psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W151	10.68	Yes	Yes	1	0	5
2	L:L:?1	R:R:D155	25.46	Yes	No	1	0	8
3	L:L:?1	R:R:V156	12.81	Yes	No	0	0	6
4	L:L:?1	R:R:S159	9.39	Yes	No	0	0	7
5	L:L:?1	R:R:L229	3.25	Yes	No	0	0	4
6	L:L:?1	R:R:S242	4.7	Yes	No	0	0	6
7	L:L:?1	R:R:F339	11.43	Yes	Yes	1	0	7
8	L:L:?1	R:R:F340	7.62	Yes	Yes	1	0	7
9	L:L:?1	R:R:N343	3.22	Yes	No	1	0	7
10	L:L:?1	R:R:Y370	5.5	Yes	Yes	1	0	7
11	R:R:L371	R:R:V84	2.98	No	No	0	4	7
12	R:R:I85	R:R:M128	4.37	Yes	Yes	0	6	8
13	R:R:I85	R:R:P129	3.39	Yes	No	0	6	8
14	R:R:I85	R:R:W367	3.52	Yes	Yes	0	6	6
15	R:R:M128	R:R:T88	7.53	Yes	No	0	8	7
16	R:R:A374	R:R:T88	3.36	No	No	0	6	7
17	R:R:D120	R:R:N92	6.73	Yes	No	0	9	9
18	R:R:M121	R:R:N92	4.21	No	No	0	7	9
19	R:R:N92	R:R:P377	11.4	No	No	0	9	9
20	R:R:F391	R:R:L94	3.65	No	No	0	6	6
21	R:R:A117	R:R:V95	3.39	No	Yes	0	9	9
22	R:R:T381	R:R:V95	4.76	No	Yes	0	7	9
23	R:R:N110	R:R:V99	7.39	Yes	No	0	9	7
24	R:R:L105	R:R:N110	5.49	No	Yes	3	8	9
25	R:R:L105	R:R:T386	7.37	No	No	0	8	6
26	R:R:L105	R:R:Y387	7.03	No	Yes	3	8	8
27	R:R:Q106	R:R:Y111	14.65	No	No	0	7	4
28	R:R:A108	R:R:N187	3.13	No	No	0	5	6
29	R:R:N110	R:R:Y387	9.3	Yes	Yes	3	9	8
30	R:R:F112	R:R:H165	9.05	Yes	Yes	2	8	8
31	R:R:F112	R:R:I169	5.02	Yes	No	2	8	9
32	R:R:F112	R:R:K195	9.93	Yes	Yes	0	8	6
33	R:R:F112	R:R:V199	5.24	Yes	No	2	8	6
34	R:R:H165	R:R:S115	8.37	Yes	No	2	8	9
35	R:R:I196	R:R:S115	6.19	No	No	0	8	9
36	R:R:S115	R:R:W200	4.94	No	Yes	2	9	9
37	R:R:D120	R:R:L116	5.43	Yes	No	0	9	9
38	R:R:H165	R:R:L116	10.29	Yes	No	0	8	9
39	R:R:L116	R:R:L166	4.15	No	Yes	0	9	8
40	R:R:D120	R:R:S162	5.89	Yes	No	0	9	9
41	R:R:D120	R:R:S373	10.31	Yes	No	0	9	9
42	R:R:D120	R:R:N376	4.04	Yes	No	0	9	9
43	R:R:F158	R:R:L122	8.53	Yes	No	0	7	7
44	R:R:L123	R:R:V127	4.47	No	Yes	0	7	8
45	R:R:F158	R:R:L123	7.31	Yes	No	0	7	7
46	R:R:L123	R:R:S373	4.5	No	No	0	7	9
47	R:R:G124	R:R:M128	6.99	No	Yes	0	6	8
48	R:R:F158	R:R:L126	3.65	Yes	No	0	7	5
49	R:R:V127	R:R:W151	7.36	Yes	Yes	1	8	5
50	R:R:D155	R:R:V127	7.3	No	Yes	1	8	8
51	R:R:V127	R:R:Y370	3.79	Yes	Yes	1	8	7
52	R:R:M128	R:R:Y370	11.97	Yes	Yes	0	8	7
53	R:R:V130	R:R:W151	12.26	No	Yes	0	4	5
54	R:R:S131	R:R:W151	6.18	No	Yes	1	7	5
55	R:R:S131	R:R:W367	3.71	No	Yes	1	7	6
56	R:R:S131	R:R:Y370	5.09	No	Yes	1	7	7
57	R:R:L133	R:R:Y137	3.52	No	No	0	4	4
58	R:R:I135	R:R:N363	4.25	No	No	0	5	4
59	R:R:L136	R:R:Y137	3.52	No	No	0	5	4
60	R:R:P142	R:R:Y137	6.95	No	No	0	3	4
61	R:R:S226	R:R:Y139	5.09	No	No	0	4	3
62	R:R:N363	R:R:Y139	10.47	No	No	0	4	3
63	R:R:C148	R:R:W141	6.53	No	Yes	1	9	7
64	R:R:W141	R:R:W151	12.18	Yes	Yes	1	7	5
65	R:R:C227	R:R:W141	10.45	Yes	Yes	1	9	7
66	R:R:L147	R:R:V150	4.47	No	No	0	5	4
67	R:R:C148	R:R:F222	6.98	No	No	0	9	2
68	R:R:C148	R:R:C227	7.28	No	Yes	1	9	9
69	R:R:A149	R:R:F222	4.16	No	No	0	6	2
70	R:R:C227	R:R:W151	3.92	Yes	Yes	1	9	5
71	R:R:I152	R:R:V221	3.07	No	No	0	5	3
72	R:R:C227	R:R:I152	3.27	Yes	No	0	9	5
