psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D155	9.23	Yes	Yes	1	0	8
2	L:L:?1	R:R:V156	11.4	Yes	No	1	0	6
3	L:L:?1	R:R:S159	8.94	Yes	No	1	0	7
4	L:L:?1	R:R:V235	3.8	Yes	Yes	1	0	6
5	L:L:?1	R:R:G238	2.91	Yes	No	0	0	6
6	L:L:?1	R:R:S239	3.83	Yes	No	1	0	6
7	L:L:?1	R:R:S242	8.94	Yes	No	0	0	6
8	L:L:?1	R:R:F339	8.29	Yes	No	1	0	7
9	L:L:?1	R:R:F340	12.43	Yes	Yes	1	0	7
10	L:L:?1	R:R:N343	3.5	Yes	No	1	0	7
11	R:R:L79	R:R:T81	7.37	No	No	0	4	6
12	R:R:M132	R:R:T81	6.02	No	No	0	6	6
13	R:R:T81	R:R:W367	16.98	No	Yes	0	6	6
14	R:R:M128	R:R:V84	3.04	Yes	No	0	8	7
15	R:R:L371	R:R:V84	4.47	No	No	0	4	7
16	R:R:I85	R:R:M128	2.92	No	Yes	0	6	8
17	R:R:A374	R:R:L87	3.15	No	No	0	6	4
18	R:R:N92	R:R:T88	2.92	Yes	No	0	9	7
19	R:R:A374	R:R:T88	3.36	No	No	0	6	7
20	R:R:I89	R:R:I93	4.42	No	No	0	5	3
21	R:R:F125	R:R:I89	6.28	No	No	0	4	5
22	R:R:D120	R:R:N92	5.39	Yes	Yes	0	9	9
23	R:R:M121	R:R:N92	8.41	No	Yes	0	7	9
24	R:R:N92	R:R:P377	8.15	Yes	No	0	9	9
25	R:R:T381	R:R:V95	4.76	Yes	No	0	7	9
26	R:R:I96	R:R:M114	4.37	Yes	No	0	6	5
27	R:R:A117	R:R:I96	3.25	No	Yes	0	9	6
28	R:R:I118	R:R:I96	2.94	No	Yes	0	6	6
29	R:R:M114	R:R:V99	4.56	No	No	0	5	7
30	R:R:V99	R:R:Y387	3.79	No	Yes	0	7	8
31	R:R:E102	R:R:K104	4.05	No	No	0	6	6
32	R:R:E102	R:R:L105	9.28	No	Yes	2	6	8
33	R:R:E102	R:R:T386	4.23	No	No	2	6	6
34	R:R:L105	R:R:N110	4.12	Yes	No	2	8	9
35	R:R:L105	R:R:T386	8.84	Yes	No	2	8	6
36	R:R:L105	R:R:Y387	10.55	Yes	Yes	2	8	8
37	R:R:N110	R:R:Y387	8.14	No	Yes	2	9	8
38	R:R:M114	R:R:Y111	5.99	No	No	0	5	4
39	R:R:F112	R:R:H165	7.92	No	Yes	3	8	8
40	R:R:F112	R:R:K195	7.44	No	No	0	8	6
41	R:R:F112	R:R:V199	3.93	No	No	3	8	6
42	R:R:L113	R:R:T381	4.42	No	Yes	2	8	7
43	R:R:L113	R:R:Y387	3.52	No	Yes	2	8	8
44	R:R:H165	R:R:S115	6.97	Yes	No	3	8	9
45	R:R:I196	R:R:S115	7.74	No	No	0	8	9
46	R:R:S115	R:R:W200	3.71	No	Yes	3	9	9
47	R:R:D120	R:R:L116	4.07	Yes	No	0	9	9
48	R:R:H165	R:R:L116	10.29	Yes	No	0	8	9
49	R:R:L116	R:R:L166	4.15	No	Yes	0	9	8
50	R:R:D120	R:R:S162	5.89	Yes	No	0	9	9
51	R:R:D120	R:R:S373	8.83	Yes	No	0	9	9
52	R:R:F158	R:R:L122	9.74	Yes	No	0	7	7
53	R:R:L123	R:R:V127	2.98	No	Yes	0	7	8
54	R:R:F158	R:R:L123	6.09	Yes	No	0	7	7
55	R:R:L123	R:R:S373	3	No	No	0	7	9
56	R:R:G124	R:R:M128	5.24	No	Yes	0	6	8
57	R:R:L126	R:R:L154	6.92	No	No	4	5	5
58	R:R:F158	R:R:L126	3.65	Yes	No	4	7	5
59	R:R:V127	R:R:W151	3.68	Yes	Yes	1	8	5
60	R:R:D155	R:R:V127	4.38	Yes	Yes	1	8	8
61	R:R:V127	R:R:Y370	3.79	Yes	Yes	1	8	7
62	R:R:M128	R:R:W367	3.49	Yes	Yes	1	8	6
63	R:R:M128	R:R:Y370	8.38	Yes	Yes	1	8	7
64	R:R:V130	R:R:W151	8.58	No	Yes	0	4	5
65	R:R:S131	R:R:W367	9.88	No	Yes	0	7	6
66	R:R:L133	R:R:Y137	3.52	No	Yes	1	4	4
67	R:R:L133	R:R:P142	9.85	No	No	1	4	3
68	R:R:T134	R:R:Y139	7.49	No	Yes	0	5	3
69	R:R:I135	R:R:N363	5.66	No	No	0	5	4
70	R:R:I135	R:R:W367	3.52	No	Yes	0	5	6
71	R:R:R140	R:R:Y137	12.35	No	Yes	0	4	4
72	R:R:P142	R:R:Y137	18.08	No	Yes	1	3	4
73	R:R:N363	R:R:Y139	11.63	No	Yes	0	4	3
74	R:R:P142	R:R:W141	5.4	No	Yes	1	3	7
75	R:R:L143	R:R:W141	11.39	No	Yes	0	5	7
76	R:R:C148	R:R:W141	5.22	No	Yes	1	9	7
77	R:R:C227	R:R:W141	9.14	No	Yes	1	9	7
78	R:R:L143	R:R:P144	4.93	No	No	0	5	7
79	R:R:F222	R:R:S145	3.96	Yes	No	0	2	3
80	R:R:L147	R:R:V150	2.98	No	No	0	5	4
81	R:R:C148	R:R:F222	8.38	No	Yes	0	9	2
82	R:R:C148	R:R:C227	5.46	No	No	1	9	9
83	R:R:A149	R:R:L215	3.15	No	No	0	6	5
84	R:R:I152	R:R:W151	3.52	No	Yes	0	5	5
85	R:R:D155	R:R:W151	3.35	Yes	Yes	1	8	5
86	R:R:C227	R:R:W151	3.92	No	Yes	1	9	5
87	R:R:I152	R:R:I210	2.94	No	Yes	0	5	6
88	R:R:I152	R:R:L229	4.28	No	Yes	0	5	4
89	R:R:I210	R:R:Y153	8.46	Yes	No	1	6	6
90	R:R:P211	R:R:Y153	15.3	No	No	1	5	6
91	R:R:F158	R:R:L154	6.09	Yes	No	4	7	5
92	R:R:D155	R:R:S159	2.94	Yes	No	1	8	7
93	R:R:D155	R:R:Y370	10.34	Yes	Yes	1	8	7
94	R:R:S207	R:R:V156	4.85	No	No	1	7	6
95	R:R:I210	R:R:V156	4.61	Yes	No	1	6	6
96	R:R:F158	R:R:L157	4.87	Yes	No	0	7	6
97	R:R:S242	R:R:T160	7.99	No	No	0	6	7
98	R:R:A161	R:R:H165	2.93	No	Yes	3	8	8
99	R:R:A161	R:R:W200	5.19	No	Yes	3	8	9
100	R:R:A161	R:R:S203	3.42	No	No	0	8	8
101	R:R:I163	R:R:P246	3.39	No	Yes	0	8	9
102	R:R:I163	R:R:W336	5.87	No	Yes	0	8	8
103	R:R:M164	R:R:V199	3.04	No	No	0	6	6
104	R:R:I202	R:R:M164	5.83	No	No	0	5	6
105	R:R:M164	R:R:P246	5.03	No	Yes	0	6	9
106	R:R:H165	R:R:V199	8.3	Yes	No	3	8	6
107	R:R:H165	R:R:W200	6.35	Yes	Yes	3	8	9
108	R:R:F332	R:R:L166	3.65	Yes	Yes	1	9	8
109	R:R:L166	R:R:N376	6.87	Yes	No	1	8	9
110	R:R:L166	R:R:Y380	7.03	Yes	Yes	1	8	9
111	R:R:C167	R:R:P246	3.77	No	Yes	0	6	9
112	R:R:C167	R:R:I249	4.91	No	No	0	6	6
113	R:R:C167	R:R:M250	4.86	No	No	0	6	8
114	R:R:A168	R:R:K195	4.82	No	No	0	7	6
115	R:R:I169	R:R:R173	6.26	No	No	1	9	9
116	R:R:I169	R:R:Y380	4.84	No	Yes	1	9	9
117	R:R:M250	R:R:S170	4.6	No	No	0	8	9
118	R:R:S170	R:R:T253	4.8	No	No	0	9	5
119	R:R:I249	R:R:L171	4.28	No	No	0	6	6
120	R:R:L171	R:R:T253	2.95	No	No	0	6	5
121	R:R:D172	R:R:H183	6.3	No	Yes	0	9	7
