psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E31	R:R:F287	8.16	No	Yes	0	4	5
2	R:R:L89	R:R:V32	2.98	No	No	0	4	4
3	R:R:L90	R:R:V32	2.98	No	No	0	5	4
4	R:R:I34	R:R:L38	2.85	No	No	0	5	7
5	R:R:I35	R:R:W291	12.92	No	Yes	0	6	4
6	R:R:S86	R:R:V36	3.23	No	No	0	7	4
7	R:R:F37	R:R:L41	9.74	No	No	0	4	4
8	R:R:L38	R:R:S295	3	No	No	0	7	6
9	R:R:I43	R:R:T39	3.04	Yes	No	0	6	6
10	R:R:C82	R:R:T39	6.76	No	No	0	7	6
11	R:R:I42	R:R:N46	2.83	No	Yes	0	8	9
12	R:R:G79	R:R:I42	3.53	No	No	0	7	8
13	R:R:I43	R:R:I47	2.94	Yes	No	4	6	5
14	R:R:I43	R:R:L76	2.85	Yes	No	4	6	6
15	R:R:G79	R:R:I43	3.53	No	Yes	0	7	6
16	R:R:G45	R:R:S44	3.71	Yes	No	0	8	4
17	R:R:D75	R:R:N46	6.73	Yes	Yes	0	9	9
18	R:R:L76	R:R:N46	6.87	No	Yes	0	6	9
19	R:R:C301	R:R:N46	3.15	No	Yes	0	9	9
20	R:R:I47	R:R:L76	2.85	No	No	4	5	6
21	R:R:C301	R:R:V49	3.42	No	No	0	9	9
22	R:R:S305	R:R:V49	6.46	No	No	0	7	9
23	R:R:H54	R:R:I50	2.65	No	No	5	3	7
24	R:R:I50	R:R:Y73	6.04	No	No	5	7	6
25	R:R:F311	R:R:V52	14.42	Yes	No	0	9	8
26	R:R:L315	R:R:V52	2.98	No	No	0	6	8
27	R:R:F53	R:R:L59	4.87	No	No	0	7	9
28	R:R:F53	R:R:Q69	5.86	No	No	0	7	6
29	R:R:F311	R:R:F53	3.22	Yes	No	0	9	7
30	R:R:H54	R:R:Y73	4.36	No	No	5	3	6
31	R:R:P57	R:R:R317	5.76	No	No	0	6	4
32	R:R:H61	R:R:L58	9	No	No	0	8	5
33	R:R:N60	R:R:Q69	6.6	No	No	0	5	6
34	R:R:H62	R:R:T63	2.74	No	Yes	1	7	5
35	R:R:H62	R:R:Y137	8.71	No	Yes	1	7	7
36	R:R:D126	R:R:T63	8.67	Yes	Yes	1	9	5
37	R:R:T63	R:R:Y137	4.99	Yes	Yes	1	5	7
38	R:R:T63	R:R:V141	3.17	Yes	Yes	1	5	6
39	R:R:L146	R:R:T63	7.37	Yes	Yes	1	7	5
40	R:R:I68	R:R:T64	3.04	No	No	1	8	8
41	R:R:I123	R:R:T64	4.56	Yes	No	1	9	8
42	R:R:D126	R:R:T64	7.23	Yes	No	1	9	8
43	R:R:L146	R:R:Y66	8.21	Yes	No	0	7	4
44	R:R:C122	R:R:F67	9.78	No	No	0	7	8
45	R:R:F67	R:R:L146	3.65	No	Yes	0	8	7
46	R:R:C149	R:R:F67	5.59	No	No	0	6	8
47	R:R:I123	R:R:I68	2.94	Yes	No	1	9	8
48	R:R:S119	R:R:T70	3.2	No	No	0	8	9
49	R:R:I150	R:R:T70	6.08	No	No	0	8	9
50	R:R:D75	R:R:M71	4.16	Yes	Yes	1	9	9
51	R:R:I123	R:R:M71	2.92	Yes	Yes	1	9	9
52	R:R:M71	R:R:N300	7.01	Yes	Yes	1	9	9
53	R:R:M71	R:R:Y304	4.79	Yes	Yes	1	9	9
54	R:R:A74	R:R:V115	3.39	No	No	0	8	7
55	R:R:D75	R:R:S116	5.89	Yes	No	0	9	9
56	R:R:D75	R:R:S297	8.83	Yes	No	0	9	9
57	R:R:D75	R:R:N300	4.04	Yes	Yes	1	9	9
58	R:R:L112	R:R:V78	4.47	Yes	No	0	6	8
59	R:R:L87	R:R:V83	2.98	No	No	0	5	7
60	R:R:P85	R:R:V84	3.53	No	No	0	3	8
61	R:R:F105	R:R:P85	8.67	No	No	0	5	3
62	R:R:F178	R:R:S88	5.28	No	No	0	4	5
63	R:R:L89	R:R:V177	4.47	No	No	0	4	2
64	R:R:L94	R:R:P95	4.93	No	No	0	4	7
65	R:R:L94	R:R:V96	2.98	No	No	0	4	3
