psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F27	R:R:H92	19.23	No	No	0	1	4
2	R:R:E31	R:R:L30	3.98	Yes	No	0	4	5
3	R:R:E31	R:R:R283	3.49	Yes	No	0	4	3
4	R:R:E31	R:R:F287	7	Yes	No	0	4	5
5	R:R:L89	R:R:V32	5.96	No	No	0	4	4
6	R:R:L90	R:R:V32	5.96	No	No	0	5	4
7	R:R:I35	R:R:W291	10.57	No	Yes	0	6	4
8	R:R:F37	R:R:L41	9.74	No	No	0	4	4
9	R:R:L38	R:R:W291	4.56	No	Yes	0	7	4
10	R:R:F298	R:R:L38	3.65	Yes	No	0	6	7
11	R:R:F298	R:R:L41	4.87	Yes	No	0	6	4
12	R:R:I42	R:R:N46	4.25	Yes	No	0	8	9
13	R:R:G79	R:R:I42	3.53	No	Yes	0	7	8
14	R:R:I42	R:R:S297	9.29	Yes	No	0	8	9
15	R:R:F298	R:R:I42	5.02	Yes	Yes	0	6	8
16	R:R:G45	R:R:S44	3.71	No	No	0	8	4
17	R:R:G45	R:R:I48	3.53	No	No	0	8	7
18	R:R:C301	R:R:G45	3.92	No	No	0	9	8
19	R:R:D75	R:R:N46	6.73	No	No	0	9	9
20	R:R:L76	R:R:N46	6.87	Yes	No	0	6	9
21	R:R:F51	R:R:I47	3.77	No	No	0	4	5
22	R:R:C301	R:R:V49	3.42	No	No	0	9	9
23	R:R:F311	R:R:V49	5.24	Yes	No	0	9	9
24	R:R:I50	R:R:Y73	6.04	No	No	0	7	6
25	R:R:F53	R:R:V52	3.93	Yes	No	3	7	8
26	R:R:F311	R:R:V52	13.11	Yes	No	3	9	8
27	R:R:F53	R:R:I68	8.79	Yes	No	0	7	8
28	R:R:F53	R:R:Q69	9.37	Yes	No	0	7	6
29	R:R:F311	R:R:F53	5.36	Yes	Yes	3	9	7
30	R:R:C55	R:R:L318	4.76	No	No	0	5	6
31	R:R:A56	R:R:L59	6.3	No	No	0	5	9
32	R:R:N60	R:R:Y66	5.81	No	Yes	0	5	4
33	R:R:N60	R:R:Q69	5.28	No	No	0	5	6
34	R:R:D126	R:R:T63	10.12	Yes	No	4	9	5
35	R:R:T63	R:R:Y137	4.99	No	Yes	4	5	7
36	R:R:I123	R:R:T64	6.08	No	No	0	9	8
37	R:R:D126	R:R:T64	4.34	Yes	No	0	9	8
38	R:R:S65	R:R:Y66	3.82	No	Yes	0	9	4
39	R:R:L146	R:R:Y66	10.55	No	Yes	0	7	4
40	R:R:C122	R:R:F67	8.38	No	Yes	0	7	8
41	R:R:F67	R:R:I123	3.77	Yes	No	0	8	9
42	R:R:D126	R:R:F67	3.58	Yes	Yes	0	9	8
43	R:R:F67	R:R:I150	3.77	Yes	No	0	8	8
44	R:R:I68	R:R:Y304	6.04	No	Yes	0	8	9
45	R:R:I150	R:R:T70	9.12	No	No	0	8	9
46	R:R:M71	R:R:S119	9.2	No	No	0	9	8
47	R:R:L120	R:R:M71	4.24	No	No	0	8	9
48	R:R:M71	R:R:N300	4.21	No	No	0	9	9
49	R:R:D75	R:R:S116	5.89	No	No	0	9	9
50	R:R:D75	R:R:S297	5.89	No	No	0	9	9
51	R:R:V109	R:R:V78	4.81	No	Yes	0	6	8
52	R:R:L112	R:R:V78	5.96	No	Yes	0	6	8
53	R:R:K113	R:R:V78	4.55	No	Yes	0	6	8
54	R:R:L87	R:R:V83	4.47	No	No	0	5	7
55	R:R:P85	R:R:V84	3.53	No	No	0	3	8
56	R:R:F105	R:R:P85	11.56	Yes	No	0	5	3
57	R:R:F178	R:R:S88	5.28	Yes	No	0	4	5
58	R:R:E98	R:R:L94	7.95	No	No	0	7	4
59	R:R:L100	R:R:S99	4.5	No	No	0	1	3
60	R:R:L100	R:R:Q103	3.99	No	No	0	1	5
61	R:R:C102	R:R:W180	5.22	No	No	0	9	3
62	R:R:C102	R:R:C181	5.46	No	No	0	9	9
