psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L79	R:R:T81	10.32	No	No	3	4	6
2	R:R:L79	R:R:M132	7.07	No	No	3	4	6
3	R:R:M132	R:R:T81	6.02	No	No	3	6	6
4	R:R:T81	R:R:W367	12.13	No	Yes	0	6	6
5	R:R:L371	R:R:V84	2.98	No	No	0	4	7
6	R:R:I85	R:R:M128	7.29	No	Yes	0	6	8
7	R:R:D120	R:R:T88	4.34	Yes	Yes	1	9	7
8	R:R:G124	R:R:T88	3.64	No	Yes	1	6	7
9	R:R:M128	R:R:T88	3.01	Yes	Yes	1	8	7
10	R:R:A374	R:R:T88	5.03	No	Yes	0	6	7
11	R:R:I89	R:R:I93	2.94	No	No	0	5	3
12	R:R:F125	R:R:I89	7.54	No	No	0	4	5
13	R:R:D120	R:R:N92	13.46	Yes	Yes	1	9	9
14	R:R:M121	R:R:N92	7.01	No	Yes	0	7	9
15	R:R:N92	R:R:P377	4.89	Yes	No	1	9	9
16	R:R:F391	R:R:L94	3.65	No	No	0	6	6
17	R:R:T381	R:R:V95	3.17	Yes	No	0	7	9
18	R:R:I118	R:R:I96	4.42	No	No	0	6	6
19	R:R:I96	R:R:M121	2.92	No	No	0	6	7
20	R:R:M97	R:R:Y394	10.78	No	No	0	4	4
21	R:R:A98	R:R:Y387	2.67	No	Yes	0	7	8
22	R:R:V99	R:R:Y111	2.52	No	No	0	7	4
23	R:R:M114	R:R:V99	3.04	No	No	0	5	7
24	R:R:L101	R:R:S100	4.5	No	No	0	5	1
25	R:R:L101	R:R:Y394	3.52	No	No	0	5	4
26	R:R:E102	R:R:K104	6.75	No	No	0	6	6
27	R:R:E102	R:R:L105	6.63	No	No	0	6	8
28	R:R:L105	R:R:Y387	8.21	No	Yes	0	8	8
29	R:R:Q106	R:R:Y111	13.53	No	No	0	7	4
30	R:R:N110	R:R:Y387	10.47	No	Yes	0	9	8
31	R:R:F112	R:R:H165	10.18	Yes	Yes	0	8	8
32	R:R:F112	R:R:I169	5.02	Yes	No	0	8	9
33	R:R:F112	R:R:K195	6.2	Yes	No	0	8	6
34	R:R:F112	R:R:I196	2.51	Yes	No	0	8	8
35	R:R:L113	R:R:T381	4.42	No	Yes	0	8	7
36	R:R:H165	R:R:S115	5.58	Yes	No	0	8	9
37	R:R:I196	R:R:S115	7.74	No	No	0	8	9
38	R:R:H165	R:R:L116	11.57	Yes	No	0	8	9
39	R:R:A119	R:R:W200	2.59	No	No	0	8	9
40	R:R:D120	R:R:S373	5.89	Yes	No	0	9	9
41	R:R:D120	R:R:P377	3.22	Yes	No	1	9	9
42	R:R:F158	R:R:L122	2.44	Yes	No	0	7	7
43	R:R:G124	R:R:L123	3.42	No	Yes	0	6	7
44	R:R:L123	R:R:V127	4.47	Yes	No	0	7	8
45	R:R:F158	R:R:L123	10.96	Yes	Yes	0	7	7
46	R:R:L123	R:R:S373	3	Yes	No	0	7	9
47	R:R:G124	R:R:M128	5.24	No	Yes	1	6	8
48	R:R:L126	R:R:L154	4.15	No	No	0	5	5
49	R:R:V127	R:R:W151	6.13	No	Yes	0	8	5
50	R:R:D155	R:R:V127	5.84	No	No	0	8	8
51	R:R:V130	R:R:W151	11.03	No	Yes	0	4	5
52	R:R:S131	R:R:W151	2.47	No	Yes	0	7	5
53	R:R:S131	R:R:W367	4.94	No	Yes	0	7	6
54	R:R:L136	R:R:M132	9.9	No	No	0	5	6
55	R:R:I135	R:R:N363	4.25	No	No	0	5	4
56	R:R:P142	R:R:Y137	8.34	No	No	0	3	4
57	R:R:G138	R:R:Y139	2.9	No	No	0	5	3
58	R:R:L143	R:R:W141	6.83	No	Yes	0	5	7
59	R:R:W141	R:R:W151	2.81	Yes	Yes	0	7	5
60	R:R:G225	R:R:W141	2.81	No	Yes	0	3	7
61	R:R:C227	R:R:W141	5.22	No	Yes	0	9	7
62	R:R:L143	R:R:P144	4.93	No	No	4	5	7
63	R:R:L143	R:R:L147	9.69	No	No	4	5	5
64	R:R:L147	R:R:P144	6.57	No	No	4	5	7
