psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F27	R:R:N26	3.62	No	No	0	1	1
2	R:R:E31	R:R:F287	19.82	No	No	0	4	5
3	R:R:L89	R:R:V32	7.45	Yes	No	0	4	4
4	R:R:F287	R:R:I34	3.77	No	No	0	5	5
5	R:R:I35	R:R:L38	4.28	No	No	0	6	7
6	R:R:I35	R:R:W291	15.27	No	No	0	6	4
7	R:R:F37	R:R:L41	7.31	No	No	0	4	4
8	R:R:L38	R:R:S295	6.01	No	No	0	7	6
9	R:R:T39	R:R:V40	3.17	No	No	0	6	5
10	R:R:I42	R:R:S297	10.84	No	No	0	8	9
11	R:R:F298	R:R:I42	5.02	No	No	0	6	8
12	R:R:G79	R:R:I43	3.53	No	No	0	7	6
13	R:R:G45	R:R:S44	3.71	No	No	0	8	4
14	R:R:G45	R:R:I48	5.29	No	No	0	8	7
15	R:R:G45	R:R:P301	4.06	No	No	0	8	9
16	R:R:D75	R:R:N46	5.39	No	No	0	9	9
17	R:R:N46	R:R:P301	3.26	No	No	0	9	9
18	R:R:F51	R:R:I47	5.02	No	No	0	4	5
19	R:R:I47	R:R:L76	5.71	No	No	0	5	6
20	R:R:F53	R:R:V49	3.93	Yes	Yes	0	7	9
21	R:R:A72	R:R:V49	3.39	No	Yes	0	9	9
22	R:R:P301	R:R:V49	3.53	No	Yes	0	9	9
23	R:R:F311	R:R:V49	3.93	Yes	Yes	0	9	9
24	R:R:H54	R:R:I50	5.3	No	No	0	3	7
25	R:R:A72	R:R:I50	3.25	No	No	0	9	7
26	R:R:I50	R:R:Y73	6.04	No	No	0	7	6
27	R:R:F311	R:R:V52	6.55	Yes	No	0	9	8
28	R:R:L318	R:R:V52	4.47	No	No	0	6	8
29	R:R:F53	R:R:L59	6.09	Yes	No	0	7	9
30	R:R:F53	R:R:S65	13.21	Yes	No	0	7	9
31	R:R:F53	R:R:I68	5.02	Yes	No	1	7	8
32	R:R:F53	R:R:Q69	10.54	Yes	No	0	7	6
33	R:R:F53	R:R:Y304	5.16	Yes	Yes	1	7	9
34	R:R:C55	R:R:R317	4.18	No	No	0	5	4
35	R:R:C55	R:R:L318	3.17	No	No	0	5	6
36	R:R:L59	R:R:T310	10.32	No	No	0	9	6
37	R:R:N60	R:R:Y66	9.3	No	Yes	0	5	4
38	R:R:D126	R:R:T63	7.23	Yes	No	1	9	5
39	R:R:T63	R:R:Y137	7.49	No	Yes	1	5	7
40	R:R:T63	R:R:V141	3.17	No	No	1	5	6
41	R:R:D126	R:R:T64	4.34	Yes	Yes	1	9	8
42	R:R:R127	R:R:T64	9.06	Yes	Yes	1	9	8
43	R:R:L254	R:R:T64	5.9	No	Yes	1	8	8
44	R:R:Q69	R:R:Y66	3.38	No	Yes	0	6	4
45	R:R:L146	R:R:Y66	10.55	No	Yes	0	7	4
46	R:R:C122	R:R:F67	6.98	No	Yes	4	7	8
47	R:R:F67	R:R:I123	5.02	Yes	No	0	8	9
48	R:R:C149	R:R:F67	5.59	No	Yes	4	6	8
49	R:R:F67	R:R:I150	5.02	Yes	No	0	8	8
50	R:R:I68	R:R:Y304	4.84	No	Yes	1	8	9
51	R:R:I150	R:R:T70	9.12	No	No	0	8	9
52	R:R:T70	R:R:W154	3.64	No	No	0	9	9
53	R:R:M71	R:R:S119	4.6	No	No	0	9	8
54	R:R:L120	R:R:M71	4.24	No	No	0	8	9
55	R:R:M71	R:R:N300	5.61	No	No	0	9	9
56	R:R:D75	R:R:S297	10.31	No	No	0	9	9
57	R:R:F77	R:R:L112	3.65	No	No	0	7	6
58	R:R:G79	R:R:V78	3.68	No	Yes	0	7	8
59	R:R:L112	R:R:V78	5.96	No	Yes	0	6	8
60	R:R:K113	R:R:V78	6.07	No	Yes	0	6	8
61	R:R:S297	R:R:V78	4.85	No	Yes	0	9	8
62	R:R:S81	R:R:V108	4.85	No	No	0	5	4
63	R:R:P85	R:R:V84	3.53	No	No	0	3	8
64	R:R:F105	R:R:P85	5.78	No	No	0	5	3
65	R:R:P85	R:R:V177	3.53	No	No	0	3	2