66	R:R:L94	R:R:T101	4.42	No	No	0	4	5
67	R:R:L100	R:R:V96	2.98	No	No	0	1	3
68	R:R:E97	R:R:S99	5.75	No	No	0	5	3
69	R:R:E98	R:R:T101	2.82	No	No	0	7	5
70	R:R:E98	R:R:F178	7	No	No	0	7	4
71	R:R:S99	R:R:W180	8.65	No	Yes	0	3	3
72	R:R:I104	R:R:L100	4.28	No	No	0	4	1
73	R:R:C102	R:R:F178	2.79	No	No	0	9	4
74	R:R:C102	R:R:W180	3.92	No	Yes	0	9	3
75	R:R:C102	R:R:C181	7.28	No	No	0	9	9
76	R:R:Q103	R:R:W185	16.43	No	Yes	0	5	7
77	R:R:F107	R:R:V111	6.55	No	No	0	6	5
78	R:R:F107	R:R:F165	10.72	No	No	0	6	5
79	R:R:L112	R:R:V108	2.98	Yes	No	0	6	4
80	R:R:H174	R:R:V109	5.54	Yes	No	0	4	6
81	R:R:F161	R:R:S110	5.28	Yes	No	0	6	4
82	R:R:H174	R:R:S110	6.97	Yes	No	0	4	4
83	R:R:H174	R:R:K113	9.17	Yes	Yes	3	4	6
84	R:R:K113	R:R:W265	5.8	Yes	Yes	3	6	8
85	R:R:K113	R:R:Y268	3.58	Yes	No	3	6	6
86	R:R:A293	R:R:K113	3.21	No	Yes	0	7	6
87	R:R:S114	R:R:S157	3.26	No	No	0	6	8
88	R:R:F161	R:R:S114	6.61	Yes	No	6	6	6
89	R:R:L199	R:R:S114	3	No	No	6	7	6
90	R:R:V115	R:R:W154	11.03	No	No	0	7	9
91	R:R:S157	R:R:V115	4.85	No	No	0	8	7
92	R:R:M117	R:R:Y200	3.59	No	Yes	0	7	5
93	R:R:A203	R:R:M117	3.22	No	No	0	6	7
94	R:R:F261	R:R:M117	3.73	Yes	No	0	9	7
95	R:R:A118	R:R:I153	3.25	No	No	0	4	6
96	R:R:I153	R:R:S119	3.1	No	No	0	6	8
97	R:R:F261	R:R:L120	9.74	Yes	No	0	9	8
98	R:R:L120	R:R:N300	4.12	No	Yes	0	8	9
99	R:R:L120	R:R:Y304	7.03	No	Yes	0	8	9
100	R:R:C122	R:R:I153	4.91	No	No	0	7	6
101	R:R:I123	R:R:R127	3.76	Yes	No	1	9	9
102	R:R:I123	R:R:Y304	3.63	Yes	Yes	1	9	9
103	R:R:S124	R:R:T210	7.99	No	No	0	8	6
104	R:R:S124	R:R:Y211	5.09	No	Yes	0	8	9
105	R:R:I125	R:R:I129	2.94	No	No	0	6	5
106	R:R:I125	R:R:I206	4.42	No	No	0	6	8
107	R:R:D126	R:R:Y137	8.05	Yes	Yes	1	9	7
108	R:R:D126	R:R:V141	2.92	Yes	Yes	1	9	6
109	R:R:R127	R:R:Y211	7.2	No	Yes	1	9	9
110	R:R:R127	R:R:Y304	4.12	No	Yes	1	9	9
111	R:R:T132	R:R:Y128	8.74	No	Yes	0	6	8
112	R:R:F209	R:R:Y128	6.19	No	Yes	7	4	8
113	R:R:T210	R:R:Y128	7.49	No	Yes	0	6	8
114	R:R:N213	R:R:Y128	8.14	No	Yes	7	5	8
115	R:R:I129	R:R:Y137	3.63	No	Yes	1	5	7
116	R:R:I129	R:R:V141	3.07	No	Yes	1	5	6
117	R:R:A130	R:R:Y137	9.34	No	Yes	0	8	7
118	R:R:I131	R:R:I214	4.42	No	No	0	9	9
119	R:R:I131	R:R:I217	2.94	No	No	0	9	6
120	R:R:K133	R:R:T136	3	Yes	No	0	5	4
121	R:R:K133	R:R:L140	2.82	Yes	No	0	5	4
122	R:R:N138	R:R:Y137	3.49	No	Yes	0	4	7
123	R:R:V141	R:R:Y137	5.05	Yes	Yes	1	6	7
124	R:R:L146	R:R:V141	2.98	Yes	Yes	1	7	6
125	R:R:P143	R:R:T142	3.5	No	No	0	3	8
126	R:R:R145	R:R:T142	10.35	No	No	0	5	8
127	R:R:P143	R:R:R147	4.32	No	No	0	3	1
128	R:R:L148	R:R:W144	3.42	No	No	0	2	4
