psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C28	R:R:V25	10.25	No	No	0	4	3
2	R:R:L90	R:R:V25	4.47	No	No	0	5	3
3	R:R:F27	R:R:L30	7.31	No	No	0	1	5
4	R:R:E31	R:R:F284	11.66	No	No	0	4	1
5	R:R:I35	R:R:V32	6.14	Yes	No	6	6	4
6	R:R:L89	R:R:V32	8.94	No	No	6	4	4
7	R:R:I34	R:R:L33	4.28	No	No	0	5	5
8	R:R:I34	R:R:L38	2.85	No	No	0	5	7
9	R:R:I35	R:R:V36	4.61	Yes	No	0	6	4
10	R:R:I35	R:R:S86	6.19	Yes	No	0	6	7
11	R:R:I35	R:R:L89	4.28	Yes	No	6	6	4
12	R:R:I35	R:R:W291	11.74	Yes	No	0	6	4
13	R:R:I294	R:R:L38	4.28	Yes	No	0	7	7
14	R:R:L38	R:R:S295	6.01	No	No	0	7	6
15	R:R:I43	R:R:T39	3.04	Yes	Yes	7	6	6
16	R:R:C82	R:R:T39	8.45	No	Yes	0	7	6
17	R:R:T39	R:R:V83	3.17	Yes	No	7	6	7
18	R:R:S86	R:R:T39	3.2	No	Yes	0	7	6
19	R:R:L41	R:R:V40	2.98	No	No	0	4	5
20	R:R:F298	R:R:L41	13.4	No	No	0	6	4
21	R:R:D75	R:R:I42	2.8	No	No	0	9	8
22	R:R:I294	R:R:I42	2.94	Yes	No	0	7	8
23	R:R:F298	R:R:I42	10.05	No	No	0	6	8
24	R:R:I43	R:R:I47	2.94	Yes	No	0	6	5
25	R:R:G79	R:R:I43	3.53	No	Yes	0	7	6
26	R:R:I43	R:R:V83	3.07	Yes	No	7	6	7
27	R:R:C301	R:R:G45	3.92	No	No	0	9	8
28	R:R:N46	R:R:V49	2.96	Yes	No	0	9	9
29	R:R:I50	R:R:N46	8.5	No	Yes	8	7	9
30	R:R:A72	R:R:N46	3.13	No	Yes	8	9	9
31	R:R:D75	R:R:N46	14.81	No	Yes	0	9	9
32	R:R:L76	R:R:N46	8.24	No	Yes	0	6	9
33	R:R:C301	R:R:V49	3.42	No	No	0	9	9
34	R:R:F311	R:R:V49	2.62	Yes	No	0	9	9
35	R:R:A72	R:R:I50	3.25	No	No	8	9	7
36	R:R:C55	R:R:F51	5.59	No	No	0	5	4
37	R:R:F51	R:R:L318	2.44	No	Yes	0	4	6
38	R:R:F51	R:R:M322	2.49	No	No	0	4	3
39	R:R:F311	R:R:V52	15.73	Yes	No	0	9	8
40	R:R:L318	R:R:V52	4.47	Yes	No	0	6	8
41	R:R:F53	R:R:L59	12.18	Yes	No	3	7	9
42	R:R:F53	R:R:S65	7.93	Yes	No	0	7	9
43	R:R:F53	R:R:I68	8.79	Yes	No	0	7	8
44	R:R:F53	R:R:Q69	5.86	Yes	No	0	7	6
45	R:R:F53	R:R:Y304	3.09	Yes	Yes	3	7	9
46	R:R:F311	R:R:F53	7.5	Yes	Yes	3	9	7
47	R:R:A56	R:R:L59	6.3	No	No	0	5	9
48	R:R:H61	R:R:L58	10.29	No	No	0	8	5
49	R:R:F311	R:R:L59	6.09	Yes	No	3	9	9
50	R:R:N60	R:R:Y66	4.65	No	No	0	5	4
51	R:R:N60	R:R:Q69	6.6	No	No	0	5	6
52	R:R:D126	R:R:T63	7.23	Yes	No	4	9	5
53	R:R:T63	R:R:Y137	4.99	No	Yes	4	5	7
54	R:R:I68	R:R:T64	3.04	No	No	0	8	8
55	R:R:D126	R:R:T64	2.89	Yes	No	0	9	8
56	R:R:L146	R:R:Y66	8.21	No	No	0	7	4
57	R:R:C122	R:R:F67	5.59	No	No	10	7	8
58	R:R:F67	R:R:I123	7.54	No	No	0	8	9
59	R:R:C149	R:R:F67	2.79	No	No	10	6	8
60	R:R:I150	R:R:T70	7.6	No	No	0	8	9
61	R:R:M71	R:R:S119	7.67	No	No	11	9	8
62	R:R:L120	R:R:M71	4.24	No	No	11	8	9
63	R:R:M71	R:R:N300	2.8	No	No	0	9	9
64	R:R:D75	R:R:S297	7.36	No	No	0	9	9