66	R:R:L89	R:R:S88	4.5	Yes	No	0	4	5
67	R:R:L89	R:R:V177	4.47	Yes	No	0	4	2
68	R:R:H91	R:R:H92	11.94	No	No	0	4	4
69	R:R:H91	R:R:L94	7.71	No	No	0	4	4
70	R:R:L94	R:R:V96	4.47	No	No	0	4	3
71	R:R:E97	R:R:V96	4.28	No	No	0	5	3
72	R:R:E97	R:R:T101	14.11	No	No	0	5	5
73	R:R:L100	R:R:Q103	7.99	No	Yes	0	1	5
74	R:R:C102	R:R:C181	7.28	No	No	0	9	9
75	R:R:Q103	R:R:W185	16.43	Yes	No	0	5	7
76	R:R:F165	R:R:I104	5.02	No	No	0	5	4
77	R:R:F105	R:R:V109	3.93	No	No	0	5	6
78	R:R:F107	R:R:V111	3.93	Yes	No	0	6	5
79	R:R:F107	R:R:S164	5.28	Yes	No	0	6	5
80	R:R:F107	R:R:F165	12.86	Yes	No	0	6	5
81	R:R:H174	R:R:V109	9.69	Yes	No	0	4	6
82	R:R:F161	R:R:S110	9.25	Yes	No	0	6	4
83	R:R:H174	R:R:S110	4.18	Yes	No	0	4	4
84	R:R:F161	R:R:V111	3.93	Yes	No	0	6	5
85	R:R:I294	R:R:K113	4.36	No	No	0	7	6
86	R:R:K113	R:R:N296	5.6	No	No	0	6	9
87	R:R:S114	R:R:S157	6.52	No	No	0	6	8
88	R:R:L199	R:R:S114	6.01	Yes	No	0	7	6
89	R:R:I153	R:R:V115	4.61	No	No	0	6	7
90	R:R:V115	R:R:W154	14.71	No	No	0	7	9
91	R:R:S157	R:R:V115	3.23	No	No	0	8	7
92	R:R:F261	R:R:S116	6.61	Yes	No	0	9	9
93	R:R:M117	R:R:Y200	4.79	No	Yes	2	7	5
94	R:R:F261	R:R:M117	3.73	Yes	No	0	9	7
95	R:R:M117	R:R:W265	6.98	No	Yes	2	7	8
96	R:R:I153	R:R:W118	7.05	No	Yes	0	6	4
97	R:R:W118	R:R:Y156	4.82	Yes	Yes	3	4	4
98	R:R:L199	R:R:W118	4.56	Yes	Yes	3	7	4
99	R:R:A203	R:R:W118	6.48	No	Yes	0	6	4
100	R:R:L120	R:R:T258	10.32	No	No	0	8	7
101	R:R:F261	R:R:L120	4.87	Yes	No	0	9	8
102	R:R:A121	R:R:I206	3.25	No	No	0	7	8
103	R:R:C122	R:R:C149	5.46	No	No	4	7	6
104	R:R:I123	R:R:L254	5.71	No	No	0	9	8
105	R:R:S124	R:R:T210	6.4	No	No	0	8	6
106	R:R:S124	R:R:Y211	8.9	No	Yes	0	8	9
107	R:R:D126	R:R:R127	13.1	Yes	Yes	1	9	9
108	R:R:D126	R:R:Y137	5.75	Yes	Yes	1	9	7
109	R:R:R127	R:R:Y137	3.09	Yes	Yes	1	9	7
110	R:R:L254	R:R:R127	3.64	No	Yes	1	8	9
111	R:R:T132	R:R:Y128	12.48	No	Yes	0	6	8
112	R:R:F209	R:R:Y128	7.22	No	Yes	7	4	8
113	R:R:T210	R:R:Y128	3.75	No	Yes	0	6	8
114	R:R:N213	R:R:Y128	4.65	Yes	Yes	7	5	8
115	R:R:I129	R:R:Y137	3.63	No	Yes	0	5	7
116	R:R:A130	R:R:Y137	8.01	No	Yes	0	8	7
117	R:R:I131	R:R:I217	5.89	No	No	0	9	6
118	R:R:K133	R:R:T136	4.5	No	No	0	5	4
119	R:R:T136	R:R:T139	3.14	No	No	0	4	4
120	R:R:V141	R:R:Y137	8.83	No	Yes	1	6	7
121	R:R:R145	R:R:T142	5.17	No	No	0	5	8
122	R:R:L148	R:R:L152	5.54	No	No	0	2	3
123	R:R:C149	R:R:I153	3.27	No	No	0	6	6
124	R:R:F151	R:R:L152	3.65	No	No	0	4	3
125	R:R:F151	R:R:L155	6.09	No	No	0	4	3
126	R:R:L155	R:R:L159	4.15	No	No	0	3	3
127	R:R:V160	R:R:Y156	5.05	No	Yes	3	5	4