122	R:R:R173	R:R:Y380	5.14	No	Yes	1	9	9
123	R:R:Q178	R:R:Y174	10.15	No	No	0	6	8
124	R:R:L256	R:R:Y174	8.21	No	No	0	5	8
125	R:R:T257	R:R:Y174	3.75	No	No	0	9	8
126	R:R:H183	R:R:V175	5.54	Yes	No	0	7	5
127	R:R:A176	R:R:H183	8.78	No	Yes	0	8	7
128	R:R:I177	R:R:T257	4.56	No	No	0	9	9
129	R:R:I177	R:R:S260	3.1	No	No	0	9	6
130	R:R:I177	R:R:L261	4.28	No	Yes	0	9	8
131	R:R:N179	R:R:Q178	3.96	Yes	No	0	6	6
132	R:R:Q178	R:R:S260	10.11	No	No	0	6	6
133	R:R:H183	R:R:N187	3.83	Yes	No	0	7	6
134	R:R:F186	R:R:R185	5.34	No	No	0	4	4
135	R:R:K191	R:R:N187	4.2	No	No	0	6	6
136	R:R:S188	R:R:T190	6.4	No	No	0	7	5
137	R:R:F193	R:R:R189	4.28	No	No	0	4	4
138	R:R:G205	R:R:V204	3.68	No	No	0	4	4
139	R:R:I206	R:R:V241	6.14	No	No	0	6	4
140	R:R:I210	R:R:S207	4.64	Yes	No	1	6	7
141	R:R:M208	R:R:P209	3.35	No	No	0	4	7
142	R:R:I210	R:R:P211	3.39	Yes	No	1	6	5
143	R:R:F234	R:R:I210	5.02	No	Yes	0	7	6
144	R:R:F213	R:R:V212	10.49	No	No	0	4	5
145	R:R:G214	R:R:K220	3.49	No	Yes	5	7	3
146	R:R:G214	R:R:V221	3.68	No	No	5	7	3
147	R:R:D217	R:R:S219	5.89	No	No	0	4	3
148	R:R:D217	R:R:K220	4.15	No	Yes	0	4	3
149	R:R:K220	R:R:V221	10.62	Yes	No	5	3	3
150	R:R:D231	R:R:K220	6.91	No	Yes	0	5	3
151	R:R:K223	R:R:L228	9.87	No	No	0	3	4
152	R:R:A230	R:R:K223	6.42	No	No	0	3	3
153	R:R:F234	R:R:L229	7.31	No	Yes	0	7	4
154	R:R:L229	R:R:V235	2.98	Yes	Yes	0	4	6
155	R:R:D231	R:R:N233	4.04	No	No	0	5	3
156	R:R:D231	R:R:F234	5.97	No	No	0	5	7
157	R:R:D232	R:R:V347	10.22	No	No	0	4	5
158	R:R:N343	R:R:V235	4.43	No	Yes	1	7	6
159	R:R:V235	R:R:V347	3.21	Yes	No	0	6	5
160	R:R:G238	R:R:I237	3.53	No	No	0	6	4
161	R:R:F340	R:R:S239	5.28	Yes	No	1	7	6
162	R:R:I344	R:R:S239	4.64	No	No	0	5	6
163	R:R:F240	R:R:I245	7.54	No	No	0	4	5
164	R:R:F243	R:R:F244	5.36	Yes	No	0	8	5
165	R:R:F243	R:R:L247	4.87	Yes	No	0	8	6
166	R:R:F243	R:R:F332	5.36	Yes	Yes	1	8	9
167	R:R:F243	R:R:W336	3.01	Yes	Yes	1	8	8
168	R:R:C337	R:R:F243	5.59	No	Yes	0	6	8
169	R:R:F243	R:R:F340	23.58	Yes	Yes	1	8	7
170	R:R:F244	R:R:I341	3.77	No	No	0	5	6
171	R:R:F244	R:R:I344	5.02	No	No	0	5	5
172	R:R:I245	R:R:P246	3.39	No	Yes	0	5	9
173	R:R:I245	R:R:I249	2.94	No	No	0	5	6
174	R:R:L247	R:R:V251	2.98	No	No	0	6	5
175	R:R:F332	R:R:M250	8.71	Yes	No	0	9	8
176	R:R:I258	R:R:Y254	9.67	No	Yes	0	5	9
177	R:R:G326	R:R:Y254	4.35	No	Yes	0	6	9
178	R:R:F329	R:R:Y254	18.57	Yes	Yes	6	8	9
179	R:R:F330	R:R:Y254	3.09	No	Yes	6	5	9
180	R:R:F255	R:R:L256	3.65	No	No	0	1	5
181	R:R:C322	R:R:I258	3.27	No	No	0	7	5
182	R:R:E318	R:R:L261	3.98	No	Yes	0	8	8
183	R:R:C322	R:R:L261	4.76	No	Yes	0	7	8
184	R:R:N317	R:R:S316	5.96	No	No	0	6	6
185	R:R:I327	R:R:K323	5.82	No	No	0	6	7
186	R:R:F383	R:R:V324	19.66	No	No	0	7	8
187	R:R:V328	R:R:V379	3.21	No	No	0	8	8
188	R:R:V328	R:R:Y380	5.05	No	Yes	0	8	9
189	R:R:F329	R:R:F330	10.72	Yes	No	6	8	5
190	R:R:F329	R:R:V333	5.24	Yes	No	0	8	6
191	R:R:L331	R:R:M335	5.65	No	No	0	6	8
192	R:R:L331	R:R:V375	5.96	No	No	7	6	6
193	R:R:L331	R:R:V379	2.98	No	No	7	6	8
194	R:R:F332	R:R:W336	7.02	Yes	Yes	1	9	8
195	R:R:M335	R:R:S372	6.13	No	No	0	8	9
196	R:R:G369	R:R:W336	4.22	No	Yes	0	7	8
197	R:R:S372	R:R:W336	8.65	No	Yes	0	9	8
198	R:R:F365	R:R:P338	8.67	Yes	No	0	5	9
199	R:R:F339	R:R:F340	7.5	No	Yes	1	7	7
200	R:R:F339	R:R:V366	3.93	No	No	0	7	6
201	R:R:I358	R:R:T342	3.04	No	No	0	4	5
202	R:R:L362	R:R:T342	2.95	No	No	0	3	5
203	R:R:F365	R:R:T342	3.89	Yes	No	0	5	5
204	R:R:I348	R:R:M345	4.37	No	No	0	4	4
205	R:R:C349	R:R:I348	3.27	No	No	0	3	4
206	R:R:L361	R:R:V357	2.98	No	No	0	4	5
207	R:R:G359	R:R:L362	3.42	No	No	0	2	3
208	R:R:F365	R:R:L361	7.31	Yes	No	0	5	4
209	R:R:V366	R:R:Y370	6.31	No	Yes	0	6	7
210	R:R:W367	R:R:Y370	4.82	Yes	Yes	1	6	7
211	R:R:N376	R:R:S372	5.96	No	No	0	9	9
212	R:R:V375	R:R:V379	3.21	No	No	7	6	8
213	R:R:N376	R:R:Y380	4.65	No	Yes	1	9	9
214	R:R:L382	R:R:T381	2.95	No	Yes	0	5	7
215	R:R:T381	R:R:Y387	18.73	Yes	Yes	2	7	8
216	R:R:N384	R:R:T386	4.39	No	No	0	9	6
217	R:R:K385	R:R:R388	8.66	No	No	0	5	9
218	R:R:F213	R:R:P209	2.89	No	No	0	4	7
219	R:R:I252	R:R:L256	2.85	No	No	0	5	5
220	R:R:L101	R:R:M97	2.83	No	No	0	5	4
221	R:R:L228	R:R:L229	2.77	No	Yes	0	4	4
222	R:R:L378	R:R:L382	2.77	No	No	0	6	5
223	R:R:L362	R:R:N343	2.75	No	No	0	3	7
224	R:R:I315	R:R:Q319	2.74	No	No	0	5	5
225	R:R:A98	R:R:Y387	2.67	No	Yes	0	7	8
226	R:R:F329	R:R:V251	2.62	Yes	No	0	8	5
227	R:R:F332	R:R:V333	2.62	Yes	No	0	9	6
228	R:R:F365	R:R:V364	2.62	Yes	No	0	5	4
229	R:R:A119	R:R:W200	2.59	No	Yes	0	8	9
230	R:R:H182	R:R:N179	2.55	No	Yes	0	5	6
231	R:R:I181	R:R:R185	2.51	No	No	0	7	4
232	R:R:F255	R:R:K259	2.48	No	No	0	1	4
233	R:R:L325	R:R:R173	2.43	No	No	0	8	9
234	R:R:L382	R:R:R388	2.43	No	No	0	5	9
235	R:R:A90	R:R:G91	1.95	No	No	0	4	8
236	R:R:A149	R:R:G214	1.95	No	No	0	6	7
237	R:R:G238	R:R:V241	1.84	No	No	0	6	4
238	R:R:A390	R:R:A98	1.79	No	No	0	7	7
239	R:R:A108	R:R:A192	1.79	No	No	0	5	7
