psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D155	5.93	Yes	Yes	1	0	8
2	L:L:?1	R:R:V156	7.33	Yes	No	0	0	6
3	L:L:?1	R:R:S159	6.56	Yes	No	0	0	7
4	L:L:?1	R:R:L229	3.78	Yes	Yes	1	0	4
5	L:L:?1	R:R:S242	3.28	Yes	No	0	0	6
6	L:L:?1	R:R:F339	6.65	Yes	Yes	1	0	7
7	L:L:?1	R:R:F340	4.66	Yes	Yes	1	0	7
8	R:R:L79	R:R:L80	4.15	No	No	5	4	4
9	R:R:L79	R:R:T81	4.42	No	Yes	5	4	6
10	R:R:L80	R:R:T81	4.42	No	Yes	5	4	6
11	R:R:M132	R:R:T81	6.02	No	Yes	0	6	6
12	R:R:T81	R:R:W367	15.77	Yes	Yes	0	6	6
13	R:R:L87	R:R:V83	2.98	No	No	0	4	4
14	R:R:M128	R:R:V84	3.04	Yes	No	0	8	7
15	R:R:L371	R:R:V84	2.98	No	No	0	4	7
16	R:R:I85	R:R:M128	4.37	No	Yes	0	6	8
17	R:R:I85	R:R:P129	5.08	No	No	0	6	8
18	R:R:N92	R:R:T88	2.92	Yes	Yes	0	9	7
19	R:R:M128	R:R:T88	3.01	Yes	Yes	0	8	7
20	R:R:S373	R:R:T88	6.4	No	Yes	0	9	7
21	R:R:A374	R:R:T88	3.36	No	Yes	0	6	7
22	R:R:I89	R:R:M121	5.83	No	Yes	0	5	7
23	R:R:D120	R:R:N92	4.04	Yes	Yes	6	9	9
24	R:R:M121	R:R:N92	4.21	Yes	Yes	0	7	9
25	R:R:N92	R:R:P377	6.52	Yes	No	6	9	9
26	R:R:I93	R:R:M97	2.92	No	No	0	3	4
27	R:R:I93	R:R:M121	2.92	No	Yes	0	3	7
28	R:R:F391	R:R:L94	7.31	No	No	0	6	6
29	R:R:I395	R:R:L94	7.14	No	No	0	6	6
30	R:R:A117	R:R:V95	3.39	No	No	0	9	9
31	R:R:T381	R:R:V95	3.17	No	No	0	7	9
32	R:R:I96	R:R:M114	4.37	No	No	0	6	5
33	R:R:M97	R:R:Y394	8.38	No	Yes	0	4	4
34	R:R:M114	R:R:V99	9.13	No	No	0	5	7
35	R:R:V99	R:R:Y387	3.79	No	Yes	0	7	8
36	R:R:M114	R:R:S100	3.07	No	No	0	5	1
37	R:R:L101	R:R:Y394	5.86	No	Yes	0	5	4
38	R:R:E102	R:R:L105	7.95	No	No	0	6	8
39	R:R:K103	R:R:K104	10.06	No	No	0	6	6
40	R:R:L105	R:R:T386	2.95	No	No	0	8	6
41	R:R:L105	R:R:Y387	9.38	No	Yes	0	8	8
42	R:R:Q106	R:R:Y111	6.76	No	No	0	7	4
43	R:R:N107	R:R:N110	6.81	No	No	0	7	9
44	R:R:N110	R:R:Y387	9.3	No	Yes	0	9	8
45	R:R:F112	R:R:H165	10.18	Yes	Yes	2	8	8
46	R:R:A168	R:R:F112	4.16	No	Yes	0	7	8
47	R:R:F112	R:R:I169	6.28	Yes	No	0	8	9
48	R:R:F112	R:R:I196	5.02	Yes	No	0	8	8
49	R:R:F112	R:R:V199	3.93	Yes	No	2	8	6
50	R:R:L113	R:R:T381	4.42	No	No	0	8	7
51	R:R:H165	R:R:S115	6.97	Yes	No	2	8	9
52	R:R:I196	R:R:S115	7.74	No	No	0	8	9
53	R:R:S115	R:R:W200	3.71	No	Yes	2	9	9
54	R:R:D120	R:R:L116	4.07	Yes	No	0	9	9
55	R:R:H165	R:R:L116	9	Yes	No	0	8	9
56	R:R:D120	R:R:S162	5.89	Yes	No	0	9	9
57	R:R:D120	R:R:S373	4.42	Yes	No	0	9	9
58	R:R:D120	R:R:P377	3.22	Yes	No	6	9	9
59	R:R:F158	R:R:L122	9.74	Yes	No	0	7	7
60	R:R:L123	R:R:V127	4.47	No	Yes	0	7	8
61	R:R:F158	R:R:L123	6.09	Yes	No	0	7	7
62	R:R:L123	R:R:S373	3	No	No	0	7	9
63	R:R:G124	R:R:M128	5.24	No	Yes	0	6	8
64	R:R:V127	R:R:W151	7.36	Yes	Yes	1	8	5
65	R:R:D155	R:R:V127	7.3	Yes	Yes	1	8	8
66	R:R:V127	R:R:Y370	3.79	Yes	Yes	1	8	7
67	R:R:M128	R:R:Y370	10.78	Yes	Yes	0	8	7
68	R:R:L143	R:R:V130	2.98	Yes	No	0	5	4
69	R:R:V130	R:R:W151	11.03	No	Yes	0	4	5
70	R:R:S131	R:R:W367	7.41	No	Yes	0	7	6
71	R:R:T134	R:R:Y139	4.99	No	No	0	5	3
72	R:R:T134	R:R:W141	4.85	No	Yes	0	5	7
73	R:R:I135	R:R:L136	2.85	No	No	0	5	5
74	R:R:I135	R:R:W367	4.7	No	Yes	0	5	6