129	R:R:L148	R:R:L152	5.54	No	No	0	2	3
130	R:R:V160	R:R:Y156	7.57	No	No	0	5	4
131	R:R:M198	R:R:Y156	4.79	No	No	0	6	4
132	R:R:L199	R:R:V160	11.92	No	No	0	7	5
133	R:R:F161	R:R:I195	8.79	Yes	No	0	6	6
134	R:R:F161	R:R:L199	3.65	Yes	No	6	6	7
135	R:R:P163	R:R:W168	10.81	No	No	0	5	5
136	R:R:F191	R:R:P163	5.78	Yes	No	0	5	5
137	R:R:F165	R:R:S164	2.64	No	No	0	5	5
138	R:R:P171	R:R:S164	7.13	No	No	0	3	5
139	R:R:F191	R:R:S164	2.64	Yes	No	0	5	5
140	R:R:K170	R:R:P171	3.35	Yes	No	2	4	3
141	R:R:D176	R:R:K170	6.91	No	Yes	0	4	4
142	R:R:K170	R:R:W185	23.21	Yes	Yes	2	4	7
143	R:R:K170	R:R:T187	7.51	Yes	Yes	2	4	5
144	R:R:P171	R:R:W185	6.76	No	Yes	2	3	7
145	R:R:G172	R:R:H174	3.18	No	Yes	0	1	4
146	R:R:D176	R:R:Y173	6.9	No	Yes	0	4	1
147	R:R:T187	R:R:Y173	6.24	Yes	Yes	2	5	1
148	R:R:Y173	R:R:Y271	5.96	Yes	No	2	1	5
149	R:R:F272	R:R:Y173	8.25	No	Yes	2	5	1
150	R:R:E275	R:R:Y173	13.47	Yes	Yes	2	2	1
151	R:R:H174	R:R:Y268	7.62	Yes	No	3	4	6
152	R:R:H174	R:R:T290	5.48	Yes	No	0	4	5
153	R:R:A182	R:R:D176	3.09	No	No	0	3	4
154	R:R:S184	R:R:W180	22.24	No	Yes	0	3	3
155	R:R:W180	R:R:W185	3.75	Yes	Yes	0	3	7
156	R:R:C181	R:R:W185	7.84	No	Yes	0	9	7
157	R:R:E275	R:R:T187	7.06	Yes	Yes	2	2	5
158	R:R:S276	R:R:T187	4.8	No	Yes	2	3	5
159	R:R:S189	R:R:Y190	7.63	No	No	0	4	7
160	R:R:F191	R:R:I195	11.3	Yes	No	0	5	6
161	R:R:F272	R:R:T192	16.86	No	No	2	5	4
162	R:R:S276	R:R:T192	9.59	No	No	2	3	4
163	R:R:F194	R:R:M198	7.46	No	No	0	6	6
164	R:R:I195	R:R:Y200	4.84	No	Yes	0	6	5
165	R:R:L273	R:R:V196	4.47	No	No	0	6	5
166	R:R:W265	R:R:Y200	3.86	Yes	Yes	0	8	5
167	R:R:I269	R:R:Y200	8.46	No	Yes	0	7	5
168	R:R:A204	R:R:Y262	2.67	No	Yes	0	3	6
169	R:R:V207	R:R:Y262	3.79	No	Yes	0	5	6
170	R:R:F209	R:R:N213	8.46	No	No	7	4	5
171	R:R:L254	R:R:Y211	3.52	No	Yes	0	8	9
172	R:R:I257	R:R:Y211	9.67	No	Yes	1	8	9
173	R:R:T258	R:R:Y211	4.99	No	Yes	1	7	9
174	R:R:F212	R:R:R216	6.41	No	No	0	3	3
175	R:R:F215	R:R:Q219	3.51	No	No	8	6	5
176	R:R:F215	R:R:Y250	7.22	No	Yes	8	6	8
177	R:R:F215	R:R:L254	3.65	No	No	0	6	8
178	R:R:C218	R:R:Y250	6.72	No	Yes	0	8	8
179	R:R:Q219	R:R:Y250	5.64	No	Yes	8	5	8
180	R:R:H221	R:R:Q220	4.95	No	No	0	7	4
181	R:R:E227	R:R:K223	2.7	No	No	0	3	4
182	R:R:F232	R:R:R231	5.34	No	No	0	4	6
183	R:R:F255	R:R:S259	5.28	No	No	0	5	4
184	R:R:I257	R:R:T258	3.04	No	No	1	8	7
185	R:R:L264	R:R:V260	2.98	Yes	Yes	9	8	6
186	R:R:C299	R:R:V260	3.42	No	Yes	9	5	6
187	R:R:I303	R:R:V260	4.61	No	Yes	0	8	6
188	R:R:F261	R:R:Y262	8.25	Yes	Yes	0	9	6
189	R:R:F261	R:R:W265	5.01	Yes	Yes	0	9	8
190	R:R:L266	R:R:Y262	3.52	No	Yes	0	6	6