73	R:R:L157	R:R:Y153	3.52	Yes	No	4	6	6
74	R:R:S207	R:R:Y153	5.09	No	No	4	7	6
75	R:R:P211	R:R:Y153	11.13	No	No	0	5	6
76	R:R:D155	R:R:Y370	8.05	No	Yes	1	8	7
77	R:R:S207	R:R:V156	3.23	No	No	0	7	6
78	R:R:I210	R:R:V156	4.61	No	No	0	6	6
79	R:R:F158	R:R:L157	6.09	Yes	Yes	0	7	6
80	R:R:L157	R:R:V204	2.98	Yes	No	0	6	4
81	R:R:L157	R:R:S207	6.01	Yes	No	4	6	7
82	R:R:S242	R:R:T160	7.99	No	No	0	6	7
83	R:R:A161	R:R:W200	7.78	No	Yes	2	8	9
84	R:R:A161	R:R:S203	3.42	No	No	2	8	8
85	R:R:I163	R:R:P246	3.39	No	Yes	0	8	9
86	R:R:F332	R:R:I163	3.77	Yes	No	1	9	8
87	R:R:I163	R:R:W336	3.52	No	Yes	1	8	8
88	R:R:M164	R:R:P246	5.03	No	Yes	0	6	9
89	R:R:H165	R:R:V199	9.69	Yes	No	2	8	6
90	R:R:H165	R:R:W200	7.41	Yes	Yes	2	8	9
91	R:R:F332	R:R:L166	3.65	Yes	Yes	0	9	8
92	R:R:L166	R:R:N376	6.87	Yes	No	0	8	9
93	R:R:L166	R:R:Y380	10.55	Yes	Yes	0	8	9
94	R:R:C167	R:R:P246	3.77	No	Yes	0	6	9
95	R:R:C167	R:R:I249	4.91	No	No	0	6	6
96	R:R:A168	R:R:K195	3.21	No	Yes	0	7	6
97	R:R:I169	R:R:R173	5.01	No	No	2	9	9
98	R:R:I169	R:R:Y380	6.04	No	Yes	2	9	9
99	R:R:M250	R:R:S170	3.07	No	No	0	8	9
100	R:R:S170	R:R:T253	6.4	No	No	0	9	5
101	R:R:I249	R:R:L171	4.28	No	No	0	6	6
102	R:R:L171	R:R:T253	2.95	No	No	0	6	5
103	R:R:D172	R:R:H183	5.04	No	Yes	0	9	7
104	R:R:L325	R:R:R173	4.86	No	No	0	8	9
105	R:R:R173	R:R:Y380	4.12	No	Yes	2	9	9
106	R:R:Q178	R:R:Y174	12.4	No	No	0	6	8
107	R:R:L256	R:R:Y174	5.86	Yes	No	0	5	8
108	R:R:T257	R:R:Y174	4.99	No	No	0	9	8
109	R:R:N179	R:R:V175	2.96	No	No	0	6	5
110	R:R:A176	R:R:H183	7.32	No	Yes	0	8	7
111	R:R:I177	R:R:T257	4.56	No	No	0	9	9
112	R:R:N179	R:R:Q178	5.28	No	No	0	6	6
113	R:R:Q178	R:R:S260	8.66	No	No	0	6	6
114	R:R:H182	R:R:R185	11.28	No	No	0	5	4
115	R:R:S188	R:R:T190	3.2	No	No	0	7	5
116	R:R:K191	R:R:K195	5.75	No	Yes	0	6	6
117	R:R:V199	R:R:W200	3.68	No	Yes	2	6	9
118	R:R:S203	R:R:W200	7.41	No	Yes	2	8	9
119	R:R:I206	R:R:V241	3.07	No	No	0	6	4
120	R:R:I210	R:R:P211	5.08	No	No	0	6	5
121	R:R:F234	R:R:I210	5.02	Yes	No	0	7	6
122	R:R:G214	R:R:V221	3.68	No	No	0	7	3
123	R:R:D218	R:R:S219	5.89	No	No	0	3	3
124	R:R:D218	R:R:F222	4.78	No	No	0	3	2
125	R:R:D231	R:R:K220	12.44	No	No	0	5	3
126	R:R:L229	R:R:V221	5.96	No	No	0	4	3
127	R:R:G225	R:R:K223	5.23	No	No	0	3	3
128	R:R:A230	R:R:E224	6.03	No	No	0	3	2
129	R:R:L228	R:R:S226	3	No	No	0	4	4
130	R:R:F234	R:R:L229	6.09	Yes	No	0	7	4
131	R:R:D231	R:R:D232	3.99	No	No	0	5	4
132	R:R:D231	R:R:F234	7.17	No	Yes	0	5	7
133	R:R:D232	R:R:N233	4.04	No	No	0	4	3
134	R:R:F234	R:R:G238	3.01	Yes	No	0	7	6
135	R:R:N343	R:R:V235	2.96	No	No	0	7	6
136	R:R:F340	R:R:S239	3.96	Yes	No	0	7	6
137	R:R:I344	R:R:S239	3.1	No	No	0	5	6
138	R:R:F240	R:R:F244	3.22	No	No	0	4	5
139	R:R:F240	R:R:I245	8.79	No	No	0	4	5
140	R:R:F243	R:R:F244	6.43	Yes	No	0	8	5
141	R:R:F243	R:R:L247	4.87	Yes	No	0	8	6
142	R:R:F243	R:R:F332	4.29	Yes	Yes	1	8	9
143	R:R:F243	R:R:W336	3.01	Yes	Yes	1	8	8
144	R:R:C337	R:R:F243	5.59	No	Yes	0	6	8
