psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W151	2.28	Yes	Yes	3	0	5
2	L:L:?1	R:R:D155	19.03	Yes	Yes	3	0	8
3	L:L:?1	R:R:V156	7.96	Yes	Yes	3	0	6
4	L:L:?1	R:R:S159	14.04	Yes	No	3	0	7
5	L:L:?1	R:R:I163	3.81	Yes	No	0	0	8
6	L:L:?1	R:R:L229	4.62	Yes	Yes	3	0	4
7	L:L:?1	R:R:V235	3.98	Yes	Yes	3	0	6
8	L:L:?1	R:R:S242	2.01	Yes	Yes	3	0	6
9	L:L:?1	R:R:W336	12.17	Yes	Yes	3	0	8
10	L:L:?1	R:R:F339	6.51	Yes	Yes	3	0	7
11	L:L:?1	R:R:F340	17.08	Yes	Yes	3	0	7
12	L:L:?1	R:R:N343	1.83	Yes	Yes	3	0	7
13	L:L:?1	R:R:Y370	3.13	Yes	Yes	3	0	7
14	M:M:?1	S:S:W151	3.8	Yes	Yes	1	0	5
15	M:M:?1	S:S:D155	17.22	Yes	Yes	1	0	8
16	M:M:?1	S:S:V156	9.95	Yes	Yes	1	0	6
17	M:M:?1	S:S:S159	12.03	Yes	No	1	0	7
18	M:M:?1	S:S:T160	2.95	Yes	No	1	0	7
19	M:M:?1	S:S:L229	8.32	Yes	Yes	1	0	4
20	M:M:?1	S:S:V235	3.98	Yes	Yes	1	0	6
21	M:M:?1	S:S:G238	2.28	Yes	No	0	0	6
22	M:M:?1	S:S:S239	3.01	Yes	Yes	1	0	6
23	M:M:?1	S:S:S242	6.02	Yes	No	1	0	6
24	M:M:?1	S:S:W336	13.69	Yes	Yes	1	0	8
25	M:M:?1	S:S:F339	8.95	Yes	Yes	1	0	7
26	M:M:?1	S:S:F340	17.08	Yes	Yes	1	0	7
27	M:M:?1	S:S:N343	4.58	Yes	Yes	1	0	7
28	M:M:?1	S:S:Y370	2.35	Yes	Yes	1	0	7
29	P:P:L69	P:P:L71	2.77	No	No	0	7	3
30	P:P:E73	P:P:H70	7.39	No	No	0	3	3
31	P:P:I135	P:P:K74	2.91	Yes	No	0	5	6
32	P:P:N75	P:P:W76	5.65	No	No	0	5	4
33	P:P:L79	P:P:W76	2.28	No	No	0	4	4
34	P:P:I85	P:P:T81	1.52	Yes	No	2	6	6
35	P:P:M132	P:P:T81	4.52	No	No	2	6	6
36	P:P:T81	P:P:W367	12.13	No	Yes	2	6	6
37	P:P:L87	P:P:V83	2.98	No	No	0	4	4
38	P:P:T88	P:P:V84	1.59	Yes	Yes	2	7	7
39	P:P:M128	P:P:V84	1.52	Yes	Yes	2	8	7
40	P:P:V84	P:P:W367	4.9	Yes	Yes	2	7	6
41	P:P:A371	P:P:V84	5.09	No	Yes	0	4	7
42	P:P:G124	P:P:I85	1.76	Yes	Yes	2	6	6
43	P:P:I85	P:P:M128	4.37	Yes	Yes	2	6	8
44	P:P:I85	P:P:P129	1.69	Yes	No	2	6	8
45	P:P:I85	P:P:M132	2.92	Yes	No	2	6	6
46	P:P:I85	P:P:W367	3.52	Yes	Yes	2	6	6
47	P:P:I86	P:P:L87	2.85	No	No	0	4	4
48	P:P:A374	P:P:L87	1.58	No	No	0	6	4
49	P:P:G124	P:P:T88	1.82	Yes	Yes	2	6	7
50	P:P:M128	P:P:T88	9.03	Yes	Yes	2	8	7
51	P:P:S373	P:P:T88	1.6	Yes	Yes	0	9	7
52	P:P:A374	P:P:T88	3.36	No	Yes	0	6	7
53	P:P:A90	P:P:G91	1.95	No	No	0	4	8
54	P:P:G91	P:P:P377	4.06	No	Yes	0	8	9
55	P:P:A117	P:P:N92	4.69	No	No	0	9	9
56	P:P:D120	P:P:N92	9.42	Yes	No	0	9	9
57	P:P:N92	P:P:P377	11.4	No	Yes	0	9	9
58	P:P:I93	P:P:M121	2.92	No	No	0	3	7
59	P:P:L94	P:P:M97	2.83	No	No	0	6	4
60	P:P:F391	P:P:L94	10.96	Yes	No	0	6	6
61	P:P:A117	P:P:V95	3.39	No	Yes	0	9	9
62	P:P:P377	P:P:V95	3.53	Yes	Yes	0	9	9
63	P:P:V95	P:P:Y380	2.52	Yes	Yes	0	9	9
64	P:P:F391	P:P:V95	5.24	Yes	Yes	0	6	9
65	P:P:I96	P:P:M114	2.92	Yes	No	0	6	5
66	P:P:A117	P:P:I96	1.62	No	Yes	0	9	6
67	P:P:I118	P:P:I96	5.89	No	Yes	0	6	6
68	P:P:I96	P:P:M121	2.92	Yes	No	0	6	7
69	P:P:M97	P:P:Y394	4.79	No	Yes	0	4	4
70	P:P:A98	P:P:L105	1.58	No	Yes	7	7	8
71	P:P:A98	P:P:Y387	2.67	No	Yes	7	7	8
72	P:P:M114	P:P:V99	6.09	No	No	0	5	7
73	P:P:V99	P:P:Y387	3.79	No	Yes	0	7	8
74	P:P:L101	P:P:S100	1.5	No	No	0	5	1
75	P:P:L101	P:P:Y394	7.03	No	Yes	0	5	4
76	P:P:E102	P:P:L105	5.3	Yes	Yes	7	6	8
77	P:P:A390	P:P:E102	4.53	No	Yes	7	7	6
78	P:P:E102	P:P:R393	5.82	Yes	No	7	6	4
79	P:P:E102	P:P:Y394	2.24	Yes	Yes	7	6	4
80	P:P:K104	P:P:T386	6.01	No	No	0	6	6
81	P:P:L105	P:P:N110	2.75	Yes	Yes	7	8	9
82	P:P:L105	P:P:T386	5.9	Yes	No	0	8	6
83	P:P:L105	P:P:Y387	9.38	Yes	Yes	7	8	8
84	P:P:Q106	P:P:Y111	5.64	No	Yes	0	7	4
85	P:P:N107	P:P:T109	5.85	No	No	7	7	8
86	P:P:N107	P:P:N110	9.54	No	Yes	7	7	9
87	P:P:N110	P:P:T109	2.92	Yes	No	7	9	8
88	P:P:N110	P:P:Y387	6.98	Yes	Yes	7	9	8
89	P:P:M114	P:P:Y111	2.39	No	Yes	0	5	4
90	P:P:R189	P:P:Y111	15.43	No	Yes	9	4	4
91	P:P:A192	P:P:Y111	4	No	Yes	0	7	4
92	P:P:F193	P:P:Y111	5.16	No	Yes	9	4	4
93	P:P:A168	P:P:F112	2.77	No	Yes	0	7	8
94	P:P:F112	P:P:I169	8.79	Yes	No	2	8	9
95	P:P:D172	P:P:F112	4.78	No	Yes	2	9	8
96	P:P:F112	P:P:K195	6.2	Yes	No	2	8	6
97	P:P:F112	P:P:I196	7.54	Yes	No	0	8	8
98	P:P:L113	P:P:Y380	9.38	No	Yes	0	8	9
99	P:P:I118	P:P:S115	1.55	No	Yes	0	6	9
100	P:P:H165	P:P:S115	9.76	Yes	Yes	2	8	9
101	P:P:I196	P:P:S115	9.29	No	Yes	0	8	9
102	P:P:S115	P:P:W200	4.94	Yes	Yes	2	9	9
103	P:P:D120	P:P:L116	4.07	Yes	No	0	9	9
104	P:P:H165	P:P:L116	6.43	Yes	No	0	8	9
105	P:P:L116	P:P:L166	2.77	No	Yes	0	9	8
106	P:P:A119	P:P:S162	1.71	No	No	0	8	9
107	P:P:A119	P:P:W200	2.59	No	Yes	0	8	9
108	P:P:D120	P:P:S162	4.42	Yes	No	0	9	9
109	P:P:D120	P:P:S373	10.31	Yes	Yes	0	9	9
110	P:P:D120	P:P:N376	9.42	Yes	No	0	9	9
111	P:P:F158	P:P:L122	13.4	Yes	No	0	7	7
112	P:P:G124	P:P:L123	1.71	Yes	Yes	0	6	7
113	P:P:L123	P:P:V127	7.45	Yes	Yes	0	7	8
114	P:P:F158	P:P:L123	4.87	Yes	Yes	0	7	7
115	P:P:L123	P:P:S159	3	Yes	No	0	7	7
116	P:P:L123	P:P:S373	1.5	Yes	Yes	0	7	9
117	P:P:G124	P:P:M128	5.24	Yes	Yes	2	6	8
118	P:P:L126	P:P:V127	1.49	No	Yes	2	5	8
119	P:P:L126	P:P:L154	4.15	No	Yes	2	5	5
120	P:P:F158	P:P:L126	2.44	Yes	No	2	7	5
121	P:P:V127	P:P:W151	4.9	Yes	Yes	2	8	5
122	P:P:L154	P:P:V127	2.98	Yes	Yes	2	5	8
123	P:P:D155	P:P:V127	13.15	Yes	Yes	2	8	8
124	P:P:M128	P:P:P129	1.68	Yes	No	2	8	8
125	P:P:M128	P:P:W367	3.49	Yes	Yes	2	8	6
126	P:P:M128	P:P:Y370	3.59	Yes	Yes	2	8	7
127	P:P:V130	P:P:W141	3.68	No	Yes	2	4	7
128	P:P:L143	P:P:V130	2.98	Yes	No	2	5	4
129	P:P:V130	P:P:W151	6.13	No	Yes	2	4	5
130	P:P:S131	P:P:W151	3.71	No	Yes	2	7	5
131	P:P:S131	P:P:W367	4.94	No	Yes	2	7	6
132	P:P:S131	P:P:Y370	8.9	No	Yes	2	7	7
133	P:P:M132	P:P:W367	2.33	No	Yes	2	6	6
134	P:P:L133	P:P:P142	9.85	No	Yes	0	4	3
135	P:P:I135	P:P:T134	1.52	Yes	No	2	5	5
136	P:P:T134	P:P:W141	2.43	No	Yes	2	5	7
137	P:P:P142	P:P:T134	6.99	Yes	No	2	3	5
138	P:P:I135	P:P:Y139	6.04	Yes	No	2	5	3
139	P:P:I135	P:P:N363	8.5	Yes	Yes	2	5	4
140	P:P:P142	P:P:Y137	4.17	Yes	No	0	3	4
141	P:P:N363	P:P:Y139	12.79	Yes	No	2	4	3
142	P:P:G225	P:P:R140	4.5	No	No	0	3	4
143	P:P:P142	P:P:W141	6.76	Yes	Yes	2	3	7
144	P:P:L143	P:P:W141	6.83	Yes	Yes	2	5	7
145	P:P:C148	P:P:W141	11.75	Yes	Yes	2	9	7
146	P:P:W141	P:P:W151	12.18	Yes	Yes	2	7	5
147	P:P:F222	P:P:W141	4.01	No	Yes	2	2	7
148	P:P:C227	P:P:W141	3.92	Yes	Yes	2	9	7
149	P:P:L143	P:P:P142	3.28	Yes	Yes	2	5	3
150	P:P:L143	P:P:P144	4.93	Yes	No	0	5	7
151	P:P:L147	P:P:V150	2.98	No	No	0	5	4
152	P:P:C148	P:P:I152	3.27	Yes	Yes	2	9	5
153	P:P:C148	P:P:V221	3.42	Yes	Yes	2	9	3
154	P:P:C148	P:P:F222	4.19	Yes	No	2	9	2
155	P:P:C148	P:P:C227	7.28	Yes	Yes	2	9	9
156	P:P:A149	P:P:V221	5.09	No	Yes	0	6	3
157	P:P:L154	P:P:V150	1.49	Yes	No	0	5	4
158	P:P:I152	P:P:W151	2.35	Yes	Yes	2	5	5
159	P:P:D155	P:P:W151	3.35	Yes	Yes	2	8	5
160	P:P:C227	P:P:W151	5.22	Yes	Yes	2	9	5
161	P:P:W151	U:U:?1	2.28	Yes	Yes	2	5	0
162	P:P:I152	P:P:V156	1.54	Yes	Yes	2	5	6
163	P:P:I152	P:P:I210	2.94	Yes	Yes	2	5	6
164	P:P:I152	P:P:V221	3.07	Yes	Yes	2	5	3
165	P:P:C227	P:P:I152	3.27	Yes	Yes	2	9	5
166	P:P:I152	P:P:L229	5.71	Yes	No	2	5	4
167	P:P:L154	P:P:Y153	2.34	Yes	Yes	2	5	6
168	P:P:L157	P:P:Y153	9.38	Yes	Yes	2	6	6
169	P:P:S207	P:P:Y153	7.63	Yes	Yes	2	7	6
170	P:P:I210	P:P:Y153	4.84	Yes	Yes	2	6	6
171	P:P:P211	P:P:Y153	5.56	No	Yes	2	5	6
172	P:P:D155	P:P:Y370	12.64	Yes	Yes	2	8	7
173	P:P:D155	U:U:?1	12.69	Yes	Yes	2	8	0
174	P:P:S207	P:P:V156	1.62	Yes	Yes	2	7	6
175	P:P:I210	P:P:V156	4.61	Yes	Yes	2	6	6
176	P:P:V156	U:U:?1	9.95	Yes	Yes	2	6	0
177	P:P:F158	P:P:L157	2.44	Yes	Yes	2	7	6
178	P:P:L157	P:P:W200	2.28	Yes	Yes	2	6	9
179	P:P:L157	P:P:S203	1.5	Yes	Yes	2	6	8
180	P:P:L157	P:P:V204	2.98	Yes	No	2	6	4
181	P:P:L157	P:P:S207	9.01	Yes	Yes	2	6	7
182	P:P:F158	P:P:W200	3.01	Yes	Yes	2	7	9
183	P:P:S159	U:U:?1	12.03	No	Yes	0	7	0
184	P:P:I163	P:P:T160	1.52	Yes	Yes	2	8	7
185	P:P:M164	P:P:T160	3.01	Yes	Yes	2	6	7
186	P:P:S203	P:P:T160	4.8	Yes	Yes	2	8	7
187	P:P:I206	P:P:T160	1.52	Yes	Yes	2	6	7
188	P:P:S242	P:P:T160	1.6	Yes	Yes	2	6	7
189	P:P:A161	P:P:W200	7.78	No	Yes	0	8	9
190	P:P:A161	P:P:S203	3.42	No	Yes	0	8	8
191	P:P:F243	P:P:I163	2.51	Yes	Yes	2	8	8
192	P:P:I163	P:P:P246	5.08	Yes	Yes	0	8	9
193	P:P:A247	P:P:I163	1.62	No	Yes	0	6	8
194	P:P:I163	P:P:M250	2.92	Yes	Yes	2	8	8
195	P:P:F332	P:P:I163	8.79	Yes	Yes	2	9	8
196	P:P:M164	P:P:V199	1.52	Yes	Yes	2	6	6
197	P:P:M164	P:P:S203	4.6	Yes	Yes	2	6	8
198	P:P:M164	P:P:P246	3.35	Yes	Yes	0	6	9
199	P:P:H165	P:P:V199	9.69	Yes	Yes	2	8	6
200	P:P:H165	P:P:W200	11.64	Yes	Yes	2	8	9
201	P:P:L166	P:P:M250	7.07	Yes	Yes	2	8	8
202	P:P:L166	P:P:V328	1.49	Yes	Yes	2	8	8
203	P:P:F329	P:P:L166	6.09	Yes	Yes	2	8	8
204	P:P:F332	P:P:L166	6.09	Yes	Yes	2	9	8
205	P:P:C167	P:P:P246	1.88	No	Yes	0	6	9
206	P:P:C167	P:P:I249	3.27	No	No	0	6	6
207	P:P:C167	P:P:M250	3.24	No	Yes	0	6	8
208	P:P:A168	P:P:V199	1.7	No	Yes	0	7	6
209	P:P:I169	P:P:L325	2.85	No	Yes	2	9	8
210	P:P:F329	P:P:I169	3.77	Yes	No	2	8	9
211	P:P:S170	P:P:T253	6.4	No	No	0	9	5
