psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D155	8.9	Yes	Yes	1	0	8
2	L:L:?1	R:R:V156	4.88	Yes	No	0	0	6
3	L:L:?1	R:R:S159	9.84	Yes	No	1	0	7
4	L:L:?1	R:R:S242	3.28	Yes	No	1	0	6
5	L:L:?1	R:R:W336	4.98	Yes	Yes	1	0	8
6	L:L:?1	R:R:F339	9.98	Yes	Yes	1	0	7
7	L:L:?1	R:R:F340	9.98	Yes	Yes	1	0	7
8	L:L:?1	R:R:G369	4.67	Yes	No	0	0	7
9	L:L:?1	R:R:Y370	8.97	Yes	Yes	1	0	7
10	R:R:V84	R:R:W367	4.9	No	Yes	0	7	6
11	R:R:L371	R:R:V84	7.45	No	No	0	4	7
12	R:R:I85	R:R:M128	5.83	No	Yes	0	6	8
13	R:R:M128	R:R:T88	9.03	Yes	No	0	8	7
14	R:R:S373	R:R:T88	3.2	No	No	0	9	7
15	R:R:A374	R:R:T88	3.36	No	No	0	6	7
16	R:R:I89	R:R:I93	2.94	No	No	0	5	3
17	R:R:G91	R:R:P377	4.06	No	No	0	8	9
18	R:R:I93	R:R:N92	8.5	No	Yes	1	3	9
19	R:R:I96	R:R:N92	2.83	No	Yes	0	6	9
20	R:R:A117	R:R:N92	3.13	No	Yes	0	9	9
21	R:R:M121	R:R:N92	14.02	No	Yes	1	7	9
22	R:R:I93	R:R:M121	4.37	No	No	1	3	7
23	R:R:F391	R:R:L94	13.4	No	No	0	6	6
24	R:R:A117	R:R:V95	3.39	No	Yes	0	9	9
25	R:R:P377	R:R:V95	3.53	No	Yes	0	9	9
26	R:R:V95	R:R:Y380	3.79	Yes	Yes	0	9	9
27	R:R:F391	R:R:V95	5.24	No	Yes	0	6	9
28	R:R:I96	R:R:M114	4.37	No	No	0	6	5
29	R:R:I118	R:R:I96	4.42	No	No	0	6	6
30	R:R:M97	R:R:Y394	4.79	No	Yes	0	4	4
31	R:R:A98	R:R:Y387	2.67	No	Yes	0	7	8
32	R:R:N110	R:R:V99	2.96	Yes	No	3	9	7
33	R:R:M114	R:R:V99	6.09	No	No	0	5	7
34	R:R:V99	R:R:Y387	3.79	No	Yes	3	7	8
35	R:R:L101	R:R:Y394	12.89	No	Yes	0	5	4
36	R:R:E102	R:R:K104	9.45	No	No	3	6	6
37	R:R:E102	R:R:T386	4.23	No	Yes	3	6	6
38	R:R:K103	R:R:Q106	9.49	No	No	0	6	7
39	R:R:K104	R:R:L105	12.69	No	Yes	3	6	8
40	R:R:K104	R:R:T386	10.51	No	Yes	3	6	6
41	R:R:L105	R:R:N110	10.98	Yes	Yes	3	8	9
42	R:R:L105	R:R:T386	2.95	Yes	Yes	3	8	6
43	R:R:L105	R:R:Y387	5.86	Yes	Yes	3	8	8
44	R:R:Q106	R:R:Y111	11.27	No	No	0	7	4
45	R:R:N107	R:R:T109	2.92	No	No	0	7	8
46	R:R:N107	R:R:N110	12.26	No	Yes	0	7	9
47	R:R:A108	R:R:R189	2.77	No	No	0	5	4
48	R:R:L113	R:R:T109	2.95	No	No	0	8	8
49	R:R:N110	R:R:Y387	10.47	Yes	Yes	3	9	8
50	R:R:M114	R:R:Y111	5.99	No	No	0	5	4
51	R:R:R189	R:R:Y111	7.2	No	No	0	4	4
52	R:R:F112	R:R:I196	16.33	No	No	0	8	8
53	R:R:I169	R:R:L113	2.85	No	No	0	9	8
54	R:R:L113	R:R:Y380	14.07	No	Yes	0	8	9
55	R:R:H165	R:R:S115	2.79	Yes	No	0	8	9
56	R:R:I196	R:R:S115	3.1	No	No	0	8	9
57	R:R:D120	R:R:L116	5.43	No	Yes	0	9	9
58	R:R:H165	R:R:L116	6.43	Yes	Yes	0	8	9
59	R:R:L116	R:R:L166	4.15	Yes	No	1	9	8
60	R:R:L116	R:R:N376	6.87	Yes	Yes	1	9	9
61	R:R:D120	R:R:S162	5.89	No	No	0	9	9
62	R:R:D120	R:R:S373	7.36	No	No	0	9	9
63	R:R:L122	R:R:M121	4.24	No	No	1	7	7
64	R:R:L122	R:R:L126	2.77	No	Yes	1	7	5
65	R:R:F158	R:R:L122	10.96	Yes	No	1	7	7
66	R:R:G124	R:R:L123	3.42	No	Yes	1	6	7
67	R:R:L123	R:R:M128	2.83	Yes	Yes	1	7	8
68	R:R:D155	R:R:L123	4.07	Yes	Yes	1	8	7
69	R:R:F158	R:R:L123	4.87	Yes	Yes	1	7	7
70	R:R:L123	R:R:S159	4.5	Yes	No	1	7	7
71	R:R:L123	R:R:S373	3	Yes	No	0	7	9
72	R:R:G124	R:R:M128	5.24	No	Yes	1	6	8