63	R:R:Q103	R:R:W185	16.43	No	No	0	5	7
64	R:R:F105	R:R:V109	7.87	Yes	No	0	5	6
65	R:R:F107	R:R:V111	7.87	No	No	0	6	5
66	R:R:F161	R:R:S110	9.25	Yes	No	0	6	4
67	R:R:P171	R:R:S110	3.56	No	No	5	3	4
68	R:R:H174	R:R:S110	9.76	Yes	No	5	4	4
69	R:R:F161	R:R:V111	6.55	Yes	No	0	6	5
70	R:R:I294	R:R:K113	5.82	No	No	0	7	6
71	R:R:S114	R:R:S157	6.52	No	No	0	6	8
72	R:R:F161	R:R:S114	6.61	Yes	No	0	6	6
73	R:R:L199	R:R:S114	6.01	No	No	0	7	6
74	R:R:V115	R:R:W154	12.26	No	No	0	7	9
75	R:R:S157	R:R:V115	4.85	No	No	0	8	7
76	R:R:L199	R:R:M117	4.24	No	Yes	1	7	7
77	R:R:M117	R:R:Y200	7.18	Yes	Yes	1	7	5
78	R:R:A203	R:R:M117	4.83	No	Yes	0	6	7
79	R:R:F261	R:R:M117	3.73	Yes	Yes	0	9	7
80	R:R:M117	R:R:W265	4.65	Yes	Yes	1	7	8
81	R:R:L120	R:R:T258	4.42	No	No	0	8	7
82	R:R:F261	R:R:L120	6.09	Yes	No	0	9	8
83	R:R:S124	R:R:V207	6.46	No	No	0	8	5
84	R:R:S124	R:R:T210	6.4	No	No	0	8	6
85	R:R:L254	R:R:S124	6.01	No	No	0	8	8
86	R:R:I125	R:R:I206	4.42	No	No	0	6	8
87	R:R:D126	R:R:Y137	5.75	Yes	Yes	4	9	7
88	R:R:R127	R:R:V253	3.92	No	No	0	9	8
89	R:R:L254	R:R:R127	8.5	No	No	0	8	9
90	R:R:T132	R:R:Y128	16.23	No	Yes	0	6	8
91	R:R:F209	R:R:Y128	6.19	No	Yes	6	4	8
92	R:R:T210	R:R:Y128	3.75	No	Yes	0	6	8
93	R:R:N213	R:R:Y128	5.81	No	Yes	6	5	8
94	R:R:A130	R:R:Y137	5.34	No	Yes	0	8	7
95	R:R:I131	R:R:I217	4.42	No	No	0	9	6
96	R:R:N138	R:R:Y137	4.65	No	Yes	0	4	7
97	R:R:V141	R:R:Y137	6.31	No	Yes	0	6	7
98	R:R:P143	R:R:T142	3.5	No	No	0	3	8
99	R:R:R145	R:R:T142	9.06	No	No	0	5	8
100	R:R:F151	R:R:L155	4.87	No	No	0	4	3
101	R:R:V160	R:R:Y156	8.83	No	No	0	5	4
102	R:R:M198	R:R:Y156	8.38	No	No	0	6	4
103	R:R:F161	R:R:V160	5.24	Yes	No	0	6	5
104	R:R:F194	R:R:V160	3.93	No	No	0	6	5
105	R:R:F191	R:R:P163	10.11	Yes	No	0	5	5
106	R:R:P171	R:R:S164	7.13	No	No	0	3	5
107	R:R:G172	R:R:K170	3.49	No	Yes	0	1	4
108	R:R:K170	R:R:Y173	7.17	Yes	Yes	2	4	1
109	R:R:D176	R:R:K170	12.44	No	Yes	2	4	4
110	R:R:K170	R:R:W185	12.76	Yes	No	0	4	7
111	R:R:K170	R:R:T187	4.5	Yes	No	2	4	5
112	R:R:H174	R:R:P171	6.1	Yes	No	5	4	3
113	R:R:G172	R:R:H174	6.35	No	Yes	0	1	4
114	R:R:F272	R:R:G172	4.52	Yes	No	0	5	1
115	R:R:D176	R:R:Y173	5.75	No	Yes	2	4	1
116	R:R:T187	R:R:Y173	6.24	No	Yes	2	5	1
117	R:R:F272	R:R:Y173	7.22	Yes	Yes	0	5	1
118	R:R:E275	R:R:Y173	15.71	No	Yes	0	2	1
119	R:R:H174	R:R:Y268	4.36	Yes	Yes	0	4	6
120	R:R:C181	R:R:F178	5.59	No	Yes	0	9	4
121	R:R:S184	R:R:W180	19.77	No	No	0	3	3
