psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D155	5.19	Yes	Yes	1	0	8
2	L:L:?1	R:R:V156	8.95	Yes	No	0	0	6
3	L:L:?1	R:R:S159	9.02	Yes	No	0	0	7
4	L:L:?1	R:R:S242	3.28	Yes	No	1	0	6
5	L:L:?1	R:R:F339	9.98	Yes	Yes	1	0	7
6	L:L:?1	R:R:F340	8.65	Yes	Yes	1	0	7
7	R:R:M132	R:R:T81	4.52	No	No	0	6	6
8	R:R:T81	R:R:W367	21.83	No	Yes	0	6	6
9	R:R:I86	R:R:V83	3.07	No	No	0	4	4
10	R:R:L371	R:R:V84	4.47	No	No	0	4	7
11	R:R:I85	R:R:M128	5.83	Yes	Yes	0	6	8
12	R:R:I85	R:R:P129	5.08	Yes	No	0	6	8
13	R:R:I85	R:R:M132	4.37	Yes	No	0	6	6
14	R:R:M128	R:R:T88	4.52	Yes	No	0	8	7
15	R:R:S373	R:R:T88	3.2	No	No	0	9	7
16	R:R:F125	R:R:I89	6.28	No	No	0	4	5
17	R:R:I96	R:R:N92	7.08	Yes	Yes	4	6	9
18	R:R:A117	R:R:N92	4.69	No	Yes	4	9	9
19	R:R:M121	R:R:N92	14.02	No	Yes	0	7	9
20	R:R:N92	R:R:P377	3.26	Yes	No	0	9	9
21	R:R:F391	R:R:L94	6.09	No	No	0	6	6
22	R:R:T381	R:R:V95	4.76	Yes	No	0	7	9
23	R:R:A117	R:R:I96	3.25	No	Yes	4	9	6
24	R:R:I118	R:R:I96	2.94	No	Yes	0	6	6
25	R:R:M97	R:R:Y394	9.58	No	No	0	4	4
26	R:R:N110	R:R:V99	4.43	Yes	No	3	9	7
27	R:R:M114	R:R:V99	7.61	No	No	0	5	7
28	R:R:V99	R:R:Y387	3.79	No	Yes	3	7	8
29	R:R:L101	R:R:Y394	3.52	No	No	0	5	4
30	R:R:E102	R:R:K104	4.05	No	No	0	6	6
31	R:R:E102	R:R:L105	9.28	No	Yes	0	6	8
32	R:R:K103	R:R:Q106	13.56	No	No	0	6	7
33	R:R:L105	R:R:N110	4.12	Yes	Yes	3	8	9
34	R:R:L105	R:R:T386	4.42	Yes	No	0	8	6
35	R:R:L105	R:R:Y387	4.69	Yes	Yes	3	8	8
36	R:R:Q106	R:R:Y111	4.51	No	No	0	7	4
37	R:R:N110	R:R:Y387	9.3	Yes	Yes	3	9	8
38	R:R:R189	R:R:Y111	4.12	No	No	0	4	4
39	R:R:F112	R:R:H165	7.92	Yes	Yes	2	8	8
40	R:R:A168	R:R:F112	4.16	No	Yes	2	7	8
41	R:R:F112	R:R:I169	5.02	Yes	No	0	8	9
42	R:R:F112	R:R:K195	28.54	Yes	Yes	2	8	6
43	R:R:F112	R:R:I196	5.02	Yes	No	0	8	8
44	R:R:F112	R:R:V199	3.93	Yes	No	2	8	6
45	R:R:L113	R:R:T381	2.95	No	Yes	0	8	7
46	R:R:I118	R:R:M114	4.37	No	No	0	6	5
47	R:R:H165	R:R:S115	6.97	Yes	No	2	8	9
48	R:R:I196	R:R:S115	7.74	No	No	0	8	9
49	R:R:S115	R:R:W200	3.71	No	Yes	2	9	9
50	R:R:H165	R:R:L116	11.57	Yes	No	0	8	9
51	R:R:L116	R:R:N376	4.12	No	Yes	0	9	9
52	R:R:D120	R:R:S373	8.83	No	No	0	9	9
53	R:R:D120	R:R:P377	4.83	No	No	0	9	9
54	R:R:F158	R:R:L122	7.31	No	No	0	7	7
55	R:R:L123	R:R:V127	2.98	No	Yes	0	7	8
56	R:R:F158	R:R:L123	8.53	No	No	0	7	7
57	R:R:L123	R:R:S373	6.01	No	No	0	7	9
58	R:R:G124	R:R:M128	6.99	No	Yes	0	6	8
59	R:R:V127	R:R:W151	9.81	Yes	Yes	1	8	5
60	R:R:D155	R:R:V127	7.3	Yes	Yes	1	8	8
61	R:R:V127	R:R:Y370	5.05	Yes	Yes	1	8	7
62	R:R:M128	R:R:Y370	8.38	Yes	Yes	0	8	7
63	R:R:V130	R:R:W141	3.68	No	Yes	0	4	7
64	R:R:V130	R:R:W151	13.48	No	Yes	0	4	5
65	R:R:S131	R:R:W151	6.18	No	Yes	1	7	5
66	R:R:S131	R:R:W367	3.71	No	Yes	1	7	6
67	R:R:S131	R:R:Y370	5.09	No	Yes	1	7	7
68	R:R:T134	R:R:W141	6.06	No	Yes	0	5	7
69	R:R:P142	R:R:Y137	13.91	No	No	0	3	4
70	R:R:S226	R:R:Y139	8.9	No	No	0	4	3
71	R:R:N363	R:R:Y139	16.28	No	No	0	4	3
72	R:R:P142	R:R:W141	4.05	No	Yes	0	3	7