73	R:R:F125	R:R:L126	3.65	No	Yes	0	4	5
74	R:R:L126	R:R:L154	2.77	Yes	No	0	5	5
75	R:R:F158	R:R:L126	3.65	Yes	Yes	1	7	5
76	R:R:V127	R:R:W151	6.13	No	Yes	0	8	5
77	R:R:D155	R:R:V127	8.76	Yes	No	0	8	8
78	R:R:M128	R:R:Y370	15.57	Yes	Yes	1	8	7
79	R:R:V130	R:R:W141	3.68	No	Yes	2	4	7
80	R:R:L143	R:R:V130	2.98	No	No	2	5	4
81	R:R:V130	R:R:W151	13.48	No	Yes	2	4	5
82	R:R:M132	R:R:W367	4.65	No	Yes	0	6	6
83	R:R:I135	R:R:Y139	8.46	No	No	0	5	3
84	R:R:I135	R:R:W367	4.7	No	Yes	0	5	6
85	R:R:P142	R:R:Y137	5.56	No	No	0	3	4
86	R:R:N363	R:R:Y139	18.61	No	No	0	4	3
87	R:R:L143	R:R:W141	14.81	No	Yes	2	5	7
88	R:R:C148	R:R:W141	7.84	No	Yes	2	9	7
89	R:R:W141	R:R:W151	14.99	Yes	Yes	2	7	5
90	R:R:F222	R:R:W141	5.01	Yes	Yes	2	2	7
91	R:R:C227	R:R:W141	13.06	No	Yes	2	9	7
92	R:R:L143	R:R:P144	4.93	No	No	0	5	7
93	R:R:D218	R:R:S145	5.89	No	No	0	3	3
94	R:R:K146	R:R:L215	7.05	No	Yes	0	1	5
95	R:R:L147	R:R:V150	2.98	No	No	0	5	4
96	R:R:C148	R:R:F222	8.38	No	Yes	2	9	2
97	R:R:C148	R:R:C227	7.28	No	No	2	9	9
98	R:R:A149	R:R:L215	4.73	No	Yes	0	6	5
99	R:R:L215	R:R:V150	2.98	Yes	No	0	5	4
100	R:R:I152	R:R:I210	2.94	No	Yes	2	5	6
101	R:R:C227	R:R:I152	3.27	No	No	2	9	5
102	R:R:I152	R:R:L229	2.85	No	No	2	5	4
103	R:R:L157	R:R:Y153	5.86	Yes	No	1	6	6
104	R:R:S207	R:R:Y153	7.63	No	No	1	7	6
105	R:R:P211	R:R:Y153	19.47	No	No	0	5	6
106	R:R:D155	R:R:S159	2.94	Yes	No	1	8	7
107	R:R:D155	R:R:Y370	10.34	Yes	Yes	1	8	7
108	R:R:S207	R:R:V156	3.23	No	No	0	7	6
109	R:R:I210	R:R:V156	4.61	Yes	No	0	6	6
110	R:R:F158	R:R:L157	4.87	Yes	Yes	1	7	6
111	R:R:L157	R:R:S203	6.01	Yes	No	0	6	8
112	R:R:L157	R:R:V204	2.98	Yes	No	0	6	4
113	R:R:L157	R:R:S207	6.01	Yes	No	1	6	7
114	R:R:M164	R:R:T160	3.01	Yes	No	0	6	7
115	R:R:I206	R:R:T160	3.04	No	No	1	6	7
116	R:R:S242	R:R:T160	7.99	No	No	1	6	7
117	R:R:A161	R:R:W200	6.48	No	No	0	8	9
118	R:R:A161	R:R:S203	3.42	No	No	0	8	8
119	R:R:F243	R:R:I163	5.02	Yes	No	1	8	8
120	R:R:I163	R:R:P246	3.39	No	Yes	0	8	9
121	R:R:I163	R:R:W336	10.57	No	Yes	1	8	8
122	R:R:M164	R:R:V199	3.04	Yes	No	0	6	6
123	R:R:I202	R:R:M164	5.83	No	Yes	0	5	6
124	R:R:M164	R:R:P246	3.35	Yes	Yes	0	6	9
125	R:R:H165	R:R:V199	8.3	Yes	No	0	8	6
126	R:R:H165	R:R:W200	7.41	Yes	No	0	8	9
127	R:R:L166	R:R:W336	4.56	No	Yes	1	8	8
128	R:R:L166	R:R:N376	2.75	No	Yes	1	8	9
129	R:R:C167	R:R:P246	3.77	No	Yes	0	6	9
130	R:R:C167	R:R:I249	4.91	No	No	0	6	6
131	R:R:S170	R:R:T253	4.8	No	No	0	9	5
132	R:R:I249	R:R:L171	4.28	No	No	0	6	6
133	R:R:L171	R:R:T253	2.95	No	No	0	6	5
134	R:R:L325	R:R:R173	6.07	No	No	0	8	9
135	R:R:Q178	R:R:Y174	3.38	No	Yes	0	6	8
136	R:R:L256	R:R:Y174	8.21	No	Yes	0	5	8
137	R:R:T257	R:R:Y174	3.75	No	Yes	0	9	8
138	R:R:A176	R:R:H183	7.32	No	Yes	0	8	7
139	R:R:I177	R:R:T257	4.56	No	No	0	9	9
140	R:R:I177	R:R:S260	3.1	No	No	0	9	6
141	R:R:I177	R:R:L261	4.28	No	Yes	0	9	8
142	R:R:Q178	R:R:S260	2.89	No	No	0	6	6
143	R:R:H182	R:R:N179	6.38	No	No	0	5	6