65	R:R:F77	R:R:L112	7.31	No	Yes	0	7	6
66	R:R:L112	R:R:V78	4.47	Yes	No	0	6	8
67	R:R:S81	R:R:V108	4.85	No	No	0	5	4
68	R:R:P85	R:R:V84	3.53	No	No	0	3	8
69	R:R:F105	R:R:P85	14.45	Yes	No	0	5	3
70	R:R:H91	R:R:L87	9	No	No	0	4	5
71	R:R:H92	R:R:S88	9.76	No	No	0	4	5
72	R:R:L89	R:R:V177	4.47	No	No	0	4	2
73	R:R:H91	R:R:L90	6.43	No	No	0	4	5
74	R:R:H91	R:R:P93	6.1	No	No	0	4	4
75	R:R:H92	R:R:V96	9.69	No	No	0	4	3
76	R:R:L94	R:R:P93	4.93	No	No	0	4	4
77	R:R:L94	R:R:P95	4.93	No	No	0	4	7
78	R:R:E97	R:R:T101	4.23	No	No	0	5	5
79	R:R:C102	R:R:E98	4.56	No	No	0	9	7
80	R:R:L100	R:R:Q103	3.99	No	Yes	0	1	5
81	R:R:C102	R:R:F178	12.57	No	Yes	0	9	4
82	R:R:I104	R:R:Q103	2.74	No	Yes	0	4	5
83	R:R:K170	R:R:Q103	23.05	Yes	Yes	2	4	5
84	R:R:F178	R:R:Q103	3.51	Yes	Yes	2	4	5
85	R:R:Q103	R:R:W180	5.48	Yes	Yes	2	5	3
86	R:R:F165	R:R:I104	3.77	No	No	0	5	4
87	R:R:F105	R:R:G106	4.52	Yes	No	0	5	4
88	R:R:F105	R:R:V109	2.62	Yes	No	0	5	6
89	R:R:F105	R:R:G175	4.52	Yes	No	0	5	3
90	R:R:F107	R:R:V111	3.93	No	No	0	6	5
91	R:R:F107	R:R:L162	3.65	No	No	0	6	4
92	R:R:F107	R:R:S164	3.96	No	No	0	6	5
93	R:R:L112	R:R:V108	2.98	Yes	No	0	6	4
94	R:R:H174	R:R:V109	13.84	Yes	No	0	4	6
95	R:R:F161	R:R:S110	5.28	Yes	No	1	6	4
96	R:R:P171	R:R:S110	5.34	Yes	No	1	3	4
97	R:R:K113	R:R:S297	6.12	No	No	0	6	9
98	R:R:S114	R:R:S157	3.26	No	No	0	6	8
99	R:R:F161	R:R:S114	6.61	Yes	No	1	6	6
100	R:R:L199	R:R:S114	3	No	No	1	7	6
101	R:R:V115	R:R:W154	8.58	No	No	0	7	9
102	R:R:S157	R:R:V115	4.85	No	No	0	8	7
103	R:R:M117	R:R:Y200	4.79	Yes	Yes	1	7	5
104	R:R:A203	R:R:M117	3.22	No	Yes	0	6	7
105	R:R:F261	R:R:M117	6.22	No	Yes	0	9	7
106	R:R:M117	R:R:W265	9.31	Yes	No	1	7	8
107	R:R:A118	R:R:I153	3.25	No	No	0	4	6
108	R:R:L120	R:R:S119	3	No	No	11	8	8
109	R:R:L120	R:R:T258	4.42	No	No	0	8	7
110	R:R:C122	R:R:C149	5.46	No	No	10	7	6
111	R:R:I123	R:R:L254	2.85	No	No	0	9	8
112	R:R:I125	R:R:S124	3.1	No	No	0	6	8
113	R:R:S124	R:R:T210	9.59	No	No	0	8	6
114	R:R:I125	R:R:I206	4.42	No	No	0	6	8
115	R:R:D126	R:R:R127	3.57	Yes	No	4	9	9
116	R:R:D126	R:R:Y137	8.05	Yes	Yes	4	9	7
117	R:R:A130	R:R:R127	5.53	No	No	4	8	9
118	R:R:R127	R:R:Y137	7.2	No	Yes	4	9	7
119	R:R:T132	R:R:Y128	8.74	No	No	0	6	8
120	R:R:F209	R:R:Y128	4.13	No	No	0	4	8
121	R:R:I129	R:R:Y137	4.84	No	Yes	0	5	7
122	R:R:A130	R:R:Y137	6.67	No	Yes	4	8	7
123	R:R:I131	R:R:I217	4.42	No	No	0	9	6
124	R:R:K133	R:R:T132	4.5	No	No	0	5	6
125	R:R:K133	R:R:T136	3	No	No	0	5	4
126	R:R:T136	R:R:T139	3.14	No	No	13	4	4
127	R:R:L140	R:R:T136	2.95	No	No	13	4	4