191	R:R:I263	R:R:L264	2.85	No	Yes	0	5	8
192	R:R:L264	R:R:L292	4.15	Yes	No	0	8	6
193	R:R:L264	R:R:N296	10.98	Yes	No	0	8	9
194	R:R:C299	R:R:L264	3.17	No	Yes	9	5	8
195	R:R:W265	R:R:Y268	2.89	Yes	No	3	8	6
196	R:R:N296	R:R:W265	6.78	No	Yes	0	9	8
197	R:R:P267	R:R:T289	3.5	No	No	0	9	5
198	R:R:E275	R:R:Y271	10.1	Yes	No	2	2	5
199	R:R:S286	R:R:Y271	5.09	No	No	0	4	5
200	R:R:F272	R:R:S276	2.64	No	No	2	5	3
201	R:R:E275	R:R:S281	4.31	Yes	No	0	2	3
202	R:R:G279	R:R:T278	3.64	No	No	0	1	4
203	R:R:F284	R:R:N282	7.25	No	No	0	1	4
204	R:R:A285	R:R:N282	3.13	No	No	0	4	4
205	R:R:F284	R:R:R283	7.48	No	No	0	1	3
206	R:R:F287	R:R:W291	12.03	Yes	Yes	0	5	4
207	R:R:I294	R:R:W291	12.92	No	Yes	0	7	4
208	R:R:L292	R:R:S295	3	No	No	0	6	6
209	R:R:N296	R:R:N300	12.26	No	Yes	0	9	9
210	R:R:L306	R:R:V302	5.96	No	No	0	5	6
211	R:R:I303	R:R:Y304	4.84	No	Yes	0	8	9
212	R:R:F311	R:R:S305	3.96	Yes	No	0	9	7
213	R:R:N308	R:R:V310	4.43	No	No	0	8	6
214	R:R:F287	R:R:V177	2.62	Yes	No	0	5	2
215	R:R:C82	R:R:W291	2.61	No	Yes	0	7	4
216	R:R:H92	R:R:L90	2.57	No	No	0	4	5
217	R:R:F51	R:R:I47	2.51	No	No	0	4	5
218	R:R:T222	R:R:Y250	2.5	No	Yes	0	5	8
219	R:R:F298	R:R:L41	2.44	No	No	0	6	4
220	R:R:F77	R:R:L112	2.44	No	Yes	0	7	6
221	R:R:F287	R:R:L288	2.44	Yes	No	0	5	4
222	R:R:I214	R:R:Y211	2.42	No	Yes	0	9	9
223	R:R:F311	R:R:N308	2.42	Yes	No	0	9	8
224	R:R:H61	R:R:H62	2.39	No	No	0	8	7
225	R:R:L112	R:R:W154	2.28	Yes	No	0	6	9
226	R:R:R145	R:R:W144	2	No	No	0	5	4
227	R:R:C301	R:R:G45	1.96	No	Yes	0	9	8
228	R:R:C181	R:R:G175	1.96	No	No	0	9	3
229	R:R:A56	R:R:P57	1.87	No	No	0	5	6
230	R:R:A201	R:R:P202	1.87	No	No	0	4	9
231	R:R:G106	R:R:S110	1.86	No	No	0	4	4
232	R:R:A121	R:R:A203	1.79	No	No	0	7	6
233	R:R:G45	R:R:I48	1.76	Yes	No	0	8	7
234	R:R:A72	R:R:V49	1.7	No	No	0	9	9
235	R:R:D188	R:R:G169	1.68	No	No	0	3	5
236	R:R:K133	R:R:P134	1.67	Yes	No	0	5	8
237	R:R:L162	R:R:P163	1.64	No	No	0	4	5
238	R:R:L266	R:R:P267	1.64	No	No	0	6	9
239	R:R:A72	R:R:I50	1.62	No	No	0	9	7
240	R:R:S81	R:R:V108	1.62	No	No	0	5	4
241	R:R:S88	R:R:V84	1.62	No	No	0	5	8
242	R:R:S259	R:R:V260	1.62	No	Yes	0	4	6
243	R:R:S309	R:R:V310	1.62	No	No	0	4	6
244	R:R:V32	R:R:V36	1.6	No	No	0	4	4
245	R:R:S226	R:R:T222	1.6	No	No	0	3	5
246	R:R:S277	R:R:T278	1.6	No	No	0	4	4
247	R:R:T39	R:R:V83	1.59	No	No	0	6	7
248	R:R:T158	R:R:V111	1.59	No	No	0	3	5
249	R:R:A56	R:R:L318	1.58	No	No	0	5	6
250	R:R:I269	R:R:V196	1.54	No	No	0	7	5
251	R:R:I303	R:R:V302	1.54	No	No	0	8	6
252	R:R:H92	R:R:P93	1.53	No	No	0	4	4
253	R:R:F298	R:R:G45	1.51	No	Yes	0	6	8
