Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 8.361010
2R:R:T81 7.6575456
3R:R:T88 3.9225407
4R:R:N92 4.4225469
5R:R:F112 5.34167628
6R:R:D120 4.328569
7R:R:M121 3.55407
8R:R:V127 5.73418
9R:R:M128 5.288508
10R:R:W141 9.446507
11R:R:L143 4.91667675
12R:R:W151 7.114515
13R:R:Y153 7.4375486
14R:R:D155 7.74418
15R:R:L157 4.6375486
16R:R:F158 6.6975407
17R:R:H165 8.86528
18R:R:Y174 7.035408
19R:R:H183 6.652547
20R:R:W200 4.978529
21R:R:I210 4.344516
22R:R:F222 5.0125402
23R:R:L229 4.412514
24R:R:F234 5.41417
25R:R:L261 3.675408
26R:R:V328 3.0425438
27R:R:F329 8.4825408
28R:R:W336 4.36833618
29R:R:F339 7.492517
30R:R:F340 12.278517
31R:R:F365 4.4025405
32R:R:W367 8.9406
33R:R:Y370 7.258517
34R:R:Y380 6.2725439
35R:R:Y387 8.05833608
36R:R:Y394 5404
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:Y370 73.82924.8YesYes107
2R:R:W367 R:R:Y370 16.17527.72YesYes067
3R:R:M128 R:R:Y370 74.014110.78YesYes087
4R:R:M128 R:R:T88 71.73863.01YesYes087
5R:R:N92 R:R:T88 68.1912.92YesYes097
6L:L:?1 R:R:D155 37.54411.11YesYes108
7R:R:D155 R:R:V127 12.75977.3YesYes188
8R:R:L123 R:R:V127 47.77294.47NoYes078
9R:R:L123 R:R:S373 42.3683NoNo079
10R:R:V127 R:R:Y370 23.86443.79YesYes187
11R:R:S373 R:R:T88 19.17696.4NoYes097
12R:R:M121 R:R:N92 73.15584.21YesYes079
13R:R:D120 R:R:S373 39.51584.42YesNo099
14R:R:D120 R:R:N92 24.03614.04YesYes699
15R:R:I93 R:R:M121 68.34952.92NoYes037
16R:R:I93 R:R:M97 66.72982.92NoNo034
17R:R:M97 R:R:Y394 65.09248.38NoYes044
18R:R:R393 R:R:Y394 60.36533.09NoYes044
19R:R:E102 R:R:R393 58.66642.33NoNo064
20R:R:E102 R:R:L105 53.63127.95NoNo068
21R:R:L105 R:R:Y387 48.56959.38NoYes088
22R:R:A98 R:R:Y387 19.09332.67NoYes078
23R:R:A98 R:R:F391 17.23152.77NoNo076
24R:R:V99 R:R:Y387 16.62413.79NoYes078
25R:R:D120 R:R:L116 38.61364.07YesNo099
26R:R:H165 R:R:L116 35.15859YesNo089
27R:R:F112 R:R:H165 19.744710.18YesYes288
28L:L:?1 R:R:F339 48.516712.46YesYes107
29R:R:F339 R:R:W336 41.90583.01YesYes178
30R:R:S372 R:R:W336 21.9414.94NoYes098
31R:R:N376 R:R:S372 20.6035.96NoNo099
32R:R:N376 R:R:Y380 17.90935.81NoYes399
33R:R:R173 R:R:Y380 11.38647.2NoYes399
34R:R:I169 R:R:R173 13.08986.26NoNo099
35R:R:F112 R:R:I169 13.2136.28YesNo089
36L:L:?1 R:R:F340 73.09428.72YesYes107
37R:R:F340 R:R:W336 39.16374.01YesYes178
38R:R:H165 R:R:W200 17.30638.46YesYes289
39R:R:F158 R:R:L123 16.7656.09YesNo077
40R:R:D155 R:R:W151 33.45073.35YesYes185
41R:R:V130 R:R:W151 16.267611.03NoYes045
42R:R:L143 R:R:V130 14.41462.98YesNo054
43R:R:W141 R:R:W151 46.399610.31YesYes075
44R:R:L143 R:R:W141 14.881211.39YesYes057
45R:R:F222 R:R:W141 18.87325.01YesYes027