73	R:R:L143	R:R:W141	14.81	Yes	Yes	0	5	7
74	R:R:C148	R:R:W141	3.92	Yes	Yes	1	9	7
75	R:R:C227	R:R:W141	9.14	Yes	Yes	1	9	7
76	R:R:L143	R:R:P144	3.28	Yes	No	0	5	7
77	R:R:F222	R:R:S145	3.96	Yes	No	0	2	3
78	R:R:C148	R:R:C227	7.28	Yes	Yes	1	9	9
79	R:R:A149	R:R:L215	6.3	No	No	0	6	5
80	R:R:I152	R:R:W151	3.52	Yes	Yes	1	5	5
81	R:R:D155	R:R:W151	3.35	Yes	Yes	1	8	5
82	R:R:C227	R:R:W151	5.22	Yes	Yes	1	9	5
83	R:R:I152	R:R:I210	4.42	Yes	Yes	0	5	6
84	R:R:C227	R:R:I152	3.27	Yes	Yes	1	9	5
85	R:R:I152	R:R:L229	7.14	Yes	No	0	5	4
86	R:R:L157	R:R:Y153	3.52	Yes	No	0	6	6
87	R:R:P211	R:R:Y153	5.56	No	No	0	5	6
88	R:R:F158	R:R:L154	3.65	No	No	0	7	5
89	R:R:D155	R:R:Y370	10.34	Yes	Yes	1	8	7
90	R:R:S207	R:R:V156	6.46	No	No	0	7	6
91	R:R:I210	R:R:V156	4.61	Yes	No	0	6	6
92	R:R:L157	R:R:W200	3.42	Yes	Yes	0	6	9
93	R:R:L157	R:R:S203	4.5	Yes	No	0	6	8
94	R:R:L157	R:R:S207	4.5	Yes	No	0	6	7
95	R:R:S159	R:R:W336	6.18	No	Yes	0	7	8
96	R:R:S203	R:R:T160	3.2	No	No	0	8	7
97	R:R:I206	R:R:T160	7.6	Yes	No	1	6	7
98	R:R:S242	R:R:T160	6.4	No	No	1	6	7
99	R:R:A161	R:R:W200	5.19	No	Yes	0	8	9
100	R:R:A161	R:R:S203	3.42	No	No	0	8	8
101	R:R:F332	R:R:I163	6.28	Yes	No	0	9	8
102	R:R:M164	R:R:V199	3.04	No	No	0	6	6
103	R:R:I202	R:R:M164	10.2	No	No	0	5	6
104	R:R:H165	R:R:V199	4.15	Yes	No	2	8	6
105	R:R:H165	R:R:W200	5.29	Yes	Yes	2	8	9
106	R:R:L166	R:R:Y380	10.55	No	No	0	8	9
107	R:R:C167	R:R:P246	3.77	No	No	0	6	9
108	R:R:C167	R:R:I249	3.27	No	No	0	6	6
109	R:R:A168	R:R:K195	6.42	No	Yes	2	7	6
110	R:R:I169	R:R:R173	5.01	No	No	0	9	9
111	R:R:S170	R:R:T253	4.8	No	No	0	9	5
112	R:R:L171	R:R:T253	4.42	No	No	0	6	5
113	R:R:D172	R:R:K195	13.83	No	Yes	0	9	6
114	R:R:L325	R:R:R173	8.5	No	No	0	8	9
115	R:R:Q178	R:R:Y174	9.02	No	Yes	0	6	8
116	R:R:T253	R:R:Y174	3.75	No	Yes	0	5	8
117	R:R:L256	R:R:Y174	5.86	No	Yes	0	5	8
118	R:R:T257	R:R:Y174	3.75	No	Yes	0	9	8
119	R:R:A176	R:R:H183	8.78	No	Yes	0	8	7
120	R:R:I177	R:R:T257	6.08	No	No	0	9	9
121	R:R:I177	R:R:S260	3.1	No	No	0	9	6
122	R:R:I177	R:R:L261	8.56	No	Yes	0	9	8
123	R:R:N179	R:R:Q178	9.24	No	No	0	6	6
124	R:R:Q178	R:R:S260	4.33	No	No	0	6	6
125	R:R:H182	R:R:R185	6.77	No	No	0	5	4
126	R:R:S188	R:R:T190	4.8	No	No	0	7	5
127	R:R:K191	R:R:L194	5.64	No	No	0	6	3
128	R:R:K191	R:R:K195	5.75	No	Yes	0	6	6
129	R:R:I206	R:R:S207	3.1	Yes	No	0	6	7
130	R:R:I206	R:R:V241	3.07	Yes	No	0	6	4
131	R:R:I206	R:R:S242	3.1	Yes	No	1	6	6
132	R:R:M208	R:R:P209	3.35	No	No	0	4	7
133	R:R:F213	R:R:P209	4.33	No	No	0	4	7
134	R:R:I210	R:R:P211	3.39	Yes	No	0	6	5
135	R:R:F234	R:R:I210	5.02	No	Yes	0	7	6
136	R:R:F213	R:R:V212	3.93	No	No	0	4	5
137	R:R:G214	R:R:K220	3.49	No	No	0	7	3
138	R:R:D231	R:R:K220	6.91	No	No	0	5	3
139	R:R:F222	R:R:G225	3.01	Yes	No	0	2	3
140	R:R:A230	R:R:K223	6.42	No	No	0	3	3
141	R:R:L229	R:R:V235	2.98	No	No	0	4	6
142	R:R:D231	R:R:N233	5.39	No	No	0	5	3
143	R:R:D231	R:R:F234	3.58	No	No	0	5	7