144	R:R:F186	R:R:H183	11.31	No	Yes	0	4	7
145	R:R:H183	R:R:N187	16.58	Yes	No	0	7	6
146	R:R:F193	R:R:R189	13.9	No	No	0	4	4
147	R:R:I206	R:R:S242	4.64	No	No	1	6	6
148	R:R:M208	R:R:P209	5.03	No	No	0	4	7
149	R:R:F234	R:R:P209	7.22	No	No	0	7	7
150	R:R:I210	R:R:P211	3.39	Yes	No	0	6	5
151	R:R:I210	R:R:L229	4.28	Yes	No	2	6	4
152	R:R:F213	R:R:K220	11.17	No	No	0	4	3
153	R:R:G214	R:R:V221	5.52	No	No	0	7	3
154	R:R:D217	R:R:Q216	11.75	No	No	0	4	6
155	R:R:D217	R:R:K220	16.59	No	No	0	4	3
156	R:R:F222	R:R:G225	3.01	Yes	No	0	2	3
157	R:R:E224	R:R:K223	20.25	No	No	0	2	3
158	R:R:A230	R:R:K223	3.21	No	No	0	3	3
159	R:R:L229	R:R:V235	4.47	No	No	0	4	6
160	R:R:D232	R:R:V347	5.84	No	No	0	4	5
161	R:R:F234	R:R:I237	3.77	No	No	0	7	4
162	R:R:N343	R:R:V235	4.43	No	No	0	7	6
163	R:R:I237	R:R:L236	2.85	No	No	0	4	6
164	R:R:F340	R:R:S239	3.96	Yes	No	0	7	6
165	R:R:I344	R:R:S239	4.64	No	No	0	5	6
166	R:R:F240	R:R:V241	5.24	No	No	1	4	4
167	R:R:F240	R:R:F244	6.43	No	No	1	4	5
168	R:R:F240	R:R:I245	7.54	No	No	1	4	5
169	R:R:I245	R:R:V241	3.07	No	No	1	5	4
170	R:R:F243	R:R:F244	7.5	Yes	No	1	8	5
171	R:R:F243	R:R:L247	12.18	Yes	No	0	8	6
172	R:R:F243	R:R:W336	7.02	Yes	Yes	1	8	8
173	R:R:C337	R:R:F243	4.19	No	Yes	0	6	8
174	R:R:F243	R:R:F340	23.58	Yes	Yes	1	8	7
175	R:R:F244	R:R:F340	4.29	No	Yes	1	5	7
176	R:R:I245	R:R:P246	3.39	No	Yes	0	5	9
177	R:R:M250	R:R:W336	3.49	No	Yes	0	8	8
178	R:R:F255	R:R:Y254	13.41	No	Yes	0	1	9
179	R:R:I258	R:R:Y254	7.25	No	Yes	0	5	9
180	R:R:L325	R:R:Y254	5.86	No	Yes	0	8	9
181	R:R:G326	R:R:Y254	4.35	No	Yes	0	6	9
182	R:R:F329	R:R:Y254	36.1	No	Yes	0	8	9
183	R:R:K259	R:R:L256	2.82	No	No	0	4	5
184	R:R:L325	R:R:T257	2.95	No	No	0	8	9
185	R:R:C322	R:R:I258	4.91	No	No	0	7	5
186	R:R:E318	R:R:L261	3.98	No	Yes	0	8	8
187	R:R:C322	R:R:L261	6.35	No	Yes	0	7	8
188	R:R:E318	R:R:N317	3.94	No	No	0	8	6
189	R:R:K320	R:R:K323	10.06	No	No	0	8	7
190	R:R:K320	R:R:V324	4.55	No	No	0	8	8
191	R:R:F383	R:R:V324	7.87	No	No	0	7	8
192	R:R:F329	R:R:V333	5.24	No	No	0	8	6
193	R:R:F330	R:R:V334	6.55	No	No	0	5	5
194	R:R:F332	R:R:W336	8.02	Yes	Yes	0	9	8
195	R:R:F332	R:R:V375	3.93	Yes	Yes	0	9	6
196	R:R:F332	R:R:N376	4.83	Yes	Yes	0	9	9
197	R:R:I368	R:R:M335	4.37	No	No	0	7	8
198	R:R:M335	R:R:S372	3.07	No	No	0	8	9
199	R:R:M335	R:R:V375	3.04	No	Yes	0	8	6
200	R:R:S372	R:R:W336	6.18	No	Yes	0	9	8
201	R:R:F365	R:R:P338	5.78	Yes	No	0	5	9
202	R:R:F339	R:R:F340	3.22	Yes	Yes	1	7	7
203	R:R:F339	R:R:V366	6.55	Yes	No	0	7	6
204	R:R:L362	R:R:T342	4.42	No	No	0	3	5
205	R:R:F365	R:R:T342	5.19	Yes	No	0	5	5
206	R:R:C349	R:R:M345	3.24	No	No	0	3	4
207	R:R:C349	R:R:I348	3.27	No	No	0	3	4
208	R:R:C349	R:R:C353	3.64	No	No	0	3	3
209	R:R:D356	R:R:N354	6.73	No	No	0	2	1
210	R:R:N354	R:R:V357	8.87	No	No	0	1	5
211	R:R:F365	R:R:L361	4.87	Yes	No	0	5	4
212	R:R:V366	R:R:Y370	7.57	No	Yes	0	6	7
213	R:R:G369	R:R:S372	3.71	No	No	0	7	9