46R:R:I210 R:R:P211 12.06873.39YesNo065
47R:R:P211 R:R:Y153 10.827513.91NoYes056
48L:L:?1 R:R:L229 32.57487.08YesYes104
49R:R:S203 R:R:W200 11.64174.94NoYes289
50R:R:F332 R:R:W336 71.07397.02NoYes198
51R:R:F332 R:R:M250 1009.95NoNo098
52R:R:M250 R:R:S170 97.6323.07NoNo089
53R:R:S170 R:R:T253 95.25534.8NoNo095
54R:R:L171 R:R:T253 21.43932.95NoNo065
55R:R:I249 R:R:L171 18.78962.85NoNo066
56R:R:I245 R:R:I249 13.46392.94NoNo056
57R:R:I245 R:R:P246 10.78795.08NoNo059
58R:R:F243 R:R:F340 31.936628.94NoYes187
59R:R:F243 R:R:F332 31.28085.36NoNo189
60R:R:F112 R:R:K195 13.64442.48YesNo086
61R:R:D172 R:R:K195 12.14794.15NoNo096
62R:R:T253 R:R:Y174 73.46832.5NoYes058
63R:R:Q178 R:R:Y174 16.131211.27NoYes068
64R:R:T257 R:R:Y174 48.42434.99NoYes098
65R:R:I177 R:R:T257 43.68844.56NoNo099
66R:R:I177 R:R:L261 41.10485.71NoYes098
67R:R:N179 R:R:Q178 10.78792.64NoNo066
68R:R:F234 R:R:L229 17.14794.87YesYes174
69R:R:F234 R:R:P209 11.31165.78YesNo077
70R:R:L229 R:R:V235 11.82222.98YesNo046
71R:R:V235 R:R:V347 18.45511.6NoNo065
72R:R:L236 R:R:V347 15.03964.47NoNo065
73L:L:?1 R:R:N343 11.60214.22YesNo007
74R:R:C322 R:R:L261 26.31164.76NoYes078
75R:R:C322 R:R:I258 21.02553.27NoNo075
76R:R:I258 R:R:Y254 18.38039.67NoNo059
77R:R:F329 R:R:Y254 13.446318.57YesNo089
78R:R:E318 R:R:L261 10.37412.65NoYes088
79R:R:F339 R:R:L362 14.42343.65YesNo073
80R:R:L362 R:R:T342 12.15232.95NoNo035
81R:R:F391 R:R:L382 11.58013.65NoNo065
82R:R:I348 R:R:L236 11.2941.43NoNo046
83R:R:V127 R:R:W151 30.96397.36YesYes185
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D155 11.11 1 Yes Yes 0 8 0 1
L:L:?1 R:R:V156 13.72 1 Yes No 0 6 0 1
L:L:?1 R:R:S159 12.29 1 Yes No 0 7 0 1
L:L:?1 R:R:L229 7.08 1 Yes Yes 0 4 0 1
L:L:?1 R:R:S242 6.15 1 Yes No 0 6 0 1
L:L:?1 R:R:F339 12.46 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F340 8.72 1 Yes Yes 0 7 0 1
L:L:?1 R:R:N343 4.22 1 Yes No 0 7 0 1
L:L:?1 R:R:V366 3.05 1 Yes No 0 6 0 1
L:L:?1 R:R:Y370 4.8 1 Yes Yes 0 7 0 1
R:R:V127 R:R:W151 7.36 1 Yes Yes 8 5 2 2
R:R:D155 R:R:V127 7.3 1 Yes Yes 8 8 1 2
R:R:V127 R:R:Y370 3.79 1 Yes Yes 8 7 2 1
R:R:M128 R:R:Y370 10.78 0 Yes Yes 8 7 2 1
R:R:I152 R:R:W151 3.52 1 No Yes 5 5 2 2
R:R:D155 R:R:W151 3.35 1 Yes Yes 8 5 1 2
R:R:I152 R:R:I210 4.42 1 No Yes 5 6 2 2
R:R:I152 R:R:L229 2.85 1 No Yes 5 4 2 1
R:R:D155 R:R:Y370 9.2 1 Yes Yes 8 7 1 1
R:R:I210 R:R:V156 4.61 1 Yes No 6 6 2 1
R:R:I210 R:R:L229 4.28 1 Yes Yes 6 4 2 1
R:R:F234 R:R:I210 5.02 1 Yes Yes 7 6 2 2
R:R:F234 R:R:L229 4.87 1 Yes Yes 7 4 2 1
R:R:L229 R:R:V235 2.98 1 Yes No 4 6 1 2
R:R:N343 R:R:V235 5.91 0 No No 7 6 1 2
R:R:F340 R:R:S239 7.93 1 Yes No 7 6 1 2