145	R:R:F243	R:R:F340	24.65	Yes	Yes	1	8	7
146	R:R:I245	R:R:P246	3.39	No	Yes	0	5	9
147	R:R:F332	R:R:M250	8.71	Yes	No	0	9	8
148	R:R:I258	R:R:Y254	10.88	Yes	No	0	5	9
149	R:R:G326	R:R:Y254	4.35	No	No	0	6	9
150	R:R:F329	R:R:Y254	14.44	No	No	0	8	9
151	R:R:F255	R:R:L256	3.65	No	Yes	0	1	5
152	R:R:L325	R:R:T257	2.95	No	No	0	8	9
153	R:R:C322	R:R:I258	3.27	No	Yes	0	7	5
154	R:R:E318	R:R:L261	5.3	No	Yes	0	8	8
155	R:R:C322	R:R:L261	6.35	No	Yes	0	7	8
156	R:R:E318	R:R:I315	10.93	No	No	0	8	5
157	R:R:K323	R:R:Q319	6.78	No	No	0	7	5
158	R:R:F383	R:R:V324	5.24	No	No	0	7	8
159	R:R:V328	R:R:Y380	6.31	No	Yes	0	8	9
160	R:R:F329	R:R:V333	5.24	No	No	0	8	6
161	R:R:F330	R:R:L331	3.65	No	No	0	5	6
162	R:R:F330	R:R:V334	10.49	No	No	0	5	5
163	R:R:F332	R:R:W336	4.01	Yes	Yes	1	9	8
164	R:R:M335	R:R:V334	3.04	Yes	No	0	8	5
165	R:R:M335	R:R:S372	4.6	Yes	No	0	8	9
166	R:R:F340	R:R:W336	4.01	Yes	Yes	1	7	8
167	R:R:G369	R:R:W336	8.44	No	Yes	0	7	8
168	R:R:S372	R:R:W336	4.94	No	Yes	0	9	8
169	R:R:F339	R:R:F340	7.5	Yes	Yes	1	7	7
170	R:R:F339	R:R:N343	9.67	Yes	No	1	7	7
171	R:R:F339	R:R:V366	3.93	Yes	No	0	7	6
172	R:R:L362	R:R:T342	5.9	No	No	0	3	5
173	R:R:F365	R:R:T342	9.08	No	No	0	5	5
174	R:R:N354	R:R:V357	2.96	No	No	0	1	5
175	R:R:F365	R:R:L361	6.09	No	No	0	5	4
176	R:R:V366	R:R:Y370	6.31	No	Yes	0	6	7
177	R:R:W367	R:R:Y370	16.4	Yes	Yes	1	6	7
178	R:R:N376	R:R:S372	5.96	No	No	0	9	9
179	R:R:V375	R:R:V379	4.81	No	No	0	6	8
180	R:R:T381	R:R:Y387	14.98	No	Yes	0	7	8
181	R:R:F391	R:R:L382	4.87	No	No	0	6	5
182	R:R:N384	R:R:T386	10.24	No	No	0	9	6
183	R:R:N384	R:R:Y387	8.14	No	Yes	0	9	8
184	R:R:K385	R:R:R388	7.43	No	No	0	5	9
185	R:R:I85	R:R:I89	2.94	Yes	No	0	6	5
186	R:R:I89	R:R:I93	2.94	No	No	0	5	3
187	R:R:I202	R:R:I206	2.94	No	No	0	5	6
188	R:R:A119	R:R:H165	2.93	No	Yes	0	8	8
189	R:R:I85	R:R:M132	2.92	Yes	No	0	6	6
190	R:R:I96	R:R:M121	2.92	No	No	0	6	7
191	R:R:I202	R:R:M164	2.92	No	No	0	5	6
192	R:R:I368	R:R:M335	2.92	No	Yes	0	7	8
193	R:R:G138	R:R:Y139	2.9	No	No	0	5	3
194	R:R:F365	R:R:P338	2.89	No	No	0	5	9
195	R:R:I177	R:R:L261	2.85	No	Yes	0	9	8
196	R:R:I252	R:R:L256	2.85	No	Yes	0	5	5
197	R:R:I258	R:R:L325	2.85	Yes	No	0	5	8
198	R:R:L371	R:R:M335	2.83	No	Yes	0	4	8
199	R:R:K191	R:R:N187	2.8	No	No	0	6	6
200	R:R:L126	R:R:L154	2.77	No	No	0	5	5
201	R:R:D172	R:R:K195	2.77	No	Yes	0	9	6
202	R:R:H183	R:R:V175	2.77	Yes	No	0	7	5
203	R:R:A98	R:R:Y387	2.67	No	Yes	0	7	8
204	R:R:E224	R:R:L228	2.65	No	No	0	2	4
205	R:R:F391	R:R:V95	2.62	No	Yes	0	6	9
206	R:R:F329	R:R:V251	2.62	No	No	0	8	5
207	R:R:V99	R:R:Y111	2.52	No	No	0	7	4
208	R:R:V379	R:R:Y380	2.52	No	Yes	0	8	9
209	R:R:I181	R:R:R185	2.51	No	No	0	7	4
210	R:R:F339	R:R:L362	2.44	Yes	No	0	7	3
211	R:R:T134	R:R:W141	2.43	No	Yes	0	5	7
212	R:R:L382	R:R:R388	2.43	No	No	0	5	9
213	R:R:I135	R:R:W367	2.35	No	Yes	0	5	6
214	R:R:G205	R:R:V204	1.84	No	No	0	4	4
215	R:R:A390	R:R:A98	1.79	No	No	0	7	7
216	R:R:A108	R:R:A192	1.79	No	No	0	5	7