65	R:R:D218	R:R:K146	2.77	No	No	0	3	1
66	R:R:L147	R:R:V150	2.98	No	No	0	5	4
67	R:R:C148	R:R:C227	5.46	No	No	0	9	9
68	R:R:A149	R:R:L215	3.15	No	No	0	6	5
69	R:R:I152	R:R:W151	3.52	No	Yes	0	5	5
70	R:R:C227	R:R:I152	3.27	No	No	0	9	5
71	R:R:S207	R:R:Y153	5.09	No	No	0	7	6
72	R:R:M208	R:R:Y153	3.59	No	No	0	4	6
73	R:R:P211	R:R:Y153	12.52	No	No	0	5	6
74	R:R:F158	R:R:L154	3.65	Yes	No	0	7	5
75	R:R:D155	R:R:Y370	10.34	No	Yes	2	8	7
76	L:L:?1	R:R:D155	16.79	Yes	No	2	0	8
77	L:L:?1	R:R:V156	10.75	Yes	No	0	0	6
78	R:R:F158	R:R:L157	3.65	Yes	No	0	7	6
79	R:R:L157	R:R:S207	7.51	No	No	0	6	7
80	L:L:?1	R:R:S159	7.74	Yes	No	0	0	7
81	R:R:M164	R:R:T160	3.01	No	No	0	6	7
82	R:R:S203	R:R:T160	4.8	No	No	0	8	7
83	R:R:S242	R:R:T160	3.2	No	No	0	6	7
84	R:R:A161	R:R:W200	3.89	No	No	0	8	9
85	R:R:A161	R:R:S203	3.42	No	No	0	8	8
86	R:R:M164	R:R:V199	3.04	No	No	0	6	6
87	R:R:I202	R:R:M164	2.92	No	No	0	5	6
88	R:R:H165	R:R:V199	6.92	Yes	No	0	8	6
89	R:R:F332	R:R:L166	2.44	No	No	0	9	8
90	R:R:L166	R:R:N376	8.24	No	Yes	1	8	9
91	R:R:L166	R:R:Y380	3.52	No	Yes	1	8	9
92	R:R:C167	R:R:M250	3.24	No	Yes	0	6	8
93	R:R:M250	R:R:S170	3.07	Yes	No	0	8	9
94	R:R:S170	R:R:T253	6.4	No	No	0	9	5
95	R:R:I249	R:R:L171	4.28	No	No	0	6	6
96	R:R:L171	R:R:T253	2.95	No	No	0	6	5
97	R:R:D172	R:R:K195	6.91	No	No	0	9	6
98	R:R:R173	R:R:Y380	4.12	No	Yes	0	9	9
99	R:R:Q178	R:R:Y174	6.76	No	Yes	0	6	8
100	R:R:T253	R:R:Y174	4.99	No	Yes	0	5	8
101	R:R:L256	R:R:Y174	7.03	No	Yes	0	5	8
102	R:R:T257	R:R:Y174	4.99	No	Yes	0	9	8
103	R:R:A176	R:R:H183	5.85	No	No	0	8	7
104	R:R:I177	R:R:L261	4.28	No	Yes	0	9	8
105	R:R:Q178	R:R:S260	7.22	No	No	0	6	6
106	R:R:H182	R:R:N179	3.83	No	No	0	5	6
107	R:R:I181	R:R:R185	6.26	No	No	0	7	4
108	R:R:R185	R:R:S184	2.64	No	No	0	4	6
109	R:R:N187	R:R:R189	20.49	No	No	0	6	4
110	R:R:S188	R:R:T190	6.4	No	No	0	7	5
111	R:R:K191	R:R:L194	4.23	No	No	0	6	3
112	R:R:M208	R:R:P209	3.35	No	No	0	4	7
113	R:R:I210	R:R:P211	8.47	No	No	0	6	5
114	R:R:I210	R:R:L229	4.28	No	No	6	6	4
115	R:R:F234	R:R:I210	10.05	No	No	6	7	6
116	R:R:D218	R:R:L215	4.07	No	No	0	3	5
117	R:R:D217	R:R:K220	15.21	No	No	0	4	3
118	R:R:F222	R:R:G225	4.52	No	No	0	2	3
119	R:R:K223	R:R:L228	2.82	No	No	0	3	4
120	R:R:F234	R:R:L229	2.44	No	No	6	7	4
121	R:R:L229	R:R:V235	2.98	No	No	0	4	6
122	R:R:D231	R:R:N233	4.04	No	No	0	5	3
123	R:R:D232	R:R:V347	8.76	No	No	0	4	5
124	R:R:I237	R:R:N233	5.66	No	No	0	4	3
125	R:R:N343	R:R:V235	4.43	No	No	0	7	6
126	R:R:V235	R:R:V347	3.21	No	No	0	6	5
127	R:R:L236	R:R:V347	4.47	No	No	0	6	5
128	R:R:F340	R:R:S239	6.61	Yes	No	0	7	6
129	R:R:I344	R:R:S239	6.19	No	No	0	5	6
