psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D155	7.69	Yes	Yes	1	0	8
2	L:L:?1	R:R:S159	19.85	Yes	No	1	0	7
3	L:L:?1	R:R:T160	2.78	Yes	Yes	1	0	7
4	L:L:?1	R:R:S242	4.25	Yes	No	1	0	6
5	L:L:?1	R:R:W336	8.61	Yes	Yes	1	0	8
6	L:L:?1	R:R:F339	10.35	Yes	Yes	1	0	7
7	L:L:?1	R:R:F340	21.86	Yes	Yes	1	0	7
8	L:L:?1	R:R:V366	2.81	Yes	No	1	0	6
9	L:L:?1	R:R:G369	9.69	Yes	No	0	0	7
10	L:L:?1	R:R:Y370	5.54	Yes	Yes	1	0	7
11	R:R:M128	R:R:V84	3.04	Yes	No	0	8	7
12	R:R:I85	R:R:I89	2.94	No	No	0	6	5
13	R:R:I85	R:R:M128	7.29	No	Yes	0	6	8
14	R:R:A374	R:R:T88	5.03	No	No	0	6	7
15	R:R:I89	R:R:N92	4.25	No	No	0	5	9
16	R:R:F125	R:R:I89	6.28	No	No	0	4	5
17	R:R:M121	R:R:N92	11.22	No	No	0	7	9
18	R:R:I93	R:R:M97	2.92	Yes	No	0	3	4
19	R:R:F391	R:R:V95	2.62	No	No	0	6	9
20	R:R:I96	R:R:M114	4.37	Yes	No	0	6	5
21	R:R:I118	R:R:I96	2.94	No	Yes	0	6	6
22	R:R:A98	R:R:F391	2.77	No	No	0	7	6
23	R:R:V99	R:R:Y387	5.05	No	Yes	0	7	8
24	R:R:L105	R:R:T386	2.95	No	No	0	8	6
25	R:R:L105	R:R:Y387	8.21	No	Yes	0	8	8
26	R:R:Q106	R:R:Y111	3.38	No	No	0	7	4
27	R:R:N107	R:R:T109	4.39	No	No	0	7	8
28	R:R:N110	R:R:T109	4.39	No	No	0	9	8
29	R:R:N110	R:R:Y387	6.98	No	Yes	0	9	8
30	R:R:M114	R:R:Y111	3.59	No	No	0	5	4
31	R:R:F112	R:R:H165	3.39	Yes	Yes	0	8	8
32	R:R:A168	R:R:F112	2.77	No	Yes	0	7	8
33	R:R:F112	R:R:I169	2.51	Yes	No	0	8	9
34	R:R:F112	R:R:K195	14.89	Yes	No	0	8	6
35	R:R:F112	R:R:I196	2.51	Yes	No	0	8	8
36	R:R:L113	R:R:T381	2.95	No	No	0	8	7
37	R:R:H165	R:R:S115	8.37	Yes	No	2	8	9
38	R:R:S115	R:R:W200	2.47	No	Yes	2	9	9
39	R:R:H165	R:R:L116	6.43	Yes	No	0	8	9
40	R:R:I118	R:R:M121	2.92	No	No	0	6	7
41	R:R:A119	R:R:W200	2.59	No	Yes	0	8	9
42	R:R:D120	R:R:S373	5.89	No	No	0	9	9
43	R:R:D120	R:R:N376	2.69	No	Yes	3	9	9
44	R:R:D120	R:R:P377	3.22	No	No	3	9	9
45	R:R:L122	R:R:M121	2.83	No	No	0	7	7
46	R:R:F158	R:R:L122	10.96	Yes	No	0	7	7
47	R:R:L123	R:R:V127	7.45	Yes	No	1	7	8
48	R:R:D155	R:R:L123	4.07	Yes	Yes	1	8	7
49	R:R:F158	R:R:L123	6.09	Yes	Yes	0	7	7
50	R:R:L123	R:R:Y370	4.69	Yes	Yes	1	7	7
51	R:R:L123	R:R:S373	3	Yes	No	0	7	9
52	R:R:G124	R:R:M128	3.49	No	Yes	0	6	8
53	R:R:L126	R:R:L154	2.77	No	No	0	5	5
54	R:R:D155	R:R:V127	8.76	Yes	No	1	8	8
55	R:R:V127	R:R:Y370	5.05	No	Yes	1	8	7
56	R:R:M128	R:R:W367	4.65	Yes	Yes	1	8	6
57	R:R:M128	R:R:Y370	8.38	Yes	Yes	1	8	7
58	R:R:V130	R:R:W151	13.48	No	Yes	0	4	5
59	R:R:S131	R:R:W151	2.47	No	Yes	1	7	5
60	R:R:S131	R:R:W367	2.47	No	Yes	1	7	6
61	R:R:S131	R:R:Y370	5.09	No	Yes	1	7	7
62	R:R:I135	R:R:N363	7.08	No	No	0	5	4
63	R:R:R140	R:R:Y137	5.14	No	No	0	4	4
64	R:R:P142	R:R:Y137	27.82	No	No	0	3	4
65	R:R:G138	R:R:Y139	5.79	No	No	0	5	3
66	R:R:C148	R:R:W141	6.53	No	No	1	9	7
67	R:R:C227	R:R:W141	13.06	Yes	No	1	9	7