122	R:R:S276	R:R:T187	6.4	No	No	0	3	5
123	R:R:D188	R:R:Y190	6.9	No	No	0	3	7
124	R:R:F191	R:R:I195	3.77	Yes	Yes	0	5	6
125	R:R:I195	R:R:T192	4.56	Yes	Yes	0	6	4
126	R:R:F272	R:R:T192	7.78	Yes	Yes	0	5	4
127	R:R:S276	R:R:T192	4.8	No	Yes	0	3	4
128	R:R:L193	R:R:M197	5.65	No	No	0	4	4
129	R:R:F194	R:R:I195	5.02	No	Yes	0	6	6
130	R:R:F194	R:R:M198	3.73	No	No	0	6	6
131	R:R:I195	R:R:Y200	9.67	Yes	Yes	0	6	5
132	R:R:V196	R:R:Y200	3.79	No	Yes	0	5	5
133	R:R:L199	R:R:Y200	11.72	No	Yes	1	7	5
134	R:R:W265	R:R:Y200	8.68	Yes	Yes	1	8	5
135	R:R:I269	R:R:Y200	6.04	No	Yes	1	7	5
136	R:R:T258	R:R:V207	4.76	No	No	0	7	5
137	R:R:V207	R:R:Y262	6.31	No	No	0	5	6
138	R:R:F209	R:R:N213	9.67	No	No	6	4	5
139	R:R:F215	R:R:Y211	12.38	No	No	0	6	9
140	R:R:M252	R:R:Y211	7.18	No	No	7	7	9
141	R:R:F255	R:R:Y211	29.91	No	No	7	5	9
142	R:R:F212	R:R:N213	3.62	No	No	0	3	5
143	R:R:F212	R:R:R216	5.34	No	No	0	3	3
144	R:R:F215	R:R:Q219	14.05	No	No	0	6	5
145	R:R:D224	R:R:K223	6.91	No	No	0	4	4
146	R:R:F232	R:R:R231	6.41	No	No	0	4	6
147	R:R:A251	R:R:R256	4.15	No	No	0	7	6
148	R:R:L254	R:R:M252	7.07	No	No	0	8	7
149	R:R:F255	R:R:M252	9.95	No	No	7	5	7
150	R:R:N308	R:R:V253	5.91	Yes	No	0	8	8
151	R:R:F255	R:R:R256	9.62	No	No	0	5	6
152	R:R:I257	R:R:I303	7.36	No	No	0	8	8
153	R:R:I257	R:R:Y304	6.04	No	Yes	0	8	9
154	R:R:C299	R:R:V260	3.42	No	No	0	5	6
155	R:R:F261	R:R:Y262	7.22	Yes	No	0	9	6
156	R:R:F261	R:R:N296	19.33	Yes	No	0	9	9
157	R:R:F261	R:R:N300	4.83	Yes	No	0	9	9
158	R:R:L264	R:R:L292	5.54	No	No	0	8	6
159	R:R:L264	R:R:N296	8.24	No	No	0	8	9
160	R:R:W265	R:R:Y268	5.79	Yes	Yes	0	8	6
161	R:R:I269	R:R:W265	4.7	No	Yes	1	7	8
162	R:R:P267	R:R:T289	3.5	Yes	No	0	9	5
163	R:R:F272	R:R:Y268	12.38	Yes	Yes	0	5	6
164	R:R:T290	R:R:Y268	3.75	No	Yes	0	5	6
165	R:R:I270	R:R:Y271	10.88	No	No	0	7	5
166	R:R:H280	R:R:L274	3.86	No	No	0	1	4
167	R:R:E275	R:R:S286	10.06	No	No	0	2	4
168	R:R:H280	R:R:N282	5.1	No	No	0	1	4
169	R:R:F284	R:R:R283	4.28	No	No	0	1	3
170	R:R:F287	R:R:W291	7.02	No	Yes	0	5	4
171	R:R:T290	R:R:W291	4.85	No	Yes	0	5	4
172	R:R:I294	R:R:W291	11.74	No	Yes	0	7	4
173	R:R:F298	R:R:S295	9.25	Yes	No	0	6	6
174	R:R:C299	R:R:V302	3.42	No	No	0	5	6
175	R:R:N308	R:R:Y304	6.98	Yes	Yes	0	8	9
176	R:R:F311	R:R:Y304	10.32	Yes	Yes	0	9	9
177	R:R:N308	R:R:V310	5.91	Yes	No	0	8	6
178	R:R:F311	R:R:L315	3.65	Yes	No	0	9	6
179	R:R:K316	R:R:Q312	9.49	No	No	0	5	9
180	R:R:R313	R:R:R317	4.26	No	No	8	4	4