212	P:P:F329	P:P:S170	6.61	Yes	No	0	8	9
213	P:P:L171	P:P:V175	1.49	No	No	0	6	5
214	P:P:D172	P:P:K195	6.91	No	No	2	9	6
215	P:P:E318	P:P:R173	10.47	No	Yes	0	8	9
216	P:P:L325	P:P:R173	3.64	Yes	Yes	0	8	9
217	P:P:V175	P:P:Y174	5.05	No	No	0	5	8
218	P:P:T257	P:P:Y174	4.99	No	No	0	9	8
219	P:P:I177	P:P:S260	4.64	No	No	0	9	6
220	P:P:I177	P:P:L261	4.28	No	No	0	9	8
221	P:P:N187	P:P:S184	2.98	No	No	0	6	6
222	P:P:F186	S:S:Q396	23.42	No	No	0	4	4
223	P:P:F186	S:S:Q398	4.68	No	No	0	4	4
224	P:P:N187	S:S:S392	4.47	No	No	0	6	3
225	P:P:F193	P:P:R189	13.9	No	No	9	4	4
226	P:P:R189	S:S:Q396	17.52	No	No	0	4	4
227	P:P:T190	S:S:S392	4.8	No	No	0	5	3
228	P:P:T190	S:S:Q396	5.67	No	No	0	5	4
229	P:P:K191	P:P:K195	2.87	No	No	0	6	6
230	P:P:L194	S:S:I395	2.85	No	No	0	3	6
231	P:P:S203	P:P:V199	1.62	Yes	Yes	2	8	6
232	P:P:I202	P:P:T201	3.04	No	No	0	5	4
233	P:P:S207	P:P:V204	1.62	Yes	No	2	7	4
234	P:P:G205	S:S:N75	1.7	No	Yes	0	4	5
235	P:P:G205	S:S:L79	3.42	No	Yes	0	4	4
236	P:P:I206	P:P:V241	3.07	Yes	No	2	6	4
237	P:P:I206	P:P:S242	1.55	Yes	Yes	2	6	6
238	P:P:M208	P:P:P209	1.68	Yes	No	6	4	7
239	P:P:M208	S:S:K74	5.76	Yes	Yes	6	4	6
240	P:P:M208	S:S:N75	5.61	Yes	Yes	6	4	5
241	P:P:M208	S:S:A78	3.22	Yes	No	0	4	6
242	P:P:P209	S:S:L71	3.28	No	Yes	6	7	3
243	P:P:P209	S:S:N75	8.15	No	Yes	6	7	5
244	P:P:I210	P:P:P211	3.39	Yes	No	2	6	5
245	P:P:V212	S:S:L71	5.96	No	Yes	6	5	3
246	P:P:V212	S:S:K74	1.52	No	Yes	6	5	6
247	P:P:D217	P:P:F213	7.17	No	No	6	6	4
248	P:P:F213	P:P:K220	12.41	No	Yes	6	4	3
249	P:P:F213	S:S:L71	9.74	No	Yes	6	4	3
250	P:P:D217	P:P:S219	5.89	No	No	6	6	3
251	P:P:D217	P:P:K220	5.53	No	Yes	6	6	3
252	P:P:D218	P:P:F222	2.39	No	No	0	5	2
253	P:P:K220	P:P:S219	1.53	Yes	No	6	3	3
254	P:P:D231	P:P:K220	13.83	No	Yes	6	5	3
255	P:P:F234	P:P:K220	6.2	No	Yes	6	7	3
256	P:P:C227	P:P:V221	1.71	Yes	Yes	2	9	3
257	P:P:K223	P:P:L228	5.64	No	No	0	3	4
258	P:P:A230	P:P:K223	3.21	No	No	0	3	3
259	P:P:L228	P:P:S226	4.5	No	No	0	4	4
260	P:P:L229	P:P:V235	2.98	No	No	2	4	6
261	P:P:L229	U:U:?1	4.62	No	Yes	2	4	0
262	P:P:D231	P:P:N233	4.04	No	No	0	5	3
263	P:P:D231	P:P:F234	8.36	No	No	6	5	7
264	P:P:D232	P:P:V347	8.76	No	No	0	4	5
265	P:P:D232	P:P:K350	4.15	No	No	0	4	1
266	P:P:F234	S:S:Q72	4.68	No	No	0	7	1
267	P:P:V235	P:P:V347	3.21	No	No	0	6	5
268	P:P:V235	U:U:?1	3.98	No	Yes	2	6	0
269	P:P:I344	P:P:L236	2.85	No	No	0	5	6
270	P:P:L236	P:P:V347	5.96	No	No	0	6	5
271	P:P:G238	P:P:I237	3.53	No	No	0	6	4
272	P:P:G238	P:P:S242	1.86	No	Yes	0	6	6
273	P:P:F340	P:P:S239	5.28	Yes	No	2	7	6
274	P:P:I344	P:P:S239	3.1	No	No	0	5	6
275	P:P:S239	U:U:?1	3.01	No	Yes	2	6	0
276	P:P:F240	P:P:F244	10.72	No	Yes	0	4	5
277	P:P:S242	P:P:V241	3.23	Yes	No	2	6	4
278	P:P:S242	U:U:?1	4.01	Yes	Yes	2	6	0
279	P:P:F243	P:P:F244	8.57	Yes	Yes	2	8	5
280	P:P:F243	P:P:F332	3.22	Yes	Yes	2	8	9
281	P:P:F243	P:P:W336	4.01	Yes	Yes	2	8	8
282	P:P:C337	P:P:F243	2.79	No	Yes	0	6	8
283	P:P:F243	P:P:F340	20.36	Yes	Yes	2	8	7
284	P:P:F243	U:U:?1	1.63	Yes	Yes	2	8	0
285	P:P:F244	P:P:F340	2.14	Yes	Yes	2	5	7
286	P:P:F244	P:P:I341	2.51	Yes	No	0	5	6
287	P:P:I245	P:P:P246	5.08	No	Yes	0	5	9
288	P:P:A247	P:P:V333	1.7	No	No	0	6	6
289	P:P:I252	P:P:T248	1.52	No	No	0	5	3
290	P:P:I249	P:P:T253	1.52	No	No	0	6	5
291	P:P:F329	P:P:M250	6.22	Yes	Yes	2	8	8
292	P:P:M250	P:P:V333	1.52	Yes	No	0	8	6
293	P:P:F255	P:P:V251	2.62	No	No	0	1	5
294	P:P:I252	P:P:L256	2.85	No	No	0	5	5
295	P:P:F255	P:P:Y254	5.16	No	No	0	1	9
296	P:P:G326	P:P:Y254	7.24	No	No	2	6	9
297	P:P:F329	P:P:Y254	6.19	Yes	No	2	8	9
298	P:P:F255	P:P:I258	2.51	No	No	0	1	5
299	P:P:K259	P:P:Q262	4.07	No	No	0	4	6
300	P:P:E264	P:P:L261	3.98	No	No	0	7	8
301	P:P:A265	P:P:I315	6.5	No	No	0	5	5
302	P:P:M312	P:P:T311	3.01	No	No	0	4	4
303	P:P:K323	P:P:Q319	10.85	No	No	0	7	5
304	P:P:F383	P:P:V324	2.62	Yes	No	0	7	8
305	P:P:L325	P:P:V328	1.49	Yes	Yes	2	8	8
306	P:P:F329	P:P:L325	7.31	Yes	Yes	2	8	8
307	P:P:F329	P:P:G326	3.01	Yes	No	2	8	6
308	P:P:I327	P:P:L331	2.85	No	No	0	6	6
309	P:P:I327	P:P:V379	3.07	No	Yes	2	6	8
310	P:P:F383	P:P:I327	2.51	Yes	No	2	7	6
311	P:P:F329	P:P:V328	2.62	Yes	Yes	2	8	8
312	P:P:N376	P:P:V328	4.43	No	Yes	0	9	8
313	P:P:V328	P:P:V379	1.6	Yes	Yes	2	8	8
314	P:P:F330	P:P:V334	10.49	No	No	0	5	5
315	P:P:L331	P:P:V375	7.45	No	No	0	6	6
316	P:P:F332	P:P:W336	9.02	Yes	Yes	2	9	8
317	P:P:F332	U:U:?1	1.63	Yes	Yes	2	9	0
318	P:P:C337	P:P:V333	1.71	No	No	0	6	6
319	P:P:G369	P:P:M335	1.75	No	No	0	7	8
320	P:P:M335	P:P:S372	4.6	No	No	0	8	9
321	P:P:M335	P:P:V375	3.04	No	No	0	8	6
322	P:P:F339	P:P:W336	8.02	Yes	Yes	2	7	8
323	P:P:F340	P:P:W336	5.01	Yes	Yes	2	7	8
324	P:P:G369	P:P:W336	12.67	No	Yes	0	7	8
325	P:P:W336	P:P:Y370	3.86	Yes	Yes	2	8	7
326	P:P:S372	P:P:W336	4.94	No	Yes	0	9	8
327	P:P:W336	U:U:?1	15.21	Yes	Yes	2	8	0
328	P:P:C337	P:P:P338	1.88	No	No	0	6	9
329	P:P:F365	P:P:P338	7.22	Yes	No	0	5	9
330	P:P:F339	P:P:F340	10.72	Yes	Yes	2	7	7
331	P:P:F339	P:P:N343	9.67	Yes	No	0	7	7
332	P:P:F339	P:P:V366	2.62	Yes	Yes	2	7	6
333	P:P:F339	U:U:?1	6.51	Yes	Yes	2	7	0
334	P:P:F340	U:U:?1	23.59	Yes	Yes	2	7	0
335	P:P:I341	P:P:T342	1.52	No	No	0	6	5
336	P:P:L362	P:P:T342	2.95	Yes	No	0	3	5
337	P:P:F365	P:P:T342	6.49	Yes	No	0	5	5
338	P:P:L362	P:P:N343	6.87	Yes	No	0	3	7
339	P:P:A346	P:P:E355	3.02	No	No	0	4	3
340	P:P:A346	P:P:I358	1.62	No	No	0	4	4
341	P:P:C349	P:P:C353	7.28	No	No	10	3	3
342	P:P:C349	P:P:E355	1.52	No	No	10	3	3
343	P:P:E351	P:P:K350	13.5	No	No	0	5	1
344	P:P:C353	P:P:S352	1.72	No	No	0	3	2
345	P:P:C353	P:P:E355	1.52	No	No	10	3	3
346	P:P:D356	P:P:N354	12.12	No	No	0	2	1
347	P:P:N354	P:P:V357	4.43	No	No	0	1	5
348	P:P:L361	P:P:V357	2.98	No	No	0	4	5
349	P:P:I358	P:P:L362	2.85	No	Yes	0	4	3
350	P:P:G359	P:P:L362	3.42	No	Yes	0	2	3
351	P:P:F365	P:P:L361	4.87	Yes	No	0	5	4
352	P:P:N363	P:P:V366	2.96	Yes	Yes	2	4	6
353	P:P:N363	P:P:W367	3.39	Yes	Yes	2	4	6
354	P:P:F365	P:P:V364	5.24	Yes	No	0	5	4
355	P:P:I368	P:P:V364	3.07	No	No	0	7	4
356	P:P:V366	P:P:W367	2.45	Yes	Yes	2	6	6
357	P:P:V366	P:P:Y370	11.36	Yes	Yes	2	6	7
358	P:P:W367	P:P:Y370	11.58	Yes	Yes	2	6	7
359	P:P:G369	P:P:I368	1.76	No	No	0	7	7
360	P:P:Y370	U:U:?1	3.91	Yes	Yes	2	7	0
361	P:P:S372	P:P:S373	1.63	No	Yes	0	9	9
362	P:P:N376	P:P:P377	4.89	No	Yes	0	9	9
363	P:P:L378	P:P:L382	4.15	No	No	0	6	5
364	P:P:V379	P:P:Y380	7.57	Yes	Yes	0	8	9
365	P:P:F383	P:P:V379	2.62	Yes	Yes	2	7	8
366	P:P:Y380	P:P:Y387	11.91	Yes	Yes	0	9	8
367	P:P:L382	P:P:T381	2.95	No	No	0	5	7
368	P:P:F391	P:P:T381	5.19	Yes	No	0	6	7
369	P:P:F383	P:P:L382	4.87	Yes	No	0	7	5
370	P:P:N384	P:P:T386	8.77	No	No	0	9	6
371	P:P:N384	P:P:Y387	10.47	No	Yes	0	9	8
372	P:P:F391	P:P:Y387	2.06	Yes	Yes	0	6	8
373	P:P:A390	P:P:R393	2.77	No	No	7	7	4
374	P:P:A390	P:P:Y394	2.67	No	Yes	7	7	4
375	P:P:C397	P:P:Q396	1.53	No	No	0	8	4
376	R:R:K74	R:R:L71	4.23	No	No	0	6	3
377	R:R:E73	R:R:Q72	11.47	No	No	0	3	1
378	R:R:N75	S:S:V212	2.96	No	No	0	5	5
379	R:R:L79	R:R:V83	1.49	Yes	No	0	4	4
380	R:R:L79	S:S:V204	1.49	Yes	No	0	4	4
381	R:R:L79	S:S:G205	1.71	Yes	No	0	4	4
382	R:R:M132	R:R:T81	7.53	No	No	0	6	6
383	R:R:T81	R:R:W367	16.98	No	Yes	0	6	6
384	R:R:A82	R:R:M132	3.22	No	No	0	3	6
385	R:R:I86	R:R:V83	3.07	No	No	0	4	4
386	R:R:L87	R:R:V83	2.98	No	No	0	4	4
387	R:R:M128	R:R:V84	3.04	Yes	No	3	8	7
388	R:R:V84	R:R:W367	4.9	No	Yes	3	7	6
389	R:R:A371	R:R:V84	3.39	No	No	0	4	7
390	R:R:I85	R:R:M128	5.83	Yes	Yes	3	6	8
391	R:R:I85	R:R:P129	6.77	Yes	No	3	6	8
392	R:R:I85	R:R:M132	2.92	Yes	No	0	6	6
393	R:R:I85	R:R:W367	3.52	Yes	Yes	3	6	6
394	R:R:A374	R:R:L87	1.58	No	No	0	6	4
395	R:R:G124	R:R:T88	1.82	No	Yes	3	6	7
396	R:R:M128	R:R:T88	6.02	Yes	Yes	3	8	7
397	R:R:S373	R:R:T88	3.2	Yes	Yes	3	9	7
398	R:R:A374	R:R:T88	1.68	No	Yes	0	6	7
399	R:R:A90	R:R:I89	1.62	No	No	0	4	5
400	R:R:A90	R:R:G91	1.95	No	No	0	4	8
401	R:R:G91	R:R:P377	4.06	No	Yes	0	8	9
402	R:R:A117	R:R:N92	4.69	No	No	0	9	9
403	R:R:D120	R:R:N92	13.46	Yes	No	0	9	9
404	R:R:N92	R:R:P377	8.15	No	Yes	0	9	9
405	R:R:I93	R:R:L94	2.85	No	No	0	3	6
406	R:R:I93	R:R:M97	2.92	No	No	0	3	4
407	R:R:I93	R:R:M121	4.37	No	No	0	3	7
408	R:R:F391	R:R:L94	14.61	Yes	No	0	6	6
409	R:R:V95	R:R:V99	1.6	Yes	Yes	0	9	7
410	R:R:A117	R:R:V95	3.39	No	Yes	0	9	9
411	R:R:P377	R:R:V95	3.53	Yes	Yes	0	9	9
412	R:R:V95	R:R:Y380	3.79	Yes	Yes	0	9	9
413	R:R:F391	R:R:V95	5.24	Yes	Yes	0	6	9
414	R:R:I96	R:R:M114	7.29	No	No	0	6	5
415	R:R:I118	R:R:I96	5.89	No	No	0	6	6
416	R:R:M97	R:R:Y394	5.99	No	Yes	0	4	4
417	R:R:A98	R:R:Y387	2.67	Yes	Yes	4	7	8
418	R:R:A390	R:R:A98	1.79	No	Yes	4	7	7
419	R:R:A98	R:R:F391	2.77	Yes	Yes	4	7	6
420	R:R:A98	R:R:Y394	2.67	Yes	Yes	4	7	4
421	R:R:N110	R:R:V99	2.96	Yes	Yes	4	9	7