128	R:R:V141	R:R:Y137	10.09	No	Yes	0	6	7
129	R:R:L140	R:R:T139	4.42	No	No	13	4	4
130	R:R:R145	R:R:T142	6.47	No	No	0	5	8
131	R:R:P143	R:R:R147	8.65	No	No	0	3	1
132	R:R:L148	R:R:L152	2.77	No	No	0	2	3
133	R:R:C149	R:R:I153	3.27	No	No	0	6	6
134	R:R:I150	R:R:W154	3.52	No	No	0	8	9
135	R:R:F151	R:R:L152	2.44	No	No	0	4	3
136	R:R:F151	R:R:L155	6.09	No	No	0	4	3
137	R:R:V160	R:R:Y156	8.83	Yes	No	1	5	4
138	R:R:M198	R:R:Y156	4.79	No	No	1	6	4
139	R:R:F161	R:R:V160	9.18	Yes	Yes	1	6	5
140	R:R:I195	R:R:V160	3.07	No	Yes	1	6	5
141	R:R:M198	R:R:V160	3.04	No	Yes	1	6	5
142	R:R:L199	R:R:V160	4.47	No	Yes	1	7	5
143	R:R:F161	R:R:P171	10.11	Yes	Yes	1	6	3
144	R:R:F161	R:R:I195	8.79	Yes	No	1	6	6
145	R:R:F161	R:R:L199	2.44	Yes	No	1	6	7
146	R:R:L162	R:R:P163	3.28	No	No	0	4	5
147	R:R:F165	R:R:L162	2.44	No	No	0	5	4
148	R:R:K170	R:R:S164	3.06	Yes	No	0	4	5
149	R:R:P171	R:R:S164	3.56	Yes	No	0	3	5
150	R:R:F166	R:R:H167	5.66	No	No	0	3	4
151	R:R:H167	R:R:W168	4.23	No	No	0	4	5
152	R:R:D188	R:R:W168	6.7	No	No	0	3	5
153	R:R:G169	R:R:W185	5.63	No	Yes	0	5	7
154	R:R:K170	R:R:W180	4.64	Yes	Yes	2	4	3
155	R:R:C181	R:R:K170	3.23	No	Yes	0	9	4
156	R:R:K170	R:R:W185	18.57	Yes	Yes	2	4	7
157	R:R:F191	R:R:P171	8.67	No	Yes	0	5	3
158	R:R:D176	R:R:Y173	9.2	No	Yes	0	4	1
159	R:R:W185	R:R:Y173	3.86	Yes	Yes	2	7	1
160	R:R:T187	R:R:Y173	4.99	No	Yes	2	5	1
161	R:R:F272	R:R:Y173	6.19	No	Yes	0	5	1
162	R:R:E275	R:R:Y173	6.73	Yes	Yes	2	2	1
163	R:R:S286	R:R:Y173	2.54	No	Yes	2	4	1
164	R:R:H174	R:R:Y268	4.36	Yes	Yes	12	4	6
165	R:R:H174	R:R:T290	6.85	Yes	No	12	4	5
166	R:R:H174	R:R:I294	2.65	Yes	Yes	0	4	7
167	R:R:F287	R:R:V177	3.93	No	No	0	5	2
168	R:R:F178	R:R:W180	13.03	Yes	Yes	2	4	3
169	R:R:C181	R:R:F178	18.15	No	Yes	0	9	4
170	R:R:S184	R:R:W180	9.88	No	Yes	0	3	3
171	R:R:T187	R:R:W185	6.06	No	Yes	2	5	7
172	R:R:T187	R:R:T192	3.14	No	No	0	5	4
173	R:R:D188	R:R:Y190	11.49	No	No	0	3	7
174	R:R:D188	R:R:F191	3.58	No	No	0	3	5
175	R:R:S189	R:R:S276	3.26	No	No	0	4	3
176	R:R:F191	R:R:I195	5.02	No	No	0	5	6
177	R:R:F272	R:R:T192	7.78	No	No	0	5	4
178	R:R:S276	R:R:T192	6.4	No	No	0	3	4
179	R:R:V196	R:R:Y200	6.31	Yes	Yes	0	5	5
180	R:R:L273	R:R:V196	2.98	No	Yes	0	6	5
181	R:R:W265	R:R:Y200	17.36	No	Yes	1	8	5
182	R:R:I269	R:R:Y200	4.84	Yes	Yes	1	7	5
183	R:R:A204	R:R:Y262	2.67	No	No	0	3	6
184	R:R:V207	R:R:Y211	2.52	No	Yes	0	5	9
185	R:R:F209	R:R:N213	7.25	No	No	0	4	5
186	R:R:T210	R:R:Y211	6.24	No	Yes	0	6	9
187	R:R:F215	R:R:Y211	3.09	No	Yes	5	6	9
188	R:R:M252	R:R:Y211	3.59	No	Yes	5	7	9