130	R:R:F240	R:R:F244	3.22	No	No	0	4	5
131	R:R:F240	R:R:I245	2.51	No	No	0	4	5
132	L:L:?1	R:R:S242	4.64	Yes	No	0	0	6
133	R:R:F243	R:R:F244	6.43	Yes	No	0	8	5
134	R:R:F243	R:R:L247	4.87	Yes	No	0	8	6
135	R:R:F243	R:R:W336	3.01	Yes	Yes	2	8	8
136	R:R:F243	R:R:F340	21.43	Yes	Yes	2	8	7
137	R:R:I245	R:R:P246	3.39	No	No	0	5	9
138	R:R:I252	R:R:T248	3.04	No	No	0	5	3
139	R:R:F329	R:R:M250	3.73	No	Yes	0	8	8
140	R:R:F332	R:R:M250	7.46	No	Yes	0	9	8
141	R:R:F329	R:R:V251	5.24	No	No	0	8	5
142	R:R:I258	R:R:Y254	12.09	Yes	No	0	5	9
143	R:R:G326	R:R:Y254	4.35	No	No	0	6	9
144	R:R:F329	R:R:Y254	15.47	No	No	0	8	9
145	R:R:I258	R:R:T257	3.04	Yes	No	5	5	9
146	R:R:L325	R:R:T257	2.95	No	No	5	8	9
147	R:R:C322	R:R:I258	3.27	No	Yes	0	7	5
148	R:R:I258	R:R:L325	2.85	Yes	No	5	5	8
149	R:R:E264	R:R:S260	2.87	No	No	0	7	6
150	R:R:E318	R:R:L261	2.65	Yes	Yes	0	8	8
151	R:R:C322	R:R:L261	3.17	No	Yes	0	7	8
152	R:R:A265	R:R:E318	3.02	No	Yes	0	5	8
153	R:R:I315	R:R:S314	3.1	No	No	7	5	5
154	R:R:E318	R:R:S314	2.87	Yes	No	7	8	5
155	R:R:E318	R:R:I315	4.1	Yes	No	7	8	5
156	R:R:K320	R:R:K323	7.18	No	No	0	8	7
157	R:R:F383	R:R:K320	4.96	No	No	0	7	8
158	R:R:I327	R:R:K323	2.91	No	No	0	6	7
159	R:R:F383	R:R:V324	3.93	No	No	0	7	8
160	R:R:V328	R:R:Y380	3.79	No	Yes	0	8	9
161	R:R:L331	R:R:M335	8.48	No	No	0	6	8
162	R:R:M335	R:R:S372	10.73	No	No	0	8	9
163	R:R:F339	R:R:W336	3.01	Yes	Yes	2	7	8
164	R:R:F340	R:R:W336	3.01	Yes	Yes	2	7	8
165	R:R:G369	R:R:W336	5.63	No	Yes	0	7	8
166	R:R:S372	R:R:W336	2.47	No	Yes	0	9	8
167	R:R:F365	R:R:P338	4.33	No	No	0	5	9
168	R:R:F339	R:R:F340	9.65	Yes	Yes	2	7	7
169	R:R:F339	R:R:L362	2.44	Yes	No	0	7	3
170	L:L:?1	R:R:F339	15.06	Yes	Yes	2	0	7
171	L:L:?1	R:R:F340	15.06	Yes	Yes	2	0	7
172	R:R:L362	R:R:T342	4.42	No	No	0	3	5
173	R:R:F365	R:R:T342	9.08	No	No	0	5	5
174	L:L:?1	R:R:N343	2.83	Yes	No	0	0	7
175	R:R:I358	R:R:M345	2.92	Yes	No	0	4	4
176	R:R:D356	R:R:V357	2.92	No	No	0	2	5
177	R:R:L361	R:R:V357	2.98	No	No	0	4	5
178	R:R:F365	R:R:L361	7.31	No	No	0	5	4
179	R:R:V366	R:R:Y370	6.31	No	Yes	2	6	7
180	L:L:?1	R:R:V366	3.07	Yes	No	2	0	6
181	R:R:W367	R:R:Y370	7.72	Yes	Yes	0	6	7
182	L:L:?1	R:R:Y370	3.63	Yes	Yes	2	0	7
183	R:R:L371	R:R:V375	2.98	No	No	0	4	6
184	R:R:N376	R:R:P377	4.89	Yes	No	1	9	9
185	R:R:N376	R:R:Y380	5.81	Yes	Yes	1	9	9
186	R:R:L378	R:R:L382	4.15	No	No	0	6	5
187	R:R:T381	R:R:Y387	4.99	Yes	Yes	0	7	8
188	R:R:F391	R:R:T381	2.59	No	Yes	0	6	7
189	R:R:N384	R:R:T386	4.39	No	No	0	9	6
190	R:R:N384	R:R:Y387	6.98	No	Yes	0	9	8
191	R:R:K385	R:R:R388	14.85	No	No	0	5	9
192	R:R:K385	R:R:S389	4.59	No	No	0	5	4