422	R:R:V99	R:R:Y111	2.52	Yes	No	4	7	4
423	R:R:M114	R:R:V99	4.56	No	Yes	4	5	7
424	R:R:V99	R:R:Y387	5.05	Yes	Yes	4	7	8
425	R:R:L101	R:R:S100	4.5	No	No	0	5	1
426	R:R:L101	R:R:Y394	8.21	No	Yes	4	5	4
427	R:R:L101	R:R:Y399	14.07	No	No	4	5	2
428	R:R:A390	R:R:E102	1.51	No	No	0	7	6
429	R:R:E102	R:R:R393	10.47	No	No	0	6	4
430	R:R:L105	R:R:N110	5.49	Yes	Yes	4	8	9
431	R:R:L105	R:R:N384	4.12	Yes	No	4	8	9
432	R:R:L105	R:R:T386	7.37	Yes	No	4	8	6
433	R:R:L105	R:R:Y387	10.55	Yes	Yes	4	8	8
434	R:R:A108	R:R:N107	1.56	No	No	0	5	7
435	R:R:N107	R:R:T109	4.39	No	No	0	7	8
436	R:R:N107	R:R:N110	4.09	No	Yes	0	7	9
437	R:R:R173	R:R:T109	6.47	Yes	No	0	9	8
438	R:R:N110	R:R:Y387	10.47	Yes	Yes	4	9	8
439	R:R:M114	R:R:Y111	8.38	No	No	4	5	4
440	R:R:A192	R:R:Y111	4	No	No	0	7	4
441	R:R:A168	R:R:F112	4.16	No	Yes	0	7	8
442	R:R:F112	R:R:I169	10.05	Yes	No	0	8	9
443	R:R:D172	R:R:F112	2.39	No	Yes	12	9	8
444	R:R:F112	R:R:K195	7.44	Yes	No	12	8	6
445	R:R:L113	R:R:Y380	9.38	No	Yes	4	8	9
446	R:R:L113	R:R:Y387	2.34	No	Yes	4	8	8
447	R:R:H165	R:R:S115	11.16	Yes	No	0	8	9
448	R:R:I196	R:R:S115	4.64	No	No	0	8	9
449	R:R:D120	R:R:L116	4.07	Yes	Yes	3	9	9
450	R:R:L116	R:R:S162	3	Yes	Yes	3	9	9
451	R:R:H165	R:R:L116	9	Yes	Yes	3	8	9
452	R:R:L116	R:R:L166	2.77	Yes	Yes	3	9	8
453	R:R:A119	R:R:D120	1.54	No	Yes	3	8	9
454	R:R:A119	R:R:S162	1.71	No	Yes	3	8	9
455	R:R:A119	R:R:W200	2.59	No	Yes	3	8	9
456	R:R:D120	R:R:S162	2.94	Yes	Yes	3	9	9
457	R:R:D120	R:R:S373	7.36	Yes	Yes	3	9	9
458	R:R:D120	R:R:N376	4.04	Yes	Yes	0	9	9
459	R:R:F125	R:R:M121	4.98	No	No	0	4	7
460	R:R:F158	R:R:L122	14.61	Yes	No	0	7	7
461	R:R:G124	R:R:L123	1.71	No	Yes	3	6	7
462	R:R:L123	R:R:V127	4.47	Yes	Yes	3	7	8
463	R:R:L123	R:R:M128	2.83	Yes	Yes	3	7	8
464	R:R:F158	R:R:L123	7.31	Yes	Yes	3	7	7
465	R:R:L123	R:R:S159	3	Yes	No	3	7	7
466	R:R:L123	R:R:Y370	3.52	Yes	Yes	3	7	7
467	R:R:L123	R:R:S373	1.5	Yes	Yes	3	7	9
468	R:R:G124	R:R:M128	5.24	No	Yes	3	6	8
469	R:R:L126	R:R:V127	1.49	No	Yes	3	5	8
470	R:R:L126	R:R:L154	6.92	No	No	3	5	5
471	R:R:F158	R:R:L126	3.65	Yes	No	3	7	5
472	R:R:V127	R:R:W151	4.9	Yes	Yes	3	8	5
473	R:R:L154	R:R:V127	4.47	No	Yes	3	5	8
474	R:R:D155	R:R:V127	5.84	Yes	Yes	3	8	8
475	R:R:M128	R:R:P129	1.68	Yes	No	3	8	8
476	R:R:M128	R:R:W367	2.33	Yes	Yes	3	8	6
477	R:R:M128	R:R:Y370	7.18	Yes	Yes	3	8	7
478	R:R:M128	R:R:S373	1.53	Yes	Yes	3	8	9
479	R:R:V130	R:R:W141	2.45	No	Yes	3	4	7
480	R:R:L143	R:R:V130	2.98	Yes	No	3	5	4
481	R:R:V130	R:R:W151	9.81	No	Yes	3	4	5
482	R:R:S131	R:R:W151	2.47	No	Yes	3	7	5
483	R:R:S131	R:R:W367	6.18	No	Yes	3	7	6
484	R:R:S131	R:R:Y370	3.82	No	Yes	3	7	7
485	R:R:L133	R:R:P142	4.93	No	Yes	0	4	3
486	R:R:T134	R:R:Y139	2.5	No	Yes	0	5	3
487	R:R:T134	R:R:W141	2.43	No	Yes	3	5	7
488	R:R:P142	R:R:T134	6.99	Yes	No	3	3	5
489	R:R:I135	R:R:Y139	8.46	No	Yes	0	5	3
490	R:R:I135	R:R:W367	3.52	No	Yes	0	5	6
491	R:R:P142	R:R:Y137	11.13	Yes	No	0	3	4
492	R:R:G138	R:R:Y139	2.9	No	Yes	0	5	3
493	R:R:N363	R:R:Y139	18.61	No	Yes	0	4	3
494	R:R:G225	R:R:R140	3	No	No	0	3	4
495	R:R:P142	R:R:W141	5.4	Yes	Yes	3	3	7
496	R:R:L143	R:R:W141	4.56	Yes	Yes	3	5	7
497	R:R:L147	R:R:W141	4.56	Yes	Yes	3	5	7
498	R:R:C148	R:R:W141	13.06	Yes	Yes	3	9	7
499	R:R:W141	R:R:W151	10.31	Yes	Yes	3	7	5
500	R:R:F222	R:R:W141	6.01	No	Yes	3	2	7
501	R:R:C227	R:R:W141	5.22	Yes	Yes	3	9	7
502	R:R:L143	R:R:P142	4.93	Yes	Yes	3	5	3
503	R:R:L143	R:R:P144	3.28	Yes	No	3	5	7
504	R:R:L143	R:R:L147	6.92	Yes	Yes	3	5	5
505	R:R:L147	R:R:P144	4.93	Yes	No	3	5	7
506	R:R:K146	R:R:L215	2.82	No	No	0	1	5
507	R:R:L147	R:R:V150	1.49	Yes	No	0	5	4
508	R:R:C148	R:R:V221	3.42	Yes	Yes	3	9	3
509	R:R:C148	R:R:F222	2.79	Yes	No	3	9	2
510	R:R:C148	R:R:C227	7.28	Yes	Yes	3	9	9
511	R:R:A149	R:R:I210	1.62	No	Yes	0	6	6
512	R:R:A149	R:R:G214	1.95	No	No	0	6	7
513	R:R:I152	R:R:W151	2.35	Yes	Yes	3	5	5
514	R:R:C227	R:R:W151	2.61	Yes	Yes	3	9	5
515	R:R:I152	R:R:V156	1.54	Yes	Yes	3	5	6
516	R:R:I152	R:R:I210	4.42	Yes	Yes	3	5	6
517	R:R:I152	R:R:V221	3.07	Yes	Yes	3	5	3
518	R:R:C227	R:R:I152	1.64	Yes	Yes	3	9	5
519	R:R:I152	R:R:L229	8.56	Yes	Yes	3	5	4
520	R:R:V204	R:R:Y153	2.52	Yes	Yes	3	4	6
521	R:R:S207	R:R:Y153	6.36	Yes	Yes	0	7	6
522	R:R:M208	R:R:Y153	2.39	Yes	Yes	3	4	6
523	R:R:I210	R:R:Y153	2.42	Yes	Yes	3	6	6
524	R:R:P211	R:R:Y153	6.95	No	Yes	3	5	6
525	R:R:F158	R:R:L154	6.09	Yes	No	3	7	5
526	R:R:D155	R:R:S159	4.42	Yes	No	3	8	7
527	R:R:D155	R:R:Y370	12.64	Yes	Yes	3	8	7
528	R:R:S207	R:R:V156	3.23	Yes	Yes	0	7	6
529	R:R:I210	R:R:V156	4.61	Yes	Yes	3	6	6
530	R:R:F158	R:R:L157	6.09	Yes	Yes	0	7	6
531	R:R:L157	R:R:S203	4.5	Yes	No	0	6	8
532	R:R:L157	R:R:V204	2.98	Yes	Yes	0	6	4
533	R:R:L157	R:R:S207	4.5	Yes	Yes	0	6	7
534	R:R:F158	R:R:W200	2	Yes	Yes	3	7	9
535	R:R:M164	R:R:T160	1.51	No	Yes	0	6	7
536	R:R:S203	R:R:T160	3.2	No	Yes	0	8	7
537	R:R:I206	R:R:T160	1.52	No	Yes	3	6	7
538	R:R:S207	R:R:T160	1.6	Yes	Yes	0	7	7
539	R:R:S242	R:R:T160	4.8	Yes	Yes	3	6	7
540	R:R:A161	R:R:H165	2.93	No	Yes	3	8	8
541	R:R:A161	R:R:W200	7.78	No	Yes	3	8	9
542	R:R:A161	R:R:S203	3.42	No	No	0	8	8
543	R:R:F332	R:R:S162	2.64	Yes	Yes	3	9	9
544	R:R:I163	R:R:P246	5.08	No	No	0	8	9
545	R:R:F332	R:R:I163	6.28	Yes	No	0	9	8
546	R:R:M164	R:R:V199	1.52	No	No	0	6	6
547	R:R:M164	R:R:P246	6.71	No	No	0	6	9
548	R:R:H165	R:R:V199	11.07	Yes	No	0	8	6
549	R:R:H165	R:R:W200	10.58	Yes	Yes	3	8	9
550	R:R:L166	R:R:M250	4.24	Yes	Yes	3	8	8
551	R:R:L166	R:R:V328	1.49	Yes	No	0	8	8
552	R:R:F329	R:R:L166	4.87	Yes	Yes	3	8	8
553	R:R:F332	R:R:L166	6.09	Yes	Yes	3	9	8
554	R:R:C167	R:R:I249	3.27	No	No	0	6	6
555	R:R:C167	R:R:M250	1.62	No	Yes	0	6	8
556	R:R:A168	R:R:V199	1.7	No	No	0	7	6
557	R:R:I169	R:R:L325	2.85	No	No	0	9	8
558	R:R:F329	R:R:I169	2.51	Yes	No	0	8	9
559	R:R:S170	R:R:T253	6.4	No	No	0	9	5
560	R:R:F329	R:R:S170	6.61	Yes	No	0	8	9
561	R:R:D172	R:R:K195	8.3	No	No	12	9	6
562	R:R:E318	R:R:R173	4.65	No	Yes	11	8	9
563	R:R:A321	R:R:R173	4.15	No	Yes	11	8	9
564	R:R:L325	R:R:R173	4.86	No	Yes	0	8	9
565	R:R:V175	R:R:Y174	2.52	No	Yes	0	5	8
566	R:R:Q178	R:R:Y174	2.25	No	Yes	0	6	8
567	R:R:T253	R:R:Y174	4.99	No	Yes	0	5	8
568	R:R:L256	R:R:Y174	4.69	No	Yes	0	5	8
569	R:R:T257	R:R:Y174	3.75	No	Yes	0	9	8
570	R:R:I177	R:R:T257	7.6	No	No	13	9	9
571	R:R:I177	R:R:S260	7.74	No	No	0	9	6
572	R:R:I177	R:R:L261	8.56	No	No	13	9	8
573	R:R:Q178	R:R:S260	4.33	No	No	0	6	6
574	R:R:N179	R:R:P180	3.26	No	No	14	6	8
575	R:R:H182	R:R:N179	12.75	No	No	14	5	6
576	R:R:I181	R:R:P180	1.69	No	No	0	7	8
577	R:R:H182	R:R:P180	15.25	No	No	14	5	8
578	R:R:F186	R:R:S184	7.93	No	No	0	4	6
579	R:R:F186	R:R:N187	8.46	No	No	0	4	6
580	R:R:N187	R:R:T190	7.31	No	Yes	15	6	5
581	R:R:L194	R:R:N187	5.49	No	No	15	3	6
582	R:R:S188	R:R:T190	1.6	No	Yes	0	7	5
583	R:R:L194	R:R:T190	2.95	No	Yes	15	3	5
584	R:R:K191	R:R:K195	17.24	No	No	0	6	6
585	R:R:F193	R:R:I197	5.02	No	No	0	4	2
586	R:R:I202	R:R:T201	1.52	No	No	0	5	4
587	R:R:G205	R:R:V204	1.84	No	Yes	0	4	4
588	R:R:M208	R:R:V204	1.52	Yes	Yes	3	4	4
589	R:R:I206	R:R:V241	4.61	No	No	3	6	4
590	R:R:I206	R:R:S242	3.1	No	Yes	3	6	6
591	R:R:M208	R:R:P209	1.68	Yes	No	0	4	7
592	R:R:M208	R:R:P211	1.68	Yes	No	3	4	5
593	R:R:I210	R:R:P211	3.39	Yes	No	3	6	5
594	R:R:F213	R:R:V212	7.87	No	No	0	4	5
595	R:R:F213	R:R:F234	5.36	No	No	0	4	7
596	R:R:G214	R:R:L215	1.71	No	No	0	7	5
597	R:R:D231	R:R:K220	4.15	No	No	0	5	3
598	R:R:C227	R:R:V221	1.71	Yes	Yes	3	9	3
599	R:R:L229	R:R:V221	1.49	Yes	Yes	3	4	3
600	R:R:K223	R:R:L228	11.28	No	No	16	3	4
601	R:R:A230	R:R:K223	6.42	No	No	16	3	3
602	R:R:A230	R:R:L228	1.58	No	No	16	3	4
603	R:R:F234	R:R:L229	4.87	No	Yes	0	7	4
604	R:R:L229	R:R:V235	2.98	Yes	Yes	3	4	6
605	R:R:D231	R:R:F234	16.72	No	No	0	5	7
606	R:R:D232	R:R:V347	7.3	No	Yes	0	4	5
607	R:R:D232	R:R:K350	5.53	No	No	0	4	1
608	R:R:N343	R:R:V235	2.96	Yes	Yes	3	7	6
609	R:R:V235	R:R:V347	1.6	Yes	Yes	0	6	5
610	R:R:I344	R:R:L236	2.85	No	No	0	5	6
611	R:R:L236	R:R:V347	2.98	No	Yes	0	6	5
612	R:R:G238	R:R:I237	3.53	No	No	0	6	4
613	R:R:I237	R:R:V241	1.54	No	No	0	4	4
614	R:R:F244	R:R:S239	3.96	Yes	No	3	5	6
615	R:R:F340	R:R:S239	3.96	Yes	No	3	7	6
616	R:R:I344	R:R:S239	7.74	No	No	0	5	6
617	R:R:F240	R:R:F244	9.65	No	Yes	0	4	5
618	R:R:F240	R:R:I245	2.51	No	No	0	4	5
619	R:R:F240	R:R:I344	3.77	No	No	0	4	5
620	R:R:S242	R:R:V241	1.62	Yes	No	3	6	4
621	R:R:F243	R:R:F244	7.5	Yes	Yes	3	8	5
622	R:R:F243	R:R:W336	4.01	Yes	Yes	3	8	8
623	R:R:C337	R:R:F243	2.79	No	Yes	0	6	8
624	R:R:F243	R:R:F340	22.51	Yes	Yes	3	8	7
625	R:R:F244	R:R:F340	2.14	Yes	Yes	3	5	7
626	R:R:I245	R:R:P246	3.39	No	No	0	5	9
627	R:R:A247	R:R:V333	3.39	No	No	0	6	6
628	R:R:I252	R:R:T248	1.52	No	No	0	5	3
629	R:R:F329	R:R:M250	12.44	Yes	Yes	3	8	8