75	R:R:P142	R:R:Y137	18.08	No	No	0	3	4
76	R:R:N363	R:R:Y139	11.63	No	No	0	4	3
77	R:R:L143	R:R:W141	11.39	Yes	Yes	0	5	7
78	R:R:C148	R:R:W141	15.67	No	Yes	0	9	7
79	R:R:W141	R:R:W151	10.31	Yes	Yes	0	7	5
80	R:R:F222	R:R:W141	5.01	Yes	Yes	0	2	7
81	R:R:L143	R:R:P142	4.93	Yes	No	0	5	3
82	R:R:L143	R:R:P144	3.28	Yes	No	7	5	7
83	R:R:L143	R:R:L147	5.54	Yes	No	7	5	5
84	R:R:L147	R:R:P144	9.85	No	No	7	5	7
85	R:R:K146	R:R:S145	4.59	No	No	0	1	3
86	R:R:C148	R:R:C227	7.28	No	No	0	9	9
87	R:R:I152	R:R:W151	3.52	No	Yes	1	5	5
88	R:R:D155	R:R:W151	3.35	Yes	Yes	1	8	5
89	R:R:I152	R:R:I210	4.42	No	Yes	1	5	6
90	R:R:I152	R:R:L229	2.85	No	Yes	1	5	4
91	R:R:L154	R:R:Y153	3.52	No	Yes	0	5	6
92	R:R:L157	R:R:Y153	4.69	Yes	Yes	8	6	6
93	R:R:S207	R:R:Y153	7.63	No	Yes	8	7	6
94	R:R:P211	R:R:Y153	13.91	No	Yes	0	5	6
95	R:R:F158	R:R:L154	6.09	Yes	No	0	7	5
96	R:R:D155	R:R:Y370	9.2	Yes	Yes	1	8	7
97	R:R:I210	R:R:V156	4.61	Yes	No	0	6	6
98	R:R:F158	R:R:L157	4.87	Yes	Yes	0	7	6
99	R:R:L157	R:R:V204	2.98	Yes	No	0	6	4
100	R:R:L157	R:R:S207	6.01	Yes	No	8	6	7
101	R:R:S203	R:R:T160	3.2	No	No	0	8	7
102	R:R:I206	R:R:T160	6.08	No	No	0	6	7
103	R:R:A161	R:R:W200	5.19	No	Yes	2	8	9
104	R:R:A161	R:R:S203	3.42	No	No	2	8	8
105	R:R:I163	R:R:P246	3.39	No	No	0	8	9
106	R:R:I202	R:R:M164	2.92	No	No	0	5	6
107	R:R:M164	R:R:P246	3.35	No	No	0	6	9
108	R:R:H165	R:R:V199	9.69	Yes	No	2	8	6
109	R:R:H165	R:R:W200	8.46	Yes	Yes	2	8	9
110	R:R:L166	R:R:N376	8.24	No	No	3	8	9
111	R:R:L166	R:R:Y380	7.03	No	Yes	3	8	9
112	R:R:C167	R:R:I249	3.27	No	No	0	6	6
113	R:R:I169	R:R:R173	6.26	No	No	0	9	9
114	R:R:M250	R:R:S170	3.07	No	No	0	8	9
115	R:R:S170	R:R:T253	4.8	No	No	0	9	5
116	R:R:I249	R:R:L171	2.85	No	No	0	6	6
117	R:R:L171	R:R:T253	2.95	No	No	0	6	5
118	R:R:D172	R:R:H183	6.3	No	Yes	4	9	7
119	R:R:D172	R:R:K191	8.3	No	No	4	9	6
120	R:R:D172	R:R:K195	4.15	No	No	0	9	6
121	R:R:R173	R:R:V328	3.92	No	Yes	3	9	8
122	R:R:R173	R:R:Y380	7.2	No	Yes	3	9	9
123	R:R:Q178	R:R:Y174	11.27	No	Yes	0	6	8
124	R:R:L256	R:R:Y174	9.38	No	Yes	0	5	8
125	R:R:T257	R:R:Y174	4.99	No	Yes	0	9	8
126	R:R:A176	R:R:H183	8.78	No	Yes	0	8	7
127	R:R:I177	R:R:T257	4.56	No	No	0	9	9
128	R:R:I177	R:R:L261	5.71	No	Yes	0	9	8
129	R:R:Q178	R:R:S260	5.78	No	No	0	6	6
130	R:R:H182	R:R:N179	3.83	No	No	0	5	6
131	R:R:H183	R:R:N187	11.48	Yes	No	4	7	6
132	R:R:H183	R:R:K191	3.93	Yes	No	4	7	6
133	R:R:K191	R:R:N187	4.2	No	No	4	6	6
134	R:R:S188	R:R:T190	6.4	No	No	0	7	5
135	R:R:F193	R:R:R189	4.28	No	No	0	4	4
136	R:R:S203	R:R:W200	4.94	No	Yes	2	8	9
137	R:R:G205	R:R:M208	3.49	No	No	0	4	4
138	R:R:I206	R:R:V241	3.07	No	No	0	6	4
139	R:R:M208	R:R:P209	3.35	No	No	0	4	7
140	R:R:F213	R:R:P209	2.89	No	No	0	4	7
141	R:R:F234	R:R:P209	5.78	Yes	No	0	7	7
142	R:R:I210	R:R:P211	3.39	Yes	No	0	6	5
143	R:R:I210	R:R:L229	4.28	Yes	Yes	1	6	4
144	R:R:F234	R:R:I210	5.02	Yes	Yes	1	7	6
145	R:R:F213	R:R:V212	9.18	No	No	0	4	5
146	R:R:D217	R:R:Q216	7.83	No	No	0	4	6
