psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E31	R:R:F287	8.16	No	Yes	0	4	5
2	R:R:L89	R:R:V32	2.98	No	No	0	4	4
3	R:R:L90	R:R:V32	2.98	No	No	0	5	4
4	R:R:I34	R:R:L38	2.85	No	No	0	5	7
5	R:R:I35	R:R:W291	12.92	No	Yes	0	6	4
6	R:R:S86	R:R:V36	3.23	No	No	0	7	4
7	R:R:F37	R:R:L41	9.74	No	No	0	4	4
8	R:R:L38	R:R:S295	3	No	No	0	7	6
9	R:R:I43	R:R:T39	3.04	Yes	No	0	6	6
10	R:R:C82	R:R:T39	6.76	No	No	0	7	6
11	R:R:I42	R:R:N46	2.83	No	Yes	0	8	9
12	R:R:G79	R:R:I42	3.53	No	No	0	7	8
13	R:R:I43	R:R:I47	2.94	Yes	No	4	6	5
14	R:R:I43	R:R:L76	2.85	Yes	No	4	6	6
15	R:R:G79	R:R:I43	3.53	No	Yes	0	7	6
16	R:R:G45	R:R:S44	3.71	Yes	No	0	8	4
17	R:R:D75	R:R:N46	6.73	Yes	Yes	0	9	9
18	R:R:L76	R:R:N46	6.87	No	Yes	0	6	9
19	R:R:C301	R:R:N46	3.15	No	Yes	0	9	9
20	R:R:I47	R:R:L76	2.85	No	No	4	5	6
21	R:R:C301	R:R:V49	3.42	No	No	0	9	9
22	R:R:S305	R:R:V49	6.46	No	No	0	7	9
23	R:R:H54	R:R:I50	2.65	No	No	5	3	7
24	R:R:I50	R:R:Y73	6.04	No	No	5	7	6
25	R:R:F311	R:R:V52	14.42	Yes	No	0	9	8
26	R:R:L315	R:R:V52	2.98	No	No	0	6	8
27	R:R:F53	R:R:L59	4.87	No	No	0	7	9
28	R:R:F53	R:R:Q69	5.86	No	No	0	7	6
29	R:R:F311	R:R:F53	3.22	Yes	No	0	9	7
30	R:R:H54	R:R:Y73	4.36	No	No	5	3	6
31	R:R:P57	R:R:R317	5.76	No	No	0	6	4
32	R:R:H61	R:R:L58	9	No	No	0	8	5
33	R:R:N60	R:R:Q69	6.6	No	No	0	5	6
34	R:R:H62	R:R:T63	2.74	No	Yes	1	7	5
35	R:R:H62	R:R:Y137	8.71	No	Yes	1	7	7
36	R:R:D126	R:R:T63	8.67	Yes	Yes	1	9	5
37	R:R:T63	R:R:Y137	4.99	Yes	Yes	1	5	7
38	R:R:T63	R:R:V141	3.17	Yes	Yes	1	5	6
39	R:R:L146	R:R:T63	7.37	Yes	Yes	1	7	5
40	R:R:I68	R:R:T64	3.04	No	No	1	8	8
41	R:R:I123	R:R:T64	4.56	Yes	No	1	9	8
42	R:R:D126	R:R:T64	7.23	Yes	No	1	9	8
43	R:R:L146	R:R:Y66	8.21	Yes	No	0	7	4
44	R:R:C122	R:R:F67	9.78	No	No	0	7	8
45	R:R:F67	R:R:L146	3.65	No	Yes	0	8	7
46	R:R:C149	R:R:F67	5.59	No	No	0	6	8
47	R:R:I123	R:R:I68	2.94	Yes	No	1	9	8
48	R:R:S119	R:R:T70	3.2	No	No	0	8	9
49	R:R:I150	R:R:T70	6.08	No	No	0	8	9
50	R:R:D75	R:R:M71	4.16	Yes	Yes	1	9	9
51	R:R:I123	R:R:M71	2.92	Yes	Yes	1	9	9
52	R:R:M71	R:R:N300	7.01	Yes	Yes	1	9	9
53	R:R:M71	R:R:Y304	4.79	Yes	Yes	1	9	9
54	R:R:A74	R:R:V115	3.39	No	No	0	8	7
55	R:R:D75	R:R:S116	5.89	Yes	No	0	9	9
56	R:R:D75	R:R:S297	8.83	Yes	No	0	9	9
57	R:R:D75	R:R:N300	4.04	Yes	Yes	1	9	9
58	R:R:L112	R:R:V78	4.47	Yes	No	0	6	8