144	R:R:D232	R:R:V347	14.61	No	No	0	4	5
145	R:R:N343	R:R:V235	5.91	No	No	0	7	6
146	R:R:V235	R:R:V347	3.21	No	No	0	6	5
147	R:R:L236	R:R:V347	2.98	No	No	0	6	5
148	R:R:F340	R:R:S239	5.28	Yes	No	0	7	6
149	R:R:N343	R:R:S239	2.98	No	No	0	7	6
150	R:R:F240	R:R:I245	7.54	No	No	0	4	5
151	R:R:F243	R:R:F244	9.65	Yes	No	1	8	5
152	R:R:F243	R:R:F332	5.36	Yes	Yes	1	8	9
153	R:R:C337	R:R:F243	5.59	No	Yes	0	6	8
154	R:R:F243	R:R:F340	25.72	Yes	Yes	1	8	7
155	R:R:I245	R:R:P246	3.39	No	No	0	5	9
156	R:R:F329	R:R:M250	3.73	Yes	No	0	8	8
157	R:R:F332	R:R:M250	7.46	Yes	No	0	9	8
158	R:R:I258	R:R:Y254	3.63	No	No	0	5	9
159	R:R:G326	R:R:Y254	4.35	No	No	0	6	9
160	R:R:F329	R:R:Y254	18.57	Yes	No	0	8	9
161	R:R:K263	R:R:S260	3.06	No	No	0	5	6
162	R:R:E318	R:R:L261	6.63	No	Yes	0	8	8
163	R:R:C322	R:R:L261	4.76	No	Yes	0	7	8
164	R:R:C322	R:R:Q319	3.05	No	No	0	7	5
165	R:R:F383	R:R:V324	9.18	No	No	0	7	8
166	R:R:V328	R:R:Y380	6.31	No	No	0	8	9
167	R:R:F329	R:R:F330	5.36	Yes	No	0	8	5
168	R:R:F329	R:R:V333	3.93	Yes	No	0	8	6
169	R:R:L331	R:R:V375	4.47	No	Yes	0	6	6
170	R:R:F332	R:R:W336	3.01	Yes	Yes	0	9	8
171	R:R:L371	R:R:M335	4.24	No	No	0	4	8
172	R:R:M335	R:R:S372	6.13	No	No	0	8	9
173	R:R:M335	R:R:V375	3.04	No	Yes	0	8	6
174	R:R:G369	R:R:W336	5.63	No	Yes	0	7	8
175	R:R:S372	R:R:W336	8.65	No	Yes	0	9	8
176	R:R:F365	R:R:P338	4.33	No	No	0	5	9
177	R:R:F339	R:R:F340	7.5	Yes	Yes	1	7	7
178	R:R:F339	R:R:N343	7.25	Yes	No	0	7	7
179	R:R:F339	R:R:V366	3.93	Yes	No	0	7	6
180	R:R:L362	R:R:T342	4.42	No	No	0	3	5
181	R:R:F365	R:R:T342	6.49	No	No	0	5	5
182	R:R:I358	R:R:N354	4.25	Yes	No	0	4	1
183	R:R:F365	R:R:L361	12.18	No	No	0	5	4
184	R:R:V366	R:R:Y370	6.31	No	Yes	0	6	7
185	R:R:W367	R:R:Y370	6.75	Yes	Yes	1	6	7
186	R:R:N376	R:R:S372	5.96	Yes	No	0	9	9
187	R:R:N376	R:R:V375	2.96	Yes	Yes	0	9	6
188	R:R:V375	R:R:V379	3.21	Yes	No	0	6	8
189	R:R:N376	R:R:Y380	4.65	Yes	No	0	9	9
190	R:R:T381	R:R:Y387	19.97	Yes	Yes	0	7	8
191	R:R:N384	R:R:T386	5.85	No	No	0	9	6
192	R:R:N384	R:R:Y387	5.81	No	Yes	0	9	8
193	R:R:K385	R:R:T386	9.01	No	No	0	5	6
194	R:R:I348	R:R:M345	2.92	No	No	0	4	4
195	R:R:I327	R:R:K323	2.91	No	No	0	6	7
196	R:R:I237	R:R:L236	2.85	No	No	0	4	6
197	R:R:I344	R:R:L236	2.85	No	No	0	5	6
198	R:R:I358	R:R:L362	2.85	Yes	No	0	4	3
199	R:R:C148	R:R:F222	2.79	Yes	Yes	0	9	2
200	R:R:L126	R:R:L154	2.77	No	No	0	5	5
201	R:R:L133	R:R:L143	2.77	No	Yes	0	4	5
202	R:R:L378	R:R:L382	2.77	No	No	0	6	5
203	R:R:N107	R:R:N110	2.72	No	Yes	0	7	9
204	R:R:A98	R:R:Y387	2.67	No	Yes	0	7	8
205	R:R:F186	R:R:S188	2.64	No	No	0	4	7
206	R:R:F240	R:R:V241	2.62	No	No	0	4	4
207	R:R:F329	R:R:V251	2.62	Yes	No	0	8	5
208	R:R:A119	R:R:W200	2.59	No	Yes	0	8	9
209	R:R:F244	R:R:I341	2.51	No	No	0	5	6
210	R:R:F383	R:R:K320	2.48	No	No	0	7	8
211	R:R:F243	R:R:L247	2.44	Yes	No	1	8	6
212	R:R:F244	R:R:L247	2.44	No	No	1	5	6
213	R:R:F332	R:R:L247	2.44	Yes	No	1	9	6
214	R:R:F339	R:R:L362	2.44	Yes	No	0	7	3
