psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E73	R:R:Q72	15.29	No	No	0	3	1
2	R:R:E73	R:R:K74	9.45	No	No	0	3	6
3	R:R:N75	S:S:V212	5.91	No	No	0	5	5
4	R:R:M132	R:R:T81	7.53	No	No	0	6	6
5	R:R:T81	R:R:W367	16.98	No	Yes	0	6	6
6	R:R:V84	R:R:W367	4.9	No	Yes	0	7	6
7	R:R:I85	R:R:M128	5.83	No	Yes	0	6	8
8	R:R:I85	R:R:P129	6.77	No	No	0	6	8
9	R:R:I85	R:R:W367	3.52	No	Yes	0	6	6
10	R:R:M128	R:R:T88	6.02	Yes	No	0	8	7
11	R:R:G91	R:R:P377	4.06	No	Yes	0	8	9
12	R:R:A117	R:R:N92	4.69	No	No	0	9	9
13	R:R:D120	R:R:N92	13.46	Yes	No	0	9	9
14	R:R:N92	R:R:P377	8.15	No	Yes	0	9	9
15	R:R:F391	R:R:L94	14.61	Yes	No	0	6	6
16	R:R:P377	R:R:V95	3.53	Yes	No	0	9	9
17	R:R:V95	R:R:Y380	3.79	No	Yes	0	9	9
18	R:R:F391	R:R:V95	5.24	Yes	No	0	6	9
19	R:R:I118	R:R:I96	5.89	No	No	0	6	6
20	R:R:M97	R:R:Y394	5.99	No	Yes	0	4	4
21	R:R:M114	R:R:V99	4.56	No	No	0	5	7
22	R:R:V99	R:R:Y387	5.05	No	Yes	0	7	8
23	R:R:L101	R:R:S100	4.5	No	No	0	5	1
24	R:R:L101	R:R:Y394	8.21	No	Yes	0	5	4
25	R:R:E102	R:R:R393	10.47	No	No	0	6	4
26	R:R:K103	R:R:Q106	6.78	No	No	0	6	7
27	R:R:L105	R:R:N110	5.49	Yes	No	5	8	9
28	R:R:L105	R:R:N384	4.12	Yes	No	5	8	9
29	R:R:L105	R:R:T386	7.37	Yes	No	5	8	6
30	R:R:L105	R:R:Y387	10.55	Yes	Yes	5	8	8
31	R:R:Q106	R:R:Y111	14.65	No	No	0	7	4
32	R:R:N107	R:R:T109	4.39	No	No	0	7	8
33	R:R:N107	R:R:N110	4.09	No	No	0	7	9
34	R:R:R173	R:R:T109	6.47	Yes	No	0	9	8
35	R:R:N110	R:R:Y387	10.47	No	Yes	5	9	8
36	R:R:A192	R:R:Y111	4	No	No	0	7	4
37	R:R:A168	R:R:F112	4.16	No	No	0	7	8
38	R:R:F112	R:R:I169	10.05	No	No	0	8	9
39	R:R:F112	R:R:K195	11.17	No	No	0	8	6
40	R:R:L113	R:R:Y380	9.38	No	Yes	0	8	9
41	R:R:H165	R:R:S115	11.16	Yes	No	0	8	9
42	R:R:I196	R:R:S115	4.64	No	No	0	8	9
43	R:R:D120	R:R:L116	4.07	Yes	No	0	9	9
44	R:R:H165	R:R:L116	9	Yes	No	0	8	9
45	R:R:D120	R:R:S373	7.36	Yes	No	0	9	9
46	R:R:D120	R:R:N376	4.04	Yes	Yes	0	9	9
47	R:R:F125	R:R:M121	3.73	No	No	0	4	7
48	R:R:F158	R:R:L122	14.61	Yes	No	0	7	7
49	R:R:L123	R:R:V127	4.47	No	Yes	0	7	8
50	R:R:F158	R:R:L123	7.31	Yes	No	0	7	7
51	R:R:L123	R:R:Y370	3.52	No	Yes	0	7	7
52	R:R:G124	R:R:M128	5.24	No	Yes	0	6	8
53	R:R:F125	R:R:L126	4.87	No	No	0	4	5
54	R:R:L126	R:R:L154	6.92	No	No	8	5	5
55	R:R:F158	R:R:L126	3.65	Yes	No	8	7	5
56	R:R:V127	R:R:W151	4.9	Yes	No	0	8	5
57	R:R:L154	R:R:V127	4.47	No	Yes	0	5	8
58	R:R:D155	R:R:V127	5.84	Yes	Yes	0	8	8
59	R:R:M128	R:R:Y370	7.18	Yes	Yes	0	8	7
60	R:R:V130	R:R:W151	9.81	No	No	0	4	5
61	R:R:S131	R:R:W367	6.18	No	Yes	2	7	6
62	R:R:S131	R:R:Y370	3.82	No	Yes	2	7	7
63	R:R:L133	R:R:P142	4.93	No	Yes	0	4	3
64	R:R:P142	R:R:T134	6.99	Yes	No	0	3	5
65	R:R:I135	R:R:Y139	8.46	No	Yes	0	5	3
66	R:R:I135	R:R:W367	3.52	No	Yes	0	5	6
67	R:R:P142	R:R:Y137	11.13	Yes	No	0	3	4
68	R:R:N363	R:R:Y139	18.61	No	Yes	0	4	3
69	R:R:R140	R:R:S226	3.95	No	No	0	4	4
70	R:R:P142	R:R:W141	5.4	Yes	Yes	4	3	7
71	R:R:L143	R:R:W141	4.56	No	Yes	4	5	7
72	R:R:L147	R:R:W141	4.56	Yes	Yes	4	5	7
73	R:R:C148	R:R:W141	13.06	No	Yes	4	9	7
74	R:R:W141	R:R:W151	10.31	Yes	No	0	7	5
75	R:R:F222	R:R:W141	6.01	No	Yes	0	2	7
76	R:R:C227	R:R:W141	5.22	No	Yes	4	9	7
77	R:R:L143	R:R:P142	4.93	No	Yes	4	5	3
78	R:R:L143	R:R:L147	6.92	No	Yes	4	5	5
79	R:R:L147	R:R:P144	4.93	Yes	No	0	5	7
80	R:R:C148	R:R:V221	3.42	No	No	0	9	3
81	R:R:C148	R:R:C227	7.28	No	No	4	9	9
82	R:R:I152	R:R:I210	4.42	No	No	0	5	6
83	R:R:I152	R:R:L229	8.56	No	No	0	5	4
84	R:R:S207	R:R:Y153	6.36	No	No	0	7	6
85	R:R:P211	R:R:Y153	6.95	No	No	0	5	6
86	R:R:F158	R:R:L154	6.09	Yes	No	8	7	5
87	R:R:D155	R:R:S159	4.42	Yes	No	2	8	7
88	R:R:D155	R:R:Y370	12.64	Yes	Yes	2	8	7
89	L:L:?1	R:R:D155	19.03	Yes	Yes	2	0	8
90	R:R:I210	R:R:V156	4.61	No	No	0	6	6
91	L:L:?1	R:R:V156	7.96	Yes	No	0	0	6
92	R:R:F158	R:R:L157	6.09	Yes	Yes	0	7	6
93	R:R:L157	R:R:S203	4.5	Yes	No	0	6	8
94	R:R:L157	R:R:S207	4.5	Yes	No	0	6	7
95	L:L:?1	R:R:S159	14.04	Yes	No	2	0	7
96	R:R:S242	R:R:T160	4.8	No	No	0	6	7
97	R:R:A161	R:R:W200	7.78	No	No	0	8	9
98	R:R:A161	R:R:S203	3.42	No	No	0	8	8
99	R:R:I163	R:R:P246	5.08	No	No	0	8	9
100	R:R:F332	R:R:I163	6.28	Yes	No	0	9	8
101	L:L:?1	R:R:I163	3.81	Yes	No	0	0	8
102	R:R:M164	R:R:P246	6.71	No	No	0	6	9
103	R:R:H165	R:R:V199	11.07	Yes	No	0	8	6
104	R:R:H165	R:R:W200	10.58	Yes	No	0	8	9
105	R:R:L166	R:R:M250	4.24	No	Yes	9	8	8
106	R:R:F329	R:R:L166	4.87	Yes	No	9	8	8
107	R:R:F332	R:R:L166	6.09	Yes	No	0	9	8
108	R:R:S170	R:R:T253	6.4	No	No	0	9	5
109	R:R:F329	R:R:S170	6.61	Yes	No	0	8	9
110	R:R:D172	R:R:K191	4.15	No	No	7	9	6
111	R:R:D172	R:R:K195	12.44	No	No	7	9	6
112	R:R:E318	R:R:R173	4.65	No	Yes	0	8	9
113	R:R:A321	R:R:R173	4.15	No	Yes	0	8	9
114	R:R:L325	R:R:R173	4.86	No	Yes	0	8	9