240	R:R:P377	R:R:V95	1.77	No	No	0	9	9
241	R:R:G205	R:R:M208	1.75	No	No	0	4	4
242	R:R:G91	R:R:L94	1.71	No	No	0	8	6
243	R:R:G91	R:R:N92	1.7	No	Yes	0	8	9
244	R:R:I85	R:R:P129	1.69	No	No	0	6	8
245	R:R:L147	R:R:P144	1.64	No	No	0	5	7
246	R:R:N179	R:R:P180	1.63	Yes	No	0	6	8
247	R:R:A90	R:R:I86	1.62	No	No	0	4	4
248	R:R:A346	R:R:I358	1.62	No	No	0	4	4
249	R:R:V83	R:R:V84	1.6	No	No	0	4	7
250	R:R:A82	R:R:L79	1.58	No	No	0	3	4
251	R:R:A321	R:R:L261	1.58	No	Yes	0	8	8
252	R:R:A108	R:R:N107	1.56	No	No	0	5	7
253	R:R:A108	R:R:N187	1.56	No	No	0	5	6
254	R:R:I96	R:R:S100	1.55	Yes	No	0	6	1
255	R:R:I197	R:R:T201	1.52	No	No	0	2	4
256	R:R:K320	R:R:V324	1.52	No	No	0	8	8
257	R:R:M335	R:R:V334	1.52	No	No	0	8	5
258	R:R:F222	R:R:G225	1.51	Yes	No	0	2	3
259	R:R:L80	R:R:V83	1.49	No	No	0	4	4
260	R:R:L157	R:R:V204	1.49	No	No	0	6	4
261	R:R:L236	R:R:V347	1.49	No	No	0	6	5
262	R:R:N179	R:R:V175	1.48	Yes	No	0	6	5
263	R:R:I86	R:R:I89	1.47	No	No	0	4	5
264	R:R:I93	R:R:M97	1.46	No	No	0	3	4
265	R:R:N110	R:R:T109	1.46	No	No	0	9	8
266	R:R:G138	R:R:Y139	1.45	No	Yes	0	5	3
267	R:R:E318	R:R:S314	1.44	No	No	0	8	5
268	R:R:Q106	R:R:V99	1.43	No	No	0	7	7
269	R:R:H183	R:R:S184	1.39	Yes	No	0	7	6
270	R:R:E318	R:R:I315	1.37	No	No	0	8	5
271	R:R:K259	R:R:Q262	1.36	No	No	0	4	6
272	R:R:N317	R:R:Q313	1.32	No	No	0	6	5
273	R:R:F383	R:R:V328	1.31	No	No	0	7	8
274	R:R:S226	R:R:Y139	1.27	No	Yes	0	4	3
275	R:R:F365	R:R:I368	1.26	Yes	No	0	5	7
276	R:R:F186	R:R:K191	1.24	No	No	0	4	6
277	R:R:D218	R:R:F222	1.19	No	Yes	0	3	2
278	R:R:L136	R:R:Y137	1.17	No	Yes	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.327	10	1	0
2	R:R:N92	5.314	5	0	9
3	R:R:I96	3.0275	4	0	6
4	R:R:L105	8.1975	4	2	8
5	R:R:D120	6.045	4	0	9
6	R:R:V127	3.7075	4	1	8
7	R:R:M128	4.614	5	1	8
8	R:R:Y137	8.78	4	1	4
9	R:R:Y139	5.46	4	0	3
10	R:R:W141	7.7875	4	1	7
11	R:R:W151	4.61	5	1	5
12	R:R:D155	6.048	5	1	8
13	R:R:F158	6.088	5	4	7
14	R:R:H165	7.12667	6	3	8
15	R:R:L166	5.425	4	1	8
16	R:R:N179	2.405	4	0	6
17	R:R:H183	5.168	5	0	7
18	R:R:W200	4.46	4	3	9
19	R:R:I210	4.84333	6	1	6
20	R:R:K220	6.2925	4	5	3
21	R:R:F222	3.76	4	0	2
22	R:R:L229	4.335	4	0	4
23	R:R:V235	3.605	4	1	6
24	R:R:F243	7.96167	6	1	8
25	R:R:P246	3.895	4	0	9
26	R:R:Y254	8.92	4	6	9
27	R:R:L261	3.65	4	0	8
28	R:R:F329	9.2875	4	6	8
29	R:R:F332	5.472	5	1	9
30	R:R:W336	5.754	5	1	8
31	R:R:F340	12.1975	4	1	7
32	R:R:F365	4.75	5	0	5
33	R:R:W367	7.738	5	1	6
34	R:R:Y370	6.728	5	1	7
35	R:R:Y380	5.342	5	1	9
36	R:R:T381	7.715	4	2	7
37	R:R:Y387	7.9	6	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D155	54.8687	9.23	Yes	Yes	1	0	8
2	R:R:D155	R:R:Y370	30.3844	10.34	Yes	Yes	1	8	7
3	R:R:W367	R:R:Y370	36.2242	4.82	Yes	Yes	1	6	7
4	R:R:T81	R:R:W367	12.577	16.98	No	Yes	0	6	6
5	R:R:M128	R:R:Y370	25.1741	8.38	Yes	Yes	1	8	7
6	R:R:M128	R:R:V84	13.0123	3.04	Yes	No	0	8	7
7	R:R:D155	R:R:V127	12.6909	4.38	Yes	Yes	1	8	8
8	R:R:L123	R:R:V127	46.6582	2.98	No	Yes	0	7	8
9	R:R:L123	R:R:S373	47.7833	3	No	No	0	7	9
10	R:R:D120	R:R:S373	47.9105	8.83	Yes	No	0	9	9
11	R:R:D120	R:R:N92	55.6925	5.39	Yes	Yes	0	9	9
12	R:R:G91	R:R:N92	14.5192	1.7	No	Yes	0	8	9
13	R:R:A90	R:R:G91	11.3849	1.95	No	No	0	4	8
14	R:R:N92	R:R:P377	38.4409	8.15	Yes	No	0	9	9
15	R:R:P377	R:R:V95	37.1082	1.77	No	No	0	9	9
16	R:R:T381	R:R:V95	35.7353	4.76	Yes	No	0	7	9
17	R:R:T381	R:R:Y387	27.498	18.73	Yes	Yes	2	7	8
18	R:R:V99	R:R:Y387	12.9119	3.79	No	Yes	0	7	8
19	L:L:?1	R:R:F340	80.371	12.43	Yes	Yes	1	0	7
20	R:R:F243	R:R:F340	100	23.58	Yes	Yes	1	8	7
21	R:R:F243	R:R:F332	56.0876	5.36	Yes	Yes	1	8	9
22	R:R:F332	R:R:L166	43.7383	3.65	Yes	Yes	1	9	8
23	R:R:L116	R:R:L166	40.8787	4.15	No	Yes	0	9	8
24	R:R:H165	R:R:L116	21.243	10.29	Yes	No	0	8	9
25	R:R:F243	R:R:W336	13.4543	3.01	Yes	Yes	1	8	8
26	R:R:F158	R:R:L123	17.7471	6.09	Yes	No	0	7	7
27	R:R:D155	R:R:W151	25.0268	3.35	Yes	Yes	1	8	5
28	R:R:C227	R:R:W151	32.9896	3.92	No	Yes	1	9	5
29	R:R:C227	R:R:W141	20.8211	9.14	No	Yes	1	9	7
30	R:R:P142	R:R:W141	10.742	5.4	No	Yes	1	3	7
31	R:R:I135	R:R:W367	18.5842	3.52	No	Yes	0	5	6
32	R:R:I135	R:R:N363	15.7983	5.66	No	No	0	5	4
33	R:R:N363	R:R:Y139	13.0056	11.63	No	Yes	0	4	3
34	R:R:C148	R:R:C227	10.4072	5.46	No	No	1	9	9
35	L:L:?1	R:R:V156	18.6579	11.4	Yes	No	1	0	6
36	R:R:I210	R:R:V156	15.5371	4.61	Yes	No	1	6	6
37	R:R:F234	R:R:I210	20.1313	5.02	No	Yes	0	7	6
38	R:R:D231	R:R:F234	37.3627	5.97	No	No	0	5	7
39	R:R:D231	R:R:K220	29.1522	6.91	No	Yes	0	5	3
40	R:R:G214	R:R:K220	12.5502	3.49	No	Yes	5	7	3
41	L:L:?1	R:R:V235	22.4618	3.8	Yes	Yes	1	0	6
42	R:R:L229	R:R:V235	18.4302	2.98	Yes	Yes	0	4	6
43	R:R:F234	R:R:L229	21.2831	7.31	No	Yes	0	7	4
44	R:R:I152	R:R:W151	25.7166	3.52	No	Yes	0	5	5
45	R:R:I152	R:R:I210	12.577	2.94	No	Yes	0	5	6
46	R:R:F158	R:R:L157	11.4787	4.87	Yes	No	0	7	6
47	R:R:L166	R:R:Y380	18.457	7.03	Yes	Yes	1	8	9
48	R:R:F332	R:R:M250	13.7155	8.71	Yes	No	0	9	8