59	R:R:L87	R:R:V83	2.98	No	No	0	5	7
60	R:R:P85	R:R:V84	3.53	No	No	0	3	8
61	R:R:F105	R:R:P85	8.67	No	No	0	5	3
62	R:R:F178	R:R:S88	5.28	No	No	0	4	5
63	R:R:L89	R:R:V177	4.47	No	No	0	4	2
64	R:R:L94	R:R:P95	4.93	No	No	0	4	7
65	R:R:L94	R:R:V96	2.98	No	No	0	4	3
66	R:R:L94	R:R:T101	4.42	No	No	0	4	5
67	R:R:L100	R:R:V96	2.98	No	No	0	1	3
68	R:R:E97	R:R:S99	5.75	No	No	0	5	3
69	R:R:E98	R:R:T101	2.82	No	No	0	7	5
70	R:R:E98	R:R:F178	7	No	No	0	7	4
71	R:R:S99	R:R:W180	8.65	No	Yes	0	3	3
72	R:R:I104	R:R:L100	4.28	No	No	0	4	1
73	R:R:C102	R:R:F178	2.79	No	No	0	9	4
74	R:R:C102	R:R:W180	3.92	No	Yes	0	9	3
75	R:R:C102	R:R:C181	7.28	No	No	0	9	9
76	R:R:Q103	R:R:W185	16.43	No	Yes	0	5	7
77	R:R:F107	R:R:V111	6.55	No	No	0	6	5
78	R:R:F107	R:R:F165	10.72	No	No	0	6	5
79	R:R:L112	R:R:V108	2.98	Yes	No	0	6	4
80	R:R:H174	R:R:V109	5.54	Yes	No	0	4	6
81	R:R:F161	R:R:S110	5.28	Yes	No	0	6	4
82	R:R:H174	R:R:S110	6.97	Yes	No	0	4	4
83	R:R:H174	R:R:K113	9.17	Yes	Yes	3	4	6
84	R:R:K113	R:R:W265	5.8	Yes	Yes	3	6	8
85	R:R:K113	R:R:Y268	3.58	Yes	No	3	6	6
86	R:R:A293	R:R:K113	3.21	No	Yes	0	7	6
87	R:R:S114	R:R:S157	3.26	No	No	0	6	8
88	R:R:F161	R:R:S114	6.61	Yes	No	6	6	6
89	R:R:L199	R:R:S114	3	No	No	6	7	6
90	R:R:V115	R:R:W154	11.03	No	No	0	7	9
91	R:R:S157	R:R:V115	4.85	No	No	0	8	7
92	R:R:M117	R:R:Y200	3.59	No	Yes	0	7	5
93	R:R:A203	R:R:M117	3.22	No	No	0	6	7
94	R:R:F261	R:R:M117	3.73	Yes	No	0	9	7
95	R:R:A118	R:R:I153	3.25	No	No	0	4	6
96	R:R:I153	R:R:S119	3.1	No	No	0	6	8
97	R:R:F261	R:R:L120	9.74	Yes	No	0	9	8
98	R:R:L120	R:R:N300	4.12	No	Yes	0	8	9
99	R:R:L120	R:R:Y304	7.03	No	Yes	0	8	9
100	R:R:C122	R:R:I153	4.91	No	No	0	7	6
101	R:R:I123	R:R:R127	3.76	Yes	No	1	9	9
102	R:R:I123	R:R:Y304	3.63	Yes	Yes	1	9	9
103	R:R:S124	R:R:T210	7.99	No	No	0	8	6
104	R:R:S124	R:R:Y211	5.09	No	Yes	0	8	9
105	R:R:I125	R:R:I129	2.94	No	No	0	6	5
106	R:R:I125	R:R:I206	4.42	No	No	0	6	8
107	R:R:D126	R:R:Y137	8.05	Yes	Yes	1	9	7
108	R:R:D126	R:R:V141	2.92	Yes	Yes	1	9	6
109	R:R:R127	R:R:Y211	7.2	No	Yes	1	9	9
110	R:R:R127	R:R:Y304	4.12	No	Yes	1	9	9
111	R:R:T132	R:R:Y128	8.74	No	Yes	0	6	8
112	R:R:F209	R:R:Y128	6.19	No	Yes	7	4	8
113	R:R:T210	R:R:Y128	7.49	No	Yes	0	6	8
114	R:R:N213	R:R:Y128	8.14	No	Yes	7	5	8
115	R:R:I129	R:R:Y137	3.63	No	Yes	1	5	7