115	R:R:Q178	R:R:Y174	4.51	No	Yes	0	6	8
116	R:R:T253	R:R:Y174	4.99	No	Yes	0	5	8
117	R:R:L256	R:R:Y174	4.69	No	Yes	0	5	8
118	R:R:T257	R:R:Y174	3.75	No	Yes	0	9	8
119	R:R:I177	R:R:S260	4.64	No	No	10	9	6
120	R:R:I177	R:R:L261	8.56	No	No	0	9	8
121	R:R:E264	R:R:I177	5.47	No	No	10	7	9
122	R:R:Q178	R:R:S260	7.22	No	No	0	6	6
123	R:R:I181	R:R:R185	3.76	No	No	0	7	4
124	R:R:H182	R:R:S184	9.76	No	No	0	5	6
125	R:R:R185	R:R:S184	5.27	No	No	0	4	6
126	R:R:F186	R:R:N187	12.08	No	No	0	4	6
127	R:R:N187	R:R:T190	4.39	No	No	0	6	5
128	R:R:L194	R:R:N187	5.49	No	No	0	3	6
129	R:R:K191	R:R:K195	18.68	No	No	7	6	6
130	R:R:F193	R:R:I197	5.02	No	No	0	4	2
131	R:R:I206	R:R:V241	4.61	No	No	0	6	4
132	R:R:F213	R:R:V212	7.87	No	No	0	4	5
133	R:R:F213	R:R:F234	5.36	No	No	0	4	7
134	R:R:K220	R:R:S219	10.71	No	No	0	3	3
135	R:R:K223	R:R:L228	11.28	No	No	0	3	4
136	R:R:A230	R:R:K223	6.42	No	No	0	3	3
137	R:R:F234	R:R:L229	4.87	No	No	0	7	4
138	L:L:?1	R:R:L229	4.62	Yes	No	0	0	4
139	R:R:D231	R:R:F234	20.3	No	No	0	5	7
140	R:R:D232	R:R:V347	7.3	No	No	0	4	5
141	L:L:?1	R:R:V235	3.98	Yes	No	0	0	6
142	R:R:G238	R:R:I237	3.53	No	No	0	6	4
143	R:R:F244	R:R:S239	3.96	No	No	0	5	6
144	R:R:F340	R:R:S239	3.96	Yes	No	0	7	6
145	R:R:I344	R:R:S239	7.74	Yes	No	0	5	6
146	R:R:F240	R:R:F244	9.65	No	No	0	4	5
147	R:R:F240	R:R:I344	3.77	No	Yes	0	4	5
148	R:R:F243	R:R:F244	7.5	Yes	No	0	8	5
149	R:R:F243	R:R:W336	4.01	Yes	Yes	2	8	8
150	R:R:F243	R:R:F340	22.51	Yes	Yes	2	8	7
151	R:R:F329	R:R:M250	12.44	Yes	Yes	9	8	8
152	R:R:F255	R:R:Y254	6.19	No	Yes	0	1	9
153	R:R:I258	R:R:Y254	14.51	No	Yes	0	5	9
154	R:R:G326	R:R:Y254	5.79	No	Yes	0	6	9
155	R:R:F329	R:R:Y254	9.28	Yes	Yes	0	8	9
156	R:R:C322	R:R:I258	6.55	No	No	0	7	5
157	R:R:K259	R:R:K263	8.62	No	No	0	4	5
158	R:R:E264	R:R:S260	5.75	No	No	10	7	6
159	R:R:Q262	R:R:Q319	3.84	No	No	0	6	5
160	R:R:K320	R:R:S316	7.65	No	No	0	8	6
161	R:R:K320	R:R:N317	5.6	No	No	0	8	6
162	R:R:F383	R:R:K323	3.72	Yes	No	0	7	7
163	R:R:F383	R:R:V324	3.93	Yes	No	0	7	8
164	R:R:I327	R:R:V379	7.68	No	No	11	6	8
165	R:R:F383	R:R:I327	3.77	Yes	No	11	7	6
166	R:R:N376	R:R:V328	7.39	Yes	No	0	9	8
167	R:R:F330	R:R:V334	13.11	No	No	0	5	5
168	R:R:L331	R:R:V375	5.96	No	No	0	6	6
169	R:R:F332	R:R:W336	7.02	Yes	Yes	0	9	8
170	R:R:F332	R:R:S372	3.96	Yes	No	0	9	9
171	R:R:F339	R:R:W336	8.02	Yes	Yes	2	7	8
172	R:R:F340	R:R:W336	6.01	Yes	Yes	2	7	8
173	R:R:G369	R:R:W336	12.67	No	Yes	0	7	8
174	R:R:W336	R:R:Y370	3.86	Yes	Yes	2	8	7
175	L:L:?1	R:R:W336	12.17	Yes	Yes	2	0	8
176	R:R:F365	R:R:P338	7.22	Yes	No	0	5	9
177	R:R:F339	R:R:F340	6.43	Yes	Yes	2	7	7
178	R:R:F339	R:R:N343	4.83	Yes	No	0	7	7
179	R:R:F339	R:R:V366	3.93	Yes	No	0	7	6
180	L:L:?1	R:R:F339	6.51	Yes	Yes	2	0	7
181	L:L:?1	R:R:F340	17.08	Yes	Yes	2	0	7
182	R:R:L362	R:R:T342	5.9	No	No	0	3	5
183	R:R:F365	R:R:T342	6.49	Yes	No	0	5	5
184	R:R:L362	R:R:N343	4.12	No	No	0	3	7
185	R:R:C349	R:R:S352	3.44	No	No	0	3	2
186	R:R:C349	R:R:C353	5.46	No	No	0	3	3
187	R:R:E351	R:R:K350	4.05	No	No	0	5	1
188	R:R:D356	R:R:N354	8.08	No	No	0	2	1
189	R:R:N354	R:R:V357	4.43	No	No	0	1	5
190	R:R:E355	R:R:I358	8.2	No	No	0	3	4
191	R:R:G359	R:R:L362	3.42	No	No	0	2	3
192	R:R:F365	R:R:L361	8.53	Yes	No	0	5	4
193	R:R:F365	R:R:V364	3.93	Yes	No	0	5	4
194	R:R:F365	R:R:I368	3.77	Yes	No	0	5	7
195	R:R:V366	R:R:Y370	5.05	No	Yes	0	6	7
196	R:R:W367	R:R:Y370	5.79	Yes	Yes	2	6	7
197	R:R:N376	R:R:P377	6.52	Yes	Yes	0	9	9
198	R:R:N376	R:R:Y380	8.14	Yes	Yes	0	9	9
199	R:R:F383	R:R:V379	5.24	Yes	No	11	7	8
200	R:R:Y380	R:R:Y387	8.94	Yes	Yes	0	9	8
201	R:R:F391	R:R:T381	3.89	Yes	No	0	6	7
202	R:R:F383	R:R:L382	7.31	Yes	No	0	7	5
203	R:R:N384	R:R:T386	8.77	No	No	5	9	6
204	R:R:N384	R:R:Y387	11.63	No	Yes	5	9	8
205	R:R:F391	R:R:Y387	5.16	Yes	Yes	0	6	8
206	R:R:R393	R:R:S389	9.22	No	No	0	4	4
207	R:R:A390	R:R:Y394	4	No	Yes	0	7	4
208	R:R:Q398	R:R:R393	17.52	No	No	0	4	4
209	R:R:Q396	S:S:T190	5.67	No	No	0	4	5
210	S:S:H70	S:S:L71	3.86	No	No	0	3	3
211	S:S:N75	S:S:Q72	14.52	No	No	0	5	1
212	S:S:N75	S:S:W76	7.91	No	No	0	5	4
213	S:S:L79	S:S:W76	3.42	No	No	0	4	4
214	S:S:M132	S:S:T81	6.02	No	No	0	6	6
215	S:S:T81	S:S:W367	18.19	No	Yes	0	6	6
216	S:S:V84	S:S:W367	4.9	No	Yes	0	7	6
217	S:S:I85	S:S:M128	4.37	Yes	Yes	1	6	8
218	S:S:I85	S:S:P129	6.77	Yes	No	0	6	8
219	S:S:I85	S:S:W367	3.52	Yes	Yes	1	6	6
220	S:S:M128	S:S:T88	4.52	Yes	No	0	8	7
221	S:S:G91	S:S:P377	4.06	No	No	0	8	9
222	S:S:A117	S:S:N92	4.69	No	No	0	9	9
223	S:S:D120	S:S:N92	6.73	No	No	0	9	9
224	S:S:N92	S:S:P377	8.15	No	No	0	9	9
225	S:S:I93	S:S:M97	4.37	No	No	0	3	4
226	S:S:F391	S:S:L94	15.83	Yes	No	0	6	6
227	S:S:P377	S:S:V95	3.53	No	No	0	9	9