49	R:R:F243	R:R:L247	34.6504	4.87	Yes	No	0	8	6
50	R:R:L247	R:R:V251	33.378	2.98	No	No	0	6	5
51	R:R:F329	R:R:V251	32.581	2.62	Yes	No	0	8	5
52	R:R:F329	R:R:Y254	86.4653	18.57	Yes	Yes	6	8	9
53	R:R:I258	R:R:Y254	82.427	9.67	No	Yes	0	5	9
54	R:R:C322	R:R:I258	80.1768	3.27	No	No	0	7	5
55	R:R:C322	R:R:L261	78.2347	4.76	No	Yes	0	7	8
56	R:R:I177	R:R:L261	64.3852	4.28	No	Yes	0	9	8
57	R:R:I177	R:R:S260	44.7361	3.1	No	No	0	9	6
58	R:R:Q178	R:R:S260	42.3587	10.11	No	No	0	6	6
59	R:R:N179	R:R:Q178	40.6443	3.96	Yes	No	0	6	6
60	R:R:N179	R:R:V175	33.1503	1.48	Yes	No	0	6	5
61	R:R:H183	R:R:V175	30.6255	5.54	Yes	No	0	7	5
62	R:R:F332	R:R:V333	60.7085	2.62	Yes	No	0	9	6
63	R:R:F329	R:R:V333	59.4026	5.24	Yes	No	0	8	6
64	R:R:I177	R:R:T257	17.6668	4.56	No	No	0	9	9
65	R:R:T257	R:R:Y174	15.296	3.75	No	No	0	9	8
66	R:R:L256	R:R:Y174	13.2869	8.21	No	No	0	5	8
67	R:R:H183	R:R:N187	20.3791	3.83	Yes	No	0	7	6
68	R:R:K191	R:R:N187	10.2799	4.2	No	No	0	6	6
69	R:R:E318	R:R:L261	10.6215	3.98	No	Yes	0	8	8
70	R:R:V328	R:R:Y380	11.4586	5.05	No	Yes	0	8	9
71	L:L:?1	R:R:N343	19.4616	3.5	Yes	No	1	0	7
72	R:R:L362	R:R:N343	19.3544	2.75	No	No	0	3	7
73	R:R:L362	R:R:T342	16.1264	2.95	No	No	0	3	5
74	R:R:F365	R:R:T342	10.8559	3.89	Yes	No	0	5	5
75	R:R:F339	R:R:V366	17.9681	3.93	No	No	0	7	6
76	R:R:D120	R:R:L116	43.0418	4.07	Yes	No	0	9	9
77	R:R:I152	R:R:L229	13.4208	4.28	No	Yes	0	5	4
78	R:R:V366	R:R:Y370	17.5663	6.31	No	Yes	0	6	7
79	R:R:F339	R:R:F340	18.2494	7.5	No	Yes	1	7	7
80	R:R:V127	R:R:Y370	18.4637	3.79	Yes	Yes	1	8	7
81	R:R:V127	R:R:W151	29.1187	3.68	Yes	Yes	1	8	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D155	9.23	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:V156	11.4	1	Yes	No	0	6	0	1
L:L:?1	R:R:S159	8.94	1	Yes	No	0	7	0	1
L:L:?1	R:R:V235	3.8	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:G238	2.91	1	Yes	No	0	6	0	1
L:L:?1	R:R:S239	3.83	1	Yes	No	0	6	0	1
L:L:?1	R:R:S242	8.94	1	Yes	No	0	6	0	1
L:L:?1	R:R:F339	8.29	1	Yes	No	0	7	0	1
L:L:?1	R:R:F340	12.43	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N343	3.5	1	Yes	No	0	7	0	1
R:R:V127	R:R:W151	3.68	1	Yes	Yes	8	5	2	2
R:R:D155	R:R:V127	4.38	1	Yes	Yes	8	8	1	2
R:R:V127	R:R:Y370	3.79	1	Yes	Yes	8	7	2	2
R:R:D155	R:R:W151	3.35	1	Yes	Yes	8	5	1	2
R:R:D155	R:R:S159	2.94	1	Yes	No	8	7	1	1
R:R:D155	R:R:Y370	10.34	1	Yes	Yes	8	7	1	2
R:R:S207	R:R:V156	4.85	1	No	No	7	6	2	1
R:R:I210	R:R:V156	4.61	1	Yes	No	6	6	2	1
R:R:S242	R:R:T160	7.99	0	No	No	6	7	1	2
R:R:I210	R:R:S207	4.64	1	Yes	No	6	7	2	2
R:R:L229	R:R:V235	2.98	0	Yes	Yes	4	6	2	1
R:R:N343	R:R:V235	4.43	1	No	Yes	7	6	1	1
R:R:V235	R:R:V347	3.21	1	Yes	No	6	5	1	2
R:R:G238	R:R:I237	3.53	0	No	No	6	4	1	2
R:R:F340	R:R:S239	5.28	1	Yes	No	7	6	1	1
R:R:I344	R:R:S239	4.64	0	No	No	5	6	2	1
R:R:F243	R:R:F340	23.58	1	Yes	Yes	8	7	2	1
R:R:F339	R:R:F340	7.5	1	No	Yes	7	7	1	1
R:R:F339	R:R:V366	3.93	1	No	No	7	6	1	2
R:R:V366	R:R:Y370	6.31	0	No	Yes	6	7	2	2
R:R:L362	R:R:N343	2.75	0	No	No	3	7	2	1
R:R:G238	R:R:V241	1.84	0	No	No	6	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9ARY_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.91
Number of Linked Nodes	247
Number of Links	278
Number of Hubs	37
Number of Links mediated by Hubs	151
Number of Communities	7
Number of Nodes involved in Communities	57
Number of Links involved in Communities	74

Path Summary
Number Of Nodes in MetaPath	82
Number Of Links MetaPath	81
Number of Shortest Paths	38928
Length Of Smallest Path	3
Average Path Length	12.918
Length of Longest Path	31
Minimum Path Strength	1.35
Average Path Strength	6.34788
Maximum Path Strength	18.005
Minimum Path Correlation	0.7
Average Path Correlation	0.92038
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	44.6364
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.2263
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein tyrosine kinase activator activity • enzyme regulator activity • kinase activator activity • enzyme activator activity • molecular function activator activity • molecular function regulator activity • protein kinase activator activity • protein kinase regulator activity • kinase regulator activity • neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • serotonin receptor activity • transmembrane signaling receptor activity • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • G protein-coupled receptor activity • Gq/11-coupled serotonin receptor activity • protein-containing complex binding • binding • identical protein binding • protein binding • cation binding • ion binding • serotonin binding • amine binding • heterocyclic compound binding • small molecule binding • virus receptor activity • exogenous protein binding • 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding • response to stimulus • response to chemical • response to xenobiotic stimulus • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process