217	R:R:P377	R:R:V95	1.77	No	Yes	0	9	9
218	R:R:G238	R:R:I237	1.76	No	No	0	6	4
219	R:R:G205	R:R:M208	1.75	No	No	0	4	4
220	R:R:A390	R:R:S389	1.71	No	No	0	7	4
221	R:R:M208	R:R:P209	1.68	No	No	0	4	7
222	R:R:L215	R:R:P211	1.64	No	No	0	5	5
223	R:R:C337	R:R:I341	1.64	No	No	0	6	6
224	R:R:N179	R:R:P180	1.63	No	No	0	6	8
225	R:R:A346	R:R:I358	1.62	No	No	0	4	4
226	R:R:V324	R:R:V328	1.6	No	No	0	8	8
227	R:R:A374	R:R:L87	1.58	No	No	0	6	4
228	R:R:A321	R:R:L261	1.58	No	Yes	0	8	8
229	R:R:I368	R:R:V364	1.54	No	No	0	7	4
230	R:R:M114	R:R:V99	1.52	No	No	0	5	7
231	R:R:I197	R:R:T201	1.52	No	No	0	2	4
232	R:R:I245	R:R:T248	1.52	No	No	0	5	3
233	R:R:I252	R:R:T248	1.52	No	No	0	5	3
234	R:R:I358	R:R:T342	1.52	No	No	0	4	5
235	R:R:L215	R:R:V150	1.49	No	No	0	5	4
236	R:R:L361	R:R:V357	1.49	No	No	0	4	5
237	R:R:I118	R:R:I96	1.47	No	No	0	6	6
238	R:R:L113	R:R:T381	1.47	No	No	0	8	7
239	R:R:D232	R:R:V347	1.46	No	No	0	4	5
240	R:R:D172	R:R:T109	1.45	No	No	0	9	8
241	R:R:I344	R:R:L236	1.43	No	No	0	5	6
242	R:R:I327	R:R:L331	1.43	No	No	0	6	6
243	R:R:L94	R:R:M97	1.41	No	No	0	6	4
244	R:R:K259	R:R:L256	1.41	No	Yes	0	4	5
245	R:R:H183	R:R:S184	1.39	Yes	No	0	7	6
246	R:R:D217	R:R:K220	1.38	No	No	0	4	3
247	R:R:L378	R:R:L382	1.38	No	No	0	6	5
248	R:R:I258	R:R:Q262	1.37	Yes	No	0	5	6
249	R:R:N107	R:R:N110	1.36	No	Yes	0	7	9
250	R:R:P142	R:R:W141	1.35	No	Yes	0	3	7
251	R:R:F213	R:R:V212	1.31	No	No	0	4	5
252	R:R:D356	R:R:E355	1.3	No	No	0	2	3
253	R:R:F125	R:R:I89	1.26	No	No	0	4	5
254	R:R:D217	R:R:F213	1.19	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.406	10	1	0
2	R:R:I85	3.428	5	0	6
3	R:R:V95	3.135	4	0	9
4	R:R:N110	5.885	4	3	9
5	R:R:F112	7.31	4	2	8
6	R:R:D120	6.48	5	0	9
7	R:R:V127	5.73	4	1	8
8	R:R:M128	7.715	4	0	8
9	R:R:W141	6.588	5	1	7
10	R:R:W151	8.76333	6	1	5
11	R:R:L157	4.65	4	4	6
12	R:R:F158	6.395	4	0	7
13	R:R:H165	7.95667	6	2	8
14	R:R:L166	6.305	4	0	8
15	R:R:H183	4.13	4	0	7
16	R:R:K195	5.415	4	0	6
17	R:R:W200	6.244	5	2	9
18	R:R:C227	6.23	4	1	9
19	R:R:F234	5.3225	4	0	7
20	R:R:F243	8.14	6	1	8
21	R:R:P246	3.895	4	0	9
22	R:R:L256	3.4425	4	0	5
23	R:R:I258	4.5925	4	0	5
24	R:R:L261	4.02	4	0	8
25	R:R:F332	4.886	5	1	9
26	R:R:M335	3.3475	4	0	8
27	R:R:W336	4.655	6	1	8
28	R:R:F339	6.994	5	1	7
29	R:R:F340	9.548	5	1	7
30	R:R:W367	6.495	4	1	6
31	R:R:Y370	8.15857	7	1	7
32	R:R:Y380	5.908	5	2	9
33	R:R:Y387	8.424	5	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F340	100	7.62	Yes	Yes	1	0	7
2	R:R:F340	R:R:W336	73.7811	4.01	Yes	Yes	1	7	8
3	R:R:S372	R:R:W336	25.2683	4.94	No	Yes	0	9	8
4	R:R:M335	R:R:S372	18.4836	4.6	Yes	No	0	8	9
5	L:L:?1	R:R:Y370	45.4538	5.5	Yes	Yes	1	0	7
6	R:R:M128	R:R:Y370	24.218	11.97	Yes	Yes	0	8	7
7	R:R:I85	R:R:M128	12.2968	4.37	Yes	Yes	0	6	8
8	R:R:W367	R:R:Y370	28.8945	16.4	Yes	Yes	1	6	7
9	R:R:I85	R:R:W367	13.1785	3.52	Yes	Yes	0	6	6
10	L:L:?1	R:R:W151	35.6026	10.68	Yes	Yes	1	0	5
11	R:R:V127	R:R:W151	20.3082	7.36	Yes	Yes	1	8	5