228	S:S:V95	S:S:Y380	8.83	No	Yes	0	9	9
229	S:S:I118	S:S:I96	5.89	No	No	0	6	6
230	S:S:M97	S:S:Y394	7.18	No	Yes	0	4	4
231	S:S:M114	S:S:V99	9.13	No	No	0	5	7
232	S:S:V99	S:S:Y387	3.79	No	Yes	0	7	8
233	S:S:L101	S:S:Y394	8.21	No	Yes	3	5	4
234	S:S:L101	S:S:Y399	24.62	No	No	3	5	2
235	S:S:E102	S:S:K104	4.05	Yes	No	0	6	6
236	S:S:E102	S:S:L105	5.3	Yes	Yes	3	6	8
237	S:S:E102	S:S:T386	4.23	Yes	No	3	6	6
238	S:S:E102	S:S:R393	5.82	Yes	Yes	3	6	4
239	S:S:K103	S:S:Q106	9.49	No	No	0	6	7
240	S:S:L105	S:S:N110	6.87	Yes	No	3	8	9
241	S:S:L105	S:S:T386	7.37	Yes	No	3	8	6
242	S:S:L105	S:S:Y387	7.03	Yes	Yes	3	8	8
243	S:S:Q106	S:S:Y111	11.27	No	No	12	7	4
244	S:S:Q106	S:S:R189	5.84	No	No	12	7	4
245	S:S:N107	S:S:N110	10.9	No	No	0	7	9
246	S:S:N110	S:S:Y387	5.81	No	Yes	3	9	8
247	S:S:R189	S:S:Y111	10.29	No	No	12	4	4
248	S:S:F112	S:S:I169	8.79	Yes	No	0	8	9
249	S:S:D172	S:S:F112	4.78	No	Yes	6	9	8
250	S:S:F112	S:S:K195	7.44	Yes	No	6	8	6
251	S:S:F112	S:S:I196	7.54	Yes	No	0	8	8
252	S:S:L113	S:S:Y380	7.03	No	Yes	0	8	9
253	S:S:H165	S:S:S115	6.97	Yes	No	13	8	9
254	S:S:S115	S:S:W200	4.94	No	No	13	9	9
255	S:S:H165	S:S:L116	9	Yes	No	0	8	9
256	S:S:D120	S:S:S162	4.42	No	No	0	9	9
257	S:S:D120	S:S:S373	10.31	No	No	0	9	9
258	S:S:F158	S:S:L122	7.31	No	No	0	7	7
259	S:S:F158	S:S:L123	3.65	No	No	0	7	7
260	S:S:G124	S:S:M128	5.24	No	Yes	0	6	8
261	S:S:F125	S:S:L126	6.09	No	No	0	4	5
262	S:S:D155	S:S:V127	10.22	No	No	0	8	8
263	S:S:M128	S:S:W367	3.49	Yes	Yes	1	8	6
264	S:S:M128	S:S:Y370	9.58	Yes	Yes	1	8	7
265	S:S:V130	S:S:W141	3.68	No	Yes	1	4	7
266	S:S:V130	S:S:W151	12.26	No	Yes	1	4	5
267	S:S:S131	S:S:W367	7.41	No	Yes	0	7	6
268	S:S:L133	S:S:Y137	3.52	No	No	1	4	4
269	S:S:L133	S:S:P142	4.93	No	Yes	1	4	3
270	S:S:T134	S:S:W141	3.64	No	Yes	1	5	7
271	S:S:P142	S:S:T134	3.5	Yes	No	1	3	5
272	S:S:I135	S:S:Y139	9.67	No	Yes	0	5	3
273	S:S:P142	S:S:Y137	6.95	Yes	No	1	3	4
274	S:S:N363	S:S:Y139	16.28	No	Yes	0	4	3
275	S:S:P142	S:S:W141	8.11	Yes	Yes	1	3	7
276	S:S:L143	S:S:W141	11.39	No	Yes	1	5	7
277	S:S:C148	S:S:W141	16.98	No	Yes	1	9	7
278	S:S:W141	S:S:W151	6.56	Yes	Yes	1	7	5
279	S:S:C227	S:S:W141	3.92	Yes	Yes	1	9	7
280	S:S:L143	S:S:P142	9.85	No	Yes	1	5	3
281	S:S:L147	S:S:P144	11.49	No	No	0	5	7
282	S:S:K146	S:S:L215	4.23	No	No	0	1	5
283	S:S:C148	S:S:C227	7.28	No	Yes	1	9	9
284	S:S:I152	S:S:W151	3.52	No	Yes	0	5	5
285	M:M:?1	S:S:W151	3.8	Yes	Yes	1	0	5
286	S:S:I152	S:S:L229	5.71	No	No	0	5	4
287	S:S:L157	S:S:Y153	3.52	Yes	Yes	14	6	6
288	S:S:S207	S:S:Y153	19.08	No	Yes	14	7	6
289	S:S:M208	S:S:Y153	4.79	No	Yes	0	4	6
290	S:S:I210	S:S:Y153	3.63	No	Yes	0	6	6
291	S:S:P211	S:S:Y153	11.13	No	Yes	0	5	6
292	S:S:D155	S:S:Y370	9.2	No	Yes	0	8	7
293	M:M:?1	S:S:D155	17.22	Yes	No	0	0	8
294	S:S:I210	S:S:V156	4.61	No	No	0	6	6
295	M:M:?1	S:S:V156	9.95	Yes	No	0	0	6
296	S:S:F158	S:S:L157	8.53	No	Yes	0	7	6
297	S:S:L157	S:S:S207	7.51	Yes	No	14	6	7
298	M:M:?1	S:S:S159	12.03	Yes	No	0	0	7
299	S:S:S242	S:S:T160	7.99	No	No	0	6	7
300	S:S:A161	S:S:S203	3.42	No	No	0	8	8
301	S:S:F332	S:S:I163	5.02	Yes	No	0	9	8
302	S:S:M164	S:S:S203	7.67	No	No	0	6	8
303	S:S:H165	S:S:V199	4.15	Yes	No	0	8	6
304	S:S:H165	S:S:W200	8.46	Yes	No	13	8	9
305	S:S:L166	S:S:M250	4.24	No	No	1	8	8
306	S:S:F329	S:S:L166	3.65	Yes	No	1	8	8
307	S:S:F332	S:S:L166	6.09	Yes	No	1	9	8
308	S:S:C167	S:S:M250	4.86	No	No	0	6	8
309	S:S:A168	S:S:V199	5.09	No	No	0	7	6
310	S:S:S170	S:S:T253	4.8	No	No	0	9	5
311	S:S:F329	S:S:S170	5.28	Yes	No	0	8	9
312	S:S:D172	S:S:K195	22.12	No	No	6	9	6
313	S:S:E318	S:S:R173	10.47	No	No	0	8	9
314	S:S:C322	S:S:R173	4.18	No	No	0	7	9
315	S:S:L325	S:S:R173	3.64	No	No	0	8	9
316	S:S:L256	S:S:Y174	3.52	No	No	0	5	8
317	S:S:T257	S:S:Y174	7.49	No	No	0	9	8
318	S:S:I177	S:S:S260	4.64	No	No	0	9	6
319	S:S:F193	S:S:I197	5.02	No	No	0	4	2
320	S:S:Q216	S:S:V212	5.73	No	No	0	6	5
321	S:S:F213	S:S:F234	39.65	No	No	0	4	7
322	S:S:C227	S:S:V221	3.42	Yes	No	0	9	3
323	S:S:C227	S:S:F222	8.38	Yes	No	0	9	2
324	S:S:K223	S:S:L228	8.46	No	No	0	3	4
325	M:M:?1	S:S:L229	8.32	Yes	No	0	0	4
326	S:S:D231	S:S:F234	17.91	No	No	0	5	7
327	S:S:D232	S:S:V347	10.22	No	Yes	15	4	5
328	S:S:D232	S:S:K350	13.83	No	No	15	4	1
329	M:M:?1	S:S:V235	3.98	Yes	No	0	0	6
330	S:S:L236	S:S:V347	4.47	No	Yes	0	6	5
331	S:S:F340	S:S:S239	5.28	Yes	No	0	7	6
332	S:S:I344	S:S:S239	4.64	No	No	0	5	6
333	S:S:F240	S:S:F244	11.79	No	No	0	4	5
334	M:M:?1	S:S:S242	6.02	Yes	No	0	0	6
335	S:S:F243	S:S:F244	9.65	No	No	0	8	5
336	S:S:F243	S:S:F340	21.43	No	Yes	0	8	7
337	S:S:I245	S:S:P246	5.08	No	No	0	5	9
338	S:S:F329	S:S:M250	13.68	Yes	No	1	8	8
339	S:S:F255	S:S:Y254	5.16	No	Yes	0	1	9