Gene Ontology	Biological Process	• response to stimulus • response to chemical • response to xenobiotic stimulus • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • trans-synaptic signaling • regulation of signaling • modulation of chemical synaptic transmission • cell-cell signaling • presynaptic modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • regulation of cell communication • regulation of defense response • regulation of response to external stimulus • defense response • positive regulation of biological process • response to external stimulus • regulation of inflammatory response • positive regulation of response to stimulus • positive regulation of response to external stimulus • positive regulation of inflammatory response • regulation of response to stimulus • regulation of response to stress • response to stress • positive regulation of defense response • inflammatory response • regulation of tube diameter • multicellular organismal process • system process • regulation of tube size • regulation of system process • positive regulation of vasoconstriction • circulatory system process • regulation of blood circulation • vascular process in circulatory system • regulation of vasoconstriction • positive regulation of multicellular organismal process • regulation of multicellular organismal process • blood vessel diameter maintenance • regulation of biological quality • vasoconstriction • blood circulation • regulation of anatomical structure size • localization • protein localization to cytoskeleton • protein localization to organelle • macromolecule localization • intracellular protein localization • regulation of lipid metabolic process • glycerophospholipid metabolic process • lipid biosynthetic process • positive regulation of phosphate metabolic process • regulation of primary metabolic process • phospholipid metabolic process • positive regulation of metabolic process • positive regulation of biosynthetic process • phosphate-containing compound metabolic process • positive regulation of lipid metabolic process • positive regulation of phosphatidylinositol biosynthetic process • phosphorus metabolic process • positive regulation of cellular process • regulation of phosphatidylinositol biosynthetic process • regulation of biosynthetic process • phosphatidylinositol metabolic process • positive regulation of phosphorus metabolic process • glycerophospholipid biosynthetic process • positive regulation of phospholipid biosynthetic process • regulation of phospholipid metabolic process • primary metabolic process • phospholipid biosynthetic process • regulation of phospholipid biosynthetic process • phosphatidylinositol biosynthetic process • positive regulation of phospholipid metabolic process • biosynthetic process • positive regulation of lipid biosynthetic process • glycerolipid biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • metabolic process • regulation of phosphorus metabolic process • glycerolipid metabolic process • regulation of lipid biosynthetic process • regulation of metabolic process • lipid metabolic process • neuron apoptotic process • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • apoptotic process • positive regulation of neuron apoptotic process • programmed cell death • regulation of neuron apoptotic process • behavior • learning or memory • nervous system process • cognition • memory • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • regulation of execution phase of apoptosis • positive regulation of execution phase of apoptosis • execution phase of apoptosis • regulation of body fluid levels • homotypic cell-cell adhesion • regulation of cell activation • positive regulation of cell-cell adhesion • cell adhesion • cell-cell adhesion • coagulation • regulation of cell-cell adhesion • response to wounding • wound healing • regulation of homotypic cell-cell adhesion • positive regulation of cell adhesion • regulation of cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • regulation of platelet activation • regulation of platelet aggregation • positive regulation of homotypic cell-cell adhesion • positive regulation of platelet aggregation • platelet activation • ribonucleotide catabolic process • pyridine nucleotide catabolic process • aerobic respiration • oxoacid metabolic process • carbohydrate catabolic process • carbohydrate derivative metabolic process • organophosphate catabolic process • nucleoside phosphate catabolic process • organic acid metabolic process • nucleobase-containing compound metabolic process • glycolytic process • pyridine-containing