116	R:R:I129	R:R:V141	3.07	No	Yes	1	5	6
117	R:R:A130	R:R:Y137	9.34	No	Yes	0	8	7
118	R:R:I131	R:R:I214	4.42	No	No	0	9	9
119	R:R:I131	R:R:I217	2.94	No	No	0	9	6
120	R:R:K133	R:R:T136	3	Yes	No	0	5	4
121	R:R:K133	R:R:L140	2.82	Yes	No	0	5	4
122	R:R:N138	R:R:Y137	3.49	No	Yes	0	4	7
123	R:R:V141	R:R:Y137	5.05	Yes	Yes	1	6	7
124	R:R:L146	R:R:V141	2.98	Yes	Yes	1	7	6
125	R:R:P143	R:R:T142	3.5	No	No	0	3	8
126	R:R:R145	R:R:T142	10.35	No	No	0	5	8
127	R:R:P143	R:R:R147	4.32	No	No	0	3	1
128	R:R:L148	R:R:W144	3.42	No	No	0	2	4
129	R:R:L148	R:R:L152	5.54	No	No	0	2	3
130	R:R:V160	R:R:Y156	7.57	No	No	0	5	4
131	R:R:M198	R:R:Y156	4.79	No	No	0	6	4
132	R:R:L199	R:R:V160	11.92	No	No	0	7	5
133	R:R:F161	R:R:I195	8.79	Yes	No	0	6	6
134	R:R:F161	R:R:L199	3.65	Yes	No	6	6	7
135	R:R:P163	R:R:W168	10.81	No	No	0	5	5
136	R:R:F191	R:R:P163	5.78	Yes	No	0	5	5
137	R:R:F165	R:R:S164	2.64	No	No	0	5	5
138	R:R:P171	R:R:S164	7.13	No	No	0	3	5
139	R:R:F191	R:R:S164	2.64	Yes	No	0	5	5
140	R:R:K170	R:R:P171	3.35	Yes	No	2	4	3
141	R:R:D176	R:R:K170	6.91	No	Yes	0	4	4
142	R:R:K170	R:R:W185	23.21	Yes	Yes	2	4	7
143	R:R:K170	R:R:T187	7.51	Yes	Yes	2	4	5
144	R:R:P171	R:R:W185	6.76	No	Yes	2	3	7
145	R:R:G172	R:R:H174	3.18	No	Yes	0	1	4
146	R:R:D176	R:R:Y173	6.9	No	Yes	0	4	1
147	R:R:T187	R:R:Y173	6.24	Yes	Yes	2	5	1
148	R:R:Y173	R:R:Y271	5.96	Yes	No	2	1	5
149	R:R:F272	R:R:Y173	8.25	No	Yes	2	5	1
150	R:R:E275	R:R:Y173	13.47	Yes	Yes	2	2	1
151	R:R:H174	R:R:Y268	7.62	Yes	No	3	4	6
152	R:R:H174	R:R:T290	5.48	Yes	No	0	4	5
153	R:R:A182	R:R:D176	3.09	No	No	0	3	4
154	R:R:S184	R:R:W180	22.24	No	Yes	0	3	3
155	R:R:W180	R:R:W185	3.75	Yes	Yes	0	3	7
156	R:R:C181	R:R:W185	7.84	No	Yes	0	9	7
157	R:R:E275	R:R:T187	7.06	Yes	Yes	2	2	5
158	R:R:S276	R:R:T187	4.8	No	Yes	2	3	5
159	R:R:S189	R:R:Y190	7.63	No	No	0	4	7
160	R:R:F191	R:R:I195	11.3	Yes	No	0	5	6
161	R:R:F272	R:R:T192	16.86	No	No	2	5	4
162	R:R:S276	R:R:T192	9.59	No	No	2	3	4
163	R:R:F194	R:R:M198	7.46	No	No	0	6	6
164	R:R:I195	R:R:Y200	4.84	No	Yes	0	6	5
165	R:R:L273	R:R:V196	4.47	No	No	0	6	5
166	R:R:W265	R:R:Y200	3.86	Yes	Yes	0	8	5
167	R:R:I269	R:R:Y200	8.46	No	Yes	0	7	5
168	R:R:A204	R:R:Y262	2.67	No	Yes	0	3	6
169	R:R:V207	R:R:Y262	3.79	No	Yes	0	5	6
170	R:R:F209	R:R:N213	8.46	No	No	7	4	5