181	R:R:A74	R:R:V115	3.39	No	No	0	8	7
182	R:R:C82	R:R:T39	3.38	No	Yes	0	7	6
183	R:R:L87	R:R:P93	3.28	No	No	0	5	4
184	R:R:L292	R:R:P267	3.28	No	Yes	0	6	9
185	R:R:C122	R:R:I153	3.27	No	No	0	7	6
186	R:R:S233	R:R:S234	3.26	No	No	0	2	4
187	R:R:A72	R:R:I50	3.25	No	No	0	9	7
188	R:R:A118	R:R:I153	3.25	No	No	0	4	6
189	R:R:S81	R:R:V78	3.23	No	Yes	0	5	8
190	R:R:S81	R:R:V108	3.23	No	No	0	5	4
191	R:R:S99	R:R:V96	3.23	No	No	0	3	3
192	R:R:F165	R:R:F166	3.22	No	No	0	5	3
193	R:R:G106	R:R:H174	3.18	No	Yes	0	4	4
194	R:R:C28	R:R:L89	3.17	No	No	0	4	4
195	R:R:T39	R:R:V36	3.17	Yes	No	0	6	4
196	R:R:T39	R:R:V40	3.17	Yes	No	0	6	5
197	R:R:T39	R:R:V83	3.17	Yes	No	0	6	7
198	R:R:T158	R:R:V111	3.17	No	No	0	3	5
199	R:R:A285	R:R:N282	3.13	No	No	0	4	4
200	R:R:C181	R:R:D176	3.11	No	No	0	9	4
201	R:R:F105	R:R:G175	3.01	Yes	No	0	5	3
202	R:R:F191	R:R:G169	3.01	Yes	No	0	5	5
203	R:R:L76	R:R:V80	2.98	Yes	No	0	6	4
204	R:R:L146	R:R:T63	2.95	No	No	0	7	5
205	R:R:L140	R:R:T136	2.95	No	Yes	0	4	4
206	R:R:L273	R:R:T192	2.95	No	Yes	0	6	4
207	R:R:I131	R:R:I214	2.94	No	No	0	9	9
208	R:R:I50	R:R:L76	2.85	No	Yes	0	7	6
209	R:R:H62	R:R:S65	2.79	No	No	0	7	9
210	R:R:C82	R:R:F105	2.79	No	Yes	0	7	5
211	R:R:P267	R:R:Y271	2.78	Yes	No	0	9	5
212	R:R:L155	R:R:L159	2.77	No	No	0	3	3
213	R:R:L29	R:R:N26	2.75	No	No	0	4	1
214	R:R:I217	R:R:Q220	2.74	No	No	0	6	4
215	R:R:A293	R:R:Y268	2.67	No	Yes	0	7	6
216	R:R:H221	R:R:I217	2.65	No	No	0	7	6
217	R:R:R256	R:R:S259	2.64	No	No	0	6	4
218	R:R:R313	R:R:S309	2.64	No	No	0	4	4
219	R:R:F178	R:R:V177	2.62	Yes	No	0	4	2
220	R:R:F77	R:R:L112	2.44	No	No	0	7	6
221	R:R:F166	R:R:L162	2.44	No	No	0	3	4
222	R:R:T142	R:R:W144	2.43	No	No	0	8	4
223	R:R:D188	R:R:F191	2.39	No	Yes	0	3	5
224	R:R:L274	R:R:Y271	2.34	No	No	0	4	5
225	R:R:E98	R:R:F178	2.33	No	Yes	0	7	4
226	R:R:L148	R:R:W144	2.28	No	No	0	2	4
227	R:R:F232	R:R:R228	2.14	No	No	0	4	3
228	R:R:A56	R:R:P57	1.87	No	No	0	5	6
229	R:R:A201	R:R:P202	1.87	No	No	0	4	9
230	R:R:G320	R:R:S319	1.86	No	No	0	3	4
231	R:R:A121	R:R:A203	1.79	No	No	0	7	6
232	R:R:G79	R:R:I43	1.76	No	No	0	7	6
233	R:R:C301	R:R:S305	1.72	No	No	0	9	7
234	R:R:C218	R:R:T222	1.69	No	No	0	8	5
235	R:R:K133	R:R:P134	1.67	No	No	0	5	8
236	R:R:L94	R:R:P95	1.64	No	No	0	4	7
237	R:R:L162	R:R:P163	1.64	No	No	0	4	5
238	R:R:L266	R:R:P267	1.64	No	Yes	0	6	9
239	R:R:S189	R:R:S276	1.63	No	No	0	4	3
240	R:R:S86	R:R:V36	1.62	No	No	0	7	4
