Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Q12 5.995402
2A:A:Q19 9.6575434
3A:A:Y37 7.9375404
4A:A:L45 7.6925448
5A:A:K53 7.896549
6A:A:F219 6.706508
7A:A:M221 5.7575408
8A:A:F222 10.8585127
9A:A:Q227 4.8575419
10A:A:E230 5.695489
11A:A:K233 8.37489
12A:A:W234 7.705419
13A:A:F238 9.395129
14A:A:V247 4.796547
15A:A:Y253 8.394578
16A:A:R265 10.4125409
17A:A:F273 6.65714729
18A:A:W277 10.4017626
19A:A:W281 12.9567615
20A:A:L282 6.6575409
21A:A:I288 5.956549
22A:A:F290 6.766549
23A:A:N292 5.755449
24A:A:K293 5.6925409
25A:A:Q294 7.225426
26A:A:F312 3.704578
27A:A:F315 12.7525476
28A:A:Y318 6.665406
29A:A:D323 6.415404
30A:A:P328 4.1925401
31A:A:K338 7.9125425
32A:A:Y339 9.1125423
33A:A:F340 8.878577
34A:A:R342 7.144524
35A:A:E344 6.9375475
36A:A:F345 9.87408
37A:A:Y358 9.314204
38A:A:C359 5.41425
39A:A:Y360 9.4865208
40A:A:P361 6.405425
41A:A:F363 10.58425
42A:A:I375 4.8925449
43A:A:F376 6.68754148
44A:A:R385 10.944205
45B:B:L51 8.9025439
46B:B:H54 8.714539
47B:B:K57 13.49419
48B:B:Y59 8.2425418
49B:B:W63 7.158507
50B:B:V71 4.976508
51B:B:D76 7.75409
52B:B:I80 7.948538
53B:B:W82 11.908539
54B:B:Y85 13.534134
55B:B:N88 9.5125437
56B:B:K89 7.125639
57B:B:I93 4.28407
58B:B:L95 5.595408
59B:B:W99 10.276129
60B:B:Y105 5.352506
61B:B:Y111 6.2225404
62B:B:Y124 6506
63B:B:H142 9.366599
64B:B:Y145 5.83167618
65B:B:F151 5.10333609
66B:B:T159 5.948599
67B:B:D163 8.23599
68B:B:W169 10.1367698
69B:B:F180 8.358567
70B:B:H183 10.1267669
71B:B:F199 7.388569
72B:B:C204 7.3425487
73B:B:D205 8.1469
74B:B:K209 10.562566
75B:B:L210 8.33455
76B:B:W211 8.60571768
77B:B:Q220 7.85457
78B:B:H225 11.16509
79B:B:D228 9.89489
80B:B:I232 5.8625458
81B:B:F235 8.408336106
82B:B:P236 7.78254107
83B:B:N237 10.08254105
84B:B:F241 9.276556
85B:B:T249 4.7925456
86B:B:R251 9.85167658
87B:B:F253 8.914556
88B:B:M262 5.95754214
89B:B:Y264 5.267215
90B:B:H266 8.9154154
91B:B:R283 6.9685229
92B:B:L285 5.5125406
93B:B:L286 4.395407
94B:B:Y289 6.67507
95B:B:D290 9.89416
96B:B:D298 8.7954229
97B:B:H311 11.34119
98B:B:D312 7.6625405
99B:B:R314 16.406518
100B:B:W332 10.8686719
101B:B:K337 10.89754116
102B:B:W339 12.01254119
103G:G:R27 5.3508
104G:G:Y40 10.744106
105G:G:H44 5.885406
106G:G:D48 5.5725409
107G:G:N59 6.6365139
108G:G:F61 8.576676138
109R:R:V32 4.09754254
110R:R:F53 6.884267
111R:R:F67 6.1508
112R:R:F105 4.181437275
113R:R:W118 5.05404
114R:R:D126 5.06254169
115R:R:Y128 9.774288
116R:R:I131 5.004509
117R:R:Y137 7.8454167
118R:R:K170 8.64254184