193	R:R:D231	R:R:F234	2.39	No	No	0	5	7
194	R:R:F213	R:R:Q216	2.34	No	No	0	4	6
195	R:R:N363	R:R:W367	2.26	No	Yes	0	4	6
196	R:R:F186	R:R:R185	2.14	No	No	0	4	4
197	R:R:A90	R:R:G91	1.95	No	No	0	4	8
198	R:R:C337	R:R:P338	1.88	No	No	0	6	9
199	R:R:A149	R:R:P211	1.87	No	No	0	6	5
200	R:R:G214	R:R:V221	1.84	No	No	0	7	3
201	R:R:A108	R:R:A192	1.79	No	No	0	5	7
202	R:R:G238	R:R:I237	1.76	No	No	0	6	4
203	L:L:?1	R:R:G238	1.76	Yes	No	0	0	6
204	R:R:A117	R:R:V95	1.7	No	No	0	9	9
205	R:R:A168	R:R:V199	1.7	No	No	0	7	6
206	R:R:I163	R:R:P246	1.69	No	No	0	8	9
207	R:R:M128	R:R:P129	1.68	Yes	No	0	8	8
208	R:R:D218	R:R:G214	1.68	No	No	0	3	7
209	R:R:A265	R:R:T266	1.68	No	No	0	5	4
210	R:R:N179	R:R:P180	1.63	No	No	0	6	8
211	R:R:A346	R:R:I358	1.62	No	Yes	0	4	4
212	R:R:V95	R:R:V99	1.6	No	No	0	9	7
213	R:R:V324	R:R:V328	1.6	No	No	0	8	8
214	R:R:V328	R:R:V379	1.6	No	No	0	8	8
215	R:R:V375	R:R:V379	1.6	No	No	0	6	8
216	R:R:A82	R:R:L79	1.58	No	No	0	3	4
217	R:R:A321	R:R:L261	1.58	No	Yes	0	8	8
218	R:R:A117	R:R:N92	1.56	No	Yes	0	9	9
219	R:R:A108	R:R:N107	1.56	No	No	0	5	7
220	R:R:I206	R:R:V241	1.54	No	No	0	6	4
221	R:R:I252	R:R:V251	1.54	No	No	0	5	5
222	R:R:I368	R:R:V364	1.54	No	No	0	7	4
223	R:R:K220	R:R:S219	1.53	No	No	0	3	3
224	R:R:I197	R:R:T201	1.52	No	No	0	2	4
225	R:R:M208	R:R:V212	1.52	No	No	0	4	5
226	R:R:A265	R:R:Q262	1.52	No	No	0	5	6
227	R:R:M335	R:R:V334	1.52	No	No	0	8	5
228	R:R:I358	R:R:T342	1.52	Yes	No	0	4	5
229	R:R:G225	R:R:R140	1.5	No	No	0	3	4
230	R:R:L228	R:R:S226	1.5	No	No	0	4	4
231	R:R:L157	R:R:V204	1.49	No	No	0	6	4
232	R:R:N376	R:R:S162	1.49	Yes	No	0	9	9
233	R:R:L247	R:R:V333	1.49	No	No	0	6	6
234	R:R:I85	R:R:I86	1.47	No	No	0	6	4
235	R:R:I196	R:R:I197	1.47	No	No	0	8	2
236	R:R:I93	R:R:M97	1.46	No	No	0	3	4
237	R:R:I93	R:R:M121	1.46	No	No	0	3	7
238	R:R:G138	R:R:Y137	1.45	No	No	0	5	4
239	R:R:I395	R:R:L94	1.43	No	No	0	6	6
240	R:R:Q216	R:R:V212	1.43	No	No	0	6	5
241	R:R:H183	R:R:V175	1.38	No	No	0	7	5
242	R:R:I315	R:R:Q319	1.37	No	No	0	5	5
243	R:R:E355	R:R:I358	1.37	No	Yes	0	3	4
244	R:R:K103	R:R:Q106	1.36	No	No	0	6	7
245	R:R:N107	R:R:N110	1.36	No	No	0	7	9
246	R:R:P142	R:R:W141	1.35	No	Yes	0	3	7
247	R:R:E224	R:R:K223	1.35	No	No	0	2	3
248	R:R:H182	R:R:I181	1.33	No	No	0	5	7
249	R:R:N179	R:R:Q178	1.32	No	No	0	6	6
250	R:R:F240	R:R:V241	1.31	No	No	0	4	4
251	R:R:F330	R:R:V333	1.31	No	No	0	5	6
252	R:R:F193	R:R:T190	1.3	No	No	0	4	5
253	R:R:S226	R:R:Y139	1.27	No	No	0	4	3
254	R:R:D172	R:R:H183	1.26	No	No	0	9	7
255	R:R:V175	R:R:Y174	1.26	No	Yes	0	5	8
256	R:R:F383	R:R:L382	1.22	No	No	0	7	5