R:R:F243 R:R:W336 3.01 1 No Yes 8 8 2 2
R:R:F243 R:R:F340 28.94 1 No Yes 8 7 2 1
R:R:F339 R:R:W336 3.01 1 Yes Yes 7 8 1 2
R:R:F340 R:R:W336 4.01 1 Yes Yes 7 8 1 2
R:R:F339 R:R:F340 11.79 1 Yes Yes 7 7 1 1
R:R:F339 R:R:L362 3.65 1 Yes No 7 3 1 2
R:R:F339 R:R:V366 6.55 1 Yes No 7 6 1 1
R:R:W367 R:R:Y370 7.72 0 Yes Yes 6 7 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9AS6_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.85
Number of Linked Nodes 245
Number of Links 269
Number of Hubs 36
Number of Links mediated by Hubs 139
Number of Communities 8
Number of Nodes involved in Communities 43
Number of Links involved in Communities 57
Path Summary
Number Of Nodes in MetaPath 84
Number Of Links MetaPath 83
Number of Shortest Paths 56431
Length Of Smallest Path 3
Average Path Length 14.4363
Length of Longest Path 36
Minimum Path Strength 1.295
Average Path Strength 5.85877
Maximum Path Strength 20.365
Minimum Path Correlation 0.7
Average Path Correlation 0.917152
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.44828
Average % Of Corr. Nodes 39.3774
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.6368
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code_L_
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
Code_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP28223
Sequence
>9AS6_nogp_Chain_R
LLTAVVIIL TIAGNILVI MAVSLEKKL QNATNYFLM SLAIADMLL 
GFLVMPVSM LTILYGYRW PLPSKLCAV WIYLDVLFS TASIMHLCA 
ISLDRYVAI QNPIHHSRF NSRTKAFLK IIAVWTISV GISMPIPVF 
GLQDDSKVF KEGSCLLAD DNFVLIGSF VSFFIPLTI MVITYFLTI 
KSLQKEISN EQKACKVLG IVFFLFVVM WCPFFITNI MAVICNEDV 
IGALLNVFV WIGYLSSAV NPLVYTLFN KTYRSAFSR YI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6A93AAmine5-Hydroxytryptamine5-HT2AHomo sapiensRisperidone--32019-02-13doi.org/10.1038/s41594-018-0180-z
6A94AAmine5-Hydroxytryptamine5-HT2AHomo sapiensZotepine--2.92019-02-13doi.org/10.1038/s41594-018-0180-z
6WGTAAmine5-Hydroxytryptamine5-HT2AHomo sapiensLSD--3.42020-09-23doi.org/10.1016/j.cell.2020.08.024
6WH4AAmine5-Hydroxytryptamine5-HT2AHomo sapiensMethiothepin--3.42020-09-23doi.org/10.1016/j.cell.2020.08.024
6WHAAAmine5-Hydroxytryptamine5-HT2AHomo sapiensDB13948-chim(NtGi2L-Gs-CtGq)/β1/γ23.362020-09-23doi.org/10.1016/j.cell.2020.08.024
6WHA (No Gprot) AAmine5-Hydroxytryptamine5-HT2AHomo sapiensDB13948-3.362020-09-23doi.org/10.1016/j.cell.2020.08.024
7VODAAmine5-Hydroxytryptamine5-HT2AHomo sapiensCariprazine--3.32021-12-22doi.org/10.1038/s41593-021-00971-w
7VOEAAmine5-Hydroxytryptamine5-HT2AHomo sapiensAripiprazole--2.92021-12-22doi.org/10.1038/s41593-021-00971-w