215	R:R:D218	R:R:F222	2.39	No	Yes	0	3	2
216	R:R:I135	R:R:W367	2.35	No	Yes	0	5	6
217	R:R:G91	R:R:P377	2.03	No	No	0	8	9
218	R:R:A90	R:R:G91	1.95	No	No	0	4	8
219	R:R:G205	R:R:V204	1.84	No	No	0	4	4
220	R:R:G238	R:R:V241	1.84	No	No	0	6	4
221	R:R:A390	R:R:A98	1.79	No	No	0	7	7
222	R:R:A108	R:R:A192	1.79	No	No	0	5	7
223	R:R:P211	R:R:V212	1.77	No	No	0	5	5
224	R:R:G359	R:R:I358	1.76	No	Yes	0	2	4
225	R:R:G205	R:R:M208	1.75	No	No	0	4	4
226	R:R:C148	R:R:V221	1.71	Yes	No	0	9	3
227	R:R:A149	R:R:V221	1.7	No	No	0	6	3
228	R:R:A374	R:R:T88	1.68	No	No	0	6	7
229	R:R:C322	R:R:I258	1.64	No	No	0	7	5
230	R:R:C349	R:R:I348	1.64	No	No	0	3	4
231	R:R:N179	R:R:P180	1.63	No	No	0	6	8
232	R:R:S389	R:R:S392	1.63	No	No	0	4	3
233	R:R:A346	R:R:I358	1.62	No	Yes	0	4	4
234	R:R:A82	R:R:M132	1.61	No	No	0	3	6
235	R:R:A374	R:R:L87	1.58	No	No	0	6	4
236	R:R:A321	R:R:L261	1.58	No	Yes	0	8	8
237	R:R:I96	R:R:S100	1.55	Yes	No	0	6	1
238	R:R:I327	R:R:V379	1.54	No	No	0	6	8
239	R:R:I197	R:R:T201	1.52	No	No	0	2	4
240	R:R:I252	R:R:T248	1.52	No	No	0	5	3
241	R:R:L116	R:R:S162	1.5	No	No	0	9	9
242	R:R:L154	R:R:V150	1.49	No	No	0	5	4
243	R:R:I85	R:R:I89	1.47	Yes	No	0	6	5
244	R:R:D218	R:R:S219	1.47	No	No	0	3	3
245	R:R:L382	R:R:T381	1.47	No	Yes	0	5	7
246	R:R:I93	R:R:M97	1.46	No	No	0	3	4
247	R:R:I93	R:R:M121	1.46	No	No	0	3	7
248	R:R:N107	R:R:T109	1.46	No	No	0	7	8
249	R:R:I344	R:R:M345	1.46	No	No	0	5	4
250	R:R:G138	R:R:Y139	1.45	No	No	0	5	3
251	R:R:I93	R:R:L94	1.43	No	No	0	3	6
252	R:R:I252	R:R:L256	1.43	No	No	0	5	5
253	R:R:I368	R:R:L371	1.43	No	No	0	7	4
254	R:R:I135	R:R:N363	1.42	No	No	0	5	4
255	R:R:H183	R:R:S184	1.39	Yes	No	0	7	6
256	R:R:L143	R:R:L147	1.38	Yes	No	0	5	5
257	R:R:H183	R:R:V175	1.38	Yes	No	0	7	5
258	R:R:E224	R:R:K223	1.35	No	No	0	2	3
259	R:R:H182	R:R:I181	1.33	No	No	0	5	7
260	R:R:F383	R:R:V379	1.31	No	No	0	7	8
261	R:R:H182	R:R:N179	1.28	No	No	0	5	6
262	R:R:H183	R:R:N187	1.28	Yes	No	0	7	6
263	R:R:V175	R:R:Y174	1.26	No	Yes	0	5	8
264	R:R:L382	R:R:R388	1.21	No	No	0	5	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.51167	6	1	0
2	R:R:I85	4.1875	4	0	6
3	R:R:N92	7.2625	4	4	9
4	R:R:I96	3.705	4	4	6
5	R:R:L105	5.6275	4	3	8
6	R:R:N110	5.1425	4	3	9
7	R:R:F112	9.09833	6	2	8
8	R:R:V127	6.285	4	1	8
9	R:R:M128	6.43	4	0	8
10	R:R:W141	6.94333	6	1	7
11	R:R:L143	5.56	4	0	5
12	R:R:C148	3.925	4	1	9
13	R:R:W151	6.92667	6	1	5
14	R:R:I152	4.5875	4	1	5
15	R:R:D155	6.545	4	1	8
16	R:R:L157	3.985	4	0	6
17	R:R:H165	7.18	5	2	8
18	R:R:Y174	4.728	5	0	8
19	R:R:H183	3.2075	4	0	7
20	R:R:K195	13.635	4	2	6
21	R:R:W200	4.04	5	2	9
22	R:R:I206	4.2175	4	1	6
23	R:R:I210	4.36	4	0	6
24	R:R:F222	3.0375	4	0	2
25	R:R:C227	6.2275	4	1	9
26	R:R:F243	9.752	5	1	8
27	R:R:L261	5.3825	4	0	8
28	R:R:F329	6.842	5	0	8
29	R:R:F332	4.91	5	1	9
30	R:R:W336	5.8675	4	0	8
31	R:R:F339	6.22	5	1	7
32	R:R:F340	11.7875	4	1	7
33	R:R:I358	2.62	4	0	4