257	R:R:L382	R:R:R388	1.21	No	No	0	5	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:T88	4.005	4	1	7
2	R:R:N92	6.73	4	1	9
3	R:R:F112	5.9775	4	0	8
4	R:R:D120	6.7275	4	1	9
5	R:R:L123	5.4625	4	0	7
6	R:R:M128	4.305	4	1	8
7	R:R:W141	3.804	5	0	7
8	R:R:W151	5.192	5	0	5
9	R:R:F158	5.175	4	0	7
10	R:R:H165	8.5625	4	0	8
11	R:R:Y174	5.006	5	0	8
12	R:R:F243	8.935	4	2	8
13	R:R:M250	4.375	4	0	8
14	R:R:I258	5.3125	4	5	5
15	R:R:L261	2.92	4	0	8
16	R:R:E318	3.16	4	7	8
17	R:R:W336	3.426	5	2	8
18	R:R:F339	7.54	4	2	7
19	R:R:F340	11.152	5	2	7
20	R:R:I358	1.8575	4	0	4
21	R:R:W367	6.7625	4	0	6
22	R:R:Y370	7	4	2	7
23	R:R:N376	5.1075	4	1	9
24	R:R:Y380	4.31	4	1	9
25	R:R:T381	3.7925	4	0	7
26	R:R:Y387	6.664	5	0	8
27	L:L:?1	8.133	10	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T81	R:R:W367	14.92	12.13	No	Yes	0	6	6
2	R:R:V328	R:R:Y380	30.012	3.79	No	Yes	0	8	9
3	R:R:N376	R:R:Y380	25.5894	5.81	Yes	Yes	1	9	9
4	R:R:N376	R:R:P377	79.6765	4.89	Yes	No	1	9	9
5	R:R:D120	R:R:P377	61.5987	3.22	Yes	No	1	9	9
6	R:R:D120	R:R:S373	99.63	5.89	Yes	No	0	9	9
7	R:R:L123	R:R:S373	100	3	Yes	No	0	7	9
8	R:R:L123	R:R:V127	99.9656	4.47	Yes	No	0	7	8
9	R:R:V127	R:R:W151	49.4837	6.13	No	Yes	0	8	5
10	R:R:S131	R:R:W151	10.3166	2.47	No	Yes	0	7	5
11	R:R:D155	R:R:V127	83.2731	5.84	No	No	0	8	8
12	R:R:W367	R:R:Y370	15.5739	7.72	Yes	Yes	0	6	7
13	R:R:I93	R:R:M121	14.507	1.46	No	No	0	3	7
14	R:R:M121	R:R:N92	20.401	7.01	No	Yes	0	7	9
15	R:R:D120	R:R:N92	43.5467	13.46	Yes	Yes	1	9	9
16	R:R:T381	R:R:V95	31.6899	3.17	Yes	No	0	7	9
17	R:R:A117	R:R:V95	42.7379	1.7	No	No	0	9	9
18	R:R:A117	R:R:N92	44.5104	1.56	No	Yes	0	9	9
19	R:R:T381	R:R:Y387	22.2939	4.99	Yes	Yes	0	7	8
20	R:R:V95	R:R:V99	10.5748	1.6	No	No	0	9	7
21	R:R:F112	R:R:H165	32.3008	10.18	Yes	Yes	0	8	8
22	R:R:H165	R:R:V199	39.0122	6.92	Yes	No	0	8	6
23	R:R:M164	R:R:V199	41.1289	3.04	No	No	0	6	6
24	R:R:M164	R:R:T160	43.2112	3.01	No	No	0	6	7
25	R:R:S242	R:R:T160	48.4168	3.2	No	No	0	6	7
26	L:L:?1	R:R:S242	49.5182	4.64	Yes	No	0	0	6
27	R:R:F112	R:R:K195	28.6095	6.2	Yes	No	0	8	6
28	R:R:F158	R:R:L123	30.5799	10.96	Yes	Yes	0	7	7
29	R:R:W141	R:R:W151	34.6154	2.81	Yes	Yes	0	7	5
30	R:R:P142	R:R:W141	16.2364	1.35	No	Yes	0	3	7
31	R:R:P142	R:R:Y137	14.266	8.34	No	No	0	3	4
32	R:R:G138	R:R:Y137	12.2784	1.45	No	No	0	5	4
33	R:R:G138	R:R:Y139	10.2736	2.9	No	No	0	5	3
34	R:R:A149	R:R:L215	10.2306	3.15	No	No	0	6	5
35	R:R:A149	R:R:P211	12.2268	1.87	No	No	0	6	5
36	R:R:I210	R:R:P211	12.1063	8.47	No	No	0	6	5
37	R:R:I210	R:R:L229	10.6952	4.28	No	No	6	6	4
38	R:R:L229	R:R:V235	14.3177	2.98	No	No	0	4	6
39	R:R:N343	R:R:V235	21.3474	4.43	No	No	0	7	6