compound metabolic process • small molecule metabolic process • purine ribonucleotide catabolic process • nucleoside phosphate metabolic process • nicotinamide nucleotide metabolic process • pyruvate metabolic process • purine nucleoside diphosphate metabolic process • purine-containing compound catabolic process • nucleotide metabolic process • nucleobase-containing compound catabolic process • nucleoside diphosphate metabolic process • purine nucleoside diphosphate catabolic process • nucleoside diphosphate catabolic process • nucleoside triphosphate metabolic process • monocarboxylic acid metabolic process • purine ribonucleotide metabolic process • pyridine-containing compound catabolic process • ribose phosphate metabolic process • cellular respiration • catabolic process • ATP metabolic process • energy derivation by oxidation of organic compounds • purine nucleotide metabolic process • ribonucleotide metabolic process • nucleobase-containing small molecule metabolic process • purine ribonucleoside triphosphate metabolic process • ribonucleoside diphosphate metabolic process • ribonucleoside diphosphate catabolic process • nucleotide catabolic process • purine nucleoside triphosphate metabolic process • purine nucleotide catabolic process • carbohydrate metabolic process • carbohydrate derivative catabolic process • ADP catabolic process • carboxylic acid metabolic process • generation of precursor metabolites and energy • purine-containing compound metabolic process • ADP metabolic process • purine ribonucleoside diphosphate metabolic process • purine ribonucleoside diphosphate catabolic process • detection of external stimulus • detection of stimulus involved in sensory perception of pain • sensory perception of temperature stimulus • sensory perception of pain • detection of temperature stimulus involved in sensory perception • response to temperature stimulus • detection of abiotic stimulus • detection of stimulus • sensory perception • detection of temperature stimulus • response to abiotic stimulus • detection of stimulus involved in sensory perception • detection of temperature stimulus involved in sensory perception of pain • negative regulation of signaling • synaptic transmission, glutamatergic • negative regulation of biological process • regulation of synaptic transmission, glutamatergic • negative regulation of synaptic transmission • negative regulation of cell communication • negative regulation of cellular process • negative regulation of synaptic transmission, glutamatergic • smooth muscle contraction • urinary bladder smooth muscle contraction • urinary tract smooth muscle contraction • muscle contraction • muscle system process • developmental process • fat cell differentiation • positive regulation of fat cell differentiation • regulation of developmental process • cellular developmental process • regulation of cell differentiation • positive regulation of developmental process • positive regulation of cell differentiation • cell differentiation • regulation of fat cell differentiation • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • negative regulation of potassium ion transport • regulation of localization • regulation of potassium ion transport • transport • regulation of transport • negative regulation of monoatomic ion transport • regulation of monoatomic ion transport • negative regulation of transport • establishment of localization • metal ion transport • monoatomic ion transport • potassium ion transport • monoatomic cation transport • regulation of metal ion transport • positive regulation of cytosolic calcium ion concentration • regulation of heat generation • positive regulation of heat generation • heat generation • multicellular organismal-level homeostasis • temperature homeostasis • regulation of generation of precursor metabolites and energy • regulation of ATP metabolic process • regulation of purine nucleotide catabolic process • positive regulation of nucleotide catabolic process • regulation of small molecule metabolic process • regulation of nucleotide metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of carbohydrate catabolic process • regulation of purine nucleotide metabolic process • positive regulation of ATP metabolic process • regulation of nucleotide catabolic process • positive regulation of carbohydrate metabolic process • positive regulation of nucleotide metabolic process • positive regulation of purine nucleotide catabolic process • regulation of carbohydrate metabolic process • positive regulation of glycolytic process • regulation of catabolic process • regulation of glycolytic process • positive regulation of purine nucleotide