147	R:R:D217	R:R:K220	11.06	No	No	0	4	3
148	R:R:C227	R:R:F222	9.78	No	Yes	0	9	2
149	R:R:K223	R:R:S226	3.06	No	No	0	3	4
150	R:R:F234	R:R:L229	4.87	Yes	Yes	1	7	4
151	R:R:L229	R:R:V235	2.98	Yes	No	0	4	6
152	R:R:D231	R:R:F234	5.97	No	Yes	0	5	7
153	R:R:D232	R:R:N233	4.04	No	No	0	4	3
154	R:R:N343	R:R:V235	5.91	No	No	0	7	6
155	R:R:L236	R:R:V347	4.47	No	No	0	6	5
156	R:R:F340	R:R:S239	7.93	Yes	No	0	7	6
157	R:R:I344	R:R:S239	4.64	No	No	0	5	6
158	R:R:F240	R:R:F244	3.22	No	No	0	4	5
159	R:R:F243	R:R:F332	5.36	No	No	1	8	9
160	R:R:F243	R:R:W336	3.01	No	Yes	1	8	8
161	R:R:F243	R:R:F340	28.94	No	Yes	1	8	7
162	R:R:F244	R:R:I344	3.77	No	No	0	5	5
163	R:R:I245	R:R:P246	5.08	No	No	0	5	9
164	R:R:I245	R:R:I249	2.94	No	No	0	5	6
165	R:R:I252	R:R:T248	3.04	No	No	0	5	3
166	R:R:F332	R:R:M250	9.95	No	No	0	9	8
167	R:R:I258	R:R:Y254	9.67	No	No	0	5	9
168	R:R:G326	R:R:Y254	4.35	No	No	0	6	9
169	R:R:F329	R:R:Y254	18.57	Yes	No	0	8	9
170	R:R:F255	R:R:K259	6.2	No	No	0	1	4
171	R:R:L325	R:R:T257	2.95	No	No	0	8	9
172	R:R:C322	R:R:I258	3.27	No	No	0	7	5
173	R:R:C322	R:R:L261	4.76	No	Yes	0	7	8
174	R:R:E264	R:R:E318	19.03	No	No	0	7	8
175	R:R:E318	R:R:I315	10.93	No	No	0	8	5
176	R:R:K320	R:R:K323	2.87	No	No	0	8	7
177	R:R:F383	R:R:V324	13.11	No	No	0	7	8
178	R:R:V328	R:R:Y380	5.05	Yes	Yes	3	8	9
179	R:R:F329	R:R:F330	7.5	Yes	No	0	8	5
180	R:R:F329	R:R:V333	5.24	Yes	No	0	8	6
181	R:R:L331	R:R:V375	2.98	No	No	0	6	6
182	R:R:F332	R:R:W336	7.02	No	Yes	1	9	8
183	R:R:L371	R:R:M335	5.65	No	No	0	4	8
184	R:R:M335	R:R:S372	6.13	No	No	0	8	9
185	R:R:F339	R:R:W336	3.01	Yes	Yes	1	7	8
186	R:R:F340	R:R:W336	4.01	Yes	Yes	1	7	8
187	R:R:G369	R:R:W336	4.22	No	Yes	0	7	8
188	R:R:S372	R:R:W336	4.94	No	Yes	0	9	8
189	R:R:F365	R:R:P338	8.67	Yes	No	0	5	9
190	R:R:F339	R:R:F340	11.79	Yes	Yes	1	7	7
191	R:R:F339	R:R:L362	3.65	Yes	No	0	7	3
192	R:R:F339	R:R:V366	6.55	Yes	No	0	7	6
193	R:R:L362	R:R:T342	2.95	No	No	0	3	5
194	R:R:F365	R:R:T342	5.19	Yes	No	0	5	5
195	R:R:W367	R:R:Y370	7.72	Yes	Yes	0	6	7
196	R:R:N376	R:R:S372	5.96	No	No	0	9	9
197	R:R:V375	R:R:V379	3.21	No	No	0	6	8
198	R:R:N376	R:R:Y380	5.81	No	Yes	3	9	9
199	R:R:T381	R:R:Y387	16.23	No	Yes	0	7	8
200	R:R:F391	R:R:L382	3.65	No	No	0	6	5
201	R:R:N384	R:R:T386	5.85	No	No	0	9	6
202	R:R:N384	R:R:Y387	6.98	No	Yes	0	9	8
203	R:R:K385	R:R:R388	3.71	No	No	0	5	9
204	R:R:K385	R:R:S389	3.06	No	No	0	5	4
205	R:R:R393	R:R:Y394	3.09	No	Yes	0	4	4
206	R:R:A98	R:R:F391	2.77	No	No	0	7	6
207	R:R:L126	R:R:L154	2.77	No	No	0	5	5
208	R:R:H183	R:R:V175	2.77	Yes	No	0	7	5
209	R:R:E102	R:R:K103	2.7	No	No	0	6	6
210	R:R:D231	R:R:N233	2.69	No	No	0	5	3
211	R:R:A98	R:R:Y387	2.67	No	Yes	0	7	8
212	R:R:A390	R:R:Y394	2.67	No	Yes	0	7	4
213	R:R:E318	R:R:L261	2.65	No	Yes	0	8	8
214	R:R:F222	R:R:S145	2.64	Yes	No	0	2	3
215	R:R:N179	R:R:Q178	2.64	No	No	0	6	6
216	R:R:F186	R:R:S188	2.64	No	No	0	4	7
217	R:R:F222	R:R:V221	2.62	Yes	No	0	2	3
218	R:R:F329	R:R:V251	2.62	Yes	No	0	8	5