189	R:R:F255	R:R:Y211	6.19	Yes	Yes	5	5	9
190	R:R:T258	R:R:Y211	9.99	No	Yes	0	7	9
191	R:R:F212	R:R:N213	4.83	No	No	0	3	5
192	R:R:F215	R:R:M252	13.68	No	No	5	6	7
193	R:R:F215	R:R:F255	7.5	No	Yes	5	6	5
194	R:R:D224	R:R:Q220	5.22	No	No	0	4	4
195	R:R:H221	R:R:I225	5.3	No	No	0	7	6
196	R:R:D224	R:R:K223	12.44	No	No	0	4	4
197	R:R:E227	R:R:R231	17.45	No	No	0	3	6
198	R:R:R228	R:R:R231	8.53	No	No	0	3	6
199	R:R:F255	R:R:M252	4.98	Yes	No	5	5	7
200	R:R:S307	R:R:V253	6.46	No	No	0	7	8
201	R:R:F255	R:R:R256	5.34	Yes	No	0	5	6
202	R:R:F255	R:R:S259	2.64	Yes	No	0	5	4
203	R:R:I257	R:R:N300	4.25	No	No	0	8	9
204	R:R:I257	R:R:I303	7.36	No	No	0	8	8
205	R:R:N296	R:R:V260	4.43	No	No	0	9	6
206	R:R:F261	R:R:Y262	5.16	No	No	0	9	6
207	R:R:F261	R:R:N296	15.71	No	No	0	9	9
208	R:R:L264	R:R:N296	6.87	No	No	0	8	9
209	R:R:I269	R:R:W265	17.62	Yes	No	1	7	8
210	R:R:I270	R:R:L266	4.28	No	No	0	7	6
211	R:R:P267	R:R:Y271	2.78	No	Yes	0	9	5
212	R:R:F272	R:R:Y268	10.32	No	Yes	0	5	6
213	R:R:T290	R:R:Y268	2.5	No	Yes	12	5	6
214	R:R:A293	R:R:Y268	4	No	Yes	0	7	6
215	R:R:I269	R:R:L273	2.85	Yes	No	0	7	6
216	R:R:T289	R:R:Y271	3.75	No	Yes	0	5	5
217	R:R:E275	R:R:S281	5.75	Yes	No	0	2	3
218	R:R:E275	R:R:S286	10.06	Yes	No	2	2	4
219	R:R:S277	R:R:T278	3.2	No	No	0	4	4
220	R:R:H280	R:R:T278	2.74	No	No	0	1	4
221	R:R:F284	R:R:R283	6.41	No	No	0	1	3
222	R:R:F287	R:R:W291	23.05	No	No	0	5	4
223	R:R:I294	R:R:W291	5.87	Yes	No	0	7	4
224	R:R:L292	R:R:S295	3	No	No	0	6	6
225	R:R:C301	R:R:V302	3.42	No	No	0	9	6
226	R:R:S307	R:R:Y304	6.36	No	Yes	0	7	9
227	R:R:N308	R:R:Y304	8.14	No	Yes	3	8	9
228	R:R:F311	R:R:Y304	20.63	Yes	Yes	3	9	9
229	R:R:N308	R:R:V310	10.35	No	No	0	8	6
230	R:R:F311	R:R:N308	6.04	Yes	No	3	9	8
231	R:R:L315	R:R:Q312	6.65	No	No	0	6	9
232	R:R:K316	R:R:R313	3.71	No	No	0	5	4
233	R:R:L315	R:R:L318	2.77	No	Yes	9	6	6
234	R:R:L315	R:R:S319	3	No	No	9	6	4
235	R:R:L318	R:R:S319	4.5	Yes	No	9	6	4
236	R:R:I50	R:R:Y73	2.42	No	No	0	7	6
237	R:R:I214	R:R:Y211	2.42	No	Yes	0	9	9
238	R:R:I270	R:R:Y271	2.42	No	Yes	0	7	5
239	R:R:N213	R:R:R216	2.41	No	No	0	5	3
240	R:R:L274	R:R:Y271	2.34	No	Yes	0	4	5
241	R:R:L112	R:R:W154	2.28	Yes	No	0	6	9
242	R:R:F161	R:R:Y200	2.06	Yes	Yes	1	6	5
243	R:R:A56	R:R:P57	1.87	No	No	0	5	6
244	R:R:A201	R:R:P202	1.87	No	No	0	4	9
245	R:R:G45	R:R:S44	1.86	No	No	0	8	4
246	R:R:G279	R:R:T278	1.82	No	No	0	1	4
247	R:R:G45	R:R:I48	1.76	No	No	0	8	7
248	R:R:P143	R:R:T142	1.75	No	No	0	3	8
249	R:R:C102	R:R:S88	1.72	No	No	0	9	5