340	S:S:I258	S:S:Y254	10.88	Yes	Yes	0	5	9
341	S:S:G326	S:S:Y254	7.24	No	Yes	0	6	9
342	S:S:F329	S:S:Y254	6.19	Yes	Yes	0	8	9
343	S:S:I258	S:S:Q262	4.12	Yes	No	0	5	6
344	S:S:C322	S:S:I258	4.91	No	Yes	0	7	5
345	S:S:E264	S:S:K263	4.05	No	No	0	7	5
346	S:S:N317	S:S:Q313	3.96	No	No	0	6	5
347	S:S:Q319	S:S:S316	7.22	Yes	No	0	5	6
348	S:S:K320	S:S:Q319	4.07	No	Yes	0	8	5
349	S:S:K323	S:S:Q319	5.42	No	Yes	0	7	5
350	S:S:K320	S:S:V324	6.07	No	No	0	8	8
351	S:S:K320	S:S:N384	6.99	No	No	0	8	9
352	S:S:I327	S:S:V379	7.68	No	No	0	6	8
353	S:S:F383	S:S:I327	3.77	No	No	0	7	6
354	S:S:F329	S:S:V328	3.93	Yes	No	0	8	8
355	S:S:N376	S:S:V328	5.91	No	No	0	9	8
356	S:S:F330	S:S:V334	11.8	No	No	0	5	5
357	S:S:L331	S:S:V375	5.96	No	No	0	6	6
358	S:S:F332	S:S:W336	9.02	Yes	Yes	1	9	8
359	S:S:F332	S:S:S372	5.28	Yes	No	1	9	9
360	S:S:F339	S:S:W336	7.02	Yes	Yes	1	7	8
361	S:S:G369	S:S:W336	12.67	No	Yes	0	7	8
362	S:S:S372	S:S:W336	3.71	No	Yes	1	9	8
363	M:M:?1	S:S:W336	13.69	Yes	Yes	1	0	8
364	S:S:F365	S:S:P338	8.67	Yes	No	0	5	9
365	S:S:F339	S:S:F340	9.65	Yes	Yes	1	7	7
366	S:S:F339	S:S:N343	7.25	Yes	No	1	7	7
367	S:S:F339	S:S:L362	4.87	Yes	No	1	7	3
368	S:S:F339	S:S:V366	6.55	Yes	No	1	7	6
369	M:M:?1	S:S:F339	8.95	Yes	Yes	1	0	7
370	M:M:?1	S:S:F340	17.08	Yes	Yes	1	0	7
371	S:S:L362	S:S:T342	4.42	No	No	0	3	5
372	S:S:F365	S:S:T342	5.19	Yes	No	0	5	5
373	S:S:L362	S:S:N343	5.49	No	No	1	3	7
374	M:M:?1	S:S:N343	4.58	Yes	No	1	0	7
375	S:S:I344	S:S:I348	7.36	No	No	0	5	4
376	S:S:I348	S:S:M345	4.37	No	No	0	4	4
377	S:S:K350	S:S:V347	6.07	No	Yes	15	1	5
378	S:S:C349	S:S:C353	7.28	No	No	0	3	3
379	S:S:N354	S:S:V357	8.87	No	No	0	1	5
380	S:S:E355	S:S:I358	4.1	No	Yes	0	3	4
381	S:S:F365	S:S:L361	6.09	Yes	No	0	5	4
382	S:S:F365	S:S:I368	3.77	Yes	No	0	5	7
383	S:S:V366	S:S:W367	3.68	No	Yes	1	6	6
384	S:S:V366	S:S:Y370	6.31	No	Yes	1	6	7
385	S:S:W367	S:S:Y370	10.61	Yes	Yes	1	6	7
386	S:S:N376	S:S:Y380	3.49	No	Yes	0	9	9
387	S:S:Y380	S:S:Y387	17.87	Yes	Yes	0	9	8
388	S:S:F391	S:S:T381	6.49	Yes	No	0	6	7
389	S:S:F383	S:S:L382	9.74	No	No	0	7	5
390	S:S:N384	S:S:Y387	5.81	No	Yes	0	9	8
391	S:S:K385	S:S:T386	12.01	No	No	0	5	6
392	S:S:K385	S:S:R388	3.71	No	No	0	5	9
393	S:S:F391	S:S:Y387	5.16	Yes	Yes	0	6	8
394	S:S:A390	S:S:Y394	5.34	No	Yes	0	7	4
395	S:S:R393	S:S:Y394	8.23	Yes	Yes	3	4	4
396	S:S:R393	S:S:Y399	6.17	Yes	No	3	4	2
397	S:S:K400	S:S:R393	9.9	No	Yes	0	3	4
398	S:S:Y394	S:S:Y399	8.94	Yes	No	3	4	2
399	S:S:K400	S:S:Q398	13.56	No	No	0	3	4
400	R:R:A371	R:R:V84	3.39	No	No	0	4	7
401	R:R:I245	R:R:P246	3.39	No	No	0	5	9
402	R:R:A247	R:R:V333	3.39	No	No	0	6	6
403	S:S:A371	S:S:V84	3.39	No	No	0	4	7
404	S:S:I163	S:S:P246	3.39	No	No	0	8	9
405	S:S:A247	S:S:V333	3.39	No	No	0	6	6
406	R:R:E102	R:R:Y394	3.37	No	Yes	0	6	4
407	S:S:L143	S:S:P144	3.28	No	No	0	5	7
408	R:R:C167	R:R:I249	3.27	No	No	0	6	6
409	S:S:C167	S:S:I249	3.27	No	No	0	6	6
410	S:S:C337	S:S:I341	3.27	No	No	0	6	6
411	R:R:N179	R:R:P180	3.26	No	No	0	6	8
412	R:R:A265	R:R:I315	3.25	No	No	0	5	5
413	S:S:A346	S:S:I358	3.25	No	Yes	0	4	4
414	R:R:A82	R:R:M132	3.22	No	No	0	3	6
415	S:S:V235	S:S:V347	3.21	No	Yes	0	6	5
416	R:R:S203	R:R:T160	3.2	No	No	0	8	7
417	R:R:S392	S:S:T190	3.2	No	No	0	3	5
418	S:S:S203	S:S:T160	3.2	No	No	0	8	7
419	S:S:A374	S:S:L87	3.15	No	No	0	6	4
420	R:R:I206	R:R:S242	3.1	No	No	0	6	6
421	S:S:I206	S:S:V241	3.07	No	No	0	6	4
422	S:S:I252	S:S:V251	3.07	No	No	0	5	5
423	S:S:M335	S:S:S372	3.07	No	No	0	8	9
424	S:S:I358	S:S:V357	3.07	Yes	No	0	4	5
425	S:S:K74	S:S:S77	3.06	No	No	0	6	3
426	S:S:K263	S:S:S260	3.06	No	No	0	5	6
427	R:R:A346	R:R:E355	3.02	No	No	0	4	3
428	R:R:M312	R:R:T311	3.01	No	No	0	4	4
429	R:R:L116	R:R:S162	3	No	No	0	9	9
430	S:S:L116	S:S:S162	3	No	No	0	9	9
431	R:R:L87	R:R:V83	2.98	No	No	0	4	4
432	R:R:L157	R:R:V204	2.98	Yes	No	0	6	4
433	R:R:L236	R:R:V347	2.98	No	No	0	6	5
434	S:S:L79	S:S:V83	2.98	No	No	0	4	4
435	S:S:L87	S:S:V83	2.98	No	No	0	4	4
436	S:S:L154	S:S:V127	2.98	No	No	0	5	8
437	S:S:L157	S:S:V204	2.98	Yes	No	0	6	4
438	S:S:L171	S:S:V175	2.98	No	No	0	6	5
439	R:R:L382	R:R:T381	2.95	No	No	0	5	7
440	S:S:I85	S:S:I89	2.94	Yes	No	0	6	5
441	R:R:I93	R:R:M97	2.92	No	No	0	3	4
442	R:R:I93	R:R:M121	2.92	No	No	0	3	7
443	R:R:I368	R:R:M335	2.92	No	No	0	7	8
444	S:S:I93	S:S:M121	2.92	No	No	0	3	7
445	S:S:N107	S:S:T109	2.92	No	No	0	7	8
446	S:S:I202	S:S:M164	2.92	No	No	0	5	6
447	R:R:G138	R:R:Y139	2.9	No	Yes	0	5	3
448	S:S:G138	S:S:Y139	2.9	No	Yes	0	5	3
449	S:S:F213	S:S:P209	2.89	No	No	0	4	7
450	R:R:I169	R:R:L325	2.85	No	No	0	9	8
451	R:R:I344	R:R:L236	2.85	Yes	No	0	5	6
452	R:R:I327	R:R:L331	2.85	No	No	0	6	6