219	R:R:A119	R:R:W200	2.59	No	Yes	0	8	9
220	R:R:T253	R:R:Y174	2.5	No	Yes	0	5	8
221	R:R:F112	R:R:K195	2.48	Yes	No	0	8	6
222	R:R:F365	R:R:L361	2.44	Yes	No	0	5	4
223	R:R:E102	R:R:R393	2.33	No	No	0	6	4
224	R:R:H182	R:R:R185	2.26	No	No	0	5	4
225	R:R:A90	R:R:G91	1.95	No	No	0	4	8
226	R:R:A149	R:R:G214	1.95	No	No	0	6	7
227	R:R:C337	R:R:P338	1.88	No	No	0	6	9
228	R:R:G214	R:R:V221	1.84	No	No	0	7	3
229	R:R:G238	R:R:V241	1.84	No	No	0	6	4
230	R:R:A108	R:R:A192	1.79	No	No	0	5	7
231	R:R:G238	R:R:I237	1.76	No	No	0	6	4
232	R:R:C349	R:R:I348	1.64	No	No	0	3	4
233	R:R:N179	R:R:P180	1.63	No	No	0	6	8
234	R:R:S389	R:R:S392	1.63	No	No	0	4	3
235	R:R:C349	R:R:M345	1.62	No	No	0	3	4
236	R:R:A346	R:R:I358	1.62	No	No	0	4	4
237	R:R:A82	R:R:M132	1.61	No	No	0	3	6
238	R:R:V235	R:R:V347	1.6	No	No	0	6	5
239	R:R:V324	R:R:V328	1.6	No	Yes	0	8	8
240	R:R:V328	R:R:V379	1.6	Yes	No	0	8	8
241	R:R:A374	R:R:L87	1.58	No	No	0	6	4
242	R:R:A321	R:R:L261	1.58	No	Yes	0	8	8
243	R:R:I368	R:R:V364	1.54	No	No	0	7	4
244	R:R:K220	R:R:S219	1.53	No	No	0	3	3
245	R:R:C322	R:R:Q262	1.53	No	No	0	7	6
246	R:R:I197	R:R:T201	1.52	No	No	0	2	4
247	R:R:I358	R:R:T342	1.52	No	No	0	4	5
248	R:R:L147	R:R:V150	1.49	No	No	0	5	4
249	R:R:L247	R:R:V333	1.49	No	No	0	6	6
250	R:R:I118	R:R:I96	1.47	No	No	0	6	6
251	R:R:D218	R:R:S145	1.47	No	No	0	3	3
252	R:R:G138	R:R:Y139	1.45	No	No	0	5	3
253	R:R:I348	R:R:L236	1.43	No	No	0	4	6
254	R:R:I252	R:R:L256	1.43	No	No	0	5	5
255	R:R:K146	R:R:L215	1.41	No	No	0	1	5
256	R:R:L133	R:R:L143	1.38	No	Yes	0	4	5
257	R:R:L228	R:R:L362	1.38	No	No	0	4	3
258	R:R:L378	R:R:L382	1.38	No	No	0	6	5
259	R:R:I315	R:R:Q319	1.37	No	No	0	5	5
260	R:R:E224	R:R:K223	1.35	No	No	0	2	3
261	R:R:F365	R:R:V364	1.31	Yes	No	0	5	4
262	R:R:D356	R:R:E355	1.3	No	No	0	2	3
263	R:R:V99	R:R:Y111	1.26	No	No	0	7	4
264	R:R:F125	R:R:M121	1.24	No	Yes	0	4	7
265	R:R:L382	R:R:R388	1.21	No	No	0	5	9
266	R:R:R189	R:R:Y111	1.03	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	5.45571	7	1	0
2	R:R:T81	7.6575	4	5	6
3	R:R:T88	3.9225	4	0	7
4	R:R:N92	4.4225	4	6	9
5	R:R:F112	5.34167	6	2	8
6	R:R:D120	4.328	5	6	9
7	R:R:M121	3.55	4	0	7
8	R:R:V127	5.73	4	1	8
9	R:R:M128	5.288	5	0	8
10	R:R:W141	9.446	5	0	7
11	R:R:L143	4.91667	6	7	5
12	R:R:W151	7.114	5	1	5
13	R:R:Y153	7.4375	4	8	6
14	R:R:D155	6.445	4	1	8
15	R:R:L157	4.6375	4	8	6
16	R:R:F158	6.6975	4	0	7
17	R:R:H165	8.86	5	2	8
18	R:R:Y174	7.035	4	0	8
19	R:R:H183	6.652	5	4	7
20	R:R:W200	4.978	5	2	9
21	R:R:I210	4.344	5	1	6
22	R:R:F222	5.0125	4	0	2
23	R:R:L229	3.752	5	1	4
24	R:R:F234	5.41	4	1	7
25	R:R:L261	3.675	4	0	8
26	R:R:V328	3.0425	4	3	8
27	R:R:F329	8.4825	4	0	8
28	R:R:W336	4.36833	6	1	8
29	R:R:F339	6.33	5	1	7
30	R:R:F340	11.466	5	1	7
31	R:R:F365	4.4025	4	0	5
32	R:R:W367	8.9	4	0	6
33	R:R:Y370	7.8725	4	1	7
34	R:R:Y380	6.2725	4	3	9
35	R:R:Y387	8.05833	6	0	8
36	R:R:Y394	5	4	0	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D155	86.795	5.93	Yes	Yes	1	0	8