34	R:R:W367	8.66	4	1	6
35	R:R:Y370	6.98667	6	1	7
36	R:R:V375	3.42	4	0	6
37	R:R:N376	4.4225	4	0	9
38	R:R:T381	7.2875	4	0	7
39	R:R:Y387	7.705	6	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D155	100	5.19	Yes	Yes	1	0	8
2	R:R:D155	R:R:Y370	24.6103	10.34	Yes	Yes	1	8	7
3	R:R:M128	R:R:Y370	30.6811	8.38	Yes	Yes	0	8	7
4	R:R:I85	R:R:M128	15.1146	5.83	Yes	Yes	0	6	8
5	R:R:W367	R:R:Y370	16.9221	6.75	Yes	Yes	1	6	7
6	L:L:?1	R:R:S159	61.4473	9.02	Yes	No	0	0	7
7	R:R:S159	R:R:W336	60.9168	6.18	No	Yes	0	7	8
8	R:R:S372	R:R:W336	39.5743	8.65	No	Yes	0	9	8
9	R:R:M335	R:R:S372	16.1624	6.13	No	No	0	8	9
10	R:R:M128	R:R:T88	16.2279	4.52	Yes	No	0	8	7
11	R:R:D155	R:R:V127	51.611	7.3	Yes	Yes	1	8	8
12	R:R:L123	R:R:V127	76.4898	2.98	No	Yes	0	7	8
13	R:R:L123	R:R:S373	69.1421	6.01	No	No	0	7	9
14	R:R:D120	R:R:S373	75.7105	8.83	No	No	0	9	9
15	R:R:D120	R:R:P377	74.2043	4.83	No	No	0	9	9
16	R:R:N92	R:R:P377	69.6071	3.26	Yes	No	0	9	9
17	R:R:I96	R:R:N92	55.3307	7.08	Yes	Yes	4	6	9
18	R:R:M121	R:R:N92	13.6411	14.02	No	Yes	0	7	9
19	R:R:I93	R:R:M121	11.6634	1.46	No	No	0	3	7
20	R:R:I118	R:R:I96	52.148	2.94	No	Yes	0	6	6
21	R:R:I118	R:R:M114	50.4519	4.37	No	No	0	6	5
22	R:R:M114	R:R:V99	48.7164	7.61	No	No	0	5	7
23	R:R:V99	R:R:Y387	32.0105	3.79	No	Yes	3	7	8
24	R:R:T381	R:R:Y387	11.8795	19.97	Yes	Yes	0	7	8
25	R:R:N110	R:R:V99	14.9509	4.43	Yes	No	3	9	7
26	L:L:?1	R:R:V156	27.5115	8.95	Yes	No	0	0	6
27	R:R:S207	R:R:V156	21.5455	6.46	No	No	0	7	6
28	R:R:L157	R:R:S207	20.6483	4.5	Yes	No	0	6	7
29	R:R:L157	R:R:W200	24.7086	3.42	Yes	Yes	0	6	9
30	R:R:H165	R:R:W200	21.0544	5.29	Yes	Yes	2	8	9
31	R:R:F112	R:R:H165	15.9528	7.92	Yes	Yes	2	8	8
32	R:R:N376	R:R:S372	23.89	5.96	Yes	No	0	9	9
33	R:R:L116	R:R:N376	12.6457	4.12	No	Yes	0	9	9
34	R:R:D155	R:R:W151	29.5612	3.35	Yes	Yes	1	8	5
35	R:R:C227	R:R:W151	27.3346	5.22	Yes	Yes	1	9	5
36	R:R:C227	R:R:W141	16.6077	9.14	Yes	Yes	1	9	7
37	R:R:V130	R:R:W151	13.89	13.48	No	Yes	0	4	5
38	R:R:V130	R:R:W141	12.1611	3.68	No	Yes	0	4	7
39	R:R:I135	R:R:W367	11.9253	2.35	No	Yes	0	5	6
40	R:R:L143	R:R:W141	14.7675	14.81	Yes	Yes	0	5	7
41	R:R:C148	R:R:C227	18.6771	7.28	Yes	Yes	1	9	9
42	R:R:C148	R:R:F222	10.799	2.79	Yes	Yes	0	9	2
43	R:R:I152	R:R:W151	15.2849	3.52	Yes	Yes	1	5	5
44	R:R:I210	R:R:V156	19.4499	4.61	Yes	No	0	6	6
45	R:R:I152	R:R:I210	22.4492	4.42	Yes	Yes	0	5	6
46	L:L:?1	R:R:F339	15.3373	9.98	Yes	Yes	1	0	7
47	R:R:F339	R:R:N343	10.6876	7.25	Yes	No	0	7	7
48	R:R:N343	R:R:V235	12.0105	5.91	No	No	0	7	6
49	R:R:I210	R:R:P211	18.4938	3.39	Yes	No	0	6	5
50	L:L:?1	R:R:S242	18.3039	3.28	Yes	No	1	0	6
51	R:R:I206	R:R:S242	12.4427	3.1	Yes	No	1	6	6
52	R:R:F332	R:R:W336	46.9024	3.01	Yes	Yes	0	9	8
53	L:L:?1	R:R:F340	39.7446	8.65	Yes	Yes	1	0	7
54	R:R:F243	R:R:F340	53.3268	25.72	Yes	Yes	1	8	7
55	R:R:F243	R:R:F332	48.9587	5.36	Yes	Yes	1	8	9
56	R:R:I206	R:R:V241	14.3026	3.07	Yes	No	0	6	4