119R:R:Y173 7.825181
120R:R:H174 5.935404
121R:R:F178 4.6125274
122R:R:W185 8.3425407
123R:R:Y200 6.593336175
124R:R:Y211 6.1175409
125R:R:F232 7.315404
126R:R:F261 9.5175409
127R:R:W265 7.71254178
128R:R:Y268 7.4275406
129R:R:F272 7.5925405
130R:R:E275 5.89402
131R:R:F287 11.2154245
132R:R:W291 8.138504
133R:R:S297 7.27409
134R:R:Y304 8.99254299
135R:R:F311 8.955409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:I80 B:B:K78 51.01425.82YesNo088
2B:B:D76 B:B:L55 49.414513.57YesNo096
3B:B:D76 B:B:K78 52.38886.91YesNo098
4A:A:Y37 B:B:L55 49.7368.21YesNo046
5B:B:A56 B:B:D76 49.32884.63NoYes079
6A:A:Y37 B:B:A56 49.45054YesNo047
7A:A:R42 A:A:Y37 99.770814.4NoYes094
8A:A:F222 A:A:R42 99.876.41YesNo079
9A:A:F290 A:A:V247 92.44713.93YesYes497
10A:A:N292 A:A:V247 94.28614.43YesYes497
11A:A:K293 A:A:N292 95.28218.39YesYes099
12A:A:D249 A:A:K293 95.86755.53NoYes089
13A:A:D249 A:A:D252 95.98683.99NoNo088
14A:A:D252 A:A:K300 96.46845.53NoNo089
15A:A:K300 A:A:Y253 96.521214.33NoYes798
16A:A:I308 A:A:Y253 98.302512.09NoYes778
17A:A:F315 A:A:I308 98.35248.79YesNo767
18A:A:F315 A:A:F340 97.300217.15YesYes767
19A:A:E344 A:A:F340 96.63748.16YesYes757
20A:A:E344 A:A:L270 97.43527.95YesNo056
21A:A:F345 A:A:L270 48.876212.18YesNo086
22A:A:F273 A:A:F345 48.93648.57YesYes098
23A:A:F246 A:A:F273 99.569910.72NoYes299
24A:A:F246 A:A:L272 1008.53NoNo098
25A:A:L272 A:A:R231 90.921110.93NoNo089
26A:A:R231 A:A:W234 90.88258NoYes099
27A:A:V224 A:A:W234 78.223413.48NoYes099
28A:A:F238 A:A:V224 77.97673.93YesNo099
29A:A:F222 A:A:F238 77.19645.36YesYes1279
30A:A:I348 A:A:L270 48.6474.28NoNo046
31A:A:F273 A:A:I348 48.66896.28YesNo094
32A:A:F290 A:A:I288 89.54565.02YesYes499
33A:A:F222 B:B:W99 23.463523.05YesYes1279
34B:B:L117 B:B:W99 10.49564.56NoYes099
35A:A:Q227 B:B:L117 10.53975.32YesNo099
36A:A:W234 B:B:Y145 29.97623.86YesYes198
37B:B:Q75 B:B:W99 14.11279.86NoYes099
38A:A:W281 B:B:D290 13.887710.05YesYes156
39A:A:D378 A:A:Y360 89.825817.24NoYes078
40A:A:D378 A:A:I288 90.453211.2NoYes079
41A:A:R385 A:A:Y360 88.973113.38YesYes2058
42A:A:R385 R:R:H221 88.876312.41YesNo057
43A:A:Q384 R:R:H221 44.168812.36NoNo067
44A:A:Q384 R:R:I131 44.04334.12NoYes069
45A:A:Y391 R:R:I131 87.33224.84NoYes049
46A:A:Y391 R:R:R127 87.06177.2NoNo049
47A:A:L388 R:R:H221 44.60185.14NoNo087
48A:A:L388 R:R:I131 44.10014.28NoYes089
49B:B:S147 B:B:Y145 30.31773.82NoYes098
50B:B:S147 B:B:S160 30.1294.89NoNo096
51B:B:S160 B:B:V187 18.72048.08NoNo069
52B:B:H183 B:B:V187 17.33595.54YesNo099