2	R:R:D155	R:R:Y370	58.2086	9.2	Yes	Yes	1	8	7
3	R:R:W367	R:R:Y370	16.9511	7.72	Yes	Yes	0	6	7
4	R:R:M128	R:R:Y370	62.5707	10.78	Yes	Yes	0	8	7
5	R:R:M128	R:R:T88	69.1595	3.01	Yes	Yes	0	8	7
6	R:R:M128	R:R:V84	14.3685	3.04	Yes	No	0	8	7
7	R:R:L371	R:R:V84	13.5654	2.98	No	No	0	4	7
8	L:L:?1	R:R:F339	42.5488	6.65	Yes	Yes	1	0	7
9	R:R:F339	R:R:W336	38.1822	3.01	Yes	Yes	1	7	8
10	R:R:S372	R:R:W336	31.5523	4.94	No	Yes	0	9	8
11	R:R:M335	R:R:S372	13.5517	6.13	No	No	0	8	9
12	R:R:L371	R:R:M335	13.2278	5.65	No	No	0	4	8
13	L:L:?1	R:R:F340	64.5054	4.66	Yes	Yes	1	0	7
14	R:R:F340	R:R:W336	35.2482	4.01	Yes	Yes	1	7	8
15	R:R:N92	R:R:T88	71.8653	2.92	Yes	Yes	0	9	7
16	R:R:D155	R:R:V127	13.1091	7.3	Yes	Yes	1	8	8
17	R:R:L123	R:R:V127	37.8673	4.47	No	Yes	0	7	8
18	R:R:L123	R:R:S373	37.63	3	No	No	0	7	9
19	R:R:M121	R:R:N92	82.9303	4.21	Yes	Yes	0	7	9
20	R:R:D120	R:R:S373	29.2161	4.42	Yes	No	0	9	9
21	R:R:I93	R:R:M121	77.4275	2.92	No	Yes	0	3	7
22	R:R:I93	R:R:M97	75.5749	2.92	No	No	0	3	4
23	R:R:M97	R:R:Y394	73.7041	8.38	No	Yes	0	4	4
24	R:R:R393	R:R:Y394	68.3108	3.09	No	Yes	0	4	4
25	R:R:E102	R:R:R393	66.3762	2.33	No	No	0	6	4
26	R:R:E102	R:R:L105	60.6361	7.95	No	No	0	6	8
27	R:R:L105	R:R:Y387	54.896	9.38	No	Yes	0	8	8
28	R:R:A98	R:R:Y387	21.5277	2.67	No	Yes	0	7	8
29	R:R:A98	R:R:F391	19.4242	2.77	No	No	0	7	6
30	R:R:V99	R:R:Y387	18.7124	3.79	No	Yes	0	7	8
31	R:R:D120	R:R:L116	25.9308	4.07	Yes	No	0	9	9
32	R:R:H165	R:R:L116	24.7399	9	Yes	No	0	8	9
33	R:R:F112	R:R:H165	16.6408	10.18	Yes	Yes	2	8	8
34	R:R:N376	R:R:S372	20.4052	5.96	No	No	0	9	9
35	R:R:N376	R:R:Y380	17.777	5.81	No	Yes	3	9	9
36	R:R:R173	R:R:Y380	11.179	7.2	No	Yes	3	9	9
37	R:R:I169	R:R:R173	12.9494	6.26	No	No	0	9	9
38	R:R:F112	R:R:I169	13.1867	6.28	Yes	No	0	8	9
39	R:R:H165	R:R:W200	12.2331	8.46	Yes	Yes	2	8	9
40	R:R:F158	R:R:L123	12.8627	6.09	Yes	No	0	7	7
41	R:R:D155	R:R:W151	34.8923	3.35	Yes	Yes	1	8	5
42	R:R:V130	R:R:W151	16.869	11.03	No	Yes	0	4	5
43	R:R:L143	R:R:V130	14.9434	2.98	Yes	No	0	5	4
44	R:R:W141	R:R:W151	48.1201	10.31	Yes	Yes	0	7	5
45	R:R:L143	R:R:W141	15.4271	11.39	Yes	Yes	0	5	7
46	R:R:F222	R:R:W141	19.5747	5.01	Yes	Yes	0	2	7
47	R:R:I210	R:R:P211	12.0734	3.39	Yes	No	0	6	5
48	R:R:P211	R:R:Y153	11.0604	13.91	No	Yes	0	5	6
49	L:L:?1	R:R:L229	28.7963	3.78	Yes	Yes	1	0	4
50	R:R:F332	R:R:W336	74.3749	7.02	No	Yes	1	9	8
51	R:R:F332	R:R:M250	100	9.95	No	No	0	9	8
52	R:R:M250	R:R:S170	97.6364	3.07	No	No	0	8	9
53	R:R:S170	R:R:T253	95.2637	4.8	No	No	0	9	5
54	R:R:L171	R:R:T253	21.4957	2.95	No	No	0	6	5
55	R:R:I249	R:R:L171	18.8401	2.85	No	No	0	6	6
56	R:R:I245	R:R:I249	13.5016	2.94	No	No	0	5	6
57	R:R:I245	R:R:P246	10.8186	5.08	No	No	0	5	9
58	R:R:F243	R:R:F340	28.5362	28.94	No	Yes	1	8	7
59	R:R:F243	R:R:F332	27.975	5.36	No	No	1	8	9
60	R:R:F112	R:R:K195	11.033	2.48	Yes	No	0	8	6
61	R:R:T253	R:R:Y174	73.4988	2.5	No	Yes	0	5	8
62	R:R:Q178	R:R:Y174	16.1754	11.27	No	Yes	0	6	8