250	R:R:C28	R:R:V32	1.71	No	No	0	4	4
251	R:R:C299	R:R:V260	1.71	No	No	0	5	6
252	R:R:A74	R:R:V115	1.7	No	No	0	8	7
253	R:R:C218	R:R:T222	1.69	No	No	0	8	5
254	R:R:K133	R:R:P134	1.67	No	No	0	5	8
255	R:R:S116	R:R:S119	1.63	No	No	0	9	8
256	R:R:S276	R:R:S277	1.63	No	No	0	3	4
257	R:R:A121	R:R:I206	1.62	No	No	0	7	8
258	R:R:S259	R:R:V260	1.62	No	No	0	4	6
259	R:R:T158	R:R:V111	1.59	No	No	0	3	5
260	R:R:G172	R:R:H174	1.59	No	Yes	0	1	4
261	R:R:A285	R:R:N282	1.56	No	No	0	4	4
262	R:R:I153	R:R:S157	1.55	No	No	0	6	8
263	R:R:A182	R:R:Q179	1.52	No	No	0	3	4
264	R:R:M197	R:R:V196	1.52	No	Yes	0	4	5
265	R:R:L100	R:R:S99	1.5	No	No	0	1	3
266	R:R:G314	R:R:R313	1.5	No	No	0	7	4
267	R:R:L76	R:R:V80	1.49	No	No	0	6	4
268	R:R:L193	R:R:V196	1.49	No	Yes	0	4	5
269	R:R:I131	R:R:I214	1.47	No	No	0	9	9
270	R:R:E97	R:R:S99	1.44	No	No	0	5	3
271	R:R:Q312	R:R:S305	1.44	No	No	0	9	7
272	R:R:I34	R:R:L288	1.43	No	No	0	5	4
273	R:R:Q179	R:R:V177	1.43	No	No	0	4	2
274	R:R:I269	R:R:L266	1.43	Yes	No	0	7	6
275	R:R:H62	R:R:S65	1.39	No	No	0	7	9
276	R:R:I217	R:R:Q220	1.37	No	No	0	6	4
277	R:R:E31	R:R:L30	1.33	No	No	0	4	5
278	R:R:R283	R:R:S281	1.32	No	No	0	3	3
279	R:R:E275	R:R:N282	1.31	Yes	No	0	2	4
280	R:R:T210	R:R:Y128	1.25	No	No	0	6	8
281	R:R:I150	R:R:R147	1.25	No	No	0	8	1
282	R:R:H221	R:R:Q220	1.24	No	No	0	7	4
283	R:R:T142	R:R:W144	1.21	No	No	0	8	4
284	R:R:L159	R:R:Y156	1.17	No	No	0	3	4
285	R:R:N138	R:R:Y137	1.16	No	Yes	0	4	7
286	R:R:F194	R:R:Y190	1.03	No	No	0	6	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I35	6.592	5	6	6
2	R:R:T39	4.465	4	7	6
3	R:R:I43	3.145	4	7	6
4	R:R:N46	7.528	5	8	9
5	R:R:F53	7.55833	6	3	7
6	R:R:Q103	7.754	5	2	5
7	R:R:F105	6.5275	4	0	5
8	R:R:L112	4.26	4	0	6
9	R:R:M117	5.885	4	1	7
10	R:R:D126	5.435	4	4	9
11	R:R:Y137	6.14286	7	4	7
12	R:R:V160	5.718	5	1	5
13	R:R:F161	6.35286	7	1	6
14	R:R:K170	10.51	5	2	4
15	R:R:P171	6.92	4	1	3
16	R:R:Y173	5.585	6	2	1
17	R:R:H174	5.858	5	12	4
18	R:R:F178	11.815	4	2	4
19	R:R:W180	8.2575	4	2	3
20	R:R:W185	8.53	4	2	7
21	R:R:V196	3.075	4	0	5
22	R:R:Y200	7.072	5	1	5
23	R:R:Y211	4.86286	7	5	9
24	R:R:F255	5.33	5	5	5
25	R:R:Y268	5.295	4	12	6
26	R:R:I269	6.685	4	1	7
27	R:R:Y271	2.8225	4	0	5
28	R:R:E275	5.9625	4	2	2
29	R:R:I294	3.935	4	0	7
30	R:R:Y304	9.555	4	3	9
31	R:R:F311	9.76833	6	3	9
32	R:R:L318	3.545	4	9	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C28	R:R:V25	10.7052	10.25	No	No	0	4	3
2	R:R:C28	R:R:V32	12.187	1.71	No	No	0	4	4
3	R:R:I35	R:R:V32	13.3845	6.14	Yes	No	6	6	4