254	R:R:F191	R:R:G169	1.51	Yes	No	0	5	5
255	R:R:A182	R:R:E183	1.51	No	No	0	3	5
256	R:R:K133	R:R:T132	1.5	Yes	No	0	5	6
257	R:R:G314	R:R:R313	1.5	No	No	0	7	4
258	R:R:G314	R:R:R317	1.5	No	No	0	7	4
259	R:R:D188	R:R:S189	1.47	No	No	0	3	4
260	R:R:I270	R:R:L274	1.43	No	No	0	7	4
261	R:R:L193	R:R:M197	1.41	No	No	0	4	4
262	R:R:K316	R:R:L315	1.41	No	No	0	5	6
263	R:R:C55	R:R:F51	1.4	No	No	0	5	4
264	R:R:L152	R:R:L155	1.38	No	No	0	3	3
265	R:R:L193	R:R:L273	1.38	No	No	0	4	6
266	R:R:D224	R:R:K223	1.38	No	No	0	4	4
267	R:R:I225	R:R:Q229	1.37	No	No	0	6	3
268	R:R:H280	R:R:T278	1.37	No	No	0	1	4
269	R:R:C208	R:R:Y262	1.34	No	Yes	0	6	6
270	R:R:E31	R:R:L30	1.33	No	No	0	4	5
271	R:R:R256	R:R:S307	1.32	No	No	0	6	7
272	R:R:R313	R:R:S309	1.32	No	No	0	4	4
273	R:R:R249	R:R:V253	1.31	No	No	0	8	8
274	R:R:R256	R:R:V253	1.31	No	No	0	6	8
275	R:R:F255	R:R:M252	1.24	No	No	0	5	7
276	R:R:F212	R:R:N213	1.21	No	No	0	3	5
277	R:R:E31	R:R:R283	1.16	No	No	0	4	3
278	R:R:F166	R:R:W168	1	No	No	0	3	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I43	3.09	4	4	6
2	R:R:G45	2.235	4	0	8
3	R:R:N46	4.895	4	0	9
4	R:R:T63	5.388	5	1	5
5	R:R:M71	4.72	4	1	9
6	R:R:D75	5.93	5	1	9
7	R:R:L112	3.0425	4	0	6
8	R:R:K113	5.44	4	3	6
9	R:R:I123	3.562	5	1	9
10	R:R:D126	6.7175	4	1	9
11	R:R:Y128	7.64	4	7	8
12	R:R:K133	2.2475	4	0	5
13	R:R:Y137	6.18	7	1	7
14	R:R:V141	3.438	5	1	6
15	R:R:L146	5.5525	4	1	7
16	R:R:F161	6.0825	4	6	6
17	R:R:K170	10.245	4	2	4
18	R:R:Y173	8.164	5	2	1
19	R:R:H174	6.32667	6	3	4
20	R:R:W180	9.64	4	0	3
21	R:R:W185	11.598	5	2	7
22	R:R:T187	6.4025	4	2	5
23	R:R:F191	5.3075	4	0	5
24	R:R:Y200	5.1875	4	0	5
25	R:R:Y211	5.48167	6	1	9
26	R:R:Y250	5.52	4	8	8
27	R:R:V260	3.1575	4	9	6
28	R:R:F261	6.6825	4	0	9
29	R:R:Y262	3.914	5	0	6
30	R:R:L264	4.826	5	9	8
31	R:R:W265	4.868	5	3	8
32	R:R:E275	8.735	4	2	2
33	R:R:F287	6.3125	4	0	5
34	R:R:W291	10.12	4	0	4
35	R:R:N300	6.8575	4	1	9
36	R:R:Y304	4.882	5	1	9
37	R:R:F311	6.005	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F287	R:R:W291	17.7274	12.03	Yes	Yes	0	5	4
2	R:R:C82	R:R:W291	20.8602	2.61	No	Yes	0	7	4
3	R:R:C82	R:R:T39	21.9058	6.76	No	No	0	7	6
4	R:R:I43	R:R:T39	24.9475	3.04	Yes	No	0	6	6
5	R:R:I43	R:R:L76	25.4743	2.85	Yes	No	4	6	6
6	R:R:L76	R:R:N46	29.6527	6.87	No	Yes	0	6	9
7	R:R:D75	R:R:N46	57.3052	6.73	Yes	Yes	0	9	9
8	R:R:D75	R:R:N300	33.5657	4.04	Yes	Yes	1	9	9
9	R:R:N296	R:R:N300	50.2277	12.26	No	Yes	0	9	9
10	R:R:L264	R:R:N296	10.5113	10.98	Yes	No	0	8	9
11	R:R:C301	R:R:N46	31.9577	3.15	No	Yes	0	9	9
12	R:R:C301	R:R:V49	25.1376	3.42	No	No	0	9	9