214	R:R:N376	R:R:Y380	9.3	Yes	Yes	0	9	9
215	R:R:Y380	R:R:Y387	3.97	Yes	Yes	0	9	8
216	R:R:F391	R:R:T381	6.49	No	No	0	6	7
217	R:R:F383	R:R:L382	4.87	No	No	0	7	5
218	R:R:N384	R:R:T386	2.92	No	Yes	0	9	6
219	R:R:N384	R:R:Y387	4.65	No	Yes	0	9	8
220	R:R:K385	R:R:R388	6.19	No	No	0	5	9
221	R:R:A390	R:R:Y394	4	No	Yes	0	7	4
222	R:R:R393	R:R:Y394	12.35	No	Yes	0	4	4
223	R:R:F222	R:R:S145	2.64	Yes	No	0	2	3
224	R:R:F186	R:R:V175	2.62	No	No	0	4	5
225	R:R:F329	R:R:V251	2.62	No	No	0	8	5
226	R:R:F332	R:R:V328	2.62	Yes	No	0	9	8
227	R:R:F383	R:R:V379	2.62	No	No	0	7	8
228	R:R:A119	R:R:W200	2.59	No	No	0	8	9
229	R:R:R388	R:R:T381	2.59	No	No	0	9	7
230	R:R:D172	R:R:H183	2.52	No	Yes	0	9	7
231	R:R:V175	R:R:Y174	2.52	No	Yes	0	5	8
232	R:R:I169	R:R:R173	2.51	No	No	0	9	9
233	R:R:I181	R:R:R185	2.51	No	No	0	7	4
234	R:R:F112	R:R:K195	2.48	No	No	0	8	6
235	R:R:S131	R:R:W151	2.47	No	Yes	0	7	5
236	R:R:S131	R:R:W367	2.47	No	Yes	0	7	6
237	R:R:F330	R:R:L331	2.44	No	No	0	5	6
238	R:R:F339	R:R:L362	2.44	Yes	No	0	7	3
239	R:R:T134	R:R:W141	2.43	No	Yes	0	5	7
240	R:R:D231	R:R:F234	2.39	No	No	0	5	7
241	R:R:A90	R:R:G91	1.95	No	No	0	4	8
242	R:R:A149	R:R:G214	1.95	No	No	0	6	7
243	R:R:G225	R:R:S226	1.86	No	No	0	3	4
244	R:R:G205	R:R:V204	1.84	No	No	0	4	4
245	R:R:G238	R:R:V241	1.84	No	No	0	6	4
246	R:R:A390	R:R:A98	1.79	No	No	0	7	7
247	R:R:A108	R:R:A192	1.79	No	No	0	5	7
248	R:R:G238	R:R:I237	1.76	No	No	0	6	4
249	R:R:A168	R:R:V199	1.7	No	No	0	7	6
250	R:R:M128	R:R:P129	1.68	Yes	No	0	8	8
251	R:R:L133	R:R:P142	1.64	No	No	0	4	3
252	R:R:L147	R:R:P144	1.64	No	No	0	5	7
253	R:R:L215	R:R:P211	1.64	Yes	No	0	5	5
254	R:R:C337	R:R:I341	1.64	No	No	0	6	6
255	R:R:N179	R:R:P180	1.63	No	No	0	6	8
256	R:R:S389	R:R:S392	1.63	No	No	0	4	3
257	R:R:A346	R:R:I358	1.62	No	No	0	4	4
258	R:R:S188	R:R:T190	1.6	No	No	0	7	5
259	R:R:V328	R:R:V379	1.6	No	No	0	8	8
260	R:R:V375	R:R:V379	1.6	Yes	No	0	6	8
261	R:R:A374	R:R:L87	1.58	No	No	0	6	4
262	R:R:A321	R:R:L261	1.58	No	Yes	0	8	8
263	R:R:I315	R:R:S316	1.55	No	No	0	5	6
264	R:R:I327	R:R:V328	1.54	No	No	0	6	8
265	R:R:C322	R:R:Q262	1.53	No	No	0	7	6
266	R:R:K385	R:R:S389	1.53	No	No	0	5	4
267	R:R:I197	R:R:T201	1.52	No	No	0	2	4
268	R:R:K220	R:R:V221	1.52	No	No	0	3	3
269	R:R:I252	R:R:T248	1.52	No	No	0	5	3
270	R:R:I358	R:R:T342	1.52	No	No	0	4	5
271	R:R:L331	R:R:V375	1.49	No	Yes	0	6	6
272	R:R:L361	R:R:V357	1.49	No	No	0	4	5
273	R:R:N343	R:R:V347	1.48	No	No	0	7	5
274	R:R:I85	R:R:I86	1.47	No	No	0	6	4
275	R:R:I344	R:R:I348	1.47	No	No	0	5	4
276	R:R:G138	R:R:Y139	1.45	No	No	0	5	3
277	R:R:E351	R:R:S352	1.44	No	No	0	5	2
278	R:R:H183	R:R:S184	1.39	Yes	No	0	7	6
279	R:R:I315	R:R:Q319	1.37	No	No	0	5	5
280	R:R:P142	R:R:W141	1.35	No	Yes	0	3	7
281	R:R:E351	R:R:K350	1.35	No	No	0	5	1
282	R:R:N179	R:R:Q178	1.32	No	No	0	6	6
283	R:R:F365	R:R:V364	1.31	Yes	No	0	5	4
284	R:R:F186	R:R:K191	1.24	No	No	0	4	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.27556	9	1	0