68	R:R:C148	R:R:V221	3.42	No	Yes	0	9	3
69	R:R:C148	R:R:C227	7.28	No	Yes	1	9	9
70	R:R:A149	R:R:V221	3.39	No	Yes	0	6	3
71	R:R:I152	R:R:W151	3.52	Yes	Yes	1	5	5
72	R:R:C227	R:R:W151	2.61	Yes	Yes	1	9	5
73	R:R:I152	R:R:V221	3.07	Yes	Yes	0	5	3
74	R:R:C227	R:R:I152	3.27	Yes	Yes	1	9	5
75	R:R:I152	R:R:L229	4.28	Yes	No	0	5	4
76	R:R:L154	R:R:Y153	3.52	No	Yes	0	5	6
77	R:R:S207	R:R:Y153	2.54	No	Yes	0	7	6
78	R:R:P211	R:R:Y153	11.13	No	Yes	0	5	6
79	R:R:F158	R:R:L154	3.65	Yes	No	0	7	5
80	R:R:D155	R:R:S159	2.94	Yes	No	1	8	7
81	R:R:D155	R:R:Y370	4.6	Yes	Yes	1	8	7
82	R:R:S207	R:R:V156	4.85	No	No	0	7	6
83	R:R:F158	R:R:L157	4.87	Yes	No	0	7	6
84	R:R:L157	R:R:V204	2.98	No	No	0	6	4
85	R:R:L157	R:R:S207	7.51	No	No	0	6	7
86	R:R:M164	R:R:T160	3.01	No	Yes	0	6	7
87	R:R:I206	R:R:T160	4.56	No	Yes	0	6	7
88	R:R:S242	R:R:T160	4.8	No	Yes	1	6	7
89	R:R:A161	R:R:W200	3.89	No	Yes	2	8	9
90	R:R:A161	R:R:S203	3.42	No	No	2	8	8
91	R:R:I163	R:R:P246	5.08	No	No	0	8	9
92	R:R:I163	R:R:W336	9.4	No	Yes	0	8	8
93	R:R:H165	R:R:V199	11.07	Yes	No	0	8	6
94	R:R:H165	R:R:W200	3.17	Yes	Yes	2	8	9
95	R:R:L166	R:R:N376	4.12	No	Yes	0	8	9
96	R:R:L166	R:R:Y380	4.69	No	No	0	8	9
97	R:R:C167	R:R:P246	3.77	No	No	0	6	9
98	R:R:I169	R:R:R173	2.51	No	No	0	9	9
99	R:R:S170	R:R:T253	6.4	No	Yes	0	9	5
100	R:R:D172	R:R:H183	2.52	No	No	0	9	7
101	R:R:L325	R:R:R173	3.64	No	No	0	8	9
102	R:R:Q178	R:R:Y174	11.27	No	Yes	0	6	8
103	R:R:T253	R:R:Y174	2.5	Yes	Yes	0	5	8
104	R:R:L256	R:R:Y174	7.03	No	Yes	0	5	8
105	R:R:T257	R:R:Y174	6.24	No	Yes	0	9	8
106	R:R:A176	R:R:H183	7.32	No	No	0	8	7
107	R:R:I177	R:R:L261	4.28	No	Yes	0	9	8
108	R:R:N179	R:R:Q178	6.6	Yes	No	0	6	6
109	R:R:H182	R:R:N179	2.55	No	Yes	0	5	6
110	R:R:H182	R:R:I181	2.65	No	No	0	5	7
111	R:R:I181	R:R:R185	3.76	No	No	0	7	4
112	R:R:F186	R:R:R185	4.28	No	No	0	4	4
113	R:R:F193	R:R:I197	13.82	No	No	0	4	2
114	R:R:S203	R:R:W200	2.47	No	Yes	2	8	9
115	R:R:M208	R:R:P209	3.35	No	No	0	4	7
116	R:R:F234	R:R:P209	5.78	Yes	No	0	7	7
117	R:R:I210	R:R:P211	3.39	No	No	0	6	5
118	R:R:F234	R:R:I210	2.51	Yes	No	0	7	6
119	R:R:F213	R:R:K220	3.72	No	No	0	4	3
120	R:R:D218	R:R:F222	7.17	No	No	0	3	2
121	R:R:A230	R:R:K223	4.82	No	No	0	3	3
122	R:R:L228	R:R:S226	9.01	No	No	0	4	4
123	R:R:D231	R:R:D232	3.99	No	No	5	5	4
124	R:R:D231	R:R:N233	9.42	No	No	5	5	3
125	R:R:D231	R:R:F234	4.78	No	Yes	0	5	7
126	R:R:D232	R:R:N233	12.12	No	No	5	4	3
127	R:R:D232	R:R:V347	4.38	No	No	0	4	5
128	R:R:F234	R:R:I237	6.28	Yes	No	0	7	4
129	R:R:G238	R:R:I237	3.53	No	No	0	6	4
130	R:R:F240	R:R:F244	3.22	No	No	0	4	5
131	R:R:F243	R:R:W336	4.01	No	Yes	1	8	8
132	R:R:F243	R:R:F340	9.65	No	Yes	1	8	7
133	R:R:I245	R:R:P246	3.39	No	No	0	5	9