4	R:R:I35	R:R:W291	27.2227	11.74	Yes	No	0	6	4
5	R:R:I294	R:R:W291	34.1055	5.87	Yes	No	0	7	4
6	R:R:H174	R:R:I294	89.8875	2.65	Yes	Yes	0	4	7
7	R:R:H174	R:R:Y268	93.093	4.36	Yes	Yes	12	4	6
8	R:R:F272	R:R:Y268	94.9196	10.32	No	Yes	0	5	6
9	R:R:F272	R:R:Y173	91.0729	6.19	No	Yes	0	5	1
10	R:R:E275	R:R:Y173	13.8744	6.73	Yes	Yes	2	2	1
11	R:R:I35	R:R:S86	10.6629	6.19	Yes	No	0	6	7
12	R:R:I294	R:R:I42	67.7876	2.94	Yes	No	0	7	8
13	R:R:D75	R:R:I42	64.0861	2.8	No	No	0	9	8
14	R:R:D75	R:R:N46	61.183	14.81	No	Yes	0	9	9
15	R:R:N46	R:R:V49	55.0502	2.96	Yes	No	0	9	9
16	R:R:F311	R:R:V49	48.4819	2.62	Yes	No	0	9	9
17	R:R:F311	R:R:V52	13.6023	15.73	Yes	No	0	9	8
18	R:R:L318	R:R:V52	12.1386	4.47	Yes	No	0	6	8
19	R:R:F311	R:R:F53	25.5111	7.5	Yes	Yes	3	9	7
20	R:R:F53	R:R:I68	16.6263	8.79	Yes	No	0	7	8
21	R:R:I68	R:R:T64	15.1748	3.04	No	No	0	8	8
22	R:R:D126	R:R:T64	13.7111	2.89	Yes	No	0	9	8
23	R:R:I153	R:R:S157	11.0439	1.55	No	No	0	6	8
24	R:R:S114	R:R:S157	34.0269	3.26	No	No	0	6	8
25	R:R:F161	R:R:S114	34.5954	6.61	Yes	No	1	6	6
26	R:R:F161	R:R:P171	91.2846	10.11	Yes	Yes	1	6	3
27	R:R:P171	R:R:S164	96.3288	3.56	Yes	No	0	3	5
28	R:R:K170	R:R:S164	97.0001	3.06	Yes	No	0	4	5
29	R:R:K170	R:R:W185	100	18.57	Yes	Yes	2	4	7
30	R:R:W185	R:R:Y173	92.9721	3.86	Yes	Yes	2	7	1
31	R:R:S157	R:R:V115	22.8983	4.85	No	No	0	8	7
32	R:R:V115	R:R:W154	19.9952	8.58	No	No	0	7	9
33	R:R:I150	R:R:W154	11.0439	3.52	No	No	0	8	9
34	R:R:F161	R:R:Y200	75.6441	2.06	Yes	Yes	1	6	5
35	R:R:M117	R:R:Y200	62.3685	4.79	Yes	Yes	1	7	5
36	R:R:F261	R:R:M117	62.8281	6.22	No	Yes	0	9	7
37	R:R:F261	R:R:N296	59.5077	15.71	No	No	0	9	9
38	R:R:N296	R:R:V260	57.2336	4.43	No	No	0	9	6
39	R:R:S259	R:R:V260	54.9111	1.62	No	No	0	4	6
40	R:R:F255	R:R:S259	53.7317	2.64	Yes	No	0	5	4
41	R:R:F255	R:R:Y211	48.5243	6.19	Yes	Yes	5	5	9
42	R:R:T258	R:R:Y211	12.7676	9.99	No	Yes	0	7	9
43	R:R:L120	R:R:T258	11.2133	4.42	No	No	0	8	7
44	R:R:K170	R:R:Q103	17.2493	23.05	Yes	Yes	2	4	5
45	R:R:C102	R:R:F178	21.0717	12.57	No	Yes	0	9	4
46	R:R:C102	R:R:S88	12.6769	1.72	No	No	0	9	5
47	R:R:K170	R:R:W180	11.0258	4.64	Yes	Yes	2	4	3
48	R:R:T210	R:R:Y211	24.7671	6.24	No	Yes	0	6	9
49	R:R:T210	R:R:Y128	17.3582	1.25	No	No	0	6	8
50	R:R:I214	R:R:Y211	12.7676	2.42	No	Yes	0	9	9
51	R:R:I131	R:R:I214	11.2133	1.47	No	No	0	9	9
52	R:R:F191	R:R:P171	11.31	8.67	No	Yes	0	5	3
53	R:R:D188	R:R:F191	12.3322	3.58	No	No	0	3	5
54	R:R:I269	R:R:Y200	12.2656	4.84	Yes	Yes	1	7	5