12	R:R:L123	R:R:V127	49.6167	4.47	No	Yes	0	7	8
13	R:R:L123	R:R:S373	55.3051	4.5	No	No	0	7	9
14	R:R:D120	R:R:S373	55.3971	10.31	Yes	No	0	9	9
15	R:R:V127	R:R:Y370	24.563	3.79	Yes	Yes	1	8	7
16	R:R:N376	R:R:S372	25.4983	5.96	No	No	0	9	9
17	R:R:D120	R:R:N376	37.6955	4.04	Yes	No	0	9	9
18	R:R:D120	R:R:N92	77.2232	6.73	Yes	No	0	9	9
19	R:R:N92	R:R:P377	67.8013	11.4	No	No	0	9	9
20	R:R:P377	R:R:V95	65.2484	1.77	No	Yes	0	9	9
21	R:R:F391	R:R:V95	19.0432	2.62	No	Yes	0	6	9
22	R:R:T381	R:R:V95	42.7016	4.76	No	Yes	0	7	9
23	R:R:T381	R:R:Y387	38.0558	14.98	No	Yes	0	7	8
24	R:R:N110	R:R:Y387	16.4673	9.3	Yes	Yes	3	9	8
25	R:R:N110	R:R:V99	11.3692	7.39	Yes	No	0	9	7
26	R:R:F243	R:R:F340	51.7249	24.65	Yes	Yes	1	8	7
27	R:R:F243	R:R:F332	43.6369	4.29	Yes	Yes	1	8	9
28	R:R:F332	R:R:L166	89.4434	3.65	Yes	Yes	0	9	8
29	R:R:L116	R:R:L166	36.5455	4.15	No	Yes	0	9	8
30	R:R:H165	R:R:L116	37.7108	10.29	Yes	No	0	8	9
31	R:R:F112	R:R:H165	26.1653	9.05	Yes	Yes	2	8	8
32	R:R:F112	R:R:K195	34.7056	9.93	Yes	Yes	0	8	6
33	R:R:K191	R:R:K195	11.8675	5.75	No	Yes	0	6	6
34	R:R:F332	R:R:W336	38.6231	4.01	Yes	Yes	1	9	8
35	R:R:L166	R:R:Y380	85.3036	10.55	Yes	Yes	0	8	9
36	R:R:I169	R:R:Y380	13.9911	6.04	No	Yes	2	9	9
37	R:R:F112	R:R:I169	16.0917	5.02	Yes	No	2	8	9
38	R:R:F158	R:R:L123	22.5314	7.31	Yes	No	0	7	7
39	L:L:?1	R:R:V156	20.9982	12.81	Yes	No	0	0	6
40	R:R:S207	R:R:V156	10.6869	3.23	No	No	0	7	6
41	R:R:F158	R:R:L157	13.3011	6.09	Yes	Yes	0	7	6
42	R:R:W141	R:R:W151	23.4284	12.18	Yes	Yes	1	7	5
43	R:R:I135	R:R:W367	17.3336	2.35	No	Yes	0	5	6
44	R:R:I135	R:R:N363	15.4401	4.25	No	No	0	5	4
45	R:R:N363	R:R:Y139	13.5541	10.47	No	No	0	4	3
46	R:R:C148	R:R:W141	11.0319	6.53	No	Yes	1	9	7
47	R:R:C227	R:R:W151	15.2791	3.92	Yes	Yes	1	9	5
48	R:R:C148	R:R:C227	11.4152	7.28	No	Yes	1	9	9
49	R:R:C148	R:R:F222	17.9929	6.98	No	No	0	9	2
50	L:L:?1	R:R:L229	42.9163	3.25	Yes	No	0	0	4
51	R:R:L157	R:R:V204	10.5719	2.98	Yes	No	0	6	4
52	R:R:I163	R:R:W336	22.0868	3.52	No	Yes	1	8	8
53	R:R:I163	R:R:P246	30.5888	3.39	No	Yes	0	8	9
54	R:R:M164	R:R:P246	10.4799	5.03	No	Yes	0	6	9
55	R:R:R173	R:R:Y380	59.3836	4.12	No	Yes	2	9	9
56	R:R:F332	R:R:M250	11.2542	8.71	Yes	No	0	9	8
57	R:R:D172	R:R:K195	18.5143	2.77	No	Yes	0	9	6
58	R:R:D172	R:R:H183	13.3701	5.04	No	Yes	0	9	7
59	R:R:L325	R:R:R173	61.5839	4.86	No	No	0	8	9
60	R:R:F243	R:R:F244	13.7918	6.43	Yes	No	0	8	5
61	R:R:F240	R:R:F244	11.6375	3.22	No	No	0	4	5
62	R:R:I245	R:R:T248	20.8908	1.52	No	No	0	5	3
63	R:R:I252	R:R:T248	17.9853	1.52	No	No	0	5	3
64	R:R:I252	R:R:L256	15.3634	2.85	No	Yes	0	5	5
65	R:R:L256	R:R:Y174	12.9715	5.86	Yes	No	0	5	8
66	R:R:Q178	R:R:Y174	16.9043	12.4	No	No	0	6	8
67	R:R:I245	R:R:P246	14.4741	3.39	No	Yes	0	5	9
68	R:R:L325	R:R:T257	29.4542	2.95	No	No	0	8	9
69	R:R:T257	R:R:Y174	16.0304	4.99	No	No	0	9	8
70	R:R:I177	R:R:T257	13.3165	4.56	No	No	0	9	9
71	R:R:F234	R:R:L229	33.847	6.09	Yes	No	0	7	4