134	R:R:I245	R:R:I249	2.94	No	No	6	5	6
135	R:R:L247	R:R:V251	2.98	No	No	0	6	5
136	R:R:F329	R:R:M250	2.49	No	No	0	8	8
137	R:R:F332	R:R:M250	6.22	No	No	0	9	8
138	R:R:F329	R:R:V251	2.62	No	No	0	8	5
139	R:R:I258	R:R:Y254	6.04	No	No	0	5	9
140	R:R:G326	R:R:Y254	4.35	No	No	0	6	9
141	R:R:F329	R:R:Y254	8.25	No	No	0	8	9
142	R:R:C322	R:R:I258	3.27	No	No	0	7	5
143	R:R:I258	R:R:L325	2.85	No	No	0	5	8
144	R:R:C322	R:R:L261	3.17	No	Yes	0	7	8
145	R:R:K320	R:R:N317	6.99	No	No	0	8	6
146	R:R:F383	R:R:V324	9.18	No	No	0	7	8
147	R:R:F330	R:R:V333	2.62	No	No	0	5	6
148	R:R:L331	R:R:M335	4.24	No	Yes	0	6	8
149	R:R:F332	R:R:W336	9.02	No	Yes	0	9	8
150	R:R:C337	R:R:V333	3.42	No	No	0	6	6
151	R:R:M335	R:R:S372	10.73	Yes	No	0	8	9
152	R:R:M335	R:R:V375	3.04	Yes	No	0	8	6
153	R:R:F340	R:R:W336	3.01	Yes	Yes	1	7	8
154	R:R:S372	R:R:W336	6.18	No	Yes	0	9	8
155	R:R:F365	R:R:P338	4.33	Yes	No	0	5	9
156	R:R:F339	R:R:F340	7.5	Yes	Yes	1	7	7
157	R:R:F365	R:R:T342	2.59	Yes	No	0	5	5
158	R:R:N354	R:R:V357	5.91	No	No	0	1	5
159	R:R:L361	R:R:V357	2.98	No	No	0	4	5
160	R:R:F365	R:R:L361	7.31	Yes	No	0	5	4
161	R:R:N363	R:R:W367	7.91	No	Yes	0	4	6
162	R:R:V366	R:R:Y370	5.05	No	Yes	1	6	7
163	R:R:W367	R:R:Y370	9.65	Yes	Yes	1	6	7
164	R:R:L371	R:R:V375	2.98	No	No	0	4	6
165	R:R:N376	R:R:P377	3.26	Yes	No	3	9	9
166	R:R:T381	R:R:Y387	17.48	No	Yes	0	7	8
167	R:R:F391	R:R:T381	2.59	No	No	0	6	7
168	R:R:N384	R:R:Y387	6.98	No	Yes	0	9	8
169	R:R:K385	R:R:T386	4.5	No	No	0	5	6
170	R:R:R393	R:R:S389	3.95	No	No	0	4	4
171	R:R:A390	R:R:R393	2.77	No	No	0	7	4
172	R:R:F339	R:R:L362	2.44	Yes	No	0	7	3
173	R:R:T134	R:R:W141	2.43	No	No	0	5	7
174	R:R:L133	R:R:Y137	2.34	No	No	0	4	4
175	R:R:F339	R:R:F365	2.14	Yes	Yes	0	7	5
176	R:R:A90	R:R:G91	1.95	No	No	0	4	8
177	R:R:C337	R:R:P338	1.88	No	No	0	6	9
178	R:R:G205	R:R:V204	1.84	No	No	0	4	4
179	R:R:G214	R:R:V221	1.84	No	Yes	0	7	3
180	R:R:P377	R:R:V95	1.77	No	No	0	9	9
181	R:R:G369	R:R:I368	1.76	No	No	0	7	7
182	R:R:G91	R:R:L378	1.71	No	No	0	8	6
183	R:R:G359	R:R:L362	1.71	No	No	0	2	3
184	R:R:A346	R:R:V347	1.7	No	No	0	4	5
185	R:R:M128	R:R:P129	1.68	Yes	No	0	8	8
186	R:R:N179	R:R:P180	1.63	Yes	No	0	6	8
187	R:R:S389	R:R:S392	1.63	No	No	0	4	3
188	R:R:A90	R:R:I93	1.62	No	Yes	0	4	3
189	R:R:A117	R:R:I96	1.62	No	Yes	0	9	6
190	R:R:A346	R:R:M345	1.61	No	No	0	4	4
191	R:R:S188	R:R:T190	1.6	No	No	0	7	5
192	R:R:V324	R:R:V328	1.6	No	No	0	8	8
193	R:R:V328	R:R:V379	1.6	No	No	4	8	8
194	R:R:S389	R:R:T386	1.6	No	No	0	4	6
195	R:R:T88	R:R:V84	1.59	No	No	0	7	7
196	R:R:A149	R:R:L215	1.58	No	No	0	6	5
197	R:R:A321	R:R:L261	1.58	No	Yes	0	8	8
198	R:R:A108	R:R:N107	1.56	No	No	0	5	7
199	R:R:I177	R:R:S260	1.55	No	No	0	9	6
200	R:R:K220	R:R:S219	1.53	No	No	0	3	3