453	S:S:I169	S:S:L113	2.85	No	No	0	9	8
454	S:S:L136	S:S:M132	2.83	No	No	0	5	6
455	S:S:K195	S:S:L171	2.82	No	No	0	6	6
456	R:R:C337	R:R:F243	2.79	No	Yes	0	6	8
457	R:R:A98	R:R:F391	2.77	No	Yes	0	7	6
458	S:S:L79	S:S:L80	2.77	No	No	0	4	4
459	S:S:A98	S:S:F391	2.77	No	Yes	0	7	6
460	S:S:E355	S:S:K223	2.7	No	No	0	3	3
461	S:S:D231	S:S:N233	2.69	No	No	0	5	3
462	S:S:L69	S:S:Q72	2.66	No	No	0	2	1
463	S:S:R140	S:S:S226	2.64	No	No	0	4	4
464	R:R:F255	R:R:V251	2.62	No	No	0	1	5
465	S:S:F243	S:S:V333	2.62	No	No	0	8	6
466	S:S:F383	S:S:V324	2.62	No	No	0	7	8
467	R:R:A119	R:R:W200	2.59	No	No	0	8	9
468	S:S:A119	S:S:W200	2.59	No	No	0	8	9
469	R:R:V175	R:R:Y174	2.52	No	Yes	0	5	8
470	S:S:V99	S:S:Y111	2.52	No	No	0	7	4
471	R:R:K385	R:R:R388	2.48	No	No	0	5	9
472	S:S:F234	S:S:L229	2.44	No	No	0	7	4
473	R:R:M208	R:R:Y153	2.39	No	No	0	4	6
474	S:S:I135	S:S:W367	2.35	No	Yes	0	5	6
475	M:M:?1	S:S:G238	2.28	Yes	No	0	0	6
476	R:R:R140	R:R:Y139	2.06	No	Yes	0	4	3
477	S:S:R140	S:S:Y139	2.06	No	Yes	0	4	3
478	R:R:A90	R:R:G91	1.95	No	No	0	4	8
479	R:R:A149	R:R:G214	1.95	No	No	0	6	7
480	S:S:A149	S:S:G214	1.95	No	No	0	6	7
481	S:S:C337	S:S:P338	1.88	No	No	0	6	9
482	R:R:G205	R:R:V204	1.84	No	No	0	4	4
483	S:S:G214	S:S:V221	1.84	No	No	0	7	3
484	S:S:A108	S:S:A192	1.79	No	No	6	5	7
485	R:R:G124	R:R:I89	1.76	No	No	0	6	5
486	R:R:G359	R:R:I358	1.76	No	No	0	2	4
487	S:S:G238	S:S:I237	1.76	No	No	0	6	4
488	S:S:G359	S:S:I358	1.76	No	Yes	0	2	4
489	S:S:G214	S:S:K146	1.74	No	No	0	7	1
490	R:R:L79	S:S:G205	1.71	No	No	0	4	4
491	R:R:G214	R:R:L215	1.71	No	No	0	7	5
492	S:S:A78	S:S:S77	1.71	No	No	0	6	3
493	R:R:A374	R:R:T88	1.68	No	No	0	6	7
494	R:R:M208	R:R:P209	1.68	No	No	0	4	7
495	S:S:A374	S:S:T88	1.68	No	No	0	6	7
496	S:S:C353	S:S:I358	1.64	No	Yes	0	3	4
497	R:R:A117	R:R:I96	1.62	No	No	0	9	6
498	R:R:A149	R:R:I210	1.62	No	No	0	6	6
499	R:R:C167	R:R:M250	1.62	No	Yes	0	6	8
500	R:R:C349	R:R:M345	1.62	No	No	0	3	4
501	S:S:A117	S:S:I96	1.62	No	No	0	9	6
502	S:S:C349	S:S:M345	1.62	No	No	0	3	4
503	S:S:A82	S:S:M132	1.61	No	No	0	3	6
504	S:S:A230	S:S:K220	1.61	No	No	0	3	3
505	S:S:A230	S:S:K223	1.61	No	No	0	3	3
506	R:R:S188	R:R:T190	1.6	No	No	0	7	5
507	R:R:S314	R:R:T311	1.6	No	No	0	5	4
508	S:S:V333	S:S:V334	1.6	No	No	0	6	5
509	S:S:V375	S:S:V379	1.6	No	No	0	6	8
510	R:R:A78	R:R:L136	1.58	No	No	0	6	5
511	R:R:A374	R:R:L87	1.58	No	No	0	6	4
512	S:S:A78	S:S:L136	1.58	No	No	0	6	5
513	R:R:A108	R:R:N107	1.56	No	No	0	5	7
514	S:S:A360	S:S:N363	1.56	No	No	0	1	4
515	R:R:I135	R:R:S77	1.55	No	No	0	5	3
516	R:R:I315	R:R:S314	1.55	No	No	0	5	5
517	S:S:I315	S:S:S314	1.55	No	No	0	5	5
518	R:R:I237	R:R:V241	1.54	No	No	0	4	4
519	R:R:I358	R:R:V357	1.54	No	No	0	4	5
520	S:S:I237	S:S:V241	1.54	No	No	0	4	4
521	S:S:M114	S:S:S100	1.53	No	No	0	5	1
522	S:S:K146	S:S:S145	1.53	No	No	0	1	3
523	R:R:I202	R:R:T201	1.52	No	No	0	5	4
524	R:R:K220	R:R:V221	1.52	No	No	0	3	3
525	R:R:I252	R:R:T248	1.52	No	No	0	5	3
526	R:R:M250	R:R:V333	1.52	Yes	No	0	8	6
527	S:S:I202	S:S:T201	1.52	No	No	0	5	4
528	S:S:I258	S:S:T257	1.52	Yes	No	0	5	9
529	S:S:M312	S:S:T311	1.51	No	No	0	4	4
530	R:R:G225	R:R:R140	1.5	No	No	0	3	4
531	S:S:G225	S:S:R140	1.5	No	No	0	3	4
532	R:R:L147	R:R:V150	1.49	Yes	No	0	5	4
533	S:S:L126	S:S:V127	1.49	No	No	0	5	8
534	R:R:L171	R:R:T253	1.47	No	No	0	6	5
535	R:R:I196	R:R:I197	1.47	No	No	0	8	2
536	R:R:I344	R:R:I348	1.47	Yes	No	0	5	4
537	S:S:I196	S:S:I197	1.47	No	No	0	8	2
538	S:S:I315	S:S:M312	1.46	No	No	0	5	4
539	S:S:E351	S:S:S352	1.44	No	No	0	5	2
540	R:R:Q106	R:R:V99	1.43	No	No	0	7	7
541	S:S:I86	S:S:L87	1.43	No	No	0	4	4
542	S:S:I395	S:S:L94	1.43	No	No	0	6	6
543	S:S:Q178	S:S:V175	1.43	No	No	0	6	5
544	S:S:I252	S:S:L256	1.43	No	No	0	5	5
545	R:R:K74	R:R:L71	1.41	No	No	0	6	3
546	R:R:N75	S:S:M208	1.4	No	No	0	5	4
547	S:S:A108	S:S:F112	1.39	No	Yes	6	5	8
548	S:S:A192	S:S:F112	1.39	No	Yes	6	7	8
549	R:R:D232	R:R:K350	1.38	No	No	0	4	1
550	R:R:I315	R:R:Q319	1.37	No	No	0	5	5
551	R:R:K320	R:R:Q319	1.36	No	No	0	8	5
552	R:R:D231	R:R:N233	1.35	No	No	0	5	3
553	S:S:E351	S:S:K350	1.35	No	No	0	5	1
554	S:S:D356	S:S:N354	1.35	No	No	0	2	1
555	S:S:L261	S:S:Q319	1.33	No	Yes	0	8	5
556	R:R:N179	R:R:Q178	1.32	No	No	0	6	6
557	R:R:N317	R:R:Q313	1.32	No	No	0	6	5
558	R:R:E318	R:R:N317	1.31	No	No	0	8	6
559	R:R:F193	R:R:T190	1.3	No	No	0	4	5
560	S:S:F244	S:S:T248	1.3	No	No	0	5	3
561	R:R:Q396	R:R:Q398	1.28	No	No	0	4	4
562	S:S:S260	S:S:Y174	1.27	No	No	0	6	8
563	S:S:F255	S:S:K259	1.24	No	No	0	1	4
564	R:R:F330	R:R:L331	1.22	No	No	0	5	6
565	R:R:N75	R:R:W76	1.13	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L105	6.8825	4	5	8
2	R:R:D120	7.2325	4	0	9