171	R:R:L254	R:R:Y211	3.52	No	Yes	0	8	9
172	R:R:I257	R:R:Y211	9.67	No	Yes	1	8	9
173	R:R:T258	R:R:Y211	4.99	No	Yes	1	7	9
174	R:R:F212	R:R:R216	6.41	No	No	0	3	3
175	R:R:F215	R:R:Q219	3.51	No	No	8	6	5
176	R:R:F215	R:R:Y250	7.22	No	Yes	8	6	8
177	R:R:F215	R:R:L254	3.65	No	No	0	6	8
178	R:R:C218	R:R:Y250	6.72	No	Yes	0	8	8
179	R:R:Q219	R:R:Y250	5.64	No	Yes	8	5	8
180	R:R:H221	R:R:Q220	4.95	No	No	0	7	4
181	R:R:E227	R:R:K223	2.7	No	No	0	3	4
182	R:R:F232	R:R:R231	5.34	No	No	0	4	6
183	R:R:F255	R:R:S259	5.28	No	No	0	5	4
184	R:R:I257	R:R:T258	3.04	No	No	1	8	7
185	R:R:L264	R:R:V260	2.98	Yes	Yes	9	8	6
186	R:R:C299	R:R:V260	3.42	No	Yes	9	5	6
187	R:R:I303	R:R:V260	4.61	No	Yes	0	8	6
188	R:R:F261	R:R:Y262	8.25	Yes	Yes	0	9	6
189	R:R:F261	R:R:W265	5.01	Yes	Yes	0	9	8
190	R:R:L266	R:R:Y262	3.52	No	Yes	0	6	6
191	R:R:I263	R:R:L264	2.85	No	Yes	0	5	8
192	R:R:L264	R:R:L292	4.15	Yes	No	0	8	6
193	R:R:L264	R:R:N296	10.98	Yes	No	0	8	9
194	R:R:C299	R:R:L264	3.17	No	Yes	9	5	8
195	R:R:W265	R:R:Y268	2.89	Yes	No	3	8	6
196	R:R:N296	R:R:W265	6.78	No	Yes	0	9	8
197	R:R:P267	R:R:T289	3.5	No	No	0	9	5
198	R:R:E275	R:R:Y271	10.1	Yes	No	2	2	5
199	R:R:S286	R:R:Y271	5.09	No	No	0	4	5
200	R:R:F272	R:R:S276	2.64	No	No	2	5	3
201	R:R:E275	R:R:S281	4.31	Yes	No	0	2	3
202	R:R:G279	R:R:T278	3.64	No	No	0	1	4
203	R:R:F284	R:R:N282	7.25	No	No	0	1	4
204	R:R:A285	R:R:N282	3.13	No	No	0	4	4
205	R:R:F284	R:R:R283	7.48	No	No	0	1	3
206	R:R:F287	R:R:W291	12.03	Yes	Yes	0	5	4
207	R:R:I294	R:R:W291	12.92	No	Yes	0	7	4
208	R:R:L292	R:R:S295	3	No	No	0	6	6
209	R:R:N296	R:R:N300	12.26	No	Yes	0	9	9
210	R:R:L306	R:R:V302	5.96	No	No	0	5	6
211	R:R:I303	R:R:Y304	4.84	No	Yes	0	8	9
212	R:R:F311	R:R:S305	3.96	Yes	No	0	9	7
213	R:R:N308	R:R:V310	4.43	No	No	0	8	6
214	R:R:F287	R:R:V177	2.62	Yes	No	0	5	2
215	R:R:C82	R:R:W291	2.61	No	Yes	0	7	4
216	R:R:H92	R:R:L90	2.57	No	No	0	4	5
217	R:R:F51	R:R:I47	2.51	No	No	0	4	5
218	R:R:T222	R:R:Y250	2.5	No	Yes	0	5	8
219	R:R:F298	R:R:L41	2.44	No	No	0	6	4
220	R:R:F77	R:R:L112	2.44	No	Yes	0	7	6
221	R:R:F287	R:R:L288	2.44	Yes	No	0	5	4
222	R:R:I214	R:R:Y211	2.42	No	Yes	0	9	9
223	R:R:F311	R:R:N308	2.42	Yes	No	0	9	8
224	R:R:H61	R:R:H62	2.39	No	No	0	8	7
225	R:R:L112	R:R:W154	2.28	Yes	No	0	6	9