13	R:R:S305	R:R:V49	20.0285	6.46	No	No	0	7	9
14	R:R:F311	R:R:S305	18.9829	3.96	Yes	No	0	9	7
15	R:R:F311	R:R:N308	10.3331	2.42	Yes	No	0	9	8
16	R:R:D75	R:R:M71	25.803	4.16	Yes	Yes	1	9	9
17	R:R:I123	R:R:M71	36.2707	2.92	Yes	Yes	1	9	9
18	R:R:I123	R:R:T64	66.9809	4.56	Yes	No	1	9	8
19	R:R:D126	R:R:T64	65.559	7.23	Yes	No	1	9	8
20	R:R:D126	R:R:T63	24.1792	8.67	Yes	Yes	1	9	5
21	R:R:D126	R:R:Y137	15.6085	8.05	Yes	Yes	1	9	7
22	R:R:D126	R:R:V141	24.1792	2.92	Yes	Yes	1	9	6
23	R:R:L146	R:R:T63	17.5136	7.37	Yes	Yes	1	7	5
24	R:R:L146	R:R:V141	17.5175	2.98	Yes	Yes	1	7	6
25	R:R:C122	R:R:F67	21.0266	9.78	No	No	0	7	8
26	R:R:F67	R:R:L146	28.0486	3.65	No	Yes	0	8	7
27	R:R:C122	R:R:I153	17.5056	4.91	No	No	0	7	6
28	R:R:I153	R:R:S119	10.6539	3.1	No	No	0	6	8
29	R:R:S157	R:R:V115	11.8935	4.85	No	No	0	8	7
30	R:R:S114	R:R:S157	13.3589	3.26	No	No	0	6	8
31	R:R:F161	R:R:S114	14.5946	6.61	Yes	No	6	6	6
32	R:R:F161	R:R:I195	24.5198	8.79	Yes	No	0	6	6
33	R:R:I195	R:R:Y200	100	4.84	No	Yes	0	6	5
34	R:R:W265	R:R:Y200	75.1198	3.86	Yes	Yes	0	8	5
35	R:R:N296	R:R:W265	52.7031	6.78	No	Yes	0	9	8
36	R:R:F191	R:R:I195	86.5104	11.3	Yes	No	0	5	6
37	R:R:F191	R:R:S164	77.314	2.64	Yes	No	0	5	5
38	R:R:P171	R:R:S164	71.9474	7.13	No	No	0	3	5
39	R:R:P171	R:R:W185	44.7265	6.76	No	Yes	2	3	7
40	R:R:W180	R:R:W185	23.8623	3.75	Yes	Yes	0	3	7
41	R:R:C102	R:R:W180	18.4443	3.92	No	Yes	0	9	3
42	R:R:C102	R:R:F178	33.938	2.79	No	No	0	9	4
43	R:R:F178	R:R:S88	11.343	5.28	No	No	0	4	5
44	R:R:C181	R:R:W185	21.0503	7.84	No	Yes	0	9	7
45	R:R:C102	R:R:C181	18.3413	7.28	No	No	0	9	9
46	R:R:E98	R:R:F178	20.0127	7	No	No	0	7	4
47	R:R:E98	R:R:T101	17.1769	2.82	No	No	0	7	5
48	R:R:L94	R:R:T101	14.3332	4.42	No	No	0	4	5
49	R:R:F261	R:R:L120	62.9451	9.74	Yes	No	0	9	8
50	R:R:F261	R:R:M117	31.122	3.73	Yes	No	0	9	7
51	R:R:I123	R:R:R127	11.0935	3.76	Yes	No	1	9	9
52	R:R:R127	R:R:Y211	39.9382	7.2	No	Yes	1	9	9
53	R:R:S124	R:R:Y211	19.8622	5.09	No	Yes	0	8	9
54	R:R:R127	R:R:Y304	30.326	4.12	No	Yes	1	9	9
55	R:R:S124	R:R:T210	18.2502	7.99	No	No	0	8	6
56	R:R:T210	R:R:Y128	16.6304	7.49	No	Yes	0	6	8
57	R:R:K170	R:R:P171	26.1159	3.35	Yes	No	2	4	3
58	R:R:K170	R:R:T187	17.4344	7.51	Yes	Yes	2	4	5
59	R:R:D176	R:R:K170	10.0083	6.91	No	Yes	0	4	4
60	R:R:L254	R:R:Y211	11.5609	3.52	No	Yes	0	8	9
61	R:R:M71	R:R:N300	19.775	7.01	Yes	Yes	1	9	9
62	R:R:I123	R:R:Y304	36.6589	3.63	Yes	Yes	1	9	9
63	R:R:M117	R:R:Y200	30.4448	3.59	No	Yes	0	7	5
64	R:R:F261	R:R:W265	34.6707	5.01	Yes	Yes	0	9	8