3	R:R:V127	4.92	4	0	8
4	R:R:M128	6.0675	4	0	8
5	R:R:Y139	8.0075	4	0	3
6	R:R:W141	7.01714	7	4	7
7	R:R:P142	6.676	5	4	3
8	R:R:L147	4.475	4	4	5
9	R:R:D155	10.4825	4	2	8
10	R:R:L157	4.5175	4	0	6
11	R:R:F158	7.55	5	8	7
12	R:R:H165	10.4525	4	0	8
13	R:R:R173	5.0325	4	0	9
14	R:R:Y174	4.092	5	0	8
15	R:R:F243	9.2025	4	2	8
16	R:R:M250	4.955	4	9	8
17	R:R:Y254	8.9425	4	0	9
18	R:R:F329	8.3	4	9	8
19	R:R:F332	5.8375	4	0	9
20	R:R:W336	7.68	7	2	8
21	R:R:F339	5.944	5	2	7
22	R:R:F340	11.198	5	2	7
23	R:R:I344	3.9575	4	0	5
24	R:R:F365	5.988	5	0	5
25	R:R:W367	6.815	6	2	6
26	R:R:Y370	5.98	7	2	7
27	R:R:N376	6.5225	4	0	9
28	R:R:P377	5.565	4	0	9
29	R:R:Y380	7.5625	4	0	9
30	R:R:F383	4.794	5	11	7
31	R:R:Y387	8.63333	6	5	8
32	R:R:F391	6.334	5	0	6
33	R:R:Y394	5.3925	4	0	4
34	S:S:I85	4.4	4	1	6
35	S:S:E102	4.85	4	3	6
36	S:S:L105	6.6425	4	3	8
37	S:S:F112	5.22167	6	6	8
38	S:S:M128	5.44	5	1	8
39	S:S:Y139	7.7275	4	0	3
40	S:S:W141	7.75429	7	1	7
41	S:S:P142	6.668	5	1	3
42	S:S:W151	6.535	4	1	5
43	S:S:Y153	8.43	5	14	6
44	S:S:L157	5.635	4	14	6
45	S:S:H165	7.145	4	13	8
46	S:S:C227	5.75	4	1	9
47	S:S:Y254	7.3675	4	0	9
48	S:S:I258	5.3575	4	0	5
49	S:S:Q319	4.51	4	0	5
50	S:S:F329	6.546	5	1	8
51	S:S:F332	6.3525	4	1	9
52	S:S:W336	9.222	5	1	8
53	S:S:F339	7.38167	6	1	7
54	S:S:F340	13.36	4	1	7
55	S:S:V347	5.9925	4	15	5
56	S:S:I358	2.764	5	0	4
57	S:S:F365	5.93	4	0	5
58	S:S:W367	6.76875	8	1	6
59	S:S:Y370	8.925	4	1	7
60	S:S:Y380	9.305	4	0	9
61	S:S:Y387	7.57833	6	3	8
62	S:S:F391	7.5625	4	0	6
63	S:S:R393	7.53	4	3	4
64	S:S:Y394	7.58	5	3	4
65	L:L:?1	9.91111	9	2	0
66	M:M:?1	8.99167	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	S:S:I210	S:S:Y153	10.241	3.63	No	Yes	0	6	6
2	S:S:I210	S:S:V156	10.9886	4.61	No	No	0	6	6
3	M:M:?1	S:S:V156	11.7304	9.95	Yes	No	0	0	6
4	M:M:?1	S:S:D155	15.7772	17.22	Yes	No	0	0	8
5	S:S:D155	S:S:Y370	13.1938	9.2	No	Yes	0	8	7
6	S:S:M128	S:S:Y370	14.0193	9.58	Yes	Yes	1	8	7
7	S:S:M128	S:S:T88	16.8884	4.52	Yes	No	0	8	7
8	S:S:A374	S:S:T88	15.3817	1.68	No	No	0	6	7
9	S:S:A374	S:S:L87	13.8692	3.15	No	No	0	6	4
10	S:S:L87	S:S:V83	10.827	2.98	No	No	0	4	4
11	S:S:F339	S:S:V366	25.6083	6.55	Yes	No	1	7	6
12	S:S:V366	S:S:W367	19.0792	3.68	No	Yes	1	6	6
13	M:M:?1	S:S:W336	35.1797	13.69	Yes	Yes	1	0	8
14	S:S:F332	S:S:W336	61.6279	9.02	Yes	Yes	1	9	8
15	S:S:F332	S:S:L166	61.1892	6.09	Yes	No	1	9	8
16	S:S:F329	S:S:L166	59.1658	3.65	Yes	No	1	8	8
17	S:S:F329	S:S:V328	51.9758	3.93	Yes	No	0	8	8
18	S:S:N376	S:S:V328	51.5428	5.91	No	No	0	9	8
19	S:S:N376	S:S:Y380	51.1041	3.49	No	Yes	0	9	9
20	S:S:V95	S:S:Y380	14.2272	8.83	No	Yes	0	9	9
21	S:S:P377	S:S:V95	13.4363	3.53	No	No	0	9	9
22	S:S:N92	S:S:P377	11.8372	8.15	No	No	0	9	9
23	S:S:Y380	S:S:Y387	34.6515	17.87	Yes	Yes	0	9	8
24	S:S:L105	S:S:Y387	14.08	7.03	Yes	Yes	3	8	8
25	S:S:E102	S:S:L105	10.9164	5.3	Yes	Yes	3	6	8
26	S:S:L113	S:S:Y380	11.0175	7.03	No	Yes	0	8	9
27	S:S:I169	S:S:L113	10.215	2.85	No	No	0	9	8
28	M:M:?1	S:S:W151	15.2576	3.8	Yes	Yes	1	0	5
29	S:S:W141	S:S:W151	13.393	6.56	Yes	Yes	1	7	5
30	S:S:F329	S:S:Y254	15.7916	6.19	Yes	Yes	0	8	9
31	S:S:I258	S:S:Y254	12.6396	10.88	Yes	Yes	0	5	9
32	M:M:?1	S:S:F340	14.6226	17.08	Yes	Yes	1	0	7
33	S:S:F340	S:S:S239	18.4962	5.28	Yes	No	0	7	6
34	S:S:I344	S:S:S239	17.4542	4.64	No	No	0	5	6
35	S:S:I344	S:S:I348	16.4064	7.36	No	No	0	5	4
36	S:S:I348	S:S:M345	15.3529	4.37	No	No	0	4	4
37	S:S:C349	S:S:M345	14.2935	1.62	No	No	0	3	4
38	S:S:C349	S:S:C353	13.2285	7.28	No	No	0	3	3
39	S:S:C353	S:S:I358	12.1576	1.64	No	Yes	0	3	4
40	S:S:N384	S:S:Y387	11.029	5.81	No	Yes	0	9	8
41	S:S:K320	S:S:N384	10.215	6.99	No	No	0	8	9
42	R:R:W367	R:R:Y370	15.1508	5.79	Yes	Yes	2	6	7
43	R:R:N92	R:R:P377	15.9128	8.15	No	Yes	0	9	9
44	R:R:D120	R:R:N92	18.0488	13.46	Yes	No	0	9	9
45	R:R:D120	R:R:L116	88.0993	4.07	Yes	No	0	9	9
46	R:R:H165	R:R:L116	89.0345	9	Yes	No	0	8	9
47	R:R:H165	R:R:W200	93.7653	10.58	Yes	No	0	8	9
48	R:R:A161	R:R:W200	94.5504	7.78	No	No	0	8	9
49	R:R:A161	R:R:S203	94.9343	3.42	No	No	0	8	8
50	R:R:L157	R:R:S203	97.4599	4.5	Yes	No	0	6	8
51	R:R:F158	R:R:L157	100	6.09	Yes	Yes	0	7	6
52	R:R:F158	R:R:L123	82.8345	7.31	Yes	No	0	7	7
53	R:R:L123	R:R:Y370	70.4402	3.52	No	Yes	0	7	7
54	R:R:N376	R:R:P377	15.2836	6.52	Yes	Yes	0	9	9
55	R:R:D120	R:R:N376	70.013	4.04	Yes	Yes	0	9	9
56	R:R:F391	R:R:V95	34.9747	5.24	Yes	No	0	6	9
57	R:R:P377	R:R:V95	25.8681	3.53	Yes	No	0	9	9
58	R:R:V95	R:R:Y380	13.0351	3.79	No	Yes	0	9	9
59	R:R:N376	R:R:Y380	55.1595	8.14	Yes	Yes	0	9	9
60	R:R:F391	R:R:Y387	13.6383	5.16	Yes	Yes	0	6	8
61	R:R:Y380	R:R:Y387	42.5256	8.94	Yes	Yes	0	9	8