72	R:R:D231	R:R:F234	26.5256	7.17	No	Yes	0	5	7
73	R:R:D231	R:R:K220	13.6998	12.44	No	No	0	5	3
74	R:R:I258	R:R:L325	32.2524	2.85	Yes	No	0	5	8
75	R:R:I258	R:R:Y254	14.2134	10.88	Yes	No	0	5	9
76	R:R:C322	R:R:I258	13.4085	3.27	No	Yes	0	7	5
77	R:R:I177	R:R:L261	10.5412	2.85	No	Yes	0	9	8
78	R:R:E318	R:R:L261	10.4952	5.3	No	Yes	0	8	8
79	R:R:C322	R:R:L261	10.7482	6.35	No	Yes	0	7	8
80	R:R:F339	R:R:L362	25.575	2.44	Yes	No	0	7	3
81	R:R:L362	R:R:T342	23.2061	5.9	No	No	0	3	5
82	R:R:F365	R:R:T342	14.5968	9.08	No	No	0	5	5
83	R:R:F391	R:R:L382	11.0856	4.87	No	No	0	6	5
84	R:R:I85	R:R:I89	12.5958	2.94	Yes	No	0	6	5
85	R:R:D217	R:R:K220	10.2959	1.38	No	No	0	4	3
86	R:R:D120	R:R:L116	37.8871	5.43	Yes	No	0	9	9
87	R:R:F339	R:R:F340	22.2248	7.5	Yes	Yes	1	7	7
88	R:R:L166	R:R:N376	23.3441	6.87	Yes	No	0	8	9
89	R:R:F332	R:R:I163	10.8479	3.77	Yes	No	1	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:W151	10.68	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:D155	25.46	1	Yes	No	0	8	0	1
L:L:?1	R:R:V156	12.81	1	Yes	No	0	6	0	1
L:L:?1	R:R:S159	9.39	1	Yes	No	0	7	0	1
L:L:?1	R:R:L229	3.25	1	Yes	No	0	4	0	1
L:L:?1	R:R:S242	4.7	1	Yes	No	0	6	0	1
L:L:?1	R:R:F339	11.43	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F340	7.62	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N343	3.22	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y370	5.5	1	Yes	Yes	0	7	0	1
R:R:V127	R:R:W151	7.36	1	Yes	Yes	8	5	2	1
R:R:D155	R:R:V127	7.3	1	No	Yes	8	8	1	2
R:R:V127	R:R:Y370	3.79	1	Yes	Yes	8	7	2	1
R:R:M128	R:R:Y370	11.97	0	Yes	Yes	8	7	2	1
R:R:V130	R:R:W151	12.26	0	No	Yes	4	5	2	1
R:R:S131	R:R:W151	6.18	1	No	Yes	7	5	2	1
R:R:S131	R:R:W367	3.71	1	No	Yes	7	6	2	2
R:R:S131	R:R:Y370	5.09	1	No	Yes	7	7	2	1
R:R:W141	R:R:W151	12.18	1	Yes	Yes	7	5	2	1
R:R:C227	R:R:W141	10.45	1	Yes	Yes	9	7	2	2
R:R:C227	R:R:W151	3.92	1	Yes	Yes	9	5	2	1
R:R:D155	R:R:Y370	8.05	1	No	Yes	8	7	1	1
R:R:S207	R:R:V156	3.23	4	No	No	7	6	2	1
R:R:I210	R:R:V156	4.61	0	No	No	6	6	2	1
R:R:S242	R:R:T160	7.99	0	No	No	6	7	1	2
R:R:F234	R:R:I210	5.02	0	Yes	No	7	6	2	2
R:R:L229	R:R:V221	5.96	0	No	No	4	3	1	2
R:R:F234	R:R:L229	6.09	0	Yes	No	7	4	2	1
R:R:N343	R:R:V235	2.96	1	No	No	7	6	1	2
R:R:F340	R:R:S239	3.96	1	Yes	No	7	6	1	2
R:R:F243	R:R:W336	3.01	1	Yes	Yes	8	8	2	2
R:R:F243	R:R:F340	24.65	1	Yes	Yes	8	7	2	1
R:R:F340	R:R:W336	4.01	1	Yes	Yes	7	8	1	2
R:R:F339	R:R:F340	7.5	1	Yes	Yes	7	7	1	1
R:R:F339	R:R:N343	9.67	1	Yes	No	7	7	1	1
R:R:F339	R:R:V366	3.93	1	Yes	No	7	6	1	2
R:R:V366	R:R:Y370	6.31	0	No	Yes	6	7	2	1
R:R:W367	R:R:Y370	16.4	1	Yes	Yes	6	7	2	1
R:R:F339	R:R:L362	2.44	1	Yes	No	7	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9AS4_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.95
Number of Linked Nodes	226
Number of Links	254
Number of Hubs	33
Number of Links mediated by Hubs	132
Number of Communities	4
Number of Nodes involved in Communities	33