metabolic process • positive regulation of catabolic process • positive regulation of small molecule metabolic process • adult behavior • behavioral response to cocaine • response to oxygen-containing compound • response to nitrogen compound • response to cocaine • response to alkaloid • detection of mechanical stimulus involved in sensory perception of pain • response to mechanical stimulus • detection of mechanical stimulus involved in sensory perception • sensory perception of mechanical stimulus • detection of mechanical stimulus • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • learning • nonassociative learning • sensitization • monoamine transport • nitrogen compound transport • regulation of catecholamine secretion • organic hydroxy compound transport • dopamine transport • secretion by cell • regulation of secretion by cell • catecholamine transport • signal release • secretion • export from cell • dopamine secretion • regulation of secretion • catecholamine secretion • amine transport • regulation of amine transport • regulation of dopamine secretion • cellular response to nitrogen compound • response to dopamine • serotonin receptor signaling pathway • cellular response to dopamine • response to monoamine • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to catecholamine • cellular response to monoamine stimulus • cellular response to catecholamine stimulus • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • cellular localization • monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • calcium ion transport • maintenance of location in cell • monoatomic cation transmembrane transport • regulation of sequestering of calcium ion • calcium ion transmembrane import into cytosol • sequestering of calcium ion • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • calcium ion transmembrane transport • vascular associated smooth muscle contraction • artery smooth muscle contraction • tonic smooth muscle contraction • regulation of DNA biosynthetic process • positive regulation of macromolecule biosynthetic process • nucleic acid biosynthetic process • positive regulation of macromolecule metabolic process • positive regulation of DNA biosynthetic process • regulation of macromolecule metabolic process • DNA metabolic process • nucleobase-containing compound biosynthetic process • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of DNA metabolic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • DNA biosynthetic process • regulation of DNA metabolic process • regulation of immune effector process • cytokine production • regulation of cytokine production • positive regulation of immune effector process • regulation of immune system process • cytokine production involved in immune response • positive regulation of immune system process • production of molecular mediator of immune response • regulation of cytokine production involved in immune response • immune response • gene expression • immune effector process • regulation of gene expression • positive regulation of gene expression • immune system process • positive regulation of cytokine production involved in immune response • positive regulation of production of molecular mediator of immune response • regulation of production of molecular mediator of immune response • positive regulation of cytokine production • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • G protein-coupled serotonin receptor complex • receptor complex • presynapse
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • G protein-coupled serotonin receptor complex • receptor complex • presynapse • presynaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • glutamatergic synapse • dendritic shaft • cell body • neuronal cell body • axon • membrane microdomain • membrane raft • plasma membrane raft • caveola • cell body fiber • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • cytoplasmic vesicle • organelle • intracellular vesicle • cytoplasm • intracellular membrane-bounded organelle • vesicle • polymeric cytoskeletal fiber • neurofilament • intracellular membraneless organelle • intermediate filament cytoskeleton • cytoskeleton • membraneless organelle • intermediate filament • supramolecular fiber • supramolecular polymer • supramolecular complex • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	SRO
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	SRO
Name	Serotonin
Synonyms	thrombotonin
Identifier
Formula	C10 H12 N2 O
Molecular Weight	176.215
SMILES
PubChem	5202
Formal Charge	0
Total Atoms	25
Total Chiral Atoms	0
Total Bonds	26
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P28223