65	R:R:L120	R:R:Y304	59.7647	7.03	No	Yes	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8HMV_nogp

PDB Summary
PDB	8HMV_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.64
Number of Linked Nodes	256
Number of Links	278
Number of Hubs	37
Number of Links mediated by Hubs	137
Number of Communities	9
Number of Nodes involved in Communities	50
Number of Links involved in Communities	65

Path Summary
Number Of Nodes in MetaPath	66
Number Of Links MetaPath	65
Number of Shortest Paths	48682
Length Of Smallest Path	3
Average Path Length	14.6548
Length of Longest Path	33
Minimum Path Strength	1.245
Average Path Strength	5.58165
Maximum Path Strength	19.82
Minimum Path Correlation	0.7
Average Path Correlation	0.933956
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	50.7867
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.4483
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • cellular response to nitrogen compound • response to peptide hormone • insulin receptor signaling pathway • cell surface receptor protein tyrosine kinase signaling pathway • cellular response to endogenous stimulus • response to hormone • enzyme-linked receptor protein signaling pathway • cellular response to hormone stimulus • cell surface receptor signaling pathway • response to endogenous stimulus • response to oxygen-containing compound • cellular response to peptide hormone stimulus • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • response to insulin • cellular response to insulin stimulus • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • developmental process • regulation of multicellular organism growth • multicellular organismal process • regulation of growth • regulation of developmental growth • regulation of developmental process • developmental growth • growth • positive regulation of biological process • positive regulation of multicellular organism growth • positive regulation of developmental process • multicellular organism growth • positive regulation of growth • positive regulation of multicellular organismal process • regulation of multicellular organismal process • positive regulation of developmental growth • negative regulation of signaling • negative regulation of biological process • regulation of signal transduction • regulation of cellular response to insulin stimulus • negative regulation of cell communication • negative regulation of cellular process • regulation of signaling • negative regulation of response to