630	R:R:M250	R:R:V333	1.52	Yes	No	0	8	6
631	R:R:F255	R:R:V251	2.62	No	No	0	1	5
632	R:R:F255	R:R:Y254	6.19	No	Yes	0	1	9
633	R:R:I258	R:R:Y254	14.51	No	Yes	0	5	9
634	R:R:G326	R:R:Y254	5.79	No	Yes	3	6	9
635	R:R:F329	R:R:Y254	9.28	Yes	Yes	3	8	9
636	R:R:L261	R:R:T257	2.95	No	No	13	8	9
637	R:R:I258	R:R:Q262	4.12	No	No	0	5	6
638	R:R:C322	R:R:I258	6.55	No	No	0	7	5
639	R:R:K259	R:R:Q262	20.34	No	No	0	4	6
640	R:R:C322	R:R:L261	1.59	No	No	0	7	8
641	R:R:A265	R:R:I315	3.25	No	No	0	5	5
642	R:R:M312	R:R:T311	3.01	No	No	0	4	4
643	R:R:K320	R:R:S316	6.12	No	No	0	8	6
644	R:R:A321	R:R:E318	1.51	No	No	11	8	8
645	R:R:K320	R:R:Q319	2.71	No	No	0	8	5
646	R:R:I327	R:R:K323	2.91	Yes	No	8	6	7
647	R:R:F383	R:R:K323	3.72	Yes	No	8	7	7
648	R:R:F383	R:R:V324	3.93	Yes	No	0	7	8
649	R:R:G326	R:R:L325	1.71	No	No	0	6	8
650	R:R:F329	R:R:G326	1.51	Yes	No	3	8	6
651	R:R:I327	R:R:L331	2.85	Yes	No	0	6	6
652	R:R:I327	R:R:V379	7.68	Yes	Yes	8	6	8
653	R:R:F383	R:R:I327	3.77	Yes	Yes	8	7	6
654	R:R:N376	R:R:V328	7.39	Yes	No	0	9	8
655	R:R:V328	R:R:V379	1.6	No	Yes	0	8	8
656	R:R:F330	R:R:V334	13.11	No	No	0	5	5
657	R:R:L331	R:R:V375	5.96	No	No	0	6	6
658	R:R:F332	R:R:W336	7.02	Yes	Yes	3	9	8
659	R:R:F332	R:R:S372	3.96	Yes	Yes	3	9	9
660	R:R:I368	R:R:M335	2.92	No	Yes	0	7	8
661	R:R:A371	R:R:M335	1.61	No	Yes	0	4	8
662	R:R:M335	R:R:S372	1.53	Yes	Yes	0	8	9
663	R:R:M335	R:R:V375	1.52	Yes	No	0	8	6
664	R:R:F339	R:R:W336	8.02	Yes	Yes	3	7	8
665	R:R:F340	R:R:W336	6.01	Yes	Yes	3	7	8
666	R:R:V366	R:R:W336	2.45	Yes	Yes	3	6	8
667	R:R:G369	R:R:W336	12.67	No	Yes	3	7	8
668	R:R:W336	R:R:Y370	3.86	Yes	Yes	3	8	7
669	R:R:S372	R:R:W336	2.47	Yes	Yes	3	9	8
670	R:R:C337	R:R:P338	1.88	No	No	0	6	9
671	R:R:F365	R:R:P338	7.22	Yes	No	0	5	9
672	R:R:F339	R:R:F340	6.43	Yes	Yes	3	7	7
673	R:R:F339	R:R:N343	4.83	Yes	Yes	3	7	7
674	R:R:F339	R:R:L362	2.44	Yes	Yes	3	7	3
675	R:R:F339	R:R:V366	3.93	Yes	Yes	3	7	6
676	R:R:L361	R:R:T342	2.95	No	No	3	4	5
677	R:R:L362	R:R:T342	5.9	Yes	No	3	3	5
678	R:R:F365	R:R:T342	6.49	Yes	No	3	5	5
679	R:R:L362	R:R:N343	4.12	Yes	Yes	3	3	7
680	R:R:I348	R:R:M345	2.92	No	No	17	4	4
681	R:R:C349	R:R:M345	1.62	Yes	No	17	3	4
682	R:R:A346	R:R:V347	1.7	No	Yes	0	4	5
683	R:R:A346	R:R:E355	3.02	No	No	18	4	3
684	R:R:A346	R:R:I358	1.62	No	Yes	18	4	4
685	R:R:C349	R:R:I348	1.64	Yes	No	17	3	4
686	R:R:C349	R:R:S352	3.44	Yes	No	0	3	2
687	R:R:C349	R:R:C353	5.46	Yes	No	0	3	3
688	R:R:E351	R:R:K350	2.7	No	No	0	5	1
689	R:R:D356	R:R:N354	8.08	No	No	0	2	1
690	R:R:N354	R:R:V357	4.43	No	No	0	1	5
691	R:R:E355	R:R:I358	8.2	No	Yes	18	3	4
692	R:R:I358	R:R:V357	1.54	Yes	No	0	4	5
693	R:R:G359	R:R:I358	1.76	No	Yes	0	2	4
694	R:R:G359	R:R:L362	3.42	No	Yes	0	2	3
695	R:R:F365	R:R:L361	8.53	Yes	No	3	5	4
696	R:R:F365	R:R:V364	3.93	Yes	No	0	5	4
697	R:R:F365	R:R:I368	3.77	Yes	No	0	5	7
698	R:R:V366	R:R:W367	2.45	Yes	Yes	3	6	6
699	R:R:V366	R:R:Y370	5.05	Yes	Yes	3	6	7
700	R:R:W367	R:R:Y370	5.79	Yes	Yes	3	6	7
701	R:R:G369	R:R:I368	1.76	No	No	0	7	7
702	R:R:G369	R:R:S372	1.86	No	Yes	3	7	9
703	R:R:V375	R:R:V379	1.6	No	Yes	0	6	8
704	R:R:N376	R:R:P377	6.52	Yes	Yes	0	9	9
705	R:R:N376	R:R:Y380	8.14	Yes	Yes	0	9	9
706	R:R:F383	R:R:V379	5.24	Yes	Yes	8	7	8
707	R:R:Y380	R:R:Y387	8.94	Yes	Yes	4	9	8
708	R:R:L382	R:R:T381	2.95	No	No	0	5	7
709	R:R:F391	R:R:T381	3.89	Yes	No	0	6	7
710	R:R:F383	R:R:L382	7.31	Yes	No	0	7	5
711	R:R:N384	R:R:T386	13.16	No	No	4	9	6
712	R:R:N384	R:R:Y387	12.79	No	Yes	4	9	8
713	R:R:K385	R:R:R388	3.71	No	No	0	5	9
714	R:R:F391	R:R:Y387	5.16	Yes	Yes	4	6	8
715	R:R:R393	R:R:S389	9.22	No	No	0	4	4
716	R:R:A390	R:R:Y394	4	No	Yes	4	7	4
717	R:R:S392	S:S:T190	3.2	No	No	0	3	5
718	R:R:Y394	R:R:Y399	3.97	Yes	No	4	4	2
719	R:R:Q396	S:S:R189	14.02	No	No	0	4	4
720	S:S:K74	S:S:L71	5.64	Yes	Yes	6	6	3
721	S:S:K74	S:S:N75	4.2	Yes	Yes	6	6	5
722	S:S:K74	S:S:S77	1.53	Yes	No	0	6	3
723	S:S:N75	S:S:W76	7.91	Yes	No	0	5	4
724	S:S:L79	S:S:W76	3.42	Yes	No	0	4	4
725	S:S:A78	S:S:S77	1.71	No	No	0	6	3
726	S:S:I135	S:S:S77	1.55	Yes	No	0	5	3
727	S:S:A78	S:S:L136	1.58	No	No	0	6	5
728	S:S:L79	S:S:V83	2.98	Yes	No	0	4	4
729	S:S:M132	S:S:T81	6.02	No	No	0	6	6
730	S:S:I135	S:S:T81	1.52	Yes	No	1	5	6
731	S:S:T81	S:S:W367	18.19	No	Yes	1	6	6
732	S:S:A82	S:S:M132	1.61	No	No	0	3	6
733	S:S:L87	S:S:V83	2.98	No	No	0	4	4
734	S:S:T88	S:S:V84	1.59	Yes	Yes	1	7	7
735	S:S:M128	S:S:V84	1.52	Yes	Yes	1	8	7
736	S:S:V84	S:S:W367	4.9	Yes	Yes	1	7	6
737	S:S:A371	S:S:V84	3.39	No	Yes	0	4	7
738	S:S:I85	S:S:I89	2.94	Yes	No	0	6	5
739	S:S:I85	S:S:M128	4.37	Yes	Yes	1	6	8
740	S:S:I85	S:S:P129	6.77	Yes	No	1	6	8
741	S:S:I85	S:S:W367	3.52	Yes	Yes	1	6	6
742	S:S:A374	S:S:L87	3.15	No	No	0	6	4
743	S:S:I89	S:S:T88	1.52	No	Yes	0	5	7
744	S:S:G124	S:S:T88	1.82	No	Yes	1	6	7
745	S:S:M128	S:S:T88	4.52	Yes	Yes	1	8	7
746	S:S:S373	S:S:T88	3.2	Yes	Yes	1	9	7
747	S:S:A374	S:S:T88	1.68	No	Yes	0	6	7
748	S:S:G91	S:S:P377	4.06	No	Yes	0	8	9
749	S:S:A117	S:S:N92	4.69	No	No	0	9	9
750	S:S:D120	S:S:N92	6.73	Yes	No	0	9	9
751	S:S:N92	S:S:P377	8.15	No	Yes	0	9	9
752	S:S:I93	S:S:M97	4.37	No	No	0	3	4
753	S:S:I93	S:S:M121	2.92	No	No	0	3	7
754	S:S:F391	S:S:L94	15.83	Yes	No	0	6	6
755	S:S:A117	S:S:V95	3.39	No	Yes	0	9	9
756	S:S:P377	S:S:V95	3.53	Yes	Yes	0	9	9
757	S:S:V95	S:S:Y380	8.83	Yes	Yes	0	9	9
758	S:S:F391	S:S:V95	2.62	Yes	Yes	0	6	9
759	S:S:A117	S:S:I96	1.62	No	No	0	9	6
760	S:S:I118	S:S:I96	5.89	No	No	0	6	6
761	S:S:M97	S:S:Y394	7.18	No	Yes	0	4	4
762	S:S:A98	S:S:Y387	2.67	No	Yes	5	7	8
763	S:S:A390	S:S:A98	1.79	No	No	0	7	7
764	S:S:A98	S:S:F391	2.77	No	Yes	5	7	6
765	S:S:L105	S:S:V99	1.49	Yes	Yes	5	8	7
766	S:S:V99	S:S:Y111	2.52	Yes	Yes	5	7	4
767	S:S:M114	S:S:V99	9.13	No	Yes	5	5	7
768	S:S:V99	S:S:Y387	3.79	Yes	Yes	5	7	8
769	S:S:L101	S:S:S100	1.5	No	No	0	5	1
770	S:S:M114	S:S:S100	1.53	No	No	0	5	1
771	S:S:L101	S:S:Y394	8.21	No	Yes	5	5	4
772	S:S:L101	S:S:Y399	24.62	No	No	5	5	2
773	S:S:E102	S:S:K104	12.15	Yes	No	5	6	6
774	S:S:E102	S:S:L105	3.98	Yes	Yes	5	6	8
775	S:S:E102	S:S:T386	4.23	Yes	No	5	6	6
776	S:S:E102	S:S:R393	4.65	Yes	Yes	5	6	4
777	S:S:K104	S:S:T386	4.5	No	No	5	6	6
778	S:S:L105	S:S:N110	6.87	Yes	No	5	8	9
779	S:S:L105	S:S:T386	7.37	Yes	No	5	8	6
780	S:S:L105	S:S:Y387	7.03	Yes	Yes	5	8	8
781	S:S:Q106	S:S:Y111	11.27	No	Yes	0	7	4
782	S:S:N107	S:S:T109	2.92	No	No	0	7	8
783	S:S:N107	S:S:N110	10.9	No	No	0	7	9
784	S:S:A108	S:S:A192	1.79	No	No	1	5	7
785	S:S:D172	S:S:T109	2.89	No	No	19	9	8
786	S:S:R173	S:S:T109	2.59	Yes	No	19	9	8
787	S:S:N110	S:S:Y387	5.81	No	Yes	5	9	8
788	S:S:M114	S:S:Y111	2.39	No	Yes	5	5	4
789	S:S:R189	S:S:Y111	3.09	No	Yes	0	4	4
790	S:S:F112	S:S:I169	8.79	Yes	No	0	8	9
791	S:S:F112	S:S:K195	3.72	Yes	No	0	8	6
792	S:S:F112	S:S:I196	7.54	Yes	Yes	1	8	8
793	S:S:I169	S:S:L113	2.85	No	No	0	9	8
794	S:S:L113	S:S:Y380	7.03	No	Yes	0	8	9
795	S:S:I118	S:S:S115	3.1	No	Yes	0	6	9
796	S:S:H165	S:S:S115	6.97	Yes	Yes	1	8	9
797	S:S:I196	S:S:S115	1.55	Yes	Yes	1	8	9
798	S:S:S115	S:S:W200	4.94	Yes	Yes	1	9	9
799	S:S:D120	S:S:L116	2.71	Yes	Yes	1	9	9
800	S:S:L116	S:S:S162	3	Yes	Yes	1	9	9
801	S:S:H165	S:S:L116	9	Yes	Yes	1	8	9
802	S:S:L116	S:S:L166	2.77	Yes	Yes	1	9	8
803	S:S:A119	S:S:S162	1.71	No	Yes	0	8	9
804	S:S:A119	S:S:W200	2.59	No	Yes	0	8	9
805	S:S:D120	S:S:S162	4.42	Yes	Yes	1	9	9
806	S:S:D120	S:S:S373	10.31	Yes	Yes	1	9	9
807	S:S:F158	S:S:L122	7.31	Yes	No	0	7	7
808	S:S:G124	S:S:L123	1.71	No	Yes	0	6	7
809	S:S:L123	S:S:V127	2.98	Yes	Yes	0	7	8
810	S:S:F158	S:S:L123	3.65	Yes	Yes	0	7	7
811	S:S:L123	S:S:S159	3	Yes	No	0	7	7
812	S:S:L123	S:S:S373	1.5	Yes	Yes	0	7	9
813	S:S:G124	S:S:M128	5.24	No	Yes	1	6	8
814	S:S:F125	S:S:L126	6.09	No	No	0	4	5
815	S:S:L126	S:S:V127	1.49	No	Yes	0	5	8
816	S:S:V127	S:S:W151	2.45	Yes	Yes	1	8	5
817	S:S:L154	S:S:V127	2.98	No	Yes	0	5	8
818	S:S:D155	S:S:V127	10.22	Yes	Yes	1	8	8
819	S:S:V127	S:S:Y370	2.52	Yes	Yes	1	8	7
820	S:S:M128	S:S:P129	1.68	Yes	No	1	8	8
821	S:S:M128	S:S:W367	3.49	Yes	Yes	1	8	6
822	S:S:M128	S:S:Y370	9.58	Yes	Yes	1	8	7
823	S:S:M128	S:S:S373	3.07	Yes	Yes	1	8	9
824	S:S:T134	S:S:V130	1.59	No	Yes	1	5	4
825	S:S:V130	S:S:W141	3.68	Yes	Yes	1	4	7
826	S:S:L143	S:S:V130	1.49	Yes	Yes	1	5	4
827	S:S:V130	S:S:W151	12.26	Yes	Yes	1	4	5
828	S:S:S131	S:S:W367	7.41	No	Yes	1	7	6
829	S:S:S131	S:S:Y370	2.54	No	Yes	1	7	7
830	S:S:L136	S:S:M132	2.83	No	No	0	5	6
831	S:S:L133	S:S:L136	2.77	No	No	0	4	5
832	S:S:L133	S:S:Y137	3.52	No	No	1	4	4
833	S:S:L133	S:S:P142	4.93	No	Yes	1	4	3
834	S:S:T134	S:S:W141	3.64	No	Yes	1	5	7
835	S:S:P142	S:S:T134	3.5	Yes	No	1	3	5
836	S:S:I135	S:S:Y139	9.67	Yes	No	0	5	3
837	S:S:I135	S:S:W367	2.35	Yes	Yes	1	5	6
838	S:S:P142	S:S:Y137	6.95	Yes	No	1	3	4