2	R:R:N92	7.12	4	1	9
3	R:R:V95	3.9875	4	0	9
4	R:R:L105	8.12	4	3	8
5	R:R:N110	9.1675	4	3	9
6	R:R:L116	5.72	4	1	9
7	R:R:L123	3.78167	6	1	7
8	R:R:L126	3.21	4	1	5
9	R:R:M128	6.69667	6	1	8
10	R:R:W141	7.89625	8	2	7
11	R:R:W151	9.2675	4	2	5
12	R:R:D155	7.002	5	1	8
13	R:R:L157	5.146	5	1	6
14	R:R:F158	6.0875	4	1	7
15	R:R:M164	3.8075	4	0	6
16	R:R:H165	6.2325	4	0	8
17	R:R:Y174	4.465	4	0	8
18	R:R:H183	7.824	5	0	7
19	R:R:I210	3.805	4	2	6
20	R:R:L215	4.1	4	0	5
21	R:R:F222	4.76	4	2	2
22	R:R:F243	9.915	6	1	8
23	R:R:P246	3.475	4	0	9
24	R:R:Y254	13.394	5	0	9
25	R:R:L261	4.0475	4	0	8
26	R:R:F332	4.85	4	0	9
27	R:R:W336	6.40286	7	1	8
28	R:R:F339	5.5475	4	1	7
29	R:R:F340	9.006	5	1	7
30	R:R:F365	4.2875	4	0	5
31	R:R:W367	4.18	4	0	6
32	R:R:Y370	10.6125	4	1	7
33	R:R:V375	2.515	4	0	6
34	R:R:N376	5.9375	4	1	9
35	R:R:Y380	7.7825	4	0	9
36	R:R:T386	5.1525	4	3	6
37	R:R:Y387	5.235	6	3	8
38	R:R:Y394	8.5075	4	0	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D155	31.6187	8.9	Yes	Yes	1	0	8
2	R:R:D155	R:R:V127	33.7365	8.76	Yes	No	0	8	8
3	R:R:V127	R:R:W151	32.5182	6.13	No	Yes	0	8	5
4	R:R:S131	R:R:W151	13.3182	2.47	No	Yes	0	7	5
5	R:R:S131	R:R:W367	12.0344	2.47	No	Yes	0	7	6
6	R:R:D155	R:R:L123	10.8249	4.07	Yes	Yes	1	8	7
7	R:R:F158	R:R:L123	13.8073	4.87	Yes	Yes	1	7	7
8	R:R:F158	R:R:L122	11.768	10.96	Yes	No	1	7	7
9	R:R:L122	R:R:M121	12.3663	4.24	No	No	1	7	7
10	L:L:?1	R:R:W336	71.1847	4.98	Yes	Yes	1	0	8
11	R:R:L166	R:R:W336	44.8889	4.56	No	Yes	1	8	8
12	R:R:L166	R:R:N376	40.8803	2.75	No	Yes	1	8	9
13	R:R:N376	R:R:Y380	100	9.3	Yes	Yes	0	9	9
14	R:R:V95	R:R:Y380	23.3265	3.79	Yes	Yes	0	9	9
15	R:R:F332	R:R:W336	52.6047	8.02	Yes	Yes	0	9	8
16	R:R:F332	R:R:N376	49.8494	4.83	Yes	Yes	0	9	9
17	R:R:M121	R:R:N92	10.1175	14.02	No	Yes	1	7	9
18	R:R:F391	R:R:V95	12.4405	5.24	No	Yes	0	6	9
19	R:R:Y380	R:R:Y387	37.7014	3.97	Yes	Yes	0	9	8
20	R:R:V99	R:R:Y387	12.2833	3.79	No	Yes	3	7	8
21	R:R:M114	R:R:V99	11.7942	6.09	No	No	0	5	7
22	R:R:A98	R:R:Y387	10.6065	2.67	No	Yes	0	7	8
23	R:R:M114	R:R:Y111	11.2571	5.99	No	No	0	5	4
24	R:R:L113	R:R:Y380	58.3337	14.07	No	Yes	0	8	9
25	R:R:H165	R:R:L116	11.196	6.43	Yes	Yes	0	8	9
26	R:R:I169	R:R:L113	54.5522	2.85	No	No	0	9	8
27	R:R:W141	R:R:W151	18.2612	14.99	Yes	Yes	2	7	5
28	L:L:?1	R:R:V156	27.4966	4.88	Yes	No	0	0	6
29	R:R:I210	R:R:V156	23.0427	4.61	Yes	No	0	6	6
30	R:R:I210	R:R:P211	15.3967	3.39	Yes	No	0	6	5
31	R:R:L215	R:R:P211	15.8989	1.64	Yes	No	0	5	5
32	R:R:A149	R:R:L215	11.2746	4.73	No	Yes	0	6	5
33	R:R:F243	R:R:W336	19.2481	7.02	Yes	Yes	1	8	8
34	L:L:?1	R:R:F340	15.3443	9.98	Yes	Yes	1	0	7
35	R:R:I163	R:R:W336	17.3006	10.57	No	Yes	1	8	8
36	R:R:I163	R:R:P246	16.9687	3.39	No	Yes	0	8	9
37	R:R:I169	R:R:R173	53.1505	2.51	No	No	0	9	9
38	R:R:L325	R:R:R173	51.6397	6.07	No	No	0	8	9
39	R:R:L325	R:R:T257	36.2735	2.95	No	No	0	8	9