Number of Links involved in Communities	48

Path Summary
Number Of Nodes in MetaPath	90
Number Of Links MetaPath	89
Number of Shortest Paths	40867
Length Of Smallest Path	3
Average Path Length	11.1601
Length of Longest Path	22
Minimum Path Strength	1.25
Average Path Strength	6.20984
Maximum Path Strength	19.2433
Minimum Path Correlation	0.7
Average Path Correlation	0.905382
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	6.25
Average % Of Corr. Nodes	46.5982
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.6479
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	7LD
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	7LD
Name	Lysergic acid diethylamide
Synonyms	N,N-diethyl-(+)-lysergamide
Identifier
Formula	C20 H25 N3 O
Molecular Weight	323.432
SMILES
PubChem	5761
Formal Charge	0
Total Atoms	49
Total Chiral Atoms	2
Total Bonds	52
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P28223
Sequence	>9AS4_nogp_Chain_R V I I L T I A G N I L V I M A V L Q N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G Y R W P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N P I H H S R F N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D S K V F K E G S C L L A D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T Y R S A F S R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6WGT	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WH4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WHA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.36	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WHA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-		3.36	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	8ZMG	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Pimavanserin	-	-	3.4	2024-08-28	doi.org/10.1021/acs.jmedchem.4c01244
	7RAN	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.45	2022-07-06	doi.org/10.1038/s41586-022-05258-z
	7RAN (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-		3.45	2022-07-06	doi.org/10.1038/s41586-022-05258-z
	7VOD	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Cariprazine	-	-	3.3	2021-12-22	doi.org/10.1038/s41593-021-00971-w
	7VOE	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Aripiprazole	-	-	2.9	2021-12-22	doi.org/10.1038/s41593-021-00971-w
	6A93	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Risperidone	-	-	3	2019-02-13	doi.org/10.1038/s41594-018-0180-z
	6A94	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Zotepine	-	-	2.9	2019-02-13	doi.org/10.1038/s41594-018-0180-z
	7WC4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	-	3.2	2022-01-26	doi.org/10.1126/science.abl8615
	7WC5	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	-	3.2	2022-01-26	doi.org/10.1126/science.abl8615
	7WC6	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	2.6	2022-01-26	doi.org/10.1126/science.abl8615