839	S:S:G138	S:S:Y139	2.9	No	No	0	5	3
840	S:S:N363	S:S:Y139	16.28	No	No	0	4	3
841	S:S:P142	S:S:W141	8.11	Yes	Yes	1	3	7
842	S:S:L143	S:S:W141	6.83	Yes	Yes	1	5	7
843	S:S:C148	S:S:W141	16.98	Yes	Yes	1	9	7
844	S:S:W141	S:S:W151	6.56	Yes	Yes	1	7	5
845	S:S:F222	S:S:W141	3.01	Yes	Yes	1	2	7
846	S:S:C227	S:S:W141	3.92	Yes	Yes	1	9	7
847	S:S:L143	S:S:P142	1.64	Yes	Yes	1	5	3
848	S:S:L143	S:S:P144	4.93	Yes	No	0	5	7
849	S:S:L147	S:S:P144	11.49	No	No	0	5	7
850	S:S:C148	S:S:W151	2.61	Yes	Yes	1	9	5
851	S:S:C148	S:S:I152	1.64	Yes	Yes	1	9	5
852	S:S:C148	S:S:F222	2.79	Yes	Yes	1	9	2
853	S:S:C148	S:S:C227	7.28	Yes	Yes	1	9	9
854	S:S:A149	S:S:G214	1.95	No	No	0	6	7
855	S:S:I152	S:S:W151	3.52	Yes	Yes	1	5	5
856	S:S:I152	S:S:V156	1.54	Yes	Yes	1	5	6
857	S:S:I152	S:S:I210	5.89	Yes	Yes	1	5	6
858	S:S:I152	S:S:V221	3.07	Yes	Yes	1	5	3
859	S:S:C227	S:S:I152	3.27	Yes	Yes	1	9	5
860	S:S:I152	S:S:L229	5.71	Yes	Yes	1	5	4
861	S:S:L154	S:S:Y153	8.21	No	Yes	0	5	6
862	S:S:S207	S:S:Y153	10.17	No	Yes	1	7	6
863	S:S:I210	S:S:Y153	6.04	Yes	Yes	1	6	6
864	S:S:P211	S:S:Y153	8.34	No	Yes	1	5	6
865	S:S:D155	S:S:S159	2.94	Yes	No	1	8	7
866	S:S:D155	S:S:Y370	9.2	Yes	Yes	1	8	7
867	S:S:T160	S:S:V156	1.59	No	Yes	1	7	6
868	S:S:L229	S:S:V156	1.49	Yes	Yes	1	4	6
869	S:S:F158	S:S:L157	8.53	Yes	Yes	0	7	6
870	S:S:L157	S:S:S203	1.5	Yes	No	0	6	8
871	S:S:L157	S:S:V204	2.98	Yes	No	0	6	4
872	S:S:L157	S:S:S207	7.51	Yes	No	0	6	7
873	S:S:F158	S:S:W200	2	Yes	Yes	0	7	9
874	S:S:S242	S:S:T160	7.99	No	No	1	6	7
875	S:S:A161	S:S:W200	2.59	No	Yes	0	8	9
876	S:S:A161	S:S:S203	3.42	No	No	0	8	8
877	S:S:F332	S:S:S162	2.64	Yes	Yes	1	9	9
878	S:S:F243	S:S:I163	2.51	Yes	Yes	0	8	8
879	S:S:I163	S:S:P246	3.39	Yes	No	0	8	9
880	S:S:A247	S:S:I163	1.62	No	Yes	0	6	8
881	S:S:F332	S:S:I163	5.02	Yes	Yes	0	9	8
882	S:S:M164	S:S:V199	9.13	No	No	0	6	6
883	S:S:I202	S:S:M164	5.83	No	No	0	5	6
884	S:S:M164	S:S:S203	3.07	No	No	0	6	8
885	S:S:H165	S:S:V199	4.15	Yes	No	0	8	6
886	S:S:H165	S:S:W200	8.46	Yes	Yes	1	8	9
887	S:S:L166	S:S:M250	4.24	Yes	Yes	1	8	8
888	S:S:L166	S:S:V328	1.49	Yes	Yes	1	8	8
889	S:S:F329	S:S:L166	3.65	Yes	Yes	1	8	8
890	S:S:F332	S:S:L166	6.09	Yes	Yes	1	9	8
891	S:S:C167	S:S:I249	3.27	No	No	0	6	6
892	S:S:C167	S:S:M250	4.86	No	Yes	0	6	8
893	S:S:A168	S:S:V199	5.09	No	No	0	7	6
894	S:S:S170	S:S:T253	4.8	No	No	0	9	5
895	S:S:F329	S:S:S170	5.28	Yes	No	0	8	9
896	S:S:D172	S:S:R173	3.57	No	Yes	19	9	9
897	S:S:C322	S:S:R173	4.18	No	Yes	0	7	9
898	S:S:L325	S:S:R173	3.64	No	Yes	0	8	9
899	S:S:L256	S:S:Y174	3.52	No	No	0	5	8
900	S:S:T257	S:S:Y174	7.49	No	No	0	9	8
901	S:S:I177	S:S:S260	4.64	No	No	0	9	6
902	S:S:R189	S:S:T190	3.88	No	No	0	4	5
903	S:S:K191	S:S:L194	4.23	No	No	0	6	3
904	S:S:F193	S:S:I197	5.02	No	No	0	4	2
905	S:S:K195	S:S:L194	2.82	No	No	0	6	3
906	S:S:I196	S:S:W200	2.35	Yes	Yes	1	8	9
907	S:S:I202	S:S:T201	1.52	No	No	0	5	4
908	S:S:I206	S:S:V241	3.07	No	No	0	6	4
909	S:S:I210	S:S:S207	1.55	Yes	No	1	6	7
910	S:S:M208	S:S:P209	1.68	No	No	0	4	7
911	S:S:F234	S:S:P209	4.33	Yes	No	0	7	7
912	S:S:I210	S:S:P211	6.77	Yes	No	1	6	5
913	S:S:I210	S:S:L229	2.85	Yes	Yes	1	6	4
914	S:S:F213	S:S:G214	1.51	Yes	No	0	4	7
915	S:S:F213	S:S:Q216	2.34	Yes	No	0	4	6
916	S:S:F213	S:S:K220	3.72	Yes	No	0	4	3
917	S:S:D231	S:S:F213	13.14	No	Yes	1	5	4
918	S:S:F213	S:S:F234	18.22	Yes	Yes	1	4	7
919	S:S:G214	S:S:V221	1.84	No	Yes	0	7	3
920	S:S:A230	S:S:K220	1.61	No	No	0	3	3
921	S:S:F222	S:S:V221	2.62	Yes	Yes	1	2	3
922	S:S:C227	S:S:V221	3.42	Yes	Yes	1	9	3
923	S:S:C227	S:S:F222	8.38	Yes	Yes	1	9	2
924	S:S:K223	S:S:L228	8.46	No	No	1	3	4
925	S:S:A230	S:S:K223	1.61	No	No	1	3	3
926	S:S:E355	S:S:K223	2.7	Yes	No	1	3	3
927	S:S:L228	S:S:S226	1.5	No	No	0	4	4
928	S:S:A230	S:S:L228	1.58	No	No	1	3	4
929	S:S:F234	S:S:L229	3.65	Yes	Yes	1	7	4
930	S:S:L229	S:S:V235	1.49	Yes	Yes	1	4	6
931	S:S:D231	S:S:N233	2.69	No	No	0	5	3
932	S:S:D231	S:S:F234	9.55	No	Yes	1	5	7
933	S:S:D232	S:S:V347	10.22	No	No	0	4	5
934	S:S:D232	S:S:K350	4.15	No	No	0	4	1
935	S:S:S239	S:S:V235	1.62	Yes	Yes	1	6	6
936	S:S:V235	S:S:V347	3.21	Yes	No	0	6	5
937	S:S:I344	S:S:L236	2.85	No	No	0	5	6
938	S:S:L236	S:S:V347	4.47	No	No	0	6	5
939	S:S:G238	S:S:I237	1.76	No	No	0	6	4
940	S:S:I237	S:S:V241	1.54	No	No	0	4	4
941	S:S:F340	S:S:S239	5.28	Yes	Yes	1	7	6
942	S:S:N343	S:S:S239	1.49	Yes	Yes	1	7	6
943	S:S:I344	S:S:S239	4.64	No	Yes	0	5	6
944	S:S:F240	S:S:F244	11.79	No	No	0	4	5
945	S:S:F243	S:S:F244	9.65	Yes	No	1	8	5
946	S:S:F243	S:S:V333	2.62	Yes	Yes	0	8	6
947	S:S:F243	S:S:W336	2	Yes	Yes	1	8	8
948	S:S:F243	S:S:F340	21.43	Yes	Yes	1	8	7
949	S:S:F244	S:S:F340	3.22	No	Yes	1	5	7
950	S:S:I245	S:S:P246	5.08	No	No	0	5	9
951	S:S:A247	S:S:V333	3.39	No	Yes	0	6	6
952	S:S:I252	S:S:T248	1.52	No	No	0	5	3
953	S:S:F329	S:S:M250	13.68	Yes	Yes	1	8	8
954	S:S:M250	S:S:V333	1.52	Yes	Yes	0	8	6
955	S:S:I252	S:S:L256	2.85	No	No	0	5	5
956	S:S:F255	S:S:Y254	5.16	No	Yes	0	1	9
957	S:S:I258	S:S:Y254	10.88	Yes	Yes	0	5	9
958	S:S:G326	S:S:Y254	7.24	No	Yes	0	6	9
959	S:S:F329	S:S:Y254	6.19	Yes	Yes	0	8	9
960	S:S:I258	S:S:T257	1.52	Yes	No	0	5	9
961	S:S:I258	S:S:Q262	4.12	Yes	No	0	5	6
962	S:S:C322	S:S:I258	4.91	No	Yes	0	7	5
963	S:S:A265	S:S:L261	1.58	No	No	0	5	8
964	S:S:E318	S:S:L261	5.3	No	No	0	8	8
965	S:S:E264	S:S:K263	4.05	No	No	0	7	5
966	S:S:M312	S:S:T311	1.51	No	No	0	4	4
967	S:S:N317	S:S:Q313	3.96	No	No	0	6	5
968	S:S:I315	S:S:S314	1.55	No	No	20	5	5
969	S:S:E318	S:S:S314	2.87	No	No	20	8	5
970	S:S:E318	S:S:I315	2.73	No	No	20	8	5
971	S:S:K323	S:S:Q319	2.71	No	No	0	7	5
972	S:S:K320	S:S:N384	2.8	No	No	0	8	9
973	S:S:F383	S:S:V324	2.62	No	No	0	7	8
974	S:S:I327	S:S:V379	7.68	No	No	0	6	8
975	S:S:F383	S:S:I327	3.77	No	No	0	7	6
976	S:S:F329	S:S:V328	3.93	Yes	Yes	1	8	8
977	S:S:N376	S:S:V328	5.91	No	Yes	0	9	8
978	S:S:V328	S:S:V379	1.6	Yes	No	0	8	8
979	S:S:F330	S:S:V334	11.8	No	No	0	5	5
980	S:S:L331	S:S:V375	5.96	No	No	0	6	6
981	S:S:F332	S:S:W336	9.02	Yes	Yes	1	9	8
982	S:S:F332	S:S:S372	5.28	Yes	Yes	1	9	9
983	S:S:V333	S:S:V334	1.6	Yes	No	0	6	5
984	S:S:G369	S:S:M335	1.75	No	Yes	0	7	8
985	S:S:A371	S:S:M335	1.61	No	Yes	0	4	8
986	S:S:M335	S:S:S372	3.07	Yes	Yes	0	8	9
987	S:S:M335	S:S:V375	1.52	Yes	No	0	8	6
988	S:S:F339	S:S:W336	7.02	Yes	Yes	1	7	8
989	S:S:F340	S:S:W336	3.01	Yes	Yes	1	7	8
990	S:S:G369	S:S:W336	12.67	No	Yes	0	7	8
991	S:S:S372	S:S:W336	3.71	Yes	Yes	1	9	8
992	S:S:C337	S:S:P338	1.88	No	No	0	6	9
993	S:S:C337	S:S:I341	3.27	No	No	0	6	6
994	S:S:F365	S:S:P338	8.67	Yes	No	0	5	9
995	S:S:F339	S:S:F340	9.65	Yes	Yes	1	7	7
996	S:S:F339	S:S:N343	7.25	Yes	Yes	1	7	7
997	S:S:F339	S:S:L362	4.87	Yes	No	1	7	3
998	S:S:F339	S:S:V366	6.55	Yes	No	1	7	6
999	S:S:I341	S:S:T342	1.52	No	No	0	6	5
1000	S:S:L362	S:S:T342	4.42	No	No	0	3	5
1001	S:S:F365	S:S:T342	5.19	Yes	No	0	5	5
1002	S:S:A346	S:S:N343	1.56	No	Yes	1	4	7
1003	S:S:L362	S:S:N343	5.49	No	Yes	1	3	7
1004	S:S:I348	S:S:M345	8.75	No	No	1	4	4
1005	S:S:C349	S:S:M345	1.62	No	No	1	3	4
1006	S:S:A346	S:S:E355	1.51	No	Yes	1	4	3
1007	S:S:A346	S:S:I358	3.25	No	Yes	1	4	4
1008	S:S:C349	S:S:I348	3.27	No	No	1	3	4
1009	S:S:C349	S:S:C353	7.28	No	No	1	3	3
1010	S:S:E351	S:S:K350	13.5	No	No	0	5	1
1011	S:S:C353	S:S:E355	1.52	No	Yes	1	3	3
1012	S:S:C353	S:S:I358	1.64	No	Yes	1	3	4
1013	S:S:N354	S:S:V357	8.87	No	No	0	1	5
1014	S:S:E355	S:S:I358	4.1	Yes	Yes	1	3	4
1015	S:S:I358	S:S:V357	3.07	Yes	No	0	4	5
1016	S:S:L361	S:S:V357	2.98	No	No	0	4	5
1017	S:S:G359	S:S:I358	1.76	No	Yes	0	2	4
1018	S:S:A360	S:S:N363	1.56	No	No	0	1	4
1019	S:S:F365	S:S:L361	6.09	Yes	No	0	5	4
1020	S:S:F365	S:S:I368	3.77	Yes	No	0	5	7
1021	S:S:V366	S:S:W367	3.68	No	Yes	1	6	6
1022	S:S:V366	S:S:Y370	6.31	No	Yes	1	6	7
1023	S:S:W367	S:S:Y370	10.61	Yes	Yes	1	6	7
1024	S:S:G369	S:S:I368	1.76	No	No	0	7	7
1025	S:S:S372	S:S:S373	1.63	Yes	Yes	1	9	9
1026	S:S:V375	S:S:V379	1.6	No	No	0	6	8
1027	S:S:N376	S:S:P377	1.63	No	Yes	0	9	9
1028	S:S:N376	S:S:Y380	3.49	No	Yes	0	9	9
1029	S:S:L378	S:S:P377	1.64	No	Yes	0	6	9
1030	S:S:Y380	S:S:Y387	17.87	Yes	Yes	0	9	8
1031	S:S:F391	S:S:T381	6.49	Yes	No	0	6	7
1032	S:S:F383	S:S:L382	9.74	No	No	0	7	5
1033	S:S:N384	S:S:Y387	5.81	No	Yes	0	9	8
1034	S:S:K385	S:S:R388	11.14	No	No	0	5	9
1035	S:S:K385	S:S:S389	7.65	No	No	0	5	4
1036	S:S:F391	S:S:Y387	5.16	Yes	Yes	5	6	8
1037	S:S:A390	S:S:Y394	5.34	No	Yes	0	7	4
1038	S:S:R393	S:S:Y394	8.23	Yes	Yes	5	4	4
1039	S:S:R393	S:S:Y399	6.17	Yes	No	5	4	2
1040	S:S:Y394	S:S:Y399	8.94	Yes	No	5	4	2
1041	P:P:I85	P:P:I89	1.47	Yes	No	0	6	5
1042	P:P:I89	P:P:I93	1.47	No	No	0	5	3
1043	P:P:L171	P:P:T253	1.47	No	No	0	6	5
1044	P:P:I202	P:P:I206	1.47	No	Yes	0	5	6
1045	P:P:I344	P:P:I348	1.47	No	No	0	5	4