55	R:R:I269	R:R:L266	11.1709	1.43	Yes	No	0	7	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8HJ2_nogp

PDB Summary
PDB	8HJ2_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.44
Number of Linked Nodes	259
Number of Links	286
Number of Hubs	32
Number of Links mediated by Hubs	129
Number of Communities	13
Number of Nodes involved in Communities	60
Number of Links involved in Communities	75

Path Summary
Number Of Nodes in MetaPath	56
Number Of Links MetaPath	55
Number of Shortest Paths	33785
Length Of Smallest Path	3
Average Path Length	15.0096
Length of Longest Path	35
Minimum Path Strength	1.305
Average Path Strength	6.13576
Maximum Path Strength	20.81
Minimum Path Correlation	0.7
Average Path Correlation	0.943073
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	54.1579
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.5555
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • cellular response to nitrogen compound • response to peptide hormone • insulin receptor signaling pathway • cell surface receptor protein tyrosine kinase signaling pathway • cellular response to endogenous stimulus • response to hormone • enzyme-linked receptor protein signaling pathway • cellular response to hormone stimulus • cell surface receptor signaling pathway • response to endogenous stimulus • response to oxygen-containing compound • cellular response to peptide hormone stimulus • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • response to insulin • cellular response to insulin stimulus • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • developmental process • regulation of multicellular organism growth • multicellular organismal process • regulation of growth • regulation of developmental growth • regulation of developmental process • developmental growth • growth • positive regulation of biological process • positive regulation of multicellular organism growth • positive regulation of developmental process • multicellular organism growth • positive regulation of growth • positive regulation of multicellular organismal process • regulation of multicellular organismal process • positive regulation of developmental growth • negative regulation of signaling • negative regulation of biological process • regulation of signal transduction • regulation of cellular response to insulin stimulus • negative regulation of cell communication • negative regulation of cellular process • regulation of signaling • negative