226	R:R:R145	R:R:W144	2	No	No	0	5	4
227	R:R:C301	R:R:G45	1.96	No	Yes	0	9	8
228	R:R:C181	R:R:G175	1.96	No	No	0	9	3
229	R:R:A56	R:R:P57	1.87	No	No	0	5	6
230	R:R:A201	R:R:P202	1.87	No	No	0	4	9
231	R:R:G106	R:R:S110	1.86	No	No	0	4	4
232	R:R:A121	R:R:A203	1.79	No	No	0	7	6
233	R:R:G45	R:R:I48	1.76	Yes	No	0	8	7
234	R:R:A72	R:R:V49	1.7	No	No	0	9	9
235	R:R:D188	R:R:G169	1.68	No	No	0	3	5
236	R:R:K133	R:R:P134	1.67	Yes	No	0	5	8
237	R:R:L162	R:R:P163	1.64	No	No	0	4	5
238	R:R:L266	R:R:P267	1.64	No	No	0	6	9
239	R:R:A72	R:R:I50	1.62	No	No	0	9	7
240	R:R:S81	R:R:V108	1.62	No	No	0	5	4
241	R:R:S88	R:R:V84	1.62	No	No	0	5	8
242	R:R:S259	R:R:V260	1.62	No	Yes	0	4	6
243	R:R:S309	R:R:V310	1.62	No	No	0	4	6
244	R:R:V32	R:R:V36	1.6	No	No	0	4	4
245	R:R:S226	R:R:T222	1.6	No	No	0	3	5
246	R:R:S277	R:R:T278	1.6	No	No	0	4	4
247	R:R:T39	R:R:V83	1.59	No	No	0	6	7
248	R:R:T158	R:R:V111	1.59	No	No	0	3	5
249	R:R:A56	R:R:L318	1.58	No	No	0	5	6
250	R:R:I269	R:R:V196	1.54	No	No	0	7	5
251	R:R:I303	R:R:V302	1.54	No	No	0	8	6
252	R:R:H92	R:R:P93	1.53	No	No	0	4	4
253	R:R:F298	R:R:G45	1.51	No	Yes	0	6	8
254	R:R:F191	R:R:G169	1.51	Yes	No	0	5	5
255	R:R:A182	R:R:E183	1.51	No	No	0	3	5
256	R:R:K133	R:R:T132	1.5	Yes	No	0	5	6
257	R:R:G314	R:R:R313	1.5	No	No	0	7	4
258	R:R:G314	R:R:R317	1.5	No	No	0	7	4
259	R:R:D188	R:R:S189	1.47	No	No	0	3	4
260	R:R:I270	R:R:L274	1.43	No	No	0	7	4
261	R:R:L193	R:R:M197	1.41	No	No	0	4	4
262	R:R:K316	R:R:L315	1.41	No	No	0	5	6
263	R:R:C55	R:R:F51	1.4	No	No	0	5	4
264	R:R:L152	R:R:L155	1.38	No	No	0	3	3
265	R:R:L193	R:R:L273	1.38	No	No	0	4	6
266	R:R:D224	R:R:K223	1.38	No	No	0	4	4
267	R:R:I225	R:R:Q229	1.37	No	No	0	6	3
268	R:R:H280	R:R:T278	1.37	No	No	0	1	4
269	R:R:C208	R:R:Y262	1.34	No	Yes	0	6	6
270	R:R:E31	R:R:L30	1.33	No	No	0	4	5
271	R:R:R256	R:R:S307	1.32	No	No	0	6	7
272	R:R:R313	R:R:S309	1.32	No	No	0	4	4
273	R:R:R249	R:R:V253	1.31	No	No	0	8	8
274	R:R:R256	R:R:V253	1.31	No	No	0	6	8
275	R:R:F255	R:R:M252	1.24	No	No	0	5	7
276	R:R:F212	R:R:N213	1.21	No	No	0	3	5
277	R:R:E31	R:R:R283	1.16	No	No	0	4	3
278	R:R:F166	R:R:W168	1	No	No	0	3	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I43	3.09	4	4	6
2	R:R:G45	2.235	4	0	8
3	R:R:N46	4.895	4	0	9
4	R:R:T63	5.388	5	1	5
5	R:R:M71	4.72	4	1	9
6	R:R:D75	5.93	5	1	9