62	R:R:F158	R:R:L126	11.5803	3.65	Yes	No	8	7	5
63	R:R:F125	R:R:L126	13.7047	4.87	No	No	0	4	5
64	R:R:F125	R:R:M121	12.8301	3.73	No	No	0	4	7
65	R:R:I93	R:R:M121	11.9498	2.92	No	No	0	3	7
66	R:R:I93	R:R:M97	11.0636	2.92	No	No	0	3	4
67	R:R:M97	R:R:Y394	10.1717	5.99	No	Yes	0	4	4
68	R:R:N110	R:R:Y387	23.8101	10.47	No	Yes	5	9	8
69	R:R:N107	R:R:N110	23.1347	4.09	No	No	0	7	9
70	R:R:N107	R:R:T109	21.3335	4.39	No	No	0	7	8
71	R:R:R173	R:R:T109	20.4243	6.47	Yes	No	0	9	8
72	R:R:L123	R:R:V127	19.3592	4.47	No	Yes	0	7	8
73	R:R:D155	R:R:Y370	13.4767	12.64	Yes	Yes	2	8	7
74	R:R:D155	R:R:V127	28.6679	5.84	Yes	Yes	0	8	8
75	R:R:L154	R:R:V127	19.4949	4.47	No	Yes	0	5	8
76	R:R:F158	R:R:L154	16.392	6.09	Yes	No	8	7	5
77	R:R:V127	R:R:W151	26.9851	4.9	Yes	No	0	8	5
78	R:R:W141	R:R:W151	23.8967	10.31	Yes	No	0	7	5
79	L:L:?1	R:R:L229	15.6531	4.62	Yes	No	0	0	4
80	L:L:?1	R:R:D155	32.6079	19.03	Yes	Yes	2	0	8
81	L:L:?1	R:R:W336	12.5213	12.17	Yes	Yes	2	0	8
82	R:R:W336	R:R:Y370	48.1224	3.86	Yes	Yes	2	8	7
83	L:L:?1	R:R:V156	11.1849	7.96	Yes	No	0	0	6
84	R:R:F332	R:R:W336	26.8928	7.02	Yes	Yes	0	9	8
85	L:L:?1	R:R:I163	11.2628	3.81	Yes	No	0	0	8
86	R:R:F332	R:R:L166	26.3213	6.09	Yes	No	0	9	8
87	R:R:F329	R:R:L166	20.5455	4.87	Yes	No	9	8	8
88	R:R:F329	R:R:S170	14.181	6.61	Yes	No	0	8	9
89	R:R:S170	R:R:T253	13.2054	6.4	No	No	0	9	5
90	R:R:E318	R:R:R173	11.9815	4.65	No	Yes	0	8	9
91	R:R:T253	R:R:Y174	11.2368	4.99	No	Yes	0	5	8
92	R:R:F234	R:R:L229	11.2686	4.87	No	No	0	7	4
93	R:R:E318	R:R:N317	11.0146	1.31	No	No	0	8	6
94	R:R:F383	R:R:L382	30.3132	7.31	Yes	No	0	7	5
95	R:R:L382	R:R:T381	33.6528	2.95	No	No	0	5	7
96	R:R:F391	R:R:T381	36.9866	3.89	Yes	No	0	6	7
97	R:R:F383	R:R:I327	16.8827	3.77	Yes	No	11	7	6
98	R:R:I327	R:R:L331	13.5286	2.85	No	No	0	6	6
99	R:R:F339	R:R:W336	11.0406	8.02	Yes	Yes	2	7	8
100	R:R:L362	R:R:N343	20.9958	4.12	No	No	0	3	7
101	R:R:F339	R:R:N343	22.3495	4.83	Yes	No	0	7	7
102	S:S:F339	S:S:W336	28.0387	7.02	Yes	Yes	1	7	8
103	S:S:F339	S:S:F340	12.9802	9.65	Yes	Yes	1	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:D155	S:S:V127	10.22	0	No	No	8	8	1	2
S:S:V130	S:S:W141	3.68	1	No	Yes	4	7	2	2
S:S:V130	S:S:W151	12.26	1	No	Yes	4	5	2	1
S:S:W141	S:S:W151	6.56	1	Yes	Yes	7	5	2	1
S:S:I152	S:S:W151	3.52	0	No	Yes	5	5	2	1
M:M:?1	S:S:W151	3.8	1	Yes	Yes	0	5	0	1
S:S:I152	S:S:L229	5.71	0	No	No	5	4	2	1
S:S:D155	S:S:Y370	9.2	0	No	Yes	8	7	1	2
M:M:?1	S:S:D155	17.22	1	Yes	No	0	8	0	1
S:S:I210	S:S:V156	4.61	0	No	No	6	6	2	1
M:M:?1	S:S:V156	9.95	1	Yes	No	0	6	0	1
M:M:?1	S:S:S159	12.03	1	Yes	No	0	7	0	1
S:S:S242	S:S:T160	7.99	0	No	No	6	7	1	2
M:M:?1	S:S:L229	8.32	1	Yes	No	0	4	0	1
M:M:?1	S:S:V235	3.98	1	Yes	No	0	6	0	1
S:S:F340	S:S:S239	5.28	1	Yes	No	7	6	1	2
M:M:?1	S:S:S242	6.02	1	Yes	No	0	6	0	1
S:S:F243	S:S:F340	21.43	0	No	Yes	8	7	2	1
S:S:F332	S:S:W336	9.02	1	Yes	Yes	9	8	2	1
S:S:F332	S:S:S372	5.28	1	Yes	No	9	9	2	2
S:S:F339	S:S:W336	7.02	1	Yes	Yes	7	8	1	1
S:S:G369	S:S:W336	12.67	0	No	Yes	7	8	2	1
S:S:S372	S:S:W336	3.71	1	No	Yes	9	8	2	1
M:M:?1	S:S:W336	13.69	1	Yes	Yes	0	8	0	1
S:S:F339	S:S:F340	9.65	1	Yes	Yes	7	7	1	1
S:S:F339	S:S:N343	7.25	1	Yes	No	7	7	1	1
S:S:F339	S:S:L362	4.87	1	Yes	No	7	3	1	2
S:S:F339	S:S:V366	6.55	1	Yes	No	7	6	1	2
M:M:?1	S:S:F339	8.95	1	Yes	Yes	0	7	0	1
M:M:?1	S:S:F340	17.08	1	Yes	Yes	0	7	0	1
S:S:L362	S:S:N343	5.49	1	No	No	3	7	2	1
M:M:?1	S:S:N343	4.58	1	Yes	No	0	7	0	1
S:S:V366	S:S:Y370	6.31	1	No	Yes	6	7	2	2
S:S:V235	S:S:V347	3.21	0	No	Yes	6	5	1	2
S:S:F234	S:S:L229	2.44	0	No	No	7	4	2	1
M:M:?1	S:S:G238	2.28	1	Yes	No	0	6	0	1
S:S:G238	S:S:I237	1.76	0	No	No	6	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D155	R:R:V127	5.84	2	Yes	Yes	8	8	1	2
R:R:I152	R:R:I210	4.42	0	No	No	5	6	2	2
R:R:I152	R:R:L229	8.56	0	No	No	5	4	2	1
R:R:D155	R:R:S159	4.42	2	Yes	No	8	7	1	1
R:R:D155	R:R:Y370	12.64	2	Yes	Yes	8	7	1	2
L:L:?1	R:R:D155	19.03	2	Yes	Yes	0	8	0	1
R:R:I210	R:R:V156	4.61	0	No	No	6	6	2	1
L:L:?1	R:R:V156	7.96	2	Yes	No	0	6	0	1
L:L:?1	R:R:S159	14.04	2	Yes	No	0	7	0	1
R:R:I163	R:R:P246	5.08	0	No	No	8	9	1	2
R:R:F332	R:R:I163	6.28	0	Yes	No	9	8	2	1
L:L:?1	R:R:I163	3.81	2	Yes	No	0	8	0	1
R:R:F234	R:R:L229	4.87	0	No	No	7	4	2	1
L:L:?1	R:R:L229	4.62	2	Yes	No	0	4	0	1
L:L:?1	R:R:V235	3.98	2	Yes	No	0	6	0	1
R:R:F340	R:R:S239	3.96	2	Yes	No	7	6	1	2
R:R:F243	R:R:W336	4.01	2	Yes	Yes	8	8	2	1
R:R:F243	R:R:F340	22.51	2	Yes	Yes	8	7	2	1
R:R:F332	R:R:W336	7.02	0	Yes	Yes	9	8	2	1
R:R:F339	R:R:W336	8.02	2	Yes	Yes	7	8	1	1
R:R:F340	R:R:W336	6.01	2	Yes	Yes	7	8	1	1
R:R:G369	R:R:W336	12.67	0	No	Yes	7	8	2	1
R:R:W336	R:R:Y370	3.86	2	Yes	Yes	8	7	1	2
L:L:?1	R:R:W336	12.17	2	Yes	Yes	0	8	0	1