241	R:R:S86	R:R:V83	1.62	No	No	0	7	7
242	R:R:A121	R:R:I206	1.62	No	No	0	7	8
243	R:R:C323	R:R:M322	1.62	No	No	0	5	3
244	R:R:S226	R:R:T222	1.6	No	No	0	3	5
245	R:R:T136	R:R:T139	1.57	Yes	No	0	4	4
246	R:R:I263	R:R:S259	1.55	No	No	0	5	4
247	R:R:K316	R:R:S319	1.53	No	No	0	5	4
248	R:R:C28	R:R:E31	1.52	No	Yes	0	4	4
249	R:R:K133	R:R:T132	1.5	No	No	0	5	6
250	R:R:K133	R:R:T136	1.5	No	Yes	0	5	4
251	R:R:L273	R:R:S277	1.5	No	No	0	6	4
252	R:R:L306	R:R:S305	1.5	No	No	0	5	7
253	R:R:G314	R:R:R313	1.5	No	No	8	7	4
254	R:R:G314	R:R:R317	1.5	No	No	8	7	4
255	R:R:L59	R:R:V52	1.49	No	No	0	9	8
256	R:R:L264	R:R:V260	1.49	No	No	0	8	6
257	R:R:N308	R:R:S307	1.49	Yes	No	0	8	7
258	R:R:L135	R:R:T136	1.47	No	Yes	0	7	4
259	R:R:E183	R:R:S184	1.44	No	No	0	5	3
260	R:R:I34	R:R:L38	1.43	No	No	0	5	7
261	R:R:I47	R:R:L76	1.43	No	Yes	0	5	6
262	R:R:I129	R:R:L140	1.43	No	No	0	5	4
263	R:R:G169	R:R:W168	1.41	No	No	0	5	5
264	R:R:H280	R:R:T278	1.37	No	No	0	1	4
265	R:R:E227	R:R:K223	1.35	No	No	0	3	4
266	R:R:E97	R:R:L94	1.33	No	No	0	5	4
267	R:R:A204	R:R:Y262	1.33	No	No	0	3	6
268	R:R:F178	R:R:T101	1.3	Yes	No	0	4	5
269	R:R:H91	R:R:L87	1.29	No	No	0	4	5
270	R:R:E183	R:R:Q179	1.27	No	No	0	5	4
271	R:R:F51	R:R:L318	1.22	No	No	0	4	6
272	R:R:F287	R:R:L288	1.22	No	No	0	5	4
273	R:R:I214	R:R:Y128	1.21	No	Yes	0	9	8
274	R:R:L140	R:R:R145	1.21	No	No	0	4	5
275	R:R:L146	R:R:R147	1.21	No	No	0	7	1
276	R:R:H61	R:R:Y66	1.09	No	Yes	0	8	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:E31	3.9975	4	0	4
2	R:R:T39	3.2225	4	0	6
3	R:R:I42	5.5225	4	0	8
4	R:R:F53	6.8625	4	3	7
5	R:R:Y66	5.3175	4	0	4
6	R:R:F67	4.875	4	0	8
7	R:R:L76	3.5325	4	0	6
8	R:R:V78	4.6375	4	0	8
9	R:R:F105	6.3075	4	0	5
10	R:R:M117	4.926	5	1	7
11	R:R:D126	5.9475	4	4	9
12	R:R:Y128	6.638	5	6	8
13	R:R:T136	1.8725	4	0	4
14	R:R:Y137	5.408	5	4	7
15	R:R:F161	6.9125	4	0	6
16	R:R:K170	8.072	5	2	4
17	R:R:Y173	8.418	5	2	1
18	R:R:H174	5.95	5	5	4
19	R:R:F178	3.424	5	0	4
20	R:R:F191	4.82	4	0	5
21	R:R:T192	5.0225	4	0	4
22	R:R:I195	5.755	4	0	6
23	R:R:Y200	7.84667	6	1	5
24	R:R:F261	8.24	5	0	9
25	R:R:W265	5.955	4	1	8
26	R:R:P267	2.8	4	0	9
27	R:R:Y268	5.79	5	0	6
28	R:R:F272	7.975	4	0	5
29	R:R:W291	7.748	5	0	4
30	R:R:F298	5.6975	4	0	6
31	R:R:Y304	7.345	4	0	9
32	R:R:N308	5.0725	4	0	8
33	R:R:F311	7.536	5	3	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E31	R:R:F287	11.7602	7	Yes	No	0	4	5
2	R:R:F287	R:R:W291	14.6005	7.02	No	Yes	0	5	4