7	R:R:L112	3.0425	4	0	6
8	R:R:K113	5.44	4	3	6
9	R:R:I123	3.562	5	1	9
10	R:R:D126	6.7175	4	1	9
11	R:R:Y128	7.64	4	7	8
12	R:R:K133	2.2475	4	0	5
13	R:R:Y137	6.18	7	1	7
14	R:R:V141	3.438	5	1	6
15	R:R:L146	5.5525	4	1	7
16	R:R:F161	6.0825	4	6	6
17	R:R:K170	10.245	4	2	4
18	R:R:Y173	8.164	5	2	1
19	R:R:H174	6.32667	6	3	4
20	R:R:W180	9.64	4	0	3
21	R:R:W185	11.598	5	2	7
22	R:R:T187	6.4025	4	2	5
23	R:R:F191	5.3075	4	0	5
24	R:R:Y200	5.1875	4	0	5
25	R:R:Y211	5.48167	6	1	9
26	R:R:Y250	5.52	4	8	8
27	R:R:V260	3.1575	4	9	6
28	R:R:F261	6.6825	4	0	9
29	R:R:Y262	3.914	5	0	6
30	R:R:L264	4.826	5	9	8
31	R:R:W265	4.868	5	3	8
32	R:R:E275	8.735	4	2	2
33	R:R:F287	6.3125	4	0	5
34	R:R:W291	10.12	4	0	4
35	R:R:N300	6.8575	4	1	9
36	R:R:Y304	4.882	5	1	9
37	R:R:F311	6.005	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F287	R:R:W291	17.705	12.03	Yes	Yes	0	5	4
2	R:R:C82	R:R:W291	20.8338	2.61	No	Yes	0	7	4
3	R:R:C82	R:R:T39	21.8781	6.76	No	No	0	7	6
4	R:R:I43	R:R:T39	24.9159	3.04	Yes	No	0	6	6
5	R:R:I43	R:R:L76	25.442	2.85	Yes	No	4	6	6
6	R:R:L76	R:R:N46	29.6151	6.87	No	Yes	0	6	9
7	R:R:D75	R:R:N46	57.2327	6.73	Yes	Yes	0	9	9
8	R:R:D75	R:R:N300	33.5232	4.04	Yes	Yes	1	9	9
9	R:R:N296	R:R:N300	50.1642	12.26	No	Yes	0	9	9
10	R:R:L264	R:R:N296	10.498	10.98	Yes	No	0	8	9
11	R:R:C301	R:R:N46	31.9172	3.15	No	Yes	0	9	9
12	R:R:C301	R:R:V49	25.1058	3.42	No	No	0	9	9
13	R:R:S305	R:R:V49	20.0032	6.46	No	No	0	7	9
14	R:R:F311	R:R:S305	18.9589	3.96	Yes	No	0	9	7
15	R:R:F311	R:R:N308	10.32	2.42	Yes	No	0	9	8
16	R:R:D75	R:R:M71	25.7703	4.16	Yes	Yes	1	9	9
17	R:R:I123	R:R:M71	36.2248	2.92	Yes	Yes	1	9	9
18	R:R:I123	R:R:T64	67.1018	4.56	Yes	No	1	9	8
19	R:R:D126	R:R:T64	65.6817	7.23	Yes	No	1	9	8
20	R:R:D126	R:R:T63	24.2514	8.67	Yes	Yes	1	9	5
21	R:R:D126	R:R:Y137	15.5888	8.05	Yes	Yes	1	9	7
22	R:R:D126	R:R:V141	24.2514	2.92	Yes	Yes	1	9	6
23	R:R:L146	R:R:T63	17.5982	7.37	Yes	Yes	1	7	5
24	R:R:L146	R:R:V141	17.5982	2.98	Yes	Yes	1	7	6
25	R:R:C122	R:R:F67	21.2136	9.78	No	No	0	7	8
26	R:R:F67	R:R:L146	28.2228	3.65	No	Yes	0	8	7
27	R:R:C122	R:R:I153	17.6971	4.91	No	No	0	7	6
28	R:R:I153	R:R:S119	10.6404	3.1	No	No	0	6	8
29	R:R:S157	R:R:V115	11.8785	4.85	No	No	0	8	7
30	R:R:S114	R:R:S157	13.342	3.26	No	No	0	6	8