201	R:R:K223	R:R:S226	1.53	No	No	0	3	4
202	R:R:I197	R:R:T201	1.52	No	No	0	2	4
203	R:R:I245	R:R:T248	1.52	No	No	6	5	3
204	R:R:I249	R:R:T248	1.52	No	No	6	6	3
205	R:R:I249	R:R:T253	1.52	No	Yes	0	6	5
206	R:R:M335	R:R:V334	1.52	Yes	No	0	8	5
207	R:R:I341	R:R:T342	1.52	No	No	0	6	5
208	R:R:F213	R:R:G214	1.51	No	No	0	4	7
209	R:R:F222	R:R:G225	1.51	No	No	0	2	3
210	R:R:L147	R:R:V150	1.49	No	No	0	5	4
211	R:R:N376	R:R:S162	1.49	Yes	No	0	9	9
212	R:R:N317	R:R:S316	1.49	No	No	0	6	6
213	R:R:N179	R:R:V175	1.48	Yes	No	0	6	5
214	R:R:N343	R:R:V235	1.48	No	No	0	7	6
215	R:R:I93	R:R:I96	1.47	Yes	Yes	0	3	6
216	R:R:L171	R:R:T253	1.47	No	Yes	0	6	5
217	R:R:D217	R:R:S219	1.47	No	No	0	4	3
218	R:R:I341	R:R:I344	1.47	No	No	0	6	5
219	R:R:I85	R:R:M132	1.46	No	No	0	6	6
220	R:R:I86	R:R:L87	1.43	No	No	0	4	4
221	R:R:I93	R:R:L94	1.43	Yes	No	0	3	6
222	R:R:Q216	R:R:V212	1.43	No	No	0	6	5
223	R:R:I344	R:R:L236	1.43	No	No	0	5	6
224	R:R:I252	R:R:L256	1.43	No	No	0	5	5
225	R:R:I327	R:R:L331	1.43	No	No	0	6	6
226	R:R:I358	R:R:L362	1.43	No	No	0	4	3
227	L:L:?1	R:R:V235	1.41	Yes	No	0	0	6
228	R:R:L133	R:R:M132	1.41	No	No	0	4	6
229	R:R:D172	R:R:K195	1.38	No	No	0	9	6
230	R:R:L378	R:R:L382	1.38	No	No	0	6	5
231	R:R:E318	R:R:L261	1.33	No	Yes	0	8	8
232	R:R:F340	R:R:S239	1.32	Yes	No	0	7	6
233	R:R:F240	R:R:V241	1.31	No	No	0	4	4
234	R:R:F365	R:R:V364	1.31	Yes	No	0	5	4
235	R:R:H183	R:R:N187	1.28	No	No	0	7	6
236	R:R:V150	R:R:Y153	1.26	No	Yes	0	4	6
237	R:R:V328	R:R:Y380	1.26	No	No	4	8	9
238	R:R:V379	R:R:Y380	1.26	No	No	4	8	9
239	R:R:L382	R:R:R388	1.21	No	No	0	5	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.62182	11	1	0
2	R:R:I93	1.86	4	0	3
3	R:R:I96	2.6	4	0	6
4	R:R:F112	5.214	5	0	8
5	R:R:L123	5.06	5	1	7
6	R:R:M128	4.755	6	1	8
7	R:R:W151	5.52	4	1	5
8	R:R:I152	3.535	4	1	5
9	R:R:Y153	4.6125	4	0	6
10	R:R:D155	5.612	5	1	8
11	R:R:F158	6.3925	4	0	7
12	R:R:T160	3.7875	4	1	7
13	R:R:H165	6.486	5	2	8
14	R:R:Y174	6.76	4	0	8
15	R:R:N179	3.065	4	0	6
16	R:R:W200	2.918	5	2	9
17	R:R:V221	2.93	4	0	3
18	R:R:C227	6.555	4	1	9
19	R:R:F234	4.8375	4	0	7
20	R:R:T253	2.9725	4	0	5
21	R:R:L261	2.59	4	0	8
22	R:R:M335	4.8825	4	0	8
23	R:R:W336	6.705	6	1	8
24	R:R:F339	5.6075	4	1	7
25	R:R:F340	8.668	5	1	7
26	R:R:F365	3.536	5	0	5
27	R:R:W367	6.17	4	1	6
28	R:R:Y370	6.00625	8	1	7
29	R:R:N376	2.89	4	3	9
30	R:R:Y387	8.94	5	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y370	75.5766	5.54	Yes	Yes	1	0	7
2	R:R:M128	R:R:Y370	18.9154	8.38	Yes	Yes	1	8	7
3	R:R:I85	R:R:M128	13.8471	7.29	No	Yes	0	6	8
4	L:L:?1	R:R:D155	51.1996	7.69	Yes	Yes	1	0	8
5	R:R:D155	R:R:L123	50.8833	4.07	Yes	Yes	1	8	7
6	R:R:F158	R:R:L123	75.9006	6.09	Yes	Yes	0	7	7