40	L:L:?1	R:R:N343	23.0081	2.83	Yes	No	0	0	7
41	R:R:F158	R:R:L157	23.4211	3.65	Yes	No	0	7	6
42	R:R:L157	R:R:S207	19.9105	7.51	No	No	0	6	7
43	R:R:S207	R:R:Y153	18.1638	5.09	No	No	0	7	6
44	R:R:P211	R:R:Y153	15.1179	12.52	No	No	0	5	6
45	R:R:M208	R:R:Y153	10.9189	3.59	No	No	0	4	6
46	R:R:F332	R:R:L166	59.069	2.44	No	No	0	9	8
47	R:R:L166	R:R:N376	52.2543	8.24	No	Yes	1	8	9
48	R:R:F332	R:R:M250	57.8988	7.46	No	Yes	0	9	8
49	R:R:M250	R:R:S170	25.9766	3.07	Yes	No	0	8	9
50	R:R:S170	R:R:T253	24.6515	6.4	No	No	0	9	5
51	R:R:D172	R:R:K195	28.2051	6.91	No	No	0	9	6
52	R:R:D172	R:R:H183	28.0589	1.26	No	No	0	9	7
53	R:R:H183	R:R:V175	27.8868	1.38	No	No	0	7	5
54	R:R:V175	R:R:Y174	28.1019	1.26	No	Yes	0	5	8
55	R:R:Q178	R:R:Y174	20.0396	6.76	No	Yes	0	6	8
56	R:R:T257	R:R:Y174	14.2402	4.99	No	Yes	0	9	8
57	R:R:C322	R:R:L261	25.0129	3.17	No	Yes	0	7	8
58	R:R:C322	R:R:I258	27.4393	3.27	No	Yes	0	7	5
59	R:R:I258	R:R:Y254	23.8599	12.09	Yes	No	0	5	9
60	R:R:F329	R:R:Y254	26.3638	15.47	No	No	0	8	9
61	R:R:F329	R:R:M250	32.6708	3.73	No	Yes	0	8	8
62	R:R:H182	R:R:N179	10.2306	3.83	No	No	0	5	6
63	R:R:N179	R:R:Q178	14.2058	1.32	No	No	0	6	6
64	L:L:?1	R:R:F340	37.1623	15.06	Yes	Yes	2	0	7
65	R:R:F240	R:R:F244	13.1905	3.22	No	No	0	4	5
66	R:R:F243	R:R:F244	15.333	6.43	Yes	No	0	8	5
67	R:R:F243	R:R:F340	21.9411	21.43	Yes	Yes	2	8	7
68	L:L:?1	R:R:F339	35.1144	15.06	Yes	Yes	2	0	7
69	R:R:F339	R:R:W336	13.0356	3.01	Yes	Yes	2	7	8
70	R:R:F340	R:R:W336	11.2975	3.01	Yes	Yes	2	7	8
71	R:R:E318	R:R:L261	17.8197	2.65	Yes	Yes	0	8	8
72	R:R:F383	R:R:V324	18.551	3.93	No	No	0	7	8
73	R:R:V324	R:R:V328	20.5386	1.6	No	No	0	8	8
74	R:R:M335	R:R:S372	11.9171	10.73	No	No	0	8	9
75	R:R:S372	R:R:W336	15.8579	2.47	No	Yes	0	9	8
76	R:R:F365	R:R:T342	13.07	9.08	No	No	0	5	5
77	R:R:L362	R:R:T342	23.533	4.42	No	No	0	3	5
78	R:R:F339	R:R:L362	25.3829	2.44	Yes	No	0	7	3
79	R:R:F383	R:R:L382	10.4887	1.22	No	No	0	7	5
80	R:R:N92	R:R:P377	19.0587	4.89	Yes	No	1	9	9
81	R:R:T253	R:R:Y174	22.3542	4.99	No	Yes	0	5	8
82	L:L:?1	R:R:D155	73.662	16.79	Yes	No	2	0	8
83	R:R:I258	R:R:T257	12.6742	3.04	Yes	No	5	5	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D155	R:R:V127	5.84	2	No	No	8	8	1	2
R:R:D155	R:R:Y370	10.34	2	No	Yes	8	7	1	1
L:L:?1	R:R:D155	16.79	2	Yes	No	0	8	0	1
L:L:?1	R:R:V156	10.75	2	Yes	No	0	6	0	1
L:L:?1	R:R:S159	7.74	2	Yes	No	0	7	0	1
R:R:S242	R:R:T160	3.2	0	No	No	6	7	1	2
R:R:N343	R:R:V235	4.43	0	No	No	7	6	1	2
R:R:F340	R:R:S239	6.61	2	Yes	No	7	6	1	2
L:L:?1	R:R:S242	4.64	2	Yes	No	0	6	0	1
R:R:F243	R:R:W336	3.01	2	Yes	Yes	8	8	2	2