1046	R:R:L171	R:R:T253	1.47	No	No	0	6	5
1047	R:R:I196	R:R:I197	1.47	No	No	0	8	2
1048	S:S:L171	S:S:T253	1.47	No	No	0	6	5
1049	S:S:I196	S:S:I197	1.47	Yes	No	0	8	2
1050	P:P:I315	P:P:M312	1.46	No	No	0	5	4
1051	S:S:I315	S:S:M312	1.46	No	No	0	5	4
1052	P:P:G138	P:P:Y139	1.45	No	No	0	5	3
1053	P:P:E318	P:P:S314	1.44	No	No	0	8	5
1054	S:S:E264	S:S:S260	1.44	No	No	0	7	6
1055	S:S:E351	S:S:S352	1.44	No	No	0	5	2
1056	P:P:I395	P:P:L94	1.43	No	No	0	6	6
1057	P:P:I237	S:S:L69	1.43	No	No	0	4	2
1058	R:R:Q106	R:R:V99	1.43	No	Yes	0	7	7
1059	S:S:I86	S:S:L87	1.43	No	No	0	4	4
1060	S:S:I395	S:S:L94	1.43	No	No	0	6	6
1061	R:R:N75	S:S:M208	1.4	No	No	0	5	4
1062	P:P:C322	P:P:R173	1.39	No	Yes	0	7	9
1063	S:S:A108	S:S:F112	1.39	No	Yes	1	5	8
1064	S:S:A192	S:S:F112	1.39	No	Yes	1	7	8
1065	P:P:A321	P:P:R173	1.38	No	Yes	0	8	9
1066	R:R:L79	R:R:L80	1.38	Yes	No	0	4	4
1067	S:S:L79	S:S:L80	1.38	Yes	No	0	4	4
1068	P:P:I237	S:S:Q72	1.37	No	No	0	4	1
1069	P:P:I258	P:P:Q262	1.37	No	No	0	5	6
1070	P:P:E264	P:P:I315	1.37	No	No	0	7	5
1071	P:P:I395	P:P:Q396	1.37	No	No	0	6	4
1072	R:R:I315	R:R:Q319	1.37	No	No	0	5	5
1073	P:P:K103	P:P:Q106	1.36	No	No	0	6	7
1074	R:R:K103	R:R:Q106	1.36	No	No	0	6	7
1075	S:S:K259	S:S:Q262	1.36	No	No	0	4	6
1076	R:R:D231	R:R:N233	1.35	No	No	0	5	3
1077	S:S:E102	S:S:K103	1.35	Yes	No	0	6	6
1078	S:S:D356	S:S:N354	1.35	No	No	0	2	1
1079	P:P:E318	P:P:L261	1.33	No	No	0	8	8
1080	P:P:N317	P:P:Q313	1.32	No	No	0	6	5
1081	R:R:N179	R:R:Q178	1.32	No	No	0	6	6
1082	R:R:N317	R:R:Q313	1.32	No	No	0	6	5
1083	P:P:H70	P:P:K74	1.31	No	No	0	3	6
1084	R:R:E318	R:R:N317	1.31	No	No	0	8	6
1085	R:R:F193	R:R:T190	1.3	No	Yes	0	4	5
1086	S:S:R388	S:S:T381	1.29	No	No	0	9	7
1087	R:R:S226	R:R:Y139	1.27	No	Yes	0	4	3
1088	S:S:S260	S:S:Y174	1.27	No	No	0	6	8
1089	P:P:F125	P:P:I89	1.26	No	No	0	4	5
1090	S:S:V150	S:S:Y153	1.26	No	Yes	0	4	6
1091	S:S:K400	S:S:R393	1.24	No	Yes	0	3	4
1092	S:S:E73	S:S:H70	1.23	No	No	0	3	3
1093	R:R:F330	R:R:L331	1.22	No	No	0	5	6
1094	P:P:L136	P:P:Y137	1.17	No	No	0	5	4
1095	R:R:L136	R:R:Y137	1.17	No	No	0	5	4
1096	R:R:N75	R:R:W76	1.13	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.57308	13	3	0
2	M:M:?1	7.74733	15	1	0
3	P:P:V84	3.275	4	2	7
4	P:P:I85	2.46429	7	2	6
5	P:P:T88	3.48	5	2	7
6	P:P:V95	3.67	4	0	9
7	P:P:I96	3.3375	4	0	6
8	P:P:E102	4.4725	4	7	6
9	P:P:L105	4.982	5	7	8
10	P:P:N110	5.5475	4	7	9
11	P:P:Y111	6.524	5	9	4
12	P:P:F112	6.016	5	2	8
13	P:P:S115	6.385	4	2	9
14	P:P:D120	7.528	5	0	9
15	P:P:L123	3.706	5	0	7
16	P:P:G124	2.6325	4	2	6
17	P:P:V127	5.994	5	2	8
18	P:P:M128	4.13143	7	2	8
19	P:P:I135	4.7425	4	2	5
20	P:P:W141	6.445	8	2	7
21	P:P:P142	6.21	5	2	3
22	P:P:L143	4.505	4	2	5
23	P:P:C148	5.982	5	2	9
24	P:P:W151	5.015	8	2	5
25	P:P:I152	3.16429	7	2	5
26	P:P:Y153	5.95	5	2	6
27	P:P:L154	2.74	4	2	5
28	P:P:D155	10.4575	4	2	8
29	P:P:V156	4.43	4	2	6
30	P:P:L157	4.59833	6	2	6
31	P:P:F158	5.232	5	2	7
32	P:P:T160	2.49	5	2	7
33	P:P:I163	3.74	6	2	8
34	P:P:M164	3.12	4	2	6
35	P:P:H165	9.38	4	2	8
36	P:P:L166	4.702	5	2	8
37	P:P:R173	4.22	4	0	9
38	P:P:V199	3.6325	4	2	6
39	P:P:W200	5.37333	6	2	9
40	P:P:S203	3.188	5	2	8
41	P:P:I206	1.9025	4	2	6
42	P:P:S207	4.97	4	2	7
43	P:P:M208	4.0675	4	6	4
44	P:P:I210	3.945	4	2	6
45	P:P:K220	7.9	5	6	3
46	P:P:V221	3.3225	4	2	3
47	P:P:C227	4.28	5	2	9
48	P:P:S242	2.45	5	2	6
49	P:P:F243	6.15571	7	2	8
50	P:P:F244	5.985	4	2	5
51	P:P:P246	3.8475	4	0	9
52	P:P:M250	4.194	5	2	8
53	P:P:L325	3.8225	4	2	8
54	P:P:V328	2.326	5	2	8
55	P:P:F329	5.2275	8	2	8
56	P:P:F332	5.75	5	2	9
57	P:P:W336	7.8425	8	2	8
58	P:P:F339	7.508	5	2	7
59	P:P:F340	11.1833	6	2	7
60	P:P:L362	4.0225	4	0	3
61	P:P:N363	6.91	4	2	4
62	P:P:F365	5.955	4	0	5
63	P:P:V366	4.8475	4	2	6
64	P:P:W367	5.41444	9	2	6
65	P:P:Y370	7.97714	7	2	7
66	P:P:S373	3.76	4	0	9
67	P:P:P377	5.97	4	0	9
68	P:P:V379	3.715	4	2	8
69	P:P:Y380	7.845	4	0	9
70	P:P:F383	3.155	4	2	7
71	P:P:Y387	6.75143	7	7	8
72	P:P:F391	5.8625	4	0	6
73	P:P:Y394	4.1825	4	7	4
74	R:R:L79	1.5175	4	0	4
75	R:R:I85	4.76	4	3	6
76	R:R:T88	3.18	4	3	7
77	R:R:V95	3.51	5	0	9
78	R:R:A98	2.475	4	4	7
79	R:R:V99	3.02	6	4	7
80	R:R:L105	6.8825	4	4	8
81	R:R:N110	5.7525	4	4	9
82	R:R:F112	6.01	4	12	8
83	R:R:L116	4.71	4	3	9
84	R:R:D120	5.56833	6	3	9
85	R:R:L123	3.47714	7	3	7
86	R:R:V127	4.234	5	3	8
87	R:R:M128	3.96444	9	3	8
88	R:R:Y139	6.748	5	0	3
89	R:R:W141	6	9	3	7
90	R:R:P142	6.676	5	3	3
91	R:R:L143	4.534	5	3	5
92	R:R:L147	4.475	4	3	5
93	R:R:C148	6.6375	4	3	9
94	R:R:W151	4.96143	7	3	5
95	R:R:I152	3.59667	6	3	5
96	R:R:Y153	4.128	5	3	6
97	R:R:D155	10.4825	4	3	8
98	R:R:V156	4.335	4	3	6
99	R:R:L157	4.5175	4	0	6
100	R:R:F158	6.625	6	3	7
101	R:R:T160	2.526	5	3	7
102	R:R:S162	2.5725	4	3	9
103	R:R:H165	8.948	5	3	8
104	R:R:L166	3.892	5	3	8
105	R:R:R173	5.0325	4	11	9
106	R:R:Y174	3.64	5	0	8
107	R:R:T190	3.29	4	15	5
108	R:R:W200	5.7375	4	3	9
109	R:R:V204	2.215	4	3	4
110	R:R:S207	3.9225	4	0	7
111	R:R:M208	1.8175	4	3	4
112	R:R:I210	3.292	5	3	6
113	R:R:V221	2.4225	4	3	3
114	R:R:C227	3.692	5	3	9
115	R:R:L229	4.504	5	3	4
116	R:R:V235	2.88	4	3	6
117	R:R:S242	2.8825	4	3	6
118	R:R:F243	9.2025	4	3	8
119	R:R:F244	5.8125	4	3	5
120	R:R:M250	4.955	4	3	8
121	R:R:Y254	8.9425	4	3	9
122	R:R:I327	4.3025	4	8	6
123	R:R:F329	6.20333	6	3	8
124	R:R:F332	5.198	5	3	9
125	R:R:M335	1.895	4	0	8
126	R:R:W336	6.52	9	3	8
127	R:R:F339	5.36	6	3	7
128	R:R:F340	9.68833	6	3	7
129	R:R:N343	3.435	4	3	7
130	R:R:V347	3.395	4	0	5
131	R:R:C349	3.04	4	17	3
132	R:R:I358	3.28	4	18	4
133	R:R:L362	3.97	4	3	3
134	R:R:F365	5.988	5	3	5
135	R:R:V366	3.47	4	3	6
136	R:R:W367	5.70875	8	3	6
137	R:R:Y370	5.62375	8	3	7
138	R:R:S372	2.455	4	3	9
139	R:R:S373	3.3975	4	3	9
140	R:R:N376	6.5225	4	0	9
141	R:R:P377	5.565	4	0	9
142	R:R:V379	4.03	4	8	8
143	R:R:Y380	7.5625	4	4	9
144	R:R:F383	4.794	5	8	7
145	R:R:Y387	7.24625	8	4	8
146	R:R:F391	6.334	5	4	6
147	R:R:Y394	4.968	5	4	4
148	S:S:L71	6.155	4	6	3
149	S:S:K74	3.73	5	6	6
150	S:S:N75	5.514	5	6	5
151	S:S:L79	2.8	4	0	4
152	S:S:V84	2.85	4	1	7
153	S:S:I85	4.4	4	1	6
154	S:S:T88	2.38833	6	1	7
155	S:S:V95	4.5925	4	0	9
156	S:S:V99	4.2325	4	5	7
157	S:S:E102	5.272	5	5	6
158	S:S:L105	5.348	5	5	8
159	S:S:Y111	4.8175	4	5	4
160	S:S:F112	4.566	5	1	8
161	S:S:S115	4.14	4	1	9
162	S:S:L116	4.37	4	1	9
163	S:S:D120	6.0425	4	1	9
164	S:S:L123	2.568	5	0	7
165	S:S:V127	3.77333	6	1	8
166	S:S:M128	4.18375	8	1	8
167	S:S:V130	4.755	4	1	4
168	S:S:I135	3.7725	4	1	5
169	S:S:W141	6.59125	8	1	7
170	S:S:P142	5.026	5	1	3
171	S:S:L143	3.7225	4	1	5
172	S:S:C148	6.26	5	1	9
173	S:S:W151	5.2	6	1	5
174	S:S:I152	3.52	7	1	5
175	S:S:Y153	6.804	5	1	6
176	S:S:D155	9.895	4	1	8
177	S:S:V156	3.6425	4	1	6
178	S:S:L157	5.13	4	0	6
179	S:S:F158	5.3725	4	0	7
180	S:S:S162	2.9425	4	1	9
181	S:S:I163	3.135	4	0	8
182	S:S:H165	7.145	4	1	8
183	S:S:L166	3.648	5	1	8
184	S:S:R173	3.495	4	19	9
185	S:S:I196	3.2275	4	1	8
186	S:S:W200	3.82167	6	1	9
187	S:S:I210	4.62	5	1	6
188	S:S:F213	7.786	5	1	4
189	S:S:V221	2.7375	4	1	3
190	S:S:F222	4.2	4	1	2
191	S:S:C227	5.254	5	1	9
192	S:S:L229	3.91833	6	1	4
193	S:S:F234	8.9375	4	1	7
194	S:S:V235	2.575	4	1	6
195	S:S:S239	3.208	5	1	6
196	S:S:F243	7.642	5	1	8
197	S:S:M250	6.075	4	1	8
198	S:S:Y254	7.3675	4	0	9
199	S:S:I258	5.3575	4	0	5
200	S:S:V328	3.2325	4	1	8
201	S:S:F329	6.546	5	1	8
202	S:S:F332	5.61	5	1	9
203	S:S:V333	2.2825	4	0	6
204	S:S:M335	1.9875	4	0	8
205	S:S:W336	7.30286	7	1	8
206	S:S:F339	7.38167	6	1	7
207	S:S:F340	9.945	6	1	7
208	S:S:N343	4.074	5	1	7
209	S:S:E355	2.4575	4	1	3
210	S:S:I358	2.764	5	1	4
211	S:S:F365	5.93	4	0	5
212	S:S:W367	6.76875	8	1	6
213	S:S:Y370	6.15857	7	1	7
214	S:S:S372	3.4225	4	1	9
215	S:S:S373	3.942	5	1	9
216	S:S:P377	3.802	5	0	9
217	S:S:Y380	9.305	4	0	9
218	S:S:Y387	6.87714	7	5	8
219	S:S:F391	6.574	5	5	6
220	S:S:R393	5.0725	4	5	4
221	S:S:Y394	7.58	5	5	4
222	U:U:?1	7.50357	14	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y370	16.8217	3.13	Yes	Yes	3	0	7
2	R:R:M128	R:R:Y370	27.3712	7.18	Yes	Yes	3	8	7
3	R:R:M128	R:R:T88	44.8127	6.02	Yes	Yes	3	8	7
4	R:R:A374	R:R:T88	94.3702	1.68	No	Yes	0	6	7
5	R:R:A374	R:R:L87	94.5043	1.58	No	No	0	6	4
6	R:R:L87	R:R:V83	94.6382	2.98	No	No	0	4	4
7	R:R:L79	R:R:V83	94.9053	1.49	Yes	No	0	4	4
8	R:R:L79	S:S:V204	95.3046	1.49	Yes	No	0	4	4
9	S:S:L157	S:S:V204	95.4373	2.98	Yes	No	0	6	4
10	S:S:F158	S:S:L157	88.8917	8.53	Yes	Yes	0	7	6
11	S:S:F158	S:S:L123	85.4118	3.65	Yes	Yes	0	7	7
12	S:S:L123	S:S:V127	26.6488	2.98	Yes	Yes	0	7	8
13	S:S:L123	S:S:S373	30.2358	1.5	Yes	Yes	0	7	9
14	S:S:V127	S:S:Y370	26.1341	2.52	Yes	Yes	1	8	7
15	S:S:G124	S:S:L123	26.1768	1.71	No	Yes	0	6	7
16	S:S:G124	S:S:M128	25.5106	5.24	No	Yes	1	6	8