7WC4AAmine5-Hydroxytryptamine5-HT2AHomo sapiensSerotonin--3.22022-01-26doi.org/10.1126/science.abl8615
7WC5AAmine5-Hydroxytryptamine5-HT2AHomo sapiensPsilocin--3.22022-01-26doi.org/10.1126/science.abl8615
7WC6AAmine5-Hydroxytryptamine5-HT2AHomo sapiensLSD--2.62022-01-26doi.org/10.1126/science.abl8615
7WC7AAmine5-Hydroxytryptamine5-HT2AHomo sapiensLisuride--2.62022-01-26doi.org/10.1126/science.abl8615
7WC8AAmine5-Hydroxytryptamine5-HT2AHomo sapiensLumateperone--2.452022-01-26doi.org/10.1126/science.abl8615
7WC9AAmine5-Hydroxytryptamine5-HT2AHomo sapiensPubChem 162421364--2.52022-01-26doi.org/10.1126/science.abl8615
7RANAAmine5-Hydroxytryptamine5-HT2AHomo sapiensPubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ23.452022-07-06doi.org/10.1038/s41586-022-05258-z
7RAN (No Gprot) AAmine5-Hydroxytryptamine5-HT2AHomo sapiensPubChem 164575847-3.452022-07-06doi.org/10.1038/s41586-022-05258-z
8UWLAAmine5-Hydroxytryptamine5-HT2AHomo sapiensLisuride-chim(NtGi2-Gs-CtGq)/β1/γ22.82024-05-29doi.org/10.1126/science.adn6354
8UWL (No Gprot) AAmine5-Hydroxytryptamine5-HT2AHomo sapiensLisuride-2.82024-05-29doi.org/10.1126/science.adn6354
8V6UAAmine5-Hydroxytryptamine5-HT2AHomo sapiensPubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ232024-05-29doi.org/10.1126/science.adn6354
8V6U (No Gprot) AAmine5-Hydroxytryptamine5-HT2AHomo sapiensPubChem 171392456-32024-05-29doi.org/10.1126/science.adn6354
8ZMGAAmine5-Hydroxytryptamine5-HT2AHomo sapiensPimavanserin--3.42024-08-28doi.org/10.1021/acs.jmedchem.4c01244
8JT8AAmine5-Hydroxytryptamine5-HT2AHomo sapiens(R)-IHCH-7179--2.72024-02-28doi.org/10.1016/j.cell.2024.02.034
9ARXAAmine5-Hydroxytryptamine5-HT2AHomo sapiensSerotonin--3.242025-04-02doi.org/10.1038/s41467-025-57956-7
9ARYAAmine5-Hydroxytryptamine5-HT2AHomo sapiensSerotonin-chim(NtGi1-Gs-CtGq)/β1/γ23.272025-04-02doi.org/10.1038/s41467-025-57956-7
9ARY (No Gprot) AAmine5-Hydroxytryptamine5-HT2AHomo sapiensSerotonin-3.272025-04-02doi.org/10.1038/s41467-025-57956-7
9ARZAAmine5-Hydroxytryptamine5-HT2AHomo sapiens2-bromo-LSD--3.372025-04-02doi.org/10.1038/s41467-025-57956-7
9AS0AAmine5-Hydroxytryptamine5-HT2AHomo sapiens2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ23.382025-04-02doi.org/10.1038/s41467-025-57956-7
9AS0 (No Gprot) AAmine5-Hydroxytryptamine5-HT2AHomo sapiens2-bromo-LSD-3.382025-04-02doi.org/10.1038/s41467-025-57956-7
9AS1AAmine5-Hydroxytryptamine5-HT2AHomo sapiensDMT--3.382025-04-02doi.org/10.1038/s41467-025-57956-7
9AS2AAmine5-Hydroxytryptamine5-HT2AHomo sapiensDMT-chim(NtGi1-Gs-CtGq)/β1/γ23.212025-04-02doi.org/10.1038/s41467-025-57956-7