R:R:F243	R:R:F340	21.43	2	Yes	Yes	8	7	2	1
R:R:F339	R:R:W336	3.01	2	Yes	Yes	7	8	1	2
R:R:F340	R:R:W336	3.01	2	Yes	Yes	7	8	1	2
R:R:F339	R:R:F340	9.65	2	Yes	Yes	7	7	1	1
R:R:F339	R:R:L362	2.44	2	Yes	No	7	3	1	2
L:L:?1	R:R:F339	15.06	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:F340	15.06	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:N343	2.83	2	Yes	No	0	7	0	1
R:R:V366	R:R:Y370	6.31	2	No	Yes	6	7	1	1
L:L:?1	R:R:V366	3.07	2	Yes	No	0	6	0	1
R:R:W367	R:R:Y370	7.72	0	Yes	Yes	6	7	2	1
L:L:?1	R:R:Y370	3.63	2	Yes	Yes	0	7	0	1
R:R:G238	R:R:I237	1.76	0	No	No	6	4	1	2
L:L:?1	R:R:G238	1.76	2	Yes	No	0	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7RAN_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.44
Number of Linked Nodes	243
Number of Links	257
Number of Hubs	27
Number of Links mediated by Hubs	102
Number of Communities	7
Number of Nodes involved in Communities	32
Number of Links involved in Communities	38

Path Summary
Number Of Nodes in MetaPath	84
Number Of Links MetaPath	83
Number of Shortest Paths	30255
Length Of Smallest Path	3
Average Path Length	12.9007
Length of Longest Path	28
Minimum Path Strength	1.215
Average Path Strength	5.45373
Maximum Path Strength	18.245
Minimum Path Correlation	0.7
Average Path Correlation	0.925378
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	51.7444
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.7055
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	3IQ
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	3IQ
Name	(3R)-3-methyl-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,2,3,6-tetrahydropyridin-1-ium
Synonyms
Identifier
Formula	C13 H16 N3
Molecular Weight	214.286
SMILES
PubChem	164575847
Formal Charge	1
Total Atoms	32
Total Chiral Atoms	1
Total Bonds	34
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P28223
Sequence	>7RAN_nogp_Chain_R L L T A V V I I L T I A G N I L V I M A V S L E K K L Q N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G Y R W P L P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N P I H H S R F N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D S K V F K E G S C L L A D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E A T Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T Y R S A F S R Y I Q C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ZMG	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Pimavanserin	-	-	3.4	2024-08-28	10.1021/acs.jmedchem.4c01244
	8V6U	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 171392456	-	chim(NtGi2-Gs-CtGq)/β1/γ2	3	2024-05-29	10.1126/science.adn6354