128	R:R:M198	R:R:Y156	3.59	No	Yes	0	6	4
129	R:R:L199	R:R:Y156	4.69	Yes	Yes	3	7	4
130	R:R:L199	R:R:V160	7.45	Yes	No	3	7	5
131	R:R:F161	R:R:I195	10.05	Yes	No	2	6	6
132	R:R:F161	R:R:Y200	9.28	Yes	Yes	2	6	5
133	R:R:P163	R:R:W168	4.05	No	Yes	2	5	5
134	R:R:F191	R:R:P163	7.22	Yes	No	2	5	5
135	R:R:P171	R:R:S164	7.13	No	No	0	3	5
136	R:R:D188	R:R:W168	6.7	Yes	Yes	2	3	5
137	R:R:F191	R:R:W168	8.02	Yes	Yes	2	5	5
138	R:R:F194	R:R:W168	7.02	No	Yes	0	6	5
139	R:R:K170	R:R:P171	3.35	No	No	5	4	3
140	R:R:K170	R:R:W185	18.57	No	No	5	4	7
141	R:R:K170	R:R:T187	4.5	No	No	0	4	5
142	R:R:P171	R:R:W185	4.05	No	No	5	3	7
143	R:R:F272	R:R:G172	4.52	No	No	0	5	1
144	R:R:T187	R:R:Y173	4.99	No	No	0	5	1
145	R:R:F272	R:R:Y173	5.16	No	No	0	5	1
146	R:R:E275	R:R:Y173	8.98	Yes	No	0	2	1
147	R:R:H174	R:R:Y268	11.98	Yes	No	0	4	6
148	R:R:H174	R:R:I294	5.3	Yes	No	0	4	7
149	R:R:A182	R:R:D176	3.09	No	No	0	3	4
150	R:R:D176	R:R:S286	5.89	No	No	0	4	4
151	R:R:C181	R:R:F178	8.38	No	No	0	9	4
152	R:R:S184	R:R:W180	22.24	No	No	0	3	3
153	R:R:A182	R:R:E183	4.53	No	No	0	3	5
154	R:R:S276	R:R:T187	6.4	No	No	0	3	5
155	R:R:D188	R:R:Y190	11.49	Yes	No	0	3	7
156	R:R:D188	R:R:F191	3.58	Yes	Yes	2	3	5
157	R:R:S189	R:R:Y190	5.09	No	No	0	4	7
158	R:R:F191	R:R:I195	6.28	Yes	No	2	5	6
159	R:R:F272	R:R:T192	11.67	No	No	0	5	4
160	R:R:S276	R:R:T192	9.59	No	No	0	3	4
161	R:R:I195	R:R:Y200	7.25	No	Yes	2	6	5
162	R:R:M197	R:R:V196	4.56	No	No	0	4	5
163	R:R:V196	R:R:Y200	6.31	No	Yes	0	5	5
164	R:R:W265	R:R:Y200	8.68	Yes	Yes	2	8	5
165	R:R:I269	R:R:Y200	3.63	No	Yes	2	7	5
166	R:R:A204	R:R:Y262	4	No	No	0	3	6
167	R:R:V207	R:R:Y211	3.79	No	Yes	6	5	9
168	R:R:T258	R:R:V207	3.17	No	No	6	7	5
169	R:R:V207	R:R:Y262	12.62	No	No	0	5	6
170	R:R:F209	R:R:N213	9.67	No	Yes	7	4	5
171	R:R:F255	R:R:Y211	4.13	No	Yes	0	5	9
172	R:R:T258	R:R:Y211	11.24	No	Yes	6	7	9
173	R:R:F212	R:R:N213	3.62	No	Yes	0	3	5
174	R:R:N213	R:R:R216	4.82	Yes	No	0	5	3
175	R:R:F215	R:R:Q219	14.05	No	No	0	6	5
176	R:R:I217	R:R:R216	6.26	No	No	0	6	3
177	R:R:D224	R:R:Q220	9.14	No	No	0	4	4
178	R:R:H221	R:R:I225	10.61	No	No	0	7	6
179	R:R:E227	R:R:R228	9.3	No	No	8	3	3
180	R:R:E227	R:R:R231	5.82	No	No	8	3	6
181	R:R:R228	R:R:R231	13.86	No	No	8	3	6
182	R:R:F232	R:R:R231	6.41	No	No	0	4	6
183	R:R:F255	R:R:M252	3.73	No	No	0	5	7
184	R:R:V253	R:R:Y304	3.79	No	Yes	0	8	9
185	R:R:S307	R:R:V253	9.7	No	No	0	7	8
186	R:R:F255	R:R:S259	7.93	No	No	0	5	4
187	R:R:I303	R:R:R256	5.01	No	No	0	8	6
188	R:R:I257	R:R:N300	5.66	No	No	0	8	9
189	R:R:C299	R:R:V260	3.42	No	No	0	5	6
