	1
L:L:Y144	R:R:Q146	4.51	0	Yes	No	9	1	0	1
L:L:Y144	R:R:D147	5.75	0	Yes	No	9	1	0	1
L:L:Y144	R:R:Y150	7.94	0	Yes	Yes	9	4	0	1
L:L:R145	R:R:Y211	11.32	1	No	Yes	9	4	0	1
L:L:K146	R:R:I83	10.18	0	No	No	9	4	0	1
L:L:K146	R:R:M299	4.32	0	No	No	9	5	0	1
L:L:Q147	R:R:F84	4.68	0	No	Yes	9	5	0	1
L:L:V150	R:R:F84	5.24	0	No	Yes	9	5	0	1
L:L:K151	R:R:F136	6.2	0	No	No	9	3	0	1
L:L:Y153	R:R:K28	7.17	4	No	No	9	3	0	1
L:L:Y153	R:R:Q31	4.51	4	No	Yes	9	4	0	1
L:L:L154	R:R:F81	8.53	0	No	Yes	9	6	0	1
L:L:V157	R:R:N60	10.35	0	No	No	9	6	0	1
R:R:F27	R:R:I26	7.54	0	No	No	6	5	1	2
R:R:K28	R:R:Q31	10.85	4	No	Yes	3	4	1	1
R:R:Q31	R:R:W58	18.62	4	Yes	No	4	7	1	2
R:R:N60	R:R:Q31	11.88	0	No	Yes	6	4	1	1
R:R:F81	R:R:I61	5.02	0	Yes	No	6	4	1	2
R:R:C77	R:R:F81	8.38	0	No	Yes	9	6	2	1
R:R:F81	R:R:G135	4.52	0	Yes	No	6	3	1	2
R:R:F84	R:R:I83	3.77	0	Yes	No	5	4	1	1
R:R:F136	R:R:F84	7.5	0	No	Yes	3	5	1	1
R:R:D137	R:R:F84	10.75	0	No	Yes	1	5	2	1
R:R:D132	R:R:F136	3.58	0	No	No	6	3	2	1
R:R:D147	R:R:L151	8.14	0	No	No	1	2	1	2
R:R:Y149	R:R:Y150	8.94	0	Yes	Yes	4	4	2	1
R:R:V153	R:R:Y149	3.79	0	No	Yes	6	4	1	2
R:R:L382	R:R:Y149	3.52	0	No	Yes	5	4	1	2
R:R:K154	R:R:Y157	4.78	0	No	Yes	5	8	2	1
R:R:K154	R:R:Y211	4.78	0	No	Yes	5	4	2	1
R:R:Y157	R:R:Y161	7.94	1	Yes	Yes	8	7	1	1
R:R:V203	R:R:Y157	3.79	1	No	Yes	7	8	2	1
R:R:D207	R:R:Y157	9.2	1	Yes	Yes	7	8	2	1
R:R:S390	R:R:Y157	3.82	1	No	Yes	9	8	2	1
R:R:R199	R:R:Y161	9.26	1	Yes	Yes	8	7	1	1
R:R:A200	R:R:Y161	4	0	No	Yes	8	7	2	1
R:R:V203	R:R:Y161	8.83	1	No	Yes	7	7	2	1
R:R:S390	R:R:Y161	16.53	1	No	Yes	9	7	2	1
R:R:R199	R:R:V237	7.85	1	Yes	Yes	8	6	1	1
R:R:N240	R:R:R199	9.64	1	Yes	Yes	9	8	2	1
R:R:R199	R:R:Y241	4.12	1	Yes	Yes	8	7	1	1
R:R:R199	R:R:Y366	4.12	1	Yes	Yes	8	8	1	2
R:R:F233	R:R:S202	5.28	1	Yes	No	6	6	1	2
R:R:D207	R:R:V203	4.38	1	Yes	No	7	7	2	2
R:R:D207	R:R:K206	4.15	1	Yes	Yes	7	6	2	1
R:R:K206	R:R:L210	5.64	1	Yes	Yes	6	7	1	2
R:R:K206	R:R:Y211	3.58	1	Yes	Yes	6	4	1	1
R:R:K206	R:R:M230	5.76	1	Yes	No	6	6	1	2
R:R:F233	R:R:K206	17.37	1	Yes	Yes	6	6	1	1
R:R:L210	R:R:Y211	10.55	1	Yes	Yes	7	4	2	1
R:R:L210	R:R:M230	4.24	1	Yes	No	7	6	2	2
R:R:C296	R:R:L210	3.17	1	Yes	Yes	9	7	2	2
R:R:D298	R:R:L210	4.07	1	No	Yes	6	7	1	2
R:R:H234	R:R:M230	3.94	1	Yes	No	7	6	2	2
R:R:F233	R:R:H234	6.79	1	Yes	Yes	6	7	1	2
R:R:F233	R:R:V237	3.93	1	Yes	Yes	6	6	1	1
R:R:H234	R:R:W306	3.17	1	Yes	Yes	7	5	2	1
R:R:H234	R:R:I309	5.3	1	Yes	No	7	7	2	2
R:R:V313	R:R:Y241	11.36	0	No	Yes	7	7	2	1
R:R:I317	R:R:Y241	4.84	1	No	Yes	7	7	2	1
R:R:Y241	R:R:Y366	21.84	1	Yes	Yes	7	8	1	2
R:R:C296	R:R:D298	4.67	1	Yes	No	9	6	2	1
R:R:N300	R:R:W306	24.86	0	No	Yes	6	5	1	1
R:R:I309	R:R:W306	5.87	1	No	Yes	7	5	2	1
R:R:K310	R:R:W306	5.8	1	Yes	Yes	6	5	2	1
R:R:E374	R:R:W306	8.72	1	Yes	Yes	4	5	1	1
R:R:E374	R:R:K310	4.05	1	Yes	Yes	4	6	1	2
R:R:I317	R:R:Y366	4.84	1	No	Yes	7	8	2	2
R:R:E385	R:R:Y366	6.73	0	No	Yes	8	8	1	2
R:R:F369	R:R:R381	11.76	0	Yes	No	6	7	2	1
R:R:E385	R:R:F369	4.66	0	No	Yes	8	6	1	2
R:R:K378	R:R:L382	5.64	0	No	No	5	5	1	1
R:R:F204	R:R:Y161	3.09	0	No	Yes	7	7	2	1
R:R:E30	R:R:Q31	2.55	0	No	Yes	7	4	2	1
R:R:S164	R:R:Y161	2.54	0	No	Yes	9	7	2	1
R:R:G387	R:R:L386	1.71	0	No	No	5	8	2	1
R:R:A32	R:R:K28	1.61	0	No	No	2	3	2	1
R:R:E374	R:R:N375	1.31	1	Yes	No	4	5	1	2
L:L:K146	R:R:F27	1.24	0	No	No	9	6	0	1
L:L:K151	R:R:Y139	1.19	0	No	No	9	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9P94_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.15
Number of Linked Nodes	346
Number of Links	398
Number of Hubs	58
Number of Links mediated by Hubs	213
Number of Communities	11
Number of Nodes involved in Communities	75
Number of Links involved in Communities	105

Path Summary
Number Of Nodes in MetaPath	77
Number Of Links MetaPath	76
Number of Shortest Paths	137057
Length Of Smallest Path	3
Average Path Length	18.1192
Length of Longest Path	39
Minimum Path Strength	1.345
Average Path Strength	7.46856
Maximum Path Strength	20.74
Minimum Path Correlation	0.7
Average Path Correlation	0.958647
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	57.7395
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.1711