57	R:R:F240	R:R:V241	10.3405	2.62	No	No	0	4	4
58	R:R:F332	R:R:M250	88.114	7.46	Yes	No	0	9	8
59	R:R:F329	R:R:M250	86.0904	3.73	Yes	No	0	8	8
60	R:R:F329	R:R:Y254	76.6929	18.57	Yes	No	0	8	9
61	R:R:I258	R:R:Y254	71.9319	3.63	No	No	0	5	9
62	R:R:C322	R:R:I258	69.5285	1.64	No	No	0	7	5
63	R:R:C322	R:R:L261	64.9902	4.76	No	Yes	0	7	8
64	R:R:I177	R:R:L261	57.6228	8.56	No	Yes	0	9	8
65	R:R:I177	R:R:T257	34.1454	6.08	No	No	0	9	9
66	R:R:T257	R:R:Y174	31.6241	3.75	No	Yes	0	9	8
67	R:R:I177	R:R:S260	21.0151	3.1	No	No	0	9	6
68	R:R:Q178	R:R:S260	15.9856	4.33	No	No	0	6	6
69	R:R:V175	R:R:Y174	13.6477	1.26	No	Yes	0	5	8
70	R:R:H183	R:R:V175	10.943	1.38	Yes	No	0	7	5
71	R:R:N179	R:R:Q178	13.6477	9.24	No	No	0	6	6
72	R:R:P211	R:R:V212	11.9384	1.77	No	No	0	5	5
73	R:R:F234	R:R:I210	10.465	5.02	No	Yes	0	7	6
74	R:R:V235	R:R:V347	16.8107	3.21	No	No	0	6	5
75	R:R:L236	R:R:V347	12.685	2.98	No	No	0	6	5
76	R:R:M335	R:R:V375	10.9234	3.04	No	Yes	0	8	6
77	R:R:V375	R:R:V379	16.647	3.21	Yes	No	0	6	8
78	R:R:N376	R:R:V375	13.0517	2.96	Yes	Yes	0	9	6
79	R:R:F339	R:R:L362	19.2796	2.44	Yes	No	0	7	3
80	R:R:F339	R:R:V366	16.8173	3.93	Yes	No	0	7	6
81	R:R:V366	R:R:Y370	17.2168	6.31	No	Yes	0	6	7
82	R:R:H165	R:R:L116	11.3229	11.57	Yes	No	0	8	9
83	R:R:V127	R:R:Y370	10.3536	5.05	Yes	Yes	1	8	7
84	R:R:S373	R:R:T88	10.6876	3.2	No	No	0	9	7
85	R:R:F339	R:R:F340	12.5213	7.5	Yes	Yes	1	7	7
86	R:R:V127	R:R:W151	21.7616	9.81	Yes	Yes	1	8	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D155	5.19	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:V156	8.95	1	Yes	No	0	6	0	1
L:L:?1	R:R:S159	9.02	1	Yes	No	0	7	0	1
L:L:?1	R:R:S242	3.28	1	Yes	No	0	6	0	1
L:L:?1	R:R:F339	9.98	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F340	8.65	1	Yes	Yes	0	7	0	1
R:R:V127	R:R:W151	9.81	1	Yes	Yes	8	5	2	2
R:R:D155	R:R:V127	7.3	1	Yes	Yes	8	8	1	2
R:R:V127	R:R:Y370	5.05	1	Yes	Yes	8	7	2	2
R:R:D155	R:R:W151	3.35	1	Yes	Yes	8	5	1	2
R:R:D155	R:R:Y370	10.34	1	Yes	Yes	8	7	1	2
R:R:S207	R:R:V156	6.46	0	No	No	7	6	2	1
R:R:I210	R:R:V156	4.61	0	Yes	No	6	6	2	1
R:R:S159	R:R:W336	6.18	0	No	Yes	7	8	1	2
R:R:I206	R:R:T160	7.6	1	Yes	No	6	7	2	2
R:R:S242	R:R:T160	6.4	1	No	No	6	7	1	2
R:R:I206	R:R:S207	3.1	1	Yes	No	6	7	2	2
R:R:I206	R:R:S242	3.1	1	Yes	No	6	6	2	1
R:R:F340	R:R:S239	5.28	1	Yes	No	7	6	1	2
R:R:N343	R:R:S239	2.98	0	No	No	7	6	2	2
R:R:F243	R:R:F340	25.72	1	Yes	Yes	8	7	2	1
R:R:F339	R:R:F340	7.5	1	Yes	Yes	7	7	1	1
R:R:F339	R:R:N343	7.25	1	Yes	No	7	7	1	2
R:R:F339	R:R:V366	3.93	1	Yes	No	7	6	1	2
R:R:V366	R:R:Y370	6.31	0	No	Yes	6	7	2	2
R:R:F339	R:R:L362	2.44	1	Yes	No	7	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9AS2_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.94
Number of Linked Nodes	239
Number of Links	264
Number of Hubs	39
Number of Links mediated by Hubs	141
Number of Communities	4
Number of Nodes involved in Communities	34