3	R:R:L38	R:R:W291	33.3502	4.56	No	Yes	0	7	4
4	R:R:F298	R:R:L38	30.7929	3.65	Yes	No	0	6	7
5	R:R:F298	R:R:I42	25.5572	5.02	Yes	Yes	0	6	8
6	R:R:I42	R:R:N46	17.2689	4.25	Yes	No	0	8	9
7	R:R:T290	R:R:W291	70.5918	4.85	No	Yes	0	5	4
8	R:R:T290	R:R:Y268	71.5116	3.75	No	Yes	0	5	6
9	R:R:W265	R:R:Y268	83.7317	5.79	Yes	Yes	0	8	6
10	R:R:M117	R:R:W265	76.9293	4.65	Yes	Yes	1	7	8
11	R:R:F261	R:R:M117	100	3.73	Yes	Yes	0	9	7
12	R:R:F261	R:R:Y262	91.6814	7.22	Yes	No	0	9	6
13	R:R:V207	R:R:Y262	91.0143	6.31	No	No	0	5	6
14	R:R:S124	R:R:V207	92.7983	6.46	No	No	0	8	5
15	R:R:L254	R:R:S124	80.8561	6.01	No	No	0	8	8
16	R:R:L254	R:R:R127	74.2861	8.5	No	No	0	8	9
17	R:R:R127	R:R:V253	73.5736	3.92	No	No	0	9	8
18	R:R:N308	R:R:V253	72.8509	5.91	Yes	No	0	8	8
19	R:R:N308	R:R:Y304	70.6221	6.98	Yes	Yes	0	8	9
20	R:R:F311	R:R:Y304	40.8046	10.32	Yes	Yes	0	9	9
21	R:R:L76	R:R:N46	13.1399	6.87	Yes	No	0	6	9
22	R:R:I68	R:R:Y304	27.5838	6.04	No	Yes	0	8	9
23	R:R:F53	R:R:I68	26.6235	8.79	Yes	No	0	7	8
24	R:R:F311	R:R:F53	27.5737	5.36	Yes	Yes	3	9	7
25	R:R:F53	R:R:Q69	52.4183	9.37	Yes	No	0	7	6
26	R:R:N60	R:R:Q69	50.2502	5.28	No	No	0	5	6
27	R:R:N60	R:R:Y66	48.072	5.81	No	Yes	0	5	4
28	R:R:D126	R:R:T63	23.2425	10.12	Yes	No	4	9	5
29	R:R:L146	R:R:T63	34.7905	2.95	No	No	0	7	5
30	R:R:L146	R:R:Y66	39.2581	10.55	No	Yes	0	7	4
31	R:R:D126	R:R:F67	16.4755	3.58	Yes	Yes	0	9	8
32	R:R:I294	R:R:W291	30.7475	11.74	No	Yes	0	7	4
33	R:R:I294	R:R:K113	29.4537	5.82	No	No	0	7	6
34	R:R:K113	R:R:V78	28.1397	4.55	No	Yes	0	6	8
35	R:R:V109	R:R:V78	21.499	4.81	No	Yes	0	6	8
36	R:R:F105	R:R:V109	20.1243	7.87	Yes	No	0	5	6
37	R:R:C82	R:R:F105	14.5904	2.79	No	Yes	0	7	5
38	R:R:C82	R:R:T39	13.1854	3.38	No	Yes	0	7	6
39	R:R:F272	R:R:Y268	40.0566	12.38	Yes	Yes	0	5	6
40	R:R:F272	R:R:Y173	28.9786	7.22	Yes	Yes	0	5	1
41	R:R:D176	R:R:Y173	17.5823	5.75	No	Yes	2	4	1
42	R:R:C181	R:R:D176	18.3201	3.11	No	No	0	9	4
43	R:R:C181	R:R:F178	10.7091	5.59	No	Yes	0	9	4
44	R:R:H174	R:R:Y268	16.4856	4.36	Yes	Yes	0	4	6
45	R:R:G172	R:R:K170	15.1413	3.49	No	Yes	0	1	4
46	R:R:K170	R:R:W185	17.8855	12.76	Yes	No	0	4	7
47	R:R:Q103	R:R:W185	14.3276	16.43	No	No	0	5	7
48	R:R:L100	R:R:Q103	10.7596	3.99	No	No	0	1	5
49	R:R:L199	R:R:M117	11.1942	4.24	No	Yes	1	7	7
50	R:R:L199	R:R:S114	12.4375	6.01	No	No	0	7	6
51	R:R:S124	R:R:T210	30.985	6.4	No	No	0	8	6
52	R:R:T210	R:R:Y128	29.8074	3.75	No	Yes	0	6	8