190	R:R:I303	R:R:V260	4.61	No	No	0	8	6
191	R:R:F261	R:R:N296	15.71	Yes	No	0	9	9
192	R:R:W265	R:R:Y262	4.82	Yes	No	0	8	6
193	R:R:L264	R:R:L292	4.15	No	No	0	8	6
194	R:R:L264	R:R:N296	5.49	No	No	0	8	9
195	R:R:I269	R:R:W265	11.74	No	Yes	2	7	8
196	R:R:A293	R:R:Y268	4	No	No	0	7	6
197	R:R:E275	R:R:Y271	3.37	Yes	No	0	2	5
198	R:R:E275	R:R:S281	5.75	Yes	No	0	2	3
199	R:R:E275	R:R:S286	5.75	Yes	No	0	2	4
200	R:R:F284	R:R:N282	3.62	No	No	0	1	4
201	R:R:A285	R:R:N282	4.69	No	No	0	4	4
202	R:R:F284	R:R:R283	5.34	No	No	0	1	3
203	R:R:F287	R:R:W291	9.02	No	No	0	5	4
204	R:R:I294	R:R:W291	7.05	No	No	0	7	4
205	R:R:D308	R:R:Y304	12.64	No	Yes	1	8	9
206	R:R:F311	R:R:Y304	20.63	Yes	Yes	1	9	9
207	R:R:D308	R:R:F311	3.58	No	Yes	1	8	9
208	R:R:K316	R:R:R313	3.71	No	No	0	5	4
209	R:R:C102	R:R:Q103	3.05	No	Yes	0	9	5
210	R:R:I68	R:R:T64	3.04	No	Yes	1	8	8
211	R:R:F105	R:R:G175	3.01	No	No	0	5	3
212	R:R:L100	R:R:S99	3	No	No	0	1	3
213	R:R:L87	R:R:V84	2.98	No	No	0	5	8
214	R:R:L112	R:R:V108	2.98	No	No	0	6	4
215	R:R:L159	R:R:V160	2.98	No	No	0	3	5
216	R:R:L140	R:R:T136	2.95	No	No	0	4	4
217	R:R:I125	R:R:I206	2.94	No	No	0	6	8
218	R:R:I257	R:R:I303	2.94	No	No	0	8	8
219	R:R:I129	R:R:L140	2.85	No	No	0	5	4
220	R:R:I206	R:R:L205	2.85	No	No	0	8	6
221	R:R:I269	R:R:L273	2.85	No	No	0	7	6
222	R:R:L318	R:R:M322	2.83	No	No	0	6	3
223	R:R:C28	R:R:F27	2.79	Yes	No	0	4	1
224	R:R:A305	R:R:F311	2.77	No	Yes	0	7	9
225	R:R:L76	R:R:N46	2.75	No	No	0	6	9
226	R:R:E227	R:R:K223	2.7	No	No	0	3	4
227	R:R:A285	R:R:Y271	2.67	No	No	0	4	5
228	R:R:A74	R:R:W154	2.59	No	No	0	8	9
229	R:R:H91	R:R:L87	2.57	No	No	0	4	5
230	R:R:T290	R:R:Y268	2.5	No	No	0	5	6
231	R:R:F107	R:R:L162	2.44	Yes	No	0	6	4
232	R:R:I270	R:R:Y271	2.42	No	No	0	7	5
233	R:R:L100	R:R:W180	2.28	No	No	0	1	3
234	R:R:L266	R:R:W265	2.28	No	Yes	0	6	8
235	R:R:H61	R:R:Y66	2.18	No	Yes	0	8	4
236	R:R:R145	R:R:W144	2	No	No	0	5	4
237	R:R:C82	R:R:G79	1.96	No	No	0	7	7
238	R:R:A56	R:R:G314	1.95	No	No	0	5	7
239	R:R:A56	R:R:P57	1.87	No	No	0	5	6
240	R:R:A201	R:R:P202	1.87	No	No	0	4	9
241	R:R:G314	R:R:V52	1.84	No	No	0	7	8
242	R:R:G279	R:R:T278	1.82	No	No	0	1	4
243	R:R:A121	R:R:A203	1.79	No	No	0	7	6
244	R:R:P143	R:R:T142	1.75	No	No	0	3	8
245	R:R:P267	R:R:T289	1.75	No	No	0	9	5
246	R:R:C28	R:R:V25	1.71	Yes	No	0	4	3
247	R:R:C82	R:R:T39	1.69	No	No	0	7	6
248	R:R:C218	R:R:T222	1.69	No	No	0	8	5
249	R:R:D188	R:R:G169	1.68	Yes	No	0	3	5
250	R:R:K133	R:R:P134	1.67	No	No	0	5	8
251	R:R:L94	R:R:P95	1.64	No	No	0	4	7
252	R:R:L266	R:R:P267	1.64	No	No	0	6	9