31	R:R:F161	R:R:S114	14.5762	6.61	Yes	No	6	6	6
32	R:R:F161	R:R:I195	24.4887	8.79	Yes	No	0	6	6
33	R:R:I195	R:R:Y200	100	4.84	No	Yes	0	6	5
34	R:R:W265	R:R:Y200	75.088	3.86	Yes	Yes	0	8	5
35	R:R:N296	R:R:W265	52.6364	6.78	No	Yes	0	9	8
36	R:R:F191	R:R:I195	86.5116	11.3	Yes	No	0	5	6
37	R:R:F191	R:R:S164	77.3268	2.64	Yes	No	0	5	5
38	R:R:P171	R:R:S164	71.9513	7.13	No	No	0	3	5
39	R:R:P171	R:R:W185	44.7016	6.76	No	Yes	2	3	7
40	R:R:W180	R:R:W185	23.8479	3.75	Yes	Yes	0	3	7
41	R:R:C102	R:R:W180	18.4368	3.92	No	Yes	0	9	3
42	R:R:C102	R:R:F178	33.9267	2.79	No	No	0	9	4
43	R:R:F178	R:R:S88	11.3603	5.28	No	No	0	4	5
44	R:R:C181	R:R:W185	21.0395	7.84	No	Yes	0	9	7
45	R:R:C102	R:R:C181	18.3339	7.28	No	No	0	9	9
46	R:R:E98	R:R:F178	19.9873	7	No	No	0	7	4
47	R:R:E98	R:R:T101	17.1552	2.82	No	No	0	7	5
48	R:R:L94	R:R:T101	14.3151	4.42	No	No	0	4	5
49	R:R:F261	R:R:L120	63.0632	9.74	Yes	No	0	9	8
50	R:R:F261	R:R:M117	31.1459	3.73	Yes	No	0	9	7
51	R:R:I123	R:R:R127	11.0874	3.76	Yes	No	1	9	9
52	R:R:R127	R:R:Y211	39.8956	7.2	No	Yes	1	9	9
53	R:R:S124	R:R:Y211	19.837	5.09	No	Yes	0	8	9
54	R:R:R127	R:R:Y304	30.2876	4.12	No	Yes	1	9	9
55	R:R:S124	R:R:T210	18.2271	7.99	No	No	0	8	6
56	R:R:T210	R:R:Y128	16.6093	7.49	No	Yes	0	6	8
57	R:R:K170	R:R:P171	26.1461	3.35	Yes	No	2	4	3
58	R:R:K170	R:R:T187	17.4281	7.51	Yes	Yes	2	4	5
59	R:R:D176	R:R:K170	10.0431	6.91	No	Yes	0	4	4
60	R:R:L254	R:R:Y211	11.5541	3.52	No	Yes	0	8	9
61	R:R:M71	R:R:N300	19.75	7.01	Yes	Yes	1	9	9
62	R:R:I123	R:R:Y304	36.8103	3.63	Yes	Yes	1	9	9
63	R:R:M117	R:R:Y200	30.4695	3.59	No	Yes	0	7	5
64	R:R:F261	R:R:W265	34.7613	5.01	Yes	Yes	0	9	8
65	R:R:L120	R:R:Y304	59.8869	7.03	No	Yes	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8HMV_nogp

PDB Summary
PDB	8HMV_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.64
Number of Linked Nodes	256
Number of Links	278
Number of Hubs	37
Number of Links mediated by Hubs	137
Number of Communities	9
Number of Nodes involved in Communities	50
Number of Links involved in Communities	65

Path Summary
Number Of Nodes in MetaPath	66
Number Of Links MetaPath	65
Number of Shortest Paths	48736
Length Of Smallest Path	3
Average Path Length	14.6579
Length of Longest Path	33
Minimum Path Strength	1.245
Average Path Strength	5.58203