Number of Links involved in Communities	46

Path Summary
Number Of Nodes in MetaPath	87
Number Of Links MetaPath	86
Number of Shortest Paths	39866
Length Of Smallest Path	3
Average Path Length	13.5835
Length of Longest Path	31
Minimum Path Strength	1.305
Average Path Strength	6.05843
Maximum Path Strength	17.685
Minimum Path Correlation	0.7
Average Path Correlation	0.917894
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	45.3411
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.7793
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1A
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1A
Name	6-AMINO HEXANOIC ACID
Synonyms
Identifier
Formula	C33 H40 N4 O6
Molecular Weight	588.694
SMILES
PubChem	5327090
Formal Charge	0
Total Atoms	83
Total Chiral Atoms	4
Total Bonds	86
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P28223
Sequence	>9AS2_nogp_Chain_R L L T A V V I I L T I A G N I L V I M A V S L E K K L Q N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G Y R W P L P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N P I H H S R F N S R T K A F L K I I A V W T I S V G I S M P I P V F G L D S K V F K E G S C L L A D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T Y R S A F S R Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6WGT	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WH4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WHA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.36	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WHA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-		3.36	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	8ZMG	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Pimavanserin	-	-	3.4	2024-08-28	doi.org/10.1021/acs.jmedchem.4c01244
	7RAN	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.45	2022-07-06	doi.org/10.1038/s41586-022-05258-z
	7RAN (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-		3.45	2022-07-06	doi.org/10.1038/s41586-022-05258-z
	7VOD	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Cariprazine	-	-	3.3	2021-12-22	doi.org/10.1038/s41593-021-00971-w
	7VOE	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Aripiprazole	-	-	2.9	2021-12-22	doi.org/10.1038/s41593-021-00971-w
	6A93	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Risperidone	-	-	3	2019-02-13	doi.org/10.1038/s41594-018-0180-z
	6A94	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Zotepine	-	-	2.9	2019-02-13	doi.org/10.1038/s41594-018-0180-z
	7WC4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	-	3.2	2022-01-26	doi.org/10.1126/science.abl8615
	7WC5	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	-	3.2	2022-01-26	doi.org/10.1126/science.abl8615
	7WC6	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	2.6	2022-01-26	doi.org/10.1126/science.abl8615