40	R:R:T257	R:R:Y174	25.2391	3.75	No	Yes	0	9	8
41	R:R:V175	R:R:Y174	13.6282	2.52	No	Yes	0	5	8
42	R:R:F186	R:R:V175	11.9034	2.62	No	No	0	4	5
43	R:R:I177	R:R:T257	10.3009	4.56	No	No	0	9	9
44	R:R:F240	R:R:F244	12.685	6.43	No	No	1	4	5
45	R:R:F240	R:R:V241	10.7987	5.24	No	No	1	4	4
46	R:R:G238	R:R:V241	15.9818	1.84	No	No	0	6	4
47	R:R:G238	R:R:I237	13.6719	1.76	No	No	0	6	4
48	R:R:F340	R:R:S239	13.8553	3.96	Yes	No	0	7	6
49	R:R:I344	R:R:S239	11.5672	4.64	No	No	0	5	6
50	R:R:L325	R:R:Y254	15.0605	5.86	No	Yes	0	8	9
51	R:R:F332	R:R:V375	11.7942	3.93	Yes	Yes	0	9	6
52	R:R:F383	R:R:V379	11.1	2.62	No	No	0	7	8
53	L:L:?1	R:R:F339	16.8202	9.98	Yes	Yes	1	0	7
54	R:R:F339	R:R:L362	16.4185	2.44	Yes	No	0	7	3
55	R:R:L362	R:R:T342	15.1784	4.42	No	No	0	3	5
56	R:R:F365	R:R:T342	10.7157	5.19	Yes	No	0	5	5
57	R:R:L116	R:R:N376	13.5933	6.87	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D155	8.9	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:V156	4.88	1	Yes	No	0	6	0	1
L:L:?1	R:R:S159	9.84	1	Yes	No	0	7	0	1
L:L:?1	R:R:S242	3.28	1	Yes	No	0	6	0	1
L:L:?1	R:R:W336	4.98	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F339	9.98	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F340	9.98	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:G369	4.67	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y370	8.97	1	Yes	Yes	0	7	0	1
R:R:L123	R:R:M128	2.83	1	Yes	Yes	7	8	2	2
R:R:D155	R:R:L123	4.07	1	Yes	Yes	8	7	1	2
R:R:L123	R:R:S159	4.5	1	Yes	No	7	7	2	1
R:R:D155	R:R:V127	8.76	1	Yes	No	8	8	1	2
R:R:M128	R:R:Y370	15.57	1	Yes	Yes	8	7	2	1
R:R:D155	R:R:S159	2.94	1	Yes	No	8	7	1	1
R:R:D155	R:R:Y370	10.34	1	Yes	Yes	8	7	1	1
R:R:S207	R:R:V156	3.23	1	No	No	7	6	2	1
R:R:I210	R:R:V156	4.61	2	Yes	No	6	6	2	1
R:R:I206	R:R:T160	3.04	1	No	No	6	7	2	2
R:R:S242	R:R:T160	7.99	1	No	No	6	7	1	2
R:R:F243	R:R:I163	5.02	1	Yes	No	8	8	2	2
R:R:I163	R:R:W336	10.57	1	No	Yes	8	8	2	1
R:R:L166	R:R:W336	4.56	1	No	Yes	8	8	2	1
R:R:I206	R:R:S242	4.64	1	No	No	6	6	2	1
R:R:F340	R:R:S239	3.96	1	Yes	No	7	6	1	2
R:R:F243	R:R:F244	7.5	1	Yes	No	8	5	2	2
R:R:F243	R:R:W336	7.02	1	Yes	Yes	8	8	2	1
R:R:F243	R:R:F340	23.58	1	Yes	Yes	8	7	2	1
R:R:F244	R:R:F340	4.29	1	No	Yes	5	7	2	1
R:R:M250	R:R:W336	3.49	0	No	Yes	8	8	2	1
R:R:F332	R:R:W336	8.02	0	Yes	Yes	9	8	2	1
R:R:S372	R:R:W336	6.18	0	No	Yes	9	8	2	1
R:R:F339	R:R:F340	3.22	1	Yes	Yes	7	7	1	1
R:R:F339	R:R:V366	6.55	1	Yes	No	7	6	1	2
R:R:V366	R:R:Y370	7.57	0	No	Yes	6	7	2	1
R:R:G369	R:R:S372	3.71	0	No	No	7	9	1	2
R:R:F339	R:R:L362	2.44	1	Yes	No	7	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9ASA_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.67
Number of Linked Nodes	247
Number of Links	284
Number of Hubs	38
Number of Links mediated by Hubs	147
Number of Communities	3
Number of Nodes involved in Communities	48
Number of Links involved in Communities	69

Path Summary