R:R:F339	R:R:F340	6.43	2	Yes	Yes	7	7	1	1
R:R:F339	R:R:N343	4.83	2	Yes	No	7	7	1	2
R:R:F339	R:R:V366	3.93	2	Yes	No	7	6	1	2
L:L:?1	R:R:F339	6.51	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:F340	17.08	2	Yes	Yes	0	7	0	1
R:R:V366	R:R:Y370	5.05	0	No	Yes	6	7	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6WH4_poly
Class	A
SubFamily	Amine
Type	5-Hydroxytryptamine
SubType	5-HT2A
Species	Homo sapiens
Ligand	Methiothepin
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.4
Date	2020-09-23
D.O.I.	10.1016/j.cell.2020.08.024

Net Summary
I_min	3.42
Number of Linked Nodes	525
Number of Links	565
Number of Hubs	66
Number of Links mediated by Hubs	268
Number of Communities	15
Number of Nodes involved in Communities	88
Number of Links involved in Communities	115

Path Summary
Number Of Nodes in MetaPath	104
Number Of Links MetaPath	103
Number of Shortest Paths	98194
Length Of Smallest Path	3
Average Path Length	14.8242
Length of Longest Path	36
Minimum Path Strength	1.265
Average Path Strength	6.29656
Maximum Path Strength	28.78
Minimum Path Correlation	0.71
Average Path Correlation	0.969826
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	6.66667
Average % Of Corr. Nodes	66.4174
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.8661
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	89F
PDB Residues	L:L:?1 M:M:?1
Environment Details	Open EMBL-EBI Page
Code	89F
Name	1-methyl-4-[(5~{S})-3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine
Synonyms	Methiothepin; Metitepine
Identifier	1-methyl-4-[(5~{S})-3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine
Formula	C20 H24 N2 S2
Molecular Weight	356.548
SMILES	CN1CCN(CC1)[C@H]2Cc3ccccc3Sc4c2cc(cc4)SC
PubChem	7059581
Formal Charge	0
Total Atoms	48
Total Chiral Atoms	1
Total Bonds	51
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P28223
Sequence	>6WH4_poly_Chain_R L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E K K L Q N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G Y R W P L P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N P I H H S R F N S R T K A F L K I I A V W T I S V G I S M P I P V F G L S K V F K E G S C L L A D D N F V L I G S F V S F F I P A T I M V I T Y F L T I K S L Q K E A T M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C K E S C N E D V I G A L L N V F V W I G Y A S S A V N P L V Y T L F N K T Y R S A F S R Y I Q C Q Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6A93	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Risperidone	-	-	3	2019-02-13	10.1038/s41594-018-0180-z
	6A94	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Zotepine	-	-	2.9	2019-02-13	10.1038/s41594-018-0180-z
	6WGT	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.4	2020-09-23	10.1016/j.cell.2020.08.024
	6WH4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	10.1016/j.cell.2020.08.024
	6WHA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-	chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2	3.36	2020-09-23	10.1016/j.cell.2020.08.024
	7RAN	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-	chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2	3.45	2022-07-06	10.1038/s41586-022-05258-z
	7VOD	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Cariprazine	-	-	3.3	2021-12-22	10.1038/s41593-021-00971-w
	7VOE	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Aripiprazole	-	-	2.9	2021-12-22	10.1038/s41593-021-00971-w
	7WC4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	-	3.2	2022-01-26	10.1126/science.abl8615
	7WC5	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	-	3.2	2022-01-26	10.1126/science.abl8615
	7WC6	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	2.6	2022-01-26	10.1126/science.abl8615
	7WC7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	-	2.6	2022-01-26	10.1126/science.abl8615
	7WC8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lumateperone	-	-	2.45	2022-01-26	10.1126/science.abl8615
	7WC9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 162421364	-	-	2.5	2022-01-26	10.1126/science.abl8615
	8JT8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	(R)-IHCH-7179	-	-	2.7	2024-02-28	To be published
	6WGT (Dimer)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.4	2020-09-23	10.1016/j.cell.2020.08.024
	6WH4 (Dimer)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	10.1016/j.cell.2020.08.024

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6WH4_poly.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.