253	R:R:S86	R:R:V36	1.62	No	No	0	7	4
254	R:R:S81	R:R:V80	1.62	No	No	0	5	4
255	R:R:V32	R:R:V36	1.6	No	No	0	4	4
256	R:R:V83	R:R:V84	1.6	No	No	0	7	8
257	R:R:S277	R:R:T278	1.6	No	No	0	4	4
258	R:R:S309	R:R:T310	1.6	No	No	0	4	6
259	R:R:C28	R:R:L29	1.59	Yes	No	0	4	4
260	R:R:C28	R:R:L89	1.59	Yes	Yes	0	4	4
261	R:R:G106	R:R:H174	1.59	No	Yes	0	4	4
262	R:R:T158	R:R:V111	1.59	No	No	0	3	5
263	R:R:A305	R:R:L315	1.58	No	No	0	7	6
264	R:R:H92	R:R:P93	1.53	No	No	0	4	4
265	R:R:L90	R:R:V36	1.49	No	No	0	5	4
266	R:R:I131	R:R:I214	1.47	No	No	0	9	9
267	R:R:P143	R:R:R147	1.44	No	No	0	3	1
268	R:R:F166	R:R:P163	1.44	No	No	0	3	5
269	R:R:Q312	R:R:S309	1.44	No	No	0	9	4
270	R:R:I270	R:R:L274	1.43	No	No	0	7	4
271	R:R:L30	R:R:L33	1.38	No	No	0	5	5
272	R:R:I217	R:R:Q220	1.37	No	No	0	6	4
273	R:R:H280	R:R:T278	1.37	No	No	0	1	4
274	R:R:P202	R:R:W118	1.35	No	Yes	0	9	4
275	R:R:E183	R:R:Q179	1.27	No	No	0	5	4
276	R:R:H167	R:R:Q103	1.24	No	Yes	0	4	5
277	R:R:F298	R:R:L41	1.22	No	No	0	6	4
278	R:R:F194	R:R:L193	1.22	No	No	0	6	4
279	R:R:L146	R:R:R147	1.21	No	No	0	7	1
280	R:R:L306	R:R:R256	1.21	No	No	0	5	6
281	R:R:R313	R:R:R317	1.07	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:C28	1.92	4	0	4
2	R:R:V49	3.695	4	0	9
3	R:R:F53	7.325	6	1	7
4	R:R:T64	5.585	4	1	8
5	R:R:Y66	6.3525	4	0	4
6	R:R:F67	5.6525	4	4	8
7	R:R:V78	5.14	4	0	8
8	R:R:L89	4.5025	4	0	4
9	R:R:Q103	7.1775	4	0	5
10	R:R:F107	6.1275	4	0	6
11	R:R:W118	4.852	5	3	4
12	R:R:D126	7.605	4	1	9
13	R:R:R127	7.2225	4	1	9
14	R:R:Y128	7.025	4	7	8
15	R:R:Y137	6.13333	6	1	7
16	R:R:Y156	4.5375	4	3	4
17	R:R:F161	8.1275	4	2	6
18	R:R:W168	6.4475	4	2	5
19	R:R:H174	6.548	5	0	4
20	R:R:D188	5.8625	4	2	3
21	R:R:F191	6.275	4	2	5
22	R:R:L199	5.6775	4	3	7
23	R:R:Y200	6.65667	6	2	5
24	R:R:Y211	7.015	4	6	9
25	R:R:N213	5.69	4	7	5
26	R:R:F261	7.73	4	0	9
27	R:R:W265	6.9	5	2	8
28	R:R:E275	5.9625	4	0	2
29	R:R:Y304	9.412	5	1	9
30	R:R:F311	7.492	5	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H174	R:R:I294	65.0653	5.3	Yes	No	0	4	7
2	R:R:H174	R:R:V109	35.7328	9.69	Yes	No	0	4	6
3	R:R:F105	R:R:V109	34.5564	3.93	No	No	0	5	6
4	R:R:F105	R:R:P85	32.1725	5.78	No	No	0	5	3
5	R:R:P85	R:R:V177	16.8481	3.53	No	No	0	3	2
6	R:R:L89	R:R:V177	15.5006	4.47	Yes	No	0	4	2
7	R:R:I294	R:R:K113	68.1748	4.36	No	No	0	7	6
8	R:R:K113	R:R:V78	100	6.07	No	Yes	0	6	8
9	R:R:S297	R:R:V78	97.984	4.85	No	Yes	0	9	8
10	R:R:D75	R:R:S297	96.6366	10.31	No	No	0	9	9
11	R:R:D75	R:R:N46	96.336	5.39	No	No	0	9	9
12	R:R:N46	R:R:P301	95.0301	3.26	No	No	0	9	9