7	R:R:F158	R:R:L122	33.4413	10.96	Yes	No	0	7	7
8	R:R:L122	R:R:M121	31.5436	2.83	No	No	0	7	7
9	R:R:L123	R:R:Y370	66.9135	4.69	Yes	Yes	1	7	7
10	R:R:I118	R:R:M121	30.6642	2.92	No	No	0	6	7
11	R:R:I118	R:R:I96	28.5736	2.94	No	Yes	0	6	6
12	R:R:I93	R:R:I96	17.8894	1.47	Yes	Yes	0	3	6
13	R:R:L123	R:R:S373	59.9784	3	Yes	No	0	7	9
14	R:R:D120	R:R:S373	58.1578	5.89	No	No	0	9	9
15	R:R:D120	R:R:P377	40.2299	3.22	No	No	3	9	9
16	R:R:P377	R:R:V95	39.4662	1.77	No	No	0	9	9
17	R:R:F391	R:R:V95	37.4296	2.62	No	No	0	6	9
18	R:R:F391	R:R:T381	33.5956	2.59	No	No	0	6	7
19	R:R:T381	R:R:Y387	29.7693	17.48	No	Yes	0	7	8
20	R:R:L105	R:R:Y387	15.2357	8.21	No	Yes	0	8	8
21	R:R:L105	R:R:T386	13.3611	2.95	No	No	0	8	6
22	L:L:?1	R:R:W336	100	8.61	Yes	Yes	1	0	8
23	R:R:F332	R:R:W336	64.175	9.02	No	Yes	0	9	8
24	R:R:F332	R:R:M250	62.4238	6.22	No	No	0	9	8
25	R:R:F329	R:R:M250	60.8347	2.49	No	No	0	8	8
26	R:R:F329	R:R:Y254	55.4038	8.25	No	No	0	8	9
27	R:R:I258	R:R:Y254	51.7473	6.04	No	No	0	5	9
28	R:R:I258	R:R:L325	38.7796	2.85	No	No	0	5	8
29	R:R:L325	R:R:R173	37.013	3.64	No	No	0	8	9
30	R:R:I169	R:R:R173	35.2388	2.51	No	No	0	9	9
31	R:R:F112	R:R:I169	33.233	2.51	Yes	No	0	8	9
32	R:R:F112	R:R:H165	17.4188	3.39	Yes	Yes	0	8	8
33	R:R:F112	R:R:K195	10.5068	14.89	Yes	No	0	8	6
34	R:R:D120	R:R:N376	16.0842	2.69	No	Yes	3	9	9
35	R:R:F158	R:R:L154	37.1056	3.65	Yes	No	0	7	5
36	R:R:S131	R:R:Y370	23.3356	5.09	No	Yes	1	7	7
37	R:R:S131	R:R:W151	24.3308	2.47	No	Yes	1	7	5
38	R:R:I152	R:R:W151	15.4362	3.52	Yes	Yes	1	5	5
39	R:R:I152	R:R:V221	12.636	3.07	Yes	Yes	0	5	3
40	R:R:L154	R:R:Y153	33.3025	3.52	No	Yes	0	5	6
41	R:R:F158	R:R:L157	10.53	4.87	Yes	No	0	7	6
42	R:R:P211	R:R:Y153	27.7328	11.13	No	Yes	0	5	6
43	R:R:I163	R:R:W336	43.7322	9.4	No	Yes	0	8	8
44	R:R:I163	R:R:P246	41.8036	5.08	No	No	0	8	9
45	R:R:L166	R:R:N376	12.96	4.12	No	Yes	0	8	9
46	R:R:L166	R:R:Y380	10.7614	4.69	No	No	0	8	9
47	R:R:I245	R:R:P246	37.9002	3.39	No	No	0	5	9
48	R:R:I245	R:R:I249	33.8116	2.94	No	No	6	5	6
49	R:R:I249	R:R:T253	31.9293	1.52	No	Yes	0	6	5
50	R:R:T253	R:R:Y174	25.8196	2.5	Yes	Yes	0	5	8
51	R:R:Q178	R:R:Y174	17.4574	11.27	No	Yes	0	6	8
52	R:R:C322	R:R:I258	12.7902	3.27	No	No	0	7	5
53	R:R:C322	R:R:L261	10.8308	3.17	No	Yes	0	7	8
54	R:R:N179	R:R:Q178	15.3282	6.6	Yes	No	0	6	6
55	R:R:I210	R:R:P211	25.6499	3.39	No	No	0	6	5
56	R:R:F234	R:R:I210	23.5362	2.51	Yes	No	0	7	6
57	R:R:D231	R:R:F234	13.0911	4.78	No	Yes	0	5	7
58	L:L:?1	R:R:F339	33.0556	10.35	Yes	Yes	1	0	7
59	R:R:F339	R:R:F365	32.3845	2.14	Yes	Yes	0	7	5
60	R:R:F365	R:R:P338	10.2368	4.33	Yes	No	0	5	9
61	R:R:S372	R:R:W336	15.3282	6.18	No	Yes	0	9	8
62	R:R:M335	R:R:S372	13.1837	10.73	Yes	No	0	8	9