regulation of response to stimulus • regulation of insulin receptor signaling pathway • negative regulation of signal transduction • negative regulation of cellular response to insulin stimulus • regulation of response to stimulus • negative regulation of insulin receptor signaling pathway • regulation of cell communication • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • response to glucagon • cellular response to glucagon stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • metabolic process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99679
Sequence	>8HJ2_nogp_Chain_R V N F C L L E V L I I V F L T V L I I S G N I I V I F V F H C A P L L N H H T T S Y F I Q T M A Y A D L F V G V S C V V P S L S L L H H P L P V E E S L T C Q I F G F V V S V L K S V S M A S L A C I S I D R Y I A I T K P L T Y N T L V T P W R L R L C I F L I W L Y S T L V F L P S F F H W G K P G Y H G D V F Q W C A E S W H T D S Y F T L F I V M M L Y A P A A L I V C F T Y F N I F R I C Q Q H T K D I S E R Q A R F S M V L F R I T S V F Y I L W L P Y I I Y F L L E S S T G H S N R F A S F L T T W L A I S N S F C N C V I Y S L S N S V F Q R G L K R L S G A M C T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HJ1	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	Gs/β1/γ2	3.27	2023-12-27	10.1038/s41467-023-35882-w
	8HJ1 (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		3.27	2023-12-27	10.1038/s41467-023-35882-w
	8HJ2	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	chim(Gs-CtG15)/β1/γ2	3.8	2023-03-15	10.1038/s41467-023-35882-w
	8HJ2 (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		3.8	2023-03-15	10.1038/s41467-023-35882-w
	8HJ0	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	chim(Gs-CtG15)/β1/γ2	3.12	2023-03-15	10.1038/s41467-023-35882-w
	8HJ0 (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		3.12	2023-03-15	10.1038/s41467-023-35882-w
	8HIX	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	Gs/β1/γ2	3.12	2023-03-15	10.1038/s41467-023-35882-w
	8HIX (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		3.12	2023-03-15	10.1038/s41467-023-35882-w
	8HMV	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	Gs/β1/γ2	2.91	2023-03-01	10.1002/mco2.205
	8HMV (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		2.91	2023-03-01	10.1002/mco2.205

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8HJ2_nogp.zip

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