Maximum Path Strength	19.82
Minimum Path Correlation	0.7
Average Path Correlation	0.933706
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	50.9041
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.4539
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99679
Sequence	>8HMV_nogp_Chain_R L E V L I I V F L T V L I I S G N I I V I F V F H C A P L L N H H T T S Y F I Q T M A Y A D L F V G V S C V V P S L S L L H H P L P V E E S L T C Q I F G F V V S V L K S V S M A S L A C I S I D R Y I A I T K P L T Y N T L V T P W R L R L C I F L I W L Y S T L V F L P S F F H W G K P G Y H G D V F Q W C A E S W H T D S Y F T L F I V M M L Y A P A A L I V C F T Y F N I F R I C Q Q H T K D I S E R Q A R F S R Y A M V L F R I T S V F Y I L W L P Y I I Y F L L E S S T G H S N R F A S F L T T W L A I S N S F C N C V I Y S L S N S V F Q R G L K R L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HMV	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	Gs/β1/γ2	2.91	2023-03-01	doi.org/10.1002/mco2.205
	8HMV (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		2.91	2023-03-01	doi.org/10.1002/mco2.205
	8HIX	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	Gs/β1/γ2	3.12	2023-03-15	doi.org/10.1038/s41467-023-35882-w
	8HIX (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		3.12	2023-03-15	doi.org/10.1038/s41467-023-35882-w
	8HJ0	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	chim(Gs-CtG15)/β1/γ2	3.12	2023-03-15	doi.org/10.1038/s41467-023-35882-w
	8HJ0 (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		3.12	2023-03-15	doi.org/10.1038/s41467-023-35882-w
	8HJ2	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	chim(Gs-CtG15)/β1/γ2	3.8	2023-03-15	doi.org/10.1038/s41467-023-35882-w
	8HJ2 (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		3.8	2023-03-15	doi.org/10.1038/s41467-023-35882-w
	8HJ1	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	Gs/β1/γ2	3.27	2023-12-27	doi.org/10.1038/s41467-023-35882-w
	8HJ1 (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		3.27	2023-12-27	doi.org/10.1038/s41467-023-35882-w

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8HMV_nogp.zip

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