	7WC7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	-	2.6	2022-01-26	doi.org/10.1126/science.abl8615
	7WC8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lumateperone	-	-	2.45	2022-01-26	doi.org/10.1126/science.abl8615
	7WC9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 162421364	-	-	2.5	2022-01-26	doi.org/10.1126/science.abl8615
	8UWL	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.8	2024-05-29	doi.org/10.1126/science.adn6354
	8UWL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-		2.8	2024-05-29	doi.org/10.1126/science.adn6354
	8V6U	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 171392456	-	chim(NtGi2-Gs-CtGq)/β1/γ2	3	2024-05-29	doi.org/10.1126/science.adn6354
	8V6U (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 171392456	-		3	2024-05-29	doi.org/10.1126/science.adn6354
	8JT8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	(R)-IHCH-7179	-	-	2.7	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	9ARX	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	-	3.24	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARY	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.27	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARY (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-		3.27	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARZ	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-	-	3.37	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS0	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS0 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-		3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS1	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-	-	3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS2	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.21	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-		3.21	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS3	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.18	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.06	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS4 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-		3.06	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS5	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-	-	3.34	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS6	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-		3.07	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	-	2.72	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-	-	3.47	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ASA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.12	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ASA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-		3.12	2025-04-02	doi.org/10.1038/s41467-025-57956-7

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