	8V6U (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 171392456	-		3	2024-05-29	10.1126/science.adn6354
	8UWL	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.8	2024-05-29	10.1126/science.adn6354
	8UWL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-		2.8	2024-05-29	10.1126/science.adn6354
	8JT8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	(R)-IHCH-7179	-	-	2.7	2024-02-28	To be published
	7RAN	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.45	2022-07-06	10.1038/s41586-022-05258-z
	7RAN (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-		3.45	2022-07-06	10.1038/s41586-022-05258-z
	7WC9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 162421364	-	-	2.5	2022-01-26	10.1126/science.abl8615
	7WC8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lumateperone	-	-	2.45	2022-01-26	10.1126/science.abl8615
	7WC7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	-	2.6	2022-01-26	10.1126/science.abl8615
	7WC6	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	2.6	2022-01-26	10.1126/science.abl8615
	7WC5	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	-	3.2	2022-01-26	10.1126/science.abl8615
	7WC4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	-	3.2	2022-01-26	10.1126/science.abl8615
	7VOE	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Aripiprazole	-	-	2.9	2021-12-22	10.1038/s41593-021-00971-w
	7VOD	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Cariprazine	-	-	3.3	2021-12-22	10.1038/s41593-021-00971-w
	6WH4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	10.1016/j.cell.2020.08.024
	6WH4 (Multimeric)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-		3.4	2020-09-23	10.1016/j.cell.2020.08.024
	6WGT	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.4	2020-09-23	10.1016/j.cell.2020.08.024
	6WGT (Multimeric)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-		3.4	2020-09-23	10.1016/j.cell.2020.08.024
	6WHA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.36	2020-09-23	10.1016/j.cell.2020.08.024
	6WHA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-		3.36	2020-09-23	10.1016/j.cell.2020.08.024
	6A94	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Zotepine	-	-	2.9	2019-02-13	10.1038/s41594-018-0180-z
	6A93	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Risperidone	-	-	3	2019-02-13	10.1038/s41594-018-0180-z

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7RAN_nogp.zip

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