63	R:R:T257	R:R:Y174	48.4486	4.99	No	Yes	0	9	8
64	R:R:I177	R:R:T257	43.726	4.56	No	No	0	9	9
65	R:R:I177	R:R:L261	41.1389	5.71	No	Yes	0	9	8
66	R:R:N179	R:R:Q178	10.8186	2.64	No	No	0	6	6
67	R:R:F234	R:R:L229	14.5556	4.87	Yes	Yes	1	7	4
68	R:R:L229	R:R:V235	11.6855	2.98	Yes	No	0	4	6
69	R:R:C322	R:R:L261	26.3597	4.76	No	Yes	0	7	8
70	R:R:C322	R:R:I258	21.0622	3.27	No	No	0	7	5
71	R:R:I258	R:R:Y254	18.4112	9.67	No	No	0	5	9
72	R:R:F329	R:R:Y254	13.4833	18.57	Yes	No	0	8	9
73	R:R:E318	R:R:L261	10.3851	2.65	No	Yes	0	8	8
74	R:R:F339	R:R:L362	12.1692	3.65	Yes	No	0	7	3
75	R:R:L362	R:R:T342	10.2984	2.95	No	No	0	3	5
76	R:R:F391	R:R:L382	13.0453	3.65	No	No	0	6	5
77	R:R:I152	R:R:W151	10.3714	3.52	No	Yes	1	5	5
78	R:R:V127	R:R:W151	33.0033	7.36	Yes	Yes	1	8	5
79	R:R:V127	R:R:Y370	12.1373	3.79	Yes	Yes	1	8	7
80	R:R:S373	R:R:T88	13.1867	6.4	No	Yes	0	9	7
81	R:R:D120	R:R:N92	18.9953	4.04	Yes	Yes	6	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D155	5.93	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:V156	7.33	1	Yes	No	0	6	0	1
L:L:?1	R:R:S159	6.56	1	Yes	No	0	7	0	1
L:L:?1	R:R:L229	3.78	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:S242	3.28	1	Yes	No	0	6	0	1
L:L:?1	R:R:F339	6.65	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F340	4.66	1	Yes	Yes	0	7	0	1
R:R:V127	R:R:W151	7.36	1	Yes	Yes	8	5	2	2
R:R:D155	R:R:V127	7.3	1	Yes	Yes	8	8	1	2
R:R:V127	R:R:Y370	3.79	1	Yes	Yes	8	7	2	2
R:R:I152	R:R:W151	3.52	1	No	Yes	5	5	2	2
R:R:D155	R:R:W151	3.35	1	Yes	Yes	8	5	1	2
R:R:I152	R:R:I210	4.42	1	No	Yes	5	6	2	2
R:R:I152	R:R:L229	2.85	1	No	Yes	5	4	2	1
R:R:D155	R:R:Y370	9.2	1	Yes	Yes	8	7	1	2
R:R:I210	R:R:V156	4.61	1	Yes	No	6	6	2	1
R:R:I210	R:R:L229	4.28	1	Yes	Yes	6	4	2	1
R:R:F234	R:R:I210	5.02	1	Yes	Yes	7	6	2	2
R:R:F234	R:R:L229	4.87	1	Yes	Yes	7	4	2	1
R:R:L229	R:R:V235	2.98	1	Yes	No	4	6	1	2
R:R:F340	R:R:S239	7.93	1	Yes	No	7	6	1	2
R:R:F243	R:R:W336	3.01	1	No	Yes	8	8	2	2
R:R:F243	R:R:F340	28.94	1	No	Yes	8	7	2	1
R:R:F339	R:R:W336	3.01	1	Yes	Yes	7	8	1	2
R:R:F340	R:R:W336	4.01	1	Yes	Yes	7	8	1	2
R:R:F339	R:R:F340	11.79	1	Yes	Yes	7	7	1	1
R:R:F339	R:R:L362	3.65	1	Yes	No	7	3	1	2
R:R:F339	R:R:V366	6.55	1	Yes	No	7	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9AS6_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	245
Number of Links	266
Number of Hubs	36
Number of Links mediated by Hubs	136
Number of Communities	8
Number of Nodes involved in Communities	42
Number of Links involved in Communities	54

Path Summary
Number Of Nodes in MetaPath	82
Number Of Links MetaPath	81
Number of Shortest Paths	51675
Length Of Smallest Path	3
Average Path Length	14.9987
Length of Longest Path	37
Minimum Path Strength	1.295
Average Path Strength	5.60966
Maximum Path Strength	20.365
Minimum Path Correlation	0.7
Average Path Correlation	0.915698
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	38.224
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.3348