	7WC7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	-	2.6	2022-01-26	doi.org/10.1126/science.abl8615
	7WC8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lumateperone	-	-	2.45	2022-01-26	doi.org/10.1126/science.abl8615
	7WC9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 162421364	-	-	2.5	2022-01-26	doi.org/10.1126/science.abl8615
	8UWL	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.8	2024-05-29	doi.org/10.1126/science.adn6354
	8UWL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-		2.8	2024-05-29	doi.org/10.1126/science.adn6354
	8V6U	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 171392456	-	chim(NtGi2-Gs-CtGq)/β1/γ2	3	2024-05-29	doi.org/10.1126/science.adn6354
	8V6U (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 171392456	-		3	2024-05-29	doi.org/10.1126/science.adn6354
	8JT8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	(R)-IHCH-7179	-	-	2.7	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	9ARX	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	-	3.24	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARY	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.27	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARY (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-		3.27	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARZ	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-	-	3.37	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS0	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS0 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-		3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS1	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-	-	3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS2	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.21	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-		3.21	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS3	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.18	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.06	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS4 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-		3.06	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS5	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-	-	3.34	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS6	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-		3.07	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	-	2.72	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-	-	3.47	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ASA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.12	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ASA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-		3.12	2025-04-02	doi.org/10.1038/s41467-025-57956-7

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