Number Of Nodes in MetaPath	58
Number Of Links MetaPath	57
Number of Shortest Paths	45879
Length Of Smallest Path	3
Average Path Length	11.6252
Length of Longest Path	25
Minimum Path Strength	1.395
Average Path Strength	5.75264
Maximum Path Strength	24.755
Minimum Path Correlation	0.7
Average Path Correlation	0.919563
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	47.409
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.26
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1A
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1A
Name	6-AMINO HEXANOIC ACID
Synonyms
Identifier
Formula	C33 H40 N4 O6
Molecular Weight	588.694
SMILES
PubChem	5327090
Formal Charge	0
Total Atoms	83
Total Chiral Atoms	4
Total Bonds	86
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P28223
Sequence	>9ASA_nogp_Chain_R V V I I L T I A G N I L V I M A V S L E K K L Q N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G Y R W P L P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N P I H H S R F N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D S K V F K E G S C L L A D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C K E S C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T Y R S A F S R Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6WGT	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WH4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WHA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.36	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WHA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-		3.36	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	8ZMG	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Pimavanserin	-	-	3.4	2024-08-28	doi.org/10.1021/acs.jmedchem.4c01244
	7RAN	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.45	2022-07-06	doi.org/10.1038/s41586-022-05258-z
	7RAN (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-		3.45	2022-07-06	doi.org/10.1038/s41586-022-05258-z
	7VOD	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Cariprazine	-	-	3.3	2021-12-22	doi.org/10.1038/s41593-021-00971-w
	7VOE	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Aripiprazole	-	-	2.9	2021-12-22	doi.org/10.1038/s41593-021-00971-w
	6A93	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Risperidone	-	-	3	2019-02-13	doi.org/10.1038/s41594-018-0180-z
	6A94	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Zotepine	-	-	2.9	2019-02-13	doi.org/10.1038/s41594-018-0180-z
	7WC4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	-	3.2	2022-01-26	doi.org/10.1126/science.abl8615
	7WC5	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	-	3.2	2022-01-26	doi.org/10.1126/science.abl8615
	7WC6	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	2.6	2022-01-26	doi.org/10.1126/science.abl8615