stimulus • regulation of insulin receptor signaling pathway • negative regulation of signal transduction • negative regulation of cellular response to insulin stimulus • regulation of response to stimulus • negative regulation of insulin receptor signaling pathway • regulation of cell communication • cell periphery • cellular anatomical structure • plasma membrane • membrane • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • response to glucagon • cellular response to glucagon stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • metabolic process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99679
Sequence	>8HMV_nogp_Chain_R L E V L I I V F L T V L I I S G N I I V I F V F H C A P L L N H H T T S Y F I Q T M A Y A D L F V G V S C V V P S L S L L H H P L P V E E S L T C Q I F G F V V S V L K S V S M A S L A C I S I D R Y I A I T K P L T Y N T L V T P W R L R L C I F L I W L Y S T L V F L P S F F H W G K P G Y H G D V F Q W C A E S W H T D S Y F T L F I V M M L Y A P A A L I V C F T Y F N I F R I C Q Q H T K D I S E R Q A R F S R Y A M V L F R I T S V F Y I L W L P Y I I Y F L L E S S T G H S N R F A S F L T T W L A I S N S F C N C V I Y S L S N S V F Q R G L K R L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HJ1	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	Gs/β1/γ2	3.27	2023-12-27	10.1038/s41467-023-35882-w
	8HJ1 (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		3.27	2023-12-27	10.1038/s41467-023-35882-w
	8HJ2	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	chim(Gs-CtG15)/β1/γ2	3.8	2023-03-15	10.1038/s41467-023-35882-w
	8HJ2 (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		3.8	2023-03-15	10.1038/s41467-023-35882-w
	8HJ0	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	chim(Gs-CtG15)/β1/γ2	3.12	2023-03-15	10.1038/s41467-023-35882-w
	8HJ0 (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		3.12	2023-03-15	10.1038/s41467-023-35882-w
	8HIX	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	Gs/β1/γ2	3.12	2023-03-15	10.1038/s41467-023-35882-w
	8HIX (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		3.12	2023-03-15	10.1038/s41467-023-35882-w
	8HMV	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	Gs/β1/γ2	2.91	2023-03-01	10.1002/mco2.205
	8HMV (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		2.91	2023-03-01	10.1002/mco2.205

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8HMV_nogp.zip

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