63	R:R:F365	R:R:T342	10.2368	2.59	Yes	No	0	5	5
64	R:R:A90	R:R:I93	11.2937	1.62	No	Yes	0	4	3

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D155	7.69	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:S159	19.85	1	Yes	No	0	7	0	1
L:L:?1	R:R:T160	2.78	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:S242	4.25	1	Yes	No	0	6	0	1
L:L:?1	R:R:W336	8.61	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F339	10.35	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F340	21.86	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:V366	2.81	1	Yes	No	0	6	0	1
L:L:?1	R:R:G369	9.69	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y370	5.54	1	Yes	Yes	0	7	0	1
R:R:L123	R:R:V127	7.45	1	Yes	No	7	8	2	2
R:R:D155	R:R:L123	4.07	1	Yes	Yes	8	7	1	2
R:R:L123	R:R:Y370	4.69	1	Yes	Yes	7	7	2	1
R:R:D155	R:R:V127	8.76	1	Yes	No	8	8	1	2
R:R:V127	R:R:Y370	5.05	1	No	Yes	8	7	2	1
R:R:M128	R:R:W367	4.65	1	Yes	Yes	8	6	2	2
R:R:M128	R:R:Y370	8.38	1	Yes	Yes	8	7	2	1
R:R:S131	R:R:W367	2.47	1	No	Yes	7	6	2	2
R:R:S131	R:R:Y370	5.09	1	No	Yes	7	7	2	1
R:R:D155	R:R:S159	2.94	1	Yes	No	8	7	1	1
R:R:D155	R:R:Y370	4.6	1	Yes	Yes	8	7	1	1
R:R:M164	R:R:T160	3.01	0	No	Yes	6	7	2	1
R:R:I206	R:R:T160	4.56	0	No	Yes	6	7	2	1
R:R:S242	R:R:T160	4.8	1	No	Yes	6	7	1	1
R:R:I163	R:R:W336	9.4	0	No	Yes	8	8	2	1
R:R:F243	R:R:W336	4.01	1	No	Yes	8	8	2	1
R:R:F243	R:R:F340	9.65	1	No	Yes	8	7	2	1
R:R:F332	R:R:W336	9.02	0	No	Yes	9	8	2	1
R:R:F340	R:R:W336	3.01	1	Yes	Yes	7	8	1	1
R:R:S372	R:R:W336	6.18	0	No	Yes	9	8	2	1
R:R:F339	R:R:F340	7.5	1	Yes	Yes	7	7	1	1
R:R:V366	R:R:Y370	5.05	1	No	Yes	6	7	1	1
R:R:W367	R:R:Y370	9.65	1	Yes	Yes	6	7	2	1
R:R:F339	R:R:L362	2.44	1	Yes	No	7	3	1	2
R:R:F339	R:R:F365	2.14	1	Yes	Yes	7	5	1	2
R:R:G369	R:R:I368	1.76	0	No	No	7	7	1	2
R:R:N343	R:R:V235	1.48	0	No	No	7	6	2	1
L:L:?1	R:R:V235	1.41	1	Yes	No	0	6	0	1
R:R:F340	R:R:S239	1.32	1	Yes	No	7	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6WHA_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.47
Number of Linked Nodes	226
Number of Links	239
Number of Hubs	30
Number of Links mediated by Hubs	119
Number of Communities	6
Number of Nodes involved in Communities	38
Number of Links involved in Communities	52

Path Summary
Number Of Nodes in MetaPath	65
Number Of Links MetaPath	64
Number of Shortest Paths	27751
Length Of Smallest Path	3
Average Path Length	13.1587
Length of Longest Path	29
Minimum Path Strength	1.295
Average Path Strength	5.0376
Maximum Path Strength	20.855
Minimum Path Correlation	0.7
Average Path Correlation	0.913979
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	44.7926
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.31