9AS2 (No Gprot) AAmine5-Hydroxytryptamine5-HT2AHomo sapiensDMT-3.212025-04-02doi.org/10.1038/s41467-025-57956-7
9AS3AAmine5-Hydroxytryptamine5-HT2AHomo sapiensLSD--3.182025-04-02doi.org/10.1038/s41467-025-57956-7
9AS4AAmine5-Hydroxytryptamine5-HT2AHomo sapiensLSD-chim(NtGi1-Gs-CtGq)/β1/γ23.062025-04-02doi.org/10.1038/s41467-025-57956-7
9AS4 (No Gprot) AAmine5-Hydroxytryptamine5-HT2AHomo sapiensLSD-3.062025-04-02doi.org/10.1038/s41467-025-57956-7
9AS5AAmine5-Hydroxytryptamine5-HT2AHomo sapiensMescaline--3.342025-04-02doi.org/10.1038/s41467-025-57956-7
9AS6AAmine5-Hydroxytryptamine5-HT2AHomo sapiensMescaline-chim(NtGi1-Gs-CtGq)/β1/γ23.072025-04-02doi.org/10.1038/s41467-025-57956-7
9AS6 (No Gprot) AAmine5-Hydroxytryptamine5-HT2AHomo sapiensMescaline-3.072025-04-02doi.org/10.1038/s41467-025-57956-7
9AS7AAmine5-Hydroxytryptamine5-HT2AHomo sapiensPsilocin--2.722025-04-02doi.org/10.1038/s41467-025-57956-7
9AS9AAmine5-Hydroxytryptamine5-HT2AHomo sapiensRS130-180--3.472025-04-02doi.org/10.1038/s41467-025-57956-7
9ASAAAmine5-Hydroxytryptamine5-HT2AHomo sapiensRS130-180-chim(NtGi1-Gs-CtGq)/β1/γ23.122025-04-02doi.org/10.1038/s41467-025-57956-7
9ASA (No Gprot) AAmine5-Hydroxytryptamine5-HT2AHomo sapiensRS130-180-3.122025-04-02doi.org/10.1038/s41467-025-57956-7
9AS8AAmine5-Hydroxytryptamine5-HT2AHomo sapiensPsilocin-chim(NtGi2L-Gs-CtGq)/β1/γ22.542025-04-0210.1038/s41467-025-57956-7
9AS8 (No Gprot) AAmine5-Hydroxytryptamine5-HT2AHomo sapiensPsilocin-2.542025-04-0210.1038/s41467-025-57956-7
9LL9AAmine5-Hydroxytryptamine5-HT2AHomo sapiensDOI-chim(NtGi1L-Gs-CtGq)/β1/γ22.762026-01-14To be published
9LL9 (No Gprot) AAmine5-Hydroxytryptamine5-HT2AHomo sapiensDOI-2.762026-01-14To be published
9LLAAAmine5-Hydroxytryptamine5-HT2AHomo sapiensAriadne-chim(NtGi1L-Gs-CtGq)/β1/γ23.272026-01-14To be published
9LLA (No Gprot) AAmine5-Hydroxytryptamine5-HT2AHomo sapiensAriadne-3.272026-01-14To be published
9LLBAAmine5-Hydroxytryptamine5-HT2AHomo sapiensDOI-NBOMe-chim(NtGi1L-Gs-CtGq)/β1/γ22.982026-01-14To be published
9LLB (No Gprot) AAmine5-Hydroxytryptamine5-HT2AHomo sapiensDOI-NBOMe-2.982026-01-14To be published
9LL7AAmine5-Hydroxytryptamine5-HT2AHomo sapiensDOI-Gi1/β1/γ22.842026-01-14To be published
9LL7 (No Gprot) AAmine5-Hydroxytryptamine5-HT2AHomo sapiensDOI-2.842026-01-14To be published
9LL8AAmine5-Hydroxytryptamine5-HT2AHomo sapiensPsilocin-Gi1/β1/γ22.622026-01-14To be published
9LL8 (No Gprot) AAmine5-Hydroxytryptamine5-HT2AHomo sapiensPsilocin-2.622026-01-14To be published




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