13	R:R:P301	R:R:V49	93.5583	3.53	No	Yes	0	9	9
14	R:R:F53	R:R:V49	76.5288	3.93	Yes	Yes	0	7	9
15	R:R:F311	R:R:V49	17.1072	3.93	Yes	Yes	0	9	9
16	R:R:F311	R:R:V52	14.6092	6.55	Yes	No	0	9	8
17	R:R:F53	R:R:I68	62.5881	5.02	Yes	No	1	7	8
18	R:R:F53	R:R:Q69	14.4538	10.54	Yes	No	0	7	6
19	R:R:Q69	R:R:Y66	13.0545	3.38	No	Yes	0	6	4
20	R:R:D126	R:R:T64	13.8733	4.34	Yes	Yes	1	9	8
21	R:R:I68	R:R:T64	67.159	3.04	No	Yes	1	8	8
22	R:R:D126	R:R:Y137	10.1627	5.75	Yes	Yes	1	9	7
23	R:R:R127	R:R:T64	11.2407	9.06	Yes	Yes	1	9	8
24	R:R:R127	R:R:Y137	12.0854	3.09	Yes	Yes	1	9	7
25	R:R:L254	R:R:T64	41.988	5.9	No	Yes	1	8	8
26	R:R:F67	R:R:I123	42.4388	5.02	Yes	No	0	8	9
27	R:R:I123	R:R:L254	43.465	5.71	No	No	0	9	8
28	R:R:C149	R:R:F67	35.4478	5.59	No	Yes	4	6	8
29	R:R:K113	R:R:N296	46.3205	5.6	No	No	0	6	9
30	R:R:F261	R:R:N296	45.1855	15.71	Yes	No	0	9	9
31	R:R:F261	R:R:L120	29.5243	4.87	Yes	No	0	9	8
32	R:R:L120	R:R:M71	12.075	4.24	No	No	0	8	9
33	R:R:P85	R:R:V84	15.5006	3.53	No	No	0	3	8
34	R:R:L87	R:R:V84	12.7747	2.98	No	No	0	5	8
35	R:R:H91	R:R:L87	11.3961	2.57	No	No	0	4	5
36	R:R:H174	R:R:S110	50.6426	4.18	Yes	No	0	4	4
37	R:R:F161	R:R:S110	50.2695	9.25	Yes	No	0	6	4
38	R:R:F161	R:R:V111	46.051	3.93	Yes	No	0	6	5
39	R:R:F107	R:R:V111	44.0661	3.93	Yes	No	0	6	5
40	R:R:F107	R:R:S164	39.9824	5.28	Yes	No	0	6	5
41	R:R:P171	R:R:S164	38.9355	7.13	No	No	0	3	5
42	R:R:P171	R:R:W185	12.1942	4.05	No	No	5	3	7
43	R:R:Q103	R:R:W185	12.0284	16.43	Yes	No	0	5	7
44	R:R:C149	R:R:I153	34.5305	3.27	No	No	0	6	6
45	R:R:I153	R:R:W118	30.2342	7.05	No	Yes	0	6	4
46	R:R:L199	R:R:W118	10.4167	4.56	Yes	Yes	3	7	4
47	R:R:F161	R:R:Y200	15.3607	9.28	Yes	Yes	2	6	5
48	R:R:M117	R:R:Y200	15.7701	4.79	No	Yes	2	7	5
49	R:R:W265	R:R:Y200	11.3495	8.68	Yes	Yes	2	8	5
50	R:R:W118	R:R:Y156	10.4011	4.82	Yes	Yes	3	4	4
51	R:R:L120	R:R:T258	18.3302	10.32	No	No	0	8	7
52	R:R:W265	R:R:Y262	11.5983	4.82	Yes	No	0	8	6
53	R:R:S124	R:R:Y211	19.2631	8.9	No	Yes	0	8	9
54	R:R:T258	R:R:Y211	16.2935	11.24	No	Yes	6	7	9
55	R:R:S124	R:R:T210	17.8431	6.4	No	No	0	8	6
56	R:R:T210	R:R:Y128	16.4127	3.75	No	Yes	0	6	8
57	R:R:N213	R:R:Y128	12.018	4.65	Yes	Yes	7	5	8
58	R:R:I129	R:R:Y137	14.8269	3.63	No	Yes	0	5	7
59	R:R:I129	R:R:L140	12.3808	2.85	No	No	0	5	4
60	R:R:L159	R:R:V160	13.2618	2.98	No	No	0	3	5
61	R:R:L155	R:R:L159	10.6291	4.15	No	No	0	3	3
62	R:R:F161	R:R:I195	11.9092	10.05	Yes	No	2	6	6
63	R:R:F191	R:R:I195	19.9471	6.28	Yes	No	2	5	6
64	R:R:K170	R:R:P171	25.6789	3.35	No	No	5	4	3
65	R:R:K170	R:R:T187	25.596	4.5	No	No	0	4	5