Sequence	>9ARY_nogp_Chain_R L L T A V V I I L T I A G N I L V I M A V S L E K K L Q N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G Y R W P L P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N P I H H S R F N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D S K V F K E G S C L L A D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T Y R S A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6WGT	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WH4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WHA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.36	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WHA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-		3.36	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	8ZMG	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Pimavanserin	-	-	3.4	2024-08-28	doi.org/10.1021/acs.jmedchem.4c01244
	7RAN	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.45	2022-07-06	doi.org/10.1038/s41586-022-05258-z
	7RAN (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-		3.45	2022-07-06	doi.org/10.1038/s41586-022-05258-z
	7VOD	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Cariprazine	-	-	3.3	2021-12-22	doi.org/10.1038/s41593-021-00971-w
	7VOE	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Aripiprazole	-	-	2.9	2021-12-22	doi.org/10.1038/s41593-021-00971-w
	6A93	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Risperidone	-	-	3	2019-02-13	doi.org/10.1038/s41594-018-0180-z
	6A94	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Zotepine	-	-	2.9	2019-02-13	doi.org/10.1038/s41594-018-0180-z
	7WC4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	-	3.2	2022-01-26	doi.org/10.1126/science.abl8615
	7WC5	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	-	3.2	2022-01-26	doi.org/10.1126/science.abl8615
	7WC6	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	2.6	2022-01-26	doi.org/10.1126/science.abl8615
	7WC7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	-	2.6	2022-01-26	doi.org/10.1126/science.abl8615
	7WC8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lumateperone	-	-	2.45	2022-01-26	doi.org/10.1126/science.abl8615
	7WC9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 162421364	-	-	2.5	2022-01-26	doi.org/10.1126/science.abl8615
	8UWL	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.8	2024-05-29	doi.org/10.1126/science.adn6354
	8UWL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-		2.8	2024-05-29	doi.org/10.1126/science.adn6354
	8V6U	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 171392456	-	chim(NtGi2-Gs-CtGq)/β1/γ2	3	2024-05-29	doi.org/10.1126/science.adn6354
	8V6U (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 171392456	-		3	2024-05-29	doi.org/10.1126/science.adn6354
	8JT8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	(R)-IHCH-7179	-	-	2.7	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	9ARX	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	-	3.24	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARY	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.27	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARY (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-		3.27	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARZ	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-	-	3.37	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS0	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS0 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-		3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS1	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-	-	3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS2	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.21	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-		3.21	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS3	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.18	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.06	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS4 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-		3.06	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS5	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-	-	3.34	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS6	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-		3.07	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	-	2.72	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-	-	3.47	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ASA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.12	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ASA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-		3.12	2025-04-02	doi.org/10.1038/s41467-025-57956-7

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