53B:B:H183 B:B:K209 15.152523.58YesYes696
54B:B:K209 B:B:T221 14.466410.51YesNo067
55B:B:T221 G:G:E22 14.2645.64NoNo079
56B:B:D258 G:G:E22 12.02965.2NoNo079
57B:B:C271 B:B:D290 20.67454.67NoYes056
58B:B:C271 B:B:Y289 20.07465.38NoYes057
59B:B:W297 B:B:Y289 17.35934.82NoYes087
60B:B:W297 B:B:Y264 15.24884.82NoYes085
61B:B:S84 B:B:W63 11.14724.94NoYes057
62B:B:T321 B:B:W63 70.895210.92NoYes077
63B:B:G324 B:B:T321 69.18823.64NoNo097
64B:B:G324 G:G:P49 68.6194.06NoNo097
65G:G:D48 G:G:P49 66.91066.44YesNo097
66B:B:S279 G:G:D48 56.06465.89NoYes099
67B:B:L286 B:B:S279 53.2033YesNo079
68B:B:L286 B:B:V327 51.48454.47YesNo076
69B:B:M45 B:B:V327 49.76493.04NoNo046
70B:B:L308 B:B:M45 48.61797.07NoNo074
71B:B:L308 B:B:W339 48.044219.36NoYes079
72B:B:K337 B:B:W339 23.73649.28YesYes1169
73B:B:L70 B:B:W82 85.49166.83NoYes359
74B:B:H54 B:B:W82 43.55584.23YesYes399
75B:B:H54 B:B:S74 44.670812.55YesNo399
76B:B:L190 B:B:S160 11.77954.5NoNo056
77B:B:C148 B:B:L190 11.26946.35NoNo065
78B:B:C148 B:B:R150 11.0644.18NoNo066
79B:B:T329 B:B:W339 23.157710.92NoYes089
80B:B:H311 B:B:T329 20.85056.85YesNo098
81B:B:D333 B:B:H311 39.388112.61NoYes1199
82B:B:D312 B:B:D333 38.233513.31YesNo059
83B:B:H311 B:B:K337 20.85511.79YesYes1196
84B:B:D312 R:R:L58 32.45355.43YesNo055
85R:R:L254 R:R:R127 83.53364.86NoNo089
86R:R:L254 R:R:Y211 79.16254.69NoYes089
87R:R:T258 R:R:Y211 71.43668.74NoYes079
88R:R:L120 R:R:T258 71.15894.42NoNo087
89R:R:F261 R:R:L120 70.03486.09YesNo098
90R:R:F261 R:R:N296 51.039618.12YesNo099
91R:R:K113 R:R:N296 50.75688.39NoNo069
92R:R:I294 R:R:K113 36.29264.36NoNo076
93R:R:F261 R:R:S116 18.48116.61YesNo099
94R:R:D75 R:R:S116 18.19654.42NoNo099
95R:R:D75 R:R:S297 14.564410.31NoYes099
96R:R:I42 R:R:S297 10.80236.19NoYes089
97R:R:F298 R:R:I42 10.20325.02NoNo068
98R:R:K113 R:R:S297 14.57496.12NoYes069
99R:R:L58 R:R:L59 28.9814.15NoNo059
100R:R:H62 R:R:L59 27.82325.14NoNo079
101R:R:H62 R:R:S65 26.66534.18NoNo079
102R:R:F53 R:R:S65 24.34796.61YesNo2679
103R:R:F311 R:R:F53 22.03266.43YesYes097
104R:R:S297 R:R:V78 17.82816.46YesNo098
105R:R:V109 R:R:V78 15.49884.81NoNo068
106R:R:H174 R:R:I294 30.21945.3YesNo047
107R:R:F105 R:R:V109 22.18635.24YesNo056
108R:R:F105 R:R:F178 10.66415.36YesYes2754
109R:R:H174 R:R:Y268 17.14588.71YesYes046
110R:R:W265 R:R:Y268 10.90737.72YesYes086
111R:R:W265 R:R:Y200 10.00046.75YesYes1785
112B:B:L70 B:B:W63 84.972611.39NoYes057
113B:B:I80 B:B:W82 43.580212.92YesYes389