17	S:S:M128	S:S:W367	61.9178	3.49	Yes	Yes	1	8	6
18	S:S:I135	S:S:W367	98.4173	2.35	Yes	Yes	1	5	6
19	S:S:I135	S:S:S77	97.7212	1.55	Yes	No	0	5	3
20	S:S:K74	S:S:S77	97.9984	1.53	Yes	No	0	6	3
21	S:S:K74	S:S:L71	98.5215	5.64	Yes	Yes	6	6	3
22	P:P:F213	S:S:L71	100	9.74	No	Yes	6	4	3
23	P:P:F213	P:P:K220	99.3803	12.41	No	Yes	6	4	3
24	P:P:F234	P:P:K220	98.6257	6.2	No	Yes	6	7	3
25	P:P:F234	S:S:Q72	98.5344	4.68	No	No	0	7	1
26	P:P:I237	S:S:Q72	98.3555	1.37	No	No	0	4	1
27	P:P:G238	P:P:I237	97.998	3.53	No	No	0	6	4
28	P:P:G238	P:P:S242	97.8188	1.86	No	Yes	0	6	6
29	P:P:S242	U:U:?1	60.8816	4.01	Yes	Yes	2	6	0
30	S:S:M128	S:S:S373	37.0848	3.07	Yes	Yes	1	8	9
31	S:S:W367	S:S:Y370	32.3714	10.61	Yes	Yes	1	6	7
32	P:P:F332	U:U:?1	23.9055	1.63	Yes	Yes	2	9	0
33	P:P:F332	P:P:L166	24.2694	6.09	Yes	Yes	2	9	8
34	P:P:L166	P:P:V328	15.8686	1.49	Yes	Yes	2	8	8
35	P:P:V328	P:P:V379	10.0638	1.6	Yes	Yes	2	8	8
36	P:P:S242	P:P:T160	36.1182	1.6	Yes	Yes	2	6	7
37	P:P:I118	P:P:S115	14.6476	1.55	No	Yes	0	6	9
38	P:P:I118	P:P:I96	13.7358	5.89	No	Yes	0	6	6
39	P:P:S203	P:P:T160	16.8179	4.8	Yes	Yes	2	8	7
40	P:P:I96	P:P:M114	13.1291	2.92	Yes	No	0	6	5
41	P:P:M114	P:P:Y111	12.2695	2.39	No	Yes	0	5	4
42	P:P:I163	P:P:T160	11.3001	1.52	Yes	Yes	2	8	7
43	S:S:D120	S:S:S373	13.0012	10.31	Yes	Yes	1	9	9
44	S:S:D120	S:S:N92	11.2574	6.73	Yes	No	0	9	9
45	R:R:D120	R:R:S373	36.4809	7.36	Yes	Yes	3	9	9
46	R:R:D120	R:R:N376	16.4105	4.04	Yes	Yes	0	9	9
47	R:R:N376	R:R:Y380	11.2724	8.14	Yes	Yes	0	9	9
48	R:R:V127	R:R:W151	10.9674	4.9	Yes	Yes	3	8	5
49	R:R:W141	R:R:W151	13.8669	10.31	Yes	Yes	3	7	5
50	R:R:L123	R:R:V127	12.5792	4.47	Yes	Yes	3	7	8
51	R:R:S373	R:R:T88	42.0625	3.2	Yes	Yes	3	9	7
52	R:R:D120	R:R:L116	12.8559	4.07	Yes	Yes	3	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
P:P:L123	P:P:V127	7.45	0	Yes	Yes	7	8	2	2
P:P:L123	P:P:S159	3	0	Yes	No	7	7	2	1
P:P:V127	P:P:W151	4.9	2	Yes	Yes	8	5	2	1
P:P:D155	P:P:V127	13.15	2	Yes	Yes	8	8	1	2
P:P:M128	P:P:W367	3.49	2	Yes	Yes	8	6	2	2
P:P:M128	P:P:Y370	3.59	2	Yes	Yes	8	7	2	1
P:P:V130	P:P:W141	3.68	2	No	Yes	4	7	2	2
P:P:V130	P:P:W151	6.13	2	No	Yes	4	5	2	1
P:P:S131	P:P:W151	3.71	2	No	Yes	7	5	2	1
P:P:S131	P:P:W367	4.94	2	No	Yes	7	6	2	2
P:P:S131	P:P:Y370	8.9	2	No	Yes	7	7	2	1
P:P:W141	P:P:W151	12.18	2	Yes	Yes	7	5	2	1
P:P:C227	P:P:W141	3.92	2	Yes	Yes	9	7	2	2
P:P:I152	P:P:W151	2.35	2	Yes	Yes	5	5	2	1
P:P:D155	P:P:W151	3.35	2	Yes	Yes	8	5	1	1
P:P:C227	P:P:W151	5.22	2	Yes	Yes	9	5	2	1
P:P:W151	U:U:?1	2.28	2	Yes	Yes	5	0	1	0
P:P:I152	P:P:V156	1.54	2	Yes	Yes	5	6	2	1
P:P:I152	P:P:I210	2.94	2	Yes	Yes	5	6	2	2
P:P:C227	P:P:I152	3.27	2	Yes	Yes	9	5	2	2
P:P:I152	P:P:L229	5.71	2	Yes	No	5	4	2	1
P:P:D155	P:P:Y370	12.64	2	Yes	Yes	8	7	1	1
P:P:D155	U:U:?1	12.69	2	Yes	Yes	8	0	1	0
P:P:S207	P:P:V156	1.62	2	Yes	Yes	7	6	2	1
P:P:I210	P:P:V156	4.61	2	Yes	Yes	6	6	2	1
P:P:V156	U:U:?1	9.95	2	Yes	Yes	6	0	1	0
P:P:S159	U:U:?1	12.03	0	No	Yes	7	0	1	0
P:P:I163	P:P:T160	1.52	2	Yes	Yes	8	7	2	2
P:P:I206	P:P:T160	1.52	2	Yes	Yes	6	7	2	2
P:P:S242	P:P:T160	1.6	2	Yes	Yes	6	7	1	2
P:P:F243	P:P:I163	2.51	2	Yes	Yes	8	8	1	2
P:P:F332	P:P:I163	8.79	2	Yes	Yes	9	8	1	2
P:P:F332	P:P:L166	6.09	2	Yes	Yes	9	8	1	2
P:P:I206	P:P:V241	3.07	2	Yes	No	6	4	2	2
P:P:I206	P:P:S242	1.55	2	Yes	Yes	6	6	2	1
P:P:L229	P:P:V235	2.98	2	No	No	4	6	1	1
P:P:L229	U:U:?1	4.62	2	No	Yes	4	0	1	0
P:P:V235	P:P:V347	3.21	2	No	No	6	5	1	2
P:P:V235	U:U:?1	3.98	2	No	Yes	6	0	1	0
P:P:G238	P:P:S242	1.86	0	No	Yes	6	6	2	1
P:P:F340	P:P:S239	5.28	2	Yes	No	7	6	1	1
P:P:I344	P:P:S239	3.1	0	No	No	5	6	2	1
P:P:S239	U:U:?1	3.01	2	No	Yes	6	0	1	0
P:P:S242	P:P:V241	3.23	2	Yes	No	6	4	1	2
P:P:S242	U:U:?1	4.01	2	Yes	Yes	6	0	1	0
P:P:F243	P:P:F244	8.57	2	Yes	Yes	8	5	1	2
P:P:F243	P:P:F332	3.22	2	Yes	Yes	8	9	1	1
P:P:F243	P:P:W336	4.01	2	Yes	Yes	8	8	1	1
P:P:C337	P:P:F243	2.79	0	No	Yes	6	8	2	1
P:P:F243	P:P:F340	20.36	2	Yes	Yes	8	7	1	1
P:P:F243	U:U:?1	1.63	2	Yes	Yes	8	0	1	0
P:P:F244	P:P:F340	2.14	2	Yes	Yes	5	7	2	1
P:P:F332	P:P:W336	9.02	2	Yes	Yes	9	8	1	1
P:P:F332	U:U:?1	1.63	2	Yes	Yes	9	0	1	0
P:P:F339	P:P:W336	8.02	2	Yes	Yes	7	8	1	1
P:P:F340	P:P:W336	5.01	2	Yes	Yes	7	8	1	1
P:P:G369	P:P:W336	12.67	0	No	Yes	7	8	2	1
P:P:W336	P:P:Y370	3.86	2	Yes	Yes	8	7	1	1
P:P:S372	P:P:W336	4.94	0	No	Yes	9	8	2	1
P:P:W336	U:U:?1	15.21	2	Yes	Yes	8	0	1	0
P:P:F339	P:P:F340	10.72	2	Yes	Yes	7	7	1	1
P:P:F339	P:P:N343	9.67	2	Yes	No	7	7	1	2
P:P:F339	P:P:V366	2.62	2	Yes	Yes	7	6	1	2
P:P:F339	U:U:?1	6.51	2	Yes	Yes	7	0	1	0
P:P:F340	U:U:?1	23.59	2	Yes	Yes	7	0	1	0
P:P:V366	P:P:W367	2.45	2	Yes	Yes	6	6	2	2
P:P:V366	P:P:Y370	11.36	2	Yes	Yes	6	7	2	1
P:P:W367	P:P:Y370	11.58	2	Yes	Yes	6	7	2	1
P:P:Y370	U:U:?1	3.91	2	Yes	Yes	7	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
M:M:?1	S:S:W151	3.8	1	Yes	Yes	0	5	0	1
M:M:?1	S:S:D155	17.22	1	Yes	Yes	0	8	0	1
M:M:?1	S:S:V156	9.95	1	Yes	Yes	0	6	0	1
M:M:?1	S:S:S159	12.03	1	Yes	No	0	7	0	1
M:M:?1	S:S:T160	2.95	1	Yes	No	0	7	0	1
M:M:?1	S:S:L229	8.32	1	Yes	Yes	0	4	0	1
M:M:?1	S:S:V235	3.98	1	Yes	Yes	0	6	0	1
M:M:?1	S:S:G238	2.28	1	Yes	No	0	6	0	1
M:M:?1	S:S:S239	3.01	1	Yes	Yes	0	6	0	1
M:M:?1	S:S:S242	6.02	1	Yes	No	0	6	0	1
M:M:?1	S:S:W336	13.69	1	Yes	Yes	0	8	0	1
M:M:?1	S:S:F339	8.95	1	Yes	Yes	0	7	0	1
M:M:?1	S:S:F340	17.08	1	Yes	Yes	0	7	0	1
M:M:?1	S:S:N343	4.58	1	Yes	Yes	0	7	0	1
M:M:?1	S:S:Y370	2.35	1	Yes	Yes	0	7	0	1
S:S:L123	S:S:V127	2.98	0	Yes	Yes	7	8	2	2
S:S:L123	S:S:S159	3	0	Yes	No	7	7	2	1
S:S:V127	S:S:W151	2.45	1	Yes	Yes	8	5	2	1
S:S:D155	S:S:V127	10.22	1	Yes	Yes	8	8	1	2
S:S:V127	S:S:Y370	2.52	1	Yes	Yes	8	7	2	1
S:S:M128	S:S:W367	3.49	1	Yes	Yes	8	6	2	2
S:S:M128	S:S:Y370	9.58	1	Yes	Yes	8	7	2	1
S:S:V130	S:S:W141	3.68	1	Yes	Yes	4	7	2	2
S:S:V130	S:S:W151	12.26	1	Yes	Yes	4	5	2	1
S:S:S131	S:S:W367	7.41	1	No	Yes	7	6	2	2
S:S:S131	S:S:Y370	2.54	1	No	Yes	7	7	2	1
S:S:C148	S:S:W141	16.98	1	Yes	Yes	9	7	2	2
S:S:W141	S:S:W151	6.56	1	Yes	Yes	7	5	2	1
S:S:C148	S:S:W151	2.61	1	Yes	Yes	9	5	2	1
S:S:C148	S:S:I152	1.64	1	Yes	Yes	9	5	2	2
S:S:I152	S:S:W151	3.52	1	Yes	Yes	5	5	2	1
S:S:I152	S:S:V156	1.54	1	Yes	Yes	5	6	2	1
S:S:I152	S:S:I210	5.89	1	Yes	Yes	5	6	2	2
S:S:I152	S:S:L229	5.71	1	Yes	Yes	5	4	2	1
S:S:D155	S:S:S159	2.94	1	Yes	No	8	7	1	1
S:S:D155	S:S:Y370	9.2	1	Yes	Yes	8	7	1	1
S:S:T160	S:S:V156	1.59	1	No	Yes	7	6	1	1
S:S:L229	S:S:V156	1.49	1	Yes	Yes	4	6	1	1
S:S:S242	S:S:T160	7.99	1	No	No	6	7	1	1
S:S:I210	S:S:L229	2.85	1	Yes	Yes	6	4	2	1
S:S:F234	S:S:L229	3.65	1	Yes	Yes	7	4	2	1
S:S:L229	S:S:V235	1.49	1	Yes	Yes	4	6	1	1
S:S:S239	S:S:V235	1.62	1	Yes	Yes	6	6	1	1
S:S:V235	S:S:V347	3.21	1	Yes	No	6	5	1	2
S:S:G238	S:S:I237	1.76	0	No	No	6	4	1	2
S:S:F340	S:S:S239	5.28	1	Yes	Yes	7	6	1	1
S:S:N343	S:S:S239	1.49	1	Yes	Yes	7	6	1	1
S:S:I344	S:S:S239	4.64	0	No	Yes	5	6	2	1
S:S:F243	S:S:F244	9.65	1	Yes	No	8	5	2	2
S:S:F243	S:S:W336	2	1	Yes	Yes	8	8	2	1
S:S:F243	S:S:F340	21.43	1	Yes	Yes	8	7	2	1
S:S:F244	S:S:F340	3.22	1	No	Yes	5	7	2	1
S:S:F332	S:S:W336	9.02	1	Yes	Yes	9	8	2	1
S:S:F332	S:S:S372	5.28	1	Yes	Yes	9	9	2	2
S:S:F339	S:S:W336	7.02	1	Yes	Yes	7	8	1	1
S:S:F340	S:S:W336	3.01	1	Yes	Yes	7	8	1	1
S:S:G369	S:S:W336	12.67	0	No	Yes	7	8	2	1
S:S:S372	S:S:W336	3.71	1	Yes	Yes	9	8	2	1
S:S:F339	S:S:F340	9.65	1	Yes	Yes	7	7	1	1
S:S:F339	S:S:N343	7.25	1	Yes	Yes	7	7	1	1
S:S:F339	S:S:L362	4.87	1	Yes	No	7	3	1	2
S:S:F339	S:S:V366	6.55	1	Yes	No	7	6	1	2
S:S:A346	S:S:N343	1.56	1	No	Yes	4	7	2	1
S:S:L362	S:S:N343	5.49	1	No	Yes	3	7	2	1
S:S:V366	S:S:W367	3.68	1	No	Yes	6	6	2	2
S:S:V366	S:S:Y370	6.31	1	No	Yes	6	7	2	1
S:S:W367	S:S:Y370	10.61	1	Yes	Yes	6	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:W151	2.28	3	Yes	Yes	0	5	0	1
L:L:?1	R:R:D155	19.03	3	Yes	Yes	0	8	0	1
L:L:?1	R:R:V156	7.96	3	Yes	Yes	0	6	0	1
L:L:?1	R:R:S159	14.04	3	Yes	No	0	7	0	1
L:L:?1	R:R:I163	3.81	3	Yes	No	0	8	0	1
L:L:?1	R:R:L229	4.62	3	Yes	Yes	0	4	0	1
L:L:?1	R:R:V235	3.98	3	Yes	Yes	0	6	0	1
L:L:?1	R:R:S242	2.01	3	Yes	Yes	0	6	0	1
L:L:?1	R:R:W336	12.17	3	Yes	Yes	0	8	0	1
L:L:?1	R:R:F339	6.51	3	Yes	Yes	0	7	0	1
L:L:?1	R:R:F340	17.08	3	Yes	Yes	0	7	0	1
L:L:?1	R:R:N343	1.83	3	Yes	Yes	0	7	0	1
L:L:?1	R:R:Y370	3.13	3	Yes	Yes	0	7	0	1
R:R:L123	R:R:V127	4.47	3	Yes	Yes	7	8	2	2
R:R:L123	R:R:M128	2.83	3	Yes	Yes	7	8	2	2
R:R:L123	R:R:S159	3	3	Yes	No	7	7	2	1
R:R:L123	R:R:Y370	3.52	3	Yes	Yes	7	7	2	1
R:R:V127	R:R:W151	4.9	3	Yes	Yes	8	5	2	1
R:R:D155	R:R:V127	5.84	3	Yes	Yes	8	8	1	2
R:R:M128	R:R:W367	2.33	3	Yes	Yes	8	6	2	2
R:R:M128	R:R:Y370	7.18	3	Yes	Yes	8	7	2	1
R:R:V130	R:R:W141	2.45	3	No	Yes	4	7	2	2
R:R:V130	R:R:W151	9.81	3	No	Yes	4	5	2	1
R:R:S131	R:R:W151	2.47	3	No	Yes	7	5	2	1
R:R:S131	R:R:W367	6.18	3	No	Yes	7	6	2	2