66	R:R:T187	R:R:Y173	21.9216	4.99	No	No	0	5	1
67	R:R:E275	R:R:Y173	18.351	8.98	Yes	No	0	2	1
68	R:R:F261	R:R:M117	22.2585	3.73	Yes	No	0	9	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8HJ0_nogp

PDB Summary
PDB	8HJ0_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.09
Number of Linked Nodes	263
Number of Links	281
Number of Hubs	30
Number of Links mediated by Hubs	112
Number of Communities	8
Number of Nodes involved in Communities	41
Number of Links involved in Communities	52

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	36739
Length Of Smallest Path	3
Average Path Length	16.0937
Length of Longest Path	40
Minimum Path Strength	1.325
Average Path Strength	5.66626
Maximum Path Strength	17.5
Minimum Path Correlation	0.7
Average Path Correlation	0.952477
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	58.5629
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	31.7081
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • cellular response to nitrogen compound • response to peptide hormone • insulin receptor signaling pathway • cell surface receptor protein tyrosine kinase signaling pathway • cellular response to endogenous stimulus • response to hormone • enzyme-linked receptor protein signaling pathway • cellular response to hormone stimulus • cell surface receptor signaling pathway • response to endogenous stimulus • response to oxygen-containing compound • cellular response to peptide hormone stimulus • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • response to insulin • cellular response to insulin stimulus • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • developmental process • regulation of multicellular organism growth • multicellular organismal process • regulation of growth • regulation of developmental growth • regulation of developmental process • developmental growth • growth • positive regulation of biological process • positive regulation of multicellular organism growth • positive regulation of developmental process • multicellular organism growth • positive regulation of growth • positive regulation of multicellular organismal process • regulation of multicellular organismal process • positive regulation of developmental growth • negative regulation of signaling • negative regulation of biological process • regulation of signal transduction • regulation of cellular response to insulin stimulus • negative regulation of cell communication • negative regulation of