	7WC7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	-	2.6	2022-01-26	doi.org/10.1126/science.abl8615
	7WC8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lumateperone	-	-	2.45	2022-01-26	doi.org/10.1126/science.abl8615
	7WC9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 162421364	-	-	2.5	2022-01-26	doi.org/10.1126/science.abl8615
	8UWL	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.8	2024-05-29	doi.org/10.1126/science.adn6354
	8UWL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-		2.8	2024-05-29	doi.org/10.1126/science.adn6354
	8V6U	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 171392456	-	chim(NtGi2-Gs-CtGq)/β1/γ2	3	2024-05-29	doi.org/10.1126/science.adn6354
	8V6U (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 171392456	-		3	2024-05-29	doi.org/10.1126/science.adn6354
	8JT8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	(R)-IHCH-7179	-	-	2.7	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	9ARX	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	-	3.24	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARY	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.27	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARY (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-		3.27	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARZ	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-	-	3.37	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS0	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS0 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-		3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS1	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-	-	3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS2	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.21	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-		3.21	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS3	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.18	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.06	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS4 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-		3.06	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS5	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-	-	3.34	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS6	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-		3.07	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	-	2.72	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-	-	3.47	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ASA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.12	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ASA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-		3.12	2025-04-02	doi.org/10.1038/s41467-025-57956-7

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