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1A
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1A
Name	6-AMINO HEXANOIC ACID
Synonyms
Identifier
Formula	C33 H40 N4 O6
Molecular Weight	588.694
SMILES
PubChem	5327090
Formal Charge	0
Total Atoms	83
Total Chiral Atoms	4
Total Bonds	86
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P28223
Sequence	>9AS6_nogp_Chain_R L L T A V V I I L T I A G N I L V I M A V S L E K K L Q N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G Y R W P L P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N P I H H S R F N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D S K V F K E G S C L L A D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T Y R S A F S R Y I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6WGT	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WH4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Methiothepin	-	-	3.4	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WHA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.36	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	6WHA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DB13948	-		3.36	2020-09-23	doi.org/10.1016/j.cell.2020.08.024
	8ZMG	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Pimavanserin	-	-	3.4	2024-08-28	doi.org/10.1021/acs.jmedchem.4c01244
	7RAN	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.45	2022-07-06	doi.org/10.1038/s41586-022-05258-z
	7RAN (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 164575847	-		3.45	2022-07-06	doi.org/10.1038/s41586-022-05258-z
	7VOD	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Cariprazine	-	-	3.3	2021-12-22	doi.org/10.1038/s41593-021-00971-w
	7VOE	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Aripiprazole	-	-	2.9	2021-12-22	doi.org/10.1038/s41593-021-00971-w
	6A93	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Risperidone	-	-	3	2019-02-13	doi.org/10.1038/s41594-018-0180-z
	6A94	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Zotepine	-	-	2.9	2019-02-13	doi.org/10.1038/s41594-018-0180-z
	7WC4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	-	3.2	2022-01-26	doi.org/10.1126/science.abl8615
	7WC5	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	-	3.2	2022-01-26	doi.org/10.1126/science.abl8615
	7WC6	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	2.6	2022-01-26	doi.org/10.1126/science.abl8615
	7WC7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	-	2.6	2022-01-26	doi.org/10.1126/science.abl8615
	7WC8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lumateperone	-	-	2.45	2022-01-26	doi.org/10.1126/science.abl8615
	7WC9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 162421364	-	-	2.5	2022-01-26	doi.org/10.1126/science.abl8615
	8UWL	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-	chim(NtGi2-Gs-CtGq)/β1/γ2	2.8	2024-05-29	doi.org/10.1126/science.adn6354