114B:B:D76 B:B:S74 46.09055.89YesNo099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8HIX
Class A
SubFamily Orphan
Type A orphans
SubType GPR21
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.12
Date 2023-03-15
D.O.I. 10.1038/s41467-023-35882-w
Net Summary
Imin 3.82
Number of Linked Nodes 868
Number of Links 983
Number of Hubs 135
Number of Links mediated by Hubs 516
Number of Communities 29
Number of Nodes involved in Communities 178
Number of Links involved in Communities 235
Path Summary
Number Of Nodes in MetaPath 115
Number Of Links MetaPath 114
Number of Shortest Paths 2442553
Length Of Smallest Path 3
Average Path Length 44.7757
Length of Longest Path 86
Minimum Path Strength 1.14
Average Path Strength 7.99607
Maximum Path Strength 23.34
Minimum Path Correlation 0.7
Average Path Correlation 0.986806
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.42857
Average % Of Corr. Nodes 33.0267
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.881
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8HIX_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGADNSGK 
STIVKQMRI LSGGTSGIF ETKFQVDKV NFHMFDVGG QRDERRKWI 
QCFNDVTAI IFVVDSSDY NRLQEALNL FKSIWNNRW LRTISVILF 
LNKQDLLAE KVLAGKSKI EDYFPEFAR YTTPEDATP EPGEDPRVT 
RAKYFIRDE FLRISTASG DGRHYCYPH FTCAVDTEN ARRIFNDCR 
DIIQRMHLR QYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8HIX_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8HIX_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ99679
Sequence
>8HIX_Chain_R
VNFCLLEVL IIVFLTVLI ISGNIIVIF VFHCAPLLN HHTTSYFIQ 
TMAYADLFV GVSCVVPSL SLLHHPLPV EESLTCQIF GFVVSVLKS 
VSMWSLACI SIDRYIAIT KPLTYNTLV TPWRLRLCI FLIWLYSTL 
VFLPSFFHW GKPGYHGDV FQWCAESWH TDSYFTLFI VMMLYAPAA 
LIVCFTYFN IFRICQQHT KDISERQAR FSSMVLFRI TSVFYILWL 
PYIIYFLLE SSTGHSNRF ASFLTTWLA ISNSFCNPV IYALSDSTF 
QRGLKRLSG AMCT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HIXAOrphanA orphansGPR21Homo sapiens--Gs/&β;1/&γ;23.122023-03-1510.1038/s41467-023-35882-w
8HJ0AOrphanA orphansGPR21Homo sapiens--chim(Gs-CtG15)/&β;1/&γ;23.122023-03-1510.1038/s41467-023-35882-w
8HJ1AOrphanA orphansGPR21Homo sapiens--Gs/&β;1/&γ;23.272023-12-2710.1038/s41467-023-35882-w
8HJ2AOrphanA orphansGPR21Homo sapiens--chim(Gs-CtG15)/&β;1/&γ;23.82023-03-1510.1038/s41467-023-35882-w
8HMVAOrphanA orphansGPR21Homo sapiens--Gs/&β;1/&γ;22.912023-03-0110.1002/mco2.205




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8HIX.zip



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