cellular process • regulation of signaling • negative regulation of response to stimulus • regulation of insulin receptor signaling pathway • negative regulation of signal transduction • negative regulation of cellular response to insulin stimulus • regulation of response to stimulus • negative regulation of insulin receptor signaling pathway • regulation of cell communication • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • metabolic process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99679
Sequence	>8HJ0_nogp_Chain_R V N F C L L E V L I I V F L T V L I I S G N I I V I F V F H C A P L L N H H T T S Y F I Q T M A Y A D L F V G V S C V V P S L S L L H H P L P V E E S L T C Q I F G F V V S V L K S V S M W S L A C I S I D R Y I A I T K P L T Y N T L V T P W R L R L C I F L I W L Y S T L V F L P S F F H W G K P G Y H G D V F Q W C A E S W H T D S Y F T L F I V M M L Y A P A A L I V C F T Y F N I F R I C Q Q H T K D I S E R Q A R F S S M V L F R I T S V F Y I L W L P Y I I Y F L L E S S T G H S N R F A S F L T T W L A I S N S F C N P V I Y A L S D S T F Q R G L K R L S G A M C T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HMV	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	Gs/β1/γ2	2.91	2023-03-01	doi.org/10.1002/mco2.205
	8HMV (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		2.91	2023-03-01	doi.org/10.1002/mco2.205
	8HIX	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	Gs/β1/γ2	3.12	2023-03-15	doi.org/10.1038/s41467-023-35882-w
	8HIX (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		3.12	2023-03-15	doi.org/10.1038/s41467-023-35882-w
	8HJ0	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	chim(Gs-CtG15)/β1/γ2	3.12	2023-03-15	doi.org/10.1038/s41467-023-35882-w
	8HJ0 (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		3.12	2023-03-15	doi.org/10.1038/s41467-023-35882-w
	8HJ2	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	chim(Gs-CtG15)/β1/γ2	3.8	2023-03-15	doi.org/10.1038/s41467-023-35882-w
	8HJ2 (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		3.8	2023-03-15	doi.org/10.1038/s41467-023-35882-w
	8HJ1	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	Gs/β1/γ2	3.27	2023-12-27	doi.org/10.1038/s41467-023-35882-w
	8HJ1 (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		3.27	2023-12-27	doi.org/10.1038/s41467-023-35882-w

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8HJ0_nogp.zip

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