53	R:R:T132	R:R:Y128	17.5014	16.23	No	Yes	0	6	8
54	R:R:K133	R:R:T132	16.2127	1.5	No	No	0	5	6
55	R:R:K133	R:R:T136	13.6049	1.5	No	Yes	0	5	4
56	R:R:I195	R:R:Y200	20.0283	9.67	Yes	Yes	0	6	5
57	R:R:I195	R:R:T192	12.3768	4.56	Yes	Yes	0	6	4
58	R:R:F191	R:R:I195	15.3687	3.77	Yes	Yes	0	5	6
59	R:R:L254	R:R:M252	12.3212	7.07	No	No	0	8	7
60	R:R:L264	R:R:N296	20.2355	8.24	No	No	0	8	9
61	R:R:F261	R:R:N296	21.504	19.33	Yes	No	0	9	9
62	R:R:L264	R:R:L292	15.0604	5.54	No	No	0	8	6
63	R:R:L292	R:R:P267	13.7413	3.28	No	Yes	0	6	9
64	R:R:M117	R:R:Y200	16.6119	7.18	Yes	Yes	1	7	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8HJ1_nogp

PDB Summary
PDB	8HJ1_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.42
Number of Linked Nodes	265
Number of Links	276
Number of Hubs	33
Number of Links mediated by Hubs	126
Number of Communities	8
Number of Nodes involved in Communities	27
Number of Links involved in Communities	30

Path Summary
Number Of Nodes in MetaPath	65
Number Of Links MetaPath	64
Number of Shortest Paths	38421
Length Of Smallest Path	3
Average Path Length	15.458
Length of Longest Path	36
Minimum Path Strength	1.32
Average Path Strength	6.07738
Maximum Path Strength	21.145
Minimum Path Correlation	0.7
Average Path Correlation	0.951893
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	59.9874
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.7533
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • response to peptide hormone • insulin receptor signaling pathway • cell surface receptor protein tyrosine kinase signaling pathway • enzyme-linked receptor protein signaling pathway • cell surface receptor signaling pathway • cellular response to peptide hormone stimulus • response to insulin • cellular response to insulin stimulus • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • regulation of developmental process • developmental growth • growth • positive regulation of biological process • positive regulation of multicellular organism growth • positive regulation of developmental process • multicellular organism growth • positive regulation of growth • positive regulation of multicellular organismal process • regulation of multicellular organismal process • positive regulation of developmental growth • negative regulation of signaling • negative regulation of biological process • regulation of signal transduction • regulation of cellular response to insulin stimulus • negative regulation of cell communication • negative regulation of cellular process • regulation of signaling • negative regulation of response to stimulus • regulation of insulin receptor signaling pathway • negative regulation of signal transduction • negative regulation of cellular response to insulin stimulus • regulation of response to stimulus • negative regulation of insulin receptor signaling pathway • regulation of cell communication
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q99679
Sequence	>8HJ1_nogp_Chain_R N F C L L E V L I I V F L T V L I I S G N I I V I F V F H C A P L L N H H T T S Y F I Q T M A Y A D L F V G V S C V V P S L S L L H H P L P V E E S L T C Q I F G F V V S V L K S V S M A S L A C I S I D R Y I A I T K P L T Y N T L V T P W R L R L C I F L I W L Y S T L V F L P S F F H W G K P G Y H G D V F Q W C A E S W H T D S Y F T L F I V M M L Y A P A A L I V C F T Y F N I F R I C Q Q H T K D I S E R Q A R F S S A M V L F R I T S V F Y I L W L P Y I I Y F L L E S S T G H S N R F A S F L T T W L A I S N S F C N C V I Y S L S N S V F Q R G L K R L S G A M C T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HJ1	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	Gs/β1/γ2	3.27	2023-12-27	10.1038/s41467-023-35882-w
	8HJ1 (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		3.27	2023-12-27	10.1038/s41467-023-35882-w
	8HJ2	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	chim(Gs-CtG15)/β1/γ2	3.8	2023-03-15	10.1038/s41467-023-35882-w
	8HJ2 (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		3.8	2023-03-15	10.1038/s41467-023-35882-w
	8HJ0	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	chim(Gs-CtG15)/β1/γ2	3.12	2023-03-15	10.1038/s41467-023-35882-w
	8HJ0 (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		3.12	2023-03-15	10.1038/s41467-023-35882-w
	8HIX	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	Gs/β1/γ2	3.12	2023-03-15	10.1038/s41467-023-35882-w
	8HIX (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		3.12	2023-03-15	10.1038/s41467-023-35882-w
	8HMV	A	Orphan	Orphan	GPR21	Homo sapiens	-	-	Gs/β1/γ2	2.91	2023-03-01	10.1002/mco2.205
	8HMV (No Gprot)	A	Orphan	Orphan	GPR21	Homo sapiens	-	-		2.91	2023-03-01	10.1002/mco2.205

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