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • system process • regulation of biological process • nervous system process • neuromuscular process • regulation of system process • biological regulation • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • sensory perception of chemical stimulus • sensory perception • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • serotonin receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • small GTPase binding • protein binding • binding • enzyme binding • GTPase binding • molecular transducer activity • signaling receptor activity • adenylate cyclase binding • vasoactive intestinal polypeptide receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • neuropeptide binding • peptide binding • peptide hormone binding • hormone binding • peptide receptor activity • G protein-coupled peptide receptor activity • pituitary adenylate cyclase-activating polypeptide receptor activity • response to stimulus • response to chemical • response to xenobiotic stimulus • developmental process • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • cellular developmental process • cell differentiation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • multicellular organismal process • response to stress • multicellular organismal response to stress • response to alcohol • response to oxygen-containing compound • response to ethanol • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell surface receptor signaling pathway • intracellular signal transduction • cAMP/PKA signal transduction • intracellular signaling cassette • regulation of localization • regulation of calcium ion transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • cellular localization • regulation of calcium ion transport into cytosol • transport • monoatomic ion transmembrane transport • positive regulation of biological process • regulation of monoatomic ion transmembrane transport • calcium ion transport • metal ion transport • monoatomic cation transmembrane transport • regulation of calcium ion transmembrane transport • localization • positive regulation of monoatomic ion transport • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • regulation of biological quality • monoatomic cation transport • regulation of metal ion transport • positive regulation of cellular process • calcium ion transmembrane import into cytosol • regulation of transport • regulation of monoatomic ion transport • positive regulation of cytosolic calcium ion concentration • establishment of localization • transmembrane transport • positive regulation of calcium ion transport into cytosol • regulation of transmembrane transport • positive regulation of transport • regulation of cellular localization • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • calcium ion transport into cytosol • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of cAMP/PKA signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • regulation of signaling • positive regulation of intracellular signal transduction • regulation of cAMP/PKA signal transduction • regulation of response to stimulus • regulation of cell communication • positive regulation of signaling • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • positive regulation of small GTPase mediated signal transduction • multicellular organism development • development of primary sexual characteristics • sex differentiation • anatomical structure development • female sex differentiation • development of primary female sexual characteristics • regulation of inositol phosphate biosynthetic process • alcohol metabolic process • positive regulation of phosphate metabolic process • inositol phosphate metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • phosphate-containing compound metabolic process • polyol biosynthetic process • small molecule metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • regulation of biosynthetic process • carbohydrate metabolic process • polyol metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • carbohydrate biosynthetic process • primary metabolic process • positive regulation of inositol phosphate biosynthetic process • biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • metabolic process • regulation of phosphorus metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • response to lipid • response to estradiol • negative regulation of response to reactive oxygen species • negative