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	U0G
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	U0G
Name	N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine
Synonyms	25CN-NBOH N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine NBOH-2C-CN
Identifier
Formula	C18 H20 N2 O3
Molecular Weight	312.363
SMILES
PubChem	90489020
Formal Charge	0
Total Atoms	43
Total Chiral Atoms	0
Total Bonds	44
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P28223
Sequence	>6WHA_nogp_Chain_R V I I L T I A G N I L V I M A V L Q N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G Y R W P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N P I H H S R F N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D S K V F K G S C L L A D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T Y R S A F S R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6WGT	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WH4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WHA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.36	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WHA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-		3.36	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	8ZMG	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Pimavanserin	-	-	3.4	2024-08-28	doi.org/10.1021/acs.jmedchem.4c01244
	7RAN	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.45	2022-07-06	doi.org/10.1038/s41586-022-05258-z
	7RAN (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-		3.45	2022-07-06	doi.org/10.1038/s41586-022-05258-z
	7VOD	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Cariprazine	-	-	3.3	2021-12-22	doi.org/10.1038/s41593-021-00971-w
	7VOE	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Aripiprazole	-	-	2.9	2021-12-22	doi.org/10.1038/s41593-021-00971-w
	6A93	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Risperidone	-	-	3	2019-02-13	doi.org/10.1038/s41594-018-0180-z
	6A94	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Zotepine	-	-	2.9	2019-02-13	doi.org/10.1038/s41594-018-0180-z
	7WC4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	-	3.2	2022-01-26	doi.org/10.1126/science.abl8615
	7WC5	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	-	3.2	2022-01-26	doi.org/10.1126/science.abl8615
	7WC6	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	2.6	2022-01-26	doi.org/10.1126/science.abl8615
	7WC7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	-	2.6	2022-01-26	doi.org/10.1126/science.abl8615
	7WC8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lumateperone	-	-	2.45	2022-01-26	doi.org/10.1126/science.abl8615
	7WC9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 162421364	-	-	2.5	2022-01-26	doi.org/10.1126/science.abl8615
	8UWL	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.8	2024-05-29	doi.org/10.1126/science.adn6354
	8UWL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-		2.8	2024-05-29	doi.org/10.1126/science.adn6354
	8V6U	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 171392456	-	chim(NtGi2-Gs-CtGq)/β1/γ2	3	2024-05-29	doi.org/10.1126/science.adn6354
	8V6U (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 171392456	-		3	2024-05-29	doi.org/10.1126/science.adn6354
	8JT8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	(R)-IHCH-7179	-	-	2.7	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	9ARX	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	-	3.24	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARY	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.27	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARY (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-		3.27	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARZ	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-	-	3.37	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS0	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS0 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-		3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS1	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-	-	3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS2	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.21	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-		3.21	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS3	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.18	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.06	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS4 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-		3.06	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS5	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-	-	3.34	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS6	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-		3.07	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	-	2.72	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-	-	3.47	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ASA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.12	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ASA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-		3.12	2025-04-02	doi.org/10.1038/s41467-025-57956-7

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