	8UWL (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Lisuride	-		2.8	2024-05-29	doi.org/10.1126/science.adn6354
	8V6U	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 171392456	-	chim(NtGi2-Gs-CtGq)/β1/γ2	3	2024-05-29	doi.org/10.1126/science.adn6354
	8V6U (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	PubChem 171392456	-		3	2024-05-29	doi.org/10.1126/science.adn6354
	8JT8	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	(R)-IHCH-7179	-	-	2.7	2024-02-28	doi.org/10.1016/j.cell.2024.02.034
	9ARX	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	-	3.24	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARY	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.27	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARY (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Serotonin	-		3.27	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ARZ	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-	-	3.37	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS0	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS0 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	2-bromo-LSD	-		3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS1	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-	-	3.38	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS2	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.21	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS2 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	DMT	-		3.21	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS3	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	-	3.18	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS4	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.06	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS4 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	LSD	-		3.06	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS5	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-	-	3.34	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS6	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.07	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS6 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Mescaline	-		3.07	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS7	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	Psilocin	-	-	2.72	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9AS9	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-	-	3.47	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ASA	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.12	2025-04-02	doi.org/10.1038/s41467-025-57956-7
	9ASA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_2A	Homo sapiens	RS130-180	-		3.12	2025-04-02	doi.org/10.1038/s41467-025-57956-7

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