R:R:S131	R:R:Y370	3.82	3	No	Yes	7	7	2	1
R:R:W141	R:R:W151	10.31	3	Yes	Yes	7	5	2	1
R:R:C227	R:R:W141	5.22	3	Yes	Yes	9	7	2	2
R:R:I152	R:R:W151	2.35	3	Yes	Yes	5	5	2	1
R:R:C227	R:R:W151	2.61	3	Yes	Yes	9	5	2	1
R:R:I152	R:R:V156	1.54	3	Yes	Yes	5	6	2	1
R:R:I152	R:R:I210	4.42	3	Yes	Yes	5	6	2	2
R:R:I152	R:R:V221	3.07	3	Yes	Yes	5	3	2	2
R:R:C227	R:R:I152	1.64	3	Yes	Yes	9	5	2	2
R:R:I152	R:R:L229	8.56	3	Yes	Yes	5	4	2	1
R:R:D155	R:R:S159	4.42	3	Yes	No	8	7	1	1
R:R:D155	R:R:Y370	12.64	3	Yes	Yes	8	7	1	1
R:R:S207	R:R:V156	3.23	0	Yes	Yes	7	6	2	1
R:R:I210	R:R:V156	4.61	3	Yes	Yes	6	6	2	1
R:R:I206	R:R:T160	1.52	3	No	Yes	6	7	2	2
R:R:S207	R:R:T160	1.6	0	Yes	Yes	7	7	2	2
R:R:S242	R:R:T160	4.8	3	Yes	Yes	6	7	1	2
R:R:I163	R:R:P246	5.08	0	No	No	8	9	1	2
R:R:F332	R:R:I163	6.28	3	Yes	No	9	8	2	1
R:R:I206	R:R:V241	4.61	3	No	No	6	4	2	2
R:R:I206	R:R:S242	3.1	3	No	Yes	6	6	2	1
R:R:C227	R:R:V221	1.71	3	Yes	Yes	9	3	2	2
R:R:L229	R:R:V221	1.49	3	Yes	Yes	4	3	1	2
R:R:F234	R:R:L229	4.87	0	No	Yes	7	4	2	1
R:R:L229	R:R:V235	2.98	3	Yes	Yes	4	6	1	1
R:R:N343	R:R:V235	2.96	3	Yes	Yes	7	6	1	1
R:R:V235	R:R:V347	1.6	3	Yes	Yes	6	5	1	2
R:R:F244	R:R:S239	3.96	3	Yes	No	5	6	2	2
R:R:F340	R:R:S239	3.96	3	Yes	No	7	6	1	2
R:R:S242	R:R:V241	1.62	3	Yes	No	6	4	1	2
R:R:F243	R:R:F244	7.5	3	Yes	Yes	8	5	2	2
R:R:F243	R:R:W336	4.01	3	Yes	Yes	8	8	2	1
R:R:F243	R:R:F340	22.51	3	Yes	Yes	8	7	2	1
R:R:F244	R:R:F340	2.14	3	Yes	Yes	5	7	2	1
R:R:F332	R:R:W336	7.02	3	Yes	Yes	9	8	2	1
R:R:F332	R:R:S372	3.96	3	Yes	Yes	9	9	2	2
R:R:F339	R:R:W336	8.02	3	Yes	Yes	7	8	1	1
R:R:F340	R:R:W336	6.01	3	Yes	Yes	7	8	1	1
R:R:V366	R:R:W336	2.45	3	Yes	Yes	6	8	2	1
R:R:G369	R:R:W336	12.67	3	No	Yes	7	8	2	1
R:R:W336	R:R:Y370	3.86	3	Yes	Yes	8	7	1	1
R:R:S372	R:R:W336	2.47	3	Yes	Yes	9	8	2	1
R:R:F339	R:R:F340	6.43	3	Yes	Yes	7	7	1	1
R:R:F339	R:R:N343	4.83	3	Yes	Yes	7	7	1	1
R:R:F339	R:R:L362	2.44	3	Yes	Yes	7	3	1	2
R:R:F339	R:R:V366	3.93	3	Yes	Yes	7	6	1	2
R:R:L362	R:R:N343	4.12	3	Yes	Yes	3	7	2	1
R:R:V366	R:R:W367	2.45	3	Yes	Yes	6	6	2	2
R:R:V366	R:R:Y370	5.05	3	Yes	Yes	6	7	2	1
R:R:W367	R:R:Y370	5.79	3	Yes	Yes	6	7	2	1
R:R:G369	R:R:S372	1.86	3	No	Yes	7	9	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6WH4_poly
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.49
Number of Linked Nodes	774
Number of Links	1096
Number of Hubs	222
Number of Links mediated by Hubs	765
Number of Communities	20
Number of Nodes involved in Communities	312
Number of Links involved in Communities	534

Path Summary
Number Of Nodes in MetaPath	53
Number Of Links MetaPath	52
Number of Shortest Paths	1533733
Length Of Smallest Path	3
Average Path Length	26.6542
Length of Longest Path	50
Minimum Path Strength	1.265
Average Path Strength	4.50904
Maximum Path Strength	20.47
Minimum Path Correlation	0.7
Average Path Correlation	0.989247
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	48.6994
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	61.3054
Maximum Path Hubs %	100

Details about the values in these tables can be found in the corresponding documentation page .


Code	89F
PDB Residues	L:L:?1 M:M:?1 U:U:?1
Environment Details	Open EMBL-EBI Page
Code	89F
Name	1-methyl-4-[(5~{S})-3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine
Synonyms	Methiothepin; Metitepine
Identifier
Formula	C20 H24 N2 S2
Molecular Weight	356.548
SMILES
PubChem	7059581
Formal Charge	0
Total Atoms	48
Total Chiral Atoms	1
Total Bonds	51
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P28223
Sequence	>6WH4_poly_Chain_R L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E K K L Q N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G Y R W P L P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N P I H H S R F N S R T K A F L K I I A V W T I S V G I S M P I P V F G L S K V F K E G S C L L A D D N F V L I G S F V S F F I P A T I M V I T Y F L T I K S L Q K E A T M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C K E S C N E D V I G A L L N V F V W I G Y A S S A V N P L V Y T L F N K T Y R S A F S R Y I Q C Q Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6WGT	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WH4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WHA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.36	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WHA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-		3.36	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	8ZMG	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Pimavanserin	-	-	3.4	2024-08-28	doi.org/10.1021/acs.jmedchem.4c01244
	7RAN	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.45	2022-07-06	doi.org/10.1038/s41586-022-05258-z
	7RAN (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-		3.45	2022-07-06	doi.org/10.1038/s41586-022-05258-z
	7VOD	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Cariprazine	-	-	3.3	2021-12-22	doi.org/10.1038/s41593-021-00971-w
	7VOE	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Aripiprazole	-	-	2.9	2021-12-22	doi.org/10.1038/s41593-021-00971-w
	6A93	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Risperidone	-	-	3	2019-02-13	doi.org/10.1038/s41594-018-0180-z
	6A94	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Zotepine	-	-	2.9	2019-02-13	doi.org/10.1038/s41594-018-0180-z
	7WC4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	-	3.2	2022-01-26	doi.org/10.1126/science.abl8615
	7WC5	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	-	3.2	2022-01-26	doi.org/10.1126/science.abl8615
	7WC6	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	2.6	2022-01-26	doi.org/10.1126/science.abl8615
	7WC7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	-	2.6	2022-01-26	doi.org/10.1126/science.abl8615
	7WC8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lumateperone	-	-	2.45	2022-01-26	doi.org/10.1126/science.abl8615
	7WC9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 162421364	-	-	2.5	2022-01-26	doi.org/10.1126/science.abl8615
	8UWL	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.8	2024-05-29	doi.org/10.1126/science.adn6354
	8UWL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-		2.8	2024-05-29	doi.org/10.1126/science.adn6354
	8V6U	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 171392456	-	chim(NtGi2-Gs-CtGq)/β1/γ2	3	2024-05-29	doi.org/10.1126/science.adn6354
	8V6U (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 171392456	-		3	2024-05-29	doi.org/10.1126/science.adn6354
	8JT8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	(R)-IHCH-7179	-	-	2.7	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	9ARX	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	-	3.24	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARY	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.27	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARY (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-		3.27	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARZ	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-	-	3.37	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS0	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS0 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-		3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS1	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-	-	3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS2	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.21	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-		3.21	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS3	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.18	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.06	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS4 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-		3.06	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS5	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-	-	3.34	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS6	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-		3.07	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	-	2.72	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-	-	3.47	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ASA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.12	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ASA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-		3.12	2025-04-02	doi.org/10.1038/s41467-025-57956-7

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