regulation of response to stimulus • negative regulation of biological process • response to reactive oxygen species • response to oxidative stress • regulation of response to reactive oxygen species • regulation of response to stress • regulation of response to oxidative stress • negative regulation of response to oxidative stress • cell surface • membrane microdomain • membrane raft • plasma membrane raft • plasma membrane region • caveola • receptor complex • endosome • intracellular vesicle • cytoplasmic vesicle • cell-cell junction • apical junction complex • bicellular tight junction • tight junction • anchoring junction • cell junction • signaling receptor binding • hormone activity • molecular function activator activity • molecular function regulator activity • neuropeptide hormone activity • neuropeptide activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • peptide hormone receptor binding • hormone receptor binding • vasoactive intestinal polypeptide receptor binding • type 2 vasoactive intestinal polypeptide receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • pituitary adenylate cyclase activating polypeptide activity • type 1 vasoactive intestinal polypeptide receptor binding • neuropeptide signaling pathway • chemokine (C-C motif) ligand 5 production • positive regulation of chemokine (C-C motif) ligand 5 production • positive regulation of macromolecule biosynthetic process • cytokine production • regulation of cytokine production • regulation of multicellular organismal process • positive regulation of macromolecule metabolic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of chemokine production • regulation of gene expression • positive regulation of gene expression • chemokine production • positive regulation of chemokine production • positive regulation of multicellular organismal process • regulation of chemokine (C-C motif) ligand 5 production • regulation of macromolecule biosynthetic process • macromolecule metabolic process • positive regulation of cytokine production • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • multi-multicellular organism process • female pregnancy • multi-organism reproductive process • positive regulation of molecular function • regulation of molecular function • positive regulation of hydrolase activity • regulation of catalytic activity • regulation of hydrolase activity • positive regulation of catalytic activity • regulation of GTPase activity • positive regulation of GTPase activity • negative regulation of cellular process • negative regulation of cell cycle • cell cycle • regulation of cell cycle • cell-cell signaling • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • regulation of G protein-coupled receptor signaling pathway • regulation of protein localization • macromolecule localization • intracellular protein localization • positive regulation of adenylate cyclase activity • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • positive regulation of lyase activity • regulation of protein modification process • positive regulation of phosphorylation • regulation of protein phosphorylation • positive regulation of protein metabolic process • regulation of transferase activity • positive regulation of protein modification process • protein metabolic process • positive regulation of protein kinase activity • protein modification process • positive regulation of protein phosphorylation • protein phosphorylation • phosphorylation • regulation of protein metabolic process • regulation of protein kinase activity • positive regulation of kinase activity • regulation of kinase activity • macromolecule modification • regulation of phosphorylation • regulation of hormone secretion • nitrogen compound transport • regulation of peptide secretion • positive regulation of secretion by cell • hormone secretion • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • signal release • regulation of peptide hormone secretion • positive regulation of peptide secretion • growth hormone secretion • secretion • regulation of hormone levels • regulation of growth hormone secretion • regulation of peptide transport • positive regulation of peptide hormone secretion • export from cell • regulation of secretion • peptide transport • positive regulation of growth hormone secretion • peptide hormone secretion • hormone transport • positive regulation of DNA-templated transcription • RNA metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • establishment of protein localization • protein localization to extracellular region • establishment of protein localization to extracellular region • protein secretion • protein transport • insulin secretion • plasma membrane bounded cell projection organization • cell projection organization • cell development • neuron projection development • nervous system development • cellular component organization • generation of neurons • neurogenesis • neuron differentiation • neuron development • cellular component organization or biogenesis • system development • somatodendritic compartment • cell body • perikaryon • neuronal cell body • cell projection • neuron projection • plasma membrane bounded cell projection • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • response to endogenous stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • synapse • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• FnI-like domain • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• FnI-like domain • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	L
Protein	PACAP27
UniProt	P18509
Sequence	>9P94_nogp_Chain_L H S D G I F T D S Y S R Y R K Q M A V K K Y L A A V L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P41586
Sequence	>9P94_nogp_Chain_R D C I F K K E Q A M C L E K I Q R A N E P G C P G M W D N I T C W K P A H V G E M V L V S C P E L F R I F N P D Q D M G V V S R N C T E D G W S E P F P H Y F D A C G F D E Y Q D Y Y Y L S V K A L Y T V G Y S T S L V T L T T A M V I L C R F R K L H C T R N F I H M N L F V S F M L R A I S V F I K D W I L Y A E S T V E C K A V M V F F H Y C V V S N Y F W L F I E G L Y L F T L L V E T F F P E R R Y F Y W Y T I I G W G T P T V C V T V W A T L R L Y F D D T G C W D M N D S T A L W W V I K G P V V G S I M V N F V L F I G I I V I L V Q K L Q S P S I Y L R L A R S T L L L I P L F G I H Y T V F A F S P E N V S K R E R L V F E L G L G S F Q G F V V A V L Y C F L N G E V Q A E I K R K W R S W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6P9Y	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-	Gs/β1/γ2	3.01	2020-02-05	doi.org/10.1016/j.molcel.2020.01.012
	6P9Y (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-		3.01	2020-02-05	doi.org/10.1016/j.molcel.2020.01.012
	6LPB	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-	Gs/β1/γ1	3.9	2020-03-11	doi.org/10.1038/s41594-020-0386-8
	6LPB (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-		3.9	2020-03-11	doi.org/10.1038/s41594-020-0386-8
	6M1H	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	Maxadilan	-	Gs/β1/γ2	3.6	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	6M1H (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	Maxadilan	-		3.6	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	6M1I	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-	Gs/β1/γ2	3.5	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	6M1I (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-		3.5	2020-03-11	doi.org/10.1038/s41422-020-0280-2
	8E3X	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-	Gs/β1/γ2	2.3	2022-11-23	doi.org/10.1038/s41467-022-34629-3
	8E3X (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-		2.3	2022-11-23	doi.org/10.1038/s41467-022-34629-3
	9P92	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	VIP	-	Gs/β1/γ2	3.8	2025-11-19	10.1073/pnas.2521157122
	9P92 (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	VIP	-		3.8	2025-11-19	10.1073/pnas.2521157122
	9P93	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	VIP	-	Gs/β1/γ2	3.2	2025-11-19	10.1073/pnas.2521157122
	9P93 (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	VIP	-		3.2	2025-11-19	10.1073/pnas.2521157122
	9P94	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-	Gs/β1/γ2	3	2025-11-19	10.1073/pnas.2521157122
	9P94 (No Gprot)	B1	Peptide	VIP and PACAP	PAC₁	Homo sapiens	PACAP27	-		3	